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Validation of CDC45 as a novel biomarker for diagnosis and prognosis of gastric cancer PeerJ (IF 2.7) Pub Date : 2024-03-18
Background Cell division cycle protein 45 (CDC45) has been demonstrated to play vital roles in the progression of various malignancies. However, the clinical significance of CDC45 in gastric cancer (GC) remains unreported. Method In this study, we employed the TCGA database and the TCGA & GTEx dataset to compare the mRNA expression levels of CDC45 between gastric cancer tissues and adjacent or normal
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Deciphering the genomes of motility-deficient mutants of Vibrio alginolyticus 138-2 PeerJ (IF 2.7) Pub Date : 2024-03-18 Kazuma Uesaka, Keita Inaba, Noriko Nishioka, Seiji Kojima, Michio Homma, Kunio Ihara
The motility of Vibrio species plays a pivotal role in their survival and adaptation to diverse environments and is intricately associated with pathogenicity in both humans and aquatic animals. Numerous mutant strains of Vibrio alginolyticus have been generated using UV or EMS mutagenesis to probe flagellar motility using molecular genetic approaches. Identifying these mutations promises to yield valuable
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Changes in hamstring contractile properties during the competitive season in young football players PeerJ (IF 2.7) Pub Date : 2024-03-18 Paweł Pakosz, Mariusz Konieczny, Przemysław Domaszewski, Tomasz Dybek, Mariusz Gnoiński, Elżbieta Skorupska
Background The study aimed to examine alterations and imbalances in hamstring muscle contractile properties among young football players throughout their competitive season, and to understand how these changes might contribute to the risk of muscle injuries. Hamstring injuries are particularly common in football, yet the underlying causes and effective prevention methods remain unclear. Methods The
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Integrating single-cell and bulk sequencing data to identify glycosylation-based genes in non-alcoholic fatty liver disease-associated hepatocellular carcinoma PeerJ (IF 2.7) Pub Date : 2024-03-18 Zhijia Zhou, Yanan Gao, Longxin Deng, Xiaole Lu, Yancheng Lai, Jieke Wu, Shaodong Chen, Chengzhong Li, Huiqing Liang
Background The incidence of non-alcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) has been increasing. However, the role of glycosylation, an important modification that alters cellular differentiation and immune regulation, in the progression of NAFLD to HCC is rare. Methods We used the NAFLD-HCC single-cell dataset to identify variation in the expression of glycosylation
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Anti-ENO1 antibody combined with metformin against tumor resistance: a novel antibody-based platform PeerJ (IF 2.7) Pub Date : 2024-03-18 Xiong Shu, Hui Wen Zhang, Shi Ya Liu, Li Xin Sun, Tao Zhang, Yu Liang Ran
Background Antibody-based platforms (i.e., ADC) have emerged as one of the most encouraging tools for the cancer resistance caused by cancer stem cells (CSCs) enrichment. Our study might provide a promising therapeutic direction against drug resistance and serve as a potential precursor platform for screening ADC. Methods The cell migration, invasion, drug resistance, and self-renewal were assessed
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Biochar’s role in improving pakchoi quality and microbial community structure in rhizosphere soil PeerJ (IF 2.7) Pub Date : 2024-03-18 Xia Wu, Fengjun Yang, Jili Zhang, Feng Gao, Yi Chen Hu, Kejun Yang, Peng Wang
Background Biochar amendments enhance crop productivity and improve agricultural quality. To date, studies on the correlation between different amounts of biochar in pakchoi (Brassica campestris L.) quality and rhizosphere soil microorganisms are limited, especially in weakly alkaline soils. The experiment was set up to explore the effect of different concentrations of biochar on vegetable quality
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The role of temperature on the development of circadian rhythms in honey bee workers PeerJ (IF 2.7) Pub Date : 2024-03-15 Manuel A. Giannoni-Guzmán, Eddie Perez Claudio, Janpierre Aleman-Rios, Gabriel Diaz Hernandez, Melina Perez Torres, Alexander Melendez Moreno, Darimar Loubriel, Darrell Moore, Tugrul Giray, Jose L. Agosto-Rivera
Circadian rhythms in honey bees are involved in various processes that impact colony survival. For example, young nurses take care of the brood constantly throughout the day and lack circadian rhythms. At the same time, foragers use the circadian clock to remember and predict food availability in subsequent days. Previous studies exploring the ontogeny of circadian rhythms of workers showed that the
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Epidemiology and classification for canine and feline mammary gland tumors: a histopathological survey of 437 mammary gland tumor biopsies performed in a secondary care hospital in Chiang Mai, Thailand from 2012 to 2019 PeerJ (IF 2.7) Pub Date : 2024-03-15 Wanwisa Srisawat, Kidsadagon Pringproa, Worapat Prachasilchai, Atigan Thongtharb, Nattawooti Sthitmatee
Background Metastatic disease resulting from mammary gland tumors (MGTs) is a known cause of death among dogs and cats. Keys to successful prevention and management strategies involve the accurate recording of diagnostic data. Methods This retrospective study reviewed the epidemiology and classification of canine mammary gland tumors (CMTs) and feline mammary gland tumors (FMTs), as well as the factors
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Exploring the antioxidant potential of chalcogen-indolizines throughout in vitro assays PeerJ (IF 2.7) Pub Date : 2024-03-15 Cleisson Schossler Garcia, Marcia Juciele da Rocha, Marcelo Heinemann Presa, Camila Simões Pires, Evelyn Mianes Besckow, Filipe Penteado, Caroline Signorini Gomes, Eder João Lenardão, Cristiani Folharini Bortolatto, César Augusto Brüning
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are highly reactive molecules produced naturally by the body and by external factors. When these species are generated in excessive amounts, they can lead to oxidative stress, which in turn can cause cellular and tissue damage. This damage is known to contribute to the aging process and is associated with age-related conditions, including
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Resting heart rate and risk of dementia: a Mendelian randomization study in the international genomics of Alzheimer’s Project and UK Biobank PeerJ (IF 2.7) Pub Date : 2024-03-15 Xingxing Chen, Yi Zheng, Jun Wang, Blake Yue, Xian Zhang, Kenta Nakai, Lijing L. Yan
Background Observational studies have demonstrated that a higher resting heart rate (RHR) is associated with an increased risk of dementia. However, it is not clear whether the association is causal. This study aimed to determine the causal effects of higher genetically predicted RHR on the risk of dementia. Methods We performed a two-sample Mendelian randomization analysis to investigate the causal
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The influence of stand composition and season on canopy structure and understory light environment in different subtropical montane Pinus massoniana forests PeerJ (IF 2.7) Pub Date : 2024-03-15 Peng Jin, Ming Xu, Qiupu Yang, Jian Zhang
Canopy structure and understory light have important effects on forest productivity and the growth and distribution of the understory. However, the effects of stand composition and season on canopy structure and understory light environment (ULE) in the subtropical mountain Pinus massoniana forest system are poorly understood. In this study, the natural secondary P. massoniana—Castanopsis eyrei mixed
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Characterization of social frailty domains and related adverse health outcomes in the Asia-Pacific: a systematic literature review PeerJ (IF 2.7) Pub Date : 2024-03-15 Tengku Aizan Hamid, Sarah Abdulkareem Salih, Siti Farra Zillah Abdullah, Rahimah Ibrahim, Aidalina Mahmud
Background Frailty is a significant healthcare challenge worldwide, increasing interest in developing more assessment tools covering for frailty. Recently, there has been a growing awareness of a correlation between social variables and frailty in older people. However, there is a lack of understanding of the social domains of frailty and the related adverse outcomes, particularly in the Asia-Pacific
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Comparing the effects of empagliflozin and liraglutide on lipid metabolism and intestinal microflora in diabetic mice PeerJ (IF 2.7) Pub Date : 2024-03-15 Qiong Yang, Ling Deng, Changmei Feng, Jianghua Wen
Background and Objectives Recent studies have shown that the imbalance of intestinal flora is related to the occurrence and progression of diabetic nephropathy (DN) and can affect lipid metabolism. Sodium-dependent glucose transporters 2 (SGLT2) inhibitor and glucagon-like peptide-1 (GLP-1) receptor agonist are commonly used hypoglycemic drugs and have excellent renal safety. The purpose of this study
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Conspecific and heterospecific cueing in shelter choices of Blaptica dubia cockroaches PeerJ (IF 2.7) Pub Date : 2024-03-15 Todd M. Freeberg, S. Ryan Risner, Sarah Y. Lang, Sylvain Fiset
Background Like many cockroaches, Argentinian wood roaches, Blaptica dubia, prefer darker shelters over lighter shelters. In three experiments, we asked whether chemical cues from other roaches might influence shelter choice, a process known as conspecific or heterospecific cueing, depending on whether the cues come from an individual of the same or a different species, respectively. Methods Each experiment
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Clinical significance of small nuclear ribonucleoprotein U1 subunit 70 in patients with hepatocellular carcinoma PeerJ (IF 2.7) Pub Date : 2024-03-15 Dong Jiang, Xia-Ling Zhu, Yan An, Yi-ran Li
Background & Aims Small nuclear ribonucleoprotein U1 subunit 70 (SNRNP70) as one of the components of the U1 small nuclear ribonucleoprotein (snRNP) is rarely reported in cancers. This study aims to estimate the application potential of SNRNP70 in hepatocellular carcinoma (HCC) clinical practice. Methods Based on the TCGA database and cohort of HCC patients, we investigated the expression patterns
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Mammal dung–dung beetle trophic networks: an improved method based on gut-content DNA PeerJ (IF 2.7) Pub Date : 2024-03-15 Karen M. Pedersen, Christoph von Beeren, Arianna Oggioni, Nico Blüthgen
Background Dung beetles provide many important ecosystem services, including dung decomposition, pathogen control, soil aeration, and secondary seed dispersal. Yet, the biology of most dung beetles remains unknown. Natural diets are poorly studied, partly because previous research has focused on choice or attraction experiments using few, easily accessible dung types from zoo animals, farm animals
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Construction of a predictive model for bone metastasis from first primary lung adenocarcinoma within 3 cm based on machine learning algorithm: a retrospective study PeerJ (IF 2.7) Pub Date : 2024-03-14 Yu Zhang, Lixia Xiao, Lan LYu, Liwei Zhang
Background Adenocarcinoma, the most prevalent histological subtype of non-small cell lung cancer, is associated with a significantly higher likelihood of bone metastasis compared to other subtypes. The presence of bone metastasis has a profound adverse impact on patient prognosis. However, to date, there is a lack of accurate bone metastasis prediction models. As a result, this study aims to employ
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Generation and characterization of mAb 61H9 against junctional adhesion molecule-a with potent antitumor activity PeerJ (IF 2.7) Pub Date : 2024-03-14 Kang Liu, Hang Yang, Rong Xiong, Yunlong Shen, Guiqin Song, Jinliang Yang, Zhenling Wang
Junctional adhesion molecule-A (JAM-A) is an adhesion molecule that exists on the surface of certain types of cells, including white blood cells, endothelial cells, and dendritic cells. In this study, the cDNA sequences of JAM-A-Fc were chemically synthesized with optimization for mammalian expression. Afterward, we analyzed JAM-A protein expression through transient transfection in HEK293 cell lines
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Plant growth regulators mitigate oxidative damage to rice seedling roots by NaCl stress PeerJ (IF 2.7) Pub Date : 2024-03-14 Yaxin Wang, Li-ming Zhao, Naijie Feng, Dianfeng Zheng, Xue Feng Shen, Hang Zhou, Wenxin Jiang, Youwei Du, Huimin Zhao, Xutong Lu, Peng Deng
The aim of this experiment was to investigate the effects of exogenous sprays of 5-aminolevulinic acid (5-ALA) and 2-Diethylaminoethyl hexanoate (DTA-6) on the growth and salt tolerance of rice (Oryza sativa L.) seedlings. This study was conducted in a solar greenhouse at Guangdong Ocean University, where ‘Huanghuazhan’ was selected as the test material, and 40 mg/L 5-ALA and 30 mg/L DTA-6 were applied
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The impact of sprint interval training versus moderate intensity continuous training on blood pressure and cardiorespiratory health in adults: a systematic review and meta-analysis PeerJ (IF 2.7) Pub Date : 2024-03-14 Weibao Liang, Chuannan Liu, Xujie Yan, Yu Hou, Guan Yang, Jianmin Dai, Songtao Wang
Background Although aerobic exercise is the primary modality recommended for the treatment of hypertension, it remains unclear whether high-intensity all-out sprint interval training (SIT) can result in greater reductions of blood pressure (BP) and cardiorespiratory health. This systematic review aims to compare the impact of SIT versus Moderate-intensity continuous training (MICT) on improvements
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Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells PeerJ (IF 2.7) Pub Date : 2024-03-14 Leanna Rinehart, Wendy E. Stewart, Natalie Luffman, Matthew Wawersik, Oliver Kerscher
Stem cells are critical for replenishment of cells lost to death, damage or differentiation. Drosophila testes are a key model system for elucidating mechanisms regulating stem cell maintenance and differentiation. An intriguing gene identified through such studies is the transcription factor, chronologically inappropriate morphogenesis (Chinmo). Chinmo is a downstream effector of the Jak-STAT signaling
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On population structure and breeding biology of burrowing crab Dotilla blanfordi Alcock, 1900 PeerJ (IF 2.7) Pub Date : 2024-03-13 Krupal Patel, Heris Patel, Daoud Ali, Swapnil Gosavi, Nisha Choudhary, Virendra Kumar Yadav, Kauresh Vachhrajani, Ashish Patel, Dipak Kumar Sahoo, Jigneshkumar Trivedi
Background The present study investigated the population structure and breeding biology of the burrowing brachyuran crab species Dotilla blanfordi Alcock, 1900, which is commonly found on the sandy beach of Bhavnagar, located on the Gulf of Kachchh, Gujarat coast, India. Methods Monthly sampling was conducted from February 2021 to January 2022 at the time of low tide using three line transects perpendicular
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Gut microbiota and its metabolites in Alzheimer’s disease: from pathogenesis to treatment PeerJ (IF 2.7) Pub Date : 2024-03-13 Xinfu Zou, Guoqiang Zou, Xinyan Zou, Kangfeng Wang, Zetao Chen
Introduction An increasing number of studies have demonstrated that altered microbial diversity and function (such as metabolites), or ecological disorders, regulate bowel–brain axis involvement in the pathophysiologic processes in Alzheimer’s disease (AD). The dysregulation of microbes and their metabolites can be a double-edged sword in AD, presenting the possibility of microbiome-based treatment
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EPI-SF: essential protein identification in protein interaction networks using sequence features PeerJ (IF 2.7) Pub Date : 2024-03-13 Sovan Saha, Piyali Chatterjee, Subhadip Basu, Mita Nasipuri
Proteins are considered indispensable for facilitating an organism’s viability, reproductive capabilities, and other fundamental physiological functions. Conventional biological assays are characterized by prolonged duration, extensive labor requirements, and financial expenses in order to identify essential proteins. Therefore, it is widely accepted that employing computational methods is the most
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Land potential assessment and trend-analysis using 2000–2021 FAPAR monthly time-series at 250 m spatial resolution PeerJ (IF 2.7) Pub Date : 2024-03-13
The article presents results of using remote sensing images and machine learning to map and assess land potential based on time-series of potential Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) composites. Land potential here refers to the potential vegetation productivity in the hypothetical absence of short–term anthropogenic influence, such as intensive agriculture and urbanization
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Filling the gaps in ecology of tropical tiger beetles (Coleoptera: Cicindelidae): first quantitative data of sexual dimorphism in semi-arboreal Therates from the Philippine biodiversity hotspot PeerJ (IF 2.7) Pub Date : 2024-03-13 Dale Ann Acal, Anna Sulikowska-Drozd, Radomir Jaskuła
Background Sexual dimorphism, driven by sexual selection, leads to varied morphological distinctions in male and female insects, providing insights into selection pressures across species. However, research on the morphometric variability within specific taxa of tiger beetles (Coleoptera: Cicindelidae), particularly arboreal and semi-arboreal species, remains very limited. Methods We investigate sexual
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Evaluation of different Kabuli chickpea genotypes against Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) in relation to biotic and abiotic factors PeerJ (IF 2.7) Pub Date : 2024-03-13 Hafiz Muhammad Bilal Yousuf, Muhammad Yasin, Habib Ali, Khalid Naveed, Ammara Riaz, Amal Mohamed AlGarawi, Ashraf Atef Hatamleh, Yunfeng Shan
Background The chickpea pod borer Helicoverpa armigera (Hübner) is a significant insect pest of chickpea crops, causing substantial global losses. Methods Field experiments were conducted in Central Punjab, Pakistan, to investigate the impact of biotic and abiotic factors on pod borer population dynamics and infestation in nine kabuli chickpea genotypes during two cropping seasons (2020–2021 and 2021–2022)
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Impact of the coronavirus disease 2019 pandemic on the diversity of notifiable infectious diseases: a case study in Shanghai, China PeerJ (IF 2.7) Pub Date : 2024-03-12 Yongfang Zhang, Wenli Feng
The outbreak of coronavirus disease 2019 (COVID-19) has not only posed significant challenges to public health but has also impacted every aspect of society and the environment. In this study, we propose an index of notifiable disease outbreaks (NDOI) to assess the impact of COVID-19 on other notifiable diseases in Shanghai, China. Additionally, we identify the critical factors influencing these diseases
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First evidence of sexual dimorphism in olfactory organs of deep-sea lanternfishes (Myctophidae) PeerJ (IF 2.7) Pub Date : 2024-03-12 Rene P. Martin, W. Leo Smith
Finding a mate is of the utmost importance for organisms, and the traits associated with successfully finding one can be under strong selective pressures. In habitats where biomass and population density is often low, like the enormous open spaces of the deep sea, animals have evolved many adaptations for finding mates. One convergent adaptation seen in many deep-sea fishes is sexual dimorphism in
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Academic stress in college students: descriptive analyses and scoring of the SISCO-II inventory PeerJ (IF 2.7) Pub Date : 2024-03-12 Juan-Luis Castillo-Navarrete, Claudio Bustos, Alejandra Guzman-Castillo, Walter Zavala
In a competitive and demanding world, academic stress is of increasing concern to students. This systemic, adaptive, and psychological process is composed of stressful stimuli, imbalance symptoms, and coping strategies. The SISCO-II Academic Stress Inventory (SISCO-II-AS) is a psychometric instrument validated in Chile. It evaluates stressors, symptoms, and coping, both individually and globally. For
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Construction and validation of a nomogram model to predict the poor prognosis in patients with pulmonary cryptococcosis PeerJ (IF 2.7) Pub Date : 2024-03-11 Xiaoli Tan, Yingqing Zhang, Jianying Zhou, Wenyu Chen, Hua Zhou
Background Patients with poor prognosis of pulmonary cryptococcosis (PC) are prone to other complications such as meningeal infection, recurrence or even death. Therefore, this study aims to analyze the influencing factors in the poor prognosis of patients with PC, so as to build a predictive nomograph model of poor prognosis of PC, and verify the predictive performance of the model. Methods This retrospective
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Effect of exercise based interventions on sleep and circadian rhythm in cancer survivors—a systematic review and meta-analysis PeerJ (IF 2.7) Pub Date : 2024-03-08 Rachita Gururaj, Stephen Rajan Samuel, K Vijaya Kumar, Ravishankar Nagaraja, Justin W.L. Keogh
Background Disrupted circadian rhythm commonly reported in cancer survivors is closely associated with cancer related fatigue, sleep disturbances and compromised quality of life. As more cancer survivors request non-pharmacological treatment strategies for the management of their chronic sleep-related symptoms, there is a need for meta-analyses of various interventions such as exercise on sleep and
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Accelerometry-assessed daily physical activity and compliance with recommendations in Spanish children: importance of physical education classes and vigorous intensity PeerJ (IF 2.7) Pub Date : 2024-03-08 Juan Carlos Benavente-Marín, Francisco Javier Barón-López, Begoña Gil Barcenilla, Guadalupe Longo Abril, José M. Rumbao Aguirre, Napoleón Pérez-Farinós, Julia Wärnberg
Background Physical activity (PA) is associated with numerous health benefits. Vigorous PA (VPA) may have a greater impact on public health than lower-intensity PA. The incorporation of a specific recommendation on VPA could complement and improve existing recommendations for average daily moderate-vigorous PA (MVPA). Physical education classes could have a positive impact on children’s adherence to
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Reliability and validity of an app-assisted tissue compliance meter in measuring tissue stiffness on a phantom model PeerJ (IF 2.7) Pub Date : 2024-03-07
Background Most methods for soft tissue stiffness assessment require high financial resources, significant technical effort, or extensive therapist training. The PACT Sense device was developed to be used in a wide range of applications and user groups. However, to date, there are no data on its validity and reliability. The aim of this study was to investigate the validity and reliability of the PACT
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High-resolution density assessment assisted by deep learning of Dendrophyllia cornigera (Lamarck, 1816) and Phakellia ventilabrum (Linnaeus, 1767) in rocky circalittoral shelf of Bay of Biscay PeerJ (IF 2.7) Pub Date : 2024-03-07 Alberto Gayá-Vilar, Adolfo Cobo, Alberto Abad-Uribarren, Augusto Rodríguez, Sergio Sierra, Sabrina Clemente, Elena Prado
This study presents a novel approach to high-resolution density distribution mapping of two key species of the 1170 “Reefs” habitat, Dendrophyllia cornigera and Phakellia ventilabrum, in the Bay of Biscay using deep learning models. The main objective of this study was to establish a pipeline based on deep learning models to extract species density data from raw images obtained by a remotely operated
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Research overview on the genetic mechanism underlying the biosynthesis of polysaccharide in tuber plants PeerJ (IF 2.7) Pub Date : 2024-03-07
Tuber plants are of great significance in the world as human food crops. Polysaccharides, important metabolites in tuber plants, also serve as a source of innovative drugs with significant pharmacological effects. These drugs are particularly known for their immunomodulation and antitumor properties. To fully exploit the potential value of tuber plant polysaccharides and establish a synthetic system
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Heavy grazing reduces soil bacterial diversity by increasing soil pH in a semi-arid steppe PeerJ (IF 2.7) Pub Date : 2024-03-07 Xiaonan Wang, Chengyang Zhou, Shining Zuo, Yixin Ji, Wenxin Liu, Ding Huang
Background In a context of long-term highly intensive grazing in grassland ecosystems, a better understanding of how quickly belowground biodiversity responds to grazing is required, especially for soil microbial diversity. Methods In this study, we conducted a grazing experiment which included the CK (no grazing with a fenced enclosure undisturbed by livestock), light and heavy grazing treatments
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Identification and transcriptomic profiling of salinity stress response genes in colored wheat mutant PeerJ (IF 2.7) Pub Date : 2024-03-06 Min Jeong Hong, Chan Seop Ko, Jin-Baek Kim, Dae Yeon Kim
Background Salinity is a major abiotic stress that prevents normal plant growth and development, ultimately reducing crop productivity. This study investigated the effects of salinity stress on two wheat lines: PL1 (wild type) and PL6 (mutant line generated through gamma irradiation of PL1). Results The salinity treatment was carried out with a solution consisting of a total volume of 200 mL containing
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Characterization of PYL gene family and identification of HaPYL genes response to drought and salt stress in sunflower PeerJ (IF 2.7) Pub Date : 2024-03-07 Zhaoping Wang, Jiayan Zhou, Jian Zou, Jun Yang, Weiying Chen
In the context of global climate change, drought and soil salinity are some of the most devastating abiotic stresses affecting agriculture today. PYL proteins are essential components of abscisic acid (ABA) signaling and play critical roles in responding to abiotic stressors, including drought and salt stress. Although PYL genes have been studied in many species, their roles in responding to abiotic
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Collaborative clinical reasoning: a scoping review PeerJ (IF 2.7) Pub Date : 2024-03-06 Ching-Yi Lee, Hung-Yi Lai, Ching-Hsin Lee, Mi-Mi Chen, Sze-Yuen Yau
Background Collaborative clinical reasoning (CCR) among healthcare professionals is crucial for maximizing clinical outcomes and patient safety. This scoping review explores CCR to address the gap in understanding its definition, structure, and implications. Methods A scoping review was undertaken to examine CCR related studies in healthcare. Medline, PsychInfo, SciVerse Scopus, and Web of Science
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Unsupervised AI reveals insect species-specific genome signatures PeerJ (IF 2.7) Pub Date : 2024-03-06
Insects are a highly diverse phylogeny and possess a wide variety of traits, including the presence or absence of wings and metamorphosis. These diverse traits are of great interest for studying genome evolution, and numerous comparative genomic studies have examined a wide phylogenetic range of insects. Here, we analyzed 22 insects belonging to a wide phylogenetic range (Endopterygota, Paraneoptera
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A new sports garment with elastomeric technology optimizes physiological, mechanical, and psychological acute responses to pushing upper-limb resistance exercises PeerJ (IF 2.7) Pub Date : 2024-03-06 Angel Saez-Berlanga, Carlos Babiloni-Lopez, Ana Ferri-Caruana, Pablo Jiménez-Martínez, Amador García-Ramos, Jorge Flandez, Javier Gene-Morales, Juan C. Colado
This study aimed to compare the mechanical (lifting velocity and maximum number of repetitions), physiological (muscular activation, lactate, heart rate, and blood pressure), and psychological (rating of perceived exertion) responses to upper-body pushing exercises performed wearing a sports elastomeric garment or a placebo garment. Nineteen physically active young adults randomly completed two training
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Scalable neighbour search and alignment with uvaia PeerJ (IF 2.7) Pub Date : 2024-03-06 Leonardo de Oliveira Martins, Alison E. Mather, Andrew J. Page
Despite millions of SARS-CoV-2 genomes being sequenced and shared globally, manipulating such data sets is still challenging, especially selecting sequences for focused phylogenetic analysis. We present a novel method, uvaia, which is based on partial and exact sequence similarity for quickly extracting database sequences similar to query sequences of interest. Many SARS-CoV-2 phylogenetic analyses
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Hsa_circ_0001615 downregulation inhibits esophageal cancer development through miR-142-5p/β-catenin PeerJ (IF 2.7) Pub Date : 2024-03-04 Yukai Dai, Qizhong Xu, Manqi Xia, Caimin Chen, Xinming Xiong, Xin Yang, Wei Wang
Background Recent studies have found that circular RNAs (circRNAs) play important roles in tumorigenesis. This study aimed to determine the function and potential mechanisms of hsa_circ_0001615 in esophageal cancer. Methods Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the expression of hsa_circ_0001615 and miR-142-5p. Subsequently, 3-(4,5-di
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MicroCT illuminates the unique morphology of Shiinoidae (Copepoda: Cyclopoida), an unusual group of fish parasites PeerJ (IF 2.7) Pub Date : 2024-03-04 James P. Bernot, Geoffrey A. Boxshall, Freya E. Goetz, Anna J. Phillips
The copepod family Shiinoidae Cressey, 1975 currently comprises nine species of teleost parasites with unusual morphology and a unique attachment mechanism. Female shiinoids possess greatly enlarged antennae that oppose a rostrum, an elongate outgrowth of cuticle that originates between the antennules. The antennae form a moveable clasp against the rostrum which they use to attach to their host. In
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Identification and validation of shared gene signature of kidney renal clear cell carcinoma and COVID-19 PeerJ (IF 2.7) Pub Date : 2024-03-04 Jianqiang Nie, Hailang Yang, Xiaoqiang Liu, Wen Deng, Bin Fu
Background COVID-19 is a severe infectious disease caused by the SARS-CoV-2 virus, and previous studies have shown that patients with kidney renal clear cell carcinoma (KIRC) are more susceptible to SARS-CoV-2 infection than the general population. Nevertheless, their co-pathogenesis remains incompletely elucidated. Methods We obtained shared genes between these two diseases based on public datasets
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Effectiveness of Bacillus subtilis ANT01 and Rhizobium sp. 11B on the control of fusarium wilt in pineapple (Ananas comosus) PeerJ (IF 2.7) Pub Date : 2024-03-04 Lourdes Adriano-Anaya, Luis Fernando Pardo-Girón, Miguel Salvador-Adriano, Miguel Salvador-Figueroa, Isidro Ovando-Medina, Benjamin Moreno-Castillo
Pineapple (Ananas comosus) is commonly infected by Fusarium oxysporum, causal agent of the fusarium wilt disease. Conventionally, growers use synthetic fungicides to control the disease, which lead to environmental pollution, hazardous effects on non-target organisms and risks on human health. The aim of this work was to assess the effectiveness of Bacillus subtilis ANT01 and Rhizobium sp. 11B to control
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From caves to seamounts: the hidden diversity of tetractinellid sponges from the Balearic Islands, with the description of eight new species PeerJ (IF 2.7) Pub Date : 2024-03-04
The sponge fauna of the Western Mediterranean stands as one of the most studied in the world. Yet sampling new habitats and a poorly studied region like the Balearic Islands highlights once again our limited knowledge of this group of animals. This work focused on demosponges of the order Tetractinellida collected in several research surveys (2016–2021) on a variety of ecosystems of the Balearic Islands
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Serum immunoglobulin M is associated with the severity of coronary artery disease in adults PeerJ (IF 2.7) Pub Date : 2024-03-05
Purpose The purpose of this study was to investigate the relationship between serum immunoglobulin M (IgM) and the severity of coronary artery disease in Chinese patients who underwent coronary angiography. Methods A total of 2,045 patients who underwent coronary angiography (CAG) from March 2017 to March 2020 at Beijing Hospital were included in this study. Serum IgM concentration and biochemical
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Investigating the epidemiological relevance of secretory otitis media and neighboring organ diseases through an Internet search PeerJ (IF 2.7) Pub Date : 2024-03-05 Cheng Guo, Linlin Pan, Ling Chen, Jinghua Xie, Zhuozheng Liang, Yongjin Huang, Long He
Background This study examined the epidemiological correlations between secretory otitis media (SOM) and diseases of neighboring organs. We measured changes in disease incidences during the 2020 COVID-19 pandemic using Internet big data spanning from 2011 to 2021. Methods This study used the Baidu Index (BI) to determine the search volume for the terms “secretory otitis media (SOM)”, “tonsillitis”
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Tracking mosquito-borne diseases via social media: a machine learning approach to topic modelling and sentiment analysis PeerJ (IF 2.7) Pub Date : 2024-03-01
Mosquito-borne diseases (MBDs) are a major threat worldwide, and public consultation on these diseases is critical to disease control decision-making. However, traditional public surveys are time-consuming and labor-intensive and do not allow for timely decision-making. Recent studies have explored text analytic approaches to elicit public comments from social media for public health. Therefore, this
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Bimetallic nanoparticles and biochar produced by Adansonia Digitata shell and their effect against tomato pathogenic fungi PeerJ (IF 2.7) Pub Date : 2024-03-01 Reham M. Aldahasi, Ashwag Shami, Afrah E. Mohammed
Adansonia digitata L. is a royal tree that is highly valued in Africa for its medicinal and nutritional properties. The objective of this study was to use its fruit shell extract to develop new, powerful mono and bimetallic nanoparticles (NPs) and biochar (BC) using an eco-friendly approach. Silver (Ag), iron oxide (FeO), the bimetallic Ag-FeO NPs, as well as (BC) were fabricated by A. digitata fruit
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Benchmarking a targeted 16S ribosomal RNA gene enrichment approach to reconstruct ancient microbial communities PeerJ (IF 2.7) Pub Date : 2024-03-01
The taxonomic characterization of ancient microbiomes is a key step in the rapidly growing field of paleomicrobiology. While PCR amplification of the 16S ribosomal RNA (rRNA) gene is a widely used technique in modern microbiota studies, this method has systematic biases when applied to ancient microbial DNA. Shotgun metagenomic sequencing has proven to be the most effective method in reconstructing
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The destructive subterranean termite Reticulitermes flavipes (Blattodea: Rhinotermitidae) can colonize arid territories PeerJ (IF 2.7) Pub Date : 2024-02-29
Reticulitermes flavipes, one of the most destructive subterranean termite species, has been detected for the first time in an arid territory: Lanzarote (Canary Islands, Spain). This invasive species was introduced into several countries but never such a dry region. Although there are places with presence of this termite at similar or even higher temperatures, none has annual rainfall (10.1 mm) as low
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Research and experimental verification on the mechanisms of cellular senescence in triple-negative breast cancer PeerJ (IF 2.7) Pub Date : 2024-02-29
Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with high heterogeneity, poor prognosis, and a low 10-year survival rate of less than 50%. Although cellular senescence displays extensive effects on cancer, the comprehensions of cellular senescence-related characteristics in TNBC patients remains obscure. Method Single-cell RNA sequencing (scRNA-seq) data were
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Molecular cloning and characterization of farnesyl diphosphate synthase from Rosa rugosa Thunb associated with salinity stress PeerJ (IF 2.7) Pub Date : 2024-02-29 Guo Wei, Yudie Chen, Jianwen Wang, Liguo Feng
Rosa rugosa, a renowned ornamental plant, is cultivated for its essential oil containing valuable monoterpenes, sesquiterpenes, and other compounds widely used in the floriculture industry. Farnesyl diphosphate synthase (FPPS) is a key enzyme involved in the biosynthesis of sesquiterpenes and triterpenes for abiotic or biotic stress. In this study, we successfully cloned and characterized a full-length
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Regional trends in the moderate-to-vigorous intensity physical activity and screen time of Canadians before and during the COVID-19 pandemic PeerJ (IF 2.7) Pub Date : 2024-02-29 Travis Saunders, Rachel C. Colley
Background During the COVID-19 pandemic, public health approaches and disease-transmission varied widely across Canadian regions. This may have led to different trajectories for moderate-to-vigorous intensity physical activity (MVPA) and screen time during this period. The purpose of this investigation was to describe age- and gender-specific regional trends in MVPA and screen time for Canadian youth
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Changes in capture availability due to infection can lead to detectable biases in population-level infectious disease parameters PeerJ (IF 2.7) Pub Date : 2024-02-29
Correctly identifying the strength of selection that parasites impose on hosts is key to predicting epidemiological and evolutionary outcomes of host-parasite interactions. However, behavioral changes due to infection can alter the capture probability of infected hosts and thereby make selection difficult to estimate by standard sampling techniques. Mark-recapture approaches, which allow researchers
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Intensive pasture management alters the composition and structure of plant-pollinator interactions in Sibiu, Romania PeerJ (IF 2.7) Pub Date : 2024-02-29 Ana-Maria Neacă, Julia Meis, Tiffany Knight, Demetra Rakosy
Background Land management change towards intensive grazing has been shown to alter plant and pollinator communities and the structure of plant-pollinator interactions in different ways across the world. Land-use intensification in Eastern Europe is shifting highly diverse, traditionally managed hay meadows towards intensive pastures, but few studies have examined how this influences plant-pollinator
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Regulation of soldier caste differentiation by microRNAs in Formosan subterranean termite (Coptotermes formosanus Shiraki) PeerJ (IF 2.7) Pub Date : 2024-02-29
The soldier caste is one of the most distinguished castes inside the termite colony. The mechanism of soldier caste differentiation has mainly been studied at the transcriptional level, but the function of microRNAs (miRNAs) in soldier caste differentiation is seldom studied. In this study, the workers of Coptotermes formosanus Shiraki were treated with methoprene, a juvenile hormone analog which can