Digital slide images produced from routine diagnostic histopathological preparations suffer from variation arising at every step of the processing pipeline. Typically, pathologists compensate for such variation using expert knowledge and experience, which is difficult to replicate in automated solutions. The extent to which inconsistencies affect image analysis is explored in this work, examining in

Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic that has spread rapidly since December 2019. Real-time reverse transcription polymerase chain reaction (rRT-PCR) and chest computed tomography (CT) imaging both play an important role in COVID-19 diagnosis. Chest CT imaging offers the benefits of quick reporting, a low cost, and high sensitivity for the detection of pulmonary infection

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Early and accurate diagnosis of Coronavirus disease (COVID-19) is essential for patient isolation and contact tracing so that the spread of infection can be limited. Computed tomography (CT) can provide important information in COVID-19, especially for patients with moderate to severe disease as well as those with worsening cardiopulmonary status. As an automatic tool, deep learning methods can be

To counter the outbreak of COVID-19, the accurate diagnosis of suspected cases plays a crucial role in timely quarantine, medical treatment, and preventing the spread of the pandemic. Considering the limited training cases and resources ( e.g , time and budget), we propose a Multi-task Multi-slice Deep Learning System (M $^3$ Lung-Sys) for multi-class lung pneumonia screening from CT imaging, which

The novel coronavirus disease 2019 (COVID-19) pandemic has led to a worldwide crisis in public health. It is crucial we understand the epidemiological trends and impact of non-pharmacological interventions (NPIs), such as lockdowns for effective management of the disease and control of its spread. We develop and validate a novel intelligent computational model to predict epidemiological trends of COVID-19

Since its outbreak in December 2019, the persistent coronavirus disease (COVID-19) became a global health emergency. It is imperative to develop a prognostic tool to identify high-risk patients and assist in the formulation of treatment plans. We retrospectively collected 366 severe or critical COVID-19 patients from four centers, including 70 patients who died within 14 days (labeled as high-risk

Objective: The coronavirus disease 2019 (COVID-19) is rapidly spreading inside China and internationally. We aimed to construct a model integrating information from radiomics and deep learning (DL) features to discriminate critical cases from severe cases of COVID-19 using computed tomography (CT) images. Methods: We retrospectively enrolled 217 patients from three centers in China, including 82 patients

Currently, Coronavirus disease (COVID-19), one of the most infectious diseases in the 21st century, is diagnosed using RT-PCR testing, CT scans and/or Chest X-Ray (CXR) images. CT (Computed Tomography) scanners and RT-PCR testing are not available in most medical centers and hence in many cases CXR images become the most time/cost effective tool for assisting clinicians in making decisions. Deep learning

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Accurate segmentation of lung cancer in pathology slides is a critical step in improving patient care. We proposed the ACDC@LungHP (Automatic Cancer Detection and Classification in Whole-slide Lung Histopathology) challenge for evaluating different computer-aided diagnosis (CADs) methods on the automatic diagnosis of lung cancer. The ACDC@LungHP 2019 focused on segmentation (pixel-wise detection) of

The kidney biopsy based diagnosis of Lupus Nephritis (LN) is characterized by low inter-observer agreement, with misdiagnosis being associated with increased patient morbidity and mortality. Although various Computer Aided Diagnosis (CAD) systems have been developed for other nephrohistopathological applications, little has been done to accurately classify kidneys based on their kidney level Lupus

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The fifteen articles in this special section focus on data science used in smart healthcare applications. A shift toward a data-driven socio-economic health model is occurring. This is the result of the increased volume, velocity and variety of data collected from the public and private sector in healthcare, and biology in general. In the past five-years, there has been an impressive development of

Process mining is a suitable method for knowledge extraction from patient pathways. Structured in event logs, medical events are complex, often described using various medical codes. An efficient labeling of these events before applying process mining analysis is challenging. This paper presents an innovative methodology to handle the complexity of events in medical event logs. Based on autoencoding

The articles in this special section focus on flexible sensing and medical imaging for cerebro-cardiovascular health care services. Healthcare and disease management are receiving increasing attention. Cerebro-cardiovascular diseases (CCVDs) are the leading cause of death globally. Cerebrocardiovascular diseases include a variety of medical conditions that affect the blood vessels of the brain, the

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The high capacity of neural networks allows fitting models to data with high precision, but makes generalization to unseen data a challenge. If a domain shift exists, i.e. differences in image statistics between training and test data, care needs to be taken to ensure reliable deployment in real-world scenarios. In digital pathology, domain shift can be manifested in differences between whole-slide

Today Information in the world wide web is overwhelmed by unprecedented quantity of data on versatile topics with varied quality. However, the quality of information disseminated in the field of medicine has been questioned as the negative health consequences of health misinformation can be life-threatening. There is currently no generic automated tool for evaluating the quality of online health information

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The papers in this special section focuses on artificial intelligent-driven informatics, sensing, imaging and big data analytics in dealing with the COVID-19 pandemic.

Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide since first reported. Timely diagnosis of COVID-19 is crucial both for disease control and patient care. Non-contrast thoracic computed tomography (CT) has been identified as an effective tool for the diagnosis, yet the disease outbreak has placed tremendous pressure on radiologists for reading the exams and may potentially lead to fatigue-related

Chest computed tomography (CT) becomes an effective tool to assist the diagnosis of coronavirus disease-19 (COVID-19). Due to the outbreak of COVID-19 worldwide, using the computed-aided diagnosis technique for COVID-19 classification based on CT images could largely alleviate the burden of clinicians. In this paper, we propose an A daptive F eature S election guided D eep F orest (AFS-DF) for COVID-19

The pandemic of coronavirus disease 2019 (COVID-19) has lead to a global public health crisis spreading hundreds of countries. With the continuous growth of new infections, developing automated tools for COVID-19 identification with CT image is highly desired to assist the clinical diagnosis and reduce the tedious workload of image interpretation. To enlarge the datasets for developing machine learning

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Mitotic count is an important indicator for assessing the invasiveness of breast cancers. Currently, the number of mitoses is manually counted by pathologists, which is both tedious and time-consuming. To address this situation, we propose a fast and accurate method to automatically detect mitosis from the histopathological images. The proposed method can automatically identify mitotic candidates from

Dry eye syndrome is one of the most frequently reported eye diseases in ophthalmological practice. The diagnosis of this disease is a challenging task due to its multifactorial etiology. One of the most applied tests is the manual classification of tear film images captured with the Doane interferometer. The interference phenomena in these images can be characterized as texture patterns, which can

Remote photoplethysmography (rPPG) is an unobtrusive solution to heart rate monitoring in drivers. However, disturbances that occur during driving such as driver behavior, motion artifacts, and illuminance variation complicate the monitoring of heart rate. Faced with disturbance, one commonly used assumption is heart rate periodicity (or spectrum sparsity). Several methods improve stability at the

Objective: Two-dimensional fluoroscopy is the standard guidance imaging method for closed endovascular intervention. However, two-dimensional fluoroscopy lacks depth perception for the intervention catheter and causes radiation exposure for both surgeons and patients. In this paper, we extend our previous study and develop the improved three-dimensional (3D) catheter shape estimation using ultrasound

To slow down the spread of COVID-19, governments worldwide are trying to identify infected people, and contain the virus by enforcing isolation, and quarantine. However, it is difficult to trace people who came into contact with an infected person, which causes widespread community transmission, and mass infection. To address this problem, we develop an e-government Privacy-Preserving Mobile, and Fog

The iterative design of radiotherapy treatment plans is time-consuming and labor-intensive. In order to provide a guidance to treatment planning, Asymmetric network (A-Net) is proposed to predict the optimal 3D dose distribution for lung cancer patients. A-Net was trained and tested in 392 lung cancer cases with the prescription doses of 50Gy and 60Gy. In A-Net, the encoder and decoder are asymmetric

Radiomics has shown remarkable potential for predicting the survival outcome for various types of cancers such as pancreatic ductal adenocarcinoma (PDAC). However, to date, there has been limited research using convolutional neural networks (CNN) with radiomic methods for this task, due to their requirement for large training sets. To overcome this issue, we propose a new type of radiomic descriptor

Recognizing the movements during sleep is crucial for the monitoring of patients with sleep disorders. However, the utilization of Ultra-Wideband (UWB) radar for the classification of human sleep postures has not been explored widely. This study investigates the performance of the off-the-shelf single antenna UWB in a novel application of sleep postural transition (SPT) recognition. The proposed Multi-View

Recently, the advances in passive brain-computer interfaces (BCIs) based on electroencephalogram (EEG) have shed light on real-world neuromonitoring technologies. However, human variability in the EEG activities hinders the development of practical applications of EEG-based BCI. To tackle this problem, many transfer-learning techniques perform supervised calibration. This kind of calibration approach

Vertigo is a type of dizziness characterised by the subjective feeling of movement despite being stationary. One in four individuals in the community experience symptoms of dizziness at any given time, and it can be challenging for clinicians to diagnose the underlying cause. When dizziness is the result of a malfunction in the inner-ear, the eyes flicker and this is called nystagmus. In this article

Pneumothorax is potentially a life-threatening disease that requires urgent diagnosis and treatment. The chest X-ray is the diagnostic modality of choice when the pneumothorax is suspected. Computer-aided diagnosis of pneumothorax has got a dramatic boost in the last years due to deep learning advances and the first public pneumothorax diagnosis competition with 15257 chest X-rays manually annotated

Falls are a significant problem for persons with multiple sclerosis (PwMS). Yet fall prevention interventions are not often prescribed until after a fall has been reported to a healthcare provider. While still nascent, objective fall risk assessments could help in prescribing preventative interventions. To this end, retrospective fall status classification commonly serves as an intermediate step in

We propose a method for calculating standard spatiotemporal gait parameters from individual human joints with a side-view depth sensor. Clinical walking trials were measured concurrently by a side-view Kinect and a pressure-sensitive walkway, the Zeno Walkway. Multiple joint proposals were generated from depth images by a stochastic predictor based on the Kinect algorithm. The proposals are represented

Stroke survivors are often characterized by hemiparesis, i.e., paralysis in one half of the body, severely affecting upper limb movements. Monitoring the progression of hemiparesis requires manual observation of limb movements at regular intervals, and hence is a labour intensive process. In this work, we use wrist-worn accelerometers for automated assessment of hemiparesis in acute stroke. We propose

Accurate segmentation and segmentation of lesions in PET images provide computer-aided procedures and doctors with parameters for tumour diagnosis, staging and prognosis. Currently, PET segmentation and lesion partitioning are manually measured by radiologists, which is time consuming and laborious, and tedious manual procedures might lead to inaccurate measurement results. Therefore, we designed a

Digital histopathology image segmentation can facilitate computer-assisted cancer diagnostics. Given the difficulty of obtaining manual annotations, weak supervision is more suitable for the task than full supervision is. However, most weakly supervised models are not ideal for handling severe intra-class heterogeneity and inter-class homogeneity in histopathology images. Therefore, we propose a novel

In this work, we have focused on the segmentation of Focal Cortical Dysplasia (FCD) regions from MRI images. FCD is a congenital malformation of brain development that is considered as the most common causative of intractable epilepsy in adults and children. To our knowledge, the latest work concerning the automatic segmentation of FCD was proposed using a fully convolutional neural network (FCN) model

Pancreas identification and segmentation is an essential task in the diagnosis and prognosis of pancreas disease. Although deep neural networks have been widely applied in abdominal organ segmentation, it is still challenging for small organs (e.g. pancreas) that present low contrast, highly flexible anatomical structure and relatively small region. In recent years, coarse-to-fine methods have improved

AD is the highly severe part of the dementia spectrum and impairs cognitive abilities of individuals, bringing economic, societal and psychological burdens beyond the diseased. A promising approach in AD research is the analysis of structural and functional brain connectomes, i.e. sNETs and fNETs, respectively. We propose to use tensor representation (B-tensor) of uni-modal and multi-modal brain connectomes

Optical Coherence Tomography Angiography (OCTA) is a novel, non-invasive imaging modality of retinal capillaries at micron resolution. Recent studies have correlated macular OCTA vascular measures with retinal disease severity and supported their use as a diagnostic tool. However, these measurements mostly rely on a few summary statistics in retinal layers or regions of interest in the two-dimensional

The choroid provides oxygen and nourishment to the outer retina thus is related to the pathology of various ocular diseases. Optical coherence tomography (OCT) is advantageous in visualizing and quantifying the choroid in vivo . However, its application in the study of the choroid is still limited for two reasons. (1) The lower boundary of the choroid (choroid-sclera interface) in OCT is fuzzy, which

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We propose an intracranial electroencephalography (iEEG) based algorithm for detecting epileptic seizures with short latency, and with identifying the most relevant electrodes. Our algorithm first extracts three features, namely mean amplitude, line length, and local binary patterns that are fed to an ensemble of classifiers using hyperdimensional (HD) computing. These features are embedded into an

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The eleven papers presented in this special issue provide a snapshot of the latest advances in the field of enabling technologies in health engineering and health informatics for the new revolution of Healthcare 4.0, hoping to further enable, drive and accelerate the research, development, and application of key technologies into healthcare systems.