A time-serial multi-block modeling (TSMBM) algorithm is proposed for dynamic process monitoring, which considers a unified framework of multi-block modeling and auto-correlation extraction. The proposed TSMBM-based method first constructs time-serial multi-blocks according to the sampling time nodes, the correlation between different blocks then serves as a good representation for the auto-correlated

This paper deals with structured multi-agent optimization problems that involve coupled local and global decision variables. We propose an iterative distributed algorithm that explicitly accounts for this structure, and requires the agents to communicate only their tentative solutions for the global variables throughout iterations. Our approach extends to structured multi-agent optimization a proximal-based

Complex industrial processes such as the drying of combustible biomass can be modeled with partial differential equations. Due to their complexity, it is not straightforward to use these models for the analysis of system properties or for solving optimal control problems. We show reduced order models can be derived and used for these purposes for industrial drying processes.

Current artificial pancreas systems (AP) operate via subcutaneous (SC) glucose sensing and SC insulin delivery. Due to slow diffusion and transport dynamics across the interstitial space, even the most sophisticated control algorithms in on-body AP systems cannot react fast enough to maintain tight glycemic control under the effect of exogenous glucose disturbances caused by ingesting meals or performing

Supervision and control systems rely on signals from sensors to receive information to monitor the operation of a system and adjust manipulated variables to achieve the control objective. However, sensor performance is often limited by their working conditions and sensors may also be subjected to interference by other devices. Many different types of sensor errors such as outliers, missing values,

A multi-parametric model predictive control (mpMPC) algorithm for subcutaneous insulin delivery for individuals with type 1 diabetes mellitus (T1DM) that is computationally efficient, robust to variations in insulin sensitivity, and involves minimal burden for the user is proposed. System identification was achieved through impulse response tests feasible for ambulatory conditions on the UVa/Padova

Evolution has long been understood as the driving force for many problems of medical interest. The evolution of drug resistance in HIV and bacterial infections is recognized as one of the most significant emerging problems in medicine. In cancer therapy, the evolution of resistance to chemotherapeutic agents is often the differentiating factor between effective therapy and disease progression or death

As the "artificial pancreas" becomes closer to reality, automated insulin delivery based on real-time glucose measurements becomes feasible for people with diabetes. This paper is concerned with the development of novel feedforward-feedback control strategies for real-time glucose control and type 1 diabetes. Improved post-meal responses can be achieved by a pre-prandial snack or bolus, or by reducing

Maintaining good glycemic control is a daily challenge for people with type 1 diabetes. Insulin requirements are changing constantly due to many factors, such as levels of stress and physical activity. The basal insulin requirement also has a circadian rhythm, adding another level of complexity. Automating the adjustment of insulin dosing would result in improved glycemic control, as well as an improved