Ultrasound open platforms are programmable and flexible tools for the development and test of novel methods. In most cases, they embed the electronics for the independent control of (maximum) 256 probe elements. However, a higher number of channels is needed for the control of 2-D array probes. This paper presents a system architecture that, through the hardware and software synchronization of multiple

Ultrasound open platforms are programmable and flexible tools for the development and test of novel methods. In most cases, they embed the electronics for the independent control of (maximum) 256 probe elements. However, a higher number of channels is needed for the control of 2-D array probes. This paper presents a system architecture that, through the hardware and software synchronization of multiple

Implantable brain machine interfaces for treatment of neurological disorders require on-chip, real-time signal processing of action potentials (spikes). In this work, we present the first spike sorting SoC with integrated neural recording front-end and analog unsupervised classifier. The event-driven, low power spike sorter features a novel hardware-optimized, K-means based algorithm that effectively

This paper presents a new fully integrated CMOS capacitance sensor chip with a wider input dynamic range compared to the state-of-the-art, suitable for a variety of life science applications. With the novel differential capacitance to current conversion topology, it achieves an IDR of about seven times higher compared to previous charge based capacitive measurement circuits and more than three times

This paper presents a new fully integrated CMOS capacitance sensor chip with a wider input dynamic range compared to the state-of-the-art, suitable for a variety of life science applications. With the novel differential capacitance to current conversion topology, it achieves an IDR of about seven times higher compared to previous charge based capacitive measurement circuits and more than three times

For precise health status monitoring and disease diagnostics in the current COVID-19 pandemic, it is essential to detect various kinds of target signals robustly under high noise and strong interferences. Moreover, the health monitoring system is preferred to be realized in a small form factor for convenient mass deployments. A CMOS-integrated coherent sensing platform is proposed to achieve the goal

For precise health status monitoring and disease diagnostics in the current COVID-19 pandemic, it is essential to detect various kinds of target signals robustly under high noise and strong interferences. Moreover, the health monitoring system is preferred to be realized in a small form factor for convenient mass deployments. A CMOS-integrated coherent sensing platform is proposed to achieve the goal

Plantar cutaneous feedback plays an important role in stable and efficient gait, by modulating the activity of ankle dorsi-and plantar-flexor muscles. However, central and peripheral nervous trauma often decrease plantar cutaneous feedback and/or interneuronal excitability in processing the plantar cutaneous feedback. In this study, we tested if a fully implantable neural recording and stimulation

Plantar cutaneous feedback plays an important role in stable and efficient gait, by modulating the activity of ankle dorsi-and plantar-flexor muscles. However, central and peripheral nervous trauma often decrease plantar cutaneous feedback and/or interneuronal excitability in processing the plantar cutaneous feedback. In this study, we tested if a fully implantable neural recording and stimulation

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A person's behavior significantly influences their health and well-being. It also contributes to the social environment in which humans interact, with cascading impacts to the health and behaviors of others. During social interactions, our understanding and awareness of vital nonverbal messages expressing beliefs, emotions, and intentions can be obstructed by a variety of factors including greatly

Sleep posture, as a crucial index for sleep quality assessment, has been widely studied in sleep analysis. In this paper, an unobtrusive smart mat system based on a dense flexible sensor array and printed electrodes along with an algorithmic framework for sleep posture recognition is proposed. With the dense flexible sensor array, the system offers a comfortable and high-resolution solution for long-term

A real-time and label-free microstrip sensor capable of detecting and monitoring subsurface growth of Escherichia coli ( E. coli ) on solid growth media such as Luria-Bertani (LB) agar is presented. The microwave ring resonator was designed to operate at 1.76 GHz to detect variations in the dielectric properties such as permittivity and loss tangent to monitor bacterial growth. The sensor demonstrated

This paper presents a low cost, noninvasive, clinical-grade Pulse Wave Velocity evaluation device. The proposed system relies on a simultaneous acquisition of femoral and carotid pulse waves to improve estimation accuracy and correctness. The sensors used are two high precision MEMS force sensors, encapsulated in two ergonomic probes, and connected to the main unit. Data are then wirelessly transmitted

Cardiovascular disease (CVD) threatens the lives of many and affects their productivity. Wearable sensors can enable continuous monitoring of hemodynamic parameters to improve the diagnosis and management of CVD. Bio-Impedance (Bio-Z) is an effective non-invasive sensor for arterial pulse wave monitoring based on blood volume changes in the artery due to the deep penetration of its current signal inside

Wireless power coils have found important use in implantable medical devices for safe and reliable wireless power transfer. Designing coils for each specific application is a complex process with many interdependent design variables; determining the most optimal design parameters for each pair is challenging and time-consuming. In this paper, we develop an automated design method for planar square-spiral

Point-of-care testing (POCT) is characterized by fast detection, simple use, and cost efficiency. As the focus of healthcare shifts to precision medicine, population health, and chronic disease management, the potential impact of POCT has increased significantly in the past decade. Immunochromatographic test strips (ICTSs) are currently the most promising POCT diagnostic format due to the advantages

Size and absolute concentration of suspensions of nanoparticles are important information for the study and development of new materials and products in different industrial applications spanning from biotechnology and pharmaceutics to food preparation and conservation. Laser Transmission Spectroscopy (LTS) is the only methodology able to measure nanoparticle size and concentration by performing a

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Advertisement, IEEE. IEEE Collabratec is a new, integrated online community where IEEE members, researchers, authors, and technology professionals with similar fields of interest can network and collaborate, as well as create and manage content. Featuring a suite of powerful online networking and collaboration tools, IEEE Collabratec allows you to connect according to geographic location, technical

This paper studies the performance of a resonant capacitive wireless power transfer (C-WPT) link for biomedical implants in the presence of non-idealities. The study emphasizes on finding an accurate electrical model of a practical C-WPT link, which can be used to investigate the performance of the link under different practical/non-ideal scenarios. A sound knowledge about these non-idealities is crucial

In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and μLEDs enable the detection and control of neural activity using a single implanted device. Miniaturized solutions for recordings from small freely moving animals are commercially available, but stimulation is driven by large, stationary

In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and μLEDs enable the detection and control of neural activity using a single implanted device. Miniaturized solutions for recordings from small freely moving animals are commercially available, but stimulation is driven by large, stationary

The paper presents a 256-pixel CMOS sensor array with in-pixel dual electrochemical and impedance detection modalities for rapid, multi-dimensional characterization of exoelectrogens. The CMOS IC has 16 parallel readout channels, allowing it to perform multiple measurements with a high throughput and enable the chip to handle different samples simultaneously. The chip contains a total of 2256 working

High-Intensity Focused Ultrasound (HIFU) therapy provides a non-invasive technique with which to destroy cancerous tissue without using ionizing radiation. To drive large single-element HIFU transducers, ultrasound transmitters capable of delivering high powers at relevant frequencies are required. The acoustic power delivered to a transducers focal region will determine the treated area, and due to

Continuous monitoring of anaesthetics infusion is demanded by anaesthesiologists to help in defining personalized dose, hence reducing risks and side effects. We propose the first piece of technology tailored explicitly to close the loop between anaesthesiologist and patient with continuous drug monitoring. Direct detection of drugs is achieved with electrochemical techniques, and several options are

Implantable motor neuroprostheses can restore functionality to individuals with neurological disabilities by electrically activating paralyzed muscles in coordinated patterns. The typical design of neuroprosthetic systems relies on a single multi-use device, but this limits the number of stimulus and sensors channels that can be practically implemented. To address this limitation, a modular neuroprosthesis

Obstructive sleep apnea (OSA), as a highly prevalent sleep disorder, causes several serious health complaints. It has been proved that using intraoral mandibular advancement devices (MADs) during sleep is an efficient treatment for OSA. However, due to limited number of sleep study laboratories, effectiveness of MAD therapy is not regularly monitored. This paper proposes a smart MAD with the capability

Obstructive sleep apnea (OSA), as a highly prevalent sleep disorder, causes several serious health complaints. It has been proved that using intraoral mandibular advancement devices (MADs) during sleep is an efficient treatment for OSA. However, due to limited number of sleep study laboratories, effectiveness of MAD therapy is not regularly monitored. This paper proposes a smart MAD with the capability

Due to the movement expressiveness and privacy assurance of human skeleton data, 3D skeleton-based action inference is becoming popular in healthcare applications. These scenarios call for more advanced performance in application-specific algorithms and efficient hardware support. Warnings on health emergencies sensitive to response speed require low latency output and action early detection capabilities

This paper studies the fundamental trade-off between power transfer efficiency (PTE) and spectral efficiency for simultaneous power and data transfer through near-field inductive links. A mathematical analysis is used to establish the relationship between PTE and channel capacity as a function of link parameters such as coupling coefficient (k), load resistance, and surrounding environment. The analysis

This paper studies the fundamental trade-off between power transfer efficiency (PTE) and spectral efficiency for simultaneous power and data transfer through near-field inductive links. A mathematical analysis is used to establish the relationship between PTE and channel capacity as a function of link parameters such as coupling coefficient (k), load resistance, and surrounding environment. The analysis

The recording of biopotential signals using techniques such as electroencephalography (EEG) and electrocardiography (ECG) poses important challenges to the design of the front-end readout circuits in terms of noise, electrode DC offset cancellation and motion artifact tolerance. In this paper, we present a 2nd-order hybrid-CTDT - modulator front-end architecture that tackles these challenges by taking

In this work, ISFET frontends utilising the direct tunneling current to eliminate trapped charge are proposed. The principle has been investigated and verified via silicon-imitated ISFET first, where silicon capacitors are used to imitate the passivation ones. Because the dominant tunneling components depend on the potential difference between Gate and Drain terminals, a source-follower structure could

In this work, ISFET frontends utilising the direct tunneling current to eliminate trapped charge are proposed. The principle has been investigated and verified via silicon-imitated ISFET first, where silicon capacitors are used to imitate the passivation ones. Because the dominant tunneling components depend on the potential difference between Gate and Drain terminals, a source-follower structure could

A cyclic voltammetry electrochemical sensing chip was implemented with a time-based readout circuit and a current feedback control loop for wide-range and high-linearity current detection. The design utilizes a chopper-stabilized, low-noise potentiostat circuit and a delay chain time-to-digital converter to improve accuracy and the conversion rate. A current feedback loop is employed to mitigate nonlinearity

A cyclic voltammetry electrochemical sensing chip was implemented with a time-based readout circuit and a current feedback control loop for wide-range and high-linearity current detection. The design utilizes a chopper-stabilized, low-noise potentiostat circuit and a delay chain time-to-digital converter to improve accuracy and the conversion rate. A current feedback loop is employed to mitigate nonlinearity

Implant failure can have devastating consequences on patient outcomes following joint replacement. Time to diagnosis affects subsequent treatment success, but current diagnostics do not give early warning and lack accuracy. This research proposes an embedded ultrasound system to monitor implant fixation and temperature – a potential indicator of infection. Requiring only two implanted components: a

As most of the bio-molecules sizes are comparable to the terahertz (THz) wavelength, this frequency range has spurred great attention for bio-medical and bio-sensing applications. Utilizing such capabilities of THz electromagnetic wave, this paper presents the design and analysis of a new non-intrusive and label-free THz bio-sensor for aqueous bio-samples using the microfluidic approach with real-time

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The advent of dedicated Deep Learning (DL) accelerators and neuromorphic processors has brought on new opportunities for applying both Deep and Spiking Neural Network (SNN) algorithms to healthcare and biomedical applications at the edge. This can facilitate the advancement of medical Internet of Things (IoT) systems and Point of Care (PoC) devices. In this paper, we provide a tutorial describing how

In neurostimulation, wireless power transfer is an efficient technology to overcome several limitations affecting medical devices currently used in clinical practice. Several methods were developed over the years for wireless power transfer. In this review article, we report and discuss the three most relevant methodologies for extremely miniaturised implantable neurostimulators: ultrasound coupling

The eight papers in this special section were presented at the IEEE International Solid-State Circuits Conference (ISSCC)that was held in San Francisco, California, from February 16 to February 20, 2020.

This paper reports on a low-power readout IC (ROIC) for high-fidelity recording of the photoplethysmogram (PPG) signal. The system comprises a highly reconfigurable, continuous-time, second-order, incremental delta-sigma modulator (I–ΔΣM) as a light-to-digital converter (LDC), a 2-channel 10b light-emitting diode (LED) driver, and an integrated digital signal processing (DSP) unit. The LDC operation

This paper presents a reconfigurable, dual-output, regulating rectifier featuring pulse width modulation (PWM) and dual-mode pulse frequency modulation (PFM) control schemes for single-stage ac-to-dc conversion to provide two independently regulated supply voltages (each in 1.5–3 V) from an input ac voltage. The dual-mode PFM controllers feature event-driven regulation as well as frequency division

A wireless and battery-less trimodal neural interface system-on-chip (SoC), capable of 16-ch neural recording, 8-ch electrical stimulation, and 16-ch optical stimulation, all integrated on a 5 × 3 mm 2 chip fabricated in 0.35-μm standard CMOS process. The trimodal SoC is designed to be inductively powered and communicated. The downlink data telemetry utilizes on–off keying pulse-position modulation

This paper presents a millimeter-scale crystal-less wireless transceiver for volume-constrained insertable pills. Operating in the 402–405 MHz medical implant communication service (MICS) band, the phase-tracking receiver-based over-the-air carrier recovery has a ±160 ppm coverage. A fully integrated adaptive antenna impedance matching solution is proposed to calibrate the antenna impedance variation

A 1225-Channel Neuromorphic Retinal Prosthesis (RP) SoC is presented. Existing RP SoCs directly convert light intensity to electrical stimulus, which limit the adoption of delicate stimulus patterns to increase visual acuity. Moreover, a conventional centralized image processor leads to the local hot spot that poses a risk to the nearby retinal cells. To solve these issues, the proposed SoC adopts

This paper presents the first wireless and programmable neural stimulator leveraging magnetoelectric (ME) effects for power and data transfer. Thanks to low tissue absorption, low misalignment sensitivity and high power transfer efficiency, the ME effect enables safe delivery of high power levels (a few milliwatts) at low resonant frequencies ( $\sim$ 250 kHz) to mm-sized implants deep inside the body

This paper presents a wearable active concentric electrode for concurrent EEG monitoring and Body-Coupled Communication (BCC) data transmission. A three-layer concentric electrode eliminates the usage of wires. A common mode averaging unit (CMAU) is proposed to cancel not only the continuous common-mode interference (CMI) but also the instantaneous CMI of up to 51V pp . The localized potential matching

This paper presents the body-coupled power transmission and ambient energy harvesting ICs. The ICs utilize human body-coupling to deliver power to the entire body, and at the same time, harvest energy from ambient EM waves coupled through the body. The ICs improve the recovered power level by adapting to the varying skin-electrode interface parasitic impedance at both the TX and RX. To maximize the

Ultrasonic backscatter communication has gained popularity in recent years with the advent of deep-tissue sub-mm scale biosensing implants in which piezoceramic (piezo) resonators are used as acoustic antennas. Miniaturization is a key design goal for such implants to reduce tissue displacement and enable minimally invasive implantation techniques. Here, we provide a systematic design approach for

In recent years, electroceuticals have been spotlighted as an emerging treatment for various severe chronic brain diseases, owing to their intrinsic advantage of electrical interaction with the brain, which is the most electrically active organ. However, the majority of research has verified only the short-term efficacy through acute studies in laboratory tests owing to the lack of a reliable miniaturized

Planar microwave sensors are considered an attractive choice to noninvasively probe the dielectric attributes of biological tissues due to their low cost, simple fabrication, miniature scale, and minimum risk to human health. This paper develops and measures a novel microwave biosensor for non-invasive real-time monitoring of glucose level. The design comprises a rectangular plexiglass channel integrated

A bio-potential recorder working under 0.8 V supply voltage with a tunable low-pass filter is proposed in this paper. The prototype is implemented in TSMC 180 nm CMOS technology, featuring a power consumption of 2.27 $\mu$ W, while preserving a high tolerance of power-line interference (PLI) up to 600 m $V_{pp}$ , a common-mode rejection ratio (CMRR) of higher than 100 dB, a THD of −65.5 dB, and a

A flexible, multifunctional, and intelligent analgesic bracelet was proposed in this article to alleviate symptoms of pain. Based on the theory of wrist-ankle acupuncture in traditional Chinese medicine, transcutaneous electrical nerve stimulation is the technical basis of the method. A set of targeted circuit system capable of generating adjustable electrical stimulation signals to simulate filamentary

Corrections were made to the title in the above named paper.