Abstract The stiffness and gelation temperature of thermo-responsive chitosan (CS), glycerophosphate (GP) hydrogel is not enough for differentiation of BMSCs and injecting use in bone defect repair. To improve these weaknesses, a kind of injectable hydrogel (PMCG) was prepared with Chitosan (CS), glycerophosphate (GP), polygonatum polysaccharide modified montmorillonite (PMMT). The gelation temperature

Abstract The present study was aimed to develop chitosan-coated enamel adhesive device of CAP-P 407 (Cellulose acetate phthalate-Poloxamer 407), loaded with MNC (Minocycline) for sustained release and site-specific drug delivery system for the carious lesion. The average tensile strength and in-vitro drug release of uncoated dental film were found to be 15.97 kg/mm2 and 98.11% in 24 h, respectively

Abstract pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2–12 increased only with

Abstract Mussel-inspired bionics technology has attracted extensive attention for the surface modification of porous materials. The adhesion effect of the mussel mucin comes is mainly from hydroxylation. Hence, polysulfone membrane was modified by co-deposition of catechol with hydroxyl and L-lysine with biocompatibility. Flux of the membrane exceeds 120 L m−2 h−1, the ultra-high rejection rate to

Abstract Polymer and hydroxyapatite (HAP) composites have growing interest in bone regeneration. Commonly used for these applications is polyvinylpyrrolidone (PVP), which represents excellent biological inertness, is biocompatible, and do not adversely interact with HAP. For this reason, in our studies, we have focused on 3-igreedient biocomposites based on PVP/histidine/HAP investigating their mechanical

Abstract A new modified chitosan derivative (N-acetyl,N’-chitosanacetohydrazide, ACsAH) and its cobalt(II), nickel(II), manganese(II), and copper(II) complexes were successfully prepared. Their structures were proven using elemental analysis, FTIR, 1H-NMR and electronic spectroscopy, magnetic moment, and molar conductance. An octahedral stereochemistry for all the synthesized ACsAH–metal complexes

Abstract In the present study, to advance the skin tissue regeneration process, aspirin (AS)-loaded polycaprolactone (PCL) and maltodextrin (MD) composite nanofiber was prepared via electrospinning technique. The results showed that the composite had more uniform nanofibers and the mean diameter of the nanofibers was reduced from 186 to 96 nm experimentally with increasing AS percentages. Biological

Abstract In the past few years, research has focused on design and development of natural polymers-based hydrogels owing to their inherent features as well as numerous application ranges. In this context, polysaccharide-based hydrogels have attracted significant interest mainly due to their superior physicochemical and biological characteristics. However, these types of biomaterials ‘suffer’ from some

Abstract Common adversities as gastrointestinal discomfort are related to conventional administration of diclofenac potassium (DP), and thus the study of a new administration route based on gelatin/polycaprolactone electrospun nanofibers loaded with DP is an innovative way to create biomaterials for topical delivery of drugs aiming the patients’ life quality improvement. SEM-EDS evidenced success in

Abstract The aim of this study was to investigate the shear bond strength of composite resin to PEEK under hypobaric and hyperbaric pressure changes in different PEEK surface treatments. Ninety-six PEEK specimens were divided into three groups (n = 32). PEEK surfaces were sandblasted; acid-etched, and non-treated. Every group was then divided into three sub-groups (n = 10) for simulating hyperbaric

Abstract Polyhydroxyalkanoates (PHA) envisage a potential biomaterial alternative to replacing synthetic polymers for their biodegradability and biocompatibility. Modification approaches exploit the attributes and adjust the intrinsic hydrophobic properties, such as blending to produce a new polymer mix with novel properties. Functionalization of PHA, especially chemical grafting, perform to introduce

Abstract We present investigations of the structures and properties of the complex formed by a strong polyanion: poly-(sodium 4-styrene sulfonate) (PSSNa) and weak polycation: poly-L-ornithine (PLO) by combining dynamic light scattering (DLS), ultra-small-angle light scattering (USALS), turbidimetry, and zetametry techniques. The mixtures of polyelectrolytes were controlled in several ways: by the

Abstract Emerging novel approaches for bone tissue regeneration and engineering are based on bioactive materials scaffolding architectures for mimicking naturally occurring extracellular matrix while also acting as structural platform for cells attachment, multiplication, migration as well as functionalization. Polymeric nano-biocomposites formed from organic/inorganic hybrid biomaterials constructed

Abstract The microporous films comprised of chitosan (CS), gelatin (Gel) and magnesium oxide nanoparticles (MgO NPs) were developed as a wound-healing material using the lyophilization technique. The chemical structure, composition and morphology of the films were evaluated by FTIR, XRD, EDX and SEM. Also, the swelling, mechanical, biodegradation, cell viability, antimicrobial property, bioactivity

Abstract Bilayer wound dressing systems consisting of various biopolymers have been preferred in biomedical applications due to its enhanced advantages in comparison with conventional systems. The aim of this research was to develop a novel bilayer wound dressing based on gelatin (G) and gellan gum (GG). The bilayer was composed of an upper layer impregnated with antibiotic drug sodium ampicillin and

Abstract Combination therapy has been designed to overcome the setbacks of traditional chemotherapy in anticancer therapy. Since combination therapy comprises a combination of anticancer agents, the different pharmacokinetics and biodistribution properties of multiple drugs are the primary concern. Stimuli-responsive polymers can vary in structure with changes in environmental conditions. Therefore

Abstract Bacterial infection is a serious threat to human health. In this work, carbon dots (CDs) based on the polyethyleneimine (PEI) was prepared by hydrothermal carbonization method and then reacted with nitric oxide (NO) to form the NO-loaded CDs (CD-PEI/NONOate). CD-PEI/NONOate showed a high NO payload and outstanding fluorescence characteristics. It was found that CD-PEI/NONOate could inhibit

Abstract A nano-hydroxyapatite/chitosan (n-HA/CS) scaffold loading with CS microspheres was developed in this study. First, CS microspheres with an average diameter of ∼57 μm were prepared by cross-linking, and a three-dimensional (3D) printing technology was used to fabricate n-HA/CS porous scaffolds with an average pore size and porosity of 454 ± 51 μm and 60.71%, respectively. Then, the n-HA/CS

Abstract The ethanolamine-modified polylactide (ETA-PLLA) nanofibrous microsphere was fabricated by emulsification combine with a thermally induced phase separation method. The drug loading density of loxoprofen Sodium was 11.5%, the drug loading density of ibuprofen was 2.25%, which should be attributed to the hydrophilic of ETA-PLLA. The nanofibrous injectable microspheres have a slow release effect

Abstract pH and GSH dual-responsive nanoparticles with fluorescence detection were successfully prepared from the polydopamine coating on the surface of mesoporous silica via disulfide bonds (MSN-SS-PDA). The average diameter of nanoparticles was about 80–100 nm with a well-ordered mesoporous structure. The outer layer of PDA was about 10.0 nm acting as a pH and GSH sensitive gatekeeper to control

Abstract This study aimed to manufacture a new pH-responsive hydrogel based on 2-(N, N′-dimethylamino ethyl methacrylate) DMAEMA and chitosan CS by the impact of gamma radiation which introduces high sensitivity to the variation in the pH of the medium depending on the composition of DMAEMA/CS. The highest swellable DMAEMA/CS composition was used as a precursor for the preparation of a magnetic counterpart

Abstract Wounds affect various functions of the skin, and treating them has always been a challenge for humans. Skin grafts have been traditionally used to treat wounds; however, they have certain shortcomings. Skin tissue engineering has many advantages, and thus, it is expected to become a new method for wound treatment. Suitable skin substitutes are necessary for skin tissue engineering, and the

Abstract A new MoS2/Fe3O4 dendrimer grafted polystyrene (PST)/poly(N-vinylcaprolactam) (PNVCL) was prepared as a temperature-sensitive nanocomposite for adsorption and controlled release of sertraline. The maximum adsorption capacity of nanocomposite for sertraline was about 5.24 mgg−1 under optimum pH of 8, equilibrium time of 30 min and adsorbent dosage of 5 gL−1. The kinetic of sertraline sorption

Abstract Increasing efforts have been focused on development of novel therapeutic approaches based on a carrier mixed with polymeric microparticles (MPs) for promoting bioactive factors delivery. Polymers as poly (lactide-co-glycolide) are the most widely used due to their tunable physico-chemical properties and biomimetic character. Here, PLGA-MPs of different surface charges were dispersed in hyaluronic

Abstract Polylactic acid (PLA), one of the well-known bioabsorbable and compostable polyesters has rapidly evolved into a competitive commodity material over the last decades. To provide efficient therapy for the biomedical application domain understanding the PLA properties is the key tenets to achieve suitable chemical and biological properties. In most instances, PLA can be blended or copolymerized

Abstract Poly(catechin) (p(CAT)) nanoparticles (NPs), 173 ± 4 nm was prepared as a therapeutic agent with hydrolytic degradability affording sustainable CAT release over 20 d at carcinogenic conditions, pH 5.5 and 37.5 °C. Cell viability studies on MC38 colon cancer cells revealed the anticancer potential of p(CAT) NPs with 691 µg/mL IC50 value while being well-tolerated by nonmalignant CCD841 CoN

Abstract Shape memory polyurethane (SMPU)/graphene quantum dot nanoparticles (GQDs) nanofibers were prepared by electrospinning technique. Results show that the localization of GQD nanoparticles into the nanocomposite electrospun nanofibers has increased the nanofiber average diameter. An increment has been observed in the mechanical strength of nanocomposite nanofiber mats. More uniform and straight

Abstract Nanosponges, porous nanocarriers were explored for encapsulation of carboplatin by employing a quality by design approach. Nanosponges were prepared by double emulsion solvent evaporation using the central composite design. Ethylcellulose, 450 mg, polyvinyl alcohol, 2.3% (w/v) and phase evaporation rate, 760 rpm yielded the optimized spherical particles of size 272.92 ± 12.31 nm, PDI 0.390

Abstract Two new hydrogels have been synthesized by incorporating terephthalohydrazido linkages into chitosan Schiff base (TCsSB) and chitosan (TCs). They swell at pH 4 more than at pH 9 and 7. TCs has a higher activity against most of the tested microbes as indicated from its lower MIC values than that measured by the reference drugs Vancomycin and Amphotericin B. Evaluation of the cytotoxicity impacts

Abstract With the development of peripheral nerve tissue engineering, study of biodegradable materials have extensive applied prospect. Chitosan (Cs) is a promising candidate for neural tissue engineering due to its similar chemical structure to glycosaminoglycan. However, due to its lack of elasticity and flexibility, Cs often needs to be used in combination with other materials. In this study, three

Abstract There is a need to find alternative solvents for electrospinning that are less hazardous and more environmentally safe than the Class II solvents currently used. We characterized poly(lactic-co-glycolic acid) (PLGA) nanofibers (NFs) electrospun using a new, less toxic solvent system comprised the Class III solvents acetone:ethyl acetate (ACE:EtAc). Both solvent systems produced amorphous NFs

Abstract pH-sensitive magnetic dual drug-loaded microcapsules (MDDM) embracing magnetic nanoparticles Fe3O4@SiO2 and two drugs (roxithromycin (ROX) and theophylline (TH)) were prepared through self-assembly, with methylcellulose and alginate sodium as the wall materials. MDDM was characterized with FTIR, XRD, TGA, vibrating sample magnetometer. The amount of Fe3O4@SiO2 affected the drug encapsulation

Abstract Surface properties of octavinyl polyhedral oligomeric silsesquioxane (OVS), grafted polyurethane (PU) and heparinized carbon nanotubes (HCNTs) nanocomposite thin-films were evaluated, and the effect of OVS presence on platelet adhesion on the surface of nanocomposite films for artificial heart valve application was investigated using in-vitro tests. OVS was synthesized, then PU and CNT (PU/CNT)

Abstract In this work, we analyze the thermoresponsive behavior of scaffolds prepared from dioctyl fumarate-N-isopropylacrylamide copolymers (DFN) with different compositions. Lower critical solution temperature (LCST) of these biomaterials was determined by differential scanning calorimetry (DSC) and transmittance measurement, finding that LCST increase when the content of fumaric monomer increase

Abstract S-nitroso-N-acetylpenicillamine (SNAP) and hydrophobic succinyl pyrene (SuPy) were conjugated to hyaluronic acid (HA) through cystamine dihydrochloride (Cys) linkers to synthesize NO-conjugated reductive–responsive prodrugs HA-Cys-(SNAP/SuPy). The prodrug could self-assemble into spherical micelles with a particle size of <200 nm. In a reductive environment (10 mM dithiothreitol, DTT), a substantial

Abstract Titanium-based biomaterials are among the most extensively used implants in orthopedics and dentistry. However, their poor osteoconductivity and osteoinductivity are the main challenges for researchers, so the existence of other components with the aim of overcoming the mentioned deficiencies could be desirable. In the present research, a bioactive nanofibrous coating of polyvinyl alcohol-sericin

Abstract Here, Fe3O4 @SiO2 @Poly (DEMA -EGDMA-CO-VPBA) nanoparticles were prepared as a pH-sensitive nanocomposite for adsorption and controlled release of glycoproteins. The average size of particles was found to be 62.5 nm. The ability of these particles to isolate and enrich the glycoprotein Horseradish Peroxidase and nonglycoprotein of Bovine serum was investigated using analytical and spectroscopic

Abstract Small diameter vascular grafts are frequently used in the treatment of cardiovascular diseases. The aim of this study is to design electrospun telmisartan (TEL)-loaded polycaprolactone/gelatin (GEL) based vascular scaffold prototypes. A series of drug-free and TEL-loaded scaffolds were electrospun. When best formulations considered, mean fiber diameters were found as 1,133 and 1,120 nm, contact

Abstract The nonspecificity of doxorubicin (DOX), as well as its oral bioavailability, is a major obstacle in the clinical setting. This study was based on the change of pH value and designed for the 1st time a novel nano-matrix; multiwall carbon nanotubes (MWCNTs) coated with mesoporous silica (MS) and chitosan (CS). The latter possessed a unique nanostructure with pH-sensitivity in DOX release to

Abstract In this work, hydrogels with antimicrobial activity based on the polysaccharide maltodextrin (MD) were prepared by copolymerization with either acrylic acid (AAc) or acrylamide (AAm) to endow chemical functionality to host zinc oxide nanoparticles (ZnO). MD was previously modified with glycidyl methacrylate (GMA) in order to be susceptible to react with these monomers through free radical

Abstract Diabetic wounds are very problematic wounds that have a high risk of infection. The healing process of wounds in diabetic patients is more complicated than others. Wound dressing preparation is one of the promising treatment modalities for repairing damaged tissues in diabetic patients. The aim of this study is to demonstrate the antibacterial effects of drug release of clarithromycin from

Abstract The growing trend of bone disorders often caused by accidental injury coupled with aging increasing aging population demands more effective therapeutic intervention. Bone tissue engineering is considered a unique method that provides functional bone grafts by combining biomaterial, cells, and signaling factors and can be a promising alternative to the conventional bone grafts used for bone

Abstract Cell carriers such as chitosan, alginate and cellulose play a crucial role in cell behavior, however the influence of their chemical nature on osteogenesis is little studied. Here, rat bone marrow cells were grown on the surface of those polymers. The cells remained viable and produced a mineral matrix, which was deposited on the surface of all the polymers. The amount of inorganic matrix

Abstract The aim of this study is to develop hemoglobin (hb) encapsulated self-assembled polymer for use as artificial oxygen carrier. Methoxy-polyethylene glycol (mPEG45) block and poly (ɛ-caprolactone [ɛ-CL]) (mPEG-b-PCL) that formed diblock copolymer was synthesized via ring-opening polymerization (ROP). Extracted and purified hb was then encapsulated in polymer with critical micelle concentration

Abstract PDMS is the most widely used material in the microfluidic systems because of its advantageous properties including ease of manufacture, low cost, transparency, and gas permeability. Although all biomaterials need to be sterilized for usage for in vitro or in vivo systems to avoid possible contaminants, none of them proved effective in providing the gold standards so far for PDMS sterilization

Abstract In this work, we fabricated scaffolds for epithelial cell differentiation based on functional fibers. Chitosan, PCL, and PLLA composite scaffolds were electrospun under two controlled atmospheres. SEM results have shown yarns (<300 nm), strings (∼500 nm), and ribbons (∼2 µm). DSC and TGA indicate the main melting temperature ∼61 °C and a degradation temperature at 277 °C. Aqueous swell and

Abstract The work describes a polydopamine-wrapped zeolitic imidazolate framework-8 (ZIF-8) coating constructed on the sulfonated polyetheretherketone (PEEK). The coating is not only conducive to the controllable Zn2+ releases, but also exhibits excellent photothermal capacity under near-infrared (NIR) irradiation. in vitro antibacterial experiments indicate the coating possesses bactericidal efficiencies

Abstract Purpose 2-(10,11-Dihydro-10-oxodibenzo [b,f] thiepin-2-yl) propionic acid (Zaltoprofen) is classified as a BCS class II anti-inflammatory drug, having low solubility and less bioavailability. Methods This study describes the development and characterization of self-micro emulsifying drug delivery system (SMEDDS) of the poorly water-soluble compound Zaltoprofen that resulted in improved aqueous

Abstract Blindness of the cornea is the major cause of blindness globally. Many approaches and strategies have been developed to replace or regenerate damaged cornea. Different biomaterials like biopolymeric hydrogels with excellent mechanical & physical properties have been used for the regeneration of corneal tissue. In this review, we focused on using the different types of hydrogels throughout

Abstract Glycopolymers are multifunctional bio-mimetic supramolecules that can emulate the functions of glycopeptides. Entitled to molecular recognition, these molecules appertain to amplify the original bio-molecular interactions with lectins. It is ubiquitous that glycopolymers offer the potential to be explored for targeted drug delivery and tumor cell treatment, unfolding new dawn in tissue engineering

Abstract In this work, bionanocomposite membranes of hydroxyapatite nanoparticles (nHA) embedded in chitosan (CHI) or carboxymethyl-chitosan (CMC) matrices were chemically crosslinked with epichlorohydrin (ECH) for tuning their physicochemical and biological properties aiming at bone tissue regeneration. The choice of CHI or CMC biopolymer, as well as the presence of ECH crosslinker, affected the nucleation

Abstract In this study, diopside coated Poly-L-lactic acid-based (PLLA/Diopside) and Poly-L-lactic acid along with pluronic acid (PLLA-P123/Diopside) scaffolds were fabricated by electrospinning to improve the drawbacks with pure polymer and pure bioceramic scaffolds in bone tissue engineering application. The surface morphology, hydrophilicity, and mechanical strength were evaluated. The cell proliferation

Abstract To achieve biocompatibility and high gene transfection efficiency, developing new cationic polymers with natural functional moieties has been regarded as a promising way. In this work, histidine was grafted on chitosan (CS) to produce CS derivatives (HGCS) for siRNA delivery and the HGCS/siRNA complexes were formed by the self-assembly method. The structures of histidine grafted CS polymers

Abstract Formulation and characterization of Luliconazole (LZL) nanosuspensions using modified starch ester polymer to increase solubility. X-ray analysis of A6 and B4 lyophilized nanosuspensions confirmed amorphous nature having % relative crytalinilty of 48.453, 41.374% and crystallite size of 21 and 35 nm; respectively. However, solubility of lyophilized nanosuspension improved by more than 370

Abstract In this study, injectable peptide hydrogels were designed and fabricated based on the crosslinking of peptides and hyaluronic acid (HA) by 1,4-butanediol diglycidyl ether (BDDE). An anticancer bioactive peptide (ACBP), plant peptide (PB), fishbone collagen (FBC), and bovine bone collagen (BBC) were incorporated as peptide sources to assess their characteristics. The peptide hydrogels form

Abstract With the objective of developing a localized gentamicin sulfate (GS) delivery system with a controlled release kinetics for the prevention/management of osteomyelitis, composite electrospun fibers composed of poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) blends and GS loaded mesoporous silica nanoparticles (npSiGS) were prepared (PLA/PLGA: 1:3, 1:1, 3:1 w/w). GS was loaded

Abstract In this study, soybean protein nanoparticles (SPN) modified poly(hydroxybutyrate) (PHB) electrospun nanofiber scaffold is fabricated by a facile two-step method combination of PHB electrospinning and SPN evaporation-induced self-assembly. The surface characteristics, structure and properties are investigated by SEM, EDS, XPS, FTIR, XRD, DMA, WCA, tensile test and water uptake capacity measurements

Abstract Functionalized latex particles (FLP) are normally applied for diagnosis and therapeutics purposes and, in particular, the interest in colored FLP is rising in areas such as biomedical and research. The synthesis, characterization and application of FLP with a new colored monomer is here considered, in a simple and fast manner, and at low cost. Synthesis variables were controlled to obtain

Abstract Mechanically enhanced poloxamer (F127)-based injectable hydrogels in the presence of hyaluronic acid (HA) and three types of cyclodextrin (CD) molecules were prepared. With the addition of HA to the F127 system, higher strain values to break down the interactions between the micelles were obtained. The formulations exhibit more frequency-dependent behavior than F127–HA gels with the inclusion

Abstract Although amorphous calcium phosphate has been a mature research object in the medicine field, its application in drug carriers remains restricted due to its easy agglomeration and poor dispersion stability. Accordingly, the ACP was modified with hyaluronic acid (HA) and hexametaphosphate ((NaPO3)6), the amorphous structure can be kept for more than 3 months based on HA stabilizers, the dispersion