Recently, the event prediction on time series (EPTs) was discussed as one of the important and interesting research trends that its usage is growing for taking proper decisions in the various sciences. In the real-world, time series event-based analysis can pose as one of the challenging prediction problems in healthcare, which have a direct impact and a key role in supporting health management. In

Due to low tissue contrast, irregular shape, and large location variance, segmenting the objects from different medical imaging modalities (e.g., CT, MR) is considered as an important yet challenging task. In this paper, we present a novel method for interactive medical image segmentation with the following merits. (1) Our design is fundamentally different from previous pure patch-based and image-based

Background Motor vehicle accidents (MVA) represent a significant burden on health systems globally. Tens of thousands of people are injured in Australia every year and may experience significant disability. Associated economic costs are substantial. There is little literature on the health service utilization patterns of MVA patients. To fill this gap, this study has been designed to investigate temporal

Dental panoramic X-ray imaging is a popular diagnostic method owing to its very small dose of radiation. For an automated computer-aided diagnosis system in dental clinics, automatic detection and identification of individual teeth from panoramic X-ray images are critical prerequisites. In this study, we propose a point-wise tooth localization neural network by introducing a spatial distance regularization

Information extracted from electrohysterography recordings could potentially prove to be an interesting additional source of information to estimate the risk on preterm birth. Recently, a large number of studies have reported near-perfect results to distinguish between recordings of patients that will deliver term or preterm using a public resource, called the Term/Preterm Electrohysterogram database

Context and background Corona virus (COVID) has rapidly gained a foothold and caused a global pandemic. Particularists try their best to tackle this global crisis. New challenges outlined from various medical perspectives may require a novel design solution. Asymptomatic COVID-19 carriers show different health conditions and no symptoms; hence, a differentiation process is required to avert the risk

Studies from the literature show that the prevalence of sleep disorder in children is far higher than that in adults. Although much research effort has been made on sleep stage classification for adults, children have significantly different characteristics of sleep stages. Therefore, there is an urgent need for sleep stage classification targeting children in particular. Our method focuses on two

Apart from the need for superior accuracy, healthcare applications of intelligent systems also demand the deployment of interpretable machine learning models which allow clinicians to interrogate and validate extracted medical knowledge. Fuzzy rule-based models are generally considered interpretable that are able to reflect the associations between medical conditions and associated symptoms, through

The segmentation of the mitral valve annulus and leaflets specifies a crucial first step to establish a machine learning pipeline that can support physicians in performing multiple tasks, e.g. diagnosis of mitral valve diseases, surgical planning, and intraoperative procedures. Current methods for mitral valve segmentation on 2D echocardiography videos require extensive interaction with annotators

According to functional or anatomical modalities, medical imaging provides a visual representation of complex structures or activities in the human body. One of the most common processing methods applied to those images is segmentation, in which an image is divided into a set of regions of interest. Human anatomical complexity and medical image acquisition artifacts make segmentation of medical images

Cardiac magnetic resonance quantitative T1-mapping is increasingly used for advanced myocardial tissue characterisation. However, cardiac or respiratory motion can significantly affect the diagnostic utility of T1-maps, and thus motion artefact detection is critical for quality control and clinically-robust T1 measurements. Manual quality control of T1-maps may provide reassurance, but is laborious

Notwithstanding advances in machine learning-based clinical prediction models, only few of such models are actually deployed in clinical contexts, among other reasons, for a lack of validation studies. In this paper, we present and discuss the validation results of a machine learning model for the prediction of acute kidney injury in cardiac surgery patients initially developed on the MIMIC-III dataset

Distant recurrence of breast cancer results in high lifetime risks and low 5-year survival rates. Early prediction of distant recurrent breast cancer could facilitate intervention and improve patients’ life quality. In this study, we designed an EHR-based predictive model to estimate the distant recurrent probability of breast cancer patients. We studied the pathology reports and progress notes of

Breast cancer is the most frequent cancer in women and the second most frequent overall after lung cancer. Although the 5-year survival rate of breast cancer is relatively high, recurrence is also common which often involves metastasis with its consequent threat for patients. DNA methylation-derived databases have become an interesting primary source for supervised knowledge extraction regarding breast

Background Slowness of movement, known as bradykinesia, is the core clinical sign of Parkinson's and fundamental to its diagnosis. Clinicians commonly assess bradykinesia by making a visual judgement of the patient tapping finger and thumb together repetitively. However, inter-rater agreement of expert assessments has been shown to be only moderate, at best. Aim We propose a low-cost, contactless system

Objective Optimizing timing of defibrillation by evaluating the likelihood of a successful outcome could significantly enhance resuscitation. Previous studies employed conventional machine learning approaches and hand-crafted features to address this issue, but none have achieved superior performance to be widely accepted. This study proposes a novel approach in which predictive features are automatically

Medicine is at a disciplinary crossroads. With the rapid integration of Artificial Intelligence (AI) into the healthcare field the future care of our patients will depend on the decisions we make now. Demographic healthcare inequalities continue to persist worldwide and the impact of medical biases on different patient groups is still being uncovered by the research community. At a time when clinical

Discovering new treatments and personalizing existing ones is one of the major goals of modern clinical research. In the last decade, Artificial Intelligence (AI) has enabled the realization of advanced intelligent systems able to learn about clinical treatments and discover new medical knowledge from the huge amount of data collected. Reinforcement Learning (RL), which is a branch of Machine Learning

Generative adversarial networks (GANs) and their extensions have carved open many exciting ways to tackle well known and challenging medical image analysis problems such as medical image de-noising, reconstruction, segmentation, data simulation, detection or classification. Furthermore, their ability to synthesize images at unprecedented levels of realism also gives hope that the chronic scarcity of

Healthcare organizations are confronted with challenges including the contention between tightening budgets and increased care needs. In the light of these challenges, they are becoming increasingly aware of the need to improve their processes to ensure quality of care for patients. To identify process improvement opportunities, a thorough process analysis is required, which can be based on real-life

A variety of deep learning architectures have been developed for the goal of predictive modelling and knowledge extraction from medical records. Several models have placed strong emphasis on temporal attention mechanisms and decay factors as a means to include highly temporally relevant information regarding the recency of medical event occurrence while facilitating medical code-level interpretability

This paper reports on research to design an ensemble deep learning framework that integrates fine-tuned, three-stream hybrid deep neural network (i.e., Ensemble Deep Learning Model, EDLM), employing Convolutional Neural Network (CNN) to extract facial image features, detect and accurately classify the pain. To develop the approach, the VGGFace is fine-tuned and integrated with Principal Component Analysis

Recently, several schemes are proposed for enhancing the dark regions of the skeletal scintigraphy image. Nevertheless, most of them are flawed by some performance problems. This paper presents an adaptive scheme based on Salp Swarm algorithm (SSA) and a neutrosophic set (NS) under multi-criteria to enhance the dark regions of the skeletal scintigraphy image efficiently. Enhancing the dark regions

Two algorithms for explaining decisions of a lung cancer computer-aided diagnosis system are proposed. Their main peculiarity is that they produce explanations of diseases in the form of special sentences via natural language. The algorithms consist of two parts. The first part is a standard local post-hoc explanation model, for example, the well-known LIME, which is used for selecting important features

Traditional Chinese Medicine (TCM) considers that the personal constitution determines the occurrence trend and therapeutic effects of certain diseases, which can be recognized by machine learning through tongue images. However, current machine learning methods are confronted with two challenges. First, there are not some larger tongue image databases available. Second, they do not use the domain knowledge

Deregulated splicing machinery components have shown to be associated with the development of several types of cancer and, therefore, the determination of such alterations can help the development of tumor-specific molecular targets for early prognosis and therapy. Determining such splicing components, however, is not a straightforward task mainly due to the heterogeneity of tumors, the variability

An electronic medical record (EMR) is a rich source of clinical information for medical studies. Each physician usually has his or her own way to describe a patient's diagnosis. This results in many different ways to describe the same disease, which produces a large number of informal nonstandard diagnoses in EMRs. The Tenth Revision of International Classification of Diseases (ICD-10) is a medical

Microarray gene expression profiling has emerged as an efficient technique for cancer diagnosis, prognosis, and treatment. One of the major drawbacks of gene expression microarrays is the “curse of dimensionality”, which hinders the usefulness of information in datasets and leads to computational instability. In recent years, feature selection techniques have emerged as effective tools to identify

Evidence-Based Medicine (EBM) has been an important practice for medical practitioners. However, as the number of medical publications increases dramatically, it is becoming extremely difficult for medical experts to review all the contents available and make an informative treatment plan for their patients. A variety of frameworks, including the PICO framework which is named after its elements (Population

Alzheimer's disease (AD) is now difficult to be identified for clinicians, especially, at its prodromal stage, mild cognitive impairment (MCI), because of no obvious clinical symptom and few impacts on daily life at this phase. In addition, energy distribution differences of brain atrophies reflected in structural magnetic resonance imaging (sMRI) images between MCI patients and older healthy controls

Frozen sections provide a basis for rapid intraoperative diagnosis that can guide surgery, but the diagnoses often challenge pathologists. Here we propose a rule-based system to differentiate thyroid nodules from intraoperative frozen sections using deep learning techniques. The proposed system consists of three components: (1) automatically locating tissue regions in the whole slide images (WSIs)

Colorectal cancer has a great incidence rate worldwide, but its early detection significantly increases the survival rate. Colonoscopy is the gold standard procedure for diagnosis and removal of colorectal lesions with potential to evolve into cancer and computer-aided detection systems can help gastroenterologists to increase the adenoma detection rate, one of the main indicators for colonoscopy quality

Diabetic retinopathy (DR) is the most common eye complication of diabetes and one of the leading causes of blindness and vision impairment. Automated and accurate DR grading is of great significance for the timely and effective treatment of fundus diseases. Current clinical methods remain subject to potential time-consumption and high-risk. In this paper, a hierarchically Coarse-to-fine network (CF-DRNet)

In a digitally enabled healthcare setting, we posit that an individual’s current location is pivotal for supporting many virtual care services—such as tailoring educational content towards an individual’s current location, and, hence, current stage in an acute care process; improving activity recognition for supporting self-management in a home-based setting; and guiding individuals with cognitive

Progress in proteomics has enabled biologists to accurately measure the amount of protein in a tumor. This work is based on a breast cancer data set, result of the proteomics analysis of a cohort of tumors carried out at Karolinska Institutet. While evidence suggests that an anomaly in the protein content is related to the cancerous nature of tumors, the proteins that could be markers of cancer types

Temporal phenotyping enables clinicians to better understand observable characteristics of a disease as it progresses. Modelling disease progression that captures interactions between phenotypes is inherently challenging. Temporal models that capture change in disease over time can identify the key features that characterize disease subtypes that underpin these trajectories. These models will enable

Objective In this paper, we proposed new methods for feature extraction in machine learning-based classification of atrial fibrillation from ECG signal. Methods Our proposed methods improved conventional 1-dimensional local binary pattern method in two ways. First, we proposed a dynamic threshold LBP code generation method for use with 1-dimensional signals, enabling the generated LBP codes to have

Automated skin lesion analysis is one of the trending fields that has gained attention among the dermatologists and health care practitioners. Skin lesion restoration is an essential pre-processing step for lesion enhancements for accurate automated analysis and diagnosis by both dermatologists and computer-aided diagnosis tools. Hair occlusion is one of the most popular artifacts in dermatoscopic

Automated detection of dynamical change in EEG signals has been a long-standing problem in a wide range of clinic applications. It is essential to extract an effective and accurate EEG rhythm indicator that can reflect the dynamical behavior of a given EEG signal. Time-frequency analysis is a promising method to achieve this end, but existing methods still have limitations in real implementation making

Nowadays, the demand for segmenting different types of cells imaged by microscopes is increased tremendously. The requirements for the segmentation accuracy are becoming stricter. Because of the great diversity of cells, no traditional methods could segment various types of cells with adequate accuracy. In this paper, we aim to propose a generic approach that is capable of segmenting various types

Machine learning (ML) approaches have been widely applied to medical data in order to find reliable classifiers to improve diagnosis and detect candidate biomarkers of a disease. However, as a powerful, multivariate, data-driven approach, ML can be misled by biases and outliers in the training set, finding sample-dependent classification patterns. This phenomenon often occurs in biomedical applications

Background Cancer remains the second major cause of death in the United States over the last decade. Chemotherapy is a core component of nearly every cancer treatment plan. Chemotherapy-Induced Nausea and Vomiting (CINV) are the two most dreadful and unpleasant side-effects of chemotherapy for cancer patients. Several patient-specific factors affect the risk of CINV. However, none of the guidelines

Electronic medical records (EMRs) contain a wealth of knowledge that can be used to assist doctors in making clinical decisions like disease diagnosis. Constructing a medical knowledge network (MKN) to link medical concepts in EMRs is an effective way to manage this knowledge. The quality of the diagnostic result made by MKN-based clinical decision support system depends on the accuracy of medical

The early detection of Alzheimer’s disease can potentially make eventual treatments more effective. This work presents a deep learning model to detect early symptoms of Alzheimer’s disease using synchronization measures obtained with magnetoencephalography. The proposed model is a novel deep learning architecture based on an ensemble of randomized blocks formed by a sequence of 2D-convolutional, batch-normalization

The DESIREE project has developed a platform offering several complementary therapeutic decision support modules to improve the quality of care for breast cancer patients. All modules are operating consistently with a common breast cancer knowledge model (BCKM) following the generic entity-attribute-value model. The BCKM is formalized as an ontology including both the data model to represent clinical

Objectives Lung cancer is the leading cause of cancer death worldwide. Prognosis of lung cancer plays a crucial role in the clinical decision-making process to optimize the treatment for patients. Most of the existing data-driven prognostic prediction models explore the relations between patient’s characteristics and outcomes at a specific time interval. Although valuable, they neglect the relations

Blood glycemic control is crucial for minimizing severe side effects in diabetes mellitus. Currently, two opposing treatment approaches exist: in formulaic methods, insulin care is calculated by parameter-based computation (i.e., correction factor, insulin-to-carb ratio, and absorption duration), which are fixed by the medical team based on the history of a tested patient blood glucose levels (BGLs)

Continuous blood pressure (BP) measurement is crucial for reliable and timely hypertension detection. State-of-the-art continuous BP measurement methods based on pulse transit time or multiple parameters require simultaneous electrocardiogram (ECG) and photoplethysmogram (PPG) signals. Compared with PPG signals, ECG signals are easy to collect using wearable devices. This study examined a novel continuous

Recognition of activities of daily living (ADL) is an essential component of assisted living systems based on actigraphy. This task can nowadays be performed by machine learning models which are able to automatically extract and learn relevant features but, most of time, need to be trained with large amounts of data collected on several users. In this paper, we propose an approach to learn personalized

Patients with advanced cancer are burdened physically and psychologically, so there is an urgent need to pay more attention to their health-related quality of life (HRQOL). With an expected clinical endpoint prediction, over-treatment can be effectively eliminated by the means of palliative care at the right time. This paper develops a deep learning based approach for cancer clinical endpoint prediction

Erythropoiesis Stimulating Agents (ESAs) have become a standard anemia management tool for End Stage Renal Disease (ESRD) patients. However, dose optimization constitutes an extremely challenging task due to huge inter and intra-patient variability in the responses to ESA administration. Current data-based approaches to anemia control focus on learning accurate hemoglobin prediction models, which can

Patients suffering from Barrett's Esophagus (BE) are at an increased risk of developing esophageal adenocarcinoma and early detection is crucial for a good prognosis. To aid the endoscopists with the early detection for this preliminary stage of esophageal cancer, this work concentrates on the development and extensive evaluation of a state-of-the-art computer-aided classification and localization

Healthcare industry is the leading domain that has been revolutionized by the incorporation of Internet of Things (IoT) technology resulting in smart medical applications. Conspicuously, this study presents an effective system of home-centric Urine-based Diabetes (UbD) monitoring system. Specifically, the proposed system comprises of 4-layers for predicting and monitoring diabetes-oriented urine infection

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Automated brain hematoma segmentation and outcome prediction for patients with TBI can effectively facilitate patient management. In this study, we propose a novel Multi-view convolutional neural network with a mixed loss to segment total acute hematoma on head CT scans collected within 24 h after the injury. Based on