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  • Exogenous salicylic acid ameliorates heat stress-induced damages and improves growth and photosynthetic efficiency in alfalfa (Medicago sativa L.)
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-16
    Misganaw Wassie; Weihong Zhang; Qiang Zhang; Kang Ji; Liwen Cao; Liang Chen

    Heat stress is found to be a detrimental factor for growth and development of alfalfa (Medicago sativa L.) which is tremendously invaluable forage due to its high feed value and yield potential. Salicylic acid (SA) has been reported to play a pivotal role in the regulation of plants biotic and abiotic stress response. However, the role of exogenous SA in protecting alfalfa from heat-induced damage has rarely been studied. In this study, four-week-old alfalfa seedlings were treated with 0.25 mM or 0.5 mM SA five days prior to high stress treatment (three day), and various growth and physiological traits were measured. The results showed that exogenous SA pretreatment could improve leaf morphology, plant height, biomass, chlorophyll content, and photosynthetic efficiency of alfalfa under heat stress. Meanwhile, SA could alleviate heat-induced membrane damage by reducing electrolyte leakage (EL) and malondialdehyde (MDA) content, and regulate the activities of antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and peroxidase (POD). The results revealed that exogenous SA application enhanced alfalfa heat tolerance by modulating various morphological and physiological characteristics under heat stress, with more prominent effect at lower concentration (0.25 mM). Overall, this study provides fundamental insights into the SA-mediated physiological adaptation of alfalfa plants to heat stress, which could have useful implication in managing other plants which are suffering global warming.

    更新日期:2020-01-16
  • Toxicokinetics and bioaccumulation characteristics of bisphenol analogues in common carp (Cyprinus carpio)
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-15
    Qiang Wang; Meng Chen; Liwen Qiang; Wei Wu; Jing Yang; Lingyan Zhu
    更新日期:2020-01-16
  • In-vitro evaluation of rice straw biochars’ effect on bispyribac-sodium dissipation and microbial activity in soil
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-16
    Neha Sharma; Pervinder Kaur; Deepali Jain; Makhan Singh Bhullar
    更新日期:2020-01-16
  • Highly biodegradable fluoroquinolone derivatives designed using the 3D-QSAR model and biodegradation pathways analysis
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-16
    Yilin Hou; Yuanyuan Zhao; Qing Li; Yu Li

    A three-dimensional quantitative structure–activity relationship (3D-QSAR) model was established based on molecular structures and docking scores (representing the biodegradability); the scores were obtained for 23 fluoroquinolones (FQs) and the oxidoreductase (PDB ID: 1YZP) of Phanerochaete chrysosporium in the aerobic process of municipal wastewater treatment plants. In the Comparative Molecular Field Analysis (CoMFA) model, q2 was 0.516 and r2pred was 0.727, which showed that the model was reliable and robust. The modification information obtained by the contour maps showed that introducing electronegative, bulky or electropositive groups at different active sites could increase the biodegradability of fluoroquinolone derivatives. Using levofloxacin (LEV) as a modified molecule, 35 fluoroquinolone derivatives with higher biodegradability than LEV were designed. After the evaluation of genotoxicity, bioconcentration and photodegradation, Derivative-15, with higher biodegradability (increased by 27.85%), higher genotoxicity, higher photodegradation and lower bioconcentration, was identified as the most environmentally friendly fluoroquinolone derivative. The 2D-QSAR model of FQ biodegradability was established through the quantization parameters, and q+ was identified as the main parameter affecting the biodegradability of FQs through sensitivity analysis. In addition, the docking results of LEV and Derivative-15 with the oxidoreductase in P. chrysosporium showed that the electrostatic field force between Derivative-15 and the amino acid residues promoted the binding of the donor to the receptor protein, thereby increasing the biodegradability of Derivative-15. Additionally, molecular dynamics simulations revealed that the enhancement of the electrostatic field force with Derivative-15 could promote the binding of the ligand to the receptor, which was basically consistent with the conclusion of molecular docking. Finally, the three microbial degradation pathways of LEV and Derivative-15 were also proposed. The total energy barrier value of the pathway with the lowest total energy barrier of biodegradation was reduced by 32.07%, which was basically consistent with the enhancement of biodegradability of Derivative-15.

    更新日期:2020-01-16
  • Differences in distribution of functional microorganism at DNA and cDNA levels in cow manure composting
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-15
    Qingxin Meng; Yue Han; Haifeng Zhu; Wei Yang; Ayodeji Bello; Liting Deng; Xin Jiang; Xiaotong Wu; Siyuan Sheng; Yingying Xu; Xiuhong Xu

    Denitrification and nitrification processes are the two prominent pathways of nitrogen (N) transformation in composting matrix. This study explored the dynamics of denitrifying and nitrifying bacteria at different composting stages of cow manure and corn straw using functional gene sequencing at DNA and cDNA levels. Corresponding agreement among OTUs, NMDS, mental test and network analyses revealed that functional bacteria community compositions and responses to physicochemical factors were different at DNA and cDNA levels. Specifically, some OTUs were detected at the DNA level but were not observed at cDNA level, differences were also found in the distribution patterns of nitrifying and denitrifying bacteria communities at both levels. Furthermore, co-occurrence network analysis indicated that Pseudomonas, Paracoccus and Nitrosomonas were identified as the keystone OTUs at the DNA level, while Paracoccus, Agrobacterium and Nitrosospira were keystone OTUs at the cDNA level. Mantel test revealed that TN, C/N and moisture content significantly influenced both the denitrifying bacteria and ammonia-oxidizing bacteria (AOB) communities at the DNA level. NO3−-N, NH4+-N, TN, C/N, and moisture content only registered significant correlation with the nosZ-type denitrifiers and ammonia-oxidizing bacteria (AOB) communities at the cDNA level. Structural equation model (SEM) showed that TN, NH4+-N, and pH were direct and significantly influenced the gene abundance of denitrifying bacteria. Howbeit, TN, NH4+-N, and NO3−-N had significant direct effects on amoA gene abundance.

    更新日期:2020-01-15
  • Accumulation and effects of perfluoroalkyl substances in three hydroponically grown Salix L. species
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-14
    Nisha Sharma; Giuseppe Barion; Inisa Shrestha; Leonard Barnabas Ebinezer; Anna Rita Trentin; Teofilo Vamerali; Giustino Mezzalira; Antonio Masi; Rossella Ghisi
    更新日期:2020-01-15
  • Fish response of metal bioaccumulation to reduced toxic load on long-term contaminated lake Imandra
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-15
    Natalia A. Gashkina; Tatyana I. Moiseenko; Lubov P. Kudryavtseva

    The present study analysed the response of whitefish (Coregonus lavaretus L.) to reduced toxicity after the long-term contamination of subarctic Lake Imandra. High concentrations of Ni, Al, and Sr in fish organs and tissues were accompanied by nephrocalcinosis, scoliosis, and myopathy during the period of intense contamination. After reduction of the toxic impact on the lake, the accumulation of Cu, Al, Sr, Cr, Pb, and Hg in the kidney, which is the target organ for toxicity, was two-fold less and that of Cd was 10-fold less in whitefish from the contaminated part of the lake compared with those in whitefish from the non-contaminated parts of the lake. The ecological success of whitefish from the contaminated part of the lake was associated with the limited accumulation of metals in organs and tissues and a more favourable physiological state compared with whitefish from non-contaminated parts of the lake. Redistribution models were constructed for essential and non-essential metals in the fish liver and kidney depending on the physiological state of fish. The results revealed changes in Fe and Zn metabolism: an increase in Fe and a decrease in Zn accumulation in the liver with increasing stage of liver disease and decreasing blood haemoglobin concentration. Furthermore, under the sub-toxic (except for Cu) conditions of Lake Imandra, the strategy of adaptive fish response is to preserve and maintain acid–base regulation system.

    更新日期:2020-01-15
  • Acute toxicity assessment of arsenic, chromium and almix 20WP in Euphlyctis cyanophlyctis tadpoles
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-15
    Palas Samanta; Sandipan Pal; Aloke Kumar Mukherjee; Apurba Ratan Ghosh

    Heavy metals and herbicide are gaining serious environmental concern in aquatic toxicology due to its adverse effects on aquatic organisms especially amphibians. Accordingly, present study first time evaluated the acute toxicity of two heavy metals [arsenic (As3+) and chromium (Cr6+)] and a herbicide (Almix) to Indian skittering frog tadpole, Euphlyctis cyanophlyctis. The LC50 values of As, Cr and Almix for 24, 48, 72 and 96 h were 73.58, 56.31, 43.58 and 32.58 mg L−1; 326.68, 224.31, 171.92 and 141.99 mg L−1; and 1297.85, 1148.22, 1033.62 and 955.17 mg L−1, respectively. It also revealed the concentration- and time-dependent increased mortality rate under these toxicants. The safety concentrations (SC) of As, Cr and Almix to tadpoles were 3.26, 14.20 and 95.52 mg L−1, respectively. The findings disclosed that As is highly toxic to E. cyanophlyctis than Cr and Almix. Alkaline phosphatase (ALP) activity showed varied responses to exposed chemicals. In particularly, ALP activity reduced significantly for Cr treatment. Glutathione S-transferase (GST) activity in E. cyanophlyctis was significantly inhibited by As treatment (p < 0.05); however, GST activity was remain unchanged for Cr and Almix (p > 0.05). The As toxicity correlates positively with GST inhibition (r = 0.779, p < 0.01); contrarily, Cr and Almix revealed negative correlation with GST induction (r = −0.461 and −0.19, respectively; p > 0.05). This result indicated that GST play a crucial role for regulating the tadpole mortality and intoxication by As, Cr and Almix. Overall, our findings demonstrate the different levels of toxic sensitivity (adverse effects) under different toxicants on E. cyanophlyctis tadpoles. Finally, the present findings could be used as baseline information of toxicosis for metalloid, heavy metal and herbicide exposures in wild frog populations.

    更新日期:2020-01-15
  • A review on control factors of pyrolysis technology for plants containing heavy metals
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-14
    Zhongchuang Liu; Li-ao Wang; Hongyan Xiao; Xiaowei Guo; Oksana Urbanovich; Liubov Nagorskaya; Xiang Li
    更新日期:2020-01-15
  • A sensitive sensor based on MOFs derived nanoporous carbons for electrochemical detection of 4-aminophenol
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-15
    Sisi Chen; Runmin Huang; Jiao Zou; Dan Liao; Jingang Yu; Xinyu Jiang
    更新日期:2020-01-15
  • Effect of pH on the adsorption of arsenic(V) and antimony(V) by the black soil in three systems: Performance and mechanism
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-15
    Yurui Fan; Chunli Zheng; Hongxia Liu; Chi He; Zhenxing Shen; Tian C. Zhang
    更新日期:2020-01-15
  • ROS-mediated miR-21-5p regulates the proliferation and apoptosis of Cr(VI)-exposed L02 hepatocytes via targeting PDCD4
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-15
    Yujing Zhang; Yuanyuan Xiao; Yu Ma; Ningjuan Liang; Yuehui Liang; Chan Lu; Fang Xiao

    Although much has been determined about the molecular mechanisms of hexavalent chromium [Cr(VI)]-induced hepatotoxicity, more remains to be explored. In particular, explicit epigenetic alterations of microRNAs (miRNAs) which can negatively regulate mRNAs at post transcriptional level remain understudied. In the present study, cell apoptosis was determined using Annexin V/propidium iodide (PI) staining, while proliferative growth was analyzed by colony formation assay and proliferating cell nuclear antigen (PCNA) detection. miRNA microarray was performed to compare the global miRNAs expression patterns. miR-21-5p mimics (mi)/inhibitor (in), and PDCD4-siRNAs were transfected into L02 hepatocytes. Our results revealed that Cr(VI) induced apoptosis and inhibited proliferation in L02 hepatocytes via reactive oxygen species (ROS), the formation of which is closely related to mitochondrial damage, especially the inhibition of mitochondrial respiratory chain complex (MRCC). We also confirmed that ROS-mediated miR-21-5p inhibition participated in cell apoptosis and proliferative inhibition induced by Cr(VI). Furthermore, programmed cell death protein 4 (PDCD4), the up-regulation of which was related to ROS over-production, was predicted and verified as a target of miR-21-5p. Transcription factor PDCD4 silencing suppressed apoptosis and stimulated cell proliferation. In conclusion, from the perspective of epigenetics, the present study revealed that ROS-mediated miR-21-5p regulated the proliferation and apoptosis of Cr(VI)-exposed L02 hepatocytes via targeting PDCD4, which provided the new targets for molecular intervention and treatment of liver damage in Cr(VI)-exposed population.

    更新日期:2020-01-15
  • Associations between fine particulate matter constituents and daily cardiovascular mortality in Shanghai, China
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-15
    Cuiping Wang; Lipeng Hao; Cong Liu; Renjie Chen; Weidong Wang; Yichen Chen; Yining Yang; Xia Meng; Qingyan Fu; Zhekang Ying; Haidong Kan
    更新日期:2020-01-15
  • Health risk assessment and bioaccessibilities of heavy metals for children in soil and dust from urban parks and schools of Jiaozuo, China
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-15
    Qiao Han; Mingshi Wang; Jingli Cao; Chenlu Gui; Yanping Liu; Xiangdong He; Yuchuan He; Yang Liu
    更新日期:2020-01-15
  • Does nitrogen source influence cadmium distribution in Arabidopsis plants?
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-14
    Analía Vazquez; Laura Recalde; Andrea Cabrera; María Daniela Groppa; María Patricia Benavides

    The purpose of the present work was to study the effect of the nitrogen source (NO3- vs NH4+) on cadmium (Cd) uptake, translocation and partition and its associated toxicity in hydroponically-grown Arabidopsis plants. After a short growth period on a complete Hoagland nutrient solution, Arabidopsis seedlings continued in the same growth medium (NA) or were switched to NO3– (N) or NH4+ (A) as sole N sources and supplied with 2.5 μM Cd. Unrelated to the nitrogen source, Cd reached higher levels in roots than in leaves. However, when ammonium was the source of nitrogen, Cd accumulation in roots was lower than in N or NA medium and the metal translocation to the aerial part was restricted, reaching values 25%–35% below the levels observed in plants grown with N or NA. Cadmium negatively affected chlorophyll content and PSII quantum yield, independently of the nitrogen source, with the highest decrease (35%) under NA treatment. Proline content increased, either with NA, N or A supplied in the presence of Cd, whereas a rise in total anthocyanin content was clearly favored when ammonium was the source of nitrogen, with or without Cd. In leaves, while NIA1 and NIA2 expression was markedly reduced by Cd in the presence of N or NA, ammonium source slightly reduced NIA1 expression but greatly upregulated NIA2 expression upon Cd exposure. The decay in NR activity was independent of the nitrogen source when Cd was applied and this decay was accompanied by a great increase in NH4+ levels either with nitrates or ammonium in the medium in the presence of Cd. Only NIA1 was detected in roots and its expression, together with NR activity and nitrates levels, was the highest in N medium devoid of Cd. The possibility of reducing Cd health risks through nitrogen fertilization practices is discussed.

    更新日期:2020-01-14
  • 更新日期:2020-01-14
  • 更新日期:2020-01-14
  • Bioaccumulation, biodistribution,and depuration of 13C-labelled fullerenols in zebrafish through dietary exposure
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-11
    Qiuyue Shi; Han Zhang; Chenglong Wang; Hongyun Ren; Changzhou Yan; Xian Zhang; Xue-Ling Chang
    更新日期:2020-01-13
  • Laccase mediator system obtained from a marine spore exhibits decolorization potential in harsh environmental conditions
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-11
    Elaheh Asadi; Ali Makhdoumi; Ahmad Asoodeh

    Laccases play a significant role in remedying dye pollutants. Most of these enzymes are originated from terrestrial fungi and bacteria, thus they are not proper to be used in the environments with neutral/alkaline pH, or they may require laborious extraction/purification steps. These limitations can be solved using marine spore laccases through high stability and easy to use application. In the current study, laccase activity of the marine spore -forming Bacillus sp. KC2 was measured according to the guaiacol and syringaldazine oxidation. Abiotic stresses like pH of 6, temperature of 37 °C and 0.3 mM CuSO4 (in comparison with optimal sporulation conditions: pH of 8, temperature of 20 °C and 0.0 mM CuSO4) enhanced laccase formation in sporal coat. Maximum activity of enzyme was observed at 50 °C and pH 7, which did not change in the alkaline pH and temperature range of 20–70 °C. Results indicated ions, inhibitors and solvent stability of the enzyme and its activity were stimulated by Co2+, Mn2+, PMSF, acetone, acetonitrile, ethanol, and methanol. The spore laccase could decolorize synthetic dyes from various chemical groups including azo (acid orange, amaranth, trypan blue, congo red, and amido black), indigo (indigo carmine), thiazine (methylene blue, and toluidine blue), and triarylmethane (malachite green) with ABTS/syringaldazine mediators after 5 h. Degradation products were not toxic against Sorghum vulgare and Artemia salina model organisms. The enzyme mediator system showed high potentials for dye bioremediation over a wide range of harsh conditions.

    更新日期:2020-01-13
  • Investigating photo-driven arsenics’ behavior and their glucose metabolite toxicity by the typical metallic oxides in ambient PM2.5
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-11
    Na Zhu; Ying Li; Junheng Jiao; Yang Yun; Tingting Ku; Dong Liang; Nan Sang

    It is essential and challenged to understand the atmospheric arsenic pollution because it is much more complicated than in water and top-soil. Herein the different behavior of arsenic species firstly were discovered within the ambient PM2.5 collected during daytime and nighttime, winter and summer. The diurnal variation of arsenic species in PMs is significantly correlated with the presence of metallic oxides, specifically, ferrous, titanium and zinc oxides, which might play a key role in the process of the photo-oxidation of As(III) to As(V) with the meteorological parameters and regional factors excluded. Subsequently, the photo conversion of arsenite was detected on metal-loaded glass-fiber filters under visible light. The photo-generated superoxide radical was found to be predominantly responsible for the oxidation of As(III). In order to reveal toxicity differences induced by oxidation As(III), HepG2 cells were exposed to various arsenic mixture solution. We found that the antioxidant enzyme activities suppressed with increasing the As(III)/As(V) ratio in total, followed by the accumulation of intracellular ROS level. The glucose consumption and glycogen content also displayed an obvious reduction in insulin-stimulated cells. Compared to the expression levels of IRS-1, AKT and GLUT4, GLUT2 might be more vulnerable to arsenic exposure and lead to the abnormalities of glucose metabolism in HepG2 cells. Taken together, these findings clarify that the health risk posed by inhalation exposure to As-pollution air might be alleviated owing to the photo-driven conversion in presence of metal oxides.

    更新日期:2020-01-13
  • Human arsenic exposure and lung function impairment in coal-burning areas in Guizhou, China
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-08
    Wenjuan Wang; Qingling Wang; Zhonglan Zou; Fanyan Zheng; Aihua Zhang

    To evaluate the effect of coal-burning arsenic (As) exposure on lung function and the potential underlying mechanisms, a total of 217 As-exposed subjects and 75 reference subjects were recruited into this study. Hair arsenic (H–As), pulmonary function tests, and serum inflammatory markers CC16, SP-A, MMP-9, and TIMP-1 were evaluated. Residents from As-exposed areas showed higher H–As concentrations (median 0.25 μg/g) than subjects from the reference area (median 0.14 μg/g). Large reductions in lung function parameters were noted in the As-exposed group. A significant negative correlation was observed between H–As concentrations and lung function. Specifically, monotonic negative dose-response relationships were observed between H–As and FEV1(%), FEV1/FVC (%) and FEF75 (%) (all P < 0.05), while the associations between H–As and FVC (%), FEF25 (%), and FEF50 (%) were nonlinear (P for nonlinearity = 0.03, 0.001, 0.01, respectively). In addition, there was a direct positive relationship between H–As and the inflammatory response. Alterations in inflammatory biomarkers (CC16, SP-A, MMP-9, and MMP-9/TIMP-1) were significantly associated with As-induced lung function impairment. Thus, this population-based study revealed that As exposure has significant toxic effects on lung function and increased inflammation may occur during this toxic process. We provide scientific evidence for an As-induced alteration in inflammatory biomarkers and pulmonary damage in an As-exposed population. The results of this study can inform risk assessment and risk control processes in relation to human As exposure in coal-burning arsenicosis areas.

    更新日期:2020-01-09
  • Nitric oxide is involved in nano-titanium dioxide-induced activation of antioxidant defense system and accumulation of osmolytes under water-deficit stress in Vicia faba L.
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-09
    M. Nasir Khan; Mazen A. AlSolami; Riyadh A. Basahi; Manzer H. Siddiqui; Asma A. Al-Huqail; Zahid Khorshid Abbas; Zahid H. Siddiqui; Hayssam M. Ali; Faheema Khan
    更新日期:2020-01-09
  • 更新日期:2020-01-09
  • Exogenous jasmonic acid decreased Cu accumulation by alfalfa and improved its photosynthetic pigments and antioxidant system
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-09
    Huiping Dai; Shuhe Wei; Marta Pogrzeba; Szymon Rusinowski; Jacek Krzyżak; Genliang Jia

    Jasmonic acid (JA) is an important phytohormone, which among others may be involved in the regulation of plant accumulating heavy metal. This experiment was designed to explore the effects of exogenous JA on the responses of alfalfa to Cu stress (100 μM) in Hoagland solution. When 1, 5 or 10 mM JA was added to the treatment with Cu addition, Cu concentrations in roots and leaves of alfalfa were significantly decreased (p < 0.05) to some extents compared to the treatment without JA addition. The biomasses of roots and leaves of alfalfa in treatments of JA additions were significantly increased (p < 0.05) compared to the Cu stress treatment. Similarly, the concentrations of Chlorophyll, antioxidant enzyme activities, MDA and H2O2 were improved accordingly. But these factors of JA were not improved further when its concentration added in media was the highest (10 mM), indicating its improvement roles were limited. These results suggested that there were positive roles of exogenous JA on alfalfa decreased its Cu accumulation and toxicities might via reduced oxidative stress.

    更新日期:2020-01-09
  • Chlorophyll synthesis and the photoprotective mechanism in leaves of mulberry (Morus alba L.) seedlings under NaCl and NaHCO3 stress revealed by TMT-based proteomics analyses
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-08
    Zhang Huihui; Wang Yue; Li Xin; He Guoqiang; Che Yanhui; Teng Zhiyuan; Shao Jieyu; Xu Nan; Sun Guangyu

    Chlorophyll (Chl) and effective photoprotective mechanism are important prerequisites to ensure the photosynthetic function of plants under stress. In this study, the effects of 100 mmol L−1 NaCl and NaHCO3 stress on chlorophyll synthesis and photosynthetic function of mulberry seedlings were studied by physiological combined with proteomics technology. The results show that: NaCl stress had little effect on the expression of Chl synthesis related proteins, and there were no significant changes in Chl content and Chl a:b ratio. However, 13 of the 15 key proteins in the process of Chl synthesis were significantly decreased under NaHCO3 stress, and the contents of Chl a and Chl b were significantly decreased (especially Chl a). Although stomatal conductance (Gs) decreased significantly under NaCl stress, net photosynthetic rate (Pn), PSII maximum photochemical efficiency (Fv/Fm) and electron transfer rate (ETR) did not change significantly, but under NaHCO3 stress, not only Gs decreased significantly, PSII activity and photosynthetic carbon were the same. In the photoprotective mechanism under NaCl stress, NAD(P)H dehydrogenase (NDH)-dependent cyclic electron flow (CEF) enhanced, the expression of related proteins subunit, ndhH, ndhI, ndhK, and ndhM, the key enzyme of the xanthophyll cycle, violaxanthin de-epoxidase (VDE) were up-regulated, the ratio of (A + Z)/(V + A + Z) and non-photochemical quenching (NPQ) was increased. The expressions of proteins FTR and Fd-NiR were also significant up-regulated under NaCl stress, Fd-dependent ROS metabolism and nitrogen metabolism can effectively reduce the electronic pressure on Fd. Under NaHCO3 stress, the expressions of NDH-dependent CEF related proteins subunit (ndhH, ndhI, ndhK, ndhM and ndhN), VDE, ZE, FTR, Fd-NiR and Fd-GOGAT, were significant down-regulated, and ZE, CP26, ndhK, ndhM, Fd-NiR, Fd-GOGAT and FTR genes expression also significantly decreased, the photoprotective mechanism, like the xanthophyll cycle,CEF and Fd-dependent ROS metabolism and nitrogen metabolism might be damaged, resulting in the inhibition of PSII electron transfer and carbon assimilation in mulberry leaves under NaHCO3 stress.

    更新日期:2020-01-08
  • Genotypic variation for cadmium tolerance in common bean (Phaseolus vulgaris L.)
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-08
    Ramin Bahmani; Mahsa Modareszadeh; Mohammad reza Bihamta
    更新日期:2020-01-08
  • Development of pp-LFER and QSPR models for predicting the diffusion coefficients of hydrophobic organic compounds in LDPE
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-08
    Tengyi Zhu; Yue Jiang; Haomiao Cheng; Rajendra Prasad Singh; Bipeng Yan
    更新日期:2020-01-08
  • Transcriptomic profiling identifies a critical role of Nrf2 in regulating the inflammatory response to fly ash particles in mouse lung
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-06
    Jingwen Zhang; Huiling Cui; Akhileshwar Namani; Jun Yao; Hong Deng; Xiuwen Tang; Xiu Jun Wang
    更新日期:2020-01-07
  • 更新日期:2020-01-07
  • Effects of metal contamination on liver in two fish species from a highly impacted neotropical river: A case study of the Fundão dam, Brazil
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-06
    André Alberto Weber; Camila Ferreira Sales; Francisco de Souza Faria; Rafael Magno Costa Melo; Nilo Bazzoli; Elizete Rizzo

    Environmental disasters such as the rupturing of mine tailings dams are a major concern worldwide. In the present study, we assess the effects of the release of mine waste due to the rupture of the Fundão dam on two native fish species (Hoplias intermedius and Hypostomus affinis) from the Doce River basin. Two sampling sites were chosen: S1, a reference site, and S2, contaminated by mining waste. Water and sediment were collected to evaluate metals concentration. Adult fish were caught to analyse biological parameters, hepatic histopathology, and biomarkers of metal contamination. Compared to site S1, the concentration of manganese was statistically higher in water while lead, nickel, and arsenic were statistically higher in the sediment from site S2, and iron had no significant difference between sites. At site S1, fish of both species presented hepatic tissue with normal architecture. At site S2, hepatic alterations, such as cytoplasmic vacuolization and necrosis were frequently found in both species. Regarding the histopathological index, higher values were found in both species from site S2. The positive antibody reactions for cytochrome P450 1A (CYP1A) and metallothionein (MT) were statistically greater in site S2 for both species. The oxidative stress biomarkers, superoxide dismutase (SOD) and catalase (CAT) were statistically higher in H. intermedius from site S2, but only CAT was statistically greater in H. affinis at site S2. These results demonstrate that the release of mineral residues from the rupture of the Samarco mine dam is provoking hepatic damage in the fish from the Doce River besides inducing the expression of proteins and enzymes related to metal contamination.

    更新日期:2020-01-07
  • Selenium toxicity in upland field-grown rice: Seed physiology responses and nutrient distribution using the μ-XRF technique
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-07
    André Rodrigues dos Reis; Eduardo Henrique Marcandalli Boleta; Charline Zaratin Alves; Mayara Fávero Cotrim; Julierme Zimmer Barbosa; Vinícius Martins Silva; Rafael Lawandovski Porto; Maria Gabriela Dantas Bereta Lanza; José Lavres; Marcos Henrique Feresin Gomes; Hudson Wallace Pereira de Carvalho

    Selenium (Se) is an essential element for human and animal, although considered beneficial to higher plants. Selenium application at high concentration to plants can cause toxicity decreasing the physiological quality of seeds. This study aimed to characterize the Se toxicity on upland rice yield, seed physiology and the localization of Se in seeds using X-ray fluorescence microanalysis (μ-XRF). In the flowering stage, foliar application of Se (0, 250, 500, 1000, 1500, 2000 g ha−1) as sodium selenate was performed. A decrease in rice yield and an increase in seed Se concentrations were observed from 250 g Se ha−1. The storage proteins in the seeds showed different responses with Se application (decrease in albumin, increase in prolamin and glutelin). There was a reduction in the concentrations of total sugars and sucrose with the application of 250 and 500 g Se ha−1. The highest intensities Kα counts of Se were detected mainly in the endosperm and aleurone/pericarp. μ-XRF revealed the spatial distribution of sulfur, calcium, and potassium in the seed embryos. The seed germination decreased, and the electrical conductivity increased in response to high Se application rates showing clearly an abrupt decrease of physiological quality of rice seeds. This study provides information for a better understanding of the effects of Se toxicity on rice, revealing that in addition to the negative effects on yield, there are changes in the physiological and biochemical quality of seeds.

    更新日期:2020-01-07
  • Long-term exposure to copper induces autophagy and apoptosis through oxidative stress in rat kidneys
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-06
    Fang Wan; Gaolong Zhong; Zhijun Ning; Jianzhao Liao; Wenlan Yu; Congcong Wang; Qingyue Han; Ying Li; Jiaqiang Pan; Zhaoxin Tang; Riming Huang; Lianmei Hu
    更新日期:2020-01-07
  • 更新日期:2020-01-07
  • Heavy metal toxicity in the water column and benthic sediments of a degraded tropical stream
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-06
    Emmanuel O. Akindele; Omobukola D. Omisakin; Oluwagbemiga A. Oni; Olanrewaju O. Aliu; Gbenga E. Omoniyi; Oluwaseun T. Akinpelu

    Agriculture and other anthropogenic activities on riparian corridors pose a great ecotoxicological risk to freshwater ecosystem and human health. Using the atomic absorption spectroscopy, concentrations of heavy metals (Cd, Cu, Fe, Zn, Pb and As) in the water column and benthic sediments of a degraded tropical stream (Opa Stream, Ile-Ife, Nigeria), were assessed with a view to determining the stream's health status. Three metals (Cu, Pb, and As) showed significant positive correlations between concentrations in the water column and the benthic sediments. All but one heavy metal (i.e. Zn) had reached disturbing concentrations in the stream's water column and exceeded their recommended limits in surface freshwaters. The geo-accumulation index (Igeo) and contamination factor (CF) indicated that the stream was moderately contaminated with Cd (0

    更新日期:2020-01-07
  • Puerarin enhance vascular proliferation and halt apoptosis in thiram-induced avian tibial dyschondroplasia by regulating HIF-1α, TIMP-3 and BCL-2 expressions
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-07
    Muhammad Waqas; Hammad Qamar; Jialu Zhang; Wangyuan Yao; Aoyun Li; Yaping Wang; Mudassar Iqbal; Khalid Mehmood; Xiong Jiang; Jiakui Li

    Tetramethyl thiuram disulfide (thiram) is a dithiocarbamate pesticide used for crop protection and storage. But, it's widespread utilization is associated with deleterious growth plate cartilage disorder in broilers termed as avian tibial dyschondroplasia (TD). TD results in non-mineralized and less vascularized proximal tibial growth plate cartilage causing lameness and poor growth performance. This study investigated the therapeutic potential of puerarin against thiram toxicity in TD affected chickens. One-day-old broiler chickens (n = 240) were alienated into three equal groups i.e. control, TD and puerarin (n = 80) and were offered standard feed. Additionally, TD and puerarin groups were offered thiram at 50 mg/kg of feed from 4 to 7 days for TD induction followed by puerarin therapy at 120 mg/kg to puerarin group only from 8 to 18 days for TD treatment. Thiram feeding to TD and puerarin group chickens caused lameness, mortality, and increased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), malondialdehyde (MDA) levels and growth plate (GP) size and upregulated HIF-1α expression. Besides, the production parameters, alkaline phosphatase (ALP), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels and the expressions of TIMP-3 and BCL-2 were decreased (p < 0.05). Puerarin alleviated lameness, enhanced angiogenesis and growth performance and serum and antioxidant enzymes, decreased apoptosis and recuperated GP width by significantly downregulating HIF-1α and upregulating the TIMP-3 and BCL-2 mRNA and protein expressions in puerarin group chickens (p < 0.05). In conclusion, the toxic effects associated with thiram can be mitigated using puerarin.

    更新日期:2020-01-07
  • Enhanced bioremediation of lindane-contaminated soils through microbial bioaugmentation assisted by biostimulation with sugarcane filter cake
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-06
    Enzo E. Raimondo; Juan D. Aparicio; Ana L. Bigliardo; María S. Fuentes; Claudia S. Benimeli

    Lindane is a toxic and persistent organochlorine pesticide, whose extensive use generated its accumulation in different environmental matrices. Bioremediation is a promising technology that can be used combining bioaugmentation and biostimulation processes to soil restoration. The aim of the present work was to determine the conditions of maximum lindane removal by bioaugmentation with an actinobacteria consortium and biostimulation with sugarcane filter cake (SCFC). The assays were carried out on lindane-contaminated silty loam (SLS), clayey (CS), and sandy (SS) soils. Through complete factorial designs, the effects of three abiotic factors (moisture content, proportion and size of SCFC particles) were evaluated on lindane removal. In addition, a response optimizer determined the optimal conditions for pesticide removal in bioaugmented and biostimulated soils, in the range of levels studied for each factor. In these conditions, bioaugmentation of biostimulated soils increased the pesticide removal (SLS: 61.4%, CS: 70.8%, SS: 86.3%), heterotrophic microbial counts, and soil enzymatic activities, and decreased lindane T1/2, regarding the non-bioaugmented biostimulated controls, after 14 days of assay. The values of these parameters confirmed the efficiency of the bioremediation process. Finally, the viability of the four strains was demonstrated at the end of the assay. The results indicate that the simultaneous application of bioaugmentation with the actinobacteria consortium and biostimulation with SCFC constitutes a promising tool for restoring soils contaminated with lindane, by using the optimal conditions obtained through the factorial designs.

    更新日期:2020-01-07
  • 更新日期:2020-01-07
  • In vitro lung and gastrointestinal bioaccessibility of potentially toxic metals in Pb-contaminated alkaline urban soil: The role of particle size fractions
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-07
    Xiaoping Li; Yu Gao; Meng Zhang; Yu Zhang; Ming Zhou; Liyuan Peng; Ana He; Xu Zhang; Xiangyang Yan; Yanhua Wang; Hongtao Yu
    更新日期:2020-01-07
  • Acute oral methylmercury exposure perturbs the gut microbiome and alters gut-brain axis related metabolites in rats
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-07
    Xiaoying Lin; Jiating Zhao; Wei Zhang; Lina He; Liming Wang; Dunhu Chang; Liwei Cui; Yuxi Gao; Bai Li; Chunying Chen; Yu-Feng Li

    Environmental pollutants like methylmercury (MeHg) can bring devastating neurotoxicity to animals and human beings. Gut microbiota has been found to demethylate MeHg and promote the excretion of Hg through feces. However, the impacts of MeHg on gut microbiota and metabolites related to gut-brain interactions were less studied in mammals. The object of this study was to investigate the impacts of acute MeHg exposure on gut microbiome and metabolites together with its impact on gut integrity and related biological responses in rats. Rats were exposed to MeHg through oral administration and were sacrificed after 24 h 16 S rRNA gene sequencing was used to study the perturbance to gut microbiome and liquid chromatography mass spectrometry (LC-MS) was used for metabolomics profiling. It was found that gut was one of the target tissues of MeHg. MeHg induce the changes of intestinal microbial community structure and induce the regulating neuron activity change of intestinal neurotransmitters and metabolites on intestinal neurotransmitters and metabolites regulating the neuron activity. This was supported by the increased BDNF level. These findings may suggest a potential new mechanism regarding the neurotoxicity of MeHg. The protocols used in this study may also be applied to understand the neurotoxicity of other environmental neurotoxins like Pb, Mn, polychlorinated biphenyls, and pesticides, etc and to screen the neurotoxicity of emerging environmental contaminants.

    更新日期:2020-01-07
  • Epigenetic dysregulation of Mdr1b in the blood-testis barrier contributes to dyszoospermia in mice exposed to cadmium
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-06
    Yu Fang; Ying Xiang; Xing Lu; Xin Dong; Jiexin Zhang; Shan Zhong
    更新日期:2020-01-06
  • Identification and characterization of a novel phthalate-degrading hydrolase from a soil metagenomic library
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-06
    Jiarong Qiu; Yueqi Zhang; Yaning Shi; Junwei Jiang; Shenglu Wu; Longxiang Li; Yuting Shao; Zhihong Xin
    更新日期:2020-01-06
  • Comparative transcriptome analysis reveals Dusp1 as a critical regulator of inflammatory response to fly ash particle exposure in mouse
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-06
    Jingwen Zhang; Yiping Chen; Akhileshwar Namani; Mohamed Elshaer; Zhinong Jiang; Hongfei Shi; Xiuwen Tang; Xiu Jun Wang
    更新日期:2020-01-06
  • The effects of 1-hexyl-3-methylimidazolium bromide on embryonic development and reproduction in Daphnia magna
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-03
    Miao Yu; Chuanhu Liu; Honghao Zhao; Yanjing Yang; Jinhui Sun

    Ionic liquids (ILs) are acknowledged as green chemicals and favorable substitutes for volatile organic solvents, which are currently used. However, previous studies have shown that these compounds had toxicological impacts on aquatic organisms. To investigate the effects of 1-hexyl-3- methylimidazolium bromide ionic liquid ([C6mim]Br) on embryonic development and reproduction in water flea (Daphnia magna), a series of exposure experiments were conducted, including acute toxicity, maternal exposure, and chronic exposure tests. In acute toxicity experiment, D. magna neonates exhibited developmental abnormalities in the shell spine and the second antennae in a concentration-dependent manner after exposure to [C6mim]Br. The results in maternal exposure test also revealed a certain embryo-toxicity in response to [C6mim]Br in D. magna. However, the toxicity was lower than that conveyed by direct acute exposure, this indicated that the IL could act directly on organism. During the 21 days chronic exposure, the 1.6 mg/L exposure caused marked drop in the survival, molts and the number of the first brood of D. magna. Meanwhile, the total number of offspring was significantly declined in 1.6 mg/L concentration treatment groups, whereas increased in 0.2 mg/L groups. Generally, abnormalities in the offspring were significantly increased across all of the treatment groups in contrast to the control. No effect on sex differentiation was found during the experiments. These findings suggested that [C6mim]Br could affect embryonic development and reproduction in D. magna, and provided references for further study on the mechanisms underlying toxicological effects of ILs and the assessment of their potential environmental risks.

    更新日期:2020-01-04
  • 更新日期:2020-01-04
  • Fabrication of CdS-SBA-15 nanomaterials and their photocatalytic activity for degradation of salicylic acid under visible light
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-03
    Junhong Wang; Xianzhao Shao; Junhai Liu; Xiaohui Ji; Jianqi Ma; Guanghui Tian
    更新日期:2020-01-04
  • Microcystins-LR induced apoptosis via S-nitrosylation of GAPDH in colorectal cancer cells
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-02
    Keyi Li; Mengqiu Huang; Pengfei Xu; Meng Wang; Shuangyan Ye; Qianli Wang; Sisi Zeng; Xi Chen; Wenwen Gao; Jianping Chen; Qianbing Zhang; Zhuo Zhong; Yang Sun; Qiuzhen Liu

    Microcystins-LR (MC-LR), a cyanobacterial toxins, initiate apoptosis in normal and tumor cells. Nitric oxide produced by iNOS is necessary for MC-LR-induced apoptosis. However, the underlying mechanism of NO mediated MC-LR cytotoxicity remains unclear. Here, we performed in vitro experiments on MC-LR cytotoxicity associated with NO induced S-nitrosyation of GAPDH in human colon cancer cells SW480. MTT assay indicated that MC-LR decreased the cellular viability by high concentration (>1 μM). Flow cytometer assay revealed that apoptosis was core mode for MC-LR cytotoxicity. Griess assay showed that MC-LR exposure increased the release of NO through the function of NOS1 and NOS2 in SW480 cells. In turn, NO stress induced the S-nitrosylated modification of GAPDH leading to its nuclear translocation following Siah1 binding. CHIP assay showed that the nuclear GADPH increased P53 transcript of a panner of apoptosis related genes. Moreover, apoptosis induced by MC-LR could be reduced by GAPDH or si-Siah1 or NOSs inhibitor, L-NAME. Thus, our study verified a molecular mechanism of NO/GAPDH/Siah1 cascade in MC-LR mediated apoptosis in colorectal cancer cells, providing a further understanding the in vitro molecular mechanism of MC-LR colorectal toxicity.

    更新日期:2020-01-02
  • Decreased malondialdehyde levels in fish (Astyanax altiparanae) exposed to diesel: Evidence of metabolism by aldehyde dehydrogenase in the liver and excretion in water
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-02
    Danielly Garcia; Daína Lima; Danilo Grünig Humberto da Silva; Eduardo Alves de Almeida

    Increased malondialdehyde (MDA) levels are commonly considered an indicator of lipid peroxidation derived from oxidative stress insults promoted by exposure of fish to pollutants. However, a decrease in MDA levels after xenobiotic exposure has been also reported, an effect that is mostly attributed to enhanced antioxidant defenses. In this study, we assessed whether pollutant-mediated MDA decrease would be associated with antioxidant enhancement or with its metabolism by aldehyde dehydrogenase (ALDH) in the liver and gills of lambari (Astyanax altiparanae) exposed to diesel oil (0.001, 0.01, and 0.1 mL/L). MDA levels were decreased in the liver of lambari exposed to diesel. The activities of the antioxidant enzymes, catalase (CAT) and glutathione peroxidase (GPx), were unchanged in the liver, while that of glucose-6-phosphate dehydrogenase (G6PDH) was decreased. In contrast, levels of total glutathione (tGSH) and the activity of glutathione S-transferase (GST) were increased in the liver, which partly support antioxidant protection against lipid peroxidation. More importantly, ALDH activity increased in a concentration-dependent manner, being negatively correlated with MDA levels, indicating MDA metabolism by ALDH. In the gills, diesel exposure increased MDA and lipid hydroperoxide levels, and promoted increases in antioxidant defenses, indicating oxidative stress. Curiously, ALDH activity was undetectable in the gills, supporting the possibility of direct MDA excretion in the water by the gills. Analyses of MDA in the water revealed increased levels of MDA in the aquaria in which the fish were exposed to diesel, compared to control aquaria. A second experiment was carried out in which the fish were intraperitoneally injected with MDA (10 mg/kg) and analyzed after 1, 6, and 12 h. MDA injection caused a time-dependent decrease in hepatic MDA levels, did not alter ALDH, CAT, GPx, and GST activities, and decreased G6PDH activity and tGSH levels. In the gills, MDA injection caused a slight increase in MDA levels after 1 h, but did not alter GPx, G6PDH, and GST activities. MDA injection also enhanced CAT activity and tGSH levels in the gills. MDA concentration in water increased progressively after 1, 6, and 12 h, supporting the hypothesis of direct MDA excretion as an alternative route for MDA elimination in fish. Our results suggest that the decreased MDA levels after exposure of lambari to diesel oil pollutant probably reflects an association between enhanced antioxidant protection, MDA metabolism, and MDA excretion in water.

    更新日期:2020-01-02
  • 更新日期:2020-01-02
  • Effects of Fe-oxidizing bacteria (FeOB) on iron plaque formation, As concentrations and speciation in rice (Oryza sativa L.)
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2020-01-02
    Anwen Xiao; Wai Chin Li; Zhihong Ye

    Large areas of the paddy fields in South China are contaminated with arsenic (As), which causes serious problems, including high As concentrations in brown rice. Three As-resistant iron-oxidizing bacteria (FeOB) namely, Bacillus sp. T2, Pseudomonas sp. Yangling I4 and Bacillus sp. TF1-3, were isolated and applied to rice grown in different As-contaminated environments to study the effects of FeOB on the As accumulation in rice and clarify the possible mechanisms involved. The results showed that FeOB inoculation significantly decreased the inorganic As concentrations in brown rice grown in pots and paddy fields by 3.7–13.3% and 4.6–12.1%, respectively. FeOB inoculation enhanced the formation of Fe plaque, which sequestered more As on the root surface. Moreover, a significantly lower level of As(III) influx was observed in the rice cultivated with FeOB than in the control. FeOB inoculation also decreased the As concentrations in pore water and the Fe(II)/Fe(III) ratio in rhizosphere soil. The present results suggest that FeOB inoculation decreased the inorganic As concentrations in brown rice by affecting the formation of Fe plaque, As(III) uptake kinetics and rhizosphere soil properties. Based on our results, FeOB inoculation could be considered a useful method to decrease inorganic As concentrations in brown rice grown in As-contaminated paddy fields.

    更新日期:2020-01-02
  • 更新日期:2020-01-02
  • 更新日期:2020-01-02
  • 更新日期:2020-01-02
  • 更新日期:2020-01-01
  • 更新日期:2019-12-31
  • Characteristics and ecological risk assessment of polycyclic aromatic hydrocarbons in soil seepage water in karst terrains, southwest China
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2019-12-31
    Yuchuan Sun; Siyu Zhang; Zhenglan Xie; Jiacheng Lan; Tian Li; Daoxian Yuan; Hong Yang; Baoshan Xing
    更新日期:2019-12-31
  • Natural harmine negatively regulates the developmental signaling network of Drosophila melanogaster (Drosophilidae: Diptera) in vivo
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2019-12-31
    Gaofeng Cui; Haiqi Yuan; Zhiyan Jiang; Jing Zhang; Zhipeng Sun; Guohua Zhong
    更新日期:2019-12-31
  • Hazardous effects of urban air particulate matter acute exposure on lung and extrapulmonary organs in mice
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2019-12-31
    Nadia S. Orona; Francisco Astort; Guillermo A. Maglione; Sebastian A. Ferraro; Maximiliano Martin; Celina Morales; Patricia M. Mandalunis; Fernando Brites; Deborah R. Tasat
    更新日期:2019-12-31
  • Prevalence of fluoroquinolone, macrolide and sulfonamide-related resistance genes in landfills from East China, mainly driven by MGEs
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2019-12-31
    Lihua Yao; Yue Li; Zhangqiang Li; Dongsheng Shen; Huajun Feng; Huihua Zhou; Meizhen Wang
    更新日期:2019-12-31
  • Application of algae for heavy metal adsorption: A 20-year meta-analysis
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2019-12-30
    Zeyu Lin; Jing Li; Yaning Luan; Wei Dai

    The use of algae to adsorb heavy metals is an efficient and environmentally friendly treatment for contaminated water and has attracted widespread research attention. In this study, a meta-analysis of the heavy metal adsorption capacity of algae from five different phyla and the factors influencing these capacities was conducted. Phaeophyta was found to have a high heavy metal adsorption capacity, whereas Bacillariophyta had a relatively low adsorption capacity; Chlorophyta, Rhodophyta, and Cyanophyta had moderate adsorption capacities. Non-living algae were more effective in practical applications than living algae were. Algal biomass had a relatively high adsorption efficiency of 1–10 g/L, which did not increase significantly when algal concentration increased. The algal adsorption efficiency for initial heavy metal concentrations of 10–100 mg/L was higher than for concentrations of greater than 100 mg/L. The results further show that algal adsorption of heavy metals reached a maximum capacity of 80–90% within 20 min. Heavy metal adsorption by algae was not temperature-dependent, and it was more effective in moderately to weakly acidic environments (pH = 4–7.5). Considering these aspects for practical applications, algae from some phyla can effectively be used for heavy metal biosorption in contaminated water.

    更新日期:2019-12-30
  • Arsenic (III) or/and copper (II) exposure induce immunotoxicity through trigger oxidative stress, inflammation and immune imbalance in the bursa of chicken
    Ecotox. Environ. Saf. (IF 4.527) Pub Date : 2019-12-30
    Juanjuan Liu; Yu Wang; Hongjing Zhao; Mengyao Mu; Menghao Guo; Xiaopan Nie; Ying Sun; Mingwei Xing

    The environmental hazards of arsenic (As) and copper (Cu) contamination have swept through quite a few districts worldwide. Whereas, molecular mechanisms involved in As- and Cu-induced immunotoxicity in Gallus gallus bursa of Fabricius (BF) are complex and elusive. Male Hy-line chickens were exposed to arsenic trioxide (As2O3; 30 mg/kg) and copper sulfate (CuSO4; 300 mg/kg) alone or in combination, respectively, to examine the potential ecotoxicity of them. The ions homeostasis and BF index of chicken had distinct changes after As or/and Cu exposure. Moreover, As or/and Cu treatment significantly increased the MDA content and NOS activity, and simultaneously resulted in reductions in CAT and AHR activities. Subsequently, it was further exhibited up-regulations of nuclear factor-κB (NF-κB), inflammatory mediators and pro-inflammation cytokines accompanied by depletion of anti-inflammatory cytokines and severe pathological conditions. Moreover, decreased ratio of IFN-γ/IL-4 and increased level of IL-17 illustrated an imbalance of the immune response. Meanwhile, incremental mRNA transcription and protein levels of heat shock proteins (HSPs) alleviated toxicity caused by As or/and Cu. Importantly, exposure to both contaminants significantly soared the BF injury in comparison with exposure to As or Cu alone. All these results illustrated that exposure to As2O3 or/and CuSO4 elicited BF tissue damage and ions changes, and its severity was associated with prolonged persistence of oxidative damage, accompanied by a dysregulated immune response which played a vital role in inflammatory injury. Additionally, combined management of As2O3 and CuSO4 could exacerbate BF injury.

    更新日期:2019-12-30
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