Biomass particles separation has been found challenging because of particle's smallness and lightness in pharmaceutical industry. Centrifugation has been used conventionally for batch separation. However, imposing multi wash steps in order to eliminate culture residues and high risk of extrinsic contamination hamper batch techniques. In this research mini‐hydrocyclones were introduced to provide better

Traditional operating performance assessment approaches mainly focus on the steady state. However, the assessment indicators designed for the steady state cannot be directly applied to the transition state. Moreover, identifying process state for multivariable system is difficult and time consuming. Hence, an operating performance assessment method for the transition state is developed in the paper

The continuous flow production of active pharmaceutic ingredients is a spreading applicative research field. Process simulation tools are effective means for in silico process design, but care is needed. A paradigmatic example is the synthesis of ibuprofen. First the most appropriate thermodynamic models must be selected. The rich databases now available to collect thermodynamic properties are often

In this study, the weeping phenomenon was investigated using some tests and a numerical model. The tests were performed within a 1.22 m‐diameter pilot‐scale column including two chimney trays and two Nye test trays by the air‐water system. The rates of weeping were measured in Nye trays with two heights of the weir and a 5% hole area. Moreover, the weeping rate in outlet half and inlet half of the

Multiple emulsions (ME) are of interest as carrier of active ingredients that can be released in a controlled way. ME are thermodynamically unstable with a strong tendency to coalesce or flocculate, resulting in a complex emulsion generation and stabilization process. Typical encapsulation procedures utilize individual batch operation steps for the ME production.

The current study's aim is oxidative enzyme extraction from tea leaves and the assessment of their activation. Taguchi approach was used for the design, optimization and statistical analysis of polyphenol oxidase (PPO) and peroxidase (POD) extraction. It was found that PPO and POD have the highest activity at temperature of 50 °C, pH= 9 and 5 for PPO and POD, buffer solution concentration of 0.05,

Two different approaches can be applied to calculate mass transfer in a two‐phase system using Computational Fluid Dynamics and the Volume‐of‐Fluid method, single‐field and two‐field approaches. The used method affects the stability of the calculation as well as the accuracy of the result. In this article, we compare two Volume‐of‐Fluid based approaches: the Generalised Continuous Species Transfer

Aerosols represent a health risk since small droplets may enter the respiratory system and cause lung cancer, allergies, or diseases like COVID‐19. In this work, an Eulerian‐Lagrangian CFD model is used based on a voxel‐based (GeoDict) and a mesh‐based (StarCCM+) code. For evaluating accuracy and computational time of both models, we compare fractional filtration efficiency and pressure drop to an

The application of heat storage systems in households or industry is one possibility to optimize the degree of heat utilization and reduce greenhouse gas emissions. In contrast to established heat storage systems based on water, zeolitic systems reach energy densities of 150 – 200 kWh m‐³ and allow for seasonal storage with almost no heat loss. However, a commercial breakthrough was not successful

The micro‐mixing in the coiled micro‐reactors is attained by a higher pressure drop and more pumping power. The study tries to obtain the optimum geometries of the helically coiled micro‐reactors by the multi‑objective optimization based on genetic algorithm (GA). The segregation index (Xs) values of the Villermaux/Dushman reaction were measured in twelve coiled micro‐channels. The effects of the geometries

First and second Lyapunov's method were adapted here to analyze the stability of a tubular chemical reactor with recycle. The criterion of local stability, in the form of inequalities, was derived using Lyapunov's first method. It is an explicit algebraic form, despite the fact that the mathematical model of the reactor is a partial differential problem with an boundary condition. As part of the second

The microchannel heat sink is an effective technology for the thermal management of Li‐ion batteries. The purpose of the paper is to determine the overall performance of two heat sinks which are better in thermal management of Li‐ion battery by the numerical simulation model. MMC (manifold microchannel heat sink) and TMC (traditional microchannel heat sink) with different aspect ratios of microchannel

In the context of the application of optimization technologies in the refining industry, a new FCC lumped kinetic modeling method was put forward to improve the prediction accuracy of the FCC kinetic model. The kinetic model divided the feedstock into three lumps: crackable hydrocarbon (HCK), intermediate hydrocarbon (HI) and condensable hydrocarbon (HCD) according to the catalytic cracking reaction

In the current paper, a large‐scale dimethyl carbonate (DMC) production process from ethylene oxide (EO), CO2 and methanol, was simulated and optimized. Unlike most industrial processes of DMC production, the direct conversion of EO and CO2 to ethylene carbonate (EC) and EC transesterification to DMC was performed in a single‐reactor. The reaction volume and the reactor operating pressure were selected

Medium temperature shift (MTS) reaction was investigated in microchannel reactor using electrophoretic deposition (EPD) method to coat porous layers of Ni‐K/CeO2 catalyst on stainless steel plates. The electrolyte suspensions of catalyst were prepared in isopropanol, ethanol, methanol, and acetone solvents. All of the experiments for EPD were carried out at similar conditions (i.e. contact time of