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Unlocking the potential of bioanalytical data through machine learning. Anal. Sci. (IF 1.6) Pub Date : 2023-12-01 Shunsuke Tomita
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Determination and speciation of arsenic in drinking water samples by X-ray spectrometry technique. Anal. Sci. (IF 1.6) Pub Date : 2023-11-19 Piyali Deb Barman,Ashok Kumar Maurya,Mukul Madaan,Brijendra Kumar,Ankit Roy,Subhendu Ghosh
Arsenic is ranked as the first compound in the Substance Priority List 2023 by the Agency for Toxic Substances and Disease Registry (ATSDR). The most prominent entrance to the human body is through drinking water wherein the predominant species are arsenite and arsenate. The more toxic As(III) has rigorously threatened human health worldwide; hence, speciation and separation are the need of the hour
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A novel TiO2-modified THPP-BCP composite optical waveguide sensor for the determination of ethylenediamine at ppb level. Anal. Sci. (IF 1.6) Pub Date : 2023-11-17 Buayishamu Kutilike,Kalibinue Yiming,Gulimire Tuerdi,Renagul Abdurahman,Patima Nizamidin,Abliz Yimit
Composite thin films OWG sensors show higher sensitivity than single film-based OWG sensors, making them particularly useful in the detection of trace gases. In this work, we developed a new tetra hydroxyphenyl porphyrin (THPP)-bromocresol purple (BCP)/TiO2 gel composite film-based OWG (THPP-BCP/TiO2-OWG) sensor for identifying ethylenediamine (EDA) gas. The fabricated sensor was characterized using
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On-line sample preconcentration by LVSEP-FASI with simple voltage control on Y-channel chips. Anal. Sci. (IF 1.6) Pub Date : 2023-11-16 Fumihiko Kitagawa,Takahiro Yonekura,Isoshi Nukatsuka
To eliminate complicated voltage controls for highly sensitive microchip electrophoresis (MCE) analyses on the basis of combining two online sample preconcentration techniques, large-volume sample stacking with an electroosmotic flow (EOF) pump (LVSEP) and field-amplified sample injection (FASI), cross-channel microchips and a multichannel high-voltage power supply were replaced to Y-channel chips
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A disposable sensor based on one-pot synthesized tungsten oxide nanostructure-modified screen printed electrodes for selective detection of dopamine and uric acid. Anal. Sci. (IF 1.6) Pub Date : 2023-11-16 Merve Oğuz,Ahmet Aykaç,Mustafa Şen
Here, screen-printed carbon electrodes (SPCEs) were modified with ultrafine and mainly mono-disperse sea urchin-like tungsten oxide (SUWO3) nanostructures synthesized by a simple one-pot hydrothermal method for non-enzymatic detection of dopamine (DA) and uric acid (UA) in synthetic urine. Sea urchin-like nanostructures were clearly observed in scanning electron microscope images and WO3 composition
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Holo/apo conversion two-dimensional urea PAGE for speciation of Fe3+-bound transferrin in serum. Anal. Sci. (IF 1.6) Pub Date : 2023-11-15 Shingo Saito,Junko Ishikawa,Moe Ono,Yuiko Tasaki-Handa,Masami Shibukawa
This paper presents holo/apo conversion two-dimensional urea polyacrylamide gel electrophoresis (HAC-2D urea PAGE) as a novel method for speciating Fe3+-bound transferrin (Tf) species in biological samples, with a combination of metal ion contaminant sweeping (MICS) technique and Fe3+ detection PAGE. In the HAC-2D urea MICS-PAGE approach, HAC was performed to dissociate all the Fe3+ ions bound to Tf
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Gum Arabic-mediated synthesis of silver nanoparticles for their applications as colorimetric and SERS-based detection of hydrogen peroxide. Anal. Sci. (IF 1.6) Pub Date : 2023-11-09 Shukla Majhi,Ashish Kumar,Surbhi Sharma,Chandra Shekhar Pati Tripathi,Debanjan Guin
We report on the one-step green method to synthesize Gum Arabic stabilized silver nanoparticles (GA-Ag NPs). The synthesized particles are monodispersed and in the size range of 15-20 nm. The synthesized Ag NPs are used as a colorimetric sensor for the detection of H2O2 and glucose with a detection limit of 11.7 nM and 0.13 µM, respectively. The sensor has also been used for the detection of H2O2 in
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Evaluation of solvent property of air-water interface based on the fluorescence spectra of 1,2'-dinaphthylamine in the aqueous solution of ultrafine bubbles. Anal. Sci. (IF 1.6) Pub Date : 2023-11-08 Koki Kodama,Shogo Hattori,Keiji Yasuda,Tohru Saitoh
Solvent property of air-water interface was evaluated based on the fluorescence spectra of 1,2'-dinaphthylamine in water containing ultrafine bubbles (average diameter: 103 nm, standard deviation: 38 nm). Among naphthylamine derivatives whose fluorescence spectra were responsive to microscopic hydrophobicity, 1,2'-dinaphthylamine (DN) was selected because its wavelength of the maximum emission (λmax)
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Preliminary studies of XANES and DFT calculation of Ru extraction by imino-diacetamide and related compounds. Anal. Sci. (IF 1.6) Pub Date : 2023-11-07 Yuji Sasaki,Masahiko Nakase,Masashi Kaneko,Tohru Kobayashi,Kenji Takeshita,Masahiko Matsumiya
We connected three research fields on Ru extraction, XANES, and DFT calculation and elucidate the sequence of distribution ratio (D) and their reactions. The magnitude order of the distribution ratio, D(Ru), from acids, HCl > H2SO4 > HNO3 > HClO4, by IDOA indicates to extract readily the stable Ru-Cl ions. The XANES signals, which suggests the electrical charge of Ru(III) extracted into the organic
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Development and validation of Empagliflozin and Linagliptin simultaneous estimation in rat plasma using freezing lipid precipitation and SCX-SPE assisted HPLC-MS/MS method and its application in pharmacokinetic studies. Anal. Sci. (IF 1.6) Pub Date : 2023-11-03 Anil Kumar Goud Thallapalli,Ram Mohan Manda
A quick and sensitive liquid chromatography-mass spectrometry technique was designed, improved, and validated for simultaneous determination of Empagliflozin (EPG) and Linagliptin (LNG) using Empagliflozin-d4 (EPG-d4) and linagliptin-d4 (LNG-d4) as internal standards (IS) in rat plasma. Target analytes and the IS were extracted using freezing lipid precipitation (FLP) and optimized using the strong
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Recent topics in X-ray fluorescence spectrometry. Anal. Sci. (IF 1.6) Pub Date : 2023-11-01 Kazuhiko Nakano
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Improvement of humic acid (HA) removal using a new inorganic-organic composite coagulant: α-costic acid as a modifier of polyaluminum chloride properties. Anal. Sci. (IF 1.6) Pub Date : 2023-10-30 Fatima Ezzahra Maaghloud,Anouar Abdellah Elfoulani,Achraf Abdou,Mohamed Chafi,Ahmed El Hakmaoui,Abdelhakim Elmakssoudi,Jamal Jamal Eddine,Mohamed Akssira,Mohamed Dakir
In this work, α-costic acid (αCA), a plant sesquiterpenoid from Dittrichia viscosa, was grafted into polyaluminum chloride (PAC), forming a new eco-sustainable composite coagulant PAC-αCA with improved functionality. The α-costic acid fraction grafted into the PAC and the distribution of aluminum forms in the composite coagulant were evaluated for their effectiveness in removing bentonite and humic
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Computational quality-by-design strategy to validate high-performance liquid chromatography method for the estimation of meloxicam in bulk dosage forms and milk samples. Anal. Sci. (IF 1.6) Pub Date : 2023-10-26 Vaskuri G S Sainaga Jyothi,Harithasree Veerabomma,Chantibabu Katta,Jitender Madan
Bovine clinical mastitis has significant repercussions for farmers across the globe. Meloxicam, a COX-2 inhibitor, attenuates mastitis symptoms and is also approved for veterinary use. An RP-HPLC (Reverse Phase-High Performance Liquid Chromatography) method development and validation is essential in the pharmaceutical industry to assess API (Active Pharmaceutical Ingredient) quantity present in the
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Volatile anticancer drug determination by thermal desorption technique with polydimethylsiloxane-coated macroporous silica adsorbent in gas chromatography-mass spectrometry. Anal. Sci. (IF 1.6) Pub Date : 2023-10-25 Ikuo Ueta,Katsunori Sumiya,Koji Fujimura,Yuki Ariizumi,Ryosuke Kikuchi,Keishi Kawata,Yoshihiro Saito
An analytical method for quantifying the volatile anticancer drugs ifosfamide (IF) and cyclophosphamide (CP) in air was developed on the basis of thermal desorption (TD)-gas chromatography-mass spectrometry. Polydimethylsiloxane-coated macroporous silica was used as the adsorbent. The extraction tube was prepared by packing 0.2 g of adsorbent particles into a glass tube. The extraction and desorption
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Chemical characterization of the crude extract of Sauromatum venosum (voodoo lily) and docking study with 12-O-acetylingol 8-tiglate for cytotoxicity testing in SaOS2 (osteoblastic osteosarcoma cells). Anal. Sci. (IF 1.6) Pub Date : 2023-10-23 Namrata Kahar,Preeti Mishra,Renu Bhatt,Rohit Seth
The current study was carried out to investigate the anticancer potential of Sauromatum venosum (SV) tuber by gas chromatography with high-resolution mass spectrometry (GC-HRMS) analysis of ethanolic (eSV), hydroalcoholic (hSV), and aqueous extracts (wSV), and in silico study were performed to investigate the main targets of 12-O-acetylingol 8-tiglate by computational docking. The GC-HRMS analysis
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Aptamer-functionalized polydiacetylene biosensor for the detection of three foodborne pathogens. Anal. Sci. (IF 1.6) Pub Date : 2023-10-19 Yuhong Zhong,Jiaqi Wu,Xiaoyan Pan,Bo Liu,Lin Wang
Rapid, simple and sensitive screening of foodborne pathogens is of great significance to ensure food safety. In this study, an aptamer-functionalized polydiacetylene (Apta-PDA) biosensor was developed for the detection of E. coli O157:H7, S. typhimurium or V. parahaemolyticus. First, aptamers responding to the target bacteria were modified on the surface of magnetic beads by covalent binding to form
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Heterogeneous photocatalytic degradation of antiviral drug didanosine mediated by rose bengal and TiO2 nanoparticles. Anal. Sci. (IF 1.6) Pub Date : 2023-10-17 Waseem Ahmad,Sanjay Kumar,Monu Verma
There is a great concern among the researcher to remove the problem of the persistent organic pollutants in wastewater. Pharmaceutical agrochemical and personal care products are generally considered Persistent organic pollutants. Therefore, it is a matter of concern to develop new techniques how to remove these pollutants safely at low cost. This study mainly focuses on the commonly used antiviral
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A disposable voltammetric sensor for the determination of diphenylamine using modified pencil graphite electrode. Anal. Sci. (IF 1.6) Pub Date : 2023-10-16 Santhy Antherjanam,Beena Saraswathyamma
This study reports the electrochemical monitoring and sensing of diphenylamine (DPA), an anti-scald agent on a modified pencil graphite electrode (PGE). DPA is also a potentially toxic environmental pollutant. A polymer of tyrosine synthesized by electrochemical process was utilized for the determination of DPA in real samples. The electrodes were characterized using IR, SEM, EDAX, AFM and EIS analyses
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Highly efficient determination of metal ion in cosmetic samples by reversed-phase liquid-liquid microextraction based on green hydrophobic deep eutectic solvent. Anal. Sci. (IF 1.6) Pub Date : 2023-10-16 Bangfu Liu,Le-Zhou Zhou,Guo-Wen He,Chaoli Wang
In this paper, a green hydrophobic deep eutectic solvent (HDES) composed of menthol and hexanoic acid was employed to dissolve cosmetics containing Cd2+ and Cd2+ was extracted using an EDTA-2Na saturated solution, analyzed by FAAS. The study found that HDES-1 can be recycled and reused well; the stability constants of Cd2+ EDTA chelates play an important role in the extracting process; the optimum
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A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation. Anal. Sci. (IF 1.6) Pub Date : 2023-10-16 Liang Lai,Mengyun Zhang,Chusheng Liu,Jiahuan Qu,Dongsheng Xu,Zhengjin Jiang
Rapid and effective separation of nucleotides (NTs) and their derivatives is crucial for studying their physiological functions. In this work, we comprehensively evaluated the separation ability of a zwitterionic hydrophilic monolith, i.e., poly(N,N-dimethyl-N-(3-methacrylamidopropyl)-N-(3-sulfopropyl)ammonium betaine-co-N,N'-methylenebisacrylamide) (poly(SPP-co-MBA)) for NTs analysis, including its
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Compositional analysis of copper and iron-based alloys using LIBS coupled with chemometric method. Anal. Sci. (IF 1.6) Pub Date : 2023-10-16 Vikas Gupta,Abhishekh Kumar Rai,Tejmani Kumar,Akash Tarai,G Manoj Kumar Gundawar,A K Rai
The present manuscript deals with the utility of the calibration-free LIBS and calibration curve methods for the compositional study of different alloys using laser-induced breakdown spectroscopy (LIBS). In the process of alloying in the smelting industry, metal concentration in different alloys affects the physical and chemical properties of the final products. Therefore, LIBS can be used as an efficient
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Real-time three-dimensional micro-imaging of liquid front in spreading sessile droplet under transient spreading states. Anal. Sci. (IF 1.6) Pub Date : 2023-10-15 Shu-Hei Urashima,Makoto Tanitsu,Masanobu Kawamoto,Hiroharu Yui
Dynamic wetting behaviors of sessile droplets on substrates play crucial roles for various industrial chemical processes. In the case of complete wetting, it has been proposed that a precursor film which is nanometer-order thickness and micrometer-order length further expands outside the macroscopic contact line of the sessile droplet. While the time evolution of the precursor film is believed to strikingly
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NMR screening method based on 19F spin-spin relaxation time for analyses of fluorinated compound bound to proteins. Anal. Sci. (IF 1.6) Pub Date : 2023-10-15 Kazuo Furihata,Mitsuru Tashiro
NMR screening methods based on 19F spin-spin relaxation time (19F-T2) were applied to fluorinated compounds bound to human serum albumin. Diflunisal and fleroxacin (the fluorinated compounds) contain two and three fluorine atoms per molecule, respectively, and are suitable as the model system for 19F NMR analysis. It was shown that 19F-T2 was more sensitive in monitoring the binding affinity to the
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Phase-separation multiphase flow: preliminary application to analytical chemistry. Anal. Sci. (IF 1.6) Pub Date : 2023-10-14 Kazuhiko Tsukagoshi
A two-phase separation mixed solution can undergo phase separation from one phase to two phases (i.e., upper and lower phases) in a batch vessel in response to changes in temperature and/or pressure. This phase separation is reversible. When the mixed solution undergoes a phase change while being fed into a microspace region, a dynamic liquid-liquid interface is formed, leading to a multiphase structure
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Characterization of balsam sulfide via pyrolysis-gas chromatography-mass spectrometry/sulfur chemiluminescence detection and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal. Sci. (IF 1.6) Pub Date : 2023-10-13 Yoshihide Maeno,Hajime Ohtani,Shinya Kitagawa,Yoshinori Iiguni,Takamasa Yoshimi,Taisuke Nakamura,Toshinori Yamaguchi
Balsam sulfide, produced by the reaction of turpentine/rosin and sulfur, has been used as one of the raw materials of liquid gold to decorate ceramics and tableware with thin gold film for more than 100 years. The characterization of balsam sulfide is still insufficient because of its compositional complexity. In this study, balsam sulfide was characterized using pyrolysis-gas chromatography (Py-GC)-mass
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Identification of novel metabolites of abiraterone in human serum and their metabolic pathways. Anal. Sci. (IF 1.6) Pub Date : 2023-10-13 Shizuyo Horiyama,Noboru Hayama,Hiroki Yoneyama,Yoshihide Usami,Jun Haginaka
Two novel abiraterone (Abi, 3β-OH-Abi) metabolites in human serum were identified as 3α-OH-Abi and Δ5-Abi (D5A). Both metabolites were confirmed by their retention times on LC/MS and their product-ion mass spectra on LC-MS/MS compared to those of authentic compounds, which were chemically synthesized. The plausible metabolic pathways of these two metabolites are as follows: Abi is first oxidized to
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Preparation of gold nanoparticles using low-temperature heating of the dry residue of a droplet of an HAuCl4 solution in air. Anal. Sci. (IF 1.6) Pub Date : 2023-10-13 Kazuki Ii,Yoshiki Kurita,Naoya Kida,Shinsuke Kunimura
In the present study, by heating a quartz glass substrate having the dry residue of a 10 μL droplet of a solution of HAuCl4 and a counter substrate facing to the dry residue from room temperature to one hundred and several tens of degrees Celsius in 20 min in air, highly dense gold nanoparticles were produced on the counter substrate. A gold nanoparticle substrate produced by this simple method was
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Investigating hydrophobic environment in alkyl-group-functionalized silica particle with various chain lengths using absorption microspectroscopy. Anal. Sci. (IF 1.6) Pub Date : 2023-10-09 Akihisa Miyagawa,Kazuki Yamada,Kiyoharu Nakatani
A well-known solvatochromic dye, Reichardt's dye (R-dye), was used to evaluate the hydrophobicity of alkyl-group-functionalized silica particles (ASPs) with different chain lengths. The absorption spectra of R-dye were measured in a single ASP in a mixed solution of water and an organic solvent (methanol (MeOH), ethanol (EtOH), acetonitrile (ACN), tetrahydrofuran (THF), or N,N-dimethylformamide (DMF))
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Separation of an ε-poly-L-lysine derivative by solvent extraction under a controlled interfacial potential difference. Anal. Sci. (IF 1.6) Pub Date : 2023-10-09 Hajime Katano,Mami Maruyama,Kohei Uematsu,Chitose Maruyama,Yoshimitsu Hamano
This paper describes the availability of a 1,2-dichloroethane (DCE)-water (W) interfacial system under a controlled interfacial potential difference for the separation of polycationic species. The system was applied to the production of polyethylene glycol-modified ε-poly-L-lysine (PEG-εPL). PEG-εPL is produced by a fermentation process, and the crude product contains a significant amount of non-modified
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Digital PCR using a simple PDMS microfluidic chip and standard laboratory equipment. Anal. Sci. (IF 1.6) Pub Date : 2023-09-14 Kazuo Hosokawa,Hitoshi Ohmori
Digital PCR (dPCR) enables sensitive and precise quantification of template nucleic acid without calibration. However, dPCR is not yet in widespread use, probably due to the need for expensive specialized instruments. In this paper, we describe a dPCR system using a simple microfluidic chip and common laboratory tools. The microfluidic chip consists of two parts: a PDMS part with 24,840 × 0.25 nL microwells
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Pentafluorobenzylpyridinium: new thermometer ion for characterizing the ions produced by collisional activation during tandem mass spectrometry. Anal. Sci. (IF 1.6) Pub Date : 2023-09-14 Daiki Asakawa,Kazumi Saikusa
In this study, pentafluorobenzylpyridinium (F5-BnPy+), which has the highest dissociation energy among the reported benzylpyridinium thermometer ion, is proposed to characterize the internal energy distributions of ions activated by higher energy collisional dissociation (HCD) and ion-trap collision-induced dissociation (CID) during tandem mass spectrometry. The dissociation threshold energies of F5-BnPy+
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Nanobody based immunoassay for alpha fetal protein detection using streptavidin-conjugated polymerized horseradish peroxidase for signal amplification. Anal. Sci. (IF 1.6) Pub Date : 2023-09-13 Danyang Sun,Xing Liu,Kunlu Bao,Long Wu,Huijuan Kuang,Hua Pei,Qi Chen
The enzyme-linked immunosorbent assay (ELISA) offers several advantages, including simple operation, high throughput, and low cost, making it an ideal immunoassay method for efficient screening of disease-related biomarkers in clinical samples. However, the traditional colorimetric ELISA has relatively low sensitivity, which promotes the continuous emergence of various novel signal amplification technologies
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Total electron yield (TEY) efficiency of sp2 and sp3 carbon atoms in the TEY-X-ray absorption near-edge structure (XANES) of 1,4,7,10-alkyltetracenes. Anal. Sci. (IF 1.6) Pub Date : 2023-09-13 Yasuji Muramatsu,Tsuyoshi Ooe,Yuma Hirai
X-ray absorption near-edge structure (XANES) in the CK region of 1,4,7,10-alkyltetracenes, which are composed of sp2-C atoms in the tetracene ring and sp3-C atoms in the alkyl-chains, are measured using the total electron yield (TEY) and theoretically analyzed by DFT calculations to quantitatively investigate the π* and σ* peak intensities in the TEY-CK-XANES. The calculated π*/σ* peak intensity ratios
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Diverse applications and development of aptamer detection technology. Anal. Sci. (IF 1.6) Pub Date : 2023-09-13 Haozheng Li,Shibo Yao,Cui Wang,Chenjun Bai,Pingkun Zhou
Aptamers have received extensive attention in recent years because of their advantages of high specificity, high sensitivity and low immunogenicity. Aptamers can perform almost all functions of antibodies through the combination of spatial structure and target, which are called "chemical antibodies". At present, aptamers have been widely used in cell imaging, new drug development, disease treatment
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Nanozyme colorimetric sensing of L-cysteine and copper ions based on PtCo nanoparticles@multi-walled carbon nanotubes. Anal. Sci. (IF 1.6) Pub Date : 2023-09-12 Xiaorong Lin,Changting Wang,Liuxia You,Fanrui Fu,Qiaoling Liu
In this work, PtCo bimetallic nanoparticles supported on multi-walled carbon nanotubes (PtCo@MWCNTs) nanohybrid was prepared simply and used for the first time as a novel nanozyme in the colorimetric sensing of L-cysteine (L-Cys) and Cu2+. Due to its strong enzyme-like catalytic activity, the prepared PtCo@MWCNTs nanohybrid can catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to form
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The evaluation of photochemical behavior of antihistaminic drug triprolidine in an aqueous media. Anal. Sci. (IF 1.6) Pub Date : 2023-09-07 Kohei Kawabata,Misaki Masumoto,Masanori Inagaki,Hiroyuki Nishi
Photodegradation is widely known as a changer of both the quality and the quantity of several chemical compounds. In this study, we sought to examine the photochemical behavior of triprolidine (TRP), which is a member of the first-generation antihistamine and utilized for a relief of an allergic conditions, in an aqueous media. There are no reports focused on its potential photoproducts and photodegradation
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Mixed-mode chromatographic performance using nicotinic acid-functionalized chito-oligosaccharide-bonded Ti/Si hybrid monolithic capillary columns. Anal. Sci. (IF 1.6) Pub Date : 2023-09-06 Mahmoud A M El-Nouby,Lee Wah Lim
This article describes the fabrication of porous nicotinic acid-functionalized chito-oligosaccharide-bonded titania/silica hybrid monoliths (TiO2/SiO2@ChO-N) through a co-gelation sol-gel process. A capillary monolith with a well-defined and homogeneous structure was obtained by controlling the hydrolysis speed of titanium alkoxides in a sol mixture by using glycerol and acetylacetone. As a result
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Electrochemical determination of ethylvanillin based on LaV@GAC nanocomposite. Anal. Sci. (IF 1.6) Pub Date : 2023-09-05 Haijun Du,Yu Duan,Jixing Ai,Dabin Kong,Dexiang Wang,Huali Hu,Hong Wang,Yang Yang
Ethyl vanillin (EVA) is widely used as a flavor additive in foods, and sensitive monitoring of EVA is of great significance for food safety. In this paper, the biomass of gum arabic derived carbon (GAC) coated with lanthanum vanadate (LaV) was constructed for the EVA sensor based on the synergistic effects of the electrochemical catalytic ability of LaV, the enhanced electrical conductivity with the
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Analysis of polyisoprene oligomers via in situ silver nanoparticle formation on thin-layer chromatography plate using matrix-assisted laser-induced desorption/ionization mass spectrometry. Anal. Sci. (IF 1.6) Pub Date : 2023-09-05 Ryota Irifune,Takanao Ishikawa,Shinya Kitagawa,Yoshinori Iiguni,Hajime Ohtani
The direct mass spectrometry (MS) detection of polyisoprene (PI) oligomers on a thin-layer chromatography (TLC) plate using matrix-assisted laser-induced desorption/ionization (MALDI) with silver trifluoroacetate as the cationization reagent was investigated. The spots of PI oligomers and silver trifluoroacetate on the TLC plate resulted in brown materials after UV laser irradiation. It was suggested
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Geographical origin traceability of mulberry leaves using stable hydrogen, oxygen, and carbon isotope ratios. Anal. Sci. (IF 1.6) Pub Date : 2023-09-04 Dan Yang,Liling Jia,Yang Zhou,Jingzhong Lu,Yujie He,Jinpeng Jiao,Ju Huang,Runtao Xia,Yuxing Li,Lihua Han,Zhiqin Peng
Geographical discrimination of mulberry leaves is very important for their efficacy and quality as a traditional Chinese medicine. Stable hydrogen, oxygen, and carbon isotope ratios were measured in 292 mulberry leaves collected at 2 growth stages in 2 seasons from 8 regions of China. A stepwise linear discriminant analysis (LDA) approach were proposed to combine with stable isotope technology to tracing
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Development of a liquid chromatography-based versatile bioanalysis for bevacizumab based on pretreatment combining aptamer affinity purification and centrifugal ultrafiltration concentration. Anal. Sci. (IF 1.6) Pub Date : 2023-09-03 Kenichiro Todoroki,Daichi Hamada,Tomohiro Yamada,Taro Saito,Yutaka Shimizu,Eiji Sugiyama,Hajime Mizuno,Hideki Hayashi,Kaori Tsukakoshi,Kazunori Ikebukuro
We report on the development of a versatile and accurate bioanalytical method for bevacizumab using a pretreatment method combining affinity purification with anti-idiotypic DNA aptamers and centrifugal ultrafiltration concentration, followed by liquid chromatography (LC)-fluorescence analysis. An affinity purification method using Sepharose beads as an affinity support removed immunoglobulin G and
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Rapid determination of domoic acid in seafood by fluorescence polarization immunoassay using a portable analyzer. Anal. Sci. (IF 1.6) Pub Date : 2023-08-31 Yu Ogura,Mao Fukuyama,Motohiro Kasuya,Koji Shigemura,Sergei A Eremin,Manabu Tokeshi,Akihide Hibara
Monitoring phycotoxin accumulation in marine products such as edible shellfish is a regulatory requirement in many countries. Therefore, a simple and rapid onsite quantification method is sought. Herein, we present a fluorescence polarization immunoassay (FPIA), a well-known one-step immunoassay, using a portable fluorescence polarization analyzer for domoic acid (DA), widely referred to as the primary
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Sensitive detection of heavy metal stress in aquatic plants by dissolved oxygen-quenched fluorescence/materials movement-induced beam deflection method. Anal. Sci. (IF 1.6) Pub Date : 2023-08-31 Xing-Zheng Wu,Kansuk Patthamawan,Yosuke Okuhata
Sensitive detection of heavy metal (HM) stress in aquatic plants by dissolved oxygen (DO)-quenched fluorescence/materials movement-induced beam deflection method is demonstrated. Egeria densa Planchon and Cu2+ were used as a model aquatic plant and HM ion, respectively. Reproducibility and experimental errors of the method were first investigated in a control culture solution only containing 10-6 M
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A highly selective sensor based on p-tetranitrocalix[4]arene-capped copper nanoparticles for colorimetric and bare-eye detection of cyclophosphamide. Anal. Sci. (IF 1.6) Pub Date : 2023-08-29 Ali Hyder,Safia Sanam Memon,Jamil Ahmed Buledi,Shahabuddin Memon,Zafar-Ul-Abdin Memon,Dhani Bux Rajpar,Sirajuddin
In the current study, one of the outstanding facile and simple protocols is proposed for the synthesis of copper nanoparticles (CuNPs) using NaBH4 as a reducing agent and p-tetranitrocalix[4]arene (p-TNC4) as a capping agent. According to our knowledge, no such technique is available in the literature for colorimetric detection of cyclophosphamide (CPA) using CuNPs at the trace level. The well-organized
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Determination of o-phthalaldehyde for dose verification of the clinical disinfectant by fluorescent sequential injection analysis. Anal. Sci. (IF 1.6) Pub Date : 2023-08-26 Hung-Yu Chen,Richie L C Chen,Bo-Chuan Hsieh,Tzong-Jih Cheng
A new automated, generic analytical approach for determining the clinical disinfectant o-phthalaldehyde (OPA) is reported in this study. The proposed sequential injection analysis (SIA) is based on the online reaction of the OPA with glycine/N-acetylcysteine (NAC) in a neutral medium (pH = 7.0) to form a highly fluorescent isoindole derivative. All critical flow and reaction variables were investigated
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Copper corrosion prevention in 3.5% NaCl solution by Spartium junceum petals extract as an eco-friendly bio-inhibitor: kinetic and thermodynamic studies. Anal. Sci. (IF 1.6) Pub Date : 2023-08-19 Mojtaba Askari,Ali Ghaffarinejad
During the last decades, numerous studies were performed to introduce green corrosion inhibitors. So, various materials were utilized due to their being bio-degradable, available, and inexpensive. Because of the aforementioned aspects, Spartium Junceum petals extract (SJPE) was used as a new bio-inhibitor for the prevention of copper corrosion in a 3.5 wt% NaCl solution. This extract was obtained in
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Arctangent normalization and principal-component analyses merge method to classify characteristics utilizing time-dependent material data. Anal. Sci. (IF 1.6) Pub Date : 2023-08-18 Makoto Furukawa,Yasuhiro Niida,Kyoko Kobayashi,Makiko Furuishi,Rika Umezawa,Osamu Shikino,Toshiyuki Suzuki
We propose a technique for classifying paints with time-dependent properties using a new method of merging principal-component analyses (the "PCA-merge" method) that utilizes shifting of the barycenter of the PCA score plot. To understand the molecular structure, elemental concentrations, and the concentrations in the evolved gaseous component of various paints, we performed comprehensive characterizations
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In-situ formation of the adsorbent based on octadecylamine for the extraction of Ag+ ions from aqueous solutions and its determination by microinjection flame atomic absorption spectrometry. Anal. Sci. (IF 1.6) Pub Date : 2023-08-18 Ali Asghar Zendehdel,Saeed Mohammad Sorouraddin,Mir Ali Farajzadeh
In this research, a dispersive solid phase extraction procedure based on changing the solubility of octadecylamine with pH was proposed to determine Ag+ ions in different water samples. For this purpose, first, the pH of sample solution containing the analyte was adjusted to 10.5. Then desired volume of the octadecylamine dissolved in acidic solution was injected into the solution. Because of the low
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Development of a tetra-primer ARMS-PCR for identification of sika and red deer and their hybrids. Anal. Sci. (IF 1.6) Pub Date : 2023-08-17 Yu Ke-Xin,Chen Xiang,Hu Qing-Qing,Yao Yi-An,Wang Xiao-Ming,Xu Ai-Chun,Ge Jian,Guan Feng
Accurate identification of deer-derived components is significant in food and drug authenticity. Over the years, several methods have been developed to authenticate these products; however, identifying whether female deer products are hybrids is challenging. In this study, the zinc finger protein X-linked (ZFX) gene sequences of sika deer (Cervus nippon), red deer (Cervus elaphus) and their hybrid
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Synthesis of azo-linked covalent organic polymers for pipette tip solid-phase extraction of sedative residues from animal tissues samples. Anal. Sci. (IF 1.6) Pub Date : 2023-08-16 Jian Jun Xiang,Li Juan Yuan,Qie Gen Liao,Da Wen Zhang,Lin Guang Luo
Azo-linked covalent organic polymers (ACOPs) were synthesized by a simple azo reaction, with 2,2'-bis(trifluoromethyl)benzidine and 1,3,5-trihydroxybenzene as the monomers. The preparation process was mild, green, and environmental-friendly, avoiding the use of high temperature, metal catalysis, and harmful organic reagent. The obtained ACOPs were characterized by scanning electron microscopy, Fourier
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Development and validation of UV spectrophotometric method for estimation of naringenin in phytosomal formulation: interlaboratory comparison, capability, and statistical analysis. Anal. Sci. (IF 1.6) Pub Date : 2023-08-12 Vijay Metkari,Rohit Shah,Nitin Salunkhe
The goal of the current work was to establish a simple, reproducible, and reliable UV spectrophotometric method for determining naringenin in phytosomal formulations. The solvent methanol was optimized and spectrophotometric analysis was carried out at 289 nm. The proposed method was also validated for linearity, specificity, accuracy, precision, ruggedness, and robustness in accordance with the International
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A colorimetric aptasensor for detecting ochratoxin A based on label-free aptamer and gold nanozyme. Anal. Sci. (IF 1.6) Pub Date : 2023-08-11 Jidong Tang,Bing Tian,Xiaoqi Tao
In this study, the aptamer of ochratoxin A (OTA) increased the negative charge density on the surface of gold nanoparticles (AuNPs) and promoted the release of hydroxyl radicals and Au3+ to enhance the peroxidase-like activity of the AuNPs. The OTA bound only to the aptamer and did not adsorb non-specifically to the AuNPs. Based on these two conclusions, a label-free colorimetric aptasensor was successfully
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Eu(III) transfer in single N,N,N',N'-tetraoctyldiglycolamide-impregnated polymer-coated silica particle using fluorescence microspectroscopy: transfer mechanism and effect of polymer crosslinking degree. Anal. Sci. (IF 1.6) Pub Date : 2023-08-09 Akihisa Miyagawa,Takumi Takahashi,Yoshiaki Kuzure,Hibiki Iwamoto,Tsuyoshi Arai,Shigenori Nagatomo,Sou Watanabe,Yuichi Sano,Kiyoharu Nakatani
A microcapillary manipulation system combined with fluorescence microspectroscopy enabled us to analyze mass transfer in a single particle. In this study, we revealed the Eu(III) distribution in a single diglycolamide-derivative extractant (TODGA)-impregnated polymer-coated silica particle. The reaction of Eu(III) with two TODGA molecules in the polymer layer was the rate-limiting process, which was
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Trigger-activated autonomous DNA machine for amplified liver cancer biomarker microRNA21 imaging. Anal. Sci. (IF 1.6) Pub Date : 2023-08-08 Jiqin Su,Maolin Wang,Peiyi Lin,Zhishu Huang,Guibin Li,Xiangru Chen,Huidi Yan,Lixin Zhou
MicroRNA-21 (miRNA-21) is a kind of RNA that exists in biological fluids such as blood, urine and saliva. It has over expression in liver cancer and has different expression in different stages of cancer. However, due to the characteristics of small base number, short length, low abundance and easy degradation of miRNA-21, the detection of miRNA-21 is a challenging subject. Visualization, sensitive
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A colorimetric fluorescent probe for the detection of carboxylesterase and carbamate pesticides. Anal. Sci. (IF 1.6) Pub Date : 2023-08-07 Jingyi Feng,Yue Gong,Shaoxiang Yang,Hongyu Tian,Baoguo Sun
A colorimetric fluorescent probe (BTCNA) was developed for the determination of carboxylesterase and carbamate pesticides. The probe used naphthalene-benzothiazole as the fluorescent group and naphthyl acetate as the recognition group. The recognition mechanism of BTCNA for carboxylesterase was based on the enzymatic hydrolysis of naphthyl acetate by carboxylesterase (CES). The test paper of the BTCNA
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Photodegradation profiling of nitrendipine: evaluation of active pharmaceutical ingredient, tablets and its altered forms. Anal. Sci. (IF 1.6) Pub Date : 2023-08-04 Kohei Kawabata,Haruka Muraoka,Masatsugu Miyara,Yaichiro Kotake,Hiroyuki Nishi
Nitrendipine (NTR) is a dihydropyridine drug, which is well-known as a photodegradable pharmaceutical. However, the photochemical reaction of NTR has not been evaluated in detail from now. In this study, we perform the photodegradation profiling of NTR for the elucidation of its photochemical behavior. NTR amounts during ultraviolet light (UV) irradiation were monitored using high performance liquid
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Flourescence sensors for heavy metal detection: major contaminants in soil and water bodies. Anal. Sci. (IF 1.6) Pub Date : 2023-08-02 M Singh,J Kumar
Due to the increasing consumption of heavy metals, there is a rising need for specific and useful methods that are employed for the detection of heavy metals. Fluorescence sensing is a highly selective, rapid and biosensing technique that is employed in the determination of some heavy metals in any sample of soil or water, any other living person, the food being consumed or any other substance which
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Quantitative analysis of powder samples using screen-printing techniques as sample preparation methods for LA-ICP-MS. Anal. Sci. (IF 1.6) Pub Date : 2023-08-01 Masahiro Kobayashi,Hiromasa Namiki,Hideo Hayashi
The combination of laser ablation and inductively coupled plasma mass spectrometry (LA-ICP-MS) offers a powerful tool for directly analyzing solid samples. However, LA-ICP-MS has a limitation in quantitative analyses owing to a requirement for matrix-matched standard materials. In this study, we have developed a sample preparation method that facilitates quantitative analyses by LA-ICP-MS. The sample
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Techniques for high spatial resolution in mass spectrometry. Anal. Sci. (IF 1.6) Pub Date : 2023-08-01 Eiji Sugiyama
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Development of practical techniques for simultaneous detection and distinction of current and emerging SARS-CoV-2 variants. Anal. Sci. (IF 1.6) Pub Date : 2023-07-30 Tuocen Fan,Chengjie Li,Xinlei Liu,Hongda Xu,Wenhao Li,Minghao Wang,Xifan Mei,Dan Li
Countless individuals have fallen victim to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and have generated antibodies, reducing the risk of secondary infection in the short term. However, with the emergence of mutated strains, the probability of subsequent infections remains high. Consequently, the demand for simple and accessible methods for distinguishing between different variants