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New development of compact magnetic separator for on-site material screening in various geological survey J Anal Sci Technol (IF 2.4) Pub Date : 2024-03-18 So Jinnouchi, Chiaki Uyeda, Keiji Hisayoshi, Gen Takayama, Kentaro Terada
Magnetic separation has been recognized as a valuable technique for extracting or separating target materials from mixed heterogeneous particles. In conventional geological research, it has been used to separate ferro- and ferri-magnetic minerals such as Fe–Ni metal, magnetite and ilmenite. Recently, a mixture of diamagnetic and weak paramagnetic particles has been successfully separated into groups
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Molecularly imprinted polymers as solid-phase and dispersive solid-phase extraction sorbents in the extraction of antiretroviral drugs in water: adsorption, selectivity and reusability studies J Anal Sci Technol (IF 2.4) Pub Date : 2024-03-18 Thabiso Xolo, Precious Mahlambi
The antiretroviral drugs (ARVDs) have been reported to be among the emerging water pollutants as a results attention is being paid on their analysis. This work therefore explored for the first time the multi-template MIP for the selective removal of selected ARVDs (abacavir, efavirenz and nevirapine) in wastewater, river water and tap water. The adsorption studies of a multi-template MIP were conducted
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Microanalysis and mineralogy of Asian and Saharan dust J Anal Sci Technol (IF 2.4) Pub Date : 2024-03-13 Gi Young Jeong
Mineral dust is transported over long distances from desert sources, interacting with Earth environments. The mineralogy and microstructures of individual dust particles are required to understand the interactions. Here, I summarize recent findings from electron microscopy of dust particles, focusing on Asian and Saharan dust. Dust particles are heterogeneous mixtures of clay and nonclay minerals.
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Geochemical and cosmochemical application of microanalysis J Anal Sci Technol (IF 2.4) Pub Date : 2024-03-08 Yuri Amelin, Hiroshi Hidaka
The Special Collection of papers presented in this volume features the proceedings of the Korea-Japan Joint Conference on the Geochemical and Cosmochemical Applications of Microanalysis that was hosted by the Korea Basic Science Institute, and was held in Ochang, South Korea, in June 2023. Precision of chemical and isotopic analysis in geosciences is constrained by the number of atoms and molecules
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Simultaneous determination of ethyl glucuronide, cocaine, cocaethylene, and benzoylecgonine in hair by using LC–MS/MS J Anal Sci Technol (IF 2.4) Pub Date : 2024-03-01 Dong Won Shin, Seon Yeong Kim, Sung Ill Suh, Jin Young Kim
Alcohol and cocaine (COC) are commonly co-used drugs that cause addiction and have harmful effects. Their abuse may threaten the health of the abuser and public safety by causing serious accidents or crimes. The recidivism rate of drug-related crimes closely correlates with alcoholism. Several incidences of alcohol consumption in combination with drug abuse have been reported. Here, liquid chromatography
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Metabolomics characterization of two saffron from Iran and China using GC–MS and LC–MS methods J Anal Sci Technol (IF 2.4) Pub Date : 2024-02-28 Donglin Li, Wenhui Zuo, Shuo Ma, Renjie Li, Zhenfeng Ye
Saffron is a medicinally important species of the Iridaceae family. Saffron’s quality depends on the concentration of secondary metabolites. In this study, GC–MS and LC–MS were utilized to dissect the different metabolites profile of two saffron produced in Iran and China. As a result, a total of 325 differential metabolites (237 from LC–MS, 88 from GC–MS) were identified. These differential metabolites
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Method development for 14C-labeling of IgG antibodies in preparation for clinical trials J Anal Sci Technol (IF 2.4) Pub Date : 2024-02-27 Sooyoung Kim, Jae-Hwan Kwak, Jae-Kyung Jung, Soonsil Hyun
Carbon-14 (14C) labeling is a standard technology for tracing molecules and providing their pharmacokinetic profiles. However, its primary focus has been on small molecules, with limited application to biomacromolecules. Particularly in the development of new biological entities (NBE), the utilization of microdosing with a 14C-labeled biomacromolecule proves beneficial in the early stages of drug development
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Novel plasma-polymerized coating facilitates HeLa cell spheroid formation, exerting necroptosis via β-cyclodextrin-encapsulated resveratrol J Anal Sci Technol (IF 2.4) Pub Date : 2024-02-16 Sujeong Jang, Namwuk Baek, Youngsik Seo, Hyuna Lim, Donggeun Jung, Heonyong Park
Beta-cyclodextrins (β-CDs) comprise a pore for accommodating resveratrol (Res), thereby boosting its bioavailability. Res-incorporated β -CD (Res/CD) may be cytotoxic against both normal and cancer cells. Herein, we examined whether Res/CD exhibits anticancer activity against tumor spheroids, similar to in vivo tumor mass. To prepare three-dimensional spheroids, 1,1,1,3,5,7,7,7 octamethyl-3,5-bis(trimethylsiloxyl)
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Artificial intelligence and quantum cryptography J Anal Sci Technol (IF 2.4) Pub Date : 2024-02-09 Petar Radanliev
The technological advancements made in recent times, particularly in artificial intelligence (AI) and quantum computing, have brought about significant changes in technology. These advancements have profoundly impacted quantum cryptography, a field where AI methodologies hold tremendous potential to enhance the efficiency and robustness of cryptographic systems. However, the emergence of quantum computers
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Glyphosate detection via a nanomaterial-enhanced electrochemical molecularly imprinted polymer sensor J Anal Sci Technol (IF 2.4) Pub Date : 2024-02-02 Youssra Aghoutane, Hakan Burhan, Fatih Sen, Benachir Bouchikhi, Nezha El Bari
Glyphosate (GLY) is a widely used herbicide with an important role in agriculture. It effectively controls weeds, enhancing agricultural yield and product quality. However, its use raises significant concerns such as potential risks to non-target ecosystems and human health. In response to these concerns, we develop an electrochemical sensor with a molecularly imprinted polymer (MIP) and gold nanoparticles
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A simple and label-free proximity-catalytic hairpin reaction-based method for sensitive and miRNA analysis J Anal Sci Technol (IF 2.4) Pub Date : 2024-01-12 Yanyan Pan, Yehong Xu
Aberrant expression of microRNAs (miRNAs) has been shown to be linked to several crucial biological processes, including as carcinogenesis, metastasis, and progression. The advancement of innovative miRNA detection technologies can enhance the early detection of malignancies by merging with conventional diagnostic methods, such as ultrasound technology. Herein, we reported a simple, sensitive, and
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Nonlinear dimensionality reduction based visualization of single-cell RNA sequencing data J Anal Sci Technol (IF 2.4) Pub Date : 2024-01-11 Mohamed Yousuff, Rajasekhara Babu, Anand Rathinam
Single-cell multi-omics technology has catalyzed a transformative shift in contemporary cell biology, illuminating the nuanced relationship between genotype and phenotype. This paradigm shift hinges on the understanding that while genomic structures remain uniform across cells within an organism, the expression patterns dictate physiological traits. Leveraging high throughput sequencing, single-cell
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Quantification of bone surface textures: exploring a new method of ontogenetic ageing J Anal Sci Technol (IF 2.4) Pub Date : 2023-12-13 Jimmy de Rooij, Marleen Q. Vintges, Thim Zuidwijk, Carel T. H. Heerkens, Anne S. Schulp
Identification of ontogenetic age classes plays an important role in the fields of zoology, palaeontology and archaeology, where accurate age classifications of (sub)fossil remains are a crucial component for the reconstruction of past life. Textural ageing—the identification of age-related bone surface textures—provides a size-independent method for age assessment of vertebrate material. However,
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Synthesis and evaluation of small molecule-based derivatives as inhibitors of polo-box domain of polo-like kinase-1 J Anal Sci Technol (IF 2.4) Pub Date : 2023-11-27 Yeo Kyung La, Pethaiah Gunasekaran, Min Su Yim, Gong-Hyeon Lee, Yeon Sil Hwang, Kannan Damodharan, Mi-Hyun Kim, Jeong Kyu Bang, Eun Kyoung Ryu
Polo-like kinase 1 (Plk1) is an important mitotic protein. In particular, this protein is highly overexpressed in many types of tumors and has been identified as a potential biomarker for the treatment and diagnosis of tumors. Plk1 is composed of two domains, an N-terminal kinase domain and a C-terminal polo-box domain (PBD). Presently, inhibitors with improved selectivity and specificity for Plk1
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Deep learning image segmentation for the reliable porosity measurement of high-capacity Ni-based oxide cathode secondary particles J Anal Sci Technol (IF 2.4) Pub Date : 2023-11-21 Hee-Beom Lee, Min-Hyoung Jung, Young-Hoon Kim, Eun-Byeol Park, Woo-Sung Jang, Seon-Je Kim, Ki-ju Choi, Ji-young Park, Kee-bum Hwang, Jae-Hyun Shim, Songhun Yoon, Young-Min Kim
The optimization of geometrical pore control in high-capacity Ni-based cathode materials is required to enhance the cyclic performance of lithium-ion batteries. Enhanced porosity improves lithium-ion mobility by increasing the electrode–electrolyte contact area and reducing the number of ion diffusion pathways. However, excessive porosity can diminish capacity, thus necessitating optimizing pore distribution
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Simple, sensitive, and label-free miRNA analysis through strand displacement reaction integrating with G-quadruplex-based signal generation J Anal Sci Technol (IF 2.4) Pub Date : 2023-11-13 Hongmin Zhang, Jie Li, Hong Huang, Hao Wang, Sheng Qiu, Gangyi Yang
MicroRNAs (miRNAs) play a significant role in the pathogenesis of various diseases throughout biological processes, and the accurate detection of miRNA biomarkers holds great potential for early stage disease diagnosis and treatment. In this study, a novel method is developed to detect miRNA-21, a biomarker for drug-induced liver injury, by combining target sequence recycling with G-quadruplex-based
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Functional rolling circle amplification-based sensitive determination and low-speed centrifugation-based isolation of Staphylococcus aureus J Anal Sci Technol (IF 2.4) Pub Date : 2023-10-26 Yan Gao, Chaohui Li, Ying Wang, Xue Yu
The ability to quickly and accurately analyze Staphylococcus aureus (S. aureus) and isolate the bacteria in a simplified setting is crucial for the early identification and treatment of infectious illnesses. Here, we describe the development of a new aptamer-based detection and separation technique that combines Mg2+-dependent DNAzyme amplification cascades with catalytic hairpin assembly for enhanced
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Simultaneous determination of seven bile acids to study the effect of ivermectin on their plasma levels in rat by UHPLC–MS/MS J Anal Sci Technol (IF 2.4) Pub Date : 2023-10-16 T. V. Radhakrishna Mullapudi, Punna Rao Ravi, Ganapathi Thipparapu
Bile acids (BAs) are considered to be important diagnostic biomarkers to understand the pathophysiology of hepatobiliary and metabolic diseases. BAs regulate lipid and glucose metabolism by binding to farnesoid X receptor (FXR). To date, there were no reports on the effect of an exogenous FXR modulator, ivermectin (IVM), on the plasma BA profiles in rats. To explore the effect of IVM on plasma BA levels
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Analysis of iron-rich hydrochloric acid solutions for uranium, thorium, rare-earth elements and other heavy metals J Anal Sci Technol (IF 2.4) Pub Date : 2023-10-05 Beena Sunilkumar, M. Krishnakumar, A. A. Patwardhan
A simple solvent extraction method is described for the separation of trace elements including uranium (U), thorium (Th) and rare-earth elements (REEs) from industrially processed iron-rich hydrochloric acid solutions. Iron (Fe) causes severe spectral interference during the analysis of trace elements using inductively coupled plasma optical emission spectrometer (ICP-OES) and U by light-emitting diode
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Fluorescence determination of 3-MCPD by combining amino silica nanoparticles with fluorescein isothiocyanate J Anal Sci Technol (IF 2.4) Pub Date : 2023-10-02 Ting Xu, Zeng Qingru, Qing Fu, Zhaojie Wang, Xin Liu, Shensheng Xiao, Xiaoming Jiang, Yuepeng Lu, Zhiyong Gong, Yongning Wu, Min Fang
Using amino silica modified with fluorescein isothiocyanate (FITC), a quick fluorescence analysis technique is used for the detection of 3-monochloropropane-1,2-diol (3-MCPD). At 100 °C and pH 8.5, FITC-modified amino silica exhibits the lowest fluorescence intensity in the presence of 3-MCPD. This can predominantly be explained mostly explained by 3-MCPD’s capacity to occupy the amino group that FITC
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Urinary creatinine concentration and urine color as indicators of specimen validity test J Anal Sci Technol (IF 2.4) Pub Date : 2023-09-28 Jaehyeong Park, Nam Hee Kwon, Seon Yeong Kim, Beom Jun Ko, Jin Young Kim
In this study, the concentration of urinary creatinine (Cr) and urine color were analyzed, and a correlation obtained, to objectively verify normal urine samples prior to forensic drug testing. Cr was analyzed via a colorimetric method based on the Jaffé reaction using a Cobas C-311 analyzer (Roche SA, Basel, Switzerland; Hitachi, Tokyo, Japan). The Cr concentration for urine specimen validity testing
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4-Mercaptobenzoic acid-modified Au@Ag nanoparticle-based colorimetric Cr3+ ions detection in aqueous solution J Anal Sci Technol (IF 2.4) Pub Date : 2023-09-21 Zhikun Zhang, Heng Li, Dongan Guo, Cuixia Hu, Yumin Liu
Heavy metal ions pose a threat to both ecological balance and human health owing to the non-biodegradable and poisonous characteristics. A simple, convenient and rapid metal ion monitoring plays a significant role for eliminating metal ions pollution. In this work, we prepared 4-mercaptobenzoic acids (4-MBA)-functionalized silver-coated gold nanoparticles (Au@Ag NPs) as colorimetric probes to construct
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Correction: Antibiotic susceptibility of Staphylococcus aureus with different degrees of biofilm formation J Anal Sci Technol (IF 2.4) Pub Date : 2023-09-08 Hyo-Jung Shin, Sungtae Yang, Yong Lim
Correction to: J Anal Sci Technol (2021) 12:41 https://doi.org/10.1186/s40543-021-00294-2 Following the publication of the original article [1], the authors would like to add a reference and update the acknowledgements section. The reference and acknowledgements are given as follows: Acknowledgements This paper was modified and developed from the master's thesis of Hyo-Jung Shin. Reference Hyo-Jung
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Development of isotope dilution-liquid chromatography tandem mass spectrometry for the accurate determination of vitamin K1 in spinach and kimchi cabbage J Anal Sci Technol (IF 2.4) Pub Date : 2023-09-08 Hyeyoung Lee, Joonhee Lee, Honghee Lee, Byungjoo Kim
In the human body, vitamin K1 is important for bone and cardiovascular health and blood coagulation. To assess the correlation between vitamin K1 intake and health outcomes, the accurate determination of the amounts of vitamin K1 in green leafy vegetables, which are its major source in the diet, is needed. In this study, an accurate method for quantifying naturally occurring trans- and cis-vitamin
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Effective investigation of murine femoral bone development utilizing correlative light and electron microscopy (CLEM) J Anal Sci Technol (IF 2.4) Pub Date : 2023-09-04 Yong-Eun Kwon, Jung-Kyun Kim, Youn-Joong Kim, A. Reum Je, Hwanuk Guim, Jin-Gyu Kim
For effective investigation of the developing structure and chemistry of bone, comprehensive studies including compositional analysis can be achieved through the gradual observation from the micro- to nanometer scale via correlative light and electron microscopy (CLEM). This technique is particularly useful considering the complex hierarchical arrangement of bioapatite and collagen fibrils which may
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Laboratory evaluation of a prototype portable gas chromatograph (GC) with a flame ionization detector (FID) for toluene, ethylbenzene, and xylenes (TEX) analysis J Anal Sci Technol (IF 2.4) Pub Date : 2023-08-30 Seunghyeon Yang, Jeffrey Wickliffe, Gottfried Kibelka, Edward B. Overton, Claudiu T. Lungu, Jonghwa Oh
The standard method to evaluate human exposure to volatile organic compounds (VOCs) is in general performed by sampling the air on sorbents followed by liquid extraction and detection using laboratory gas chromatograph (GC). The conventional method is time and labor intensive and employs a toxic solvent which adds a risk factor as well as waste. Hence, there have been increasing demands for portable
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Ag+ colorimetric sensor based on graphene oxide/nano-platinum composite J Anal Sci Technol (IF 2.4) Pub Date : 2023-08-10 Yanping Qu, Ibrahim Yakub, Rubiyah Baini, WenShuo Hu, Lizhen Wang
With the development of society, pollution accidents occur more frequently, and the effects of toxic substances containing silver on human health and environment are increasingly extensive. Therefore, the real-time on-site monitoring of silver ions is urgently needed. Based on the catalase-like properties of graphene/nano-platinum composites and the coupling effect between Pt and Ag+, a simple, unlabeled
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Liquid chromatography-tandem mass spectrometry for pharmacokinetics evaluation of AZD5305, a selective PARP1 inhibitor, in mice J Anal Sci Technol (IF 2.4) Pub Date : 2023-08-09 Gi Ju Lee, Jin Woo Kim, Hae-In Choi, Jin Young Choi, Kwan Hyung Cho, Tae-Sung Koo
Poly (ADP-ribose) polymerase (PARP) inhibitors that are effective against ovarian and breast cancers with breast cancer susceptibility gene (BRCA) mutations have undesirable side effects, such as hematological toxicity. AZD5305, a selective PARP1 inhibitor currently in Phase 1/2 clinical trials, may avoid the side effects caused by PARP2. However, the in vivo pharmacokinetic characteristics of AZD5305
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Effect of central PxxP motif in amphipathic alpha-helical peptides on antimicrobial activity and mode of action J Anal Sci Technol (IF 2.4) Pub Date : 2023-08-09 Hyunhee Lee, Sungtae Yang, Sung-Heui Shin
Amphipathic α-helical peptides (AHPs) have shown potential as a therapeutic approach against multi-drug-resistant bacterial infections due to their broad-spectrum antimicrobial activity by disrupting bacterial membranes. However, their nonspecific interactions with membranes often result in cytotoxicity toward mammalian cells. Previous studies have shown that a PxxP motif near the middle of cathelicidin-derived
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Backbone assignment and inhibitor binding studies of IL-33 mutants by NMR spectroscopy J Anal Sci Technol (IF 2.4) Pub Date : 2023-07-24 Minhee Kang, Soyun Kim, Chan Haeng Heo, Sang-Hyun Son, Youngjoo Byun, Young Ho Jeon
Interleukin-33 (IL-33) is an IL-1 family protein that induces a type-2 immune response. IL-33 is constitutively expressed in epithelial cells and released in response to the cell damage or stimulation by an allergen. The secreted protein is activated when the N-terminal domain is cleaved by a protease, and the active form signals downstream immune cells, such as eosinophils, by binding to the heterodimeric
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Real-time observation of phase transition from layered to spinel phase under electron beam irradiation J Anal Sci Technol (IF 2.4) Pub Date : 2023-07-21 Jong Hyeok Seo, Joon Yong Park, Yong-Il Kim, Ki Min Nam, Jae Hyuck Jang, Ji-Hwan Kwon
Transition metal hydroxides (TM(OH)2) have drawn significant attention for their potential applications in the environmental and energy field. In this study, we investigated the phase transition of cobalt hydroxide (Co(OH)2) under electron beam irradiation using in situ high-resolution transmission electron microscopy. Both the α- and β-Co(OH)2 phases underwent a phase transition to a spinel Co3O4
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Impedance and voltammetry detection of bromate in food samples using NiPcMWCNTs modified glassy carbon electrode J Anal Sci Technol (IF 2.4) Pub Date : 2023-07-20 Sheriff Aweda Balogun, Omolola Esther Fayemi
A sensitive bromate sensor was developed using nickel phthalocyanine multi-walled carbon nanotubes nanocomposite modified on a glassy carbon electrode. The NiPcMWCNTs nanocomposite was prepared from nickel nanoparticles, phthalocyanine, and functionalized MWCNTs via ultrasonication. UV–visible spectroscopy, SEM, XRD, TEM, and EDX techniques were used to verify the successful fabrication of the nanomaterials
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Graphene quantum dot nanocomposites: electroanalytical and optical sensor technology perspective J Anal Sci Technol (IF 2.4) Pub Date : 2023-07-04 Muhammad Shalahuddin Al Ja’farawy, Dinakaran Thirumalai, Jaewon Lee, Ho Sang Jung, Seung-Cheol Chang, Jang-Hee Yoon, Dong-Ho Kim
Electroanalytical and optical techniques are widely used in the development of nanomaterials-based sensor platforms. These techniques have a quick response, high sensitivity, and selectivity. Electroanalytical and optical techniques are widely used in the development of nanomaterial-based sensor platforms. These sensors must be able to detect biomarkers, pathogens, toxins, and pharmaceuticals in biological
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Magnetic chitosan-zeolite composite as an adsorbent in ultrasound-assisted magnetic solid phase extraction of tetracyclines in water samples J Anal Sci Technol (IF 2.4) Pub Date : 2023-07-04 Mpho Charmaine Lefatle, Lawrence Mzukisi Madikizela, Vusumzi Emmanuel Pakade, Philiswa Nosizo Nomngongo
An ultrasound-assisted magnetic solid-phase extraction method was developed to pre-concentrate tetracyclines (TCs) in wastewater and river water. The magnetic chitosan-zeolite composite was used as an adsorbent. The morphological and structural properties of the adsorbent were characterised by various analytical techniques. The factors affecting the ultrasound-assisted magnetic solid-phase extraction
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Mass spectrometry-based metabolomics study for delay tomato fruit ripening by sound waves J Anal Sci Technol (IF 2.4) Pub Date : 2023-07-04 Mi-Jeong Jeong, Byoung Joon Ko, Joo Yeol Kim
Tomato (Solanum lycopersicum L.) is one of the most consumed vegetables worldwide. The ripening of tomato is performed for its freshness and represented by color and gene expression. In our previous study, we performed molecular analyses on tomato ripening with and without sound-wave treatment. In the present study, we performed metabolomics analysis of ripening tomatoes with and without sound-wave
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Nano-fluorescent quantum dots as substrates for determination of ribavirin in pharmaceuticals and human plasma as well as monitoring of its kinetic interaction with salmon sperm DNA J Anal Sci Technol (IF 2.4) Pub Date : 2023-06-29 Ahmed Faried Abdel Hakiem, John M. Boushra, Deena A. M. Noureldeen, Adel S. Lashien, Tamer Z. Attia
Ribavirin (RIB) was successfully determined by fluorescence spectroscopy upon its quenching to environment friendly phosphorus and nitrogen co-doped carbon quantum dots (PNQDs). Different analytical parameters affecting the fluorescence spectra have been optimized and validated in accordance to the ICH guidelines. The proposed method has provided an efficient tracing of the interaction between RIB
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Double hairpin-assembled probe-mediating catalytic hairpin assembly and primer exchange reaction for sensitive and label-free miRNA analysis in gastric carcinoma J Anal Sci Technol (IF 2.4) Pub Date : 2023-06-21 Hongyu Zhou, Tiantian Liu, Jing Wang, Mingliang Liu, Yaoyao Lei, Xiaohua Tan, Ruhua Wang, Xijin Luo, Yeqing Chen
The aberrant expression of microRNA (miRNA) is closely associated with various pathological processes, such as the development of gastric cancer. High-efficiency quantification of miRNAs is significant for the diagnosis, prognosis, and treatment of cancers. However, the sensitive and reliable detection of miRNA remains a huge challenge. We depict here a novel fluorescent approach for sensitive and
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A novel cysteine catalytic oxidation-based colorimetric approach for sensitive analysis of acute pancreatitis-related microRNA J Anal Sci Technol (IF 2.4) Pub Date : 2023-06-19 Mingwei Gong, Guoyan Jiang, Yuan Rong, Zeping Yang, Dong She, Chunhong Sun
It is essential to establish simple, sensitive and accurate quantitative approaches for microRNAs (miRNAs) identification due to its crucial roles in a variety of physiological and pathological processes. Herein, we propose a novel RCA-based colorimetric method for sensitive and reliable miRNA analysis. In this approach, cyclization of the padlock sequence by miRNA-21 initiates the RCA to produce numerous
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ALS-linked FUS R521C disrupts arginine methylation of UBAP2L and stress granule dynamics J Anal Sci Technol (IF 2.4) Pub Date : 2023-05-31 Mi-Hee Jun, Sang-Hee Lee, Yang Hoon Huh
Mutations in the fused-in-sarcoma (FUS) gene have been linked to familial amyotrophic lateral sclerosis (fALS). FUS aggregates in the cytosol and associates with stress granules (SGs) in pathological cases, whereas FUS is normally found in the nucleus. However, little is known about how FUS mutations cause neurodegeneration in ALS, which is distinguished by FUS-positive inclusion and stress granules
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A simple and rapid extraction of lipids in plasma using spin column with superabsorbent polymer beads for mass spectrometry J Anal Sci Technol (IF 2.4) Pub Date : 2023-05-25 Jung Hoon Choi, Geul Bang, Jeong Ah Kim, Young Hwan Kim
The efficient extraction of lipid species in plasma was developed for quick sample preparation and accurate lipid analysis, using spin column with superabsorbent polymer beads (SAP), as the improvement of previous SAP method reported before. The modified SAP (mSAP) method is composed of simple steps, including sample loading, swelling, solvent addition, centrifugation, and drying of the resulting lipid
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Sulfur reduction distillation of sulfides and verification of the effect of sulfur isotopic fractionation during pretreatment J Anal Sci Technol (IF 2.4) Pub Date : 2023-05-09 Jaeguk Jo, Toshiro Yamanaka, Hitoshi Chiba, Dongbok Shin
Toxic gases can be emitted when sulfides form compounds with heavy metals; thus, a series of pretreatments are required prior to the analysis of sulfur isotope ratios to remove unnecessary elements. In addition, it is necessary to verify the effect of sulfur isotope fractionation caused by the plurality of sulfides comprising different sulfide species during the pretreatment process. In this study
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DSN enzyme recognition initiated rolling circle amplification (DiRCA) for accurate miRNA detection in immune response and immune repair after trauma J Anal Sci Technol (IF 2.4) Pub Date : 2023-04-17 Yi Mei, Jun Zhang, Li Zhu, Tianjiao Li, Hong Zhou, Mingjia Xie, Dongmei Zeng, Yajun Gou
Recent studies have reported that miRNA plays an important role in immune response and immune repair after trauma. By regulating the expression of related target genes, miRNA regulates the production, proliferation, development and immune response of immune cells. Therefore, it is in urgent demand to develop an novel method for miRNA analysis. Rolling circle amplification (RCA), as an attractive isothermal
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Pharmacokinetics and brain distribution of the therapeutic peptide liraglutide by a novel LC–MS/MS analysis J Anal Sci Technol (IF 2.4) Pub Date : 2023-03-20 Hyeon Seok Oh, Minkyu Choi, Tae Suk Lee, Yejin An, Eun Ji Park, Tae Hwan Kim, Soyoung Shin, Beom Soo Shin
Liraglutide is a glucagon-like peptide-1 (GLP-1) analog that has been utilized for the treatment of type 2 diabetes mellitus. Liraglutide at a higher dose also shows beneficial effects in weight loss, which prompted its widespread use as an anti-obesity drug. The potential of liraglutide to treat Alzheimer’s disease and cognitive impairment has also been suggested. Nevertheless, the pharmacokinetics
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Development and validation of a sensitive assay for the quantification of arachidonoylcyclopropylamide (ACPA) in cell culture by LC–MS/MS J Anal Sci Technol (IF 2.4) Pub Date : 2023-03-07 Özge Boyacıoğlu, Tuba Reçber, Sedef Kır, Petek Korkusuz, Emirhan Nemutlu
Synthetic and natural cannabinoid derivatives are highly investigated as drug candidates due to their antinociceptive, antiepileptic and anticancer potential. Arachidonoylcyclopropylamide (ACPA) is a synthetic cannabinoid with antiproliferative and apoptotic effects on non-small cell lung cancer and pancreatic and endometrial carcinoma. Thus, ACPA has a great potential for being used as an anticancer
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Benefits of high-dielectric pad for neuroimaging study in 7-Tesla MRI J Anal Sci Technol (IF 2.4) Pub Date : 2023-03-06 Shin-Eui Park, Yeong-Jae Jeon, Hyeon-Man Baek
This study aimed to evaluate whether the use of a high-dielectric pad is effective in increasing transmit and receive sensitivity in areas of low signal intensity in the human brain at high magnetic fields and assess its usefulness in neuroimaging studies. The novelty of this study lies in the first reported use of diffusion tensor imaging (DTI) results to evaluate the effect of the pad on neuroimaging
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Highly fluorescent hydroxyl groups functionalized graphitic carbon nitride for ultrasensitive and selective determination of mercury ions in water and fish samples J Anal Sci Technol (IF 2.4) Pub Date : 2023-03-01 Y. G. Abou El-Reash, Eslam A. Ghaith, Osama El-Awady, Faisal K. Algethami, Haiqing Lin, Ehab A. Abdelrahman, Fathi S. Awad
Heavy metal ion pollution is always a serious problem worldwide. Therefore, monitoring heavy metal ions in environmental water is a crucial and difficult step to ensure the safety of people and the environment. A mercury ion (Hg2+) fluorescence probe with excellent sensitivity and selectivity is described here. The functionalized graphitic carbon nitride nanosheets (T/G-C3N4) fluorescence probe was
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In silico toxicity assessment and trace level quantification of two genotoxic impurities in silodosin using capillary gas chromatography J Anal Sci Technol (IF 2.4) Pub Date : 2023-02-24 Ravi Kiran Panchakarla, Punna Rao Ravi, Manidhar Syam Kumar Buddha, Sumanth Mullangi, Venkata Gowri Chandra Sekhar Kondapalli
A capillary gas chromatographic method using flame ionization detection was developed and validated for the trace quantification of 2-bromoethanol (2-BE) and 2-bromoethylmethanesulfonate (2-BEM) in silodosin, used in the treatment of benign prostatic hyperplasia. Chromatographic separation was performed in spilt mode using nitrogen as carrier gas on a column containing crosslinked polyethylene glycol
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UHPLC‐Q‐TOF‐MS/MS‐guided dereplication to study chemical constituents of Hedera nepalensis leaves in northern Vietnam J Anal Sci Technol (IF 2.4) Pub Date : 2023-02-24 Pham Hong Ngoc, Tran Chieu An, Nguyen Tuan Hiep, Tran Phan Huynh Nhu, Le Ngoc Hung, Nguyen Quang Trung, Bui Quang Minh, Phung Van Trung
Hedera nepalensis is commonly used as a traditional medicine for the treatment of several diseases. In this research, the efficient characterization of chemical constituents, especially triterpenoid saponins, contained in H. nepalensis extract was established by applying ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry method (UHPLC‐Q‐TOF‐MS/MS). As a
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Advances and key considerations of liquid chromatography–mass spectrometry for porcine authentication in halal analysis J Anal Sci Technol (IF 2.4) Pub Date : 2023-02-20 Kifayati Rosiyanti Dewi, Maya Ismayati, Nissa Nurfajrin Solihat, Nancy Dewi Yuliana, Feri Kusnandar, Handy Riantana, Heryani Heryani, Abdul Halim, Thamina Acter, Nizam Uddin, Sunghwan Kim
The halal food industries are rapidly expanding to fulfill global halal demands. Non-halal substances such as porcine proteins are often added intentionally or unintentionally to products. The development of highly selective and sensitive analytical tools is necessary, and liquid chromatography–mass spectrometry is a powerful tool that can cope with the challenge. The LC–MS method has great potential
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Controlled release of harmful pesticide dichlorvos through synthesized biodegradable aloe vera–acrylic acid-based hydrogel and its utilization in soil water management J Anal Sci Technol (IF 2.4) Pub Date : 2023-02-17 Saruchi, Vaneet Kumar, Ayman A. Ghfar, Sadanand Pandey
The present work deals with the synthesis of biodegradable hydrogel of a natural polysaccharide aloe vera and vinyl monomer acrylic acid. In this synthesis, ammonium persulfate–glutaraldehyde was used as initiator-cross-linker system, acrylic acid as monomer and aloe vera as backbone. Grafting was confirmed by different techniques like SEM, FT-IR, XRD and EDS. Maximum percentage swelling of synthesized
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Proteome network analysis of skeletal muscle in lignan-enriched nutmeg extract-fed aged mice J Anal Sci Technol (IF 2.4) Pub Date : 2023-02-16 Je-Ho Lee, Hyuno Kang, Gyung-Tae Ban, Beom Kyu Kim, JaeHyeon Lee, Heeyoun Hwang, Hwa-Seung Yoo, Kun Cho, Jong-Soon Choi
Sarcopenia, characterized by reduced muscle mass and fiber number leading to muscular atrophy, has been associated with serious socioeconomic challenges among the elderly in developed countries. Therefore, preventing sarcopenia could be a promising strategy for achieving a healthy aging society. Nutmeg (Myristica fragrans) has been used as a spice to increase flavor and prevent putrefaction of food
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Electrochemical study of agarose hydrogels for natural convection on macroelectrodes and ultramicroelectrodes J Anal Sci Technol (IF 2.4) Pub Date : 2023-02-08 Jihun Han, Sukman Jang, Byung-Kwon Kim, Kyungsoon Park
Electrochemical measurements using an agarose hydrogel as a solid electrolyte and ferrocyanide as a redox probe were conducted to analyze transport properties and natural convection effects. The mass transport properties and diffusion coefficients of ferrocyanide were studied using various macroelectrodes and ultramicroelectrodes via cyclic voltammetry. The experimental results confirmed that the mass
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Electroanalytical biosensor based on GOx/FCA/PEG-modified SWCNT electrode for determination of glucose J Anal Sci Technol (IF 2.4) Pub Date : 2023-02-07 Do Kyoung Han, Cheng Ai Li, Sung Ho Song, Kun Cho, Jong-Soon Choi, Seong Eun Son, Gi Hun Seong
This paper describes a simple electrochemical sensing platform based on single-walled carbon nanotube (SWCNT) electrodes for glucose detection. The device fabrication using O2-plasma treatment allows precision and uniformity for the construction of three SWCNT electrodes on the flexible plastic substrate. Glucose assay can be simply accomplished by introducing a glucose sample into the fabricated biosensor
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Quantification of venadaparib, a novel PARP inhibitor, in the rat and dog plasma using liquid chromatography/tandem mass spectrometry J Anal Sci Technol (IF 2.4) Pub Date : 2023-02-01 Myongjae Lee, Eunhye Jang, Jungwoo Lee, SungKu Choi, Won Sik Lee, Nam Seok Baek, Sungsook Lee, Young-Whan Park, Jong-Hwa Lee, Suk-Jae Chung
Venadaparib (VEN), a next-generation inhibitor of poly (ADP-ribose) polymerases, is under development for oral use in patients having cancers with deoxyribonucleic acid repair defects. The objective of this study was to develop and validate a sensitive and robust analytical method for quantifying VEN in a small volume of plasma samples from rats and dogs, and to assess the feasibility of the assay
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Inactivation of mammalian spermatozoa on the exposure of TiO2 nanorods deposited with noble metals J Anal Sci Technol (IF 2.4) Pub Date : 2023-01-26 Young-Joo Yi, Love Kumar Dhandole, Dong-Won Seo, Sang-Myeong Lee, Jum Suk Jang
Titanium dioxide (TiO2) nanorods (NRs) are well-known semiconducting and catalytic material that has been widely applied, but their toxicities have also attracted recent interest. In this study, we investigated and compared the toxic effects of TiO2 NRs and TiO2 NRs loaded with Ag or Au NPs on boar spermatozoa. As a result, sperm incubated with Ag-TiO2 NRs showed lower motility than sperm incubated
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Dual signal amplification coupling with DNA-templated silver nanoclusters for sensitive and label-free detection of thrombin J Anal Sci Technol (IF 2.4) Pub Date : 2023-01-26 Baojun Zhang, Weiwei Ma, Jun Guo, Qiufeng Zhao, Chuangchuang Zhang, Shilong Zhu, Haibo Xu, Yanyan Yin
Sensitive and reliable determination of thrombin is relevant in the realms of medical and biological research as it serves as an essential biomarker of a number of blood-related illnesses. Herein, we integrate allosteric probe-based specific identification of thrombin and dual signal amplification to present an unique fluorescent technique for label-free and sensitive thrombin detection. Based on DNA
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Ultrasensitive and colorimetric small extracellular vesicles (sEVs) analysis via dual-cycle signal tool J Anal Sci Technol (IF 2.4) Pub Date : 2023-01-23 Linhong Ning, Yuan Zhou, Yang Xie, Zhixiong Duan, Feng Yu, Heng Cheng
For the clinical diagnosis of diseases and for basic biological research, it is crucial to develop a trustworthy and efficient method for detecting small extracellular vesicles (sEVs) in multiple experimental conditions. Here, we create a colorimetric assay that enables sensitive and precise sEVs identification without the need for pricey equipment. In this assay, the exonuclease III (Exo III)-assisted
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Development of a certified reference material for the analysis of vitamins in multivitamin tablets J Anal Sci Technol (IF 2.4) Pub Date : 2023-01-18 Lee, Joonhee, Kim, Byungjoo, Sim, Hee-Jung, Seo, Dongwon, Kwak, Byung-Man, Won, Jongeun, Lee, Sunyoung, Baek, Song-Yee, Han, Jeesoo
Multivitamin tablet certified reference material (CRM, 108-10-019) was developed for the analysis of seven water-soluble vitamins, including thiamine, riboflavin, nicotinamide, pantothenic acid, pyridoxine, biotin, and folic acid. The CRM was prepared in powder form by grinding multivitamin tablets and then mixing, sieving, and bottling the powder. For the certification of each water-soluble vitamin
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Exploring the performance of magnetic methacrylic acid-functionalized β-cyclodextrin adsorbent toward selected phenolic compounds J Anal Sci Technol (IF 2.4) Pub Date : 2023-01-13 Mamman, S., Yaacob, S. F. F. S., Raoov, M., Mehamod, F. S., Zain, N. N. M., Suah, F. B. M.
In this study, the removal of bisphenol A (BPA), 2,4-dinitrophenol (2,4-DNP), and 2,4-dichlorophenol (2,4-DCP) using a new magnetic adsorbent methacrylic acid-functionalized β-cyclodextrin (Fe3O4@MAA-βCD) was evaluated. The materials were characterized by Fourier transform infrared spectroscopy, scanning electron microscope, transmission electron microscopy, and X-ray diffraction. The batch adsorption
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The role of molecular oxygen (O2) and UV light in the anion radical formation and stability of TCNQ and its fluorinated derivatives J Anal Sci Technol (IF 2.4) Pub Date : 2023-01-09 Bang, Jieun, Park, JaeHong
We report the electronic absorption spectroscopy of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and its fluorinated derivatives (F2TCNQ and F4TCNQ), well-known electron-accepting molecules in common organic solvents (toluene, chlorobenzene, acetonitrile, and ethanol) under controlled exposure to air (O2) and UV light. All compounds (FxTCNQ (x = 0, 2, 4)) were stable in a neutral state (FxTCNQ0) in toluene