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HPLC-MS/MS-Mediated Analysis of the Pharmacokinetics, Bioavailability, and Tissue Distribution of Schisandrol B in Rats Int. J. Anal. Chem. (IF 1.678) Pub Date : 2021-02-24 Dahu Liang; Zijing Wu; Yanhao Liu; Chao Li; Xianghong Li; Bin Yang; Haitang Xie; Hua Sun
Schisandrol B, a lignan isolated from dried Schisandra chinensis fruits, has been shown to exhibit hepatoprotective, cardioprotective, renoprotective, and memory-enhancing properties. This study sought to design a sensitive and efficient HPLC-MS/MS approach to measuring Schisandrol B levels in rat plasma and tissues in order to assess the pharmacokinetics, oral bioavailability, and tissue distributions
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Assessment of Some Physicochemical Parameters and Heavy Metals in Hand-Dug Well Water Samples of Kafta Humera Woreda, Tigray, Ethiopia Int. J. Anal. Chem. (IF 1.678) Pub Date : 2021-02-16 Kiros Gebremichail Gebresilasie; Goitom Gebreyohannes Berhe; Amanual Hadera Tesfay; Samuel Estifanos Gebre
Groundwater is one of the most important sources of drinking water in Kafta Humera Woreda; hence, it is important to assess the quality of these water sources. The aim of this study was to assess the levels of some physicochemical parameters and heavy metals in hand-dug well water sources of Kafta Humera Woreda. The results showed that the physicochemical concentrations of the hand-dug well water samples
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Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method Int. J. Anal. Chem. (IF 1.678) Pub Date : 2021-02-13 Nabil K. Alruwaili
The use of analytical quality by design (AQbD) approach in the optimization of the high-performance liquid chromatography (RP-HPLC) method is a novel tool. Three factors and three levels of Box–Behnken statistical design (BBD) were used for method optimization and analysis of atorvastatin. The mobile phase (acetonitrile: water), flow rate (Rt), and UV wavelength were used as independent variables.
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Total Oxidation of Isopropanol in Its Liquid Phase, at a Low Temperature in the Presence of Prepared and Characterized Zinc Oxide Int. J. Anal. Chem. (IF 1.678) Pub Date : 2021-02-09 Younes Dehmani; Abdellatif Amhoud; Sadik Abouarnadasse
The complete oxidation of isopropanol in its liquid phase at a low temperature was studied in the presence of zinc oxide (ZnO). This solid was prepared with the precipitation method. Structural analysis (infrared in Fourier transform and diffraction of X-rays) and textured (adsorption/desorption of N2) were conducted for the wurtzite structure results, an IV type isotherm with a type H3 hysteresis
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Optimization of 25% Sulfosalicylic Acid Protein-to-Creatinine Ratio for Screening of Low-Grade Proteinuria Int. J. Anal. Chem. (IF 1.678) Pub Date : 2021-01-28 Ambulugala Gamage Rajika Greshamali Jinadasa; Lanka Acharige Shalka Madushan Srimantha; Indika Deepani Siriwardhana; Kalani Buddika Gunawardana; Anoja Priyadarshani Attanayake
Proteinuria is an important prognostic marker in the diagnosis and management of kidney diseases. Sulfosalicylic acid method (SSA) is a simple, low cost, qualitative test, widely used to assess proteinuria. The aim of this study was to optimize SSA test as a quantitative screening tool to assess proteinuria at lower excretory levels which would facilitate the screening and early diagnosis of renal
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Point-of-Care Diagnoses and Assays Based on Lateral Flow Test Int. J. Anal. Chem. (IF 1.678) Pub Date : 2021-01-20 Miroslav Pohanka
Analytical devices for point-of-care diagnoses are highly desired and would improve quality of life when first diagnoses are made early and pathologies are recognized soon. Lateral flow tests (LFTs) are such tools that can be easily performed without specific equipment, skills, or experiences. This review is focused on the use of LFT in point-of-care diagnoses. The principle of the assay is explained
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Determination and Pharmacokinetics of Omeprazole Enantiomers in Human Plasma and Oral Fluid Utilizing Microextraction by Packed Sorbent and Liquid Chromatography-Tandem Mass Spectrometry Int. J. Anal. Chem. (IF 1.678) Pub Date : 2021-01-19 Hytham Ahmed; Abdel-Aziz Wahbi; Hatem Elmongy; Ahmad Amini; Hirsh Koyi; Eva Branden; Mohamed Abdel-Rehim
In the present work, the determination of omeprazole (OME) enantiomers in oral fluid and plasma samples was carried out utilizing microextraction by packed sorbent (MEPS) and liquid chromatography-tandem mass spectrometry. A chiral column with cellulose-SB phase was used for the first time for enantiomeric separation of OME with an isocratic elution system using 0.2% ammonium hydroxide in hexane-ethanol
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Computer-Aided Rapid Establishment of Fingerprint of Xiaojin Capsule by HPLC Int. J. Anal. Chem. (IF 1.678) Pub Date : 2021-01-16 Hui Jiang; Yuansheng Xiao; Xingya Xue; Hongli Jin; Yang Xiang; Yanfang Liu; Gaowa Jin
Traditional Chinese medicine (TCM) formulas have a significant clinical efficacy, and the fingerprint technology has been widely accepted to fully reveal the quality of TCM. Whereas, it is a great challenge to establish the fingerprint chromatogram which can fully reflect every single herb material in a short time. In this study, we used Xiaojin capsule (XJC) as a case and developed a rapid fingerprint
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Establishment and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Tigecycline in Critically Ill Patients Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-12-29 Fen Yao; Yifan Wang; Yating Hou; Xipei Wang; Jinhua Lan; Zheng Wu; Yirong Wang; Chunbo Chen
Utilizing tigecycline-d9 as an internal standard (IS), we establish and validate a simple, effective, and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative measurement of tigecycline (TGC) in patient plasma. Acetonitrile was used as a precipitant to process plasma samples by a protein precipitation method. The analyte and IS were separated on an HSS T3 (2.1 × 100 mm
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An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-12-29 Zhenzhen Ying; Jingyao Wei; Ruijuan Liu; Fang Zhao; Yifang Yu; Xin Tian
Osimertinib is a novel oral, potent, and irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for treatment of advanced T790M mutation-positive advanced non-small cell lung cancer, which is commonly combined with ginsenoside Rg3 in clinic to enhance the efficacy and minimize adverse reactions. In the present study, a highly sensitive UPLC-MS/MS method was established and
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Low-Vacuum Quadrupole Mass Filter Using a Drift Gas Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-12-29 Peihe Jiang; Zhanfeng Zhao
Performing mass spectrometry in a low-vacuum environment can markedly reduce the cost, size, and power consumption of instrumentation by reducing the workload of the pumping system. Under a low-vacuum environment, ions in a quadrupole mass filter do not have sufficient kinetic energy in the axial direction to reach the detector for mass analysis. To resolve this problem and develop a mass spectrometer
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Determination of Crizotinib in Mouse Tissues by LC-MS/MS and Its Application to a Tissue Distribution Study Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-12-18 Fang Zhao; Yuan Wei; Yiming Yan; Han Liu; Sitong Zhou; Bo Ren; Ruijuan Liu
Toxicity induced by crizotinib, a small-molecule tyrosine kinase inhibitor, is a significant clinical issue during treatment. A tissue distribution study is required to explore the organs affected by this molecule. In this study, a simple liquid chromatography tandem mass spectrometry method was developed and validated for the determination of crizotinib in various mouse tissues. Mouse tissue homogenates
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Simultaneous Detection of Ascorbic Acid, Dopamine, and Uric Acid Using a Novel Electrochemical Sensor Based on Palladium Nanoparticles/Reduced Graphene Oxide Nanocomposite Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-12-17 Yuyun Wei; Yangyang Liu; Zhifang Xu; Shenjun Wang; Bo Chen; Di Zhang; Yuxin Fang
A fresh strategy based on two-step electrochemical reduction for the fabrication of palladium nanoparticles/reduced oxide nanocomposite-modified glass carbon electrode (PdNPs/rGO/GCE) was established in this study. Field emission scanning electron microscopy (FESEM) images showed that spherical PdNPs were evenly distributed on the surface of rGO-modified electrode (rGO/GCE), and the introduction of
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Residues Analysis and Dissipation Dynamics of Broflanilide in Rice and Its Related Environmental Samples Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-12-15 Guai Xie; Wenwen Zhou; Mingxia Jin; Ailin Yu; Lei Rao; Horan Jia; Juan Luo; Yichang He; Baotong Li
Herein, we present a method for the quantitative analysis of broflanilide residues in water, soil, and rice samples from a paddy field in Jiangxi Province, China. The quick, easy, cheap, effective, rugged, and safe (QuEChERS) method was optimized for the extraction and purification of broflanilide residues. Residual broflanilide concentrations in different matrices were then determined by high-performance
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Systematic Analysis of the Whole-Body Tissue Distribution and Fatty Acid Compositions of Membrane Lipids in CD1 and NMRI Mice and Wistar Rats Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-11-30 Lina Xu; Maximilian V. Schmitt; Huabin Ruan; Yupei Jiao; Xueying Wang; Yusong Wang; Tao Yang; Philip Lienau; Andreas Reichel; Xiaohui Liu
Understanding the tissue distribution of phospholipids and glycerolipids in animal models enables promoting the pharmacokinetic study of drugs and related PK predictions. The measurement of lipid compositions in animal models, usually mice and rats, without a standardized approach hindered the accuracy of PBPK investigation. In this work, high resolution mass spectrometry was applied to profile the
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Quantification of DNA through the NanoDrop Spectrophotometer: Methodological Validation Using Standard Reference Material and Sprague Dawley Rat and Human DNA Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-11-29 Alejandro Monserrat García-Alegría; Iván Anduro-Corona; Cinthia Jhovanna Pérez-Martínez; María Alba Guadalupe Corella-Madueño; María Lucila Rascón-Durán; Humberto Astiazaran-Garcia
This study aimed to validate an analytical method to determine DNA concentration using standard reference material (NIST SRM 2372) and Sprague Dawley rat and human DNA. Microvolumes were used to analyse DNA samples. Linearity showed correlation coefficients higher than R ≥ 0.9950, and the precision value was ≤2% CV. Trueness based on bias and the percentage of recovery showed bias values lower than
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Removal of Fluorescein Dye from Aqueous Solutions Using Natural and Chemically Treated Pine Sawdust Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-11-26 Nada S. Al-Kadhi
The various factors affecting the removal of fluorescein dye using sawdust from aqueous solutions such as time, initial concentration, pH, and temperature were studied. The optimal conditions for removing the FD are 1 g of sawdust at pH 3 and 120 min time of contact. Dye removal dropped from 93.42% to 80.04% with natural pine sawdust (NPS) and from 96.83% to 81.51% with synthetic pine sawdust (SPS)
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A Validated Method for the Simultaneous Determination of Methamphetamine and 3,4-Methylenedioxy-N-methamphetamine in Blood-Based Liquid Chromatography-Tandem Mass Spectrometry Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-11-26 Dinh-Vu Le; Trong-Tuan Nguyen; Van-Trong Nguyen
A liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method has been validated for the simultaneous determination of methamphetamine (MA) and 3,4-methylenedioxy-N-methamphetamine (MDMA) in the blood sample. Under the optimal experimental conditions, the concentration of MA can be determined in the range from 1 µg/L to 5000 µg/L with the method detection limit (MDL) of 0.31 µg/L. The range
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Identification and Screening of Natural Neuraminidase Inhibitors from Reduning Injection via One-Step High-Performance Liquid Chromatography-Fraction Collector and UHPLC/Q-TOF-MS Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-11-17 Lijun An; Xie-An Yu; Wei Liu; Jin Li; Yan-Xu Chang
Neuraminidase plays an essential role in the spread of influenza viruses via cleaving sialic acids from the host cell receptors and virions. Neuraminidase has been regarded as an essential target for prevention and treatment of influenza infection. The one-step high-performance liquid chromatography-fraction collector (HPLC-FC) was selected to prepare fractions from Reduning (RDN) injection, while
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Determination of the Novel Insecticide Flupyradifurone and Its Two Metabolites in Traditional Chinese Herbal Medicines Using Modified QuEChERS and High-Performance Liquid Chromatography-Tandem Mass Spectrometry Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-11-12 Nan Fang; Zhou Lu; Zhongbei Zhang; Zhiguang Hou; Shuang Liang; Bo Wang; Zhongbin Lu
In this study, an analytical method for the simultaneous determination of the novel insecticide flupyradifurone and its two metabolites in a variety of traditional Chinese herbal medicines was developed for the first time using high-performance liquid chromatography-tandem mass spectrometry. A simple and efficient method using dispersive solid-phase extraction was employed for the pretreatment of the
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Metabolomics Approach for Discrimination and Quality Control of Natural and Commercial Fallopia multiflora Products in Vietnam Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-11-06 Nguyen Thi Thoa; Nguyen Hai Dang; Do Hoang Giang; Nguyen Thi Thu Minh; Nguyen Tien Dat
A precise HPLC-DAD-based quantification together with the metabolomics statistical method was developed to distinguish and control the quality of Fallopia multiflora, a popular medicinal material in Vietnam. Multivariate statistical methods such as hierarchical clustering analysis and principal component analysis were utilized to compare and discriminate six natural and twelve commercial samples. 2
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Determination of Methomyl Residues in Bohe by Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS) Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-11-05 Yao Zheng; Addotey Tracy Naa Adoley; Benkhelifa Fateh; Wei Wu; Gengdong Hu; Liping Qiu; Jiazhang Chen
The aim of this work is to investigate the presence of methomyl pesticide residue and the rate of disappearance in mint cultivated in the aquaponics system based on the application of UPLC-MS to establish a safety time interval before crop harvesting. Results showed that an effective and sensitive method based on UPLC-MS has been used for the determination of methomyl pesticide residues in mint. The
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Melamine Recognition: Molecularly Imprinted Polymer for Selective and Sensitive Determination of Melamine in Food Samples Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-11-04 Mohadese Biabani; Azizollah Nezhadali; Ahmad Nakhaei; Hossein Nakhaei
In this study, a sensitive and selective sensor is constructed to measure the melamine (MEL) using molecular imprinting polymer (MIP) technique. Chemical and electrochemical techniques are used to construct the MIP and quantitative measurements. The constructed sensor was modified with GO-Fe3O4@SiO2 nanocomposite. Screening and optimization of factors are done using statistical methods, including Plackett–Burman
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Quantitative Determination of Marker Compounds and Fingerprint Analysis of the Seeds of Vernonia anthelmintica Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-10-30 Zulipiya Maimaiti; Ablajan Turak; Qing Ling Ma; Geyu Liu; Haji Akbar Aisa
In traditional Chinese medicine, the seeds of Vernonia anthelmintica (L.) Willd. have been widely used for treatment of cough, skin diseases, diarrhea, fever, schistosomiasis, amoebic dysentery, and gastrointestinal problems, especially in the treatment of vitiligo for thousands of years in China. In this study, an effective, reliable, and accurate high-performance liquid chromatography diode array
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Aptamer-Based Colorimetric Probe for trans-Zeatin Detection Using Unmodified Gold Nanoparticle Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-10-27 Ping Sun; Xiwei Zhang; Xianxiang Wang
Trans-Zeatin is the major active phytohormone in immature corn kernels. Herein, a highly sensitive, good selective and simple aptamer-based colorimetric method for the detection of trans-zeatin was constructed. The selected aptamer sequence binds with trans-zeatin and induces a duplex-to-aptamer structure switching. The gold nanoparticles (AuNPs) solution is stable with high-concentration salt, which
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Study on Reutilization of Pyrolytic Residues of Oily Sludge Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-10-23 Chao Tang; Jiaojiao Guan; Shuixiang Xie
Pyrolytic residues of oily sludge are a kind of hazardous solid waste produced by high-temperature pyrolysis of oily sludge, which still contains a certain amount of mineral oil; improper disposal can cause secondary pollution. In order to reutilize the pyrolytic residues of oily sludge, the pyrolytic carbon in pyrolytic residues is recovered by a combination of physical flotation and chemical separation
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A Simple and Rapid Method for Quantitative HPLC MS/MS Determination of Selected Perfluorocarboxylic Acids and Perfluorosulfonates in Human Serum Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-10-16 Valentina Marra; Annalisa Abballe; Elena Dellatte; Nicola Iacovella; Anna Maria Ingelido; Elena De Felip
Per- and polyfluorinated alkyl substances (PFASs) are ubiquitous environmental contaminants, present in the environment and in the human body. They have raised global concern because of their diffusion in the environment, particularly in water, causing cases of human overexposure due to consumption of contaminated drinking water. Human biomonitoring is the most effective way to characterize human exposure
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Determination of Methomyl Residue in Tobacco Samples by Heart-Cutting Two-Dimensional Liquid Chromatography with Tandem Mass Spectrometry Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-10-13 Shihao Shen; Min Chen; Tiannan Wang; Ting Fei; Dianhai Yang; Miaoling Cao; Da Wu
A novel heart-cutting two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC-MS/MS) was developed for the qualitative and quantitative analysis of methomyl residue in tobacco. Compared to traditional methodologies, fairly high sensitivity and stability were achieved, and the sample procedure was simplified in the two-dimensional liquid chromatography (2D-LC) method. Although
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A Validated Liquid Chromatographic Method for Berberine Analysis in Tissue and Application Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-09-30 Neng Zhou; Dangmei Liu; Xiaowang Bao
Simple and rapid high-performance liquid chromatography methods were developed for the determination of berberine (BB) in various rat tissues so as to evaluate a P-gp inhibitor, glycyrrhetinic acid (GA), on BB’s oral bioavailability. Acetonitrile was used to extract BB from tissues and showed different extraction recoveries in diverse tissues. The intra- and interday precision and accuracy were less
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Investigation on the Effect of Thermal and Mechanical Treatment to the Offshore Corrosion Behavior of 6351 Aluminum Alloy in Red Sea Environments Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-09-26 Yahya Ali Fageehi; Rajasekaran Saminathan
This study investigates the effect of artificial aging treatment and mechanical attrition treatment on the corrosion behavior of 6351 Al alloy in Red Sea environment. The artificial aging of the alloy is carried out at temperature range 140°C–240°C in steps of 20°C for various time periods after the solution heat treatment at 530°C for 1 hour. Based on the hardness measurements, the aged specimens
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A Urine Metabonomics Study of Rat Bladder Cancer by Combining Gas Chromatography-Mass Spectrometry with Random Forest Algorithm Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-09-21 Mengchan Fang; Fan Liu; Lingling Huang; Liqing Wu; Lan Guo; Yiqun Wan
A urine metabolomics study based on gas chromatography-mass spectrometry (GC-MS) and multivariate statistical analysis was applied to distinguish rat bladder cancer. Urine samples with different stages were collected from animal models, i.e., the early stage, medium stage, and advanced stage of the bladder cancer model group and healthy group. After resolving urea with urease, the urine samples were
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Efficient β-Carboline Alkaloid-Based Probe for Highly Sensitive Imaging of Endogenous Glutathione in Wheat Germ Tissues Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-09-15 Xiaohui Ji; Dan Zhang; Le Li; Lingxia Jin; Rui Wu
Discriminative detection of GSH is achieved by employing a highly sensitive and selective fluorescent probe (KL-DN) that bears β-carboline alkaloid as a potential fluorophore and an azide group as the recognition unit. A rapid fluorescence off-on change is caused by special redox reaction; KL-DN has the capability of monitoring endogenous GSH in wheat germ tissues, indicating that this probe holds
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Immunoassay of Glomalin by Quartz Crystal Microbalance Biosensor Containing Iron Oxide Nanoparticles. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-09-01 Miroslav Pohanka,Vitezslav Vlcek
Glomalin is a soil protein resembling heat shock protein (HSP) 60 and exerting high affinity to metals, causing retention of water in the environment and improving mechanical stability of soil. Currently, glomalin is determined in the soil or other samples by combination of autoclaving extraction and total protein determination typically by the Bradford method. In this paper, a piezoelectric biosensor
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Methyl Esterification Combined with Gas Chromatography-Mass Spectrometry (GC-MS) for Determining the Contents of Lubricant to Evaluate the Compatibility of Chlorinated Butyl Rubber Stoppers with Liposome Injections. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-09-01 Xun Gao,Kexin Chen,Miaomiao Chi,Kunming Qin
A simple, sensitive, and exact methyl esterification in combination with gas chromatography-mass spectrometry (GC-MS) method was developed to determine the contents of palmitic acid and stearic acid in the chlorinated butyl rubber stoppers and liposome injections in order to evaluate the compatibility of pharmaceutical packaging materials. In this experiment, palmitic acid and stearic acid were detected
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Physicochemical Quality Characteristics of Southeastern Anatolia Honey, Turkey. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-09-01 Semra Gürbüz,Neslihan Çakıcı,Serdar Mehmetoğlu,Hilal Atmaca,Tahsin Demir,Mukaddes Arıgül Apan,Ömer Faruk Atmaca,Fazıl Güney
This study was performed to investigate the physicochemical quality characteristics of honey produced in Southeastern Anatolia of Turkey. A total of 68 honey samples collected from different beekeepers were analyzed for sugar components, moisture, pH, HMF, electrical conductivity, free acidity, proline values, and diastase number using the methods recommended by the International Honey Commission.
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A GC-MS-Based Metabolomics Investigation of the Protective Effect of Liu-Wei-Di-Huang-Wan in Type 2 Diabetes Mellitus Mice. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-08-13 Jian-Hua Huang,Dan He,Lin Chen,Qing Du,Rong Yu,Ping Cai,Shui-Han Zhang
Aim of the Study. The present study aimed to establish a metabolic profile and to investigate the changes of endogenous metabolites in diabetic mice treated with LWDHW. We further investigated the metabolic mechanism of action for the hypoglycemic activity of LWDHW and its possible role in reducing the risk of renal failure in type 2 diabetic mice. Materials and Methods. MKR mice were used for the
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The Rapid Discrimination and Quality Assessment of Three Zanthoxylum Species Using 1H NMR Spectrometry. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-08-07 Hyeon Seok Jang,Birang Jeong,Seong Yeon Choi,Jiho Lee,Yong Soo Kwon,Heejung Yang
The husks and fruits of Zanthoxylum species (Rutaceae) are the popular pungent and spicy ingredients of foods and the traditional medicines in many countries. Three Zanthoxylum species, Z. bungeanum, Z. schinifolium, and Z. piperitum, are distributed and intermixed with each other as “Zanthoxyli Pericarpium” in Korean markets. In the present study, we analyzed the ethyl acetate-soluble and nonpolar
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Extraction and Characterization of Tunisian Quercus ilex Starch and Its Effect on Fermented Dairy Product Quality. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-08-04 Youkabed Zarroug,Mouna Boulares,Jamel Mejri,Bechir Slimi,Ghaith Hamdaoui,Saida Djebi,Fatma Saidi,Hanen Nasri,Dorra Terras Sfayhi,Mohamed Kharrat
In this study, a new starch has been isolated from acorn (Quercus ilex) fruits. The chemical composition of acorn flour showed its richness in carbohydrates (64.43%), proteins (8%), and fat (10%). The extraction yield of acorn starch was about 34.5%. Thus, the composition of extracted acorn starch and its physical and functional properties were studied. Acorn starch had high purity represented by low
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Chemical Constituents and Anti-Inflammatory Effect of Incense Smoke from Agarwood Determined by GC-MS Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-08-01 De-Qian Peng; Zhang-Xin Yu; Can-Hong Wang; Bao Gong; Yang-Yang Liu; Jian-He Wei
Agarwood is generally used to make incense sticks in China and Southeast Asia. It emits smoke with a pleasant odor when burned. There are few reports on the chemical components of smoke generated by burning or heating agarwood. The agarwoods were produced by the whole-tree agarwood-inducing technique (AWIT), agarwood induced by axe wounds (AAW), burning-chisel-drilling agarwood (BCDA), wood of Aquilaria
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Comparative Analysis of Free Amino Acids and Nucleosides in Different Varieties of Mume Fructus Based on Simultaneous Determination and Multivariate Statistical Analyses. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-08-01 Jinmei Ou,Rui Wang,Xiaoli Li,Luqi Huang,Qingjun Yuan,Chengwu Fang,Deling Wu
Mume Fructus (MF) contains a variety of organic acids, free amino acids, and nucleoside components, and studies have not yet analyzed the relationship between the components of free amino acids and nucleosides with the varieties of MF. A rapid and sensitive method was established for simultaneous determination of 21 free amino acids and 9 nucleosides in MF by ultrafast liquid chromatography-mass spectrometry
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Evaluation of Salt-Induced Damage to Aged Wood of Historical Wooden Buildings. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-08-01 Xiaochen Mi,Tieying Li,Jinping Wang,Yongfeng Hu
Salt is a common cause of damage to building materials used in cultural and historical buildings. The damage to aged wood in historical wooden buildings has not been extensively studied, resulting in the need for a more detailed analysis. In this work, Yingxian Wooden Pagoda, a typical historical wooden structure, was taken as the research object. Multichemical analyses were conducted to evaluate and
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Highly Sensitive Amperometric α-Ketoglutarate Biosensor Based on Reduced Graphene Oxide-Gold Nanocomposites. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-08-01 Gang Peng,Yadong Yu,Xiaojun Chen,He Huang
Herein, a rapid and highly sensitive amperometric biosensor for the detection of α-ketoglutarate (α-KG) was constructed via an electrochemical approach, in which the glutamate dehydrogenase (GLUD) was modified on the surface of reduced graphene oxide-gold nanoparticle composite (rGO-Aunano composite). The rGO-Aunano composite was one-step electrodeposited onto glassy carbon electrode (GCE) surface
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Rapid SERS Detection of Thiol-Containing Natural Products in Culturing Complex. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-08-01 Yan Hong,Rui Wang,Zhuoran Jiang,Zisong Cong,Heng Song
Thiol-containing natural products possess a wide range of bioactivities. The burst of synthetic biology technology facilitates the discovery of new thiol-containing active ingredients. Herein, we report a sensitive, quick, and robust surface-enhanced Raman scattering technology for specific and multiplex detection of thiol-containing compounds without purification requirements and also indicating the
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Derivatization of Levoglucosan for Compound-Specific δ 13C Analysis by Gas Chromatography/Combustion/Isotope Ratio Mass Spectrometry. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-07-26 Dongling Zhang,Swe Swe Aung,Yong Han,Yanlin Zhang,Yingjun Chen,Hongli Li,Feifei Yu,Yangjun Wang,Jialiang Feng,Wu Wang
Levoglucosan is a thermal decomposition product of cellulose in particulate matter. δ13C value of levoglucosan could be used in studying the combustion mechanisms and chemical pathways. In order to introduce a minimum number of carbon atoms, based on the stereostructure of levoglucosan, a two-step derivatization method with methylboronic acid and MSTFA was developed and carefully optimized. The recommended
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A Versatile SERS Sensor for Multiple Determinations of Polycyclic Aromatic Hydrocarbons and Its Application Potential in Analysis of Fried Foods. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-07-23 Shi Wang,Jie Cheng,Caiqin Han,Jianchun Xie
Polycyclic aromatic hydrocarbons (PAHs), due to their high hydrophobicity, have low affinity for metallic SERS-active surfaces, which leads to their low SERS detection sensitivity. Various functional groups have been used to improve the affinity of metallic substrates towards the target PAHs. However, a large portion of the signals generated from the “first-layer effect” of the functionalized substrates
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Simultaneous Quantification of γ-Hydroxybutyrate, γ-Butyrolactone, and 1,4-Butanediol in Four Kinds of Beverages. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-07-15 Shaoming Jin,Xiao Ning,Jin Cao,Yaonan Wang
γ-Hydroxybutyrate (GHB) is a neurotransmitter, which exhibits a strong central nervous system depressant effect. The abuse of GHB or its precursor substances (γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD)) may cause serious problems. This study developed a fast and effective UHPLC-MS/MS method for the simultaneous quantification of GHB, GBL, and 1,4-BD in four popular beverages, including carbonated
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Prevalidation of an ELISA for Detection of a New Clinical Entity: Leishmania donovani-Induced Cutaneous Leishmaniasis. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-07-15 Bhagya Deepachandi,Sudath Weerasinghe,Himali Gunathilake,Thisira P Andrahennadi,Mahendra N Wickramanayake,Shantha Siri,Vishvanath Chandrasekharan,Preethi Soysa,Yamuna Siriwardana
Human leishmaniasis which is considered a neglected tropical parasitic disease presents in three main clinical forms (i.e., cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL)) that are mainly determined by its causative species. Leishmania donovani, the most virulent and visceralizing parasite, is increasingly reported to cause CL in many countries in the
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Evaluation of Volatile Compounds during the Fermentation Process of Yogurts by Streptococcus thermophilus Based on Odor Activity Value and Heat Map Analysis. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-07-13 Li Zhang,Si Mi,Ruo-Bing Liu,Ya-Xin Sang,Xiang-Hong Wang
The volatile composition of yogurt produced by Streptococcus thermophilus fermentation at different time points was investigated by gas chromatography-mass spectrometry combined with simultaneous distillation and extraction. A total of 53 volatile compounds including 11 aldehydes, 10 ketones, 8 acids, 7 benzene derivatives, 13 hydrocarbons, and 4 other compounds were identified in all of the samples
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Rapid Detection of Kaempferol Using Surface Molecularly Imprinted Mesoporous Molecular Sieves Embedded with Carbon Dots. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-07-10 Yu He,Junping Wang,Shuo Wang
This work demonstrates rapid sensing of kaempferol using active sensing material synthesized using the one-pot surface-imprinting synthesis method. This sensor consisted of molecularly imprinted polymer (MIP) consisting of mesoporous molecular sieves (SBA-15) loaded with carbon dots (CDs). Fourier transform infrared (FT-IR) spectroscopy confirmed successful incorporation of CDs onto the surface of
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Evaluation of the Effects of Paclobutrazol and Cultivation Years on Saponins in Ophiopogon japonicus Using UPLC-ELSD. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-07-06 Peng Sun,Juhua Tong,Xianen Li
Nowadays, there is a growing concern about the quality of herbs used in traditional Chinese medicine. In this study, we evaluated the impacts of paclobutrazol and cultivation period on steroid saponins in Ophiopogon japonicus. A rapid method to simultaneously determine three principle steroid saponins (ophiopogonins B, D, and D′) using ultraperformance liquid chromatography combined with an evaporative
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RP-HPLC Method Development and Validation of Synthesized Codrug in Combination with Indomethacin, Paracetamol, and Famotidine. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-07-01 Mohyeddin Assali,Murad Abualhasan,Nihal Zohud,Noura Ghazal
Background. Indomethacin is considered a potent nonsteroidal anti-inflammatory drug that could be combined with Paracetamol to have superior and synergist activity to manage pain and inflammation. To reduce the gastric side effect, they could be combined with Famotidine. Methodology. A codrug of Indomethacin and Paracetamol was synthesized and combined in solution with Famotidine. The quantification
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Comprehensive Screening and Identification of Phillyrin Metabolites in Rats Based on UHPLC-Q-Exactive Mass Spectrometry Combined with Multi-Channel Data Mining. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-06-24 Beibei Ma,Jiameng Li,Tianyu Lou,Yaoyue Liang,Chenxiao Wang,Ruiji Li,Tingting Wang,Jinhui Liu,Yudong Guo,Zhibin Wang,Jing Wang
Phillyrin, a well-known bisepoxylignan, has been shown to have many critical pharmacological activities. In this study, a novel strategy for the extensive acquisition and use of data was established based on UHPLC-Q-Exactive mass spectrometry to analyze and identify the in vivo metabolites of phillyrin and to elucidate the in vivo metabolic pathways of phillyrin. Among them, the generation of data
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Relationship between the Molecular Coil Dimension and the Energy Storage Modulus of Polymer Solution Configured with Oilfield-Produced Sewage. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-06-22 Peng Wang,Wenguo Ma,Yunbao Zhang,Qiuyan Yan
Polymer viscoelastic solution is the non-Newtonian fluid and widely used in oil production. In the process of seepage, the mechanism of the polymer solution with different molecular coil dimensions (Dh) flooding on remaining oil is unknown. By using the dynamic light scattering instrument, the molecular coil dimension of the polymer solution is tested. By using the HAAKE rheometer, the creep recovery
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Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-06-17 Farhad Ghanizadeh Gerayeli,Farnaz Hosseini,Zohreh Bagheri,Amir Savardashtaki,Zahra Shabaninejad,Ali Mohammad Amani,Sohrab Najafipour
Zidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987. It is a reverse transcriptase inhibitor. This type of drug stops the reproduction of DNA and decreases the amount of the virus in the patients’ blood. Due to the ability of forming various molecular bonds, silver nanoparticles (AgNPs) are widely used for the detection of large range of agents, including drugs
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Development of the High Sensitivity and Selectivity Method for the Determination of Histamine in Fish and Fish Sauce from Vietnam by UPLC-MS/MS. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-06-17 Quang Hieu Tran,Thanh Tan Nguyen,Kim Phuong Pham
A selective, sensitive, and rapid method by using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the determination of histamine in fish and fish sauce was developed. The optimal conditions of liquid chromatographic separation and mass spectroscopy of histamine have also been investigated. The linear ranges of the method were 20.0 ÷ 1000 ng/mL, and the corresponding
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Pharmacokinetics of Lusutrombopag, a Novel Thrombopoietin Receptor Agonist, in Rats by UPLC-MS/MS. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-05-30 Bo Wang,Feifei Chen,Quan Zhou,Yunfang Zhou,Deru Meng,Peiwu Geng,Ailian Hua,Weiping Ji,Changxiong Wang,Shuanghu Wang,Liming Hu
Lusutrombopag is a second oral thrombopoietin (TPO) receptor agonist that selectively acts on human TPO receptors. In the study, UPLC-MS/MS was used to establish a selective and sensitive method to determine lusutrombopag with poziotinib as IS (internal standard) in rat plasma. Samples were prepared by precipitating protein with acetonitrile as a precipitant. Separation of lusutrombopag and poziotinib
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Analysis of Acrylamide in Dried Blood Spots of Lung Cancer Patients by Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-05-19 Yahdiana Harahap,Camilla Elysia,Zenshiny Starlin,Achmad Mulawarman Jayusman
Acrylamide (AA) is a carcinogenic substance found in food, cigarette smoke and in an environment exposed to acrylamide. This study aims to analyze AA levels in dried blood spot (DBS) samples of lung cancer patients with smoking record, without smoking record, and also in the negative blank. Analysis of AA levels was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS) and DBS extraction
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A Validated RP-HPLC Stability Method for the Estimation of Chlorthalidone and Its Process-Related Impurities in an API and Tablet Formulation. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-04-10 Chaitali Kharat,Vaishali A Shirsat,Yogita M Kodgule,Mandar Kodgule
Low-dose thiazide and thiazide-like diuretics are widely used as first-line therapy for hypertension. Chlorthalidone, a monosulfamyl diuretic, is frequently prescribed in cases of hypertension and congestive heart failure. In this research paper, an improved reverse-phase HPLC method was developed for the simultaneous identification and quantitation of pharmacopoeia-listed and in-house process- and
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Formulation and Physicochemical Evaluation of Lab-Based Aloe adigratana Reynolds Shampoos. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-04-04 Desta Berhe Sbhatu,Goitom Gebreyohannes Berhe,Abadi Gebreyesus Hndeya,Haftom Baraki Abraha,Asmael Abdu,Haftay Abadi Gebru,Molla Gereme Taye,Afework Mulugeta,Micheale Yifter Weldemichael,Hailekiros Tadesse Tekle,Haileselassie Gebremeskel Kidanemariam
Aloe L. species (Aloaceae) are ethnobotanically very valuable plants in many communities and civilizations. Nonetheless, very few species are extensively studied to explore their applications in the pharmaceutical and medical, cosmetic and personal care, food and beverage, and detergent industries. This study evaluated the characteristics and quality of lab-based shampoos formulated from the gel of
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Extraction-Free, Direct Determination of Caffeine in Microliter Volumes of Beverages by Thermal Desorption-Gas Chromatography Mass Spectrometry. Int. J. Anal. Chem. (IF 1.678) Pub Date : 2020-04-01 Xianglu Peng,Melanie Brown,Paul Bowdler,Kevin C Honeychurch
An extraction-free method requiring microliter (μL) volumes has been developed for the determination of caffeine in beverages. Using a pyrolysis-gas chromatography mass spectrometry system, the conditions required for the direct thermal desorption-gas chromatography mass spectrometry (TD-GC/MS) determination of caffeine were optimised. A 5 μL aliquot was introduced to the thermal desorption unit, dried