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The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-18 Chang-Yu Song, Chih-Ying Wu, Chih-Yang Lin, Chun-Hao Tsai, Hsien-Te Chen, Yi-Chin Fong, Li-Chai Chen, Chih-Hsin Tang
Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous tissue and is associated with lung metastases. Extracellular vesicles called exosomes are primarily used as mediators of intercellular signal transmission to control tumor metastasis. Visfatin is an adipokine reported to enhance tumor metastasis, but its relationship with exosome generation in chondrosarcoma motility
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Down‐regulating lncRNA KCNQ1OT1 relieves type II alveolar epithelial cell apoptosis during one‐lung ventilation via modulating miR‐129‐5p/HMGB1 axis induced pulmonary endothelial glycocalyx Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Zhenghuan Song, Zhongqiu Wang, Jiaqin Cai, Yihu Zhou, Yueyi Jiang, Jing Tan, Lianbin Gu
ObjectiveEndothelial glycocalyx (EG) maintains vascular homeostasis and is destroyed after one‐lung ventilation (OLV)‐induced lung injury. Long noncoding RNAs (lncRNAs) are critically involved in various lung injuries. This study aimed to investigate the role and regulatory mechanism of KCNQ1 overlapping transcript 1 (KCNQ1OT1) in OLV‐induced lung injury and LPS‐induced type II alveolar epithelial
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Exploring the tumor microenvironment: Chemokine‐related genes and immunotherapy/chemotherapy response in clear‐cell renal cell carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Yuhao Meng, Chen Zhang, Tongfei Fu, Jiaheng He, Junsong Wu, Yongli Zhan
BackgroundThe treatment of clear‐cell renal cell carcinoma (ccRCC) remains challenge. Chemokines laid impact on the proliferation and metastasis of cancer cells. The objective was to identify the chemokine‐related genes and construct a prognostic model for ccRCC.MethodsBulk transcriptomic data (n = 531), single‐cell RNA sequencing (scRNA‐seq) dataset GSE159115, and other validation cohorts were acquired
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LncRNA MRAK052509 competitively adsorbs miR‐204‐3p to regulate silica dust‐induced EMT process Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Liu Xuan, Jiao Zi‐ming, Tian Xue‐yan, Hu Wen‐xuan, Wang Fa‐xuan
Silicosis is a systemic disease caused by long‐term inhalation of free SiO2 and retention in the lungs. At present, it is still the most important occupational health hazard disease in the world. Existing studies have shown that non‐coding RNA can also participate in complex fibrosis regulatory networks. However, its role in regulating silicotic fibrosis is still unclear. In this study, we constructed
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Protein phosphatase 2A modulation and connection with miRNAs and natural products Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Ya‐Ting Chuang, Ching‐Yu Yen, Jen‐Yang Tang, Fang‐Rong Chang, Yi‐Hong Tsai, Kuo‐Chuan Wu, Tsu‐Ming Chien, Hsueh‐Wei Chang
Protein phosphatase 2A (PP2A), a heterotrimeric holoenzyme (scaffolding, catalytic, and regulatory subunits), regulates dephosphorylation for more than half of serine/threonine phosphosites and exhibits diverse cellular functions. Although several studies on natural products and miRNAs have emphasized their impacts on PP2A regulation, their connections lack systemic organization. Moreover, only part
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RSPO2‐associated mitochondrial metabolism defines molecular subtypes with distinct clinical and immune features in esophageal cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Quanzhou Peng, Tianfeng Cao, Xue Yang, Zhujia Ye, Jun Wang, Shang Chen, Yanqi Yu, Yingdian Yu, Wenyuan Xue, Zhiwei Chen, Jianbing Fan
BackgroundEsophageal cancer is a highly aggressive malignancy with limited treatment options and poor prognosis. The identification of novel molecular subtypes and therapeutic targets is crucial for improving clinical outcomes.MethodIn this study, we investigated the role of R‐spondin 2 (RSPO2) in esophageal cancer and its association with mitochondrial metabolism. Using bioinformatics analysis of
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Nickel induces epithelial‐mesenchymal transition in pulmonary fibrosis in mice via activation of the oxidative stress‐mediated TGF‐β1/Smad signaling pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Shanchuan Cao, Heng Yin, Xinglai Li, Xin Zeng, Jingbo Liu
Nickel (Ni) is recognized as a carcinogenic metal, and its widespread use has led to severe environmental and health problems. Although the lung is among the main organs affected by Ni, the precise mechanisms behind this effect remain poorly understood. This study aimed to elucidate the physiological mechanisms underlying Ni‐induced pulmonary fibrosis (PF), using various techniques including histopathological
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TFEB ameliorates DEHP‐induced neurotoxicity by activating GAL3/TRIM16 axis dependent lysophagy and alleviating lysosomal dysfunction Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Hengrui Xing, Panpan Xu, Yue Ma, Tingting Li, Yue Zhang, Xueman Ding, Li Liu, Mulatibieke Keerman, Qiang Niu
Di‐(2‐ethylhexyl) phthalate (DEHP) is a commonly used plasticizer with known neurotoxic effects. However, the specific mechanism underlying this neurotoxicity remains unclear. This study aimed to investigate the role of lysosomal function and lysophagy in DEHP‐induced neurotoxicity, with a particular focus on the regulatory role of Transcription factor EB (TFEB). To achieve this, we utilized in vitro
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Unraveling the role of low‐density lipoprotein‐related genes in lung adenocarcinoma: Insights into tumor microenvironment and clinical prognosis Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Pengpeng Zhang, Xinyi Wu, Dingli Wang, Mengzhe Zhang, Bin Zhang, Zhenfa Zhang
BackgroundThe hypothesized link between low‐density lipoprotein (LDL) and oncogenesis has garnered significant interest, yet its explicit impact on lung adenocarcinoma (LUAD) remains to be elucidated. This investigation aims to demystify the function of LDL‐related genes (LRGs) within LUAD, endeavoring to shed light on the complex interplay between LDL and carcinogenesis.MethodsLeveraging single‐cell
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Exploring the impact of ITGB2 on glioma progression and treatment: Insights from non‐apoptotic cell death and immunotherapy Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Junhong Zhuang, Changfeng Miao, Chao Liu, Biying Zeng, Linwang Hu, Jun Peng, Ying Xia, Zigui Chen
In the realm of glioma treatment, our groundbreaking research has uncovered the pivotal role of Integrin Beta 2 (ITGB2) in non‐apoptotic cell death and its profound implications for immunotherapy efficacy. Gliomas, known for their aggressive and infiltrative nature, demand innovative therapeutic strategies for improved patient outcomes. Our study bridges a critical gap by examining the interplay between
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Integrated analysis of gut microbiota and metabolomic profiling in colorectal cancer metastasis Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-14 Yang Xia, Ling Duan, Xin‐lian Zhang, Yu‐juan Niu, Xiaoling Ling
Colorectal cancer (CRC) is characterized by its heterogeneity and complex metastatic mechanisms, presenting significant challenges in treatment and prognosis. This study aimed to unravel the intricate interplay between the gut microbiota and metabolic alterations associated with CRC metastasis. By employing high‐throughput sequencing and advanced metabolomic techniques, we identified distinct patterns
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Refining molecular subtypes and risk stratification of ovarian cancer through multi‐omics consensus portfolio and machine learning Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-14 Jing Zhang, Shanshan He, Hongjun Ying
Ovarian cancer (OC), known for its pronounced heterogeneity, has long evaded a unified classification system despite extensive research efforts. This study integrated five distinct multi‐omics datasets from eight multicentric cohorts, applying a combination of ten clustering algorithms and ninety‐nine machine learning models. This methodology has enabled us to refine the molecular subtyping of OC,
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MiR‐2110 induced by chemically synthesized cinobufagin functions as a tumor‐metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-13 Shiyi Fang, Lanzhu Peng, Mengmin Zhang, Rentao Hou, Xing Deng, Xiaoning Li, Jianyang Xin, Lingrong Peng, Zhihua Liu, Yiyi Liu, Yingying Xie, Beixian Zhou, Weiyi Fang, Zhen Liu, Chao Cheng
Tumor cell metastasis is the key cause of death in patients with nasopharyngeal carcinoma (NPC). MiR‐2110 was cloned and identified in Epstein–Barr virus (EBV)‐positive NPC, but its role is unclear in NPC. In this study, we investigated the effect of miR‐2110 on NPC metastasis and its related molecular basis. In addition, we also explored whether miR‐2110 can be regulated by cinobufotalin (CB) and
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Lysine specific demethylase 1 inhibits sodium arsenite activation of HSCs by regulating SESN2/AMPK/ULK1 signaling pathway activity Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-13 Yingwan Zhang, Tian Tian, Cai Liang, Junli Wang, Jiayuan Zhang, Shanshan Tian, Rujia Xie, Ting Yang, Bing Han
Lysine specific demethylase 1 (LSD1) is a histone demethylase that specifically catalyzes the demethylation of histone H3K4 (H3K4me1/2) and regulates gene expression. In addition, it can mediate the process of autophagy through its demethylase activity. Sestrin2 (SESN2) is a stress‐induced protein and a positive regulator of autophagy. In NaAsO2‐induced mouse fibrotic livers and activated hepatic stellate
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Exploration of immune cell heterogeneity by single‐cell RNA sequencing and identification of secretory leukocyte protease inhibitor as an oncogene in pancreatic cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-13 Bolun Ai, Yicheng Liang, Tao Yan, Yangyang Lei
Clinical outcomes remain unsatisfactory in patients with pancreatic cancer (PAC). In this study, through single‐cell sequencing, we identified eight cell subpopulations in the tumor microenvironment (TME). Redimensional clustering of epithelial cells, myeloid cells, and cancer‐associated fibroblasts (CAFs) revealed heterogeneity in the TME of PAC. Intercellular communication analysis showed strong
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Prediction of potential targets and toxicological insights of Astragalus in liver cancer based on network pharmacology: Integrating systems biology, drug interaction networks, and toxicological perspectives Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-13 Minjun Zou, Zhiye Zheng, Zhikai Xiahou, Jianwei Cao
This study investigates Astragalus's efficacy as a novel therapeutic option for primary liver cancer (PLC), capitalizing on its anti‐inflammatory and antiviral effects. We utilized network pharmacology to unveil Astragalus's potential targets against PLC, revealing significant gene expression alterations in treated samples—20 genes were up‐regulated, and 20 were down‐regulated compared to controls
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MiR‐375 impairs breast cancer cell stemness by targeting the KLF5/G6PD signaling axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-12 Haitao Chen, Shanshan Hou, Hongwei Zhang, Bing Zhou, Huifang Xi, Xiaofang Li, Zheng Lufeng, Qianqian Guo
Recurrence of breast cancer may be due to the presence of breast cancer stem cells (BCSC). Abnormal tumor cell growth is closely associated with increased reactive oxygen species (ROS) and disruption of redox homeostasis, and BCSCs exhibit low levels of ROS. The detailed mechanism between the low levels of ROS in BCSCs and their maintenance of stemness characteristics has not been reported. A growing
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Protective effect of crocin on peroxidation‐induced oxidative stress and apoptosis in IPEC‐J2 cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-12 Jing Wang, Hongbing Song, Yongjie Huang, Chu Yang, Yanling Wu, Ruiyi Lin, Tianfang Xiao, Weimin Lin
The antioxidant properties of crocin are attracting interest, yet the underlying mechanisms by which crocin mitigates oxidative stress‐induced intestinal damage have not been determined. This study aimed to elucidate the effects of crocin on oxidative stress, apoptosis, and intestinal epithelial injury in intestinal epithelial cells (IPEC‐J2). Using an H2O2‐induced oxidative stress model in IPEC‐J2
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In silico investigation of the role of miRNAs in a possible developmental origin of prostate cancer in F1 and F2 offspring of mothers exposed to a phthalate mixture Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-11 A. M. Aquino, M. N. Fioretto, L. G. Alonso‐Costa, V. A. Rocha, P. V. Souza, N. Magosso, L. F. Barbisan, L. A. Justulin, J. A. Flaws, W. R. Scarano
A previous study using miRNA sequencing revealed that exposure to a mixture of phthalates during pregnancy and lactation dysregulated rno‐miR‐184 and rno‐miR‐141‐3p in the ventral prostate (VP) of offspring. Here, rno‐miR‐184 and rno‐miR‐141‐3 expressions were obtained by RT‐qPCR in the VP of F1 males as well as in F2 offspring, aiming to establish a relationship with possible oncogenic targets through
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Identifying immune‐related prognostic biomarkers in osteosarcoma: Development and validation of the tumor immune microenvironment risk model based on analysis of TCGA Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-11 Xiao Zhang, Yizhe Fan, Zhongyuan Shen, Zhiyu Chen, Wulin You
ObjectiveOsteosarcoma is a rare and aggressive malignancy with limited effective therapeutic options. This study aimed to identify immune‐related prognostic biomarkers and develop a prognostic model for osteosarcoma.MethodsWe performed integrated analysis of transcriptomic data and immune cell infiltration profiles of 84 osteosarcoma samples from the Cancer Genome Atlas (TCGA) database. Time‐dependent
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Navigating colorectal cancer prognosis: A Treg‐related signature discovered through single‐cell and bulk transcriptomic approaches Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-09 Xuening Lv, Wen Ma, Xiaye Miao, Shaohui Hu, Huaibing Xie
BackgroundThe significance of regulatory T cells (Tregs) in colorectal cancer is unclear.MethodsThe single‐cell sequencing data for colorectal cancer, specifically GSE132465 and GSE188711, were retrieved from the GEO database. Simultaneously, bulk transcriptome data were obtained from the UCSC Xena website. To delve into the heterogeneity of Treg cells and identify key genes at the single‐cell sequencing
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Bisphenol A promotes cell death in healthy respiratory system cells through inhibition of cell proliferation and induction of G2/M cell cycle arrest Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-09 Ferhunde Aysin
Bisphenol A (BPA) is a substance that can harm the environment and human health by interfering with the normal functioning of the body's hormonal system. It is commonly found in various plastic‐based products such as cosmetics, canned foods, beverage containers, and medical equipment and as well as it can also be absorbed by inhalation. There have been limited studies on the effects of BPA on lung
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Qi‐dan‐dihuang decoction ameliorates renal fibrosis in diabetic rats via p38MAPK/AKT/mTOR signaling pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-08 Liuyan Kuang, Yanting You, Jieying Qi, Jieyu Chen, Xinghong Zhou, Shuai Ji, Jingru Cheng, Hiu Yee Kwan, Pingping Jiang, Xiaomin Sun, Mengting Su, Ming Wang, Wenxiao Chen, Ren Luo, Xiaoshan Zhao, Lin Zhou
ContextQi‐dan‐dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood.ObjectiveThis study reveals the mechanism by which QDD ameliorates DKD.Materials and MethodsThe compounds in QDD were identified by high‐performance liquid chromatography and quadrupole‐time‐of‐flight tandem mass spectrometry (HPLC‐Q‐TOF‐MS). Key targets and
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Anti‐pollutant effect of oleic acid against urban particulate matter is mediated via regulation of AhR‐ and TRPV1‐mediated signaling in vitro Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-08 Seoyoung Choi, Seyoung Yang, Ji Woong Kim, Kitae Kwon, Sae Woong Oh, Eunbi Yu, Su Bin Han, Soo Hyun Kang, Jung Hyun Lee, Heejun Ha, Jeong Kyun Yoo, Su Young Kim, Young Soo Kim, Jae Youl Cho, Jongsung Lee
Urban Particulate Matter (UPM) induces skin aging and inflammatory responses by regulating skin cells through the transient receptor potential vanilloid 1 (TRPV1). Although oleic acid, an unsaturated free fatty acid (FFA), has some functional activities, its effect on UPM‐induced skin damage has not been elucidated. Here, we investigated signaling pathways on how oleic acid is involved in attenuating
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Exploring the causal link between circulating cytokines and sarcopenia traits: A Mendelian randomization analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-07 Wang Di, Yang Luyao, Yang Chengwei, M. Valtonen Anu, Kulmala Juha‐Pekka, Gao Ying
BackgroundPrevious observational studies have linked circulating cytokines to sarcopenia, but their causal relationship remains unclear. This study employed Mendelian Randomization (MR) to investigate the causal links between circulating cytokines and sarcopenia‐related traits using genetic data.MethodsA two‐sample bidirectional MR analysis was conducted using data from individuals of European ancestry
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Precision unveiled: Synergistic genomic landscapes in breast cancer—Integrating single‐cell analysis and decoding drug toxicity for elite prognostication and tailored therapeutics Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-07 Chenglu Jiang, Shengke Zhang, Lai Jiang, Zipei Chen, Haiqing Chen, Jinbang Huang, Jingyi Tang, Xiufang Luo, Guanhu Yang, Jie Liu, Hao Chi
BackgroundGlobally, breast cancer, with diverse subtypes and prognoses, necessitates tailored therapies for enhanced survival rates. A key focus is glutamine metabolism, governed by select genes. This study explored genes associated with T cells and linked them to glutamine metabolism to construct a prognostic staging index for breast cancer patients for more precise medical treatment.MethodsTwo frameworks
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Triphenyl phosphate interferes with the synthesis of steroid hormones through the PPARγ/CD36 pathway in human trophoblast JEG‐3 cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-07 Yuting Chen, Qian Liu, Yao Wang, Mengzhu Jiang, Jing Zhang, Yuguo Liu, Xiaoxun Lu, Huanwen Tang, Xiaoshan Liu
Triphenyl phosphate (TPhP), a chemical commonly found in human placenta and breast milk, has been shown to disturb the endocrine system. Our previous study confirmed that TPhP could accumulate in the placenta and interference with placental lipid metabolism and steroid hormone synthesis, as well as induce endoplasmic reticulum (ER) stress through PPARγ in human placental trophoblast JEG‐3 cells. However
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Arecoline induces neurotoxicity in HT22 cells via the promotion of endoplasmic reticulum stress and downregulation of the Nrf2/HO‐1 pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-07 He Yan, Jiameng Ding, Xiong Li, Shuyue Li, Dongxian Zhang
Arecoline, the predominant bioactive substance extracted from areca nut (AN), is the world's fourth most frequently used psychoactive material. Research has revealed that chewing AN can affect the central nervous system (CNS) and may lead to neurocognitive deficits that are possibly linked to the action of arecoline. However, the mechanism behind the neurotoxicity caused by arecoline remains unclear
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Association between sarcopenia‐related markers and cholelithiasis: A prospective and Mendelian randomization study Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-07 Pengcheng Ma, Ruining Li, Lin Zeng, Chang Hong, Yan Li, Shengxing Liang, Hongbo Zhu, Hao Cui, Jiaren Wang, Jingzhe He, Zeyang Li, Jun Xu, Li Liu, Lushan Xiao
Cholelithiasis is a common digestive disease that drives a myriad of adverse complications. The correlation between sarcopenia and various digestive disorders has been extensively researched, whereas its association with cholelithiasis remains unreported. We aimed to investigate the association through prospective and Mendelian randomization (MR) analyses and establish a quantitative score reflecting
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Exploring the causal relationship between antihypertensive drugs and glioblastoma by combining drug target Mendelian randomization study, eQTL colocalization, and single‐cell RNA sequencing Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-07 Songyun Zhao, Yi Xie, Xu Ding, Chuanhua Zheng, Jiaxing Chen, Ning Zhao, Yi Ji, Qi Wang, Yuankun Liu, Chao Cheng
Recent reports indicate a potential oncogenic role of antihypertensive drugs in common cancers. However, it remains uncertain whether this phenomenon influences the risk of glioblastoma multiforme (GBM). This study aimed to assess the potential causal effects of blood pressure (BP) and antihypertensive drugs on GBM. Genome‐wide association study (GWAS) summary statistics for systolic blood pressure
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Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL‐xL signaling axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-06 Min‐Yung Kuo, Wen‐Chyi Dai, Jie‐Li Chang, Jo‐Shu Chang, Tse‐Min Lee, Chia‐Che Chang
Melanoma is the most lethal skin malignancy. Fucoxanthin is a marine carotenoid with significant anticancer activities. Intriguingly, Fucoxanthin's impact on human melanoma remains elusive. Signal Transducer and Activator of Transcription 3 (STAT3) represents a promising target in cancer therapy due to its persistent activation in various cancers, including melanoma. Herein, we revealed that Fucoxanthin
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Antrodia cinnamomea prevents ovariectomized‐promoted bone loss by inhibiting osteoclast formation Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-06 Chang Po‐Chun, Hui‐Kan Su, Shan‐Chi Liu, Le Huynh Hoai Thuong, Yang‐Chang Wu, Hsien‐Te Chen, Tung‐Ying Wu, Chih‐Hsin Tang
Osteoporosis is a common bone disease in aging populations, particularly in postmenopausal women. Anti‐resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are linked with a variety of adverse effects. Antrodia cinnamomea extracts (ACE) are highly renowned for their anticancer, antioxidative, and anti‐inflammatory properties. However, whether ACE‐enriched anti‐osteoporosis
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Prognostic and immunological implications of paraptosis‐related genes in lung adenocarcinoma: Comprehensive analysis and functional verification of hub gene Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-06 Ying Zhuo, Yan Song
BackgroundLung adenocarcinoma (LUAD) poses significant clinical challenges due to its inherent heterogeneity and variable response to treatment. Recent research has specifically focused on elucidating the role of Paraptosis‐related genes (PRGs) in the progression of cancer and the prognosis of patients.MethodsWe conducted a comprehensive analysis of the differential expression of PRGs in LUAD. Additionally
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Comprehensive analysis of basement membrane‐related gene based on single‐cell and bulk RNA sequencing data to predict prognosis and evaluate immune characteristics in colorectal cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-06 Jing Han, Qipeng Wang, Shangshang Li, Jie Yang, Zhengcai Qiu, Wei Fu
AimsBasement membrane‐related genes (BMs) participate in regulating cell polarity, invasion, metastasis, and survival across different tumor types. Nevertheless, the specific functions of BMs in colorectal cancer (CRC) remain uncertain.MethodsTo investigate the clinical relevance of BMs in CRC, we retrieved both gene expression and clinical data from The Cancer Genome Atlas (TCGA) datasets for subsequent
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Artemisia argyi extracts overcome lapatinib resistance via enhancing TMPRSS2 activation in HER2‐positive breast cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-06 Chien‐Yi Ho, Cheng‐Yen Wei, Ruo‐Wen Zhao, Yi‐Lun Ye, Hui‐Chi Huang, Jen‐Chih Lee, Fang‐Ju Cheng, Wei‐Chien Huang
Breast cancer stands as the predominant malignancy and primary cause of cancer‐related mortality among females globally. Approximately 25% of breast cancers exhibit HER2 overexpression, imparting a more aggressive tumor phenotype and correlating with poor prognoses. Patients with metastatic breast cancer receiving HER2 tyrosine kinase inhibitors (HER2 TKIs), such as Lapatinib, develop acquired resistance
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Polystyrene microplastic‐induced endoplasmic reticulum stress contributes to growth plate endochondral ossification disorder in young rat Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-05 Qingqing Zhang, Yuanyuan Lang, Xiaomin Tang, Wenshu Cheng, Zugen Cheng, Mohammad Rizwan, Lixin Xie, Yanling Liu, Hengyi Xu, Yang Liu
BackgroundPrevious studies on the effects of microplastics (MPs) on bone in early development are limited. This study aimed to investigate the adverse effects of MPs on bone in young rats and the potential mechanism.MethodsThree‐week‐old female rats were orally administered MPs for 28 days, and endoplasmic reticulum (ER) stress inhibitor salubrinal (SAL) and ER stress agonist tunicamycin (TM) were
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Elucidating the molecular mechanisms of sepsis: Identifying key aging‐related biomarkers and potential therapeutic targets in the treatment of sepsis Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-05 Jie Zhou, Jiao Liu, Chuanwu Zhang, Yihua Zhou, Zemao Zheng, Haoguang Li
BackgroundSepsis remains a crucial global health issue characterized by high mortality rates and a lack of specific treatments. This study aimed to elucidate the molecular mechanisms underlying sepsis and to identify potential therapeutic targets and compounds.MethodsHigh‐throughput sequencing data from the GEO database (GSE26440 as the training set and GSE13904 and GSE32707 as the validation sets)
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Ameliorative effects of zinc and vitamin E against phthalates‐induced reproductive toxicity in male rats Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-05 Ling‐Zi Xia, Li‐Lan Liu, Jun‐Zhe Yue, Zhen‐Yu Lu, Ru‐Ya Deng, Xi He, Can‐Can Li, Burong Hu, Hai‐Tao Gao
ObjectivePhthalates (PEs) could cause reproductive harm to males. A mixture of three widely used PEs (MPEs) was used to investigate the ameliorative effects of zinc (Zn) and vitamin E (VE) against male reproductive toxicity.MethodsFifty male SD rats were randomly divided into five groups (n = 10). Rats in MPEs group were orally treated with 160 mg/kg/d MPEs, while rats in MPEs combined Zn and/or VE
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lncRNA NORAD alleviates dysfunction of renal proximal tubular epithelial cells during the sepsis‐associated acute kidney injury by modulating the miR‐155‐5p‐PDK1 axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-04 Hulin Lu, Yan Chen, Yong Yang, Min Ding, Fengping Qiu
The sepsis‐associated acute kidney injury (Sa‐AKI) is closely related to high mortality rates worldwide. Injury to the renal proximal tubular epithelial cells (RPTECs), caused by pathological conditions, is a major cause of acute kidney injury (AKI). The lncRNA NORAD has been reported to be positively associated with kidney cancers. However, the biological roles and underlying mechanisms of NORAD in
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STAT3 phosphorylation inhibitor Bt354 exhibits anti‐neoplastic activity in glioblastoma multiforme cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-28 Yi‐Chun Chiang, Padhmavathi Selvam, You‐Xuan Liu, Po‐Chang Shih, Nan‐Fu Chen, Hsiao‐Mei Kuo, Hugo You‐Hsien Lin, Zhi‐Hong Wen, Wu‐Fu Chen
The high mortality rate of glioblastoma multiforme (GBM), a lethal primary brain tumor, is attributable to postsurgical recurrence. STAT3, an oncogenic protein, is a signal transducer and transcription activator encourages cancer cell migration and proliferation, which results in resistance to therapy. STAT3 inhibition reduces cancer metastasis and improves patient prognosis. Bt354, a small molecule
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Characterization of m6A RNA methylation mediated immune heterogeneity and functional validation in hepatocellular carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-27 Chongyou Zhang, Yang Huang, Ming Liang, Jinrong Wu, Guangyou Wang
BackgroundN6‐methyladenosine (m6A) mediates RNA modification in various biological processes. It plays a key role in hepatocellular carcinoma (HCC) through regulating methyltransferase. The present study aims to analyze the correlation between the m6A and the immune status of HCC, and to construct an m6A‐related prognostic signature for HCC.MethodsHCC subtypes with different m6A modification activities
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Poly (lactic‐co‐glycolic acid)‐encapsulated Endostar‐loaded calcium phosphate cement as anti‐tumor bone cement for the treatment of bone metastasis in lung cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-24 QingHua Tian, Cong Tian, YingYing Lu, BiCong Yan, Kaixian Zhang, ChunGen Wu
Lung cancer is one of the most common malignant tumors in the world. In approximately 30%–40% of lung cancer patients, bone metastases ensues with osteolytic destruction. Worse still, intractable pain, pathological fracture, and nerve compression caused by bone metastases are currently the bottleneck of research, diagnosis, and treatment of lung cancer. Therefore, the present study aims at investigating
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FGF23 facilitates IL‐1β synthesis in rheumatoid arthritis through activating PI3K, Akt, and NF‐κB pathways Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-21 Sung‐Lin Hu, Louis Anoop Thadevoos, Trung‐Loc Ho, Yen‐You Lin, Hsien‐Te Chen, Chien‐Chung Huang, Chen‐Ming Su, Chih‐Hsin Tang
Rheumatoid arthritis (RA) is a well‐known autoimmune disorder related with joint pain, joint swelling, cartilage and bone degradation as well as deformity. Fibroblast growth factor 23 (FGF23) is an endocrine factor of the FGF family primarily produced by osteocytes and osteoblasts, involves an essential effect in pathogenesis of RA. IL‐1β is a vital proinflammatory factor in the development of RA.
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Deciphering m6A signatures in hepatocellular carcinoma: Single-cell insights, immune landscape, and the protective role of IGFBP3 Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-16 Shujia Chen, Jie Liu, Shuting Zhang, Lili Zhao, Jindong Zhang, Ping Han, Qian Zhang, Yao Liu, Fengmei Wang, Jia Li
RNA m6 methyladenosine (m6A) modifications impact tumor biology and immune processes, particularly in hepatocellular malignant tumors. Using a consensus clustering algorithm on 371 hepatocellular carcinoma (HCC) samples, we identified three m6A-modified subtypes and correlated them with positive tumor microenvironment (TME) markers for distinct immune phenotypes. Stratifying patients based on m6A scores
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Overexpression of YAP confers radioresistance to esophageal cancer by altering the tumor microenvironment Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-20 Guangyue Yao, Mengqing Shao, Yuanliu Nie, Wentao Zhang, Zhe Yang, Qiang Li
This study aimed to investigate the role of yes‐associated protein (YAP) in the radiotherapy sensitivity of esophageal squamous cell carcinoma (ESCC). The clonogenic ability of ESCC cells was reduced after YAP silencing and radiotherapy. Overexpression of YAP promoted cell survival and had a synergistic effect with the hypoxic microenvironment. YAP was found to directly regulate hypoxia‐inducible factor
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Yifei Sanjie formula alleviates lung cancer progression via regulating PRMT6-YBX1-CDC25A axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-15 Jie Tang, Chenyan Yin, Meiyun Chen, Mengjia Dong, Youqi Xu
Lung cancer (LC) is the most prevalent cancer type, with a high mortality rate worldwide. The current treatment options for LC have not been particularly successful in improving patient outcomes. Yifei Sanjie (YFSJ), a well-applicated traditional Chinese medicine formula, is widely used to treat pulmonary diseases, especially LC, yet little is known about its molecular mechanisms. This study was conducted
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Unveiling hormone-stimulated gene mechanisms in prostate cancer: A prognostic model, immune infiltration analysis, and drug sensitivity study Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-15 Zhongru Fan, Qianqian Yu, Junpeng Deng, Ke Wang, Hongqi Yu, Xin Fan, Jianjun Xie
Hormones promote the progression of prostate cancer (PRCA) through the activation of a complex regulatory network. Inhibition of hormones or modulation of specific network nodes alone is insufficient to suppress the entire oncogenic network. Therefore, it is imperative to elucidate the mechanisms underlying the occurrence and development of PRCA in order to identify reliable diagnostic markers and
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Ellagic acid protects against angiotensin II-induced hypertrophic responses through ROS-mediated MAPK pathway in H9c2 cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-15 Ya-Che Lee, Yeong-Chin Jou, Wan-Ching Chou, Kun-Ling Tsai, Cheng-Huang Shen, Shin-Da Lee
The early myocardial response of hypertension is an elevation of angiotensin-II (Ang-II) concentration, leading to heart failure and cardiac hypertrophy. This hypertrophic event of the heart is mediated by the interaction of Ang type 1 receptors (AT-R1), thereby modulating NADPH oxidase activity in cardiomyocytes, which alters redox status in cardiomyocytes. Ellagic acid (EA) has anti-inflammatory
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Nelumbo nucifera leaves extract ameliorated scopolamine-induced cognition impairment via enhanced adult hippocampus neurogenesis Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-14 Yi-Ju Lee, Chang-Mao Lin, Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang, Li-Sung Hsu
In this presentation, we explored the molecular mechanisms of N. nucifera leaf water extracts (NLWEs) and polyphenol extract (NLPE) on scopolamine-induced cell apoptosis and cognition defects. The administration of NLWE and NLPE did not alter the body weight and serum biomarker rs and significantly ameliorated scopolamine-induced cognition impairment according to Y-maze test analysis. In mice, treatment
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Supercritical CO2 fluid extract from Stellariae Radix ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by inhibit M1 macrophages polarization via AMPK activation Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-14 Wei Wu, Le Song, Hong Wang, Lu Feng, Zhenkai Li, Yanqing Li, Le Li, Li Peng
Yin chai hu (Radix Stellariae) is a root medicine that is frequently used in Chinese traditional medicine to treat fever and malnutrition. In modern medicine, it has been discovered to have anti-inflammatory, anti-allergic, and anticancer properties. In a previous study, we were able to extract lipids from Stellariae Radix using supercritical CO2 extraction (SRE), and these sterol lipids accounted
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Development of the ARDS-derived gene panel for lung adenocarcinoma prognosis stratification and experiment validation of CCL20 expression Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-14 Jingjing Fang, Chaolu Shi, Qin Huang, Lei Huang, Xinnian Wang, Biqing Yan
Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by lung inflammation and high mortality rates. Lung cancer, specifically lung adenocarcinoma (LUAD), is a major cause of cancer-related deaths worldwide. Patients with LUAD, particularly those undergoing chemotherapy, are more likely to develop ARDS. ARDS inflicts major malfunctioning in the immune system. We suspected
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Combination of Polygonatum Rhizoma and Scutellaria baicalensis triggers apoptosis through downregulation of PON3-induced mitochondrial damage and endoplasmic reticulum stress in A549 cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-13 Haitao Liu, Liduo Yue, Yubin Li, Tiansheng Zheng, Wenjia Zhang, Chaoqun Li, Wenbin Zhuang, Lihong Fan
Scutellaria baicalensis (SB) and Polygonatum Rhizoma (PR), two traditional Chinese medicines, are both known to suppress cancer. However, the mechanism and effect of combined treatment of them for lung cancer are rarely known. Investigating the combined effect of SB and PR (hereafter referred to as SP) in potential mechanism of lung cancer is required. This study was to evaluate the inhibitory effects
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LINC01572 promotes triple-negative breast cancer progression through EIF4A3-mediated β-catenin mRNA nuclear exportation Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-05 Bowen Zheng, Baian Zhou, Danrong Ye, Yuying Wang, Wenfang Zheng, Xuehui Wang, Diya Liu, Fengyuan Qian, Xiqian Zhou, Tao Yan, Yating Li, Lin Fang
Long noncoding RNAs have been reported to be involved in the development of breast cancer. LINC01572 was previously reported to promote the development of various tumors. However, the potential biological function of LINC01572 in breast cancer remains largely unknown. R language was used to perform bioinformatic analysis of The Cancer Genome Atlas data. The expression level of RNAs was examined by
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An analysis of the prognostic role of reactive oxygen species-associated genes in breast cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-06 Yangyan Zhong, Hong Cao, Wei Li, Jian Deng, Dan Li, Junjie Deng
This study aimed to type breast cancer in relation to reactive oxygen species (ROS), clinical indicators, single nucleotide variant (SNV) mutations, functional differences, immune infiltration, and predictive responses to immunotherapy or chemotherapy, and constructing a prognostic model.
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Similar toxicity potential of glyphosate and glyphosate-based herbicide on cerebellar development after maternal exposure in rats Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-05 Ryota Ojiro, Shunsuke Ozawa, Xinyu Zou, Qian Tang, Gye-Hyeong Woo, Makoto Shibutani
Studies on the effects of glyphosate (GlyP) and glyphosate-based herbicides (GBHs) on cerebellar development are extremely limited. This study examined the effects of maternal exposure to GlyP and GBH on rat cerebellar development in male offspring. From day 6 of gestation until day 21 postpartum at weaning, dams were given GlyP at 1.5% or 3.0% in diet or GBH at 1.0% in drinking water (corresponding
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Circ_0000877 accelerates proliferation and immune escape of non-small cell lung cancer cells by regulating microRNA-637/E2F2 axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-05 Ting'an Chen, Zhengdong Li, Junzhu Chen, Zhe Xu
Recently, circular RNA (circRNA) has become a vital targeted therapy gene for non-small-cell lung cancer (NSCLC) cells. CircRNA_0000877 (Circ_0000877) has been researched in diffuse large B-cell lymphoma (DLBCL). However, whether circ_0000877 regulated NSCLC cell progression is still poorly investigated. The research attempted to investigate the influence of circ_0000877 in NSCLC.
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Baicalein targets STMN1 to inhibit the progression of nasopharyngeal carcinoma via regulating the Wnt/β-catenin pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-05 Zheng Li, Xiaohang Cai
Nasopharyngeal carcinoma is a common malignancy in the head and neck. Baicalein has been reported to exert the anticancer effects on various cancers. In this study, our aim was to explore the function of baicalein in the development of nasopharyngeal carcinoma and further investigate the potential underlying mechanisms.
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Fludioxonil induces cardiotoxicity via mitochondrial dysfunction and oxidative stress in two cardiomyocyte models Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-05 Su-Min Seong, Ryeo-Eun Go, Hong Kyu Lee, Kyung-Chul Choi
Fludioxonil (Flu) is a phenylpyrrole fungicide and is currently used in over 900 agricultural products globally. Flu possesses endocrine-disrupting chemical-like properties and has been shown to mediate various physiological and pathological changes, such as apoptosis and differentiation, in diverse cell lines. However, the effects of Flu on cardiomyocytes have not been studied so far. The present
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Cyclizine induces cytotoxicity and apoptosis in macrophages through the extrinsic and intrinsic apoptotic pathways Environ. Toxicol. (IF 4.5) Pub Date : 2024-02-05 Yin-Che Lu, Chen-Yu Chiang, Yu-Wei Hsu, Chun-Jung Chen, Wen-Ying Chen, Ching-Chi Tseng, Lie-Hua Deng, Shih-Pin Chen, Yu-Hsiang Kuan
Cyclizine, an over-the-counter and prescription antihistamine, finds widespread application in the prevention and treatment of motion sickness, encompassing symptoms such as nausea, vomiting, dizziness, along with its effectiveness in managing vertigo. However, the overuse or misuse of cyclizine may lead to hallucinations, confusion, tachycardia, and hypertension. The molecular mechanisms underlying