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How Do Cells Adapt? Stories Told in Landscapes. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Luca Agozzino,Gábor Balázsi,Jin Wang,Ken A Dill
Cells adapt to changing environments. Perturb a cell and it returns to a point of homeostasis. Perturb a population and it evolves toward a fitness peak. We review quantitative models of the forces of adaptation and their visualizations on landscapes. While some adaptations result from single mutations or few-gene effects, others are more cooperative, more delocalized in the genome, and more universal
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Mechanistic Modeling of Preparative Column Chromatography for Biotherapeutics. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Vijesh Kumar,Abraham M Lenhoff
Chromatography has long been, and remains, the workhorse of downstream processing in the production of biopharmaceuticals. As bioprocessing has matured, there has been a growing trend toward seeking a detailed fundamental understanding of the relevant unit operations, which for some operations include the use of mechanistic modeling in a way similar to its use in the conventional chemical process industries
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Life and Times in Engineering and Chemical Engineering. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 J F Davidson
John Davidson was widely recognized as the founding father of fluidization in chemical engineering. He was a great thinker and had a tremendous ability to distill complicated problems into much simpler concepts. Much of his thinking was set out, along with that of his coauthor David Harrison, in their book Fluidised Particles, first published in 1963, a book that is still used today. John was still
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Molecular Modeling and Simulations of Peptide-Polymer Conjugates. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Phillip A Taylor,Arthi Jayaraman
Peptide–polymer conjugates are a class of soft materials composed of covalently linked blocks of protein/polypeptides and synthetic/natural polymers. These materials are practically useful in biological applications, such as drug delivery, DNA/gene delivery, and antimicrobial coatings, as well as nonbiological applications, such as electronics, separations, optics, and sensing. Given their broad applicability
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Cellular Automata in Chemistry and Chemical Engineering. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Natalia V Menshutina,Andrey V Kolnoochenko,Evgeniy A Lebedev
We review the modern state of cellular automata (CA) applications for solving practical problems in chemistry and chemical technology. We consider the problems of material structure modeling and prediction of materials’ morphology-dependent properties. We review the use of the CA approach for modeling diffusion, crystallization, dissolution, erosion, corrosion, adsorption, and hydration processes.
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Water Treatment: Are Membranes the Panacea? Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Matthew R Landsman,Rahul Sujanani,Samuel H Brodfuehrer,Carolyn M Cooper,Addison G Darr,R Justin Davis,Kyungtae Kim,Soyoon Kum,Lauren K Nalley,Sheik M Nomaan,Cameron P Oden,Akhilesh Paspureddi,Kevin K Reimund,Lewis Stetson Rowles,Seulki Yeo,Desmond F Lawler,Benny D Freeman,Lynn E Katz
Alongside the rising global water demand, continued stress on current water supplies has sparked interest in using nontraditional source waters for energy, agriculture, industry, and domestic needs. Membrane technologies have emerged as one of the most promising approaches to achieve water security, but implementation of membrane processes for increasingly complex waters remains a challenge. The technical
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Hydrolysis and Solvolysis as Benign Routes for the End-of-Life Management of Thermoset Polymer Waste. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Minjie Shen,Hongda Cao,Megan L Robertson
The production of thermoset polymers is increasing globally owing to their advantageous properties, particularly when applied as composite materials. Though these materials are traditionally used in more durable, longer-lasting applications, ultimately, they become waste at the end of their usable lifetimes. Current recycling practices are not applicable to traditional thermoset waste, owing to their
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Numerical Methods for the Solution of Population Balance Equations Coupled with Computational Fluid Dynamics. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Mohsen Shiea,Antonio Buffo,Marco Vanni,Daniele Marchisio
This review article discusses the solution of population balance equations, for the simulation of disperse multiphase systems, tightly coupled with computational fluid dynamics. Although several methods are discussed, the focus is on quadrature-based moment methods (QBMMs) with particular attention to the quadrature method of moments, the conditional quadrature method of moments, and the direct quadrature
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Covalent Organic Frameworks in Separation. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Saikat Das,Jie Feng,Wei Wang
In the wake of sustainable development, materials research is going through a green revolution that is putting energy-efficient and environmentally friendly materials and methods in the limelight. In this quest for greener alternatives, covalent organic frameworks (COFs) have emerged as a new generation of designable crystalline porous polymers for a wide array of clean-energy and environmental applications
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Positron Emission Particle Tracking of Granular Flows. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 C R K Windows-Yule,J P K Seville,A Ingram,D J Parker
Positron emission particle tracking (PEPT) is a noninvasive technique capable of imaging the three-dimensional dynamics of a wide variety of powders, particles, grains, and/or fluids. The PEPT technique can track the motion of particles with high temporal and spatial resolution and can be used to study various phenomena in systems spanning a broad range of scales, geometries, and physical states. We
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Life Cycle Assessment for the Design of Chemical Processes, Products, and Supply Chains. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Johanna Kleinekorte,Lorenz Fleitmann,Marvin Bachmann,Arne Kätelhön,Ana Barbosa-Póvoa,Niklas von der Assen,André Bardow
Design in the chemical industry increasingly aims not only at economic but also at environmental targets. Environmental targets are usually best quantified using the standardized, holistic method of life cycle assessment (LCA). The resulting life cycle perspective poses a major challenge to chemical engineering design because the design scope is expanded to include process, product, and supply chain
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Multiscale Lithium-Battery Modeling from Materials to Cells. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Guanchen Li,Charles W Monroe
New experimental technology and theoretical approaches have advanced battery research across length scales ranging from the molecular to the macroscopic. Direct observations of nanoscale phenomena and atomistic simulations have enhanced the understanding of the fundamental electrochemical processes that occur in battery materials. This vast and ever-growing pool of microscopic data brings with it the
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Process Control and Energy Efficiency. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Jodie M Simkoff,Fernando Lejarza,Morgan T Kelley,Calvin Tsay,Michael Baldea
We review the impact of control systems and strategies on the energy efficiency of chemical processes. We show that, in many ways, good control performance is a necessary but not sufficient condition for energy efficiency. The direct effect of process control on energy efficiency is manyfold: Reducing output variability allows for operating chemical plants closer to their limits, where the energy/economic
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Separation Processes to Provide Pure Enantiomers and Plant Ingredients. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Heike Lorenz,Andreas Seidel-Morgenstern
Enantiomer separation and the isolation of natural products from plants pose challenging separation problems resulting from the similarity of molecules and the number of compounds present in synthesis or extract mixtures. Furthermore, limited theory is available to predict productivities for possible alternative separation techniques. The application and performance of chromatography- and crystallization-based
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N-Glycosylation of IgG and IgG-Like Recombinant Therapeutic Proteins: Why Is It Important and How Can We Control It? Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Natalia I Majewska,Max L Tejada,Michael J Betenbaugh,Nitin Agarwal
Regulatory bodies worldwide consider N-glycosylation to be a critical quality attribute for immunoglobulin G (IgG) and IgG-like therapeutics. This consideration is due to the importance of posttranslational modifications in determining the efficacy, safety, and pharmacokinetic properties of biologics. Given its critical role in protein therapeutic production, we review N-glycosylation beginning with
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Water Structure and Properties at Hydrophilic and Hydrophobic Surfaces. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Jacob Monroe,Mikayla Barry,Audra DeStefano,Pinar Aydogan Gokturk,Sally Jiao,Dennis Robinson-Brown,Thomas Webber,Ethan J Crumlin,Songi Han,M Scott Shell
The properties of water on both molecular and macroscopic surfaces critically influence a wide range of physical behaviors, with applications spanning from membrane science to catalysis to protein engineering. Yet, our current understanding of water interfacing molecular and material surfaces is incomplete, in part because measurement of water structure and molecular-scale properties challenges even
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Possibilities and Limits of Computational Fluid Dynamics-Discrete Element Method Simulations in Process Engineering: A Review of Recent Advancements and Future Trends. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Paul Kieckhefen,Swantje Pietsch,Maksym Dosta,Stefan Heinrich
Fluid–solid systems play a major role in a wide variety of industries, from pharmaceutical and consumer goods to chemical plants and energy generation. Along with this variety of fields comes a diversity in apparatuses and applications, most prominently fluidized and spouted beds, granulators and mixers, pneumatic conveying, drying, agglomeration, coating, and combustion. The most promising approach
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Quorum Sensing Communication: Molecularly Connecting Cells, Their Neighbors, and Even Devices. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Sally Wang,Gregory F Payne,William E Bentley
Quorum sensing (QS) is a molecular signaling modality that mediates molecular-based cell–cell communication. Prevalent in nature, QS networks provide bacteria with a method to gather information from the environment and make decisions based on the intel. With its ability to autonomously facilitate both inter- and intraspecies gene regulation, this process can be rewired to enable autonomously actuated
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Bioprivileged Molecules: Integrating Biological and Chemical Catalysis for Biomass Conversion. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Jiajie Huo,Brent H Shanks
Further development of biomass conversions to viable chemicals and fuels will require improved atom utilization, process efficiency, and synergistic allocation of carbon feedstock into diverse products, as is the case in the well-developed petroleum industry. The integration of biological and chemical processes, which harnesses the strength of each type of process, can lead to advantaged processes
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Biological Assembly of Modular Protein Building Blocks as Sensing, Delivery, and Therapeutic Agents. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Emily A Berckman,Emily J Hartzell,Alexander A Mitkas,Qing Sun,Wilfred Chen
Nature has evolved a wide range of strategies to create self-assembled protein nanostructures with structurally defined architectures that serve a myriad of highly specialized biological functions. With the advent of biological tools for site-specific protein modifications and de novo protein design, a wide range of customized protein nanocarriers have been created using both natural and synthetic
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Unconventional Catalytic Approaches to Ammonia Synthesis. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Patrick M Barboun,Jason C Hicks
Ammonia is a critically important industrial chemical and is largely responsible for sustaining the growing global population. To provide ammonia to underdeveloped regions and/or regions far from industrial production hubs, modular systems have been targeted and often involve unconventional production methodologies. These novel approaches for ammonia production can tap renewable resources at smaller
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Computational Fluid Dynamics for Fixed Bed Reactor Design. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Anthony G Dixon,Behnam Partopour
Flow, heat, and mass transfer in fixed beds of catalyst particles are complex phenomena and, when combined with catalytic reactions, are multiscale in both time and space; therefore, advanced computational techniques are being applied to fixed bed modeling to an ever-greater extent. The fast-growing literature on the use of computational fluid dynamics (CFD) in fixed bed design reflects the rapid development
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A ChemE Grows in Brooklyn. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-08 Carol K Hall
I profile my personal and professional journey from being a girl of the 1950s, with expectations typical for the times, to a chemical engineering professor and still-enthusiastic researcher. I describe my family, my early education, my college and graduate school training in physics, my postdoc years in chemistry, and my subsequent transformation into a chemical engineering faculty member—one of the
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Introduction. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2020-06-07 Michael Doherty,Rachel Segalman
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Responsive Polymers as Smart Nanomaterials Enable Diverse Applications. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-06-07 Jing Zhao,Victoria E Lee,Rui Liu,Rodney D Priestley
Responsive polymers undergo reversible or irreversible physical or chemical modifications in response to a change in environment or stimulus, e.g., temperature, pH, light, and magnetic or electric fields. Polymeric nanoparticles (NPs), which constitute a diverse set of morphologies, including micelles, vesicles, and core-shell geometries, have been successfully prepared from responsive polymers and
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Perspectives on Low-Temperature Electrolysis and Potential for Renewable Hydrogen at Scale. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-06-07 Katherine Ayers,Nemanja Danilovic,Ryan Ouimet,Marcelo Carmo,Bryan Pivovar,Marius Bornstein
Hydrogen is an important part of any discussion on sustainability and reduction in emissions across major energy sectors. In addition to being a feedstock and process gas for many industrial processes, hydrogen is emerging as a fuel alternative for transportation applications. Renewable sources of hydrogen are therefore required to increase in capacity. Low-temperature electrolysis of water is currently
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Polymer-Based Marine Antifouling and Fouling Release Surfaces: Strategies for Synthesis and Modification. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-06-07 Amanda K Leonardi,Christopher K Ober
In marine industries, the accumulation of organic matter and marine organisms on ship hulls and instruments limits performance, requiring frequent maintenance and increasing fuel costs. Current coatings technology to combat this biofouling relies heavily on the use of toxic, biocide-containing paints. These pose a serious threat to marine ecosystems, affecting both target and nontarget organisms. Innovation
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Nanoparticles for Biomedicine: Coagulation During Synthesis and Applications. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-06-07 Fabian H L Starsich,Inge K Herrmann,Sotiris E Pratsinis
Nanoparticle-based systems offer fascinating possibilities for biomedicine, but their translation into clinics is slow. Missing sterile, reproducible, and scalable methods for their synthesis along with challenges in characterization and poor colloidal stability of nanoparticles in body fluids are key obstacles. Flame aerosol technology gives proven access to scalable synthesis of nanoparticles with
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Electrochemical Conversion of Biomass-Based Oxygenated Compounds. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-06-07 Juliana Carneiro,Eranda Nikolla
Dwindling fossil fuel resources and substantial release of CO2 from their processing have increased the appeal to use biomass as a sustainable platform for synthesis of chemicals and fuels. Steps toward this will require selective upgrading of biomass to suitable intermediates. Traditionally, biomass upgrading has involved thermochemical processes that require excessive amounts of petrochemical-derived
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Glückliche Reise. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-06-07 John M Prausnitz
Following Forest Hills High School in New York City, I attended Cornell University for a five-year program leading to a Bachelor of Chemical Engineering degree. After spending one year at the University of Rochester to obtain a Master of Science in Chemical Engineering, I came to Princeton University in 1951. Four years later, with a fresh PhD, I joined the faculty at the University of California,
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Introduction. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-06-07 Michael Doherty,Rachel Segalman
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Protein and Peptide Biomaterials for Engineered Subunit Vaccines and Immunotherapeutic Applications. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-06-07 Alexandra N Tsoras,Julie A Champion
Although vaccines have been the primary defense against widespread infectious disease for decades, there is a critical need for improvement to combat complex and variable diseases. More control and specificity over the immune response can be achieved by using only subunit components in vaccines. However, these often lack sufficient immunogenicity to fully protect, and conjugation or carrier materials
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Advances in the Use of Microfluidics to Study Crystallization Fundamentals. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-04-24 Nadine Candoni,Romain Grossier,Mehdi Lagaize,Stéphane Veesler
This review compares droplet-based microfluidic systems used to study crystallization fundamentals in chemistry and biology. An original high-throughput droplet-based microfluidic platform is presented. It uses nanoliter droplets, generates a chemical library, and directly solubilizes powder, thus economizing both material and time. It is compatible with all solvents without the need for surfactant
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Colloidal Materials for 3D Printing. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-04-05 Cheng Zhu,Andrew J Pascall,Nikola Dudukovic,Marcus A Worsley,Joshua D Kuntz,Eric B Duoss,Christopher M Spadaccini
In recent years, 3D printing has led to a disruptive manufacturing revolution that allows complex architected materials and structures to be created by directly joining sequential layers into designed 3D components. However, customized feedstocks for specific 3D printing techniques and applications are limited or nonexistent, which greatly impedes the production of desired structural or functional
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Does Chemical Engineering Research Have a Reproducibility Problem? Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-03-27 Rebecca Han,Krista S Walton,David S Sholl
Concerns have been raised in multiple scientific fields in recent years about the reproducibility of published results. Systematic efforts to examine this issue have been undertaken in biomedicine and psychology, but less is known about this important issue in the materials-oriented research that underpins much of modern chemical engineering. Here, we relate a dramatic historical episode from our own
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Toward Sustainable Chemical Engineering: The Role of Process Systems Engineering. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-03-27 Bhavik R Bakshi
Products from chemical engineering are essential for human well-being, but they also contribute to the degradation of ecosystem goods and services that are essential for sustaining all human activities. To contribute to sustainability, chemical engineering needs to address this paradox by developing chemical products and processes that meet the needs of present and future generations. Unintended harm
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On Radical-Induced Ignition in Combustion Systems. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-03-22 Wenkai Liang,Chung K Law
This article reviews recent theoretical developments on incipient ignition induced by radical runaway in systems described by detailed chemistry. Employing eigenvalue analysis, we first analyze the canonical explosion limits of mixtures of hydrogen and oxygen, yielding explicit criteria that well reproduce their characteristic Z-shaped response in the pressure-temperature plot. Subsequently, we evaluate
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Thermodynamic Principles for the Design of Polymers for Drug Formulations. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-03-22 Michael Fischlschweiger,Sabine Enders
Polymers play an essential role in drug formulation and production of medical devices, implants, and diagnostics. Following drug discovery, an appropriate formulation is selected to enable drug delivery. This task can be exceedingly challenging owing to the large number of potential delivery methods and formulation and process variables that can interact in complex ways. This evolving solubility challenge
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Pretreatment Processes of Biomass for Biorefineries: Current Status and Prospects. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-03-20 D Cantero,R Jara,A Navarrete,L Pelaz,J Queiroz,S Rodríguez-Rojo,M J Cocero
This article seeks to be a handy document for the academy and the industry to get quickly up to speed on the current status and prospects of biomass pretreatment for biorefineries. It is divided into two biomass sources: vegetal and animal. Vegetal biomass is the material produced by plants on land or in water (algae), consuming sunlight, CO2, water, and soil nutrients. This includes residues or main
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Modeling Segregation in Granular Flows. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-03-18 Paul B Umbanhowar,Richard M Lueptow,Julio M Ottino
Accurate continuum models of flow and segregation of dense granular flows are now possible. This is the result of extensive comparisons, over the last several years, of computer simulations of increasing accuracy and scale, experiments, and continuum models, in a variety of flows and for a variety of mixtures. Computer simulations-discrete element methods (DEM)-yield remarkably detailed views of granular
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Harnessing Nature's Anaerobes for Biotechnology and Bioprocessing. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-03-18 Igor A Podolsky,Susanna Seppälä,Thomas S Lankiewicz,Jennifer L Brown,Candice L Swift,Michelle A O'Malley
Industrial biotechnology has the potential to decrease our reliance on petroleum for fuel and bio-based chemical production and also enable valorization of waste streams. Anaerobic microorganisms thrive in resource-limited environments and offer an array of novel bioactivities in this regard that could revolutionize biomanufacturing. However, they have not been adopted for widespread industrial use
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Enabling Applications of Covalent Adaptable Networks. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2019-03-18 Matthew K McBride,Brady T Worrell,Tobin Brown,Lewis M Cox,Nancy Sowan,Chen Wang,Maciej Podgorski,Alina M Martinez,Christopher N Bowman
The ability to behave in a fluidlike manner fundamentally separates thermoset and thermoplastic polymers. Bridging this divide, covalent adaptable networks (CANs) structurally resemble thermosets with permanent covalent crosslinks but are able to flow in a manner that resembles thermoplastic behavior only when a dynamic chemical reaction is active. As a consequence, the rheological behavior of CANs
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Introduction. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-06-08 Rachel A Segalman,Michael F Doherty
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The Energy Future. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-06-08 John Newman,Christopher A Bonino,James A Trainham
The foreseeable energy future will be driven by economics of known technologies and the desire to reduce CO2 emissions to the atmosphere. Renewable energy options are compared with each other and with the use of fossil fuels with carbon capture and sequestration (CCS). Economic analysis is used to determine the best of several alternatives. One can disagree on the detailed costs, including externalities
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Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-06-08 Christopher L Burcham,Alastair J Florence,Martin D Johnson
The pharmaceutical industry has found new applications for the use of continuous processing for the manufacture of new therapies currently in development. The transformation has been encouraged by regulatory bodies as well as driven by cost reduction, decreased development cycles, access to new chemistries not practical in batch, improved safety, flexible manufacturing platforms, and improved product
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Molecular Modelling for Reactor Design. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-06-08 Frerich J Keil
Chemical reactor modelling based on insights and data on a molecular level has become reality over the last few years. Multiscale models describing elementary reaction steps and full microkinetic schemes, pore structures, multicomponent adsorption and diffusion inside pores, and entire reactors have been presented. Quantum mechanical (QM) approaches, molecular simulations (Monte Carlo and molecular
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Microkinetic Analysis and Scaling Relations for Catalyst Design. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-04-12 Ali Hussain Motagamwala,Madelyn R Ball,James A Dumesic
Microkinetic analysis plays an important role in catalyst design because it provides insight into the fundamental surface chemistry that controls catalyst performance. In this review, we summarize the development of microkinetic models and the inclusion of scaling relationships in these models. We discuss the importance of achieving stoichiometric and thermodynamic consistency in developing microkinetic
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Advances in Multicompartment Mesoporous Silica Micro/Nanoparticles for Theranostic Applications. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-04-06 Jian Liu,Tingting Liu,Jian Pan,Shaomin Liu,G Q Max Lu
Mesoporous silica nanoparticles (MSNs) are promising functional nanomaterials for a variety of biomedical applications, such as bioimaging, drug/gene delivery, and cancer therapy. This is due to their low density, low toxicity, high biocompatibility, large specific surface areas, and excellent thermal and mechanical stability. The past decade has seen rapid advances in the development of MSNs with
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Nanoscale Optical Microscopy and Spectroscopy Using Near-Field Probes. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-30 Richard J Hermann,Michael J Gordon
Light-matter interactions can provide a wealth of detailed information about the structural, electronic, optical, and chemical properties of materials through various excitation and scattering processes that occur over different length, energy, and timescales. Unfortunately, the wavelike nature of light limits the achievable spatial resolution for interrogation and imaging of materials to roughly λ/2
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Shale Gas Implications for C2-C3 Olefin Production: Incumbent and Future Technology. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-30 Eric E Stangland
Substantial natural gas liquids recovery from tight shale formations has produced a significant boon for the US chemical industry. As fracking technology improves, shale liquids may represent the same for other geographies. As with any major industry disruption, the advent of shale resources permits both the chemical industry and the community an excellent opportunity to have open, foundational discussions
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Engineered Ribosomes for Basic Science and Synthetic Biology. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-29 Anne E d'Aquino,Do Soon Kim,Michael C Jewett
The ribosome is the cell's factory for protein synthesis. With protein synthesis rates of up to 20 amino acids per second and at an accuracy of 99.99%, the extraordinary catalytic capacity of the bacterial translation machinery has attracted extensive efforts to engineer, reconstruct, and repurpose it for biochemical studies and novel functions. Despite these efforts, the potential for harnessing the
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Stable Radical Materials for Energy Applications. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-27 Daniel A Wilcox,Varad Agarkar,Sanjoy Mukherjee,Bryan W Boudouris
Although less studied than their closed-shell counterparts, materials containing stable open-shell chemistries have played a key role in many energy storage and energy conversion devices. In particular, the oxidation-reduction (redox) properties of these stable radicals have made them a substantial contributor to the progress of organic batteries. Moreover, the use of radical-based materials in photovoltaic
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Critical Comparison of Structured Contactors for Adsorption-Based Gas Separations. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-27 Stephen J A DeWitt,Anshuman Sinha,Jayashree Kalyanaraman,Fengyi Zhang,Matthew J Realff,Ryan P Lively
Recent advances in adsorptive gas separations have focused on the development of porous materials with high operating capacity and selectivity, useful parameters that provide early guidance during the development of new materials. Although this material-focused work is necessary to advance the state of the art in adsorption science and engineering, a substantial problem remains: how to integrate these
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Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-27 Johan Karlsson,Hannah J Vaughan,Jordan J Green
Polymeric nanoparticles have tremendous potential to improve the efficacy of therapeutic cancer treatments by facilitating targeted delivery to a desired site. The physical and chemical properties of polymers can be tuned to accomplish delivery across the multiple biological barriers required to reach diverse subsets of cells. The use of biodegradable polymers as nanocarriers is especially attractive
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Biomolecular Ultrasound and Sonogenetics. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-27 David Maresca,Anupama Lakshmanan,Mohamad Abedi,Avinoam Bar-Zion,Arash Farhadi,George J Lu,Jerzy O Szablowski,Di Wu,Sangjin Yoo,Mikhail G Shapiro
Visualizing and modulating molecular and cellular processes occurring deep within living organisms is fundamental to our study of basic biology and disease. Currently, the most sophisticated tools available to dynamically monitor and control cellular events rely on light-responsive proteins, which are difficult to use outside of optically transparent model systems, cultured cells, or surgically accessed
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Single- to Few-Layered, Graphene-Based Separation Membranes. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-24 Fanglei Zhou,Mahdi Fathizadeh,Miao Yu
Two-dimensional, graphene-based materials have attracted great attention as a new membrane building block, primarily owing to their potential to make the thinnest possible membranes and thus provide the highest permeance for effective sieving, assuming comparable porosity to conventional membranes and uniform molecular-sized pores. However, a great challenge exists to fabricate large-area, single-layered
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Crystal Engineering for Catalysis. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-24 Jeffrey D Rimer,Aseem Chawla,Thuy T Le
Crystal engineering relies upon the ability to predictively control intermolecular interactions during the assembly of crystalline materials in a manner that leads to a desired (and predetermined) set of properties. Economics, scalability, and ease of design must be leveraged with techniques that manipulate the thermodynamics and kinetics of crystal nucleation and growth. It is often challenging to
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Confined Flow: Consequences and Implications for Bacteria and Biofilms. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-22 Jacinta C Conrad,Ryan Poling-Skutvik
Bacteria overwhelmingly live in geometrically confined habitats that feature small pores or cavities, narrow channels, or nearby interfaces. Fluid flows through these confined habitats are ubiquitous in both natural and artificial environments colonized by bacteria. Moreover, these flows occur on time and length scales comparable to those associated with motility of bacteria and with the formation
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Toward Constitutive Models for Momentum, Species, and Energy Transport in Gas-Particle Flows. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-20 Sankaran Sundaresan,Ali Ozel,Jari Kolehmainen
As multiscale structures are inherent in multiphase flows, constitutive models employed in conjunction with transport equations for momentum, species, and energy are scale dependent. We suggest that this scale dependency can be better quantified through deep learning techniques and formulation of transport equations for additional quantities such as drift velocity and analogies for species, energy
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From Multiscale to Mesoscience: Addressing Mesoscales in Mesoregimes of Different Levels. Annu. Rev. Chem. Biomol. Eng. (IF 9.561) Pub Date : 2018-03-20 Jinghai Li,Wenlai Huang
This review covers three decades of research on mesoscale phenomena in chemical engineering, from the energy minimization multiscale (EMMS) model specific for gas-solid fluidization to a general principle of compromise in competition between dominant mechanisms, leading to the proposed concept of mesoscience. First, the concept of mesoscales is reviewed with respect to their commonality, diversity