Coal bed methane reservoirs possess low to ultra-low permeability. In order to improve the production from CBM wells, stimulation techniques were deployed. This article reviews the most cost-effective, time-saving, and eco-friendly fracturing fluid which is a mix of water, guar gum, and sodium acetate. This article also provides a detailed study of hydraulic fracturing in unconventional reservoirs

Probiotic Enterococcus strains of human origin were microencapsulated by spray drying using whey protein and maltodextrin as an encapsulating agent. The obtained encapsulates were characterized for stability, viability, and physiological properties. The microcapsules were prepared from probiotic Enterococcus strains that were previously isolated from human vagina and infants’ meconium. The microcapsules

Specific heat capacity is one of the prominent and deciding factors for selection of thermal insulation materials in thermal engineering. In recent times, there has been a great advancement in the manufacturing of a variety of advanced materials in order to meet the modern needs for thermal insulation. Unfortunately, certain drawbacks like high cost of procurement, low accuracy, and limited suitability

Algae in general characterized by their rich content of biological compounds. However, few studies were conducted on the soil-inhabiting algae and their antioxidant characteristics. The present study was designed to evaluate the antioxidant activity of four edaphic algae including one on-soil alga (Vaucheria geminata) and three axenic isolated in-soil algae (Pleurochloris pyrenoidosa, Botrydiopsis

There are many biomarkers associated with breast cancer. Higher expression of PIK3CA (Phosphoinositide 3-kinase Cα), in its upregulated form, is associated with Hr+ and Her2− breast cancer; therefore, many drugs were synthesized against this protein to treat breast cancer patients. FDA recently approved that the drug alpelisib also inhibits PI3KCα (PDB ID-5DXT) in BC patients with Hr+ and Her2−. In

Propolis is a natural product that has been widely utilized as medicine and dietary supplement because of its broad biological activities. However, although meliponide hive products have many advantages, meliponiculture has not yet become popular in Argentina, and few scientific studies on its chemical composition and/or its bioactive properties were reported, so the use of stingless bee propolis Argentine

In this study, the chronic wound healing ability of PLA-based electrospun nanofibers loaded with hyaluronic acid, valsartan, and ascorbic acid is explored. PLA-based scaffolds were fabricated by electrospinning, followed by loading the scaffolds with different concentrations of hyaluronic acid, valsartan, and ascorbic acid hydrogels. The produced formulations were characterized by scanning electron

Quinazolin-4(1H)-one nucleus has attracted the attention of medicinal chemists due to their clinical uses. Modification of quinazolinone ring for the development of pharmaceutical and clinical compound for its anti-inflammatory potential. In vitro anti-inflammatory activity of the synthesized compounds was performed by using egg albumin protein denaturation assay, while in vivo anti-inflammatory activity

Prostate cancer is the most common non-cutaneous cancer in males and accounts for about 4% of all cancer-related deaths in males annually. In silico methods provide faster, economical, and environmentally friendly alternatives to the traditional trial and error method of lead identification and optimization. This study, therefore, was aimed at building a robust QSAR and QSTR model to predict the anti-proliferate

The kinetics and statistical analysis of crude oil (CO) degradation in CO-contaminated soil (COCS) using goat litter (GL) were investigated. The data obtained from the CO degradation process was fitted to the first- and second-order kinetic models. The effects of process parameters such as temperature and the initial CO concentrations on the CO degradation process were also investigated. The one-way

Metal polluted environments have been found to harbor acid and metal tolerant bacterial communities. Metal oxidizing bacteria in particular are industrially important microorganisms that can be utilized for potential applications in biomining and bioremediation. However, some well-characterized strains are not readily culturable as they are obligate and fastidious chemolithotrophs requiring special

The present work assesses the concentration of some heavy metal, plant species composition, and microbial diversity of spent crude oil-polluted soil from electric generator plant house, auto mechanic workshop, bakery, and auto spare part shops in four local governments areas (Egor, Ikpoba-Okha, Oredo, and Ovia North) in Edo State, Southern Nigeria. Hazard quotient (HQ) of heavy metals varied in all

Lasers have been investigated as an alternative or adjunctive tool to conventional procedures commonly used in periodontology. The application of low-level laser therapy (LLLT) in dentistry was proposed to provide minimally invasive and painless treatment as well as increasing the comfort for the patient following surgery. Thus, the purpose of the current study was to evaluate the effect of LLLT on

Cyclophosphamide (CP) is a cytotoxic anticancer drug used for the treatment of neoplastic diseases. The present study aimed to examine biochemical, histological, and ultrastructural effects of CP on rat liver and determine the hepatoprotective effects of alpha-lipoic acid (LA) or royal jelly (RJ) against CP. The present study revealed that CP-induced significant increase in hepatic marker enzymes (ALT

Quantitative structure-activity relationships (QSAR) is a technique that is used to produce a model that connects biological activities of compounds to their chemical structures, and molecular docking is a technique that reveals the binding mode and interactions between a drug and its target enzyme. These techniques have been successfully applied in the design and development of many drug candidates

Peel is one of the major by-products in fruit processing industry. Fruit products (non-edible parts) are also considered as waste products and often discarded in the environment. Fruit peels are now serving as one of the primary sources for isolation and extraction of secondary metabolites in pharmaceutical industry. The present investigation was carried out to screen the phytochemical constituents

For centuries, people have been using clay or earthen pots for cooking. Also, many studies indicated a contrariety from safety or danger of it. Our study aims to assess the lead concentration in boiling water in clay pots. Contaminated the diet with lead acetate and evaluated the nutritional, biochemical statues, and histological studies for male albino rats. Step A: Ten samples of the distilled water

Adult worms of Setaria equina mainly found in the peritoneal cavity of equine. They were nonpathogenic but might induce varied degrees of peritonitis and might migrate to the eye, brain, lung, and scrotum causing lacrimation, blindness, paraplegia, locomotor, and neurological disturbances. Identification by light microscopy is insufficient to differentiate Setaria species, and so scanning electron

Breast cancer is a major form of health problem on the globe and the second cause of death related to cancer amidst women. A prediction of about 1 to 1.3 million cases on cancer of the breast are detected yearly globally. Triple-negative type of breast cancers (TNBCs) are described by the lack of human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER), and progesterone receptor (PR)

Carica papaya is an eminent medicinal plant used all over the world to treat several diseases like malaria, dengue, inflammation, and skin infections. In this study, preliminary phytochemical screening for C. papaya flowers was carried out using different methods as TLC screening and UV-spectroscopy along with evaluation of antioxidant and antibacterial activities. Methods were also developed for TLC

The main objective of this study is to compare the effectiveness of toothpaste formulations in giving total protection to the oral cavity. So, three important solution properties: surface tension, conductivity, and pH measurements, have been investigated for eight kinds of commercial herbal and non-herbal based toothpaste of Nepal. The study was extended to evaluate the antibacterial efficacy of toothpaste

Three-dimensional printing (3DP) is an emerging technology used to describe 3D products manufactured on a digital design platform and in a layer by layer fashion. 3D printing technology has appeared as a major technological revolution of the recent years leading to the manufacturing and production of novel medical products and devices in pharmaceutical industry. The new technology has gained considerable

Swine influenza A viruses (SIV) infection is among the leading causes of respiratory diseases in a number of animal species and human, and has been reported to cause substantial losses to pig industry. Previous reports of serological, molecular, and surveillance studies in commercial piggeries in Nigeria indicated the presence of SIV subtypes H1N1 and H3N2 in infected pigs; hitherto, there exists lack

Pyrazole-furan and pyrazole-pyrrole moiety are among the molecular structures that were found to have an extensive range of applications in the field of medicine and agrochemical due to their wide spectrum of biological activities. These include antimicrobial activity, anti-glaucoma activity, ocular hypertension activity, and antifungal activity. An in silico study was carried out on 37 compounds of

The present investigation is designed to evaluate the antioxidant and protective efficacy of the brown alga, Hydroclathrus clathratus (C.Agardh) M. Howe, against copper-induced lung injury in male albino rats. The present study was carried out on 24 adult male albino rats, they were randomly divided into four groups (n = 6) (A group, control rats; B group, rats received 100 mg/kg body weight of H.

The 1,3,4-thiadiazoles are among the structural moieties that were found to be of utmost importance in the fields of pharmacy and agrochemicals because of their widespread biological activity that includes anti-tumor, antibacterial, anti-inflammatory, antihypertensive, anti-tuberculosis, anticonvulsant, and antimicrobial, among others. QSAR and molecular docking studies were carried out on thirty-two

Quinazoline are known to possess different biological activities which among is anti-cancer most especially NSCLC. Epidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinases (RTKs) family, which is known to be one of the most important therapeutic targets for the treatment of cancer most especially NSCLC. QSAR modeling was performed to develop a model with high predictive power

Nanotechnology has been receiving wonderful impetus in the current emerging technological era by opening a pool of scientific ideas to compete with the daily challenges of developing technology. So far, numerous properties and countless applications of nanomaterials have been explored which have been even proved to be based on characteristic shape, size, surface area and surface chemistry. By the time

E-commerce services provide online shopping sites and mobile applications for small and medium sellers. To provide more efficient buying and selling experiences, a machine learning system can be applied to predict the optimal organization and display of products that maximize the chance of bringing useful information to user that facilitate the online purchases. Therefore, it is important to understand

The present study identified, quantified, and characterized the combinations of phytocomponents from fractionated leaf extracts of Anacardium occidentale, Psidium guajava, and Terminalia catappa that stabilized sickle erythrocyte membrane against osmotic stress, or otherwise, using standard chromatographic-spectrophotometric techniques, namely GC-MS, FT-IR, and UV-visible systems. The percentage hemolysis

BiFeO3 shows promising applications in photocatalytic degradation, purification process, and in clean energy generation. The various fascinating properties of bismuth ferrite nanoparticles can be improved by doping the material at either of the A or B sites to give it extra photocatalytic advantage toward decreasing the energy bandgap and other photophysical properties of the material. In this research

Glaucoma is a complex multivariate disorder characterized by retinal ganglion cell (RGC) loss and optic nerve degeneration. Evidence suggests the role of estradiol (E2) and the etiology of glaucoma. Therefore, this present study evaluates the association between estrogen-signaling pathways and the risk of open-angle glaucoma (OAG). Meta-analysis was performed from available studies that investigated

Cardiopulmonary health and its relationship with diabetes mellitus are very important but particularly underexplored in young undergraduate students of private Universities in Nigeria. This observational study investigated the effect of diabetic risk on cardiopulmonary health indices among healthy, consenting undergraduate students of a private university in Nigeria by a convenient sampling method

Many of the pathogenic microbes use trehalose–6–phosphate phosphatase (TPP) enzymes for biosynthesis of sugar trehalose from trehalose–6–phosphate (T6P) in their pathway of infection and proliferation. Therefore, the present work is an approach to design new generation candidate drugs to inhibit TPP through in silico methods. Blast P and Clustal Omega phylogenetic analysis of TPP sequences were done

This research provides a comprehensive analysis of QSAR modeling performed on 25 aryl sulfonamide derivatives to predict their effective concentration (EC50) against H5N1 influenza A virus by using some numerical information derived from structural and chemical features (descriptors) of the compounds to generate a statistically significant model. Subsequently, the molecular docking simulations were

Carboxymethyl chitosan (CMCh) is a water-soluble chitosan derivative and it has been widely used in biomedical applications due to its unique properties. Modification of CMCh by graft copolymerization with different monomers is done in order to enhance its applications. Graft copolymerization of styrene (S) onto CMCh using ammonium persulfate (APS) as initiator was successfully done with optimization

Marine algae used as a food source for ocean life and range in color from red to green to brown grow along rocky shorelines around the world. The synthesis of silver nanoparticles by marine alga Padina sp. and its characterization were fulfilled by using UV-visible spectrophotometer, Fourier transform infrared spectroscopy, scanning electron microscopy and field emission scanning electron microscopy

Among all available dosage form, tablet is most widely used because of its stability and patient acceptability. The better aesthetic quality like color, texture, mouth feel, and taste masking depended on film and sugar coatings, so the coating is an important part in the formulation of the tablet. The present work aims to comprehensively review the formulation, characterization, and challenges in the

Cesarean delivery (c-section) is on the rise globally. C-section is generally preferred if complications prevail in a vaginal delivery. Some private institutions conduct it unnecessarily for economic gains. This has led to a severe risk to a child’s health. The neonate’s gut microbiota has been observed to be influenced by the mode of delivery. Lactobacilli and other bacteria are very vital for developing

Ipomoea mauritiana is one of the source plants of Vidari, an Ayurvedic drug used as Medhyarasayana (rejuvenating drug). In this current study, coumarins were separated from tuberous root of I. mauritiana and characterization of the coumarin fraction was done by LC-MS/MS analysis by atmospheric pressure chemical ionization method. Anti-amnesic activity was evaluated against scopolamine induced amnesia

Though downward longwave radiation (DLR) models curb the paucity of data, they are mostly location dependent. Therefore, there is a need to evaluate their relevance given the increasing use of machine learning techniques. In this study, cloudless DLR estimates from regression models and soft computing models of neural networks (NN), support vector regression (SVR) and adaptive neuro-fuzzy inference

Sickle cell disease (SCD) is a chronic hemolytic disease caused by an altered hemoglobin molecule (HbS) and was first termed as a molecular disease. Glutamic acid in the normal hemoglobin molecule (HbA), was replaced by valine in HbS at the sixth position of both β-chains. This alteration was proved to be due to a single point mutation GTG instead of GAG in the genetic code. Since the discovery of

Adenanthera pavonina L. is an important medicinal plant and its barks are used in traditional medicine for treating different diseases. Therefore, a phytochemical investigation was carried out to isolate and identify secondary metabolites from its barks. Seven compounds namely ethyl 3,3-dimethyl-13-hydroxytridecanoate (1), stigmasta-5,22-dien-3β-ol (2), tert.butyl tridecanoate (3), 6-α-hydroxy sti

The liver is the largest important organ and the site for essential biochemical reactions and detoxifying toxic substances in the human body. Long-term, high-dose dexamethasone administration can cause severe alterations in liver function. Therefore, Thymus vulgaris leave extract possess a modulatory role on dexamethasone-induced hepatotoxicity by attenuating antioxidant defense system. By subcutaneous

Plants are usually the target of environmental pollution. This study, therefore, investigates the effects of Zinc (Zn) and lead Pb on Bambara nut (Vigna subterranean) and Maize (Zea mays) at different concentrations, as well as the possible ameliorating effect of the chelant; ethylene diamine acetate (EDTA) and farmyard manure, on the enzymatic activities, the chlorophyll, total protein, and carbohydrate

Antibiotic resistance and dearth of novel compounds from natural sources warrants the need to search other environments for potential antibiotic-producing microbial species. The study investigated isolation and identification of antibiotic-producing fungi from pharmaceutical waste sludge. Seven hundred and ninety-seven isolates obtained from sludge of seven pharmaceutical industries in Sango Ota, Ogun

Several phytochemical constitutes possess natural antioxidant activity and are in fact advantageous in reducing many oxidative stress related diseases. Drymaria diandra of Caryophyllaceae family is one such plant which exhibits various medicinal properties. The aim of the current study is to provide detailed exploration of phytochemical constitutes, metal concentration determination, antioxidant, and

One of the serious public health problems in the world is metabolic syndrome. It includes visceral obesity, dyslipidemia, insulin resistance, hyperglycemia, and hypertension. As a contributor to almost all the classic signs of metabolic syndrome, fructose was the ideal choice. There are certain shortcomings with existing drugs for insulin-resistant treatment. Plants still represent the main source

There is a renewed global interest in plant-based medicine in the last few decades as a result of affordability and efficacy of the form of medicine. However, the safety of many medicinal plants and plant preparations has not been determined. To this end, this study determined the safety of the methanol extracts of the leaves of Guiera senegalensis, Cassia occidentalis, and Ziziphus mauritiana, which

DNA in a human cell is subjected to constant assault from both environmental factors and normal metabolic processes. Accumulation of DNA damage drives the progression of many health disorders like aging, cancer, diabetes, and neurodegenerative disorders. The present study focuses on the isolation of phenolic compound from the fruit of Terminalia chebula and its protective role on induced DNA damage

In the present study, phylogenetic relationships within Heterobranchia in particular to Pulmonata were evaluated by means of Histone-3 (H3) gene sequence information. H3 gene is a slow evolving marker and is useful in resolving the deep level relationships. This is the first study to report the phylogeny of Pulmonata with more number of representatives from the group on the basis of H3 gene. The major

Cadmium (Cd) toxicity, which runs across the food chain, is chiefly regulated by in vivo antioxidant defence system or through antioxidant supplementation of biological systems predisposed to this environmental stressor. The present study was designed to examine the role of Anthocleista vogelii leaves in Cd-induced oxidative stress in the serum of Wistar rats through the application of response surface

Antioxidants are very crucial in maintaining the normal function of body cells, as they scavenge excess free radical in the body. A set of hydrazone antioxidants was designed by in silico screening. The density functional theory (DFT) method was employed to explore the reaction energetics of their free radical-scavenging mechanism. With the aid of the developed quantitative structure-activity relationship

The Klf6 gene, which belongs to Krüppel-like family of C2H2 zinc finger transcription factors, is greatly related to tumorigenesis via a high rate of somatic mutation in the carcinomas of prostate, liver, colon, stomach, lung, neck, pituitary, and nervous system: Furthermore, the pathways regulating the expressions of Klf6 splice variants termed Klf6-SV1, -SV2, and -SV3 remain obscure although their

Cyanobacterium-based silver nanoparticles are considered not only as an efficient nano-nematicide but also as a bio-stimulant material for plant growth. They could be employed as a part of an integrated program for controlling some plant diseases. In this study, silver nanoparticles (Ag-NPs) were biosynthesized from aqueous extract of the cyanobacterium, Nostoc sp. PCC7524. Full characterization of

Neurotransmitters are involved in several functions in the brain and the body of living things. Changes in the level of neurotransmitters in the brain are associated with several illnesses. Some of the drugs are controlling the neurotransmitter by adjusting the level in the brain and are exclusively used in the treatment of psychological disorders. The purpose of the study was to find out the effect

It is comprehensively recognized that reduced reproductive efficiency represents a great economic loss to dairy producers. Ovarian cysts and anestrus syndromes are considered the greatest significant causes of low reproductive efficiency in dairy herds worldwide as they detrimentally affect the longevity and profitability of dairy herd. Pregnancy rate is the best available single deciding parameter

8-Hydroxyquinoline derivatives are known for their extensive applications in the field of analytical chemistry and separation techniques; their complexes with transition metals also exhibit antibacterial and antifungal activity. In the present study, we synthesized a new series of pyranoquinoline derivatives and evaluated their antibacterial activities. The structures of the synthesized compounds were

ATP-binding cassette (ABC) transporters constitute one of the largest transporter protein families and play a role in diverse biological processes. In the present study, bacteriocin isolated from the Enterococcus casseliflavus MI001 strain was identified as an ABC transporter ATP-binding protein. The optimal conditions for the production of bacteriocin were found to be at 35 °C, a pH 5.5, and an incubation

Cassia sophera Linn is a medicinally important plant belonging to the family of Caesalpiniaceae. The whole part of the plant is used as traditional folk medicine and is reported to possess analgesic, anticonvulsant, antioxidant, anti-inflammatory, hepatoprotective, and antiasthmatic activity. The present communication attempt is to evaluate fatty acids from different parts of the plant by GC-MS spectrophotometer