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Real-world Evidence of the Herb-drug Interactions J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Hsueh-Yi Pan, Li-Wei Wu, Pin-Chun Wang, Ping-Hung Chiu, Meng-Ting Wang
Herbal medicine (HM) is a type of medicine that uses active ingredients made from plants to treat diseases and maintain health and wellbeing. Due to its increasing worldwide usage, the possibility of HMs and conventional drugs being concurrently used is high, potentially leading to adverse events resulting from herb-drug interactions. Despite the safety concerns regarding such interactions, few studies
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Metabolism-involved drug interactions with traditional Chinese medicines in cardiovascular diseases J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Ren-Jong Liang, Shu-Hao Hsu, Tien-Yu Chang, Tzu-Yi Chiang, Hong-Jaan Wang, Yune-Fang Ueng
Herbal medicines have been widely used for the past millennia. Traditional Chinese medicine (TCM) is a major modality in Chinese medical care and has garnered global attention owing to its pharmacological effects and multi-targeted actions. The increased incidence of sequential or concurrent use of herbs and drugs in patients forces us to consider herb–drug interactions (HDIs) in this modern era. One
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Bromelain activates the AMP-activated protein kinase-autophagy pathway to alleviate hepatic lipid accumulation J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Po-An Hu, Man-Chen Hsu, Szu-Han Chen, Chia-Hui Chen, Yu Ru Kou, Jenq-Wen Huang, Tzong-Shyuan Lee
Bromelain, a cysteine protease found in pineapple, is known to exert protective effects against non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanism is unclear. In this study, we aimed to investigate the molecular mechanisms underlying the beneficial effects of bromelain using in vivo and in vitro models. C57BL/6 mice were fed a high-fat diet (HFD) with or without bromelain
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Fluorescence detection of malachite green in fish based on aptamer and SYBR Green I J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Jia Wang, Chengyi Hong, Zhengzhong Lin, Zhi-Yong Huang
A simple fluorescence method to quantitatively monitor malachite green (MG) was introduced based on the conformation switch effect of MG-aptamer (Apt) and the fluorochrome of SYBR Green I (SGI). SGI can embed in the stem-loop structure of Apt to produce fluorescence. However, the fluorescence will be quenched when MG is introduced because of the specific binding of Apt to MG. Under the optimal conditions
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Quantification of anthocyanosides in grapes by QuEChERS and biphenyl-UHPLC tandem mass spectrometry J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Lun-Chi Yang, Sung-Fang Chen
In this study, the QuEChERS and UHPLC-MS/MS method using a biphenyl stationary phase was developed and applied for the rapid separation of 12 anthocyanosides in grapes. Efficient separation was achieved for a wide range of mono- and un-glycosylated anthocyanosides. The linear ranges of the target anthocyanosides were 0.5–500 ng mL−1. The intra- and inter-day precisions were both below 11.8%. Anthocyanosides
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Exploring the relationship between metabolite composition and the cold/hot properties ascribed in traditional Chinese medicine by mass spectral molecular networking – A pilot study J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Chun-Han Su, Yu-Chieh Cheng, Kuei-Hung Lai, Yu-Chia Chang, Chi-Hui Sun, Po-Wen Tu, Ching-Chih Lin, Tsong-Long Hwang, Yu-Liang Yang
Traditional Chinese medicine (TCM) has been applied to improve human health for millennia. In the TCM system, “medicinal property” (yao xing; hot and cold properties) is a core concept used to describe the influences of medicinal materials on human physiological conditions, and metabolites are believed to be one of the major ingredients of TCMs that affect their medicinal property. However, due to
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Systems pharmacology dissection of the mechanisms and therapeutic potential of Cassiae semen for hepatoprotection and brightening eyes J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Jing-Xiao Zhang, Zi-Yi Chen, Xue-Zhen Huang, Lin-Yue Qi, Wei Zhou
Cassiae semen has been shown to play significant roles in reversing “liver fire” to improve vision. The systems mechanism of Cassiae semen for hepatoprotection and brightening eyes has not been fully explored. The systems pharmacology approach is proposed to dissect the potential pharmacological mechanism of Cassiae semen for hepatoprotection and brightening eyes. The results showed that 26 active
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Phytochemical characterization, antioxidant potential, and health risk assessment of Radix Oryzae Glutinosae J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Hai-Ping Liu, Jian-Feng Tang, Kai Ren, Tong-Jun Chen, Ping-Ping Zhu, Dong-Dong Sun, Wei-Yun Wang
Radix Oryzae Glutinosae (ROG) has been used as a traditional anhidrotic agent in China. Ten samples were systematically assessed based on four aspects of their chemical profiles and antioxidant activity. The former was achieved using ultraviolet-visible spectra (UV), infrared absorption spectra (IR), proton nuclear magnetic resonance spectroscopy (1H NMR), and inductively coupled plasma-mass spectrometry
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Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference⋆ J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai, Fang-Rong Chang
The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p-coumaroyl-CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents
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Stress amelioration and anti-inflammatory potential of Shiikuwasha (Citrus depressa Hayata) essential oil, limonene, and γ-terpinene J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Yonathan Asikin, Kuniyoshi Shimizu, Hironori Iwasaki, Hirosuke Oku, Koji Wada
Shiikuwasha (Citrus depressa Hayata) essential oil (SEO) extracted from Shiikuwasha fruit pulp contains two major volatile components, limonene and γ-terpinene (56.56–57.31 and 24.41–24.98%, respectively). In this study, we showed that the aroma streams of SEO, limonene, and γ-terpinene exhibited significant physiological stress amelioration effects in nine healthy female panelists tested in a 30-min
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Melatonin exerts anti-fibrinolytic effects by regulating IL-1β-induced changes in uPA, uPAR, and PAI-1 expression/production in human dental pulp cells J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Mei-Chi Chang, Bor-Hao Zhong, Hui-Na Lee, Fu-Hsiung Chuang, Ming-Shu Lee, Hsiao-Hua Chang, Yu-Hwa Pan, Jiiang-Huei Jeng
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine and its expression is increased in inflamed dental pulp. IL-1β affects plasminogen activation system molecules, which are crucial for tissue inflammation, fibrinolysis, matrix turnover, and cell adhesion and migration. Melatonin, which provides circadian and seasonal signals, is a physiological endocrine generated by the pineal gland. It has anti-oxidant
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Diallyl disulfide inhibits proliferation, epithelial–mesenchymal transition, and invasion through RORα-mediated downregulation of Wnt1/β-catenin pathway in gastric cancer cells J. Food Drug Anal. (IF 3.6) Pub Date : 2023-07-10 Jian Su, Hui He, Yu-Kun Li, Hong Xia, Fang Liu, Ying Zeng, Xi Zeng, Hui Ling, Bo Su, Qi Su
Overactivation of Wnt/β-catenin pathway due to dysfunction of retinoid-related orphan receptor α (RORα) is related to cancer development and progression. Diallyl disulfide (DADS), an active component of garlic, has been reported in our previous study for upregulation of RORα expression in gastric cancer (GC) cells. It remains to be elucidated the role and mechanism of RORα in DADS against GC. This
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Preparation procedures of food and beverage samples for oxygen bomb calorimetry: A scoping review and reporting checklist. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Zane Hopper,Ben Desbrow,Shelley Roberts,Chris Irwin
Standardised bomb calorimetry methods are essential to accurately quantify the gross energy within food and beverages, yet no accepted protocols exist. The objective of this review was to synthesise literature on food and beverage sample preparation methods used for conducting bomb calorimetry. This synthesis enhances our understanding of the extent to which methodological variances may currently affect
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Selective detection of tricyclazole by optical technique using thiomalic acid-modified Au and Ag nanoparticle mixtures. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Yu-Shu Pan,Tsunghsueh Wu,Cho-Chun Hu,Tai-Chia Chiu,Chen-Hao Yeh,Yang-Wei Lin
This study proposes the use of thiomalic acid-modified Au and Ag nanoparticle mixtures (TMA-Au/AgNP mixes) for the selective detection of tricyclazole. Upon the addition of tricyclazole, the color of TMA-Au/AgNP mixes solution changes from orange-red to lavender (red-shift). According to the density-functional theory calculations, tricyclazole-induced aggregation of TMA-Au/AgNP mixes through electron
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What nature has to offer: Opportunities for immuno-oncology. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Rubina Kousar,Cheng-Han Lin,Bbumba Patrick,Miao He,Dong-Chuan Wu,Xing-Guo Li
Recent rapid development of cancer therapy has come about with the paradigm shift from the traditional goal of targeting cancer cells themselves, to reprograming the immune tumor microenvironment. Accumulating evidence shows that compounds that target epigenetic regulation, called epidrugs, play a crucial role in mediating the immunogenicity of cancer cells and in reshaping antitumor immunity. A large
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Chemometrics-assisted spectroscopic methods for rapid analysis of combined anti-malarial tablets. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Panawan Pruksapha,Putthiporn Khongkaew,Chaweewan Suwanvecho,Nantana Nuchtavorn,Chutima Phechkrajang,Leena Suntornsuk
Combination of piperaquine (PQ) (320mg) and dihydroartemisinin (DHA) (40 mg) is an anti-malarial formulation, which is recommended by World Health Organization (WHO). Simultaneous analysis of PQ and DHA can be problematic due to the lack of chromophores or fluorophores in DHA molecule. Whereas PQ possesses strong UV absorption and it presents in 8 times of DHA contents in the formulation. In this study
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Electrochemically synthesized green fluorescent carbon dots for quantitation of hypochlorite and carbendazim. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Kuan-Min Lo,Yu-Shen Lin,Je-Wen Liou,Tai-Chia Chiu,Cho-Chun Hu
Green emission carbon dots (CDs) electrochemically prepared from 2,6-pyridinedicarboxylic acid and o-phenyl-enediamine were applied separately for the quantitation of hypochlorite and carbendazim. The characteristic and optical properties of the CDs were studied through fluorescence, UV-vis absorption, X-ray photoelectron spectroscopy, and transmission electron microscopy. The synthesized CDs were
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Using lanthanide ions as magnetic and sensing probes for the detection of tetracycline from complex samples. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Yan-Cen Zhan,Chin-Poa Chiu,Yu-Chie Chen
Tetracycline (TC) is a broad-spectrum antibiotic and has been added to animal feeds to grow livestock under healthy conditions, making it important to have effective methods for rapidly detecting TC in complex samples. In this study, a novel method that uses lanthanide ions (i.e. Eu3+ and Gd3+) as magnetic and sensing probes for the detection of TC from aqueous samples is explored. When dissolving
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Three-dimensional strategies in the quantitative resolution of kinetic UV absorbance measurements for monitoring the oxidation of quercetin by oxidant agents and analyzing dietary supplement product. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Erdal Dinç,Asiye Üçer,Nazangül Ünal
Three-dimensional strategies involving the application of parallel factor analysis (PARAFAC) to the kinetic UV absorbance measurements were elaborated to monitor the oxidation of quercetin with oxidant agents (K2Cr2O7 and KIO3) and to quantify analyte in a dietary supplement product. Loadings (spectral, kinetic and concentration profiles) were obtained by the PARAFAC deconvolution. Spectral identification
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Development of a lateral flow immunoassays-based method for the screening of ractopamine in foods and evaluation of the optimal strategy in combination of screening and confirmatory tests. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Yuan-Chih Chen,Jen-Yi Hsu,Chien-Sheng Chen,Yi-Ting Chen,Pao-Chi Liao
Ractopamine has been authorized as a feed additive and permitted in animal husbandry. With the establishment of the regulation to limit the concentration of ractopamine, a rapid screening method for ractopamine is urgently needed. Additionally, how to combine the screening and confirmatory tests of ractopamine is also critical to maximizing the efficiency of testing. Here, we developed a lateral flow
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Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Tinglin Song,Jiaye Chen,Sizhu Yang,Boqun Liu,Lingling Zhang,Qian Zhang,Jung-Chien Cheng,Lanlan Fang
Steroidogenic acute regulatory protein (StAR) plays a critical role in the regulation of progesterone (P4) production. Resveratrol (RSV), a natural polyphenol, has beneficial effects on reproductive function. However, its effects on StAR expression and P4 production in human granulosa cells remain undetermined. In this study, we showed that treatment of RSV upregulated StAR expression in human granulosa
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Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Huang-Ju Tu,Chih-Jou Su,Chao-Shiang Peng,Tony Eight Lin,Wei-Chun HuangFu,Kai-Cheng Hsu,Tsong-Long Hwang,Shiow-Lin Pan
Alzheimer's disease (AD) is a devastating neurodegenerative disease with more than 50 million people suffer from it. Unfortunately, none of the currently available drugs is able to improve cognitive impairment in AD patients. Urolithin A (UA) is a metabolite obtained from ellagic acid and ellagitannin through the intestinal flora, and it has antioxidant and anti-inflammatory properties. Previous reports
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Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Chun Woong Park,Ki-Bae Hong,Hyung Joo Suh,Yejin Ahn
Ashwagandha (Withania somnifera L. Dunal), an Indian medicinal plant that has been used for centuries to treat insomnia, exhibits a variety of biological activities, such as improving cognitive function, immunity and anxiety. In this study, the effect of enzyme-treated Ashwagandha root extract (EA) and on sleep was evaluated using rodent models. Starch contained in the Ashwagandha root extract was
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The inhibitory effect of quercetin-3-glucuronide on pulmonary injury in vitro and in vivo. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-06-15 Pei-Rong Yu,Jen-Ying Hsu,Chiao-Yun Tseng,Jing-Hsien Chen,Hui-Hsuan Lin
Pulmonary injury is defined as a progressive inflammation. Extensive pro-inflammatory cytokines are secreted from alveolus, associated with the production of reactive oxygen species (ROS) and apoptosis. The model of endotoxin lipopolysaccharide (LPS)-stimulated lung cells has been applied to mimic the pulmonary injury. Some antioxidants and anti-inflammatory compounds can be used as chemopreventive
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Simultaneous determination of 24 congeners of 2- and 3-monochloropropanediol esters and 7 congeners of glycidyl esters using direct multi-residue analytical LC-MS/MS methods in various food matrices. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Ching-Chang Lee,Bo-Lun Lin,Yi-Wen Huang,Ning-Syuan Hsu,Wei-Hsiang Chang
Glycidyl esters (GEs) and 2- and 3-monochloropropanediol esters (MCPDEs) are emerging process-generated food contaminants known as possible carcinogens. Herein, a direct method is developed and validated for the first time to simultaneously quantify seven GEs and twenty-four MCPDE congeners of processed foods using liquid chromatography-tandem mass spectrometry in a single sequence without ester cleavage
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Untargeted metabolomics analysis assisted by signal selection for comprehensively identifying metabolites of new psychoactive substances: 4-MeO-α-PVP as an example. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Hsin-Yi Wu,Yuan-Chih Chen,Jing-Fang Hsu,Hsiang-Ting Lu,Yu-Yi Pan,Mi-Chia Ma,Pao-Chi Liao
New psychoactive substances (NPS) have been rapidly emerged as legal alternatives to controlled drugs, which raised severe public health issue. The detection and monitoring of its intake by complete metabolic profiling is an urgent and vital task. Untargeted metabolomics approach has been applied for several NPS metabolites studies. Although the number of such works is relatively limited but with a
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Development of a metabolomics-based data analysis approach for identifying drug metabolites based on high-resolution mass spectrometry. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Hsiao-Hsien Ting,Yi-Shiou Chiou,Tien-Yi Chang,Guan-Yu Lin,Pei-Jhen Li,Chia-Lung Shih
A metabolomics-based approach to data analysis is required for drug metabolites to be identified quickly. This study developed such an approach based on high-resolution mass spectrometry. Our approach is a two-stage one that combines a time-course experiment with stable isotope tracing. Pioglitazone (PIO) was used to improve glycemic management for type 2 diabetes mellitus. Consequently, PIO was taken
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Investigation of monacolin K, yellow pigments, and citrinin production capabilities of Monascus purpureus and Monascus ruber (Monascus pilosus). J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Tzu-Shing Lin,Shih-Hau Chiu,Chien-Chi Chen,Chih-Hui Lin
Red mold rice (RMR) is a traditional Chinese medicine prepared using Monascus fermentation. Monascus ruber ( pilosus) and Monascus purpureus have a long history of use as food and medicine. As an economically important starter culture, the relationship between the taxonomy of Monascus and production capabilities of secondary metabolites is crucial for the Monascus food industry. In this study, monacolin
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High-resolution 1H NMR analysis of continuous and discontinuous thermo-oxidative susceptibility of culinary oils during frying at 180 °C. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Gilbert Ampem,Adam Le Gresley,Martin Grootveld,Declan P Naughton
Lipid oxidations products (LOPs) are reactive mutagenic and carcinogenic species known to be generated in thermally stressed culinary oils. Mapping the evolution of LOPs in culinary oils exposed to standard frying practices - both continuous and discontinuous thermo-oxidation - at 180 °C is vital to our understanding of these processes, and to the development of scientific solutions for their effective
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Polyvinylpyrrolidone-passivated fluorescent iron oxide quantum dots for turn-off detection of tetracycline in biological fluids. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Sri Sudewi,Lutfi Chabib,Muhammad Zulfajri,Gangaraju Gedda,Genin G Huang
Tetracycline is an antibiotic that has been prescribed for COVID-19 treatment, raising concerns about antibiotic resistance after long-term use. This study reported fluorescent polyvinylpyrrolidone-passivated iron oxide quantum dots (IO QDs) for detecting tetracycline in biological fluids for the first time. The as-prepared IO QDs have an average size of 2.84 nm and exist a good stability under different
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Guilu Erxian Jiao enhances protein synthesis, glucose homeostasis, mitochondrial biogenesis and slow-twitch fibers in the skeletal muscle. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Wei-Yu Fang,Wan-Hsuan Chang,Yi-Hong Tsai,Hung-Te Hsu,Fang-Rong Chang,Chih-Lung Lin,Yi-Ching Lo
Guilu Erxian Jiao (GEJ) is a commonly used nutritional supplement due to its rich content of amino acids. It is also a traditional herbal medicine for improving degenerative joint. This study aimed to investigate the effect and mechanism of GEJ water extract (GEJ-WE) on skeletal muscle in C2C12 myotubes and C57BL/6J mice. Analysis of GEJ-WE were performed by high-performance liquid chromatography fingerprinting
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Regulatory considerations for generic products of non-biological complex drugs. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Yu-Hsuan Liu,Yi-Shuo Chen,Ting Tseng,Min-Lin Jiang,Churn-Shiouh Gau,Lin-Chau Chang
The Non-Biological Complex Drug (NBCD) Working Group defines an NBCD as "a medicinal product, not being a biological medicine, where the active substance is not a homo-molecular structure, but consists of different (closely related and often nanoparticulate) structures that cannot be isolated and fully quantitated, characterized and/or described by physicochemical analytical means". There are concerns
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Determination of 24 sulfonamide antibiotics in instant pastries by modified QuEChERS coupled with ultra performance liquid chromatography-tandem mass spectrometry. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Shuo Li,Can Zhang,Hui-Xin Tang,Yue Gu,Ai-Jing Guo,Ke Wang,Kao-Qi Lian
There were few reports about antibiotic residues in egg-containing products. In the study, an effective method for the simultaneous determination of 24 sulfonamide antibiotics in two instant pastries based on a modified QuEChERS sample preparation technique coupled with ultra performance liquid chromatography-tandem mass spectrometry was developed. The results show that the average recoveries of the
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Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Chun-Yu Lin,Yi-Ju Chen,Chih-Hsuan Hsu,Yu-Hsuan Lin,Peng-Tzu Chen,Ting-Han Kuo,Chris T Ho,Hsin-Hua Chen,Sih-Jia Huang,Ho-Chieh Chiu,Chin-Chu Chen,Eric Hwang
Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates
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Chemical transformation of cannabidiol into psychotropic cannabinoids under acidic reaction conditions: Identification of transformed products by GC-MS. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Minsun Jeong,Sangin Lee,Chaeyoung Seo,Eunjeong Kwon,Soohyang Rho,Mansoo Cho,Moon Yeon Kim,Wonwoong Lee,Yong Sup Lee,Jongki Hong
Recently, cannabidiol (CBD), one of the major components of the Cannabis species, has been a focus in the cannabis industry due to its various pharmacological effects. Interestingly, CBD can be converted into several psychoactive cannabinoids, such as 9-tetrahydrocannabinol (Δ9-THC) and its structural isomers, under acidic reaction conditions. In this study, chemical transformation of CBD in ethanol
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Recent developments in detection and therapeutic approaches for antibiotic-resistant bacterial infections. J. Food Drug Anal. (IF 3.6) Pub Date : 2023-03-15 Kavya Moorthy,Kai-Chih Chang,Hsueh-Hui Yang,Wen-Min Su,Cheng-Kang Chiang,Zhiqin Yuan
Owing to the widespread emergence and proliferation of antibiotic-resistant bacteria, the therapeutic benefits of antibiotics have been reduced. In addition, the ongoing evolution of multidrug-resistant pathogens poses a challenge for the scientific community to develop sensitive analytical methods and innovative antimicrobial agents for the detection and treatment of drug-resistant bacterial infections
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Microbial toxins in fermented foods: health implications and analytical techniques for detection. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-11-23 Khadijah Fayyaz,Asad Nawaz,Amin N Olaimat,Kashif Akram,Umar Farooq,Mehreen Fatima,Shahida Anusha Siddiqui,Insha Shakeel Rana,Mahnoor Mahnoor,Hafiz Muhammad Shahbaz
Recently, demand for fermented foods has increased due to their improved nutritional value, taste, and health-promoting properties. Worldwide consumption of these products is increasing. Fermented foods are generally safe for human consumption. However, some toxins, primarily biogenic amines (putrescine, phenylethylamine, histamine, tyramine, and cadaverine), mycotoxins (fumonisins, aflatoxins, ochratoxin
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Recent trends in analysis of mycotoxins in food using carbon-based nanomaterials. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-11-23 Bing-Huei Chen,Baskaran Stephen Inbaraj
Mycotoxins (MYTs), a class of low molecular weight secondary metabolites produced by filamentous fungi in food and feed, pose serious global threat to both human health and world economy. Due to their mutagenic, teratogenic, carcinogenic and immunosuppressive effects, the International Agency for Research on Cancer has classified various MYTs under Group 1 to 3 category with aflatoxins being designated
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Recent advances in the analysis of polycyclic aromatic hydrocarbons in food and water. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-11-23 Bing-Huei Chen,Baskaran Stephen Inbaraj,Kuo-Chiang Hsu
Polycyclic aromatic hydrocarbons (PAHs), a class of harmful and persistent organic contaminant, are widely distributed in the environment and eventually accumulated in water and food. Also, they are formed in different varieties and varying amounts during processing of food depending on the food composition, cooking method and processing condition. According to the International Agency for Research
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Optimization of QuEChERS and high performance liquid chromatography-fluorescence detection conditions to assess the impact of preparation procedures on EU priority PAHs in coffee samples and their PAHs consumption risk. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-11-23 Ying-Chun Wan,Zwe-Lin Kong,Yu-Hsuan Chao,Chia-Fang Teng,Deng-Jye Yang
The good performance conditions for determination of EU priority PAHs in coffee samples were established to evaluate the effects of roasting degree on the PAHs in coffee beans and the brewing methods on the PAHs transfer from coffee beans to their brews. The consumption risk of the PAHs in coffee products was also assessed. The PAHs levels of the roasted coffee beans were in the order: 923.65 ng/g
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Simple and rapid detection of ractopamine in pork with comparison of LSPR and LFIA sensors. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-11-23 Min Ji Lee,Sheik Aliya,Eun-Seon Lee,Tae-Joon Jeon,Mi-Hwa Oh,Yun Suk Huh
This study developed a simple and rapid strategic technique to detect ractopamine (chemical growth-promoting agent) in pork. Two highly sensitive and specific gold nanoparticle-based portable sensors, i.e., localized surface plasmon resonance (LSPR) sensors, and lateral flow immunoassay (LFIA) strips were developed to detect veterinary drug residues in food products, that have detrimental effects on
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Recent advances in immunoassay-based mycotoxin analysis and toxicogenomic technologies. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-11-23 Winnie-Pui-Pui Liew,Mohd-Redzwan Sabran
The co-occurrence and accumulation of mycotoxin in food and feed constitutes a major issue to food safety, food security, and public health. Accurate and sensitive mycotoxins analysis can avoid toxin contamination as well as reduce food wastage caused by false positive results. This mini review focuses on the recent advance in detection methods for multiple mycotoxins, which mainly depends on immunoassay
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Effect of sterilization conditions on the formation of furan and its derivatives in canned foods with different substrates. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-11-23 Wen-Xuan Tsao,Bing-Huei Chen,Tsai-Hua Kao
This study explored the effects of sterilization conditions on the formation of furan and its 10 derivatives in canned foods with a sterilizing value (F0) at 4. The contents of furans were determined by SPME arrow-GC-MS/MS, along with the furan precursors analyzed for elucidating the possible mechanism of furan formation. Results revealed that the total furan contents rose substantially in canned meat
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Optimum synthesis of Au@Ag nanoparticle as plasma amplifier to detect trace concentration of AFB1 via object-binder-metal SERS method. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-11-23 Wenwen Chen,Qiang Chen,Wei Zhang,De Zhang,Zhi Yu,Ying Song,Xiubing Zhang,Dejiang Ni,Pei Liang
The problem of aflatoxin contamination emerged gradually in the field of food safety. Surface-enhanced Raman spectroscopy (SERS) is an ultra-sensitive and non-destructive spectroscopy technology with extensive application prospects in the detection field. In this paper, with the detection of AFB1 as the target, Au@Ag NPs substrate with uniform morphology and strong SERS effect was prepared. Furthermore
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Analysis of highly polar pesticides in foods by LC-MS/MS. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-11-23 Wan-Rou Liao,Kuan-Lu Wu,Kun-Hao Chiang,Chieh-En Teng,Sung-Fang Chen
Highly polar pesticides (HPP) are a group of pesticides that are characterize as low Log Kow. Many high-throughput multi-residue analysis methods based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of such polar pesticides have been proposed. In this article, we summarize the various sample preparation methods including quick polar pesticides (QuPPe)
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Ulva prolifera polysaccharide exerts anti-obesity effects via upregulation of adiponectin expression and gut microbiota modulation in high-fat diet-fed C57BL/6 mice. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Hai-Ching Pung,Wei-Sheng Lin,Yi-Chen Lo,Cheng-Chih Hsu,Chi-Tang Ho,Min-Hsiung Pan
Obesity is characterized by metabolic disorder and accompanying an altered and less diverse gut microbiota composition during a fat-enriched diet. Recent studies indicated that sulphated polysaccharide prevents high-fat diet (HFD) induced obesity, reduces metabolic disorder, and restores the gut microbiota. However, there are few studies about Ulva prolifera polysaccharide (UPP) may induce anti-obesogenic
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The antihyperlipidemic equivalent combinatorial components from peel of Citrus reticulata 'Chachi'. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Ping-Ting Xiao,Yu-Jia Kuang,Shi-Yu Liu,Zhi-Shen Xie,Jin-Hua Hao,E-Hu Liu
Since the combinatorial components responsible for the antihyperlipidemic activity of Citrus reticulata 'Chachi' (CRC) peels remains unclear, we herein developed a bioactive equivalence oriented feedback screening method to discover the bioactive equivalent combinatorial components (BECCs) from CRC peels. Using palmitic acid (PA)-stimulated hepatocyte model, a combination of 5 polymethoxyflavones (PMFs)
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A substructure-based screening approach to uncover N-nitrosamines in drug substances. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Yu-Ting Kao,Shu-Fen Wang,Meng-Hsiu Wu,Shwu-Huey Her,Yi-Hsuan Yang,Chung-Hsien Lee,Hsiao-Feng Lee,An-Rong Lee,Li-Chien Chang,Li-Heng Pao
Drug substances are at risk of contamination with N-nitrosamines (NAs), well-known carcinogenic agents, during synthesis processes and/or long-term storage. Therefore, in this study, we developed an efficient data-based screening approach to systemically assess marketed products and investigated its scalability for benefiting both regulatory agencies and pharmaceutical industries. A substructure-based
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Stable carbon isotopic characterization of rice vinegar protein as an intrinsic reference for discriminating the authenticity of brewed rice vinegar. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Chun-Jen Fang,Hsin-Cheng You,Zih-Ling Huang,Che-Lun Hsu,Chia-Fen Tsai,Ya-Tze Lin,Ya-Min Kao,Su-Hsiang Tseng,Der-Yuan Wang,Nan-Wei Su
Rice vinegar plays an important role in daily life. However, some unscrupulous manufacturers may deliberately add synthetic acetic acid in vinegar products to reduce fermentation time and save production costs. To protect the rights and health of consumers, vinegar authenticity must be controlled. The rice vinegar protein was used as an intrinsic reference and its stable carbon isotope ratio (δ13Cprotein)
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Food glycomics: Dealing with unexpected degradation of oligosaccharides during sample preparation and analysis. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Yu-Ping Huang,Randall C Robinson,Daniela Barile
This study reveals that unexpected degradation of food oligosaccharides can occur during conventional glycomics workflows, including sample preparation and analysis by liquid chromatography-mass spectrometry (LC-MS). With the present investigation, we aim to alert the scientific community of the susceptibility of specific glycosidic linkages to degradation induced by heat and acid. Key standard oligosaccharides
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Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Yash Gupta,Steven Goicoechea,Jesus G Romero,Raman Mathur,Thomas R Caulfield,Daniel P Becker,Ravi Durvasula,Prakasha Kempaiah
Leishmaniasis remains a serious public health problem in many tropical regions of the world. Among neglected tropical diseases, the mortality rate of leishmaniasis is second only to malaria. All currently approved therapeutics have toxic side effects and face rapidly increasing resistance. To identify existing drugs with antileishmanial activity and predict the mechanism of action, we designed a drug-discovery
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A three-step stacking capillary electrophoresis of field-amplified sample injection, sweeping, and micellar collapse for determination of dabigatran and its active metabolite in human plasma. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Cheng-Wei Cheng,Wen-Han Feng,Wei-Hua Tang,Hwang-Shang Kou,Chun-Chi Wang,Shou-Mei Wu
A three-step stacking capillary electrophoresis (CE) composed of field-amplified sample injection, sweeping, and analyte focusing by micellar collapse (FASI-sweeping-AFMC) was developed to determine dabigatran (D) and its major active metabolite, dabigatran acyl-beta-d-glucuronide (DAG), in human plasma. After optimization and validation, this novel approach was further applied to monitor 5 real samples
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Effect of repeated Shengmai-San administration on nifedipine pharmacokinetics and the risk/benefit under co-treatment. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Hong-Jaan Wang,Elise Chia-Hui Tan,Tzu-Yi Chiang,Wei-Ching Chen,Chien-Chang Shen,Yune-Fang Ueng
Herbal interactions with nifedipine/felodipine through cytochrome P450 (CYP) 3A inhibition is significant in humans. Shengmai-San (SMS), a three-herbal formula of Chinese medicine, is commonly prescribed in Asia populations for cardiovascular disorders. This study aimed to elucidate the impact of SMS on nifedipine/felodipine treatment by the findings from rat pharmacokinetic study of nifedipine to
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Direct immersion solid-phase microextraction combined with ambient ionization tandem mass spectrometry to rapidly distinguish pesticides in serum for emergency diagnostics. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Hung Su,Hsin-Hua Lin,Lin-Jhen Su,Chia-Chen Lin,Zong-Han Jiang,Shiang-Jin Chen,Jentaie Shiea,Chi-Wei Lee
Despite the fact that carbamates and organophosphates cause acute poisoning via different mechanisms and require disparate management, they are indistinguishable by current clinical assays. Herein, direct immersion solid-phase microextraction (DI-SPME) plus thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) was developed to discern them. Both pesticides spiked in human
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The next generation beneficial actions of novel probiotics as potential therapeutic targets and prediction tool for metabolic diseases. J. Food Drug Anal. (IF 3.6) Pub Date : 2022-03-15 Hsin-Lin Cheng,Gow-Chin Yen,Shih-Chien Huang,Shiuan-Chih Chen,Chin-Lin Hsu
The prevalence of metabolic disease has rising and affected over 1,000 million populations globally. Since the metabolic disease and its related complication are board, it has become the major health hazard of modern world. However, Long term medication of metabolic disease may cause serious side effects and risk for adverse health problems. Recently, emerging studies focus on exploring the mechanistic
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In-silico efficacy of potential phytomolecules from Ayurvedic herbs as an adjuvant therapy in management of COVID-19. J. Food Drug Anal. (IF 3.6) Pub Date : 2021-12-15 Bhanu Kumar,Ankita Misra,Satyendra Pratap Singh,Yogeshwar Vikram Dhar,Poonam Rawat,Debprasad Chattopadhyay,Saroj Kanta Barik,Sharad Srivastava
The recent COVID-19 outbreak caused by SARS-CoV-2 virus has sparked a new spectrum of investigations, research and studies in multifarious directions. Efforts are being made around the world for discovery of effective vaccines/drugs against COVID-19. In this context, Ayurveda, an alternative traditional system of medicine in India may work as an adjuvant therapy in compromised patients. We selected
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Diagnostic ions guided 2D-locating strategy for characterization of chemical analogues in complex herbal medicines using liquid chromatography-ion mobility-mass spectrometry. J. Food Drug Anal. (IF 3.6) Pub Date : 2021-12-15 Meng-Ning Li,Zi-Xuan Zhang,Hui-Ying Wang,Wen Gao,Ping Li,Hua Yang
Rapid characterization of chemical analogues in potentially toxic complex matrix was essential for prevention of accidental poisoning. On the basis of the fragment ions possessed not only the same retention times (RT) but the same drift times (DT) on liquid chromatography-ion mobility-mass spectrometry (LC-IM-MS), an alternating frames (AF)-data independent acquisition (DIA) was utilized for simultaneous
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Pharmacokinetics of panduratin A following oral administration of a Boesenbergia pandurata extract to rats. J. Food Drug Anal. (IF 3.6) Pub Date : 2021-12-15 Jihyun Won,Keumhan Noh,Jae-Kwan Hwang,Beom Soo Shin,Wonku Kang
Boesenbergia pandurata and its major active ingredient, panduratin A (PAN), exhibit antibacterial, anti-oxidant, anti-inflammatory, and anti-obesity effects. We explored the time course of the plasma and tissue (in the major organs, gums and skin) concentrations of PAN after oral administration of a B. pandurata extract to rats. Model-dependent analysis was used to quantify the skin distribution of
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Recent developments in sensing of oversulfated chondroitin sulfate in heparin. A review. J. Food Drug Anal. (IF 3.6) Pub Date : 2021-12-15 Manivannan Madhu,Wei-Lung Tseng
Oversulfated chondroitin sulfate (OSCS), a non-natural sulfated glycosaminoglycan, recognizes as a significant containment in the pharmaceutical heparin, and it could trigger adverse reactions. Chromatography-, electrophoresis-, electrochemistry-, and spectroscopy-related techniques are currently available for accurate and precise analysis of a trace amount of OSCS in heparin. Recently, emerging studies
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Variations in bovine milk oligosaccharides after calving using p-aminobenzoic ethyl ester closed-ring labeling and negative ion electrospray LC/MS/MS. J. Food Drug Anal. (IF 3.6) Pub Date : 2021-12-15 Han-Ju Chien,Yi-Chun Ma,Yi-Feng Zheng,Cheng-Yu Kuo,Wei-Chen Wang,Guor-Rong Her,Chien-Chen Lai
A strategy was proposed to analyze bovine milk oligosaccharides using p-aminobenzoic ethyl ester (ABEE) closed-ring labeling and C18 capillary liquid chromatography negative ion electrospray tandem mass spectrometry. Linkage specific fragment ions were used to identify oligosaccharide isomers. By constructing the mass chromatograms using linkage specific fragment ions, isomers were differentiated based