An efficient and practical synthetic approach was developed for the tandem synthesis of trisubstituted 2-pyrone derivatives from sulfoxonium ylides and cyclopropenones. This [3?3] annulation reaction was carried out under transition-metal-free conditions. A broad range of functional groups were tolerant under mild conditions, and a variety of 2-pyrones were obtained in moderate to good yields.

A ruthenium-catalyzed electrochemical dehydrogenative C(sp2) H acyloxylation of aniline derivatives with carboxylic acids has been developed. Electric current is used to recycle the active ruthenium-based catalyst and promote H2 evolution. This method significantly expands the scope and enhances the selectivity of metal-electron catalyzed mono- and di-acyloxylations, which remain challenged. Our findings

Transition-metal-catalyzed direct C¨CH/C¨CH cross-coupling reactions as efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds. However, the strategy for preparation of biphenyl-2-carbonitriles has not been well established. Herein, we described the first cyanogen directed Rh(III)- catalyzed CDC reaction of aromatic nitriles with heteroarenes. Various

Both O-glycosides and nucleosides are essential biomolecules with important roles in a variety of biological processes. Chemical synthesis of both O-glycosides and nucleosides is a scalable and reliable method to develop new therapeutic agents and decipher their functions. However, the efficient synthesis of both O-glycosides and nucleosides remains one of long-standing challenges in chemical synthesis

We present the mechanistic understanding of an electrochemically-driven nickel-catalyzed coupling reaction. Computational analysis reveals that the spin density is mostly residing on the nickel (Ni) center when NiII is reduced to NiI. Ni-mediated halogen atom abstraction through outer-sphere electron-transfer pathway to yield coupling products under mild conditions is demonstrated. Importantly, we

This highlight summarizes a recent development of a catalytic enantioselective Catellani-type reaction for the synthesis of axially chiral biaryls. The chirality induction is solely governed by chiral norbornene ligand in the Pd mediated ortho C¨CH functionalization and ipso cross-coupling transformation. The preparative power of the methodology is demonstrated as a powerful manifold for the divergent