Abstract Background Many elderly people suffer from chronic health conditions and mobility limitations. Therefore, they may benefit from traditional rehabilitation or telerehabilitation interventions as an alternative for this type of services. Objective The purpose of this study was to compare the effectiveness of telerehabilitation interventions with traditional rehabilitation services for therapeutic

Abstract Background FAIR (findability, accessibility, interoperability, and reusability) guiding principles seek the reuse of data and other digital research input, output, and objects (algorithms, tools, and workflows that led to that data) making them findable, accessible, interoperable, and reusable. GO FAIR - a bottom-up, stakeholder driven and self-governed initiative - defined a seven-step FAIRification

Abstract Background Due to the ongoing increase and importance of the sustainable reusability of data, the findable, accessible, interoperable, reusable or FAIR principles were developed which are also relevant in translational research. Objectives The study aims at identification of platforms by literature search that are suitable for implementation in translational research, in particular with regard

Abstract Background Against the background of a steadily increasing degree of digitalization in health care, a professional information management (IM) is required to successfully plan, implement, and evaluate information technology (IT). At its core, IM has to ensure a high quality of health data and health information systems to support patient care. Objectives The goal of the present study was to

Abstract Unsupervised home exercise is a major component of physical therapy (PT). This study proposes an inexpensive, inertial measurement unit-based wearable device to capture kinematic data to facilitate exercise. However, conveying and interpreting kinematic data to non-experts poses a challenge due to the complexity and background knowledge required that most patients lack. Objectives The objectives

Abstract Background There is a recognized need to improve how scholarly data are managed and accessed. The scientific community has proposed the findable, accessible, interoperable, and reusable (FAIR) data principles to address this issue. Objective The objective of this case study was to develop a system for improving the FAIRness of Healthcare Cost and Utilization Project's State Emergency Department

Abstract Background The Asbest chrysotile cohort was set up in Asbest town, Sverdlovsk oblast, Russian Federation, among the current and former workforce of the world's largest operating chrysotile mine and its processing mills, to investigate cancer risk in relation to occupational exposure to chrysotile. Objectives The cohort of 35,837 people was followed-up for mortality using cause-of-death information

Abstract Background Although advances in prediction accuracy have been made with new machine learning methods, such as support vector machines and deep neural networks, these methods make nonlinear machine learning models and thus lack the ability to explain the basis of their predictions. Improving their explanatory capabilities would increase the reliability of their predictions. Objective Our objective

It was with great interest that I read the recent article by Al-Rayes et al. Within the authors' institution, not all inpatient physicians have adopted a recently implemented electronic health record (EHR) system. This pilot cross-sectional quantitative study investigated the factors limiting adoption of EHR systems among physicians at King Fahd Military Medical Complex in Saudi Arabia. Using the theoretical

Abstract Background Managing research data in biomedical informatics research requires solid data governance rules to guarantee sustainable operation, as it generally involves several professions and multiple sites. As every discipline involved in biomedical research applies its own set of tools and methods, research data as well as applied methods tend to branch out into numerous intermediate and

Abstract Objectives The current study sought to evaluate whether nursing narratives can be used to predict postoperative length of hospital stay (LOS) following curative surgery for ovarian cancer. Methods A total of 33 patients, aged over 65 years, underwent curative surgery for newly diagnosed ovarian cancer between 2008 and 2012. Based on the median postoperative LOS, patients were divided into

Abstract Objectives This article aims to determine possible improvements made by feature extraction methods to the machine learning prediction methods for predicting 30-day hospital readmissions. Methods The study evaluates five feature extraction methods including principal component analysis (PCA), kernel principal component analysis (KPCA), isomap, Laplacian eigenmaps, and locality preserving projections

Abstract Background The acute graft-versus-host disease (aGvHD) is the most important cause of mortality in patients receiving allogeneic hematopoietic stem cell transplantation. Given that it occurs at the stage of severe tissue damage, its diagnosis is late. With the advancement of machine learning (ML), promising real-time models to predict aGvHD have emerged. Objective This article aims to synthesize

Abstract Background Development of ontologies in traditional medicine can be a foundation for other applications of informatics in this field. Despite the importance of the development of ontologies in traditional medicine, there are few review studies in this area. This study aims to review different methods for ontology development and evaluation in traditional medicine. Methods This review study

Abstract Background Health dialog systems have seen increased adoption by patients, hospitals, and universities due to the confluence of advancements in machine learning and the ubiquity of high-performance hardware that supports real-time speech recognition, high-fidelity text-to-speech, and semantic understanding of natural language. Objectives This review seeks to enumerate opportunities to apply

We are enormously saddened by the death of our friend and colleague, Donald A.B. Lindberg, MD, on August 17, 2019. Throughout his long career, Don was a visionary leader who, earlier than most, saw the potential of technology to improve health care. He was a founder of our field, and he was a steadfast supporter of Methods. Beginning in 1970, when the journal was still a relatively new journal edited

BACKGROUND  In the neonatal intensive care unit (NICU), predefined acuity-based team care models are restricted to core roles and neglect interactions with providers outside of the team, such as interactions that transpire via electronic health record (EHR) systems. These unaccounted interactions may be related to the efficiency of resource allocation, information flow, communication, and thus impact

BACKGROUND  Evaluating potential data losses from mapping proprietary medical data formats to standards is essential for decision making. The article implements a method to evaluate the preliminary content overlap of proprietary medical formats, including national terminologies and Fast Healthcare Interoperability Resources (FHIR)-international medical standard. METHODS  Three types of mappings were

BACKGROUND  Despite recent advances in the field of medical sciences, children's developmental motor disorders (DMDs) are considered as one of the challenges in this area. Establishment of electronic systems for recording and monitoring children's DMDs can play an effective role in identifying patients and reducing the costs and consequences of the disease management. The aim of this study was to identify

BACKGROUND  Students with complex health care services process face constant challenges with regard to health education. The mobile devices are an important tool that can install various applications for using information such as clinical guidelines, drug resources, clinical calculations, and the latest scientific evidence without any time and place limitations. And this happens only when students

BACKGROUND  Modeling human cardiac diseases with induced pluripotent stem cells not only enables to study disease pathophysiology and develop therapies but also, as we have previously showed, it can offer a tool for disease diagnostics. We previously observed that a few genetic cardiac diseases can be separated from each other and healthy controls by applying machine learning to Ca2+ transient signals

BACKGROUND  The interest in information extraction from clinical reports for secondary data use is increasing. But experience with the productive use of information extraction processes over time is scarce. A clinical data warehouse has been in use at our university hospital for several years, which also provides an information extraction of echocardiography reports developed for general use. OBJECTIVES

BACKGROUND The use of receiver operating characteristic curves, or "ROC analysis," has become quite common in biomedical research to support decisions. However, sensitivity, specificity, and misclassification rates are still often estimated using the training sample, overlooking the risk of overrating the test performance. METHODS A simulation study was performed to highlight the inferential implications

BACKGROUND Radiology reports are a permanent record of patient's health information often used in clinical practice and research. Reading radiology reports is common for clinicians and radiologists. However, it is laborious and time-consuming when the amount of reports to be read is large. Assisting clinicians to locate and assimilate the key information of reports is of great significance for improving

BACKGROUND With the increasing personalization of clinical therapies, translational research is evermore dependent on multisite research cooperations to obtain sufficient data and biomaterial. Distributed research networks rely on the availability of high-quality data stored in local databases operated by their member institutions. However, reusing data documented by independent health providers for

OBJECTIVES The quality of hospital discharge care and patient factors (health and sociodemographic) impact the rates of unplanned readmissions. This study aims to measure the effects of controlling for the patient factors when using readmission rates to quantify the weighted edges between health care providers in a collaboration network. This improved understanding may inform strategies to reduce hospital

BACKGROUND Health information technology, especially the electronic health record (EHR) systems, improves health care quality and patient safety. OBJECTIVES This study's objectives are as follows: first, to explore the adoption of EHR systems among physicians in Saudi Arabia (with King Fahd Military Medical Complex as the location of the pilot study), and second, to identify the factors that influence

BACKGROUND The design of computerized systems able to support automated detection of threatening conditions in critically ill patients such as systemic inflammatory response syndrome (SIRS) and sepsis has been fostered recently. The increase of research work in this area is due to both the growing digitalization in health care and the increased appreciation of the importance of early sepsis detection

BACKGROUND The use of electronic medical record (EMR) is anticipated to bring benefits for patients, physicians, and organizations. But limited physicians' acceptance of EMR presents a serious threat to its effective implementation. OBJECTIVES The current study incorporates technology acceptance model (TAM) with two antecedents, gender, and clinical specialty and one context-specific factor, financial

BACKGROUND Hyperglycemia or high blood glucose during surgery is associated with poor postoperative outcome. Knowing in advance which patients may develop hyperglycemia allows optimal assignment of resources and earlier initiation of glucose management plan. OBJECTIVE To develop predictive models to estimate peak glucose levels in surgical patients and to implement the best performing model as a point-of-care

BACKGROUND Health information systems have developed rapidly and considerably during the last decades, taking advantage of many new technologies. Robots used in operating theaters represent an exceptional example of this trend. Yet, the more these systems are designed to act autonomously and intelligently, the more complex and ethical questions arise about serious implications of how future hybrid

OBJECTIVES This article describes a method for developing electronic health record (EHR) tools for use in primary care settings. METHODS The "Translating Research into Agile Development" (TRIAD) method relies on the close collaboration of researchers, end users, and development teams. This five-step method for designing a tailored EHR tool includes (1) assessment, observation, and documentation; (2)

INTRODUCTION The growing number of genetic variants of unknown significance (VUS) and availability of several in silico prediction tools make the evaluation of potentially deleterious gene variants challenging. MATERIALS AND METHODS We evaluated several programs and software to determine the one that can predict the impact of genetic variants found in lysosomal storage disorders (LSDs) caused by defects

BACKGROUND In shared decision-making, a key step is quantifying the patient's preferences in relation to all the possible outcomes of the compared clinical options. According to utility theory, this can be done by eliciting utility coefficients (UCs) from the patient. The obtained UCs are then used in decision models (e.g., decision trees). The elicitation process involves the choice of one or more

OBJECTIVES To investigate the performance of texture analysis in characterizing P53 mutations of hepatocellular carcinomas (HCCs) based on computed tomography (CT). METHODS A total of 63 HCC patients underwent CT scans and were tested for P53 mutations. Patients were divided into two groups of P53(-) and P53(+) according to the P53 scores. First- and second-order texture features were computed from

OBJECTIVE Poor lifestyle represents a health risk factor and is the leading cause of morbidity and chronic conditions. The impact of poor lifestyle can be significantly altered by individual's behavioral modification. Although there are abundant lifestyle promotion applications and tools, they are still limited in providing tailored social support that goes beyond their predefined functionalities.

BACKGROUND As healthcare increasingly digitizes, streaming waveform data is being made available from an variety of sources, but there still remains a paucity of performant clinical decision support systems. For example, in the intensive care unit (ICU) existing automated alarm systems typically rely on simple thresholding that result in frequent false positives. Recurrent false positive alerts create

OBJECTIVES Automatic de-identification to remove protected health information (PHI) from clinical text can use a "binary" model that replaces redacted text with a generic tag (e.g., ""), or can use a "multiclass" model that retains more class information (e.g., ""). Binary models are easier to develop, but result in text that is potentially less informative. We investigated whether building a multiclass

OBJECTIVES To identify major research subjects and trends in medical informatics research based on the current set of core medical informatics journals. METHODS Analyzing journals in the Web of Science (WoS) medical informatics category together with related categories from the years 2013 to 2017 by using a smart local moving algorithm as a clustering method for identifying the core set of journals

OBJECTIVE The objective of this article was to compare the performances of health care-associated infection (HAI) detection between deep learning and conventional machine learning (ML) methods in French medical reports. METHODS The corpus consisted in different types of medical reports (discharge summaries, surgery reports, consultation reports, etc.). A total of 1,531 medical text documents were extracted

Computational Intelligence Re-meets Medical Image Processing Analysis of Machine Learning Algorithms for Diagnosis of Diffuse Lung Diseases BACKGROUND:  In the last decades, new optimization methods based on the nature's intelligence were developed. These metaheuristics can find a nearly optimal solution faster than other traditional algorithms even for high-dimensional optimization problems. All these

OBJECTIVE Self-anamnesis is a procedure in which a patient answers questions about the personal medical history without interacting directly with a doctor or medical assistant. If collected digitally, the anamnesis data can be shared among the health care team. In this article, we introduce a concept for digital anamnesis collection and assess the applicability of a conversational user interface (CUI)

Computational Intelligence Re-meets Medical Image Processing A Comparison of Some Nature-Inspired Optimization Metaheuristics Applied in Biomedical Image Registration BACKGROUND:  Diffuse lung diseases (DLDs) are a diverse group of pulmonary disorders, characterized by inflammation of lung tissue, which may lead to permanent loss of the ability to breathe and death. Distinguishing among these diseases

BACKGROUND Electronic health record (EHR) systems contain large volumes of novel heterogeneous data that can be linked to trauma registry data to enable innovative research not possible with either data source alone. OBJECTIVE This article describes an approach for linking electronically extracted EHR data to trauma registry data at the institutional level and assesses the value of probabilistic linkage

BACKGROUND Smoking is an established risk factor for oral diseases and, therefore, dental clinicians routinely assess and record their patients' detailed smoking status. Researchers have successfully extracted smoking history from electronic health records (EHRs) using text mining methods. However, they could not retrieve patients' smoking intensity due to its limited availability in the EHR. The presence

BACKGROUND Trauma is a global burden. Emergency medical services (EMS) provide care for individuals who have serious injuries or suffered a major trauma. OBJECTIVE This paper provides a comprehensive overview of telemedicine applications in prehospital trauma care. METHODS We conducted a systematic review according to PRISMA guidelines. We identified articles by electronic database search (PubMed,

INTRODUCTION This accompanying editorial provides a brief introduction to this focus theme, focused on "Machine Learning and Data Analytics in Pervasive Health". OBJECTIVE The innovative use of machine learning technologies combining small and big data analytics will support a better provisioning of healthcare to citizens. This focus theme aims to present contributions at the crossroads of pervasive

OBJECTIVES Pharmacogenomics (PGx) is often considered a low-hanging fruit for genomics-electronic health record (EHR) integrations, and many have expressed the notion that drug-gene interaction checking might one day become as much a commodity in EHRs as drug-drug and drug-allergy checking. In addition, the U.S. Office of the National Coordinator has recognized the trend toward storing complete sequencing

BACKGROUND Patient-reported outcomes (PROs) are information provided directly by patients that helps in improving patient diagnosis and treatment. Validated translations of PROs can be used to treat international patients. Electronic systems and especially mobile devices provide a great opportunity for their collection; however, these systems are normally study-oriented and therefore single language

BACKGROUND Radiotherapy has serious side effects and thus requires prudent and cautious evaluation. However, obtaining protein expression profiles is expensive and timeconsuming, making it necessary to develop a theoretical and rational procedure for predicting the radiotherapy outcome for bladder cancer when working with limited data. OBJECTIVE A procedure for estimating the performance of radiotherapy

OBJECTIVE Alzheimer's disease (AD) is one of the most prevalent diseases among the adult population. The early detection of Mild Cognitive Impairment (MCI), which may trigger AD, is essential to slow down the cognitive decline process. METHODS This paper presents a suit of serious games that aims at detecting AD and MCI overcoming the limitations of traditional tests, as they are time-consuming, affected

OBJECTIVES Our goal was to develop predictive models for sepsis and in-hospital mortality using electronic health records (EHRs). We showcased the efficiency of these algorithms in patients diagnosed with pneumonia, a group that is highly susceptible to sepsis. METHODS We retrospectively analyzed the Health Facts® (HF) dataset to develop models to predict mortality and sepsis using the data from the