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Correction to: Preparation and characterization of different geometrical shapes of multi-bore hollow fiber membranes and application in vacuum membrane distillation J Anal Sci Technol (IF 1.66) Pub Date : 2021-01-12 Elham M. El-Zanati; Eman Farg; Esraa Taha; Ayman El-Gendi; Heba Abdallah
An amendment to this paper has been published and can be accessed via the original article.
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Development of a sensitive and stable GC-MS/MS method for simultaneous determination of four N-nitrosamine genotoxic impurities in sartan substances J Anal Sci Technol (IF 1.66) Pub Date : 2021-01-08 Jie Liu; Bin Xie; Binliang Mai; Qiang Cai; Rujian He; Dong Guo; Zhifeng Zhang; Jun Fan; Weiguang Zhang
Recently, N-nitrosamines have been unexpectedly found in generic sartan products. Herein, we developed a sensitive and stable GC-MS/MS method with multiple reactions monitoring mode for the simultaneous determination of four N-nitrosamines in sartan substances, namely, N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosodibutylamine, and N-nitrosodiisopropylamine. The conditions of gas chromatography
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A new high-performance liquid chromatographic method for the quality control of bioconverted Mori Folium extracts with appropriate marker compounds related to antidiabetes J Anal Sci Technol (IF 1.66) Pub Date : 2021-01-05 Jin Hyeok Kim; Tae Jung Kim; Hyun June Kim; Chong Woon Cho; Seok Jin Kim; Hyun So Cho; Kyung Tae Kim; Jong Seong Kang
A HPLC method was developed to assess the enhanced bioactivity of bioconverted Mori Folium (MF) extract and to apply a quality-control system. Liquid-liquid extraction was applied to observe changes in chemical composition through enzymatic bioconversion. The ethyl acetate layer was used for quality control of the anti-diabetic functional MF product. A high-performance liquid chromatography method
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A sensitive HPLC-FLD method for the quantification of 6-O-demethylmenisporphine isolated from Menispermi Rhizoma in rat plasma J Anal Sci Technol (IF 1.66) Pub Date : 2021-01-04 Jinxia Wei; Jia Shao; Yanan Li; Yubo Li
To investigate the pharmacokinetics of 6-O-demethylmenisporphine, an oxoisoaporphine alkaloid with significant anti-tumor activities and isolated from Menispermi Rhizoma, a novel and sensitive HPLC assay was established for 6-O-demethylmenisporphine quantification in rat plasma. Peak responses were detected by a highly selective and sensitive fluorescence detector with 426-nm excitation and 514-nm
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LC-Q-TOF-MS driven identification of potential degradation impurities of venetoclax, mechanistic explanation on degradation pathway and establishment of a quantitative analytical assay method J Anal Sci Technol (IF 1.66) Pub Date : 2020-12-11 Dhruvisha Pokar; Amit Kumar Sahu; Pinaki Sengupta
Venetoclax is a selective orally active Bcl-2 protein inhibitor very recently approved by USFDA to treat chronic lymphocytic leukemia and other hematological malignancies. Postmarketing surveillance of any drug depends on its acceptability based on risk to benefit ratio. When risk outweighs the benefits, withdrawal of an already marketed drug is warranted. Presence of impurity is the primary cause
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A new liquid phase microextraction method-based reverse micelle for analysis of dexketoprofen in human plasma by HPLC-DAD J Anal Sci Technol (IF 1.66) Pub Date : 2020-12-09 Dönay Yuvali; Erkan Yilmaz; İbrahim Narin
A new liquid phase microextraction method was developed by used reverse micelle-based coacervates as microextraction agents for the separation of dexketoprofen (DKT) from human plasma before its determination by high-performance liquid chromatography with photodiode-array detection (HPLC-DAD). The change in the concentration of dexketoprofen in the plasma of the male and female patients was successfully
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Two-point normalization for reducing inter-laboratory discrepancies in δ17O, δ18O, and Δ′17O of reference silicates J Anal Sci Technol (IF 1.66) Pub Date : 2020-11-26 Nak Kyu Kim; Changkun Park; Minoru Kusakabe
The δ17O and δ18O values of a number of terrestrial minerals and rocks have been determined using laser fluorination method worldwide. For the comprehensive and congruous interpretation of oxygen isotope data, the δ-values should be normalized by the two-point method (i.e., the VSMOW-SLAP scale) to eliminate inter-laboratory bias. In this study, the δ17O and δ18O values of VSMOW and SLAP were measured
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Correction to: Attribution and identification of absorbed components by HPLC-DAD-ESI-MS after oral administration of Erhuang decoction J Anal Sci Technol (IF 1.66) Pub Date : 2020-11-24 Jinglong Wang; Dandan Zheng; Nan Xu; Chao Zhang; Yingzi Wang; Xiumei Sun; Zhaowang Zhang
An amendment to this paper has been published and can be accessed via the original article.
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Commentary on “time-dependent selected reaction monitoring-based GC-MS/MS method for estimation of genotoxic impurities in a new antibacterial agent: alalevonadifloxin mesylate” J Anal Sci Technol (IF 1.66) Pub Date : 2020-11-10 D. J. Snodin; A. Teasdale; D. P. Elder
The references cited in this article to justify the analysis of alkyl mesylates in alalevonadifloxin mesylate (ALA) are considered totally inappropriate since they all present evidence showing that such esters are not formed during the synthesis of a sulfonic-acid salt using an alcohol as solvent. Relevant mechanistic and kinetic data, first published over a decade ago, demonstrate that no alkyl-sulfonate
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Application of Plackett-Burman and central composite designs for screening and optimization of factor influencing the chromatographic conditions of HPTLC method for quantification of efonidipine hydrochloride J Anal Sci Technol (IF 1.66) Pub Date : 2020-11-05 Suraj R. Chaudhari; Atul A. Shirkhedkar
We report here an analytical method for expeditious estimation of efonidipine hydrochloride in tablet formulation with statistical screening and optimization designs using NP-HPTLC. TLC silica gel 60 F254 aluminum plates and ethyl acetate to dichloromethane to triethylamine (3:2:0.5 v/v) were chosen for chromatographic separation of efonidipine hydrochloride. The Rf value for efonidipine hydrochloride
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Preparation and characterization of different geometrical shapes of multi-bore hollow fiber membranes and application in vacuum membrane distillation J Anal Sci Technol (IF 1.66) Pub Date : 2020-10-23 Elham M. El-Zanati; Eman Farg; Esraa Taha; Ayman El-Guindi; Heba Abdallah
Multi-bore hollow fiber membranes were prepared through phase inversion spinning process using new locally designed spinnerets of various geometrical shapes. The spun cylindrical-like, rectangular or ribbon-like, and triangular-like are prepared, dried, and characterized by scanning electronic microscope. Fibers of circular (seven, five, and four bores) shape, rectangular of five bores, and triangular
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Enhanced differentiation of isomeric RNA modifications by reducing the size of ions in ion mobility mass spectrometric measurements J Anal Sci Technol (IF 1.66) Pub Date : 2020-10-20 Hongzhou Wang; Daniel A. Todd; Norman H. L. Chiu
With the ability to differentiate different molecular sizes, ion mobility spectrometry (IMS) has great potentials in the analysis of isomeric compounds. However, due to the lack of sensitivity and resolution, IMS has not been commonly used. To address the issue on resolution, the goals of this study are to explore a more effective way to perform IMS by reducing the size of ions prior to the IM measurements
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Gold determination in soil by ICP-MS: comparison of sample pretreatment methods J Anal Sci Technol (IF 1.66) Pub Date : 2020-10-15 Xiaodan Tang; Bing Li; Jilong Lu; Hongyan Liu; Yuyan Zhao
At present, the direct gold determination in geological samples by inductively coupled plasma mass spectrometry (ICP-MS) is still an arduous challenge due to both spectral and background interferences. It is very important and necessary to study the pretreatment processes; therefore, the polyurethane foam treatment and sample digestion methods are explored and compared here. The experimental results
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Method validation and measurement uncertainty of possible thirty volatile organic compounds (VOCs) presented in the polyethylene present in bottled drinking waters sold in Turkey J Anal Sci Technol (IF 1.66) Pub Date : 2020-10-08 Barış Güzel; Oltan Canli
This study was actualized for the simultaneous determination of possible thirty VOCs presented in drinking waters in Turkey by direct injection to purge and trap (PT) gas chromatography-mass spectrometry (GC-MS). It consists of selectivity, linearity, the limit of detection (LOD) and limit of quantification (LOQ), accuracy (recovery), precision, trueness, and measurement uncertainty studies. In linearity
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Potential antibiofilm activity of farnesol-loaded poly(DL-lactide-co-glycolide) (PLGA) nanoparticles against Candida albicans J Anal Sci Technol (IF 1.66) Pub Date : 2020-10-03 Bükay Yenice Gürsu
Candida species are ubiquitous fungal pathogens and are the most common causes of mucosal and invasive fungal infections in humans. Especially Candida albicans commonly resides as a commensal in the mucosal tissues of approximately half of the human population. When the balance of the normal flora is disrupted or the immune defenses are compromised, Candida species can become pathogenic, often causing
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Quantitative carbon distribution analysis of hydrocarbons, alcohols and carboxylic acids in a Fischer-Tropsch product from a Co/TiO2 catalyst during gas phase pilot plant operation J Anal Sci Technol (IF 1.66) Pub Date : 2020-09-25 Roy Partington; Jay Clarkson; James Paterson; Kay Sullivan; Jon Wilson
Comprehensive two-dimensional gas chromatography (GCxGC) analysis for 1-alcohols and gas chromatography–mass spectrometry (GC-MS) analysis for carboxylic acids, derivatised as their methyl esters, have been applied to liquid and wax Fischer-Tropsch (FT) hydrocarbon products. These methods in combination with conventional one-dimensional gas chromatography (GC) analysis of the aqueous, gaseous, liquid
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Thermodynamic and detailed kinetic study of the formation of orthophthalaldehyde-agmatine complex by fluorescence intensities J Anal Sci Technol (IF 1.66) Pub Date : 2020-09-10 Khémesse Kital; Moumouny Traoré; Diégane Sarr; Moussa Mbaye; Mame Diabou Gaye Seye; Atanasse Coly; François Delattre; Alphonse Tine
The aim of this work is to determine the thermodynamic parameters and the kinetics of complex formation between orthophthalaldehyde (OPA) and agmatine (AGM) in an alkaline medium (pH 13). Firstly, the association constant (Ka) between orthophthalaldehyde and agmatine was determined at different temperatures (between 298 K and 338 K) with a step size of 10 K. Secondly, the thermodynamic parameters such
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Correction to: Intravenous patient-controlled analgesia: in vitro stability profiles of mixtures containing fentanyl, hydromorphone, oxycodone, nefopam, ondansetron, and ramosetron J Anal Sci Technol (IF 1.66) Pub Date : 2020-09-09 Chung Hun Lee; Ah Rahn Kim; Mi Kyoung Lee; Jung Suk Oh; Dong Kyu Lee; Sang Sik Choi
An amendment to this paper has been published and can be accessed via the original article.
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Organic polymer monolithic columns with incorporated bare and cyano-modified fumed silica nanoparticles for use in hydrophilic interaction liquid chromatography J Anal Sci Technol (IF 1.66) Pub Date : 2020-09-04 Nisansala Ganewatta; Ziad El Rassi
This research article presents the preparation and characterization of monolithic columns with incorporated bare fumed silica nanoparticles (FSNPs) and cyano-modified FNSPs (CN-FSNPs) and their subsequent use in hydrophilic interaction liquid chromatography (HILIC) of neutral, polar, and low molecular weight solutes. The monolithic support was based on the in situ polymerization of glyceryl monomethacrylate
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Attribution and identification of absorbed components by HPLC-DAD-ESI-MS after oral administration of Erhuang decoction J Anal Sci Technol (IF 1.66) Pub Date : 2020-08-28 Jinglong Wang; Dandan Zheng; Nan Xv; Chao Zhang; Yingzi Wang; Xiumei Sun; Zhaowang Zhang
To realize the attribution and identification of absorbed components in rat serum after oral administration of Erhuang decoction prepared by semi-bionic enzyme extraction method, the fingerprints of serum samples were established using a HPLC-DAD-ESI-MS method. Thirty-two peaks in Erhuang decoction and 24 peaks in rat serum after oral administration of Erhuang decoction were detected. Among the 24
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Quantitative analyses of essential fatty acids in cereals and green vegetables by isotope dilution-gas chromatography/mass spectrometry J Anal Sci Technol (IF 1.66) Pub Date : 2020-08-25 Sunyoung Lee; Dong Kyu Lim; Song-Yee Baek; Dongwon Seo; Jong-Su Park; Byung-Man Kwak; Jongeun Won; Joonhee Lee; Byungjoo Kim
Abstract An analytical method for the accurate determination of essential fatty acids in cereals and green vegetables is established based on isotope dilution-gas chromatography/mass spectrometry (ID-GC/MS). In this approach, 13C-labeled fatty acids were added as internal standards to the samples prior to the sample preparation. Repeatability and reproducibility for the analyses of the essential fatty
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Rapid determination of S-(+)-linalool in leaf of Cinnamomum osmophloeum ct. linalool using ultrasound-assisted microextraction J Anal Sci Technol (IF 1.66) Pub Date : 2020-08-14 Ting-Kuang Chang; Chun-Ya Lin; Ying-Ju Chen; Ting-Feng Yeh; Shang-Tzen Chang
Cinnamomum osmophloeum ct. linalool is one chemotype of indigenous cinnamon in Taiwan. Its leaf essential oil (LEO) and main component S-(+)-linalool both possess great anxiolytic activities. The aim of this study was to establish ultrasound-assisted microextraction (UAME) for extracting LEO from C. osmophloeum ct. linalool. The absolute content of S-(+)-linalool and chemical composition of LEO were
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On-spot quantification of modafinil in generic medicines purchased from the Internet using handheld Fourier transform-infrared, near-infrared and Raman spectroscopy J Anal Sci Technol (IF 1.66) Pub Date : 2020-08-13 Sulaf Assi; Iftikhar Khan; Aaron Edwards; David Osselton; Hisham Al-Obaidi
Poor quality medicines represent an expanding global public health threat facilitated by the Internet. A recent survey showed that one in five students have used modafinil to enhance learning ability mainly purchased from Internet sources. The aim of this work was to develop on-the-spot and simple methods for the quantification of modafinil in generic medicines using Fourier transform-infrared (FTIR)
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Method development for acetyl octapeptide-3 analysis by liquid chromatography-tandem mass spectrometry J Anal Sci Technol (IF 1.66) Pub Date : 2020-08-12 Moongi Ji; Hyeon-Seong Lee; Youngbae Kim; Chan Seo; Subin Choi; Songjin Oh; Jeuk Min; Hyung-Jin Park; Jung Dong Kim; Do Hyeon Jeong; Man-Jeong Paik
Acetyl octapeptide-3 (SNAP-8) is an antiaging peptide that is more effective than acetyl hexapeptide-3, which is more stable than botulinum toxin and effectively relieves facial wrinkles. Products containing SNAP-8 such as patch are producing, but analytical method has not been reported to determination of SNAP-8. Mobile phase, collision energy, and desolvation line temperature were optimized, and
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Electron microscopic and spectroscopic analysis of airborne ultrafine particles: its effects on the cell viability J Anal Sci Technol (IF 1.66) Pub Date : 2020-08-08 Jeong Bin Yang; Hyung Joong Yun; Min Jeong Yeon; Dooil Jeoung; Kyoung-nam Jo; Hyun Suk Jung
Particulate matter (PM) is one of the most common air pollution sources causing various health-related conditions like cardiovascular diseases. However, among the three major PM types, UFPs have not yet been independently studied for their toxic effects on human health. In this study, we collected airborne dusts from Chuncheon-si, Republic of Korea, and analyzed it to understand the structural and
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Intravenous patient-controlled analgesia: in vitro stability profiles of mixtures containing fentanyl, hydromorphone, oxycodone, nefopam, ondansetron, and ramosetron J Anal Sci Technol (IF 1.66) Pub Date : 2020-08-04 Chung Hun Lee; Ah Rahn Kim; Mi Kyoung Lee; Jung Suk Oh; Dong Kyu Lee; Sang Sik Choi
Patient-controlled analgesia often involves combinations of multiple drugs. This study aimed to determine the stability of drug mixtures commonly used for intravenous patient-controlled analgesia. We examined four of the most commonly used drug combinations in intravenous patient-controlled analgesia at our institution. Mixtures contained fentanyl (400 μg), either oxycodone (10 mg) or hydromorphone
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exCTF simulator: Simulation tool for phase contrast transfer function for aberration-corrected transmission electron microscopy J Anal Sci Technol (IF 1.66) Pub Date : 2020-07-30 Sang-Chul Lee; Jong-Man Jeung; Sang-Gil Lee; Jin-Gyu Kim
The contrast transfer function (CTF) is an important principle in the field of transmission electron microscopy (TEM) imaging. It provides information on how the electron wave that interacted with a sample (in frequency domain) in an objective lens is transferred to the imaging system (in real space domain) depending on the effects of lens aberrations. Based on the CTF calculation, various useful results
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Low-cost, disposable colourimetric sensors for metal ions detection J Anal Sci Technol (IF 1.66) Pub Date : 2020-07-20 Giancarla Alberti; Camilla Zanoni; Lisa Rita Magnaghi; Raffaela Biesuz
In this work, two colourimetric sensors for metal ions detection are presented. The devices are obtained by fixing two classical dyes, Eriochrome Black T (EBT) and 1-(2-pyridylazo)-2-naphthol (PAN), on the commercial paper sheet “Colour Catcher®” (here named under the acronym CC) generally used in the washing machine to prevent colour run problems. The devices are optical sensors, since the indicator
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Comprehensive stability-indicating method development of Avanafil Phosphodiesterase type 5 inhibitor using advanced Quality-by-Design approach J Anal Sci Technol (IF 1.66) Pub Date : 2020-07-12 Mital Patel; Charmy Kothari
Avanafil (AV) is the phosphodiesterase (PDE) type 5 inhibitor drug used in erectile dysfunction, having pyrrolidine, pyrimidine, carboxamide, and chlorine as functional groups which can easily break by environmental changes and cause toxicity. Henceforth, in detail, HPLC stability study with the Quality-by-Design (QbD) approach is presented which leads to recommended storage conditions. The stability
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A new approach for urinary vanillylmandelic acid determination using eVol microextraction by packed sorbent coupled to liquid chromatography-tandem mass spectrometry J Anal Sci Technol (IF 1.66) Pub Date : 2020-07-08 Xin Xiong; Yuanyuan Zhang
Vanillylmandelic acid (VMA) is one of the most important catecholamine metabolites, and it is usually used to aid in diagnosis of pheochromocytoma and paraganglioma. A new digital control microextraction by packed sorbent (MEPS) procedure coupled to liquid chromatography-mass spectrometry (LC-MS/MS) method has been developed to determine VMA in human urine. We evaluated important parameters influencing
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Fast and simple selenium speciation by solid phase extraction and laser-induced breakdown spectroscopy J Anal Sci Technol (IF 1.66) Pub Date : 2020-07-07 Seon Hwa Lee; Seul-Woo Kwon; Yonghoon Lee; Sang-Ho Nam
The chemical properties including toxicity of selenium depend on the concentration and chemical structure present in the natural environment. Inorganic selenium is more toxic than organic selenium; thus, the accurate determination of inorganic selenium in various sample has been needed. HG-AAS, HPLC-ICP-MS, and GC-MS are the current methods for the determination of inorganic selenium. However, these
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Study of bioaccessibility of cobalt species in berries and seeds by mass spectrometry techniques J Anal Sci Technol (IF 1.66) Pub Date : 2020-07-07 Justyna Wojcieszek; Lena Ruzik
In recent years, açai berries (Euterpe Oleracea M.), goji berries (Lycium barbarum L.), bilberries (Vaccinium myrtillus L.), and chia seeds (Salvia hispanica L.) have increased interest worldwide due to their nutritional value and health benefits. In the present study, SEC-ICP-MS and μ-HPLC-ESI-MS/MS were used for the investigation of cobalt speciation and evaluation of its bioaccessibility in these
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A portable standalone wireless electric cell-substrate impedance sensing (ECIS) system for assessing dynamic behavior of mammalian cells J Anal Sci Technol (IF 1.66) Pub Date : 2020-06-30 Uvanesh Kasiviswanathan; Suruchi Poddar; Chandan Kumar; Satyabrata Jit; Sanjeev Kumar Mahto; Neeraj Sharma
In this study, we have developed a wireless, portable, standalone, and simple electric cell-substrate impedance sensing (ECIS) system to analyze in-depth functional aspects of cellular functions on the surface of a co-planar metal electrode coated on conventional glass substrate using a low-cost circuitry and correlated it with an equivalent electrical circuit (EEC) model. Low-cost circuitry was used
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1H-31P home-built solid-state NMR probe with a scroll coil for 400-MHz NB magnet for biological lossy sample J Anal Sci Technol (IF 1.66) Pub Date : 2020-06-25 Ji-Ho Jeong; Minseon Kim; Jinyoung Son; Yongae Kim
Phosphorus is one of the most important constituents of human biofilms, in particular lipid bilayer packing, phase transition (gel phase, physiological liquid crystal phase, ripple phase, non-biphasic), lipid head group orientation/mechanics, and pure lipid bilayers. Phosphorus observations in biofilms play an important role in the study of the interaction of many types of proteins and biofilms in
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Accurate quantification of EVT201 and its two metabolites in human urine using UHPLC-MS/MS method with solid phase extraction J Anal Sci Technol (IF 1.66) Pub Date : 2020-06-23 Congya Zhou; Xiaofeng Cai; Yuanyuan Zhang; Chunmiao Pan; Chuanzhen Wang; Suodi Zhai; Li Yang; Shuangpeng Zhu; Xianhua Zhang
A sensitive and accurate ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for the determination of EVT201 and its two metabolites, Ro46-1927 and Ro18-5528, in human urine. Different sample preparation methods were compared, and solid-phase extraction (SPE) was finally employed. Separation conditions and mass spectrometry parameters
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Time-dependent selected reaction monitoring-based GC-MS/MS method for estimation of genotoxic impurities in new antibacterial agent: alalevonadifloxacin mesylate J Anal Sci Technol (IF 1.66) Pub Date : 2020-06-17 Vinod K. Ahirrao; Rajiv A. Jadhav; Vipul P. Rane; Harshal R. Bhamare; Ravindra D. Yeole
Alalevonadifloxacin mesylate (ALA), pro-drug of levonadifloxacin is a new antibiotic approved in India to treat infections caused by Gram-positive bacteria. Alkyl mesylates (AMs) are known genotoxic impurities (GTI’s) formed in drug substances isolated as mesylate salts. Time-dependent selected reaction monitoring (t-SRM)-based gas chromatography tandem mass spectrometry (GC-MS/MS) method has been
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Reactive-oxygen-species-mediated mechanism for photoinduced antibacterial and antiviral activities of Ag3PO4. J Anal Sci Technol (IF 1.66) Pub Date : 2020-06-11 Youngsik Seo,Keunchun Park,Yonggun Hong,Eun Sik Lee,Sang-Soon Kim,Yong-Tae Jung,Heonyong Park,Chian Kwon,Young-Sik Cho,Young-Duk Huh
Cubic-shaped Ag3PO4 crystals with a mean size of 1 μm were synthesized by a precipitation method from a mixed solution of AgNO3, Na2HPO4, and triethanolamine. The antibacterial activities against Escherichia coli, Listeria innocua, and Pseudomonas syringae DC3000 in both the absence and presence of Ag3PO4 under dark conditions and in the presence of Ag3PO4 under red-light (625 nm) and blue-light (460 nm)
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Development and validation of an LC-MS/MS method for monitoring larotrectinib, a tropomyosin-related kinase inhibitor, in mouse and human plasma and application to pharmacokinetic studies J Anal Sci Technol (IF 1.66) Pub Date : 2020-06-03 Yoon-Jee Chae; Yoo-Kyung Song; Song-Hee Chae; Min Ju Kim; Jong Soon Kang; Jae-Young Lee; Tae-Sung Koo; Kyeong-Ryoon Lee
Larotrectinib is an orally administered drug and the first and only selective pan-tropomyosin receptor kinase (TRK) inhibitor in clinical development to treat cancer patients harboring a neurotrophic receptor tyrosine kinase gene fusion. In this study, an analytical method to quantify the TRK inhibitor in mouse and human plasma was developed and validated using LC-MS/MS following protein precipitation
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UHPLC-MS/MS profiling of histidine and bile acid metabolism in human gastric fluid for diagnosis of gastric diseases J Anal Sci Technol (IF 1.66) Pub Date : 2020-06-03 Wonwoong Lee; Jinhee Um; Keon-hee Ko; Yong Chan Lee; Bong Chul Chung; Jongki Hong
Bile acids (BAs) are synthesized in the liver and can mediate homeostasis and various metabolism processes in the human body. Their levels in the gastrointestinal tract are closely related to various gastrointestinal diseases. In particular, farnesoid X receptor activated by free BAs is associated with overexpression of histidine decarboxylase in tumorigenesis. Therefore, comprehensive profiling of
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A simplified LC−MS/MS approach for simultaneous quantification and pharmacokinetics of five compounds in rats following oral administration of Gastrodia elata extract J Anal Sci Technol (IF 1.66) Pub Date : 2020-05-29 Jiajia Dong; De Ji; Lianlin Su; Fengyang Zhang; Huangjin Tong; Chunqin Mao; Tulin Lu
To support the multicomponent pharmacokinetics of Gastrodia elata, a rapid, simple, and sensitive ultra-performance liquid chromatography tandem with mass spectrometry (LC–MS/MS) approach was established for simultaneous quantification of gastrodin, parishin A, parishin B, parishin C, and parishin E. Five compounds were extracted from plasma by using one-step protein precipitation. The chromatographic
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Optimization of pH as a strategy to improve enzymatic saccharification of wheat straw for enhancing bioethanol production J Anal Sci Technol (IF 1.66) Pub Date : 2020-05-26 M. O. Abdulsattar; J. O. Abdulsattar; G. M. Greenway; K. J. Welham; S. H. Zein
In this work, wheat straw (WS) was used as a lignocellulosic substrate to investigate the influence of pH on enzymatic saccharification. The optimum enzymatic hydrolysis occurred at pH range 5.8–6.0, instead of 4.8–5.0 as has been widely reported in research. Two enzymes cocktails, Celluclast® 1.5 L with Novozymes 188, Cellic® CTec2 and endo-1,4-β-xylanase, were used for the pH investigation over a
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Retraction Note: Method development, validation, and stability studies of teneligliptin by RP-HPLC and identification of degradation products by UPLC tandem mass spectroscopy J Anal Sci Technol (IF 1.66) Pub Date : 2020-05-19 T. N. V. Ganesh Kumar; S. Vidyadhara; Niteen Ashok Narkhede; Y. Sai Silpa; M. Rajya Lakshmi
An amendment to this paper has been published and can be accessed via the original article.
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Microscopic and chemical analysis of room temperature UV laser annealing of solution-based zinc-tin-oxide thin films J Anal Sci Technol (IF 1.66) Pub Date : 2020-05-15 Ji-Hwan Kwon; Seunghoon Jang; Hyuk Jin Kim; Beom Soo Joo; Kwang Nam Yu; Eunjip Choi; Moonsup Han; Jong Hyuk Park; Young Jun Chang
As a promising transparent semiconducting oxide (TSO) candidate, zinc-tin-oxide (ZTO) thin films were fabricated by combining solution coating and ultraviolet (UV) laser annealing. Instead of external heating, an intense UV laser was applied to transform sol-gel coatings via surface heating and photoexcited dissociation into oxide films. The laser-induced phase transformation was extensively investigated
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NMR structure and bactericidal activity of KR-12 analog derived from human LL-37 as a potential cosmetic preservative J Anal Sci Technol (IF 1.66) Pub Date : 2020-05-14 Hyosuk Yun; Hye Jung Min; Chul Won Lee
KR-12 was derived from the human antimicrobial peptide, LL-37. KR-12 maintains the antimicrobial activity of LL-37 and has low toxicity against human cells, thereby showing a high potential for various applications. In this study, the three-dimensional structure of KR-12 analog (KR-12-pa) was determined by solution NMR spectroscopy. The NMR structure of KR-12-pa revealed a nearly perfect amphipathic
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Glutathione-capped Syzygium cumini carbon dot-amalgamated agarose hydrogel film for naked-eye detection of heavy metal ions J Anal Sci Technol (IF 1.66) Pub Date : 2020-04-24 Jigna R. Bhamore; Tae Jung Park; Suresh Kumar Kailasa
Development of a facile and sensitive analytical tool for the detection of heavy metal ions is still a challenging task because of interference from other chemical species. In this work, glutathione (GSH)-capped Syzygium cumini carbon dots (CDs) have been integrated with agarose hydrogel film and used as an amalgamated solid probe for sensing of different metal ions (Pb2+, Fe3+, and Mn2+). The synthesis
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Absolute quantification of terpenes in conifer-derived essential oils and their antibacterial activity J Anal Sci Technol (IF 1.66) Pub Date : 2020-04-19 Martina Delia Allenspach; Claudia Valder; Christian Steuer
A simple, robust, and precise method for the absolute quantification of the terpenes α-pinene, camphene, β-pinene, 3-carene, limonene, bornyl acetate, β-caryophyllene, and borneol was developed using gas chromatography coupled to a flame ionization detector (GC-FID) and validated according to the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use. The
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An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study J Anal Sci Technol (IF 1.66) Pub Date : 2020-04-06 Xiuxue Li; Lijun Wang; Xiaoling Jia; Chuanlong Guo; Chao Li; Jiajia Zhang; Dayong Shi
Bromophenol-thiosemicarbazone hybrid was a novel synthetic brominated anticancer compound with two bromine atoms. Bromophenol-thiosemicarbazone hybrid showed considerable selective inhibitory activity against PARP1 (IC50 = 29.5 nmol/L). UHPLC-TOF-MS was used to establish a new method to quantify bromophenol-thiosemicarbazone hybrid bio-samples for indispensable quantitation analysis in further extensive
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Colorimetric detection of Cr3+ based on gold nanoparticles functionalized with 4-mercaptobenzoic acid J Anal Sci Technol (IF 1.66) Pub Date : 2020-03-13 Zhikun Zhang; Xiaojie Ye; Qingqing Liu; Yumin Liu; Runjing Liu
Herein, we report the construction of a colorimetric probe used to detecting Cr3+ ions in aqueous solution based on functionalized gold nanoparticles. We investigated 4-mercaptobenzoic acid, 4-nitrobenzenethiol, and a mixture of 4-mercaptobenzoic acid and 4-nitrobenzenethiol as ligands for Cr3+ ions to functionalize the gold nanoparticles, respectively. The results showed that the three probes were
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Improvement of 40Ar/39Ar age determinations for Quaternary basaltic rocks by eliminating the peak suppression effect J Anal Sci Technol (IF 1.66) Pub Date : 2020-02-20 Jeongmin Kim; In-Hwa Cho
The peak suppression effect, which suppresses the argon isotope signal due to the incomplete cleaning of gas from geological samples during measurement, is found in volatile-rich samples using the ARGUS VI noble gas mass spectrometer and its sample preparation system. Such effect hampers getting the precise isotope ratio essential for the 40Ar/39Ar age calculation. The addition of one hot-getter and
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Accelerating the computation for real-time application of the sinc function using graphics processing units J Anal Sci Technol (IF 1.66) Pub Date : 2020-02-15 Sangwoo Kim; Chulhyun Lee
In magnetic resonance imaging, the fidelity of image reconstruction is an important criterion. It has been suggested that the infinite-extent sinc kernel is the ideal interpolation kernel for ensuring the reconstruction quality of non-Cartesian trajectories. However, the application of the sinc function has been limited owing to its computational overheads. Recently, graphics processing units (GPUs)
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Simultaneous removals of cadmium(II) ions and reactive yellow 4 dye from aqueous solution by bone meal-derived apatite: kinetics, equilibrium and thermodynamic evaluations J Anal Sci Technol (IF 1.66) Pub Date : 2020-02-13 Edwin A. Ofudje; Idowu A. Adeogun; Mopelola A. Idowu; Sarafadeen O. Kareem; Nelly A. Ndukwe
The simultaneous removal of Cadmium ions and reactive yellow 4 dye (RY4 dye) by bone meal-derived apatite (BMDA) were investigated in a batch process. The structural elucidation of the prepared BMDA was done using TEM, XRD, FT-IR and EDX to evaluate the structures of the adsorbent. Different experimental features such as the agitation time, BMDA dosage, temperature, initial adsorbate concentration
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Colorimetric determination of amaranth followed enrichment and separation using buoyant adsorbents J Anal Sci Technol (IF 1.66) Pub Date : 2020-02-07 Shu Wu; Yuanyuan Yu; Cengceng Zhang; Fang Chen
A buoyant solid-phase extraction adsorbent was prepared by sodium alginate-coated hollow glass microspheres (HGMs) modified with 3-aminopropyltrimethoxysilane (3-APTS) for the separation and enrichment of anionic dye amaranth. After adsorbing amaranth, these low-density adsorbents can float on the surface of the solution, so the separation between adsorbents and substrates can be carried out by flotation
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Diamine oxidase-modified screen-printed electrode for the redox-mediated determination of histamine J Anal Sci Technol (IF 1.66) Pub Date : 2020-02-05 Ricarda Torre; Estefanía Costa-Rama; Henri P. A. Nouws; Cristina Delerue-Matos
Histamine is an important biogenic amine because of its role in immune responses and the regulation of physiological functions. It is also used as a food freshness indicator, so its maximum concentration in fish is legally regulated. Although several robust and sensitive methods for histamine detection are already available, it continues to be a challenge to develop simple and portable devices that
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Dual-label time-resolved fluoroimmunoassay for simultaneous measurement of human epidermal growth factor receptor 2 and human epididymis protein 4 in serum J Anal Sci Technol (IF 1.66) Pub Date : 2020-01-16 Yi Zhang; Ke Wang; Ying Zhao; Jun Fan; Tingting Han; Yu-an Si; Bin Zhou; Jue Zhang; Zhigang Hu; Minhao Xie
In this study, a novel dual-label time-resolved fluoroimmunoassay (TRFIA) is described for simultaneous quantification of human epidermal growth factor receptor 2 (HER-2) and human epididymis protein 4 (HE4) in serum to screen gynecologic cancers. A double-antibody sandwich TRFIA was introduced with europium and samarium chelates to simultaneously detect the concentrations of HER-2 and HE4. Under optimal
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Fabrication of novel polymer-modified graphene-based electrochemical sensor for the determination of mercury and lead ions in water and biological samples J Anal Sci Technol (IF 1.66) Pub Date : 2020-01-10 Chenthattil Raril; Jamballi G. Manjunatha
This paper presents the application of polyglycine-modified graphene paste electrode (PGMGPE) for the electrochemical detection of Hg (II) and Pb (II) ions in the water and biological samples. The developed electrode was characterized by field emission scanning electron microscopy. Electrochemical techniques such as cyclic voltammetry and differential pulse voltammetry were used to study the behavior
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Rapid determination of aminoglycosides in pharmaceutical preparations by electrospray ionization mass spectrometry J Anal Sci Technol (IF 1.66) Pub Date : 2020-01-04 Freneil B. Jariwala; John A. Hibbs; Iryna Zhuk; Svetlana A. Sukhishvili; Athula B. Attygalle
Aminoglycosides are broad-spectrum antibiotics often employed to combat Gram-negative bacterial infections. A technique based on electrospray-ionization mass spectrometry (ESI-MS) was developed for rapid determination of aminoglycosides. This method, which does not require prior chromatographic separation, or derivatization and extensive sample preparation steps, was deployed to estimate gentamicin
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Revisited digestion methods for trace element analysis in human hair J Anal Sci Technol (IF 1.66) Pub Date : 2019-12-31 Woo-Jin Shin; Minkyoung Jung; Jong-Sik Ryu; Jihwan Hwang; Kwang-Sik Lee
The human hair is a potential material for assessing the exposure to environmental contaminants and tracing human mobility. Although various digestion methods have been proposed for determining trace elements in the human hair, there is no consensus about the best method among them yet. We examined five different methods in order to determine the best method yielding the most accurate and precise data
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Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry J Anal Sci Technol (IF 1.66) Pub Date : 2019-12-30 Ahmed Hemdan; Maya S. Eissa
Application of green solvents for developing green analytical methodologies has grown dramatically in the past few years. The “more hazardous reagents” are replaced by more “environment-friendly solvents” without affecting method performance. In the present study, two simple and accurate chromatographic methods were developed and validated for determination of the new antiviral combination sofosbuvir
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Observation of magnetic susceptibility changes within the thalamus: a comparative study between healthy and Parkinson’s disease afflicted cynomolgus monkeys using 7 T MRI J Anal Sci Technol (IF 1.66) Pub Date : 2019-12-29 Sangwoo Kim; Youngjeon Lee; Chang-Yeop Jeon; Yeung Bae Jin; Sukhoon Oh; Chulhyun Lee
Although the thalamus is known to modulate basal ganglia function related to motor control activity, the abnormal changes within the thalamus during distinct medical complications have been scarcely investigated. In order to explore the feasibility of assessing iron accumulation in the thalamus as an informative biomarker for Parkinson’s disease (PD), this study was designed to employ quantitative
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Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals J Anal Sci Technol (IF 1.66) Pub Date : 2019-12-21 Nagaraju Rajendraprasad; Kanakapura Basavaiah
Lisinopril (LNP) is an angiotensin-converting enzyme inhibitor used as anti-hypertensive, cardiovascular, in anti-prophylactic and anti-diabetic nephropathy drug. Development of two new, simple, low cost, and selective membrane-based ion-selective electrodes has been proposed for the determination of LNP in pharmaceuticals. The electrodes are based on poly(vinyl)chloride membrane doped with LNP-phosphotungstic
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