-
Celebrating the remarkable career of Prof. Catherine Fenselau Mass Spectrom. Rev. (IF 6.6) Pub Date : 2024-03-08 Daniele Fabris
-
Erratum to “Proteomics‐based mass spectrometry profiling of SARS‐CoV‐2 infection from human nasopharyngeal samples” Mass Spectrom. Rev. (IF 6.6) Pub Date : 2024-02-23
Chatterjee, S. and Zaia, J., 2022. Proteomics-based mass spectrometry profiling of SARS-CoV-2 infection from human nasopharyngeal samples. Mass Spectrometry Reviews, 43(1):193–229. [DOI: 10.1002/mas.21813] 1. Page 2 – In the sentence “…as a disease with ambiguous etiology (Y. Huang et al., 2020)” the correct in-text citation should be “C. Huang et al., 2019” [Huang C, Wang Y, Li X, et al. 2020. Clinical
-
Advances in proteomics methods for the analysis of exhaled breath condensate Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-12-27 Edwin J. Yoo, Julie S. Kim, Stephanie Stransky, Simon Spivack, Simone Sidoli
The analysis of exhaled breath condensate (EBC) demonstrates a promising avenue of minimally invasive biopsies for diagnostics. EBC is obtained by cooling exhaled air and collecting the condensation to be utilized for downstream analysis using various analytical methods. The aqueous phase of breath contains a large variety of miscible small compounds including polar electrolytes, amino acids, cytokines
-
Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-11-28 Paola Rizzarelli, Melania Leanza, Marco Rapisarda
Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market. Therefore, additional research efforts are required to improve their performance. Mass spectrometry (MS)
-
Miniature mass spectrometers and their potential for clinical point-of-care analysis Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-08-23 Yanbing Zhai, Xinyan Fu, Wei Xu
Mass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development
-
Recent application of direct analysis in real time mass spectrometry in plant materials analysis with emphasis on traditional Chinese herbal medicine Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-08-20 Yang Wang, Shuying Liu
Direct analysis in real time (DART) represents a new generation of ionization techniques that are used to rapidly ionize small molecules under ambient environments. The combination of DART with various mass spectrometry (MS) instruments allows analyzing multiple plant materials, including traditional Chinese herbal medicines (TCHMs), under simple or no sample treatment conditions. This review discussed
-
Quantification of modified nucleotides and nucleosides by isotope dilution mass spectrometry Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-08-19 Juan M. Marchante-Gayón, Jesús Nicolás Carcelén, Helí Potes Rodríguez, Daniela Pineda-Cevallos, Laura Rodas Sánchez, Adriana González-Gago, Pablo Rodríguez-González, Jose I. García Alonso
Epigenetic modifications are closely related to certain disorders of the organism, including the development of tumors. One of the main epigenetic modifications is the methylation of DNA cytosines, 5-methyl-2′-deoxycycytidine. Furthermore, 5-mdC can be oxidized to form three new modifications, 5-(hydroxymethyl)-2′-deoxycytidine, 5-formyl-2′-deoxycytidine, and 5-carboxy-2′-deoxycytidine. The coupling
-
An update on multiplexed mass spectrometry-based lysosomal storage disease diagnosis Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-08-16 Laura Darie-Ion, Brînduşa Alina Petre
Lysosomal storage disorders (LSDs) are a type of inherited metabolic disorders in which biomolecules, accumulate as a specific substrate in lysosomes due to specific individual enzyme deficiencies. Despite the fact that LSDs are incurable, various approaches, including enzyme replacement therapy, hematopoietic stem cell transplantation, or gene therapy are now available. Therefore, a timely diagnosis
-
Direct mass spectrometry analysis of exhaled human breath in real-time Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-08-10 Xiaoping Zhang, Vladimir Frankevich, Jianhua Ding, Yuanyuan Ma, Konstantin Chingin, Huanwen Chen
The molecular composition of exhaled human breath can reflect various physiological and pathological conditions. Considerable progress has been achieved over the past decade in real-time analysis of exhaled human breath using direct mass spectrometry methods, including selected ion flow tube mass spectrometry, proton transfer reaction mass spectrometry, extractive electrospray ionization mass spectrometry
-
Tissue proteomics repositories for data reanalysis Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-08-03 Rafael Stroggilos, Aggeliki Tserga, Jerome Zoidakis, Antonia Vlahou, Manousos Makridakis
We are approaching the third decade since the establishment of the very first proteomics repositories back in the mid-'00s. New experimental approaches and technologies continuously enrich the field while producing vast amounts of mass spectrometry data. Together with initiatives to establish standard terminology and file formats, proteomics is rapidly transforming into a mature component of systems
-
Microstructure characterization and mechanistic insight into polyether polyols and their associated polyurethanes Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-08-03 Anthony P. Gies, David M. Hercules, Arjun Raghuraman, Alex J. Kosanovich, Matthew A. Baker, Sukrit Mukhopadhyay, Ilia Kobylianskii, Manjiri Paradkar
This article reviews the analytical tool chest used for characterizing alkoxylates and their associated copolymer mixtures. Specific emphasis will be placed upon the use of mass spectrometry-based techniques as rapid characterization tools for optimizing reaction processes in an industrial R&D setting. An initial tutorial will cover the use of matrix-assisted laser desorption/ionization-mass spectrometry
-
Mass spectrometry in ocular drug research Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-08-02 Eva M. del Amo, Kati-Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola
Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments. The second part of the review consists of an introduction to ocular proteomics, with special emphasis on targeted
-
What is the role of current mass spectrometry in pharmaceutical analysis? Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-07-28 Maria Khalikova, Jakub Jireš, Ondřej Horáček, Michal Douša, Radim Kučera, Lucie Nováková
The role of mass spectrometry (MS) has become more important in most application domains in recent years. Pharmaceutical analysis is specific due to its stringent regulation procedures, the need for good laboratory/manufacturing practices, and a large number of routine quality control analyses to be carried out. The role of MS is, therefore, very different throughout the whole drug development cycle
-
A tutorial: Laserspray ionization and related laser-based ionization methods for use in mass spectrometry Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-07-18 Sarah Trimpin
This Tutorial is to provide a summary of parameters useful for successful outcomes of laserspray ionization (LSI) and related methods that employ a laser to ablate a matrix:analyte sample to produce highly charged ions. In these methods the purpose of the laser is to transfer matrix-analyte clusters into the gas phase. Ions are hypothesized to be produced by a thermal process where emitted matrix:analyte
-
Recent advances in mass spectrometry techniques for atmospheric chemistry research on molecular-level Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-07-13 Wen Zhang, Lu Xu, Haofei Zhang
The Earth's atmosphere is composed of an enormous variety of chemical species associated with trace gases and aerosol particles whose composition and chemistry have critical impacts on the Earth's climate, air quality, and human health. Mass spectrometry analysis as a powerful and popular analytical technique has been widely developed and applied in atmospheric chemistry for decades. Mass spectrometry
-
Characterization of mRNA therapeutics Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-07-04 Guilherme J. Guimaraes, Jaeah Kim, Michael G. Bartlett
Therapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of complex diseases, especially for conditions that lack efficacious treatment. The successful application of this modality can be attributed to its ability to encode entire proteins. While the large nature of these molecules has supported their success as therapeutics, its extended size creates several analytical challenges
-
Ion-molecule studies of energetic oxygen allotropes in flow tubes: O2(v),O2(aΔg1),O3,andO ${{\rm{O}}}_{2}({\rm{v}}),{{\rm{O}}}_{2}({\rm{a}}{}^{1}{\rm{\Delta }}_{{\rm{g}}}),{{\rm{O}}}_{3},\mathrm{and}{\rm{O}}$ Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-07-02 Nicole Eyet, Shaun G. Ard, Nicholas S. Shuman, Albert A. Viggiano
Starting in the 1960s, flow tube apparatuses have played a central role in the study of ion-molecule kinetics, allowing for immense chemical diversity of cationic, anionic, and neutral reactants. Here, we review studies of oxygen allotropes, excluding ground state O2 ( X 3 ∑ g − ${X}^{3}{\sum }_{g}^{-}$ ), and focusing instead on reactions of cations, anions, and metal chemi-ionization reactions with
-
Peptides as “better biomarkers”? Value, challenges, and potential solutions to facilitate implementation Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-06-26 Agnieszka Latosinska, Maria Frantzi, Justyna Siwy
Peptides carry important functions in normal physiological and pathophysiological processes and can serve as clinically useful biomarkers. Given the ability to diffuse passively across endothelial barriers, endogenous peptides can be examined in several body fluids, including among others urine, blood, and cerebrospinal fluid. This review article provides an update on the recently published literature
-
Analysis of triacylglycerol and phospholipid sn-positional isomers by liquid chromatographic and mass spectrometric methodologies Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-06-06 Mikael Fabritius, Baoru Yang
Analysis of triacylglycerol (TG) and phospholipid sn-positional isomers can be divided into two main categories: (a) direct separation by chromatography or other means such as ion mobility mass spectrometry and (b) quantification of regioisomer ratios by structurally informative fragment ions with mass spectrometric methods. Due to long retention times and limited performance, researchers are moving
-
Structural studies of supramolecular complexes and assemblies by ion mobility mass spectrometry Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-06-01 Magdalena M. Zimnicka
Recent advances in instrumentation and development of computational strategies for ion mobility mass spectrometry (IM-MS) studies have contributed to an extensive growth in the application of this analytical technique to comprehensive structural description of supramolecular systems. Apart from the benefits of IM-MS for interrogation of intrinsic properties of noncovalent aggregates in the experimental
-
Quantification of snake venom proteomes by mass spectrometry-considerations and perspectives Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-05-08 Juan J. Calvete, Bruno Lomonte, Anthony J. Saviola, Francisco Calderón Celis, Jorge Ruiz Encinar
The advent of soft ionization mass spectrometry-based proteomics in the 1990s led to the development of a new dimension in biology that conceptually allows for the integral analysis of whole proteomes. This transition from a reductionist to a global-integrative approach is conditioned to the capability of proteomic platforms to generate and analyze complete qualitative and quantitative proteomics data
-
Statistical approaches applicable in managing OMICS data: Urinary proteomics as exemplary case Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-05-04 De-Wei An, Yu-Ling Yu, Dries S. Martens, Agnieszka Latosinska, Zhen-Yu Zhang, Harald Mischak, Tim S. Nawrot, Jan A. Staessen
With urinary proteomics profiling (UPP) as exemplary omics technology, this review describes a workflow for the analysis of omics data in large study populations. The proposed workflow includes: (i) planning omics studies and sample size considerations; (ii) preparing the data for analysis; (iii) preprocessing the UPP data; (iv) the basic statistical steps required for data curation; (v) the selection
-
Effects of charge on protein ion structure: Lessons from cation-to-anion, proton-transfer reactions Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-05-02 Theresa A. Gozzo, Matthew F. Bush
Collision cross-section values, which can be determined using ion mobility experiments, are sensitive to the structures of protein ions and useful for applications to structural biology and biophysics. Protein ions with different charge states can exhibit very different collision cross-section values, but a comprehensive understanding of this relationship remains elusive. Here, we review cation-to-anion
-
Mass spectrometric approaches in discovering lipid biomarkers for COVID-19 by lipidomics: Future challenges and perspectives Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-04-27 Siddabasave Gowda B. Gowda, Chandra Shekhar, Divyavani Gowda, Yifan Chen, Hitoshi Chiba, Shu-Ping Hui
Coronavirus disease 2019 (COVID-19) has emerged as a global health threat and has rapidly spread worldwide. Significant changes in the lipid profile before and after COVID-19 confirmed the significance of lipid metabolism in regulating the response to viral infection. Therefore, understanding the role of lipid metabolism may facilitate the development of new therapeutics for COVID-19. Owing to their
-
Mass spectrometry of polymers: A tutorial review Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-04-18 Chrys Wesdemiotis, Kayla N. Williams-Pavlantos, Addie R. Keating, Andrew S. McGee, Calum Bochenek
Ever since the inception of synthetic polymeric materials in the late 19th century, the number of studies on polymers as well as the complexity of their structures have only increased. The development and commercialization of new polymers with properties fine-tuned for specific technological, environmental, consumer, or biomedical applications requires powerful analytical techniques that permit the
-
Comprehensive and heart-cutting multidimensional liquid chromatography–mass spectrometry and its applications in food analysis Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-04-13 Irene Caño-Carrillo, Bienvenida Gilbert-López, Lidia Montero, Ana B. Martínez-Piernas, Juan F. García-Reyes, Antonio Molina-Díaz
In food analysis, conventional one-dimensional liquid chromatography methods sometimes lack sufficient separation power due to the complexity and heterogeneity of the analyzed matrices. Therefore, the use of two-dimensional liquid chromatography (2D-LC) turns out to be a powerful tool to consider, especially when coupled to mass spectrometry (MS). This review presents the most remarkable 2D-LC–MS food
-
Proteomics mining of cancer hallmarks on a single-cell resolution Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-04-12 Maomao Li, Jing Zuo, Kailin Yang, Ping Wang, Shengtao Zhou
Dysregulated proteome is an essential contributor in carcinogenesis. Protein fluctuations fuel the progression of malignant transformation, such as uncontrolled proliferation, metastasis, and chemo/radiotherapy resistance, which severely impair therapeutic effectiveness and cause disease recurrence and eventually mortality among cancer patients. Cellular heterogeneity is widely observed in cancer and
-
Comprehensive and heart-cutting multidimensional liquid chromatography-mass spectrometry and its applications in food analysis Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-04-03 Irene Caño-Carrillo, Bienvenida Gilbert-López, Lidia Montero, Ana B. Martínez-Piernas, Juan F. García-Reyes, Antonio Molina-Díaz
In food analysis, conventional one-dimensional liquid chromatography methods sometimes lack sufficient separation power due to the complexity and heterogeneity of the analysed matrices. Therefore, the use of two-dimensional liquid chromatography (2D-LC) turns out to be a powerful tool to consider, especially when coupled to mass spectrometry (MS). This review presents the most remarkable 2D-LC-MS food
-
Probe-based mass spectrometry approaches for single-cell and single-organelle measurements Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-04-03 Daniel C. Castro, Peter Chan-Andersen, Elena V. Romanova, Jonathan V. Sweedler
Exploring the chemical content of individual cells not only reveals underlying cell-to-cell chemical heterogeneity but is also a key component in understanding how cells combine to form emergent properties of cellular networks and tissues. Recent technological advances in many analytical techniques including mass spectrometry (MS) have improved instrumental limits of detection and laser/ion probe dimensions
-
Innovations in Applications of Mass Spectrometry Impact Many Fields of Science. Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-03-17 Catherine Fenselau Cotter
I am pleased and honored that Dan Fabris has organized this special issue of reviews that reflect many of my research interests. I have been a member of the Editorial Advisory Board of Mass Spectrometry Reviews since 1994 and I regard reviews as an important component of the scientific method. Well done, they collect and integrate knowledge in a particular field and construct a factual foundation that
-
Editorial from Dominic M. Desiderio Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-03-17 Dom Desiderio
I retired as an Editor of Mass Spectrometry Reviews. I signed my contract on November 1, 1993, and published my first editorial (Volume 13, Issue 1, 1994) when I joined Nico M. M. Nibbering as Co-Editor. These two editorials frame my 30-year tenure at the journal.
-
Measurement and utilization of the proteomic reactivity by mass spectrometry Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-03-16 Clodette Punzalan, Lei Wang, Bekim Bajrami, Xudong Yao
Chemical proteomics, which involves studying the covalent modifications of proteins by small molecules, has significantly contributed to our understanding of protein function and has become an essential tool in drug discovery. Mass spectrometry (MS) is the primary method for identifying and quantifying protein-small molecule adducts. In this review, we discuss various methods for measuring proteomic
-
Mass spectrometry analysis of phosphotyrosine-containing proteins Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-02-14 Jiajia Li, Xianquan Zhan
Tyrosine phosphorylation is a crucial posttranslational modification that is involved in various aspects of cell biology and often has functions in cancers. It is necessary not only to identify the specific phosphorylation sites but also to quantify their phosphorylation levels under specific pathophysiological conditions. Because of its high sensitivity and accuracy, mass spectrometry (MS) has been
-
Recent developments and applications of selected ion flow tube mass spectrometry (SIFT-MS) Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-02-12 David Smith, Patrik Španěl, Nicholas Demarais, Vaughan S. Langford, Murray J. McEwan
Selected ion flow tube mass spectrometry (SIFT-MS) is now recognized as the most versatile analytical technique for the identification and quantification of trace gases down to the parts-per-trillion by volume, pptv, range. This statement is supported by the wide reach of its applications, from real-time analysis, obviating sample collection of very humid exhaled breath, to its adoption in industrial
-
The isotope distribution: A rose with thorns Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-02-06 Jürgen Claesen, Alan Rockwood, Mikhail Gorshkov, Dirk Valkenborg
The isotope distribution, which reflects the number and probabilities of occurrence of different isotopologues of a molecule, can be theoretically calculated. With the current generation of (ultra)-high-resolution mass spectrometers, the isotope distribution of molecules can be measured with high sensitivity, resolution, and mass accuracy. However, the observed isotope distribution can differ substantially
-
Characterization of the degradation products of lignocellulosic biomass by using tandem mass spectrometry experiments, model compounds, and quantum chemical calculations Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-02-02 Jacob D. Guthrie, Caroline E. R. Rowell, Ruth O. Anyaeche, Kawthar Z. Alzarieni, Hilkka I. Kenttämaa
Biomass-derived degraded lignin and cellulose serve as possible alternatives to fossil fuels for energy and chemical resources. Fast pyrolysis of lignocellulosic biomass generates bio-oil that needs further refinement. However, as pyrolysis causes massive degradation to lignin and cellulose, this process produces very complex mixtures. The same applies to degradation methods other than fast pyrolysis
-
Probing gas phase catalysis by atomic metal cations with flow tube mass spectrometry Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-01-31 Voislav Blagojevic, Gregory K. Koyanagi, Diethard K. Böhme
The evolution and applications of flow tube mass spectrometry in the study of catalysis promoted by atomic metal ions are tracked from the pioneering days in Boulder, Colorado, to the construction and application of the ICP/SIFT/QqQ and ESI/qQ/SIFT/QqQ instruments at York University and the VISTA-SIFT instrument at the Air Force Research Laboratory. The physical separation of various sources of atomic
-
Periodic trends in the hydration energies and critical sizes of alkaline earth and transition metal dication water complexes Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-01-16 Fan Yang, P. B. Armentrout
This review encompasses guided ion beam tandem mass spectrometry studies of hydrated metal dication complexes. Metals include the Group 2 alkaline earths (Mg, Ca, Sr, and Ba), late first-row transition metals (Mn, Fe, Co, Ni, Cu, and Zn), along with Cd. In all cases, threshold collision-induced dissociation experiments are used to quantitatively determine the sequential hydration energies for M2+(H2O)x
-
Biological mass spectrometry enables spatiotemporal ‘omics: From tissues to cells to organelles Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-01-16 Leena R. Pade, Kaitlyn E. Stepler, Erika P. Portero, Kellen DeLaney, Peter Nemes
Biological processes unfold across broad spatial and temporal dimensions, and measurement of the underlying molecular world is essential to their understanding. Interdisciplinary efforts advanced mass spectrometry (MS) into a tour de force for assessing virtually all levels of the molecular architecture, some in exquisite detection sensitivity and scalability in space-time. In this review, we offer
-
A Special Issue Honoring Prof. Hilkka Kenttämaa for Her Contributions to the Field of Mass Spectrometry Mass Spectrom. Rev. (IF 6.6) Pub Date : 2023-01-05 Edouard Niyonsaba
In this special issue of Mass Spectrometry Reviews honoring Prof. Hilkka Kenttämaa for her contributions to Mass Spectrometry, I have invited many leading researchers in different fields of mass spectrometry that reflect Prof. Hilkka Kenttämaa's diverse research background.
-
Mass spectrometry-based methods to characterize highly heterogeneous biopharmaceuticals, vaccines, and nonbiological complex drugs at the intact-mass level Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-12-29 Igor A. Kaltashov, Daniil G. Ivanov, Yang Yang
The intact-mass MS measurements are becoming increasingly popular in characterization of a range of biopolymers, especially those of interest to biopharmaceutical industry. However, as the complexity of protein therapeutics and other macromolecular medicines increases, the new challenges arise, one of which is the high levels of structural heterogeneity that are frequently exhibited by such products
-
Mass spectrometry for metabolomics analysis: Applications in neonatal and cancer screening Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-12-16 Alexander J. Grooms, Benjamin J. Burris, Abraham K. Badu-Tawiah
Chemical analysis by analytical instrumentation has played a major role in disease diagnosis, which is a necessary step for disease treatment. While the treatment process often targets specific organs or compounds, the diagnostic step can occur through various means, including physical or chemical examination. Chemically, the genome may be evaluated to give information about potential genetic outcomes
-
Gas-phase Förster resonance energy transfer in mass-selected and trapped ions Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-12-13 Jeppe Langeland, Thomas T. Lindkvist, Christina Kjær, Steen Brøndsted Nielsen
Förster Resonance Energy transfer (FRET) is a nonradiative process that may occur from an electronically excited donor to an acceptor when the emission spectrum of the donor overlaps with the absorption spectrum of the acceptor. FRET experiments have been done in the gas phase based on specially designed mass-spectroscopy setups with the goal to obtain structural information on biomolecular ions labeled
-
Clinical proteomics towards multiomics in cancer Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-12-10 Chad J. Creighton
Recent technological advancements in mass spectrometry (MS)-based proteomics technologies have accelerated its application to study greater and greater numbers of human tumor specimens. Over the last several years, the Clinical Proteomic Tumor Analysis Consortium, the International Cancer Proteogenome Consortium, and others have generated MS-based proteomic profiling data combined with corresponding
-
Chemical compositional analysis of jet fuels: Contributions of mass spectrometry in the 21st century Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-12-02 Mark Romanczyk
Jet fuels are complex mixtures composed of many individual compounds that influence crucial chemical and physical properties. Approximately over the last 20 years, mass spectrometry studies provided important and extensive qualitative and quantitative information of the compounds that make up jet fuels. This review presents these main findings, evaluates the analytical methods utilized, and summarizes
-
Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2019–2020 Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-12-05 David J. Harvey
This review is the tenth update of the original article published in 1999 on the application of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2020. Also included are papers that describe methods appropriate to analysis by MALDI, such as sample preparation techniques, even
-
Mass spectrometry-based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-11-29 Paras Ahmad, Ahmed Hussain, Walter L. Siqueira
Dental caries is a multifactorial chronic disease resulting from the intricate interplay among acid-generating bacteria, fermentable carbohydrates, and several host factors such as saliva. Saliva comprises several proteins which could be utilized as biomarkers for caries prevention, diagnosis, and prognosis. Mass spectrometry-based salivary proteomics approaches, owing to their sensitivity, provide
-
Ion-molecule reactions of mass-selected ions Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-11-29 Kevin Parker, Nicholas E. Bollis, Victor Ryzhov
Gas-phase reactions of mass-selected ions with neutrals covers a very broad area of fundamental and applied mass spectrometry (MS). Oftentimes, ion-molecule reactions (IMR) can serve as a viable alternative to collision-induced dissociation and other ion dissociation techniques when using tandem MS. This review focuses on the literature pertaining applications of IMR since 2013. During the past decade
-
Characterization of the dystrophin-associated protein complex by mass spectrometry Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-11-24 Emily H. Canessa, Rita Spathis, James S. Novak, Aaron Beedle, Kanneboyina Nagaraju, Luca Bello, Elena Pegoraro, Eric P. Hoffman, Yetrib Hathout
The dystrophin-associated protein complex (DAPC) is a highly organized multiprotein complex that plays a pivotal role in muscle fiber structure integrity and cell signaling. The complex is composed of three distinct interacting subgroups, intracellular peripheral proteins, transmembrane glycoproteins, and extracellular glycoproteins subcomplexes. Dystrophin protein nucleates the DAPC and is important
-
Synthetic dyes: A mass spectrometry approach and applications Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-11-10 Zoe Millbern, Alison Trettin, Rachel Wu, Morgan Demmler, Nelson R. Vinueza
Synthetic dyes are found in a wide variety of applications today, including but not limited to textiles, foods, and medicine. The analysis of these molecules is pertinent to several fields such as forensics, environmental monitoring, and quality control, all of which require the sensitivity and selectivity of analysis provided by mass spectrometry (MS). Recently, there has been an increase in the implementation
-
Reminiscence on Frantisek Tureček Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-10-11 Ivan K. Chu
I have known Frank for more than 20 years since my first foray into the generation and chemistry of peptide radical ions (Chu et al., 2000).
-
A tribute to Frantisek “Frank” Turecek, a scientist and a mountaineer Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-10-11 Martin Sadilek, Michael Volny, Victor Ryzhov
It was in the mid-eighties at the Heyrovsky Institute of the Czechoslovak Academy of Sciences in Prague when I (M.S.) first remember meeting Frantisek as a guest speaker in Prof. Zdenek Herman's office.
-
How I Have Learnt to Ignore Bibliometrics Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-10-11 František Tureček
In 1970, when I started doing research in physical organic chemistry as an undergraduate at the Natural Sciences Faculty of Charles University in Prague, the various forms of bibliometrics, such as impact factors, citation indexes, and the h-factor, were unknown.
-
Using mass spectrometry-based methods to understand amyloid formation and inhibition of alpha-synuclein and amyloid beta Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-10-12 Wesley J. Wagner, Michael L. Gross
Amyloid fibrils, insoluble β-sheets structures that arise from protein misfolding, are associated with several neurodegenerative disorders. Many small molecules have been investigated to prevent amyloid fibrils from forming; however, there are currently no therapeutics to combat these diseases. Mass spectrometry (MS) is proving to be effective for studying the high order structure (HOS) of aggregating
-
Proteomics-based mass spectrometry profiling of SARS-CoV-2 infection from human nasopharyngeal samples Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-09-29 Sayantani Chatterjee, Joseph Zaia
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the on-going global pandemic of coronavirus disease 2019 (COVID-19) that continues to pose a significant threat to public health worldwide. SARS-CoV-2 encodes four structural proteins namely membrane, nucleocapsid, spike, and envelope proteins that play essential roles in viral entry, fusion, and attachment to the host cell
-
Uncommon posttranslational modifications in proteomics: ADP-ribosylation, tyrosine nitration, and tyrosine sulfation Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-09-27 Aarti Bashyal, Jennifer S. Brodbelt
Posttranslational modifications (PTMs) are covalent modifications of proteins that modulate the structure and functions of proteins and regulate biological processes. The development of various mass spectrometry-based proteomics workflows has facilitated the identification of hundreds of PTMs and aided the understanding of biological significance in a high throughput manner. Improvements in sample
-
Development of mass spectrometric glycan characterization tags using acid-base chemistry and/or free radical chemistry Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-09-26 Rayan Murtada, Shane Finn, Jinshan Gao
Despite recent advances in glycomics, glycan characterization still remains an analytical challenge. Accordingly, numerous glycan-tagging reagents with different chemistries were developed, including those involving acid-base chemistry and/or free radical chemistry. Acid-base chemistry excels at dissociating glycans into their constituent components in a systematic and predictable manner to generate
-
Inferring kinase activity from phosphoproteomic data: Tool comparison and recent applications Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-09-26 Sander R. Piersma, Andrea Valles-Marti, Frank Rolfs, Thang V. Pham, Alex A. Henneman, Connie R. Jiménez
Aberrant cellular signaling pathways are a hallmark of cancer and other diseases. One of the most important signaling mechanisms involves protein phosphorylation/dephosphorylation. Protein phosphorylation is catalyzed by protein kinases, and over 530 protein kinases have been identified in the human genome. Aberrant kinase activity is one of the drivers of tumorigenesis and cancer progression and results
-
Mass spectrometry for the study of adipocyte cell secretome in cardiovascular diseases Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-09-26 Erica Gianazza, Maura Brioschi, Sonia Eligini, Cristina Banfi
Adipose tissue is classically considered the primary site of lipid storage, but in recent years has garnered appreciation for its broad role as an endocrine organ, capable of remotely signaling to other tissues to alter their metabolic program. The adipose tissue is now recognized as a crucial regulator of cardiovascular health, mediated by the secretion of several bioactive products, with a wide range
-
Advances in mass spectrometry imaging for toxicological analysis and safety evaluation of pharmaceuticals Mass Spectrom. Rev. (IF 6.6) Pub Date : 2022-09-22 Yilin Chen, Yanqiao Xie, Linnan Li, Zhengtao Wang, Li Yang
Safety issues caused by pharmaceuticals have frequently occurred worldwide, posing a tremendous threat to human health. As an essential part of drug development, the toxicological analysis and safety evaluation is of great significance. In addition, the risk of pharmaceuticals accumulation in the environment and the monitoring of the toxicity from natural medicines have also received ongoing concerns