In this paper we present SpikeOnChip, a custom embedded platform for neuronal activity recording and online analysis. The SpikeOnChip platform was developed in the context of automated drug testing and toxicology assessments on neural tissue made from human induced pluripotent stem cells. The system was developed with the following goals: to be small, autonomous and low power, to handle micro-electrode

This work proposed a programmable pulsed radio-frequency (PRF) stimulator for trigeminal neuralgia (TN) relief on demand. The implantable stimulator is a miniaturized micro-system which integrates a wireless interface circuit, a sensor interface circuit, a PRF pattern generation circuit and a logic controller. The multifunctional stimulator capable of delivering current/voltage stimulation provides

Emerging non-imaging ultrasound applications, such as ultrasonic wireless power delivery to implantable devices and ultrasound neuromodulation, require wearable form factors, millisecond-range pulse durations and focal spot diameters approaching 100 m with electronic control of its three-dimensional location. None of these are compatible with typical handheld linear array ultrasound imaging probes

Recently, an electrical stimulation of the paralyzed muscle, as a potential therapy for restoring function of a denervated muscle system, has been debated as an innovative treatment in the management of patients with laryngeal paralysis. Numerous studies in acute and chronic animal models have demonstrated that electrical stimulation of the paralyzed posterior cricoarytenoideus muscle (PCA) offers

This study presents a prototype noninvasive, miniaturized transcutaneous oxygen monitor using the luminescent sensing technique. We implemented this design on a printed circuit board with off-the-shelf components. We conducted experiments to understand the temperature and humidity dependence of oxygen-sensitive platinum-porphyrin films. We performed a detailed analysis of both intensity and lifetime

This paper describes a simple and reproducible methodology for universal evaluation of the performance of electrical impedance tomography (EIT) systems using reconstructed images. Based on objective full referencing (FR), the method provides a visually distinguishable hot colormap and two new FR metrics, the global and the more specific region of interest, to address the issues where common electrical

In this paper, a combined pH and impedance sensing system suitable for portable measurements is presented. The sensor outputs are converted directly to frequency or pulse width. The pH sensor is based on a voltage clamp topology that uses charging and discharging capacitors, voltage window compara- tors, and an SR-Latch to convert the output to frequency. The impedance to frequency sensor is based

ESR1 mutations are important biomarkers in metastatic breast cancer. Specifically, p.E380Q and p.Y537S mu- tations arise in response to hormonal therapies given to patients with hormone receptor positive (HR+) breast cancer (BC). This paper demonstrates the efficacy of an ISFET based CMOS integrated Lab-on-Chip (LoC) system, coupled with variant- specific isothermal amplification chemistries, for detection

In this work, we propose a current-mode dielectric spectroscopy integrated circuit (IC) for the detection of liquids permittivity at microwave frequency range. The current-mode sensing scheme presents wideband operation with enhanced dynamic range compared to conventional voltage-mode sensing approach. A low intermediate frequency (IF) receiver architecture further provides better performances in flicker

An energy-efficient electrocardiogram (ECG) processor for real-time QRS detection is presented. The proposed algorithm is based on the Pan-Tompkins algorithm and it is implemented in the analog domain leveraging ultra-low power analog electronics biased in subthreshold. Operational transconductance amplifiers with ~100 mV linear range are used in almost all of the processing blocks, while squaring

Epilepsy is a common clinical disease. Severe epilepsy can be life-threatening in certain unexpected conditions, so it is important to detect seizures instantly with a wearable device and to provide treatment within the golden window. The observation of the electroencephalography (EEG) signal is an imperative method to assist correct epilepsy diagnosis. To detect and classify EEG signals, a convolutional

Photoacoustic (PA) imaging is becoming more attractive because it can obtain high-resolution and high-contrast images through merging the merits of optical and acoustic imaging. High sensitivity receiver is required in deep in-vivo PA imaging due to detecting weak and noisy ultrasound signal. A novel photoacoustic receiver system-on-chip (SoC) with coherent detection (CD) based on the early-and-late

In this paper, reduced deep convolutional stack autoencoder (RDCSAE) and improved kernel random vector functional link network (IKRVFLN) are combined to recognize the epileptic seizure using both the multichannel scalp and single-channel electroencephalogram (EEG) signals. The novel RDCSAE structure is designed to extract the most discriminative unsupervised features from EEG signals and fed into the

Most memristor-based neural networks only consider a single mode of memory or emotion, but ignore the relationship between emotion and memory. In this paper, a memristor-based neural network circuit of emotion congruent memory is proposed and verified by the simulation results. The designed circuit consists of a memory module, an emotion module and an association neuron module. Varieties of memory

Recent years have witnessed a growing interest in EEG-based wearable classifiers of emotions, which could enable the real-time monitoring of patients suffering from neurological disorders such as Amyotrophic Lateral Sclerosis (ALS), Autism Spectrum Disorder (ASD), or Alzheimer's. The hope is that such wearable emotion classifiers would facilitate the patients' social integration and lead to improved

Hypoxia refers to insufficient oxygen amounts at the tissue level unable to maintain adequate homeostasis. And severe hypoxia may occur in the absence of subjective breathlessness due to drastic respiratory failure. Catering to clinical requirements, precise monitoring of low blood oxygen saturation is crucially desired. However, the current pulse oximeters cannot function well in monitoring peripheral

This work presents a portable wireless urine detection system which consists of an electrochemical readout application specific integrated circuit (ASIC) and a biosensor composed of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and carbon nanotube (ABTS-CNT) for the detection of urine albumin-to-creatinine ratio (UACR). The ASIC includes a potentiostat, a digital circuitry and a power management

A 16-channel monopolar biphasic stimulator chip with discharge function for biomedical applications is proposed and designed. To provide monopolar biphasic stimulus currents, the positive (6V) and the negative (-6V) voltage sources are supported to generate the desired current pulses of ±3 mA. The monopolar biphasic stimulator chip was fabricated in a 0.18-m 1.8-V/3.3-V CMOS process with the common

This paper presents a compact DDA-based fully-differential CMOS instrumentation amplifier dedicated for micro-power ECG monitoring. Only eight transistors are employed to realize a power-efficient current-sharing DDA. A RC network (using MOS pseudo resistors and poly capacitors) forms feedback loops around the DDA creating an ac-only amplification. The proposed amplifier is dc-coupled via gate terminals

A wearable textile brace is introduced as an electromagnetic imaging system that breaks hospital boundaries to real-time onsite scanning for knee injuries. The proposed brace consists of a 12-element textile slot loop antenna array, which is designed to match the human knee for enhanced electromagnetic wave penetration. Wool felt and conductive fabric are used to fabricate the antenna array thanks

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The paper presents a 256-pixel CMOS sensor array with in-pixel dual electrochemical and impedance detection modalities for rapid, multi-dimensional characterization of exoelectrogens. The CMOS IC has 16 parallel readout channels, allowing it to perform multiple measurements with a high throughput and enable the chip to handle different samples simultaneously. The chip contains a total of 2 × 256 working

High-Intensity Focused Ultrasound (HIFU) therapy provides a non-invasive technique with which to destroy cancerous tissue without using ionizing radiation. To drive large single-element High-Intensity Focused Ultrasound (HIFU) transducers, ultrasound transmitters capable of delivering high powers at relevant frequencies are required. The acoustic power delivered to a transducers focal region will determine

Continuous monitoring of anaesthetics infusion is demanded by anaesthesiologists to help in defining personalized dose, hence reducing risks and side effects. We propose the first piece of technology tailored explicitly to close the loop between anaesthesiologist and patient with continuous drug monitoring. Direct detection of drugs is achieved with electrochemical techniques, and several options are

In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and µLEDs enable the detection and control of neural activity using a single implanted device. Miniaturized solutions for recordings from small freely moving animals are commercially available, but stimulation is driven by large, stationary

This paper studies the performance of a resonant capacitive wireless power transfer (C-WPT) link for biomedical implants in the presence of non-idealities. The study emphasizes on finding an accurate electrical model of a practical C-WPT link, which can be used to investigate the performance of the link under different practical/non-ideal scenarios. A sound knowledge about these non-idealities is crucial

Plantar cutaneous feedback plays an important role in stable and efficient gait, by modulating the activity of ankle dorsi- and plantar-flexor muscles. However, central and peripheral nervous system trauma often decrease plantar cutaneous feedback and/or interneuronal excitability in processing the plantar cutaneous feedback. In this study, we tested a fully implantable neural recording and stimulation

This paper presents a new fully integrated CMOS capacitance sensor chip with a wider input dynamic range (IDR) compared to the state-of-the-art, suitable for a variety of life science applications. With the novel differential capacitance to current conversion topology, it achieves an IDR of about seven times higher compared to the previous charge based capacitive measurement (CBCM) circuits and about

Implantable brain machine interfaces for treatment of neurological disorders require on-chip, real-time signal processing of action potentials (spikes). In this work, we present the first spike sorting SoC with integrated neural recording front-end and analog unsupervised classifier. The event-driven, low power spike sorter features a novel hardware-optimized, K-means based algorithm that effectively

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Both bacterial viability and concentration are significant metrics for bacterial detection. Existing miniaturized and cost-effective single-mode sensor, pH or optical, can only be skilled at detecting single information viability or concentration. This paper presents an inverter-based CMOS ion-sensitive-field-effect-transistor (ISFET) sensor array, featuring bacterial pH detection which is an indicator

An ultra-low power low noise analog front end (AFE) is presented in this work, aiming for long-term ECG with clear P-waves for clinical diagnose. The proposed AFE achieves a noise-efficient-factor (NEF) of 2.4 and an input-referred noise of 0.39 Vrms in the best case, which shows 3.7X noise improvements among the state-of-the-art designs. The chopper amplifier applies embedded passive high-pass filters

We present a CMOS biochip-based photometer for quantitative immunoassay diagnostics. The photometer quantifies the concentration of antigens based on light absorption, which allows for a low-cost implementation without expensive optical components. We propose a light controller to lower the start-up and settling time of the light source to 30 seconds, to facilitate fast measurement starts, and to decrease

In this paper, a fully integrated active rectifier with triple feedback loops is proposed to enhance power conversion efficiency (PCE) over a wide loading range by calibrating both the gate transition timing and power switch size. The on- and off-transitions of the power switches are calibrated using a hybrid delay-based gate control circuit (HDGCC) with hybrid feedback loops. Conventional active rectifiers

A high-pass sigmadelta modulator (HPSDM) is proposed for electrocardiography (ECG) signal acquisition system. The HPSDM is implemented using operational amplifier (op-amp) sharing and programmable feedforward coefficients. The op-amp sharing is adopted to reduce the quantity of amplifiers because they dominate the power consumption of the HPSDM. In addition, given that the magnitude of the ECG is dependent

Modern neuromodulation systems typically provide a large number of recording and stimulation channels, which reduces the available power and area budget per channel. To maintain the necessary input-referred noise performance despite growingly rigorous area constraints, chopped neural front-ends are often the modality of choice, as chopperstabilization allows to simultaneously improve (1/f) noise and

Ultrasound open platforms are programmable and flexible tools for the development and test of novel methods. In most cases, they embed the electronics for the independent control of (maximum) 256 probe elements. However, a higher number of channels is needed for the control of 2-D array probes. This paper presents a system architecture that, through the hardware and software synchronization of multiple

Ultrasound open platforms are programmable and flexible tools for the development and test of novel methods. In most cases, they embed the electronics for the independent control of (maximum) 256 probe elements. However, a higher number of channels is needed for the control of 2-D array probes. This paper presents a system architecture that, through the hardware and software synchronization of multiple

This paper presents a new fully integrated CMOS capacitance sensor chip with a wider input dynamic range compared to the state-of-the-art, suitable for a variety of life science applications. With the novel differential capacitance to current conversion topology, it achieves an IDR of about seven times higher compared to previous charge based capacitive measurement circuits and more than three times

For precise health status monitoring and disease diagnostics in the current COVID-19 pandemic, it is essential to detect various kinds of target signals robustly under high noise and strong interferences. Moreover, the health monitoring system is preferred to be realized in a small form factor for convenient mass deployments. A CMOS-integrated coherent sensing platform is proposed to achieve the goal

For precise health status monitoring and disease diagnostics in the current COVID-19 pandemic, it is essential to detect various kinds of target signals robustly under high noise and strong interferences. Moreover, the health monitoring system is preferred to be realized in a small form factor for convenient mass deployments. A CMOS-integrated coherent sensing platform is proposed to achieve the goal

Plantar cutaneous feedback plays an important role in stable and efficient gait, by modulating the activity of ankle dorsi-and plantar-flexor muscles. However, central and peripheral nervous trauma often decrease plantar cutaneous feedback and/or interneuronal excitability in processing the plantar cutaneous feedback. In this study, we tested if a fully implantable neural recording and stimulation

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A person's behavior significantly influences their health and well-being. It also contributes to the social environment in which humans interact, with cascading impacts to the health and behaviors of others. During social interactions, our understanding and awareness of vital nonverbal messages expressing beliefs, emotions, and intentions can be obstructed by a variety of factors including greatly

Sleep posture, as a crucial index for sleep quality assessment, has been widely studied in sleep analysis. In this paper, an unobtrusive smart mat system based on a dense flexible sensor array and printed electrodes along with an algorithmic framework for sleep posture recognition is proposed. With the dense flexible sensor array, the system offers a comfortable and high-resolution solution for long-term

A real-time and label-free microstrip sensor capable of detecting and monitoring subsurface growth of Escherichia coli ( E. coli ) on solid growth media such as Luria-Bertani (LB) agar is presented. The microwave ring resonator was designed to operate at 1.76 GHz to detect variations in the dielectric properties such as permittivity and loss tangent to monitor bacterial growth. The sensor demonstrated

This paper presents a low cost, noninvasive, clinical-grade Pulse Wave Velocity evaluation device. The proposed system relies on a simultaneous acquisition of femoral and carotid pulse waves to improve estimation accuracy and correctness. The sensors used are two high precision MEMS force sensors, encapsulated in two ergonomic probes, and connected to the main unit. Data are then wirelessly transmitted

Cardiovascular disease (CVD) threatens the lives of many and affects their productivity. Wearable sensors can enable continuous monitoring of hemodynamic parameters to improve the diagnosis and management of CVD. Bio-Impedance (Bio-Z) is an effective non-invasive sensor for arterial pulse wave monitoring based on blood volume changes in the artery due to the deep penetration of its current signal inside

Wireless power coils have found important use in implantable medical devices for safe and reliable wireless power transfer. Designing coils for each specific application is a complex process with many interdependent design variables; determining the most optimal design parameters for each pair is challenging and time-consuming. In this paper, we develop an automated design method for planar square-spiral

Point-of-care testing (POCT) is characterized by fast detection, simple use, and cost efficiency. As the focus of healthcare shifts to precision medicine, population health, and chronic disease management, the potential impact of POCT has increased significantly in the past decade. Immunochromatographic test strips (ICTSs) are currently the most promising POCT diagnostic format due to the advantages

Size and absolute concentration of suspensions of nanoparticles are important information for the study and development of new materials and products in different industrial applications spanning from biotechnology and pharmaceutics to food preparation and conservation. Laser Transmission Spectroscopy (LTS) is the only methodology able to measure nanoparticle size and concentration by performing a

Prospective authors are requested to submit new, unpublished manuscripts for inclusion in the upcoming event described in this call for papers.

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In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and μLEDs enable the detection and control of neural activity using a single implanted device. Miniaturized solutions for recordings from small freely moving animals are commercially available, but stimulation is driven by large, stationary

Implantable motor neuroprostheses can restore functionality to individuals with neurological disabilities by electrically activating paralyzed muscles in coordinated patterns. The typical design of neuroprosthetic systems relies on a single multi-use device, but this limits the number of stimulus and sensor channels that can be practically implemented. To address this limitation, a modular neuroprosthesis

Obstructive sleep apnea (OSA), as a highly prevalent sleep disorder, causes several serious health complaints. It has been proved that using intraoral mandibular advancement devices (MADs) during sleep is an efficient treatment for OSA. However, due to limited number of sleep study laboratories, effectiveness of MAD therapy is not regularly monitored. This paper proposes a smart MAD with the capability