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Incorporating Process Utility into Cost-Effectiveness Analysis via a Bolt-On Domain to the SF-6D: An Exploratory Study Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-03-30 Victoria K. Brennan, Georgina Jones, Stephen Radley, Simon Dixon
Background Within the UK, standard methods of economic evaluation centre on the maximisation of the quality-adjusted life-year (QALY). However, preference-based measures used to estimate QALYs may not be suited to all economic evaluations, as they routinely measure only health outcomes. Aim This study used an economic evaluation alongside a clinical trial (EEACT) comparing patients’ preferences for
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Correction to: Translating Research to Policy: Setting Provider Payment Rates for Strategic Purchasing under India’s National Publicly Financed Health Insurance Scheme Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-03-26 Shankar Prinja, Maninder Pal Singh, Kavitha Rajsekar, Oshima Sachin, Praveen Gedam, Anu Nagar, Balram Bhargava
A correction to this paper has been published: https://doi.org/10.1007/s40258-021-00645-5
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Preferences for Medical Consultations from Online Providers: Evidence from a Discrete Choice Experiment in the United Kingdom Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-03-08 James Buchanan, Laurence S. J. Roope, Liz Morrell, Koen B. Pouwels, Julie V. Robotham, Lucy Abel, Derrick W. Crook, Tim Peto, Christopher C. Butler, A. Sarah Walker, Sarah Wordsworth
Background In the UK, consultations for prescription medicines are available via private providers such as online pharmacies. However, these providers may have lower thresholds for prescribing certain drugs. This is a particular concern for antibiotics, given the increasing burden of antimicrobial resistance. Public preferences for consultations with online providers are unknown, hence the impact of
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Cost-Effectiveness and Value of Information of Cabozantinib Treatment for Patients with Advanced Renal Cell Carcinoma After Failure of Prior Therapy in South Korea Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-03-02 Siin Kim, Sola Han, Hyungtae Kim, Hae Sun Suh
Objective To estimate the cost-effectiveness and value of information of cabozantinib compared to nivolumab in advanced renal cell carcinoma (RCC) patients, who previously failed treatment from a societal perspective in South Korea. Methods A partitioned survival model was used to evaluate the incremental cost-utility ratio (ICUR) of cabozantinib versus nivolumab. Overall survival (OS) and progression-free
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Cost-effectiveness of Interventions for Chronic Fatigue Syndrome or Myalgic Encephalomyelitis: A Systematic Review of Economic Evaluations Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-03-01 M. Cochrane, E. Mitchell, W. Hollingworth, E. Crawley, D. Trépel
Introduction Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has profound quality of life and economic consequences for individuals, their family, formal services and wider society. Little is known about which therapeutic interventions are more cost-effective. Objective A systematic review was carried out to identify and critically appraise the evidence on the cost-effectiveness of CFS/ME
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Willingness to Pay for a COVID-19 Vaccine Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-02-23 Arcadio A. Cerda, Leidy Y. García
Background The coronavirus disease (COVID-19) pandemic has considerably affected the lives of people worldwide, impacting their health and economic welfare, and changing the behavior of our society significantly. This situation may lead to a strong incentive for people to buy a vaccine. Therefore, a relevant study to assess individuals’ choices and the value of change in welfare from a COVID-19 vaccine
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Costs of Illness of Spinal Muscular Atrophy: A Systematic Review Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-02-12 Erik Landfeldt, Astrid Pechmann, Hugh J. McMillan, Hanns Lochmüller, Thomas Sejersen
Objectives The objective of our study was to conduct a systematic literature review of estimates of costs of illness of spinal muscular atrophy (SMA). Methods We searched MEDLINE (through PubMed), CINAHL, Embase, Web of Science, National Health Service Economic Evaluation Database, and the National Health Service Health Technology Assessment Database for studies published from inception up until 31
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Economic Analyses of Pathogen-Reduction Technologies in Blood Transfusion: A Systematic Literature Review Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-02-08 Patrick R. LaFontaine, Jing Yuan, Katherine M. Prioli, Priti Shah, Jay H. Herman, Laura T. Pizzi
Background Technologies used in the processing of whole blood and blood component products, including pathogen reduction, are continuously being adopted into blood transfusion workflows to improve process efficiencies. However, the economic implications of these technologies are not well understood. With the advent of these new technologies and regulatory guidance on bacterial risk-control strategies
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The Danish EQ-5D-5L Value Set: A Hybrid Model Using cTTO and DCE Data Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-02-02 Cathrine Elgaard Jensen, Sabrina Storgaard Sørensen, Claire Gudex, Morten Berg Jensen, Kjeld Møller Pedersen, Lars Holger Ehlers
Objectives Quality-adjusted life-years (QALYs) are expected to be used for priority setting of hospital-dispensed medicines in Denmark from 2021. The aim of this study was to develop the first Danish value set for the EQ-5D-5L based on interviews with a representative sample of the Danish adult population. Methods A nationally representative sample based on age (> 18 years), gender, education, and
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The Budget Impact of Monoclonal Antibodies Used to Treat Metastatic Colorectal Cancer in Minas Gerais, Brazil Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-01-28 Wânia Cristina da Silva, Brian Godman, Francisco de Assis Acúrcio, Mariângela Leal Cherchiglia, Antony Martin, Konrad Maruszczyk, Jans Bastos Izidoro, Marcos André Portella, Agner Pereira Lana, Orozimbo Henriques Campos Neto, Eli Iola Gurgel Andrade
Introduction Biological medicines have increased the cost of cancer treatments, which also raises concerns about sustainability. In Brazil, three monoclonal antibodies (mAbs)—bevacizumab, cetuximab, and panitumumab—are indicated for the treatment of metastatic colorectal cancer (mCRC) but not currently funded by the Unified Health System (SUS). However, successful litigation has led to funding in some
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Does Biosimilar Bevacizumab Offer Affordable Treatment Options for Cancer Patients in the USA? A Budget Impact Analysis from US Commercial and Medicare Payer Perspectives Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-01-28 Jingyan Yang, Rongzhe Liu, Varun Ektare, Jennifer Stephens, Ahmed Shelbaya
Background Bevacizumab remains the most widely used and most thoroughly characterized angiogenesis inhibitor for a range of advanced cancers. Bevacizumab-bvzr (Zirabev®), a biosimilar of bevacizumab, was recently approved by the US Food and Drug Administration (FDA), which provides a less costly option. This study aimed to evaluate the financial impact of introducing bevacizumab-bvzr from US commercial
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Opioid Prescribing in Canada following the Legalization of Cannabis: A Clinical and Economic Time-Series Analysis Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-01-25 George Dranitsaris, Carlo DeAngelis, Blake Pearson, Laura McDermott, Bernd Pohlmann-Eden
Purpose On 17 October 2018 recreational cannabis became legal in Canada, thereby increasing access and reducing the stigma associated with its use for pain management. This study assessed total opioid prescribing volumes and expenditures prior to and following cannabis legalization. Methods National monthly claims data for public and private payers were obtained from January 2016 to June 2019. The
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Cost of Medicare for All: Review of the Estimates Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-01-25 John A. Nyman
This paper critically evaluates the estimates of the cost of Medicare for All (M4A) in the USA. Six studies that estimate the 1-year total cost of M4A in the USA are reviewed. These studies find that M4A would increase national health spending by as much as 16.9% or decrease it by 20.0%, representing a range of estimates that generates uncertainty and confusion regarding what to expect if M4A were
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Translating Research to Policy: Setting Provider Payment Rates for Strategic Purchasing under India's National Publicly Financed Health Insurance Scheme Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-01-19 Shankar Prinja, Maninder Pal Singh, Kavitha Rajsekar, Oshima Sachin, Praveen Gedam, Anu Nagar, Balram Bhargava
Background In 2018, the Government of India launched Ayushman Bharat Pradhan Mantri-Jan Aarogya Yojana (AB PM-JAY), a large tax-funded health insurance scheme. In this paper, we present findings of the Costing of Health Services in India (CHSI) study, describe the process of use of cost evidence for price-setting under AB PM-JAY, and estimate its fiscal impact. Methods Reference costs were generated
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How Many Intensive Care Beds are Justifiable for Hospital Pandemic Preparedness? A Cost-effectiveness Analysis for COVID-19 in Germany Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-01-12 Afschin Gandjour
Introduction Germany is experiencing the second COVID-19 pandemic wave. The intensive care unit (ICU) bed capacity is an important consideration in the response to the pandemic. The purpose of this study was to determine the costs and benefits of maintaining or expanding a staffed ICU bed reserve capacity in Germany. Methods This study compared the provision of additional capacity to no intervention
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Cost-Effectiveness Analysis of Parenteral Methotrexate for the Treatment of Crohn’s Disease Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-01-11 Tomas Mlcoch, Barbora Decker, Tomas Dolezal
Background Despite worldwide use of parenteral methotrexate (pMTX), health economic evidence for its use in Crohn’s disease (CD) is limited. The low price of this generic drug has removed any commercial incentive to further invest in research. However, there is an unmet need for treatment of mild-to-moderate CD, since biological/targeted therapies are usually reserved for patients with more severe
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Copula Models for Addressing Sample Selection in the Evaluation of Public Health Programmes: An Application to the Leeds Let’s Get Active Study Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-01-11 Paolo Candio, Andrew J. Hill, Stavros Poupakis, Anni-Maria Pulkki-Brännström, Chris Bojke, Manuel Gomes
Sample selectivity is a recurrent problem in public health programmes and poses serious challenges to their evaluation. Traditional approaches to handle sample selection tend to rely on restrictive assumptions. The aim of this paper is to illustrate a copula-based selection model to handle sample selection in the evaluation of public health programmes. Motivated by a public health programme to promote
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Which Criteria are Considered and How are They Evaluated in Health Technology Assessments? A Review of Methodological Guidelines Used in Western and Asian Countries Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2021-01-11 Yitong Wang, Tingting Qiu, Junwen Zhou, Clément Francois, Mondher Toumi
Objectives This study aimed to provide an exhaustive description of criteria and methodological recommendations for evaluating them in health technology assessment (HTA) in Western and Asian countries. Methods We conducted a system literature review of HTA-related guidelines by searching the websites of HTA agencies and related data sources. The guidelines, reports, or recommendations introducing the
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Elections have Consequences: Partisan Politics may be Literally Killing Us Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-12-18 Alexander Maas, Liang Lu
Background Presidential campaigns and election outcomes have significant health implications for voters and communities. The theoretical underpinning of this relationship is multifaceted, but a new and growing field of empirical literature strongly suggests communities that voted for the losing presidential candidate may experience decreased physical and mental health under the leadership of the winning
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The Indirect Cost Burden of Cancer Care in Canada: A Systematic Literature Review Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-12-24 Nicolas Iragorri, Claire de Oliveira, Natalie Fitzgerald, Beverley Essue
Background and objectives Cancer poses a substantial health and economic burden on patients and caregivers in Canada. Previous reviews have estimated the indirect cost burden as work-related productivity losses associated with cancer. However, these estimates require updating and complementing with more comprehensive data that include relevant dimensions beyond labor market costs, such as patient time
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Management of Chest Indrawing Pneumonia in Children Under Five Years at the Outpatient Health Facilities in Nigeria: An Economic Evaluation Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-12-23 Charles E. Okafor
Background The recommendation of the World Health Organization (WHO) for the management of children aged < 5 years with chest indrawing pneumonia with oral amoxicillin dispersible tablets (DT) at the outpatient health facilities is imperative, especially in a high pneumonia mortality and low-resource setting like Nigeria. However, this recommendation has not been widely adopted in Nigeria due to poor
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What is the Impact of the Analysis Method Used for Health State Utility Values on QALYs in Oncology? A Simulation Study Comparing Progression-Based and Time-to-Death Approaches Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-12-14 Anthony J. Hatswell, Ash Bullement, Michael Schlichting, Murtuza Bharmal
Background Health state utility values (‘utilities’) are an integral part of health technology assessment. Though traditionally categorised by disease status in oncology (i.e. progression), several recent assessments have adopted values calculated according to the time that measures were recorded before death. We conducted a simulation study to understand the limitations of each approach, with a focus
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Correction to: Articles in Themed Issue: Health Financing in Sub-Saharan Africa Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-11-30
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Prescription Drug Monitoring Programs and Opioid Prescriptions for Disability Conditions Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-11-30 Orgul Ozturk, Yuan Hong, Suzanne McDermott, Margaret Turk
Background There are variants of prescription drug monitoring programs (PDMPs) and different groups of patients who are prescribed opioids. Patients with disabilities and those with chronic conditions might have different experiences in physician prescribing practices for opioids, when compared to a comparison group without these conditions. Objective To determine differences in opioid prescriptions
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Cost Effectiveness of Case Detection Strategies for the Early Detection of COPD Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-11-02 Kate M. Johnson, Mohsen Sadatsafavi, Amin Adibi, Larry Lynd, Mark Harrison, Hamid Tavakoli, Don D. Sin, Stirling Bryan
Objectives The value of early detection and treatment of chronic obstructive pulmonary disease (COPD) is currently unknown. We assessed the cost effectiveness of primary care-based case detection strategies for COPD. Methods A previously validated discrete event simulation model of the general population of COPD patients in Canada was used to assess the cost effectiveness of 16 case detection strategies
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Correction to: Cost Effectiveness of Introducing Etonorgestrel Contraceptive Implant into India’s Current Family Welfare Programme Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-10-27 Beena Joshi, Kusum V. Moray, Oshima Sachin, Himanshu Chaurasia, Shahina Begum
The original article can be found online.
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The Cost-Effectiveness of Pulmonary Rehabilitation for COPD in Different Settings: A Systematic Review Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-10-20 Shengnan Liu, Qiheng Zhao, Wenshuo Li, Xuetong Zhao, Kun Li
Background Chronic obstructive pulmonary disease (COPD) has high morbidity and mortality rates. COPD impairs body functioning, reduces quality of life, and creates a great economic burden for society. Pulmonary rehabilitation (PR) has become an important nonpharmacological treatment for COPD. This paper systematically reviews economic evaluations of PR in COPD patients in different settings. Objectives
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Identifying Community Pharmacist Preferences For Prescribing Services in Primary Care in New Zealand: A Discrete Choice Experiment Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-10-19 Rakhee Raghunandan, Kirsten Howard, Carlo A. Marra, June Tordoff, Alesha Smith
Objective Given increasing patient populations, general practitioner (GP) workforce constraints and increasing demand for health services in New Zealand (NZ), the development and provision of pharmacist prescribing services may need to increase to improve people’s access to medicines. A discrete choice experiment (DCE) was utilised to determine community pharmacist preferences for prescribing services
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The Cost-Effectiveness of Kidney Replacement Therapy Modalities: A Systematic Review of Full Economic Evaluations Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-10-13 Fei Yang, Meixia Liao, Pusheng Wang, Zheng Yang, Yongguang Liu
Background Kidney replacement therapy (KRT) is a lifesaving but costly treatment for patients with end-stage kidney disease (ESKD). The objective of this study was to review full economic evaluations comparing KRT modalities specified as hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT) for patients with ESKD. Methods We conducted a systematic review of the literature from
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Impact of Guidelines on the Diffusion of Medical Technology: A Case Study of Cardiac Resynchronization Therapy in the UK Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-09-24 Rucha Vadia, Tom Stargardt
Introduction Research on clinical practice guidelines as a determinant of the diffusion of medical technology remains sparse. We aim to evaluate the impact of guidelines on the awareness of medical technology, as a proxy of its use, with the example of cardiac resynchronization therapy (CRT) in the United Kingdom (UK). Methods We measured clinician awareness based on Google searches performed for CRT
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Budget Impact of Microbial Cell-Free DNA Testing Using the Karius ® Test as an Alternative to Invasive Procedures in Immunocompromised Patients with Suspected Invasive Fungal Infections Appl. Health Econ. Health Policy (IF 2.442) Pub Date : 2020-09-17 Ann T. MacIntyre, Alex Hirst, Radha Duttagupta, Desiree Hollemon, David K. Hong, Timothy A. Blauwkamp
Background Invasive fungal infection is a major source of morbidity and mortality. The usage of microbial cell-free DNA for the detection and identification of invasive fungal infection has been considered as a potential alternative to invasive procedures allowing for rapid results. Objective This analysis aimed to assess the budget implications of using the Karius® Test in patients suspected of invasive