Enantiomerically pure (R)-β-hydroxy-1,2,3-triazole derivatives, which are important β-blocker analogues, have been synthesized by exploiting an unusual Prelog enantioselective reduction of aromatic azido ketones by whole cells of a lactic acid bacterium (Weissella cibaria C43-11) and a “click” cycloaddition reaction carried out in Deep Eutectic Solvents, under heterogeneous and aerobic conditions at

Reaction kinetic modeling, model-based optimization and experimental validation are performed for the direct synthesis of dimethyl ether from CO2 rich synthesis gas. Among these disciplines, experimental methods and models are aligned in a stringent way of action, i.e., the same setup and models are applied throughout the whole contribution. First, a lumped reaction kinetic model from the literature

Aromatic C-H functionalization reactions are an important part of the synthetic chemistry toolbox.Accurate prediction of site selectivity can be crucial for prioritizing target compounds and synthetic routes in both drug discovery and process chemistry. However, selectivity may be highly dependent on subtle electronic and steric features of the substrate. We report a generalizable approach to prediction

This contribution in the special issue of Synthesis 4.0 highlights the unavoidable connection between the manual or self optimized flow synthesis protocols for multistep flow synthesis and its scale-up. While briefly summarizing the state of the art in self optimization approach, a brief summary of industrially scaled-up processes is also given. We have used a case study of flow synthesis of Ivacaftor

1,3-Butadienes play a key role in modern synthetic chemistry and biochemistry because they are well-known precursors for the synthesis of retinoids. A new and efficient synthesis of 3-trifluoromethylated 1,3-butadienes via Pd(0)-catalyzed fluorinated Heck reaction is described. Without additive, 2-bromo-3,3,3-trifluoropropene, an abundant and ozone friendly CF3 building block with acrylamides afforded