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Chrysanthemum coronarium L. Extract Attenuates Homocysteine-Induced Vascular Inflammation in Vascular Smooth Muscle Cells. J. Med. Food (IF 2.4) Pub Date : 2023-11-27 Ae Sin Lee,Yiseul Kim,Haeng Jeon Hur,Sang-Hee Lee,Mi Jeong Sung
Hyperhomocysteinemia is a main risk factor for phenotypic modulation of vascular smooth muscle cells (VSMCs) and atherosclerosis. Phenotypic switching and proliferation of VSMCs are related to the progression of vascular inflammation. Chrysanthemum coronarium L. is a leafy vegetable with various biological functions, such as antioxidative, anti-inflammatory, and antiproliferative effects. In this study
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Corydalis yanhusuo Polysaccharides Ameliorate Chronic Stress-Induced Depression in Mice through Gut Microbiota-Derived Short-Chain Fatty Acid Activation of 5-Hydroxytryptamine Signaling. J. Med. Food (IF 2.4) Pub Date : 2023-11-21 Yu Fang,Yanqing Li,Xin Liao,Jie Deng,Qiannan Wang,Jingtao Liang,Bohua Yan
Depression, a prevalent psychiatric disorder, presents a serious health risk to humans. Increasing evidence suggested that the gut microbiota and the 5-hydroxytryptamine (5-HT) pathway both contribute significantly to depression. This research aimed to investigate how Corydalis yanhusuo polysaccharides (CYP) could potentially alleviate depression induced by chronic unpredictable mild stress in mice
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Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomics Analysis of Indigo Naturalis Treatment of Ulcerative Colitis in Mice. J. Med. Food (IF 2.4) Pub Date : 2023-11-21 Anqi Fan,Bao-Long Hou,Zhishu Tang,Ting Wang,Dongbo Zhang,Yanni Liang,Zheng Wang
Ulcerative colitis (UC), often known as UC, is an inflammatory disease of the intestines that has frequent and long-lasting flare-ups. It is unknown precisely how the traditional Chinese drug Indigo Naturalis (IN) heals inflammatory bowel disease, despite its long-standing use in China and Japan. Finding new metabolite biomarkers linked to UC could improve our understanding of the disease, speed up
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Unripe Pear Extract Suppresses UVB-Induced Skin Photoaging in Hairless Mice and Keratinocytes. J. Med. Food (IF 2.4) Pub Date : 2023-11-21 Jeongjin Park,Dakyung Kim,Minhee Lee,Geum Duck Park,Soo Ro Kim,Yanxiu Jiang,Woojin Jun,Ok-Kyung Kim,Jeongmin Lee
Our study aimed to investigate whether unripe pear extract (UP) could provide protection against UVB-induced damage to both mouse skin and keratinocytes. We observed that UVB exposure, a common contributor to skin photoaging, led to wrinkle formation, skin dryness, and inflammation in mice. Nevertheless, these effects were mitigated in the groups of UVB-irradiated mice treated with UP. Moreover, UP
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Synergistic Effect of Madecassoside and Rosmarinic Acid Against Ultraviolet B-Induced Photoaging in Human Skin Fibroblasts. J. Med. Food (IF 2.4) Pub Date : 2023-11-17 Minha Kim,Huijin Heo,Seonghwa Hong,Junsoo Lee,Hana Lee
Madecassoside (MD) and rosmarinic acid (RA) are well-known compounds with wound healing and antiaging effects. We demonstrated the synergistic protective activity of the MD-RA combination in Hs68 cells against ultraviolet B (UVB)-induced photoaging. The cell viabilities of MD, RA, and MD-RA combinations at various ratios (9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8, and 1:9, v/v) were measured to compare
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Hippophae rhamnoides Prevents Oleic Acid-Induced Acute Respiratory Distress Syndrome by Releasing Acetylcholinesterase Activity and Mitigation of Angiotensin-Converting Enzyme Level. J. Med. Food (IF 2.4) Pub Date : 2023-11-17 Kubra Koc
Hippophae rhamnoides exhibit a wide variety of medicinal and pharmacological effects. The present study aims to determine the role of ethanol extract of H. rhamnoides on oleic acid (OA)-induced acute respiratory distress syndrome (ARDS) in rats. Male rats were randomly divided into the following groups: (I) Control, (II) OA, and (III) OA+H. rhamnoides. H. rhamnoides extract (500 mg/kg) was given orally
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Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels. J. Med. Food (IF 2.4) Pub Date : 2023-11-15 Wei Li,Beverly Spray,Elisabet Børsheim,Soheila Korourian,Reza Hakkak
The health benefits of soy foods are attributed to the high-quality protein and the bioactive compounds such as isoflavones. We previously reported that feeding obese (fa/fa) Zucker rats soy protein concentrates (SPCs) with low isoflavone (LIF) and high isoflavone (HIF) for 9 weeks significantly reduced liver steatosis compared to a casein control (C) diet. The current study extended the dietary treatments
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The Short-Term Effect of Olive Oil Extract Enriched with Hydroxytyrosol on Cardiovascular Function. J. Med. Food (IF 2.4) Pub Date : 2023-11-15 Nikolaos Iakovis,Ignatios Ikonomidis,Ioanna Andreadou,Αndrew Xanthopoulos,Aikaterini Chamaidi,Nikolaos Chrysakis,Grigorios Giamouzis,John Skoularigis,Ioulia Tseti,Filippos Triposkiadis
Olive is rich in polyphenols such as hydroxytyrosol (HT) that have antioxidative and anti-inflammatory effects. In this study, we examined the short-term effects of olive oil extract (OE) enriched with HT on left atrial function, left ventricular (LV) function, and arterial elastic properties in patients with chronic coronary artery disease (CAD). Sixty-one patients with chronic CAD were enrolled.
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Savory Cracker Development for Blood Glucose Control and Management: Glycogen Storage Diseases. J. Med. Food (IF 2.4) Pub Date : 2023-11-15 Xin Qi,Minh N Ta,Richard F Tester
The blood glucose response of savory slow energy-release crackers (GLY-HYP) were evaluated in volunteers carrying glycogen storage diseases (GSDs), Types I (Ia) and IV. The crackers have been shown previously to provide a "flat" slow glucose response in healthy volunteers, for up to 4 h. On average for the mixed-sex volunteer group aged 53 to 70 for Type I, the blood glucose concentration increased
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Edible Red Seaweed Hypnea asiatica Ameliorates High-Fat Diet-Induced Metabolic Diseases in Mice. J. Med. Food (IF 2.4) Pub Date : 2023-11-01 Shigeru Murakami,Chihiro Hirazawa,Toshiki Mizutani,Takuma Ohya,Rina Yoshikawa,Ning Ma,Takahiko Ikemori,Takashi Ito,Chiaki Matsuzaki
Metabolic diseases, including obesity, diabetes, and fatty liver disease, are dramatically increasing around the world. Seaweed is low in calories and rich in many active ingredients that are necessary for maintaining good health, and is expected to be effective for preventing metabolic diseases. The purpose of this study was to examine the effects of a traditional Japanese edible seaweed Hypnea asiatica
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Assessment of In Vitro Airway Smooth Muscle Relaxant Activity of Rhus coriaria L. Fruit Ethanolic Extract and Its Possible Mechanisms. J. Med. Food (IF 2.4) Pub Date : 2023-10-30 Albina Uka,Donjeta Krasniqi,Giangiacomo Beretta,Armond Daci
Rhus coriaria L. (Anacardiaceae), also known as Sumac, is commonly used as a spice, flavoring agent, and as a traditional medicinal herb. This includes also the traditional use for treating asthma, catarrh, and common colds. The accumulating evidence supports its cardioprotective, antidiabetic, neuroprotective, anticancer, gastroprotective, antibacterial, anti-inflammatory, antiviral, antioxidant,
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Gastroprotective Role of Fruit Extracts in Gastric Damage Induced by Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review. J. Med. Food (IF 2.4) Pub Date : 2023-10-30 Mariana Garrido-Valdes,Leonor Díaz-Velis,Marisela Valdes-Gonzalez,Barbara B Garrido-Suárez,Gabino Garrido
The aim of this study was to systematically review the scientific literature, with Preferred Reporting Items of Systematic Reviews and Meta-analyses (PRISMA) guidelines, of the articles found in the past 11 years on the gastroprotective role of fruit extracts in gastric ulcers induced by non-steroidal anti-inflammatory drugs (NSAIDs). Scientific articles published between 2010 and 2020 were included
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Wild Rosa roxburghii Tratt Juices Grown at Different Altitudes Regulate Blood Glucose in Type 1 Diabetic Mice via the PI3K/Akt Pathway. J. Med. Food (IF 2.4) Pub Date : 2023-10-27 Yuping Zhu,Suzhen Zhai,Bei Li,Ziyi Zhao,Jiao Xie,Tingyuan Ren
To explore hypoglycemic effect of wild Rosa roxburghii tratt (RRT) juice at different altitudes on type 1 diabetes mellitus (T1DM). The T1DM mouse model was induced by streptozotocin (STZ), and the experiment included a normal group (NC), model group (MC), wild RRT juice groups high (HF), medium (MF), low altitude (DF) and cultivated control group (PC). During experiment, food intake, water intake
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Effects of Walnut-Rich Diet on Cation-Handling Proteins in the Heart of Healthy and Metabolically Compromised Male Rats. J. Med. Food (IF 2.4) Pub Date : 2023-10-27 Snezana Tepavcevic,Snjezana Romic,Manja Zec,Tijana Culafic,Mojca Stojiljkovic,Tamara Ivkovic,Marija Pantelic,Milan Kostic,Jelena Stanisic,Goran Koricanac
The transport of cations in the cardiomyocytes, crucial for the functioning of the heart, can be affected by walnut diet due to the high content of polyunsaturated fatty acids. Healthy and metabolically compromised rats (drinking 10% fructose solution) were subjected to a diet supplemented with 2.4 g of walnuts for 6 weeks to investigate the effect on proteins involved in cation transport in the heart
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Soy Sauce Lowers Body Weight and Fat Mass in High-Fat Diet-Induced Obese Rats. J. Med. Food (IF 2.4) Pub Date : 2023-10-20 Eun-Ji Lee,Jeongwoo Song,Chan-Ho Park,Eun-Gyung Mun,Jinxi Wang,Anna Han,Jung Eun Park,Youn-Soo Cha
Soy sauce (SS) is a traditional fermented seasoning. Although fermented foods have diverse health beneficial effects, SS intake has been discouraged because of its high salt level. This study was designed to evaluate the antiobesity outcomes of SS and the potential involvement of salt content in SS by adding a high-salt group. Sprague-Dawley rats were randomly assigned into four groups: normal diet
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Supplementation with Ashitaba (Angelica keiskei) Yellow Stem Exudate Prevents Aging-Induced Thrombotic Tendencies and Systemic Inflammation Without Affecting Body Weight Gain in Mice. J. Med. Food (IF 2.4) Pub Date : 2023-10-20 Naoki Ohkura,Riyo Morimoto-Kamata,Katsutaka Oishi,Sayaka Higo-Yamamoto,Aya Fujinami,Ken-Ichi Inoue,Mitsuhiro Ohta
Angelica keiskei Koidzumi (Ashitaba) is a traditional folk medicine and health supplement in Japan. Ashitaba yellow stem exudate (AYE) contains abundant chalcones and thus has the potential to treat and prevent many pathological states such as cancer, inflammation, obesity, diabetics, thrombosis, and hypertension. Levels of plasminogen activator inhibitor 1 (PAI-1), a key regulator of the fibrinolytic
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Hydrolyzed Collagen Tripeptide Promotes Longitudinal Bone Growth in Childhood Rats via Increases in Insulin-Like Growth Factor-1 and Bone Morphogenetic Proteins. J. Med. Food (IF 2.4) Pub Date : 2023-10-20 Kang Hyun Leem,Sanga Kim,Junsik Lim,Hae Jeong Park,Yong Chul Shin,Joong Su Lee
Previous studies have reported that collagen tripeptide (CTP) derived from collagen hydrolysate has various beneficial effects on health by protecting against skin aging and improving bone formation and cartilage regeneration. Collagen-Tripep20TM (CTP20), which is a low-molecular-weight CTP derived from fish skin, contains a bioactive CTP, Gly-Pro-Hyp >3.2% with a tripeptide content >20%. Herein, we
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Sipping as a Nutritional Supplement in Ambulatory Palliative Oncology Care: A Pilot Study with Noninvasive Methods. J. Med. Food (IF 2.4) Pub Date : 2023-10-13 Alena Ticha,Radomir Hyspler,Veronika Molnarova,Peter Priester,Adela Tomasova,Stanislav Filip
Objective: The implementation of nutritional support is a basic need of patients in palliative oncological care. This pilot study optimized the use of sipping to improve the nutritional status of cancer patients in palliative care. Materials and Method: The pilot study included 63 patients, 61.3 years of age on average (range: 32-82 years of age). The patients were assigned to either group A (no nutritional
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Antidiabetic Effect of Combined Leaf Extracts of Portulaca oleracea L., Beta vulgaris L., and Cichorium intybus L. in Streptozotocin-Induced Diabetic Rats. J. Med. Food (IF 2.4) Pub Date : 2023-10-06 Shahinaz Ahmed Helmy,Nashwa Fathy Sayed Morsy,Shahenda Mohamed Elaby,Mohammed Abdel Hameed Awad Ghaly
Purslane (P), chard (CHA), and chicory (CHI) leaf extracts are individually and traditionally used in the treatment of diabetes mellitus. Polyphenols, flavonoids, the polyphenolic profile of the extracts, and their antioxidant activity were determined. This study evaluated the antidiabetic activity of combinations of these extracts in streptozotocin-induced diabetic rats. Diabetic groups were administered
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Effect of Blackberry Juice Consumption by Pregnant Rats on Brain Length and Cell Density of Dentate Gyrus in Male Wistar Pups. J. Med. Food (IF 2.4) Pub Date : 2023-10-04 Sigrid Mariel Ruiz-Martínez,Rosa Isela Guzmán-Gerónimo,Mayvi Alvarado-Olivarez,Isela Santiago-Roque,José Antonio Palma-Jacinto
The aim of this work was to evaluate the effect of blackberry juice consumption during pregnancy on the length of the brain, as well as on the cell density of the dentate gyrus in Wistar rat pups. Pregnant rats were divided into three groups: control (C), fed with standard diet and water ad libitum; BJ1, which received blackberry juice containing polyphenols (7.8 mg/kg) and anthocyanins (1.9 mg/kg);
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Pomegranate-Derived Exosome-Like Nanovesicles Alleviate Binge Alcohol-Induced Leaky Gut and Liver Injury. J. Med. Food (IF 2.4) Pub Date : 2023-09-21 Ji-Su Kim,Dong-Ha Kim,Myung-Chul Gil,Hyo-Jung Kwon,Wonhyo Seo,Do-Kyun Kim,Young-Eun Cho
Alcoholic liver disease (ALD) is damage to the liver and mainly caused by binge alcohol. ALD have decreased junctional protein expression and modulated intestinal permeability. We investigated whether plant-releasing exosome-like nanovesicles can prevent liver damage and leaky gut from binge alcohol. In this study, we characterized the exosome-like nanovesicles from pomegranate juice and confirmed
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Piperine as a Potential Nutraceutical Agent for Managing Diabetes and Its Complications: A Literature Review. J. Med. Food (IF 2.4) Pub Date : 2023-09-20 Yujie Wang,Shan Xu,Lidan Tang,Jinhong Gong,Dan Su,Hao Yang
The global prevalence of diabetes and its related complications has increased drastically and is currently a worldwide health challenge. There is still an urgent need for safe and effective natural products and supplements as alternative and/or adjunctive therapeutic interventions. Nowadays, people pay more and more attention to the nutritional and medicinal value of food ingredients. As one of the
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Unraveling the Potential Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Mechanisms of Ginger by Computational Target Fishing. J. Med. Food (IF 2.4) Pub Date : 2023-09-08 ShaoJun Chen,LiHua Zhang
Ginger (Zingiber officinale) is one of the most commonly consumed botanical foods. Owing to its anti-inflammatory and antiviral properties, ginger has been widely used as a homemade remedy during the corona virus disease 2019 (COVID-19) pandemic; however, the mechanisms of its therapeutic activities against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain obscure. In this study,
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C-Phycocyanin: A Phycobiliprotein from Spirulina with Metabolic Syndrome and Oxidative Stress Effects. J. Med. Food (IF 2.4) Pub Date : 2023-09-01 Van D Castro-Gerónimo,Rosa Virginia García-Rodríguez,Alberto Sánchez-Medina,German A Chamorro-Cevallos,Dolores Javier Sánchez-González,Enrique Méndez-Bolaina
Spirulina maxima is a cyanobacterium considered a "superfood" due to its metabolites and nutrient content. These include a complex mixture of minerals, vitamins, fatty acids, proteins, and accessory pigments. In recent years, it has positioned itself as a promising source of bioactive molecules for the treatment of several diseases, including metabolic syndrome, coronary diseases, cancer, and the improvement
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Controlling Intestinal Infections and Digestive Disorders Using Probiotics. J. Med. Food (IF 2.4) Pub Date : 2023-08-30 Sanjeev Kumar,Md Faruque Ahmad,Priyakshi Nath,Rubina Roy,Rudrarup Bhattacharjee,Eman Shama,Indira Gahatraj,Manisha Sehrawat,Vaishali Dasriya,Harmeet Singh Dhillon,Monica Puniya,Mrinal Samtiya,Tejpal Dhewa,Rotimi E Aluko,Gulab D Khedkar,António Raposo,Anil Kumar Puniya
After consumption, probiotics provide health benefits to the host. Probiotics and their metabolites have therapeutic and nutritional properties that help to alleviate gastrointestinal, neurological, and cardiovascular problems. Probiotics strengthen host immunity through various mechanisms, including improved gut barrier function, receptor site blocking, competitive exclusion of pathogens, and the
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A 4-Week Pecan-Enriched Diet Improves Postprandial Lipid Peroxidation in Aging Adults. J. Med. Food (IF 2.4) Pub Date : 2023-08-28 Betsy Cogan,Regis C Pearson,Nathan T Jenkins,Chad M Paton,Jamie A Cooper
Pecans are rich in bioactive compounds known to reduce oxidative stress and provide glucoregulatory benefits. Few studies assessing the effect of a pecan-enriched diet on such health outcomes suggest potential improvements to cardiometabolic health; however, this has not been studied in an older adult population. Thus, we aimed to examine the effect of daily pecan consumption for 4-weeks on fasting
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Extract of Torreya nucifera Pericarps Exhibits a Parasiticidal Effect on the Nematode Parasite, Trichinella spiralis. J. Med. Food (IF 2.4) Pub Date : 2023-08-28 Mi Jin Jeong,Shin Ae Kang,Sun Nyoung Yu,Soon Cheol Ahn,Shin-Ichi Miyoshi,Hye-Sook Kim,Hak Sun Yu
Benzimidazole derivatives can effectively treat nematode parasitic infections; however, some derivatives demand distinct administrative strategies depending on plasma concentration and patient conditions. Numerous studies have examined the potential of natural extracts to exert parasiticidal activity with minimal side effects. Herein, we examined the potential parasiticidal effects of Torreya nucifera
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Review of Patents for Anticancer Agents Targeting Adenosine Monophosphate-Activated Protein Kinase. J. Med. Food (IF 2.4) Pub Date : 2023-08-16 Hyo-Kyoung Choi,Soo-Hyun Park,Jangho Lee,Jin-Taek Hwang
Cancer, caused by abnormal and excessive cellular proliferation, can invade and destroy surrounding tissues and organs through the spreading of cancer cells. A general strategy for developing anticancer agents is to identify biomarkers that, if targeted, can produce a robust cytotoxic effect with minimal side effects. Cell-cycle regulators, checkpoint regulatory genes, and apoptosis-related genes are
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Neuroprotective Effects of Zerumbone on H2O2-Induced Oxidative Injury in Human Neuroblastoma SH-SY5Y Cells. J. Med. Food (IF 2.4) Pub Date : 2023-08-11 Ha-Rin Moon,Jung-Mi Yun
Oxidative stress is recognized as one of the main reasons for cellular damage and neurodegenerative diseases. Zerumbone is one of the sesquiterpenoid compounds in the essential oil of Zingiber zerumbet Smith. Zerumbone exhibits various physiological activities, such as anticancer, antioxidant, and antibacterial effects. However, studies on the neuroprotective efficacy of zerumbone and the mechanism
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Myrtle Berries Seeds Prevent Dyslipidemia, Inflammation, and Excessive Cardiac Reactive Oxygen Species Production in Response to High-Fat Diet-Induced Obesity. J. Med. Food (IF 2.4) Pub Date : 2023-08-10 Mohamed-Amine Jabri,Soumaya Hajaji,Ameni Omrani,Meriam Ben Youssef,Hichem Sebai
Anthocyanins are the major polyphenols in myrtle berries seeds aqueous extract (MBSAE). This study investigates the protective potentials of MBSAE against obesity lipotoxicity and inflammation induced by a high-fat diet (HFD). It also describes the underlying mechanisms involved in its protective effects, with special attention to myocardial reactive oxygen species (ROS) production. Male Wistar rats
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Garcinia mangostana Suppresses Triacylglycerol Synthesis in Hepatocytes and Enterocytes. J. Med. Food (IF 2.4) Pub Date : 2023-08-10 Eun-Bin Kwon,Dong-Oh Moon,Eun Sol Oh,Yu Na Song,Ji-Yoon Park,Hyung Won Ryu,Doo-Young Kim,Young-Won Chin,Hyun-Sun Lee,Su Ui Lee,Mun-Ock Kim
Regulation of diacylglycerol acyltransferase (DGAT) and pancreatic lipase (PL) activities is important in the treatment of triacylglycerol (TG)-related metabolic diseases. Garcinia mangostana, also known as mangosteen, is a traditional medicine ingredient used in the treatment of inflammation in Southeast Asia. In this study, The ethanolic extract of G. mangostana peel inhibited human recombinant DGAT1
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Acalypha australis L. Extract Attenuates DSS-Induced Ulcerative Colitis in Mice by Regulating Inflammatory Factor Release and Blocking NF-κB Activation. J. Med. Food (IF 2.4) Pub Date : 2023-08-02 Bo Chen,Yiqing Wang,YouYa Niu,Shenghua Li
Ulcerative colitis (UC) is a chronic gastroenteric inflammatory disease that may cause life-threatening complications. Currently available therapeutic drugs are not as effective as expected, necessitating the development of new targets and drugs. The etiology and pathogenetic mechanisms of UC are largely unclear; thus, the treatment effects are limited. The aqueous extract of Acalypha australis L.
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Lactobacillus reuteri NCIMB 30242 (LRC) Inhibits Cholesterol Synthesis and Stimulates Cholesterol Excretion in Animal and Cell Models. J. Med. Food (IF 2.4) Pub Date : 2023-08-01 Minhee Lee,Jeongjin Park,Ok-Kyung Kim,Dakyung Kim,Min Ji Han,Seon Hwa Kim,Tae Hoon Kim,Jeongmin Lee
In this study, we evaluated the effects of Lactobacillus reuteri NCIMB (LRC™) supplementation on hypercholesterolemia by researching its effects on cellular cholesterol metabolism in hypercholesterolemic rats (KHGASP-22-170) and HepG2 cell line. Rats were separated into six groups after adaptation and were then fed a normal control (NC), a high-cholesterol diet (HC), or a HC supplemented with simvastatin
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Ethanol-Extracted Acorn Induces Anti-Inflammatory Effects in Human Keratinocyte and Production of Hyaluronic Acid in Human Fibroblasts. J. Med. Food (IF 2.4) Pub Date : 2023-08-01 Jungwhoi Lee,Sung-Eun Jo,Song-I Han,Jae-Hoon Kim
Acorn (Quercus acutissima CARR.) has been used in traditional food and medicinal ethnopharmacology in Asia, and it has shown multifarious functions such as antidementia, antiobesity, and antiasthma functions. However, there is limited scientific evidence about the efficacy of acorn for ameliorating skin problems. Treatment with ethanol-extracted acorns (EeA's) ablated the expression of inducible nitric
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Cardiomodulatory and Antioxidative Potentials of Almond-Citrus Peel Fortified Shortbread in High Fat Diet/L-NAME-Induced Hyperlipidemic-Hypertensive Rats. J. Med. Food (IF 2.4) Pub Date : 2023-08-01 Ayokunle Ademosun,Opeyemi Ojueromi,Olukorede Peace,Ganiyu Oboh
In folk medicine, the almond nut (Terminalia catappa) and orange peel (Citrus sinensis) are cost-effective sources of nutraceutical utilized in the treatment of degenerative diseases. Hyperlipidemia and hypertension are two pathological conditions implicated in cardiovascular disorders. This study sought to evaluate the cardiomodulatory effect of almond-citrus peel fortified shortbread in hyperlipidemic-hypertensive
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Exploration of Gut Microbiome Research in Africa: A Scoping Review. J. Med. Food (IF 2.4) Pub Date : 2023-07-31 Abdulkadir Yusif Maigoro,Mubarak Muhammad,Bashir Bello,Ushotanefe Useh,Soojin Lee
The crucial role of the gut microbiome in various diseases has led to increased interest in interventions and therapeutics targeting the human microbiome. Accordingly, the current scoping review analyzed the diseases and interventions involved in gut microbiome research in Africa. The electronic databases of PubMed, Google Scholar, and Scopus were searched from inception to October 2021. This study
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Anticancer Effects of Washed-Dehydrated Solar Salt Doenjang on Colon Cancer-Induced C57BL/6 Mice. J. Med. Food (IF 2.4) Pub Date : 2023-07-26 So-Young Lee,Geun-Hye Hong,Ji Hyung Chung,Kun-Young Park
This study researched the mineral composition of Korean washed-dehydrated solar salt (WDS) without bittern. It also evaluated the anticancer effects of doenjang (WDSD) prepared using WDS on azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon cancer in C57BL/6 mice. The mineral composition of WDS showed lower Mg (11.71 ± 1.89 g/kg) and S (9.77 ± 2.88 g/kg) contents, and it was confirmed that
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Polyphenol Bioaccessibility and Antioxidant Activity of Pomegranate (Punica granatum) Peel Supplementation in Diet-Induced Obese Rats. J. Med. Food (IF 2.4) Pub Date : 2023-07-26 Anael Mellado-Negrete,Gloria Itzel Peña-Vázquez,Vania Urías-Orona,Ana Laura De La Garza
Fruit by-products are a source of biocompounds with antioxidant properties and potential role in the obesity treatment. This study aimed to assess the effect of pomegranate (Punica granatum) peel (PP) supplementation on the total antioxidant capacity (TAC) in diet-induced obese rats. Thus, an in vitro gastrointestinal digestion was performed to evaluate the total phenolic content (TPC) and the antioxidant
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The Effect of Royal Jelly on Telomere Length and Some Biochemical Parameters in Wistar Albino Rats with Liver Damage Caused by Carbon Tetrachloride. J. Med. Food (IF 2.4) Pub Date : 2023-07-21 Selcen Çakır
Royal jelly (RJ) is a natural bee product that has been used for therapeutic purposes since ancient times. The therapeutic properties of this product, which has rich biological content, are still being investigated with new approaches. In this study, the effect of RJ on telomere length, some antioxidant parameters, and lipid profile was examined. This study will contribute to the literature as it is
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Hovenia dulcis Thunb. Fruit Extract Attenuates Psoriatic Skin Inflammation in Tumor Necrosis Factor-α-Stimulated Human Keratinocyte HaCaT Cells In Vitro. J. Med. Food (IF 2.4) Pub Date : 2023-07-10 Min Young Kim,Mi Ran Kim,Hyung Seo Hwang,Hwa Jin Lee
Hovenia dulcis Thunb. fruit (HDF) is traditionally used for treating liver diseases and alcohol poisoning. The purpose of this study was to explore the effects of HDF on hyperproliferation, levels of inflammatory cytokines, and signaling mechanisms in human psoriatic keratinocyte HaCaT cells. HDF showed a preventive effect on tumor necrosis factor-α (TNF-α)-induced abnormal proliferation of psoriatic
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Effect of Fucoxanthin on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion. J. Med. Food (IF 2.4) Pub Date : 2023-07-04 Armando López-Ramos,Manuel González-Ortiz,Esperanza Martínez-Abundis,Karina G Pérez-Rubio
The aim of this study was to evaluate the effect of fucoxanthin on metabolic syndrome (MetS), insulin sensitivity, and insulin secretion. A randomized, double-blind, placebo-controlled clinical trial was conducted in 28 patients diagnosed with MetS. Patients were randomly assigned to receive 12 mg of fucoxanthin or placebo once a day for 12 weeks. Before and after the intervention, the components of
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Catechin with Lactic Acid Bacteria Starters Enhances the Antiobesity Effect of Kimchi. J. Med. Food (IF 2.4) Pub Date : 2023-07-03 Geun-Hye Hong,So-Young Lee,Jung-Im Yoo,Ji Hyung Chung,Kun-Young Park
The antiobesity effects of kimchi with catechin and lactic acid bacteria as starters were studied in C57BL/6 mice with high-fat diet (HFD)-induced obesity. We prepared four types of kimchi: commercial kimchi, standard kimchi, green tea functional kimchi, and catechin functional kimchi (CFK). Body weight and weight of adipose tissue were significantly lower in the kimchi-treated groups than in the HFD
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Neuroprotective Potential of Brown Seaweed Phytochemicals in Rodent Models of Cerebral Ischemia. J. Med. Food (IF 2.4) Pub Date : 2023-07-03 Khondoker Adeba Ferdous,Sorour Sarihi,Amy C Ellis,Han-A Park
Cerebral ischemia, a condition with insufficient blood flow in the brain, is associated with cognitive and behavioral changes. The underlying cellular mechanisms of ischemia-induced brain damage include oxidative stress and inflammation. Cerebral ischemia is a major cause of death and long-term disability; thus, investigating novel dietary sources and their therapeutic potentials have gained interest
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Inhibitory Effects of Wheat Sprouts Extract on RANKL-Induced Osteoclast Differentiation via Suppressing MAPK and NFATc1 Signaling Pathways. J. Med. Food (IF 2.4) Pub Date : 2023-07-01 Bok Kyung Han,Hyeock Yoon,Kyeong Hoon Kim,Eui-Cheol Shin,Kwang Suk Ko,Hee-Seok Lee,Young Jun Kim
The maintenance of bone is dependent on both osteoclasts, which break down bone, and osteoblasts, which build new bone. Various bone-related disorders, including osteoporosis, can occur as a result of an imbalance between these two cell types. Prolonged use of currently available bone resorption inhibitors may show side effects. Therefore, developing a novel preventive material which effectively inhibits
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Tyrosol: Repercussion of the Lack of a Hydroxyl-Group in the Response of MCF-7 Cells to Hypoxia. J. Med. Food (IF 2.4) Pub Date : 2023-06-28 Jesús Calahorra,Salomé Araujo-Abad,José M Granadino-Roldán,Ángela Naranjo,Esther Martínez-Lara,Eva Siles
In solid tumors, such as breast cancer, hypoxic microenvironment worsens patient prognoses. We have previously reported in MCF-7 breast cancer cells that, under hypoxic conditions, hydroxytyrosol (HT) downregulates the level of reactive oxygen species, reduces the expression of hypoxia inducible factor-1α (HIF-1α), and, at high concentrations, can bind to the aryl hydrocarbon receptor (AhR). With this
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Orange Peel Extract and Physical Exercise Synergistically Ameliorate Type 2 Diabetes Mellitus-Induced Dysmetabolism by Upregulating GLUT4 Concentration in Male Wistar Rats. J. Med. Food (IF 2.4) Pub Date : 2023-06-28 Luqman Aribidesi Olayaki,Kazeem Bidemi Okesina,Jesugbemi Daniel Jesubowale,Ayodeji Johnson Ajibare,Adeyemi Fatai Odetayo
Diabetes mellitus (DM) is a chronic disease and one of the oldest known disorders. It is characterized by dysglycemia, dyslipidemia, insulin resistance (IR), and pancreatic cell dysfunction. Although different drugs, metformin (MET), glipizide, glimepiride, etc., have been introduced to treat type 2 DM (T2DM), these drugs are not without side effects. Scientists are now seeking natural treatments such
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Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function. J. Med. Food (IF 2.4) Pub Date : 2023-06-26 Chien-Ning Huang,Chi-Li Lin,Hsin-Hua Li,Sing-Hua Tsou,Chiung-Huei Peng
Diabetes is highly linked to the occurrence of Alzheimer disease (AD), which is characterized by beta amyloid peptide (Aβ) and hyperphosphorylation of tau (p-tau), and neuron damage particularly in hippocampus. Type 2 diabetes (T2D) is featured by insulin resistance, and phosphorylation of Ser307-IRS-1 is regarded as a resistance marker. Inhibitors of dipeptidyl peptidase-4 (DPP-4) are effective tools
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Yuja Juice and Concentrate Enhance Immunomodulating Effects via Increasing Immune-Related Cytokines in RAW264.7 Cells and Mouse Splenocytes. J. Med. Food (IF 2.4) Pub Date : 2023-06-22 Hyunhee Kim,Minseok Jeong,Min-Jeong Kong,Ji-Eun Jeong,Kyung-Chul Choi
Good immunity is highly valued in modern society. Although yuja's efficacy in immunity enhancement has been elucidated, there have been few studies on its role. In this study, we investigate the immune enhancement activity of yuja juice extracts (YJEs) and yuja concentrate extracts (YCEs). The immunoregulatory potencies of YJE and YCE were examined by determining cell viability and the expression of
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Antiobesity Effect of N-Acetylneuraminic Acid by Enhancing Antioxidative Capacity in Mice Fed a High-Fat Diet. J. Med. Food (IF 2.4) Pub Date : 2023-06-19 Tomoko Kaburagi,Yuko Otsuka,Satoru Oshiro
The sialic acid N-acetylneuraminic acid (NANA), an essential factor in bioregulation, is a functional food component that is known to have beneficial health effects, but its antiobesity effect has not been clearly understood. Adipocyte dysfunction in obesity involves a decrease in the level of NANA sialylation. In this study, we investigated the antiobesity effect of NANA in mice fed a high-fat diet
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Antiobesity Effects of Lactobacillus paracasei Subsp. paracasei, L. casei 431 on High-Fat Diet-Induced Obese Rats. J. Med. Food (IF 2.4) Pub Date : 2023-06-13 Yun Jeong Shin,Jung-Min Bae,Hye-Rin Cho,Patience Mahoro,Hye Hyun Kim,Seon Hwa Kim,Tae Hoon Kim,Min-Jung Bae
Obesity is currently regarded as a global concern, and the key objectives of the global health strategy include its prevention and control. Probiotic supplementation can help achieve these objectives. This study aimed to assess whether a probiotic strain Lactobacillus paracasei ssp. paracasei, Lactobacillus casei 431 (henceforth, L. casei 431) possesses antiobesogenic properties. High-fat diet-induced
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Glycemic Index and Glycemic Load of Two Dishes Cooked with Alache (Anoda cristata) and Chaya (Cnidoscolus aconitifolius) Plants from the Traditional Mexican Diet. J. Med. Food (IF 2.4) Pub Date : 2023-06-01 Josefina Consuelo Morales-Guerrero,Reina Rosas-Romero,Ma Amanda Mariscal-Gálvez,Fabiola Ayala-Alcántara,Héctor Bourges-Rodríguez
Correct nutrition is important for keeping good health; to attain that, the diet has to include vegetables such as quelites. The objective of this study was to determine the glycemic index (GI) and glycemic load (GL) of rice and a tamal prepared with and without two species of quelites: "alache" (Anoda cristata) and "chaya" (Cnidoscolus aconitifolius). The GI was measured in 10 healthy subjects, 7
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Efficacy of Veronica incana for Treating Osteoarthritis Induced by Monosodium Iodoacetate in Rats. J. Med. Food (IF 2.4) Pub Date : 2023-06-01 Jin A Lee,Trung Huy Ngo,Mi-Rae Shin,Jeong Won Choi,Hyukjae Choi,Joo-Won Nam,Seong-Soo Roh
The aim of this study is to investigate the efficacy and the underlying mechanism of Veronica incana in osteoarthritis (OA) induced by intraarticular injection of monosodium iodoacetate (MIA). The selected major four compounds (A-D) of V. incana were found from fractions 3 and 4. Its structure elucidation was determined by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS)
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The Glycemic Index of Indica and Japonica Subspecies Parboiled Rice Grown in Italy and the Effect on Glycemic Index of Different Parboiling Processes. J. Med. Food (IF 2.4) Pub Date : 2023-06-01 Mariangela Rondanelli,Riccardo Anselmo Ferrario,Gaetan Claude Barrile,Davide Guido,Clara Gasparri,Cinzia Ferraris,Alessandro Cavioni,Francesca Mansueto,Giuseppe Mazzola,Zaira Patelli,Gabriella Peroni,Martina Pirola,Claudia Razza,Alice Tartara,Simone Perna
Rice is generally considered a high-glycemic index (GI) food, but numerous studies show that parboiling reduces the GI. There are no studies on GI of Indica and Japonica subspecies parboiled rice grown in Italy. The aim of this study was (1) to evaluate GI in different varieties of parboiled rice (ribe, white and brown long B, basmati, black, red, roma, and arborio); (2) to evaluate GI of same variety
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Cinnamomum cassia on Arterial Stiffness and Endothelial Dysfunction in Type 2 Diabetes Mellitus: Outcomes of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J. Med. Food (IF 2.4) Pub Date : 2023-06-01 Jesús S Delgadillo-Centeno,Fernando Grover-Páez,Sandra O Hernández-González,María G Ramos-Zavala,David Cardona-Müller,Alicia López-Castro,Sara Pascoe-González
Cinnamomum cassia is a medicinal plant whose use has demonstrated benefits on body weight, blood pressure, glucose, and lipids. This study aimed to evaluate the effect of C. cassia on arterial stiffness and endothelial dysfunction (ED) in patients with type 2 diabetes mellitus (T2DM). A randomized, double-blind, placebo-controlled clinical trial was carried out in 18 subjects aged 40-65 years, with
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Physiological Impact of the Non-Nutritive Artificial Sweetener, Aspartame, and the Therapeutic Potential of Aqueous Extract of Phyllanthus niruri. J. Med. Food (IF 2.4) Pub Date : 2023-05-18 Ab Qayoom Naik,Tabassum Zafar,Vinoy K Shrivastava
The present study investigated the impact of aspartame (ASP) on biochemical and histological profiles and the therapeutic potential of aqueous extract of Phyllanthus niruri (PN) in female Swiss albino mice (20 ± 2 g b. w.). ASP (40 mg/kg b. w.) and PN (100 mg/kg b. w.) were fed to the mice for a period of 30 and 60 days. A significant (P ≤ .01) decrease was observed in body weight and relative organ
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Myo-Inositol Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy by Inhibiting PI3K/AKT Activation. J. Med. Food (IF 2.4) Pub Date : 2023-05-16 Xiaofang Hu,Ming Yang,Xiangyi Li,Zhicheng Gong,Jianxiu Duan
Emerging evidence suggests that myo-inositol (MI) has a critical role in reducing renal inflammatory processes and improving podocyte function and preventing diabetes-related renal damage. We aimed to explore the function and underlying workings of MI in renal interstitial fibrosis (RIF). Based on a mouse model, we explored the effect of MI in unilateral ureteral obstruction (UUO) and in transforming
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UP360, a Standardized Composition from Extracts of Aloe barbadense, Poria cocos, and Rosemary officinalis Protected Against Sepsis and Mitigated Acute Lung Injury in Murine Models. J. Med. Food (IF 2.4) Pub Date : 2023-05-16 Mesfin Yimam,Teresa Horm,Alexandria O'Neal,Ping Jiao,Mei Hong,Qi Jia
Sepsis is a life-threatening organ dysfunction caused by a dysregulated and unbalanced immune response to microbial infection. Restoring immune homeostasis and infection control are considered the primary strategies to manage sepsis. Natural bioactives such as polysaccharide and polyphenols from botanicals are known for their immune modulation activity. In this study, we evaluated a standardized aloe-based
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Hepato-Nephroprotective Actions of Salvia officinalis Decoction Extract Against Extraintestinal Alterations Induced with Acetic Acid-Colitis Model in Rats. J. Med. Food (IF 2.4) Pub Date : 2023-05-15 Saber Jedidi,Kais Rtibi,Houcine Selmi,Foued Aloui,Nourhène Dhawefi,Hichem Sebai
Inflammatory bowel disease is associated with multiple extraintestinal disorders, including hepato-nephrological disruptions. The aim of this study was to evaluate the hepato-nephroprotective effect of Salvia officinalis leaf decoction extract (SLDE) on acetic acid (AA)-induced colitis accompanied with liver and kidney injuries. Wistar albinos rats were pretreated with SLDE (50, 100, and 200 mg kg-1
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Natural Products as Modulators of Mitochondrial Dysfunctions Associated with Cardiovascular Diseases: Advances and Opportunities. J. Med. Food (IF 2.4) Pub Date : 2023-05-01 Thaise Boeing,Francislaine Aparecida Dos Reis Lívero,Priscila de Souza,Danielle Ayr Tavares de Almeida,Guilherme Donadel,Emerson Luiz Botelho Lourenço,Arquimedes Gasparotto Junior
The mitochondria have an important role in modulating cell cycle progression, cell survival, and apoptosis. In the adult heart, the cardiac mitochondria have a unique spatial arrangement and occupy nearly one-third the volume of a cardiomyocyte, being highly efficient for converting the products of glucose or fatty acid metabolism into adenosine triphosphate (ATP). In cardiomyocytes, the decline of
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Juniper Berries Regulate Diabetes and Obesity Markers Through Modulating PPARα, PPARγ, and LXR: In Vitro and In Vivo Effects. J. Med. Food (IF 2.4) Pub Date : 2023-05-01 Hee-Sung Chae,Olivia Dale,Tahir M Mir,Mohammad K Ashfaq,Bharathi Avula,Larry A Walker,Ikhlas A Khan,Shabana I Khan
The berries of Juniperus communis have been traditionally used for therapeutic purposes. They have been reported to possess various pharmacological effects such as anti-inflammatory, hypoglycemic and hypolipidemic activities. In this study, a methanolic extract of J. communis berries (JB) was evaluated for its effects on peroxisome proliferator-activated receptors alpha and gamma (PPARα and PPARγ)