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Promising aryl selenoate derivatives as antileishmanial agents and their effects on gene expression Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-18 Celia Fernández-Rubio, Mercedes Rubio-Hernández, Verónica Alcolea, Aroia Burguete-Mikeo, Paul A. Nguewa, Silvia Pérez-Silanes
Selenium (Se) is an essential trace element that has been demonstrated to be involved in several pathological conditions, such as cancer and cardiovascular or thyroid diseases, due to its anti-inflammatory, pro-immune, and antioxidant properties (1–5). Most organic Se exerts its effects through its joining to the selenoprotein synthesis pathway as selenocysteine, a naturally occurring amino acid analog
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Efficacy and effect on lipid profiles of switching to ainuovirine-based regimen versus continuing efavirenz-based regimen in people with HIV-1: 24-week results from a real-world, retrospective, multi-center cohort study Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-14 Chunmei WangXiaoli YuYingchun KeYanhua FuYanhe LuoYing LiYanmei BiXingqiong ChenLinghua LiXiuhong ZhaoZhong Chen1Department of Dermatology, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China2Department of Infection and Immunology with Chinese Integrative Medicine, Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Opportunistic dried blood spot sampling validates and optimizes a pediatric population pharmacokinetic model of metronidazole Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-13 Rachel L. Randell Stephen J. Balevic Rachel G. Greenberg Michael Cohen-Wolkowiez Elizabeth J. Thompson Saranya Venkatachalam Michael J. Smith Catherine Bendel Joseph M. Bliss Hala Chaaban Rakesh Chhabra Christiane E. L. Dammann L. Corbin Downey Chi Hornik Naveed Hussain Matthew M. Laughon Adrian Lavery Fernando Moya Matthew Saxonhouse Gregory M. Sokol Andrea Trembath Joern-Hendrik Weitkamp Christoph
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Deciphering the molecular and functional basis of TMexCD1: the plasmid-encoded efflux pump of resistance-nodulation-division superfamily Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-13 Yan ShangYe ZhangRuimin WangYishu PengBo DingYuanxiang LiuChongzhou LiLuhua FengHonglei LiuChunyu YangYajie Tang1State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao, China2Poultry Institute, Shandong Academy of Agricultural Sciences, Jinan, China3Shandong Institute for Food and Drug Control, Jinan, China4School of Pharmaceutical Sciences, Shandong
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Murepavadin promotes the killing efficacies of aminoglycoside antibiotics against Pseudomonas aeruginosa by enhancing membrane potential Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-12 Xiaoya WeiJiacong GaoDandan ZhouCongjuan XuPing ChenShuiping ChenYanhong ZhangXuehua LiuGuanxian LiGuangbo ZhuHuimin LiuJinjin LiBin GengLinlin GaoZhihui ChengIain L. LamontDaniel PletzerYongxin JinShouguang JinWeihui Wu1State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Sub-MIC levels of bedaquiline and clofazimine can select Mycobacterium tuberculosis mutants with increased MIC Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-12 Cristina VillellasFrederik StevenaertBart RemmerieKoen Andries1Janssen Research and Development, Beerse, Belgium, Sean Wasserman
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Pseudomonas aeruginosa ventricular assist device infections: findings from ineffective phage therapies in five cases Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-12 Saima AslamDwayne RoachMikeljon P. NikolichBiswajit BiswasRobert T. SchooleyKimberley A. Lilly-BishopGregory K. RiceRegina Z. CerTheron HamiltonMatthew HenryTiffany LuongAnn-Charlott SalabarriaLaura Sisk-HackworthAndrey A. FilippovFrancois LebretonLindsey HallRan Nir-PazHadil OnallahGilat LivniEran ShostakAnat Wieder-FinesodDafna YahavOrtal YerushalmySivan Alkalay-OrenRon BraunsteinLeron KhalifaAmit
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Two-way pharmacodynamic modeling of drug combinations and its application to pairs of repurposed Ebola and SARS-CoV-2 agents Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-12 Shuang XuShadisadat EsmaeiliE. Fabian Cardozo-OjedaAshish GoyalJudith M. WhiteStephen J. PolyakJoshua T. Schiffer1Fred Hutchinson Cancer Research Center, Vaccine and Infectious Diseases Division, Seattle, Washington, USA2Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA3Department of Cell Biology, University of Virginia, Charlottesville, Virginia, USA4Virology Division
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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A panel of janus kinase inhibitors identified with anti-inflammatory effects protect mice from lethal influenza virus infection Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-12 Yang YuSi ChenHaonan ZhangYuanyuan DuanZhuogang LiLefang JiangWeihua CaoQun PengXulin Chen1Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China2State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, Miguel Angel Martinez
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Pharmacokinetics of long-acting lenacapavir in participants with hepatic or renal impairment Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-08 Vamshi JogirajuElijah WeberJason HindmanSteve WestJohn LingMartin RheeSandhya GirishRamesh PalaparthyRenu Singh1Gilead Sciences, Inc., Foster City, California, USA, Miguel Angel Martinez
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Hydrogen sulfide production does not affect antibiotic resistance in Pseudomonas aeruginosa Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-06 Lorenzo CarusoMarta MelliniOrtensia Catalano GonzagaAlessandra AstegnoElena ForteAdele Di MatteoAlessandro GiuffrèPaolo ViscaFrancesco ImperiLivia LeoniGiordano Rampioni1Department of Science, University Roma Tre, Rome, Italy2Department of Biotechnology, University of Verona, Verona, Italy3Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy4CNR Institute of Molecular Biology
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-06 Wen-Fang TangYu-Hsiu ChangCheng-Chin LinJia-Rong JhengChung-Fan HsiehYuan-Fan ChinTein-Yao ChangJin-Ching LeePo-Huang LiangChia-Yi LinGuan-Hua LinJie-Yun CaiYu-Li ChenYuan-Siao ChenShan-Ko TsaiPing-Cheng LiuChuen-Mi YangTolou ShadbahrJing TangYu-Lin HsuChih-Heng HuangLing-Yu WangCheng Cheung ChenJyh-Hwa KauYi-Jen HungHsin-Yi LeeWen-Chieh WangHui-Ping TsaiJim-Tong Horng1Research Center for Emerging
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Inter-phylum circulation of a beta-lactamase-encoding gene: a rare but observable event Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-05 Rémi GschwindMarie PetitjeanClaudine FournierJulie LaoOlivier ClermontPatrice NordmannAlexander MellmannErick DenamurLaurent PoirelEtienne Ruppé1Université Paris Cité, INSERM, Université Sorbonne Paris Nord, IAME, Paris, France2AP-HP, Hôpital Bichat, Laboratoire de Bactériologie, Paris, France3Emerging Antibiotic Resistance, Medical and Molecular Microbiology, Faculty of Science and Medicine, University
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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In vitro activity of meropenem-vaborbactam plus aztreonam against metallo-β-lactamase-producing Klebsiella pneumoniae Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-03-01 Astrid V. Cienfuegos-GalletElena ShashkinaTingyu ChuZhichen ZhuBingjie WangBarry N. KreiswirthLiang Chen1Hackensack Meridian Health Center for Discovery and Innovation, Nutley, New Jersey, USA2School of Microbiology, University of Antioquia, Medellín, Colombia3The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China4Department of Clinical Laboratory Medicine, Shanghai Pulmonary
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Therapeutic response to four artemisinin-based combination therapies in Angola, 2021 Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-29 Pedro Rafael DimbuSarah LabudaCarolina Miguel FerreiraFelismina CaqueceKialanda AndréGarcia PembeleDilunvuidi PodeMaria Florinda JoãoVenceslau Mambi PelendaBenjamin Nieto AndradeBreanna HortonCulzean KennedySamaly S. SvigelZhiyong ZhouJoana F. M. MoraisJoana do RosárioFilomeno FortesJosé Franco MartinsMateusz M. Plucinski1National Malaria Control Program, Ministry of Health, Luanda, Angola2United States
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-28 Jayathilake SarangiAyaka IdoMasaya ItoChihiro IinumaYo DoyamaWanchun JinJun-ichi WachinoMasahiro SuzukiMitsutaka IguchiTetsuya YagiYoshichika ArakawaKouji Kimura1Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan2Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan3Department of Infectious Diseases, Nagoya University Graduate
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Effect of modification of penicillin-binding protein 3 on susceptibility to ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam, aztreonam-avibactam, cefepime-taniborbactam, and cefiderocol of Escherichia coli strains producing broad-spectrum β-lactamases Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-28 Christophe Le TerrierPatrice NordmannChloé BuchsLaurent Poirel1Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland2Division of Intensive Care Unit, University Hospitals of Geneva, Geneva, Switzerland3Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland, Alessandra
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Host defense peptides mitigate the spread of antibiotic resistance in physiologically relevant condition Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-28 Miao ZhangBingqing YangJingru ShiZhiqiang WangYuan Liu1Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, China2Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, China3Institute of Comparative
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Population pharmacokinetic rationale for intravenous contezolid acefosamil followed by oral contezolid dosage regimens Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-28 Jürgen B. BulittaEdward FangMartin E. StryjewskiWen WangGeorge J. AtieeJeffrey G. StarkBarry Hafkin1Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA2MicuRx Pharmaceuticals, Inc., Foster City, California, USA3Department of Medicine, Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clínicas, Buenos
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Balancing the scales: achieving the optimal beta-lactam to beta-lactamase inhibitor ratio with continuous infusion piperacillin/tazobactam against extended spectrum beta-lactamase producing Enterobacterales Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-27 Pier Giorgio CojuttiManjunath P. PaiTommaso TonettiAntonio SiniscalchiPierluigi VialeFederico Pea1Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy2Clinical Pharmacology Unit, IRCCS Azienda Ospedaliero—Universitaria di Bologna, Bologna, Italy3Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA4Anesthesiology
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Ethambutol and meropenem/clavulanate synergy promotes enhanced extracellular and intracellular killing of Mycobacterium tuberculosis Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-27 Francisco OlivençaDavid PiresCátia SilveiroBianca GamaFrederico HoltremanElsa AnesMaria João Catalão1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal2Universidade Católica Portuguesa, Católica Medical School, Centre for Interdisciplinary Research in Health, Lisbon, Portugal, Sean Wasserman
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Delayed gametocyte clearance in Plasmodium vivax malaria is associated with polymorphisms in the cytochrome P450 reductase (CPR) Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-27 Yanka Evellyn Alves Rodrigues SalazarJaime LouzadaMaria Carolina Silva de Barros PuçaLuiz Felipe Ferreira GuimarãesJosé Luiz Fernandes VieiraAndré Machado de SiqueiraJosé Pedro GilCristiana Ferreira Alves de BritoTais Nobrega de Sousa1Molecular Biology and Malaria Immunology Research Group, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Belo Horizonte, Minas Gerais, Brazil2Universidade Federal
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-27 A. Fabrice SoméMelissa D. ConradZachari KabréAminata FofanaR. Serge YerbangaThomas BaziéCatherine NeyaMyreille SoméTegawinde Josue KagambegaJenny LegacShreeya GargJeffrey A. BaileyJean-Bosco OuédraogoPhilip J. RosenthalRoland A. Cooper1Institut de Recherche en Sciences de la Santé, Direction Régionale de l’Ouest, Bobo-Dioulasso, Burkina Faso2Department of Medicine, University of California, San Francisco
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Amoebicidal effect of synthetic indoles against Acanthamoeba spp.: a study of cell death Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-27 Ines SifaouiRubén L. Rodríguez-ExpósitoMaría Reyes-BatlleAlejandra Dumpiérrez RamosRaquel Diana-RiveroFernando García-TelladoDavid TejedorJosé E. PiñeroJacob Lorenzo-Morales1Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain2Departamento de Obstetricia y Ginecología, Pediatría, Medicina Preventiva y Salud
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Impact of hypoalbuminemia on clinical outcomes among patients with obesity treated with ceftriaxone Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-27 Kellie Arensman HannanEvan DraperKristin C. ColeJack Mc HughChristina G. RiveraOmar Abu Saleh1Department of Pharmacy, Mayo Clinic Health System, Mankato, Minnesota, USA2Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA3Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA4Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Antibiotic-induced ROS-mediated Fur allosterism contributes to Helicobacter pylori resistance by inhibiting arsR activation of mutS and mutY Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-22 Junyuan XueWen LiYican ZhaoLiyuan WangPeiyuan ChengLu ZhangYantong ZhengWenxin ZhangYakun BiZhenghong ChenTing JiangYundong Sun1Department of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, School of Basic Medical Science, Shandong University, Jinan, Shandong, China2Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Jilin
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Proactive therapeutic monitoring of dalbavancin concentrations in the long-term management of chronic osteoarticular/periprosthetic joint infections Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-22 Dario CattaneoMarta FusiLucia GalliCamilla GenoveseRiccardo GiorgiMaddalena MatoneStefania MerliMarta ColaneriAndrea Gori1Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy2Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan, Italy, James E. Leggett
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Bimodal distribution of azole susceptibility in Sporothrix brasiliensis isolates in Brazil Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-22 Amanda Ribeiro dos SantosLalitha GadeElizabeth MisasAnastasia P. LitvintsevaNatalie S. NunnallyLindsay A. ParnellMalavika RajeevMarcia de Souza Carvalho MelhemJuliana Possato Fernandes TakahashiGabriel Manzi OliboniLucas Xavier BonfietiLisandra Siufi AraujoPaola CappellanoJames VenturiniShawn R. LockhartD. Joseph Sexton1Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee, USA2Mycotic
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-21 Andrew MulatoEric LansdonRon AoyamaJohannes VoigtMichael LeeAlbert LiclicanGary LeeEric SingerBrian StaffordRuoyu GongBernard MurrayJulie ChanJohnny LeeYili XuShekeba AhmadyarAna GonzalezAesop ChoGeorge J. StepanUli SchmitzBrian SchultzBruno MarchandBoris BrumshteinRuth WangHelen YuTomas CihlarLianhong XuStephen R. Yant1Department of Virology, Gilead Sciences, Foster City, California, USA2Department
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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A phase 1 study in healthy volunteers to investigate the safety, tolerability, and pharmacokinetics of VIR-2482: a monoclonal antibody for the prevention of severe influenza A illness Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-20 David PlotnikJennifer E. SagerMadhukar AryalMarie C. FangetAlessia PeterMichael A. SchmidDeborah CebrikErik MogalianKeith BoundyWendy W. YehPaul GriffinMaribel Reyes1Vir Biotechnology, San Francisco, California, USA2Humabs BioMed, SA, Vir Biotechnology, Bellinzona, Switzerland3Mater Health and University of Queensland, Queensland, Australia, James E. Leggett
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-20 Si-Yang LiSandeep TyagiHeena SoniFabrice BetoudjiPaul J. ConverseKhisimuzi MdluliAnna M. UptonNader FotouhiDavid Barros-AguirreLluís BallellElena Jimenez-NavarroEric L. Nuermberger1Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA2TB Alliance: Global Alliance for Tuberculosis Drug Development, New York, New York
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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A population pharmacokinetic model for posaconazole intravenous solution and oral powder for suspension formulations in pediatric patients with neutropenia Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-20 Gregory WinchellRik de GreefAziz OuerdaniFloris FauchetRebecca E. WrishkoEric ManginChristopher BrunoHetty Waskin1Certara USA, Inc., Princeton, New Jersey, USA2Certara France, Paris, France3Merck & Co., Inc., Rahway, New Jersey, USA, Damian J. Krysan
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Interspecies variability in protein binding of antibiotics basis for translational PK/PD studies—a case study using cefazolin Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-20 Hifza AhmedMichaela BöhmdorferSabine EberlWalter JägerMarkus Zeitlinger1Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria2Department of Clinical Pharmacy, University of Vienna, Vienna, Austria, James E. Leggett
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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A multi-species outbreak of VIM-producing carbapenem-resistant bacteria in a burn unit and subsequent investigation of rapid development of cefiderocol resistance Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-20 Jeffrey A. FreibergLili TaoCarmila ManuelLaura A. MikeGeorge E. NelsonBryan D. HarrisAmy J. MathersThomas R. TalbotEric P. SkaarRomney M. Humphries1Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA2Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA3Department
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-20 Jessica R. TaitDovile AndersonRoger L. NationDarren J. CreekCornelia B. Landersdorfer1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia, James E. Leggett
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Phage-antibiotic synergy against daptomycin-nonsusceptible MRSA in an ex vivo simulated endocardial pharmacokinetic/pharmacodynamic model Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-20 Ashlan J. Kunz CoyneCallan BleickKyle StamperRazieh KebriaeiArnold S. BayerSusan M. LehmanMichael J. Rybak1Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA2The Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA3The Lundquist Institution
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Antibacterial activity of ibezapolstat against antimicrobial-resistant clinical strains of Clostridioides difficile Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-16 Eugénie BassèresTaryn A. EubankKhurshida BegumM. Jahangir AlamJinhee JoThanh M. LeChris K. LancasterAnne J. Gonzales-LunaKevin W. Garey1Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA, Ryan K. Shields
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Staphylococcus aureus AbcA transporter enhances persister formation under β-lactam exposure Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-16 Q. C. Truong-BolducY. WangR. Ferrer-EspadaJ. L. ReedyA. T. MartensY. GoulevJ. PaulssonJ. M. VyasD. C. Hooper1Infectious Diseases Division and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA2Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA, Helen Boucher
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Efficacy of therapeutically administered gepotidacin in a rabbit model of inhalational anthrax Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-15 Jamese J. HilliardCharles JakielaszekFrank ManninoMohammad HossainLian QianCindy FishmanSamandra DemonsJeremy HershfieldCarl SofflerRiccardo RussoLisa HenningJoseph NovakKaren O'Dwyer1GSK, Collegeville, Pennsylvania, USA2US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA3Rutgers University School of Medicine, Newark, New Jersey, USA4Battelle Biomedical Research Center
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Erratum for Estabrook et al., “Epidemiology of Resistance Determinants Identified in Meropenem-Nonsusceptible Enterobacterales Collected as Part of a Global Surveillance Study, 2018 to 2019” Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-13 Mark EstabrookAstrid MuyldermansDaniel SahmDenis PierardGregory StoneEric Utt
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Effect of the aggregated protein dye YAT2150 on Leishmania parasite viability Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-13 Lucía Román-ÁlamoYunuen Avalos-PadillaInés Bouzón-ArnáizValentín IglesiasJorge Fernández-LajoJuan M. MonteiroLuis RivasRoser FisaCristina RieraDavid AndreuCarlos Pintado-GrimaSalvador VenturaElsa M. ArceDiego Muñoz-TorreroXavier Fernàndez-Busquets1Barcelona Institute for Global Health (ISGlobal), Hospital Clínic-Universitat de Barcelona, Barcelona, Spain2Institute for Bioengineering of Catalonia (IBEC)
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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C-terminal deletion of RelA protein is suggested as a possible cause of infective endocarditis recurrence with Enterococcus faecium Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-13 José Manuel Ortiz de la RosaGuillermo Martín-GutiérrezCarlos S. Casimiro-SoriguerMaría Adelina Gimeno-GascónJosé Miguel CisnerosArístides de AlarcónJosé Antonio Lepe1Clinical Unit of Infectious Diseases, Microbiology and Parasitology, University Hospital Virgen del Rocío, Seville, Spain2Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Identification of epidermal growth factor receptor-tyrosine kinase inhibitor targeting the VP1 pocket of human rhinovirus Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-13 Masum MiahAndrew M. DavisCharles HannounJoanna S. SaidMartina FitzekMarian PrestonDave SmithColores UwamariyaAmbjörn KärmanderThomas LundbäckTomas BergströmEdward Trybala1Department of Infectious Disease, Section for Clinical Virology, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden2Discovery Sciences, BioPharmaceutical R&D, AstraZeneca, Mölndal, Sweden3Discovery Sciences, BioPharmaceutical
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Sensitizing methicillin-resistant Staphylococcus aureus (MRSA) to cefuroxime: the synergic effect of bicarbonate and the wall teichoic acid inhibitor ticlopidine Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-13 Selvi C. ErsoyRichard A. ProctorWarren E. RoseWessam AbdelhadySook-Ha FanSabrina L. MadrigalAhmed M. ElsayedHenry F. ChambersRita G. SobralArnold S. Bayer1The Lundquist Institute for Biomedical Innovations at Harbor-UCLA Medical Center, Torrance, California, USA2Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA3Department of Medical Microbiology
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Inhibition of AMPK activation in Echinococcus granulosus sensu stricto limits the parasite’s glucose metabolism and survival Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-13 Mingzhi YanHui LiuYansen SuXiaojuan BiNing YangRenyong LinGuodong Lü1State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China2Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China3Anhui University
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Removal of common antimicrobial agents by sustained low-efficiency dialysis Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-13 Joanna Q. HudsonMadelyn N. HilgersElvira O. Gosmanova1Department of Clinical Pharmacy and Translational Science, The University of Tennessee Health Science Center, Memphis, Tennessee, USA2Department of Medicine (Nephrology), The University of Tennessee Health Science Center, Memphis, Tennessee, USA, James E. Leggett
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Mavintramycin A is a promising antibiotic for treating Mycobacterium avium complex infectious disease Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-09 Kanji HosodaNobuhiro KoyamaSatoru ShigenoTomoyasu NishimuraNaoki HasegawaAkihiko KanamotoTaichi OhshiroHiroshi Tomoda1Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan2Drug Discovery Laboratory, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan3Medicinal Research Laboratories, School of Pharmacy, Kitasato University
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Biochemical characterization of the L1-like metallo-β-lactamase from Stenotrophomonas lactitubi Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-08 Kageto YamadaYoshikazu IshiiKazuhiro Tateda1Department of Microbiology and Infectious Disease, Toho University School of Medicine, Tokyo, Japan, Alessandra Carattoli
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-08 Jieqiang ZhouYuli QianYinzhi LangYongzhen ZhangXun TaoBartolome MoyaAlaa R. M. SayedCornelia B. LandersdorferEunjeong ShinCarolin WerkmanNicholas M. SmithTae Hwan KimMonika KumaraswamyBeom Soo ShinBrian T. TsujiRobert A. BonomoRichard E. LeeJürgen B. Bulitta1Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA2Servicio de Microbiología
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting “block and lock” treatment strategies Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-06 Riley M. HorvathZabrina L. BrummeIvan Sadowski1Department of Biochemistry and Molecular Biology Molecular Epigenetics Group, LSI, University of British Columbia, Vancouver, British Columbia, Canada2Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada3British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada, Miguel Angel Martinez
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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In vivo pharmacodynamic characterization of a next-generation polyene, SF001, in the invasive pulmonary aspergillosis mouse model Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-06 Alexander J. LepakBrian VanScoyChris RubinoPaul G. AmbroseDavid R. Andes1Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA2Institute for Clinical Pharmacodynamics, Schenectady, New York, USA3Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA4William S. Middleton Memorial VA Hospital, Madison
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-06 Sibylle HaidAlina MatthaeiMelina WinklerSvenja M. SakeAntonia P. GuneschVanessa MilkeNatalie M. KöhlerJessica RückertGabrielle VieyresDavid KühlTu-Trinh NguyenMatthias GöhlLisa LasswitzFrancisco J. Zapatero-BelinchónGraham BrogdenGisa GeroldBettina WiegmannUrsula BilitewskiRichard J. P. BrownMark BrönstrupThomas F. SchulzThomas Pietschmann1Institute for Experimental Virology, Twincore - Centre for
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Simulated drug disposition in critically ill patients to evaluate effective PK/PD targets for combating Pseudomonas aeruginosa resistance to meropenem Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-06 Xiaonan ZhangYan WangSanwang LiFeifan XieHanxi Yi1Division of Biopharmaceutics and Pharmacokinetics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China2Yueyang Inspection and Testing Center, Yueyang, China3Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China4Department of Pathology, School of Basic Medical Science, Central
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Limitations of antifungal prophylaxis in preventing invasive Candida surgical site infections after liver transplant surgery Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-02-01 M. CarugatiS. ArifM. E. YarringtonL. Y. KingM. HarrisK. EvansA. S. BarbasD. L. SudanJ. R. PerfectR. A. MillerB. D. Alexander1Department of Medicine, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA2Department of Medicine, Division of Gastroenterology, Duke University, Durham, North Carolina, USA3Department of Pharmacy, Duke University, Durham, North Carolina, USA4Department
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Manidipine is not a potential inhibitor against SARS-CoV-2 main protease Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-01-31 Rui ZhangJiahao ZhouHaohao YanXiaoping LiuChao ShangYunyu Chen1Institute for Drug Screening and Evaluation, Wannan Medical College, Wuhu, China2Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China, Miguel Angel Martinez
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-01-30 Alina IovlevaChristi L. McElhenyErin L. FowlerEric CoberErica S. HercCesar A. AriasCarol HillKeri BaumVance G. Fowler, Jr.Henry F. ChambersKerryl E. Greenwood-QuaintanceRobin PatelDavid van DuinRobert A. BonomoYohei Doi1Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, USA3Division
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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A single locus determines praziquantel response in Schistosoma mansoni Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-01-30 Frédéric D. ChevalierWinka Le Clec’hMatthew BerrimanTimothy J.C. Anderson1Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, USA2School of Infection and Immunity, University of Glasgow, Glasgow, UK3Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA, Audrey Odom John
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-01-30 Yuanyuan JiaoJun YanDhruvitkumar S. SutariaPeggy LuMichael VicchiarelliZeferino ReynaJuan Ruiz-DelgadoElizabeth BurkEugene MoonNirav R. ShahBrad SpellbergRobert A. BonomoGeorge L. DrusanoArnold LouieBrian M. LunaJürgen B. Bulitta1Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA2Department of Molecular Microbiology and Immunology
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faecium Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-01-30 Dierdre B. Axell-HouseShelby R. SimarDiana PanessoSandra RinconWilliam R. MillerAyesha KhanOrville A. PembertonLizbet ValdezApril H. NguyenKara S. HoodKirsten RydellAndrea M. DeTranaltesMary N. JonesRachel AtterstromJinnethe ReyesPranoti V. SahasrabhojaneGeehan SuleymanMarcus ZervosSamuel A. ShelburneKavindra V. SinghYousif ShamooBlake M. HansonTruc T. TranCesar A. Arias1Division of Infectious Diseases
Antimicrobial Agents and Chemotherapy, Ahead of Print.
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Transposition mechanism of ISApl1—the determinant of colistin resistance dissemination Antimicrob. Agents Chemother. (IF 4.9) Pub Date : 2024-01-30 Wei LiZhien HeWei DiWeifeng XuYujie LiBaolin Sun1Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China, Anne-Catrin Uhlemann
Antimicrobial Agents and Chemotherapy, Ahead of Print.