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Quantitative Analysis of Flavonoids in Glycyrrhiza uralensis Fisch by 1H-qNMR J. Anal. Methods Chem. (IF 1.878) Pub Date : 2021-01-18 Ping Yu; Qian Li; Yanmei Feng; Yuying Chen; Sinan Ma; Xiaoqin Ding
Objective. To establish a method for simultaneous determination of liquiritin, liquiritigenin, and isoliquiritinin glycyrrhizin using hydrogen nuclear magnetic resonance quantitative technology (1H-qNMR). Methodology. Deuterated dimethyl sulfoxide was used as the solvent, and dichloromethane was used as the internal standard. The probe temperature was 298.0 K, the pulse sequence was Zg30, the number
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Quantitation of Apremilast in Beagle Dogs Plasma by UPLC-MS-MS and Its Application to Pharmacokinetic Studies J. Anal. Methods Chem. (IF 1.878) Pub Date : 2021-01-16 Wei Xiong; Ling Wang; Haiyan Zhang; Xiaoqiu Tao; Xuehua Jiang; Zejuan Liu; Jiajia Zhao; Wenwen Xu
A sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method for the determination of apremilast in beagle dog plasma has been developed and successfully validated in the current study. Clopidogrel was employed as an internal standard (IS), and liquid-liquid extraction by tert-butylmethyl ether was used for sample preparation. Chromatographic separation
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Rapid Screening and Quantitative Analysis of 74 Pesticide Residues in Herb by Retention Index Combined with GC-QQQ-MS/MS J. Anal. Methods Chem. (IF 1.878) Pub Date : 2021-01-16 Peng Tan; Li Xu; Xi-Chuan Wei; Hao-Zhou Huang; Ding-Kun Zhang; Chen-Juan Zeng; Fu-Neng Geng; Xiao-Ming Bao; Hua Hua; Jun-Ning Zhao
In this research, a very practical QuEChERS-GC-MS/MS analytical approach for 74 pesticide residues in herb based on retention index was established. This novel analytical approach has two important technical advantages. One advantage is to quickly screen pesticide compounds in herbs without having to use a large number of pesticide standard substances at the beginning of the experiment. The other advantage
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Rapid Geographical Origin Identification and Quality Assessment of Angelicae Sinensis Radix by FT-NIR Spectroscopy J. Anal. Methods Chem. (IF 1.878) Pub Date : 2021-01-12 Zhen-yu Zhang; Ying-jun Wang; Hui Yan; Xiang-wei Chang; Gui-sheng Zhou; Lei Zhu; Pei Liu; Sheng Guo; Tina T. X. Dong; Jin-ao Duan
Angelicae Sinensis Radix is a widely used traditional Chinese medicine and spice in China. The purpose of this study was to develop a methodology for geographical classification of Angelicae Sinensis Radix and determine the contents of ferulic acid and Z-ligustilide in the samples using near-infrared spectroscopy. A qualitative model was established to identify the geographical origin of Angelicae
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Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater J. Anal. Methods Chem. (IF 1.878) Pub Date : 2021-01-09 Bui Van Hoi; Cam-Tu Vu; Lan-Anh Phung-Thi; Thao Thi Nguyen; Phuong Thanh Nguyen; Huong Mai; Phuong-Thu Le; Thanh-Hien Nguyen; Dao Thanh Duong; Hue Nguyen Thi; Dung Le-Van; Dinh Binh Chu
In this study, an analytical method for the simultaneous determination of 7 major pharmaceutical residues in Vietnam, namely, carbamazepine, ciprofloxacin, ofloxacin, ketoprofen, paracetamol, sulfamethoxazole, and trimethoprim, in surface water and hospital wastewater has been developed. The method includes enrichment and clean-up steps by solid phase extraction using mix-mode cation exchange, followed
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Spectrophotometric Determination of p-Nitrophenol under ENP Interference J. Anal. Methods Chem. (IF 1.878) Pub Date : 2021-01-07 Hui Xia; Wenjing Zhang; Zhijie Yang; Zhenxue Dai; Yuesuo Yang
Engineered nanoparticles (ENPs) have been widely developed in various fields in recent years, resulting in an increasing occurrence of nanoparticles in the natural environment. However, the tiny substances have created unexpected confusion in environmental sample testing due to the negative nanoeffect of ENPs. In this paper, a novel technique of spectrophotometric determination of p-nitrophenol (PNP)
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Development and Validation of a Complexometric and Potentiometric Titration Method for the Quantitative Determination of Zinc Pyrithione in Shampoo J. Anal. Methods Chem. (IF 1.878) Pub Date : 2021-01-06 Greciel E. Egurrola; Angela P. Mazabel; Johnbrynner García
Most of the pharmaceutical and cosmetic products used for the treatment of dandruff have zinc pyrithione as an active ingredient; therefore; quantifying this component becomes necessary. The purpose of this study was the validation of two simple and fast methodologies in the quantification of zinc pyrithione for shampoo quality control to guarantee consumer safety. The first method comprised a manual
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Determination of Organophosphorus Esters in Fall Protection Equipment by Accelerated Solvent Extraction and Solid-Phase Extraction Coupled with LC-MS/MS Detection J. Anal. Methods Chem. (IF 1.878) Pub Date : 2021-01-05 Haihong Li; Mingli Ye; Fangfang Wu; Xuyang Zhao; Lifeng Wang; Yili Wei; Shengyi Xie; Hairong Cui
An analysis method was established to determine 14 organophosphorus ester (OPE) flame retardants in fall protection equipment by combining accelerated solvent extraction (ASE) and solid-phase extraction (SPE) with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The ASE parameters were optimized as follows: static extraction with acetonitrile at 80°C for 5 min for two cycles
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Kinetics of Organic Biodegradation and Biogas Production in the Pilot-Scale Moving Bed Biofilm Reactor (MBBR) for Piggery Wastewater Treatment J. Anal. Methods Chem. (IF 1.878) Pub Date : 2021-01-05 Thi Ha Nguyen; Manh Khai Nguyen; Thi Hoang Oanh Le; Thanh Tu Bui; Trong Hieu Nguyen; Truong Quan Nguyen; Anh van Ngo
In this research, the kinetics of COD biodegradation and biogas production in a moving bed biofilm reactor (MBBR) at pilot scale (10 m3) for piggery wastewater treatment were investigated. Polyethylene (PE) was used as a carrying material, with organic loading rates (OLRs) of 10, 15, and 18 kgCOD/m3 day in accordance to hydraulic retention times (HRTs) of 0.56, 0.37, and 0.3 day. The results showed
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Improvement of Hydrophilicity for Polyamide Composite Membrane by Incorporation of Graphene Oxide-Titanium Dioxide Nanoparticles J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-30 Thu Hong Anh Ngo; Chau Thi Minh Nguyen; Khai Dinh Do; Quan Xuan Duong; Nghia Hieu Tran; Hoan Thi Vuong Nguyen; Dung Thi Tran
In this work, the polyamide (PA) membrane surface has been modified by coating of nanomaterials including graphene oxide (GO) and titanium dioxide (TiO2) to enhance membrane separation and antifouling properties. The influence of surface modification conditions on membrane characteristics has been investigated and compared with a base membrane. Membrane surface properties were determined through scanning
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Development of a Simple and Powerful Analytical Method for Formaldehyde Detection and Quantitation in Blood Samples J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-30 Yong-Hyun Kim; Jeongsik Park
Human beings are easily exposed to formaldehyde (FA) in a living environment. Entry of FA into the human body can have adverse effects on human health, depending on the FA concentration. Thus, a quantitative analysis of FA in blood is necessary in order to estimate its effect on the human body. In this study, a simple and rapid analytical method for the quantitation of FA in blood was developed. The
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An Electrochemical Sensor Based on Gold Nanodendrite/Surfactant Modified Electrode for Bisphenol A Detection J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-29 Nguyen Thi Lien; Le Quoc Hung; Nguyen Tien Hoang; Vu Thi Thu; Dau Thi Ngoc Nga; Pham Thi Hai Yen; Pham Hong Phong; Vu Thi Thu Ha
In the present work, we reported the simple way to fabricate an electrochemical sensing platform to detect Bisphenol A (BPA) using galvanostatic deposition of Au on a glassy carbon electrode covered by cetyltrimethylammonium bromide (CTAB). This material (CTAB) enhances the sensitivity of electrochemical sensors with respect to the detection of BPA. The electrochemical response of the modified GCE
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Isolation and Identification of Chemical Constituents from Zhideke Granules by Ultra-Performance Liquid Chromatography Coupled with Mass Spectrometry J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-29 Guangqiang Huang; Jie Liang; Xiaosi Chen; Jing Lin; Jinyu Wei; Dongfang Huang; Yushan Zhou; Zhengyi Sun; Lichun Zhao
Chemical constituents from Zhideke granules were rapidly isolated and identified by ultra-performance liquid chromatography (UPLC) coupled with hybrid quadrupole-orbitrap mass spectrometry (MS) in positive and negative ion modes using both full scan and two-stage threshold-triggered mass modes. The secondary fragment ion information of the target compound was selected and compared with the compound
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Analysis of Antioxidant Capacity of Chromones in Saposhnikoviae Radix Obtained by Ultrasonic-Assisted Deep Eutectic Solvents Extraction J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-28 Xianwen Yue; Fangfei Xu; Peng Lv; Huailei Yang; Huiwei Bao; Yang Xu
In this paper, ultrasonic-assisted deep eutectic solvent (DES) extraction was applied to the acquisition of chromones (cimicifugin, prim-o-glucosylcimifugin, and 5-o-methylvisamminoside) from Saposhnikoviae radix (SR). The extraction effects of 11 prepared DESs were screened taking contents of chromones as indexes. Furthermore, the optimum extraction conditions were confirmed using a single-factor
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Development of Fast Analytical Method for the Detection and Quantification of Honey Adulteration Using Vibrational Spectroscopy and Chemometrics Tools J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-23 Omar Elhamdaoui; Aimen El Orche; Amine Cheikh; Brahim Mojemmi; Rachid Nejjari; Mustapha Bouatia
In this study, the Fourier transform mid-infrared (FT-MIR) spectroscopy technique combined with chemometrics methods was used to monitor adulteration of honey with sugar syrup. Spectral data were recorded from a wavenumber region of 4000–600 cm−1, with a spectral resolution of 4 cm−1. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used for qualitative analysis to discriminate
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Masking Ability of Various Metal Complexing Ligands at 1.0 mM Concentrations on the Potentiometric Determination of Fluoride in Aqueous Samples J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-18 Sakuni M. De Silva; Samitha Deraniyagala; Janitha K. Walpita; Indira Jayaweera; Saranga Diyabalanage; Asitha T. Cooray
Fluoride is a common anion present in natural waters. Among many analytical methods used for the quantification of fluoride in natural waters, potentiometric analysis is one of the most widely used methods because of minimum interferences from other ions commonly present in natural waters. The potentiometric analysis requires the use of ionic strength adjusting buffer abbreviated as TISAB to obtain
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Comparison of DMA-80 and ICP-MS Combined with Closed-Vessel Microwave Digestion for the Determination of Mercury in Coal J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-18 Siyu Zhang; Mingxuan Zhou
As one of the most widely used techniques for concentration determination of trace elements in coal, inductively coupled plasma mass spectrometry (ICP-MS) has also been used in several studies for the determination of mercury concentration in coal. ICP-MS after closed-vessel microwave digestion and a Milestone DMA-80 are employed in this study to determine the mercury concentration in coal. Three NIST
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Development of a UPLC-MS/MS Method for the Quantification of VS-5584 and Its Application in Pharmacokinetic Studies in Rats J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-17 Chunling Zhou; Xiaoxin Li; Aiping He; Tianzhu Liu; Jinmiao Tian; Meihua Jiang; Lina Fang
VS-5584 is a small-molecular compound that showed equivalent activity against mTOR and all class I PI3K isoforms and demonstrated preclinical activity in diverse cancer cell lines and xenograft tumor model, and rational combination of VS-5584 and other target therapies achieved promising outcomes in oncology. In the present study, we established and validated a simple and sensitive UPLC-MS/MS method
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Instrumental Techniques for Characterization of Molybdenum Disulphide Nanostructures J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-16 Kabelo E. Ramohlola; Emmanuel I. Iwuoha; Mpitloane J. Hato; Kwena D. Modibane
The excellent chemical and physical properties of materials (nanomaterials) with dimensions of less than 100 nm (nanometers) resulted in researchers and industrialists to have great interest in their discovery and applications in various systems/applications. As their sizes are reduced to nanoscale, these nanomaterials tend to possess exceptional properties differing from those of their bulk counterparts;
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A Validated Volumetric Absorptive Microsampling-Liquid Chromatography Tandem Mass Spectrometry Method to Quantify Doxycycline Levels in Urine: An Application to Monitor the Malaria Chemoprophylaxis Compliance J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-15 Mylène Penot; Cyril Linard; Nicolas Taudon
Because of logistics and cost constraints, monitoring of the compliance to antimalarial chemoprophylaxis by the quantitation of drugs in biological samples is not a simple operation on the field. Indeed, analytical devices are fragile to transport and must be used in a perfectly controlled environment. This is also the case for reagents and supplies, and the waste management is constraining. Thus,
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Evaluation of Reducing Ability and Antioxidant Activity of Fruit Pomace Extracts by Spectrophotometric and Electrochemical Methods J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-14 Georgii S. Vasyliev; Victoria I. Vorobyova; Olga V. Linyucheva
The component profiles of apricot, grape, and black currant pomace extracts have been analyzed using HPLC coupled to diode-array detection and tandem mass spectrometry (HPLC-DAD-MS). The predominant components in grape, apricot, and black currant pomace extracts were phenolic acids and flavonols. The redox behavior of apricot, black currant, and grape pomace water extracts was evaluated by means of
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Removal of Tetracycline from Aqueous Solution Using Nanocomposite Based on Polyanion-Modified Laterite Material J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-11 Thi Hau Vu; Thi Mai Viet Ngo; Thi Tu Anh Duong; Thi Hien Lan Nguyen; Xuan Truong Mai; Thi Hong Nguyet Pham; Thi Phuong Le; Thi Hue Tran
This work investigated the removal of antibiotic tetracycline (TC) from wastewater using nanocomposite material based on laterite modified with polyanion, polystyrene sulfonate (PSS). The effective factors influenced on the TC removal using nanocomposite PSS-modified laterite (NCPML) were optimized and found to be pH 4, solid-liquid ratio 5 mg/mL, and contact time 180 min. The highest removal of TC
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A Chemiluminescent Immunoassay for Osteocalcin in Human Serum and a Solution to the “Hook Effect” J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-09 Shuang Han; Yifeng Xue; Junlan Zhang; Jianrong Huang; Xiuxia Liu; Yankun Yang; Zhonghu Bai; Chunxin Wang
A chemiluminescent immunoassay for human serum osteocalcin, or bone Gla protein, was established using a double-antibody sandwich model. Examination of the hook effect revealed that it was significantly reduced, and no hook effect was observed at an osteocalcin concentration of 4000 ng/mL. The established method showed good analytical performance and thermal stability. The limit of detection was 0
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Adsorptive Removal of Rhodamine B Using Novel Adsorbent-Based Surfactant-Modified Alpha Alumina Nanoparticles J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-09 Thi Hai Yen Doan; Thi Phuong Minh Chu; Thi Diu Dinh; Thi Hang Nguyen; Thi Cam Tu Vo; Nhat Minh Nguyen; Bao Huy Nguyen; The An Nguyen; Tien Duc Pham
The objective of the present study is to investigate removal of cationic dye, rhodamine B (RhB), in water environment using a high-performance absorbent based on metal oxide nanomaterials toward green chemistry. The adsorption of sodium dodecyl sulfate (SDS) onto synthesized alpha alumina (α-Al2O3) material (M0) at different ionic strengths under low pH was studied to fabricate a new adsorbent as SDS-modified
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Assessment of the Oxidative Desulfurization of Middle Distillate Surrogate Fuels with Spectroscopic Techniques J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-09 Eleni Syntyhaki; Anastasia Detsi; Dimitrios Karonis
The oxidative desulfurization of five (5) model sulfur compounds and eleven (11) surrogate blends was investigated using the hydrogen peroxide (H2O2)-acetic acid (CH3COOH) system. Consequently, extractive desulfurization was carried out using conventional solvents. The model sulfur compounds, as well as the solvent, are present in petroleum middle distillates. The selection of the compounds was made
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Spectrum-Effect Relationships of Flavonoids in Glycyrrhiza uralensis Fisch. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-12-03 Tingting Li; Shiyao Hua; Jiahua Ma; Lin Dong; Fang Xu; Xueyan Fu
Glycyrrhiza uralensis Fisch. is used in large quantities in traditional Chinese medicine. It contains flavonoids, saponins, and polysaccharides, with flavonoids being the main active ingredients. In this study, flavonoids were isolated from the roots of Glycyrrhiza uralensis Fisch. grown in 21 areas in China by water extraction, alcohol precipitation, polyamide resin separation, and other methods.
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Application of Near-Infrared Spectroscopy Analysis Technology to Total Nucleosides Quality Control in the Fermented Cordyceps Powder Production Process J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-11-28 Tiannv Shi; Yongmei Guan; Lihua Chen; Shiyu Huang; Weifeng Zhu; Chen Jin
Product quality control is a prerequisite for ensuring safety, effectiveness, and stability. However, because of the different strain species and fermentation processes, there was a significant difference in quality. As a result, they should be clearly distinguished in clinical use. Among them, the fermentation process is critical to achieving consistent product quality. This study aims to introduce
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Nondestructive Testing for Wheat Quality with Sensor Technology Based on Big Data J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-11-20 Yan-Ge Tian; Zheng-Nan Zhang; Shuang-Qi Tian
Nondestructive testing with sensor technology is one of the fastest growing and most promising wheat quality information analysis technologies. Nondestructive testing with sensor technology benefits from the latest achievement of many disciplines such as computer, optics, mathematics, chemistry, and chemometrics. It has the advantages of simplicity, speed, low cost, no pollution, and no contact. It
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Rapid Analysis of Aristolochic Acid Analogues in Traditional Chinese Patent Medicine by LC-MS/MS J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-11-19 Jing Liu; Yang Liu; Yingxue Wu; Zhong Dai; Shuangcheng Ma
Aristolochic acids have been demonstrated to have renal toxicity, cause carcinogenesis, and may cause gene mutations. A series of risk control measurements have been adopted worldwide since 1990s. Some varieties of traditional Chinese medicine with high content of aristolochic acids have been banned in China. However, some species containing aristolochic acids in microscale are still in use. In recent
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Estimation of the Content of Selected Active Substances in Primary and Secondary Herbal Brews by UV-VIS and GC-MS Spectroscopic Analyses J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-11-12 Jakub Wyrostek; Radosław Kowalski; Urszula Pankiewicz; Ewa Solarska
Primary and secondary herbal brews were tested for the content of polyphenolic compounds, flavonoids, and essential oil. The brewing process was carried out at an initial temperature of 95°C and different time parameters (5, 10, 15, and 30 min). A secondary brewing was also carried out to estimate the reuse of the herbal material. The highest content of polyphenol compounds and flavonoids was determined
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Colorimetric Detection of Class A Soybean Saponins by G-Quadruplex-Based Hybridization Chain Reaction J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-11-05 Congcong Yin; Qiaoling Zhao; Aiqin Yue; Weijun Du; Dingbin Liu; Jinzhong Zhao; Yongpo Zhang; Min Wang
Soybean saponin is one of the important secondary metabolites in seeds, which has various beneficial physiological functions to human health. GmSg-1 gene is the key enzyme gene for synthesizing class A saponins. It is of great significance to realize the visual and rapid detection of class A saponins at the genetic level. The hybridization chain reaction (HCR) was employed to the visual detection of
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Studies on Dissipations and Residues of Indoxacarb under Different Field and Environmental Conditions J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-11-04 Ying-Hong Li; Xiang-Yun Wang; Wei Hua; Hu Zhang
Indoxacarb is a broad-spectrum insecticide and widely used in agriculture. The dissipations and residues of indoxacarb were researched at three different field sites in Beijing, Hunan, and Zhejiang provinces in China. Analytical methods for determining the residue of indoxacarb in paddy water, paddy soil, rice straw, rice hull, and brown rice were described. Indoxacarb residues were extracted from
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Near-Infrared Spectroscopy as a Process Analytical Technology Tool for Monitoring the Steaming Process of Gastrodiae rhizoma with Multiparameters and Chemometrics J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-11-04 Yamin Zuo; Jing Yang; Chen Li; Xuehua Deng; Shengsheng Zhang; Qing Wu
Steaming is a vital unit operation in traditional Chinese medicine (TCM), which greatly affects the active ingredients and the pharmacological efficacy of the products. Near-infrared (NIR) spectroscopy has already been widely used as a strong process analytical technology (PAT) tool. In this study, the potential usage of NIR spectroscopy to monitor the steaming process of Gastrodiae rhizoma was explored
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LC-MS/MS Method for Rapid Quantification of Progesterone in Rabbit Plasma and Its Application in a Pharmacokinetic Study of the Transdermal Formulation J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-10-30 Cao-Son Tran; Quang-Dong Bui; Ngoc-Tho Thi Nguyen; Minh-Hanh Dao; Thach-Tung Nguyen
A rapid and effective method using QuEChERS-based sample preparation procedure and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis has been developed and validated to determine progesterone in rabbit plasma. The analyte was extracted from plasma by acetonitrile with phase partitioning by a mixture of magnesium sulfate and sodium chloride. The supernatant was then directly injected
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Evaluation of Two Parts of Lithocarpus polystachyus Rehd. from Different Chinese Areas by Multicomponent Content Determination and Pattern Recognition J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-10-24 Min Wei; Yangling Tuo; Ye Zhang; Qi Deng; Cuiying Shi; Xuexian Chen; Xu Zhang
The purpose of this work is to establish a new method using high-performance liquid chromatography-diode array detection (HPLC-DAD) with chemometrics analysis to determine the content of catechin, isoquercetin, astragalin, phloridzin, trilobatin, and phloretin for one flavanol and five flavonoids, filter out the key compounds, and evaluate the quality of 26 batches of tender leaves and flower spikes
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Evaluation of Copper and Manganese Concentrations in Commercial Fruit Juices and Nectars Consumed in Brazil by GF AAS J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-10-16 Pamela S. M. Rocha; Graziela F. B. Cruz; Ricardo J. Cassella
The present work proposes a simple method for direct determination of Cu and Mn in commercial fruit juices and nectars by graphite furnace atomic absorption spectrometry (GF AAS). We analyzed samples of different flavors (orange, mango, passion fruit, peach, and grape) and brands of Brazilian commercial fruit juices and nectars. We also carried out a study to define a suitable temperature program and
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Chemical Comparison of White Ginseng before and after Extrusion by UHPLC-Q-Orbitrap-MS/MS and Multivariate Statistical Analysis J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-10-07 Yun-Long Guo; Yang Wang; Yi-Lin Zhao; Xiu-Ying Xu; Hao Zhang; Cheng-Bin Zhao; Ming-Zhu Zheng; Shu-Ying Liu; Yu-Zhu Wu; Jing-Sheng Liu
Ultrahigh-performance liquid chromatography Quadrupole-Orbitrap tandem mass spectrometry (UHPLC-Q-Orbitrap-MS/MS) was used to compare the composition of ginsenosides in white ginseng (WG) and extruded white ginseng (EWG). A total of 45 saponins, including original neutral ginsenosides, malonyl-ginsenosides, and chemical transformation of ginsenosides, were successfully identified in both WG and EWG
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A Preferable Approach for the Quality Control of Xiaoer Chiqiao Qingre Granules Based on the Combination of Chromatographic Fingerprints and Chemometrics J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-29 Tong Xu; Xiaoqi Li; Mengmeng Huang; Qi Wang; Chao Li; Gang Tian; Yan Chen
A preferable approach of a combination of a multiwavelength fusion HPLC fingerprint and chemometrics for the quality control of Xiaoer Chiqiao Qingre granules (XCQG) was established in this study. A single-wavelength HPLC fingerprint was performed to identify 18 peaks as common peaks in the beginning, and 12 of them were recognized by HPLC-Q/TOF-MS. To overcome the limitation of the single-wavelength
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Quality Assessment of Different Species and Differently Prepared Slices of Zedoray Rhizome by High-Performance Liquid Chromatography and Colorimeter with the Aid of Chemometrics J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-29 Fei Sun; Xiaolu Yang; Fei Liu; Ying Zhang; Shumei Wang; Hui Cao; Jiang Meng; Boryana M. Nikolova Damyanova
In this study, high-performance liquid chromatography (HPLC) and colorimeter were applied to evaluate the quality of different species and differently prepared slices of Zedoray Rhizome samples with the aid of chemometric tools. Fifty batches of Zedoray Rhizome samples from different species and forty-two batches of Zedoray Rhizome samples from differently prepared slices were collected. The quantitative
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Chemical Fingerprint Analysis for Discovering Markers and Identifying Saussurea involucrata by HPLC Coupled with OPLS-DA J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-19 Qingdong Ma; Xiaoxiang Chen; Ke Zhang; Dahong Yao; Lu Yang; Hangyu Wang; Santai Bulemasi; Jian Huang; Jinhui Wang
The quality control of Saussurea involucrata has been greatly improved by macroscopic and microscopic identification and chemical profiling described in Chinese Pharmacopoeia since 2005. However, these methods have their own limitations, e.g., their dependence on personal experience and expertise, and it is a huge challenge to identify closely related species that share similar or identical morphological
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Establishment of a UPLC-MS/MS Method for Studying the Effect of Salt-Processing on Tissue Distribution of Twelve Major Bioactive Components of Qing’e Pills in Rats J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-17 Jingxia Hou; Shangyang Lin; Jinlan Lu; Yu Wu; Li Wu; Zhipeng Chen; Weidong Li
Qing’e pills is clinically used for treating osteoporosis in postmenopausal women in China. Eucommiae Cortex and Psoraleae Fructus are the main herbs of Qing’e pills and are both required to be salt-processed. In order to study the influence of salt-processing on the tissue distribution of Qing’e pills, a UPLC-MS/MS method was established for studying the tissue distribution of 12 main bioactive ingredients
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Tracing the Geographical Origins of Dendrobe (Dendrobium spp.) by Near-Infrared Spectroscopy Sensor Combined with Porphyrin and Chemometrics J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-12 Chaogeng Lv; Yali He; Chuanzhi Kang; Li Zhou; Tielin Wang; Jian Yang; Lanping Guo
Dendrobe (Dendrobium spp.) is a traditional medicinal and edible food, which is rich in nutrients and contains biologically active metabolites. The quality and price of dendrobe are related to its geographical origins, and high quality dendrobe is often imitated by low quality dendrobe in the market. In this work, near-infrared (NIR) spectroscopy sensor combined with porphyrin and chemometrics was
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Magnetic Solid Phase Extraction as a Promising Technique for Fast Separation of Metallic Nanoparticles and Their Ionic Species: A Review of Recent Advances. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-11 Ingrid Hagarová
The widespread use of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) in a wide variety of industrial as well as medical sectors is indisputable. This leads to a new concern about their presence in various environmental compartments. Since their negative effect and potential toxicity impact have been confirmed, analytical chemists focus on the development of different procedures for their
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Determination of Antioxidant 264 in the Butyl Rubber Stopper and the Compatibility with Recombinant Potent Antitumor and Antivirus Protein Injection. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-09 Min Zhao,Xianhui Li,Di Zhang,Longshan Zhao
Objective. To establish a method for extraction and determination of antioxidant 264 (2,6-di-tert-butyl-4-methylphenol) in the brominated butyl rubber stopper for injection and migration study in recombinant potent antitumor and antivirus protein injection (Novaferon). Methods. Dichloromethane-ethanol was adopted as the extraction solvent during the process of reflux extraction of antioxidant 264 in
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Removal of Heavy Metal Ion Using Polymer-Functionalized Activated Carbon: Aspects of Environmental Economic and Chemistry Education. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-07 Hoang Thu Ha,Nguyen Thi Huong,Le Linh Dan,Nguyen Duy Tung,Vinh Bao Trung,Tran Dinh Minh
Numerous countries have shown signs of environmental pollution to prioritize economic growth and benefits, leading to seriously contaminated waters. This work indicated the method to synthesize a green material, which could remove contaminants to protect the natural environment. The porosity and functionality effects of amine-functionalized activated carbon (AFAC) enhanced the removal of toxic heavy
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Miniaturized Fluorimetric Method for Quantification of Zinc in Dry Dog Food. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-04 Rute C Martins,Ana M Pereira,Elisabete Matos,Luisa Barreiros,António J M Fonseca,Ana R J Cabrita,Marcela A Segundo
Zinc is an essential trace element for animals in several biological processes, particularly in energy production, and it is acquired from food ingestion. In this context, a microplate-based fluorimetric assay was developed for simple, fast, and low-cost determination of zinc in pet food using 2,2′-((4-(2,7-difluoro-3,6-dihydroxy-4aH-xanthen-9-yl)-3-methoxyphenyl)azanediyl)diacetic acid (FluoZin-1)
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Performance Optimization of Microvalves Based on a Microhole Array for Microfluidic Chips. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-09-03 Cuimin Sun,Hui You,Yang Xie,Ronald X Xu
A microfluidic chip with a microvalve based on a microhole array is proposed in this paper for the POCT of tumor marker proteins. In order to control the biochemical reaction time accurately and obtain a higher testing sensitivity, the parameters of the microhole array are optimized basing on the investigation of the effects of the variation of those parameters on the fluid rate and the residual liquid
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Quantification Analysis of 13 Organic Components and 8 Inorganic Elements in Angelica Sinensis Radix and Its Different Parts Combined with Chemical Recognition Pattern. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-31 Xi Li,Yixin Yao,Xiaoxiao Wang,Chang An,Shanshan Gao,Fangtao Xiang,Yangli Dong
Angelica Sinensis Radix (Danggui, DG) is one of the most commonly prescribed traditional Chinese medicines. The organic components include phthalides and phenolic acids. Meanwhile, inorganic elements play an important role in clinical effect. DG and its different parts have different effects. There is no relevant report on the analysis of organic compounds and inorganic elements among them. Therefore
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Rapid Assessment of Exercise State through Athlete's Urine Using Temperature-Dependent NIRS Technology. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-29 Lihe Ding,Lei-Ming Yuan,Yiye Sun,Xia Zhang,Jianpeng Li,Zou Yan
Athletes usually take nutritional supplements and perform the specialized training to improve the performance of sport. A quick assessment of their athletic status will help to understand the current physical function of athletes’ status and the effect of nutritional supplementation. Human urine, as one of the most important body indicators, is composed of many metabolites, which can provide effective
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Determination and Pharmacokinetics of Okanin in Rat Plasma by UltraHigh Performance Liquid Chromatography Coupled with Triple-Quadrupole Tandem Mass Spectrometry. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-28 Yurui Shi,Rongda Chen,Jing Xie,Li Li,Guiming Liu,Meizhu Zheng,Ning Zhang
Okanin is a major flavonoid found in Coreopsis tinctoria Nutt., arousing huge interest recently for its considerable biological characteristics including antioxidant, antineurotoxic, and antidiabetic activities. An ultrahigh performance liquid chromatography triple-quadrupole tandem mass spectrometry (UPLC-MS) was successfully used to determine okanin in rat plasma after oral administration of okanin
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Simultaneous Determination of Phenolic Acids, Anthraquinones, Flavonoids, and Triterpenes of Cynomorii Herba in Different Harvest Times by LC-MS/MS. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-26 Hua Jin,Ge Tang,Jin Li,Lin Ma,Yuhong Li,Yan-Xu Chang
A sensitive and accurate method was developed for the simultaneous determination of twelve components including phenolic acids (gallic acid, protocatechuic aldehyde, protocatechuic acid, and ferulic acid), flavonoids (catechin, epicatechin, rutin, luteolin, luteolin-7-glucoside, and epicatechin gallate), anthraquinones (emodin), and triterpenes (ursolic acid) in Cynomorii herba in different harvest
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A Low-Cost Layered Double Hydroxide (LDH) Based Amperometric Sensor for the Detection of Isoproturon in Water Using Carbon Paste Modified Electrode. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-21 Herve Leclerc Tcheumi,Aude Peggy Kameni Wendji,Ignas Kenfack Tonle,Emmanuel Ngameni
In this work, a Layered Double Hydroxide (NiAl-LDH) was obtained by coprecipitation method and used to elaborate an electrochemical sensor for the determination of isoproturon, which is a hazardous pollutant, widely used in agriculture, and its residue is distributed into aqueous environment through run-off and leaching from the soil. Various physicochemical techniques such as FT-IR spectroscopy, X-ray
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Simultaneous Determination of Five Components of Chaihu-Shugan-San in Beagle Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study after a Single Dose of Chaihu-Shugan-San. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-19 Yong-Liang Zhu,Hui-Jun Wang,Hao Xue,Yi Zhang,Qian-Shi Cheng,Ling-Yun Chen,Xiang-Jun Qiu
Chaihu-shugan-san (CHSGS) has been widely used in China to treat depression and gastrointestinal diseases for thousands of years, but little is known about its pharmacokinetic properties. The purpose of our study is to develop a reliable and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method to detect five components in beagle plasma and study their pharmacokinetic
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Simultaneous Optimization of Microwave-Assisted Extraction of Phenolic Compounds and Antioxidant Activity of Avocado (Persea americana Mill.) Seeds Using Response Surface Methodology. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-17 Alexander Weremfo,Felix Adulley,Martin Adarkwah-Yiadom
This study was designed to optimize three microwave-assisted extraction (MAE) parameters (ethanol concentration, microwave power, and extraction time) of total phenolics, total flavonoids, and antioxidant activity of avocado seeds using response surface methodology (RSM). The predicted quadratic models were highly significant () for the responses studied. The extraction of total phenolic content (TPC)
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Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve Agents. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-11 Tomas Capoun,Jana Krykorkova
General conditions and requirements for an internal standard useful in the determination of chemical warfare agents (CWAs) by the method of gas chromatography coupled with mass detection (GC/MS) were defined. The determination is based on a GC/MS analysis of a mixture of a CWA with an internal standard, conversion of the TIC chromatogram to a chromatogram extracted at a particular m/z ratio, and calculation
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Simultaneous Determination of 34 Amino Acids in Tumor Tissues from Colorectal Cancer Patients Based on the Targeted UHPLC-MS/MS Method. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-01 Yang Yang,Feng Zhang,Shouhong Gao,Zhipeng Wang,Mingming Li,Hua Wei,Renqian Zhong,Wansheng Chen
A targeted ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was established and validated for the simultaneous determination of 34 amino acids in tissue samples from colorectal cancer (CRC) patients. The chromatographic separation was achieved on an Agilent ZORBAX SB-C18 column (3.0 × 150 mm, 5 μm) with a binary gradient elution system (A, 0.02% heptafluorobutyric
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Development of a Chemiluminescence Immunoassay for Quantification of 25-Hydroxyvitamin D in Human Serum. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-08-01 Shuang Han,Wuxian Qiu,Junlan Zhang,Zhonghu Bai,Xiao Tong
In this study, a chemiluminescence immunoassay (CLIA) for human serum 25-hydroxyvitamin D (25(OH)D) was established by a competition model. In serum, more than 99% of total circulating 25(OH)D binds to protein and less than 1% of 25(OH)D is in free form (Jassil et al., 2017). Before measuring concentration of 25(OH)D in serum, a releasing procedure should be conducted. A new reagent is used to release
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Rapid and Sensitive Method for Extraction of Plicosepalus acacia with Determination of Its Main Polyphenolic Compounds Using Validated HPLC. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-07-24 Mashail N AlZain,Rashed N Herqash,Abdulaziz N Almoqbil,Omer Mohammed Almarfadi,Mansour N Ibrahim,Riaz Ullah,Omar M Noman
Matrix solid phase dispersion (MSPD) trailed by HPLC is a quick and fruitful technique utilized for fortitude of flavonoids such as Catechin, Kaempferol, Quercetin, and Rutin existing in P. acacia. The trial parameters that influenced the extraction potential (comprising the mass ratio of sample to the dispersant, nature of dispersant, and the nature of elution solvent and its volume) were examined
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Simultaneous Determination of Multiple Active Components from Bushen Pills and Application in a Pharmacokinetic Study in Rats. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-07-20 Houli Li,Benjie Wang,Guiyan Yuan,Xiaoyan Liu,Jing Huang,Lilong Xiong,Di Zhang,Weiyi Feng,Ruichen Guo
Bushen Pills (BSPs), as a traditional Chinese medicine (TCM), is widely used in clinic to enrich Yang, nourish Yin, stem essence, and strengthen kidneys. Two chromatographic methods, liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), were applied to analyze the multiple active components of BSPs in dosage form for quality evaluation and in
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Flow-Batch Sample Preparation for Fractionation of the Stress Signaling Phytohormone Salicylic Acid in Fresh Leaves. J. Anal. Methods Chem. (IF 1.878) Pub Date : 2020-07-17 Thiago L Marques,Milton K Sasaki,Lidiane C Nunes,Fábio R P Rocha
Salicylic acid (SA) is an important stress signaling phytohormone and plays an essential role in physiological processes in plants. SA fractionation has been carried out batchwise, which is not compatible with the high analytical demand in agronomical studies and increases susceptibility to analytical errors. In this context, a novel flow-batch sample preparation system for SA fractionation on fresh