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Radiotracer labelled thymohydroquinyl gallate capped gold nanoparticles as theranostic radiopharmaceutical for targeted antineoplastic and bioimaging J. Pharm. Anal. (IF 8.8) Pub Date : 2024-03-12 Munaza Batool, Batool Fatima, Dilshad Hussain, Rubaida Mahmood, Muhammad Imran, Saeed Akhter, Muhammad Saqib Khan, Saadat Majeed, Muhammad Najam-ul-Haq
Thymoquinone (Tq) and gallic acid (GA) are known for counter-tumorigenic characteristics. GA inhibits cancer cell proliferation by interfering with many apoptotic signaling pathways, producing more reactive oxygen species (ROS), focusing on the cell cycle, and suppressing the expression of oncogenes and matrix metalloproteinases (MMPs). In this study, thymoquinone (after reducing to thymohydroquinone)
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Progress and application of intelligent nanomedicine in urinary system tumors J. Pharm. Anal. (IF 8.8) Pub Date : 2024-03-12 Yingming Xiao, Lei Zhong, Jinpeng Liu, Li Chen, Yi Wu, Ge Li
Urinary system tumors include malignancies of the bladder, kidney, and prostate, and present considerable challenges in diagnosis and treatment. The conventional therapeutic approaches against urinary tumors are limited by the lack of targeted drug delivery and significant adverse effects, thereby necessitating novel solutions. Intelligent nanomedicine has emerged as a promising therapeutic alternative
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17β-Estradiol, through activating the G protein-coupled estrogen receptor, exacerbates the complication of benign prostate hyperplasia in type 2 diabetes mellitus patients by inducing prostate proliferation J. Pharm. Anal. (IF 8.8) Pub Date : 2024-03-12 Tingting Yang, Zhen Qiu, Jiaming Shen, Yutian He, Longxiang Yin, Li Chen, Jiayu Yuan, Junjie Liu, Tao Wang, Zhenzhou Jiang, Changjiang Ying, Sitong Qian, Jinfang Song, Xiaoxing Yin, Qian Lu
Benign prostate hyperplasia (BPH) is one of the major chronic complications of type 2 diabetes mellitus (T2DM), and sex steroid hormones are common risk factors for the occurrence of T2DM and BPH. The profiles of sex steroid hormones are simultaneously quantified by LC-MS/MS in the clinical serum of patients, including simple BPH patients, newly diagnosed T2DM patients, T2DM complicated with BPH patients
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Medcheck: a novel software for automatic de-formulation of traditional Chinese medicine (TCM) prescriptions by liquid chromatography-mass spectrometry J. Pharm. Anal. (IF 8.8) Pub Date : 2024-03-12 Xiao-lan Li, Jian-qing Zhang, Yun Li, Xuan-jing Shen, Huan-ya Yang, Lin Yang, Meng Xu, Qi-rui Bi, Chang-liang Yao, De-an Guo
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β-elemene promotes miR-127-3p maturation, induces NSCLCs autophagy, and enhances macrophage M1 polarization through exosomal communication J. Pharm. Anal. (IF 8.8) Pub Date : 2024-03-08 Xiahui Wu, Jie Wu, Tingting Dai, Qiangcheng Wang, Shengjie Cai, Xuehan Wei, Jing Chen, Ziyu Jiang
β-elemene has been observed to exert inhibitory effects on a multitude of tumors, primarily through multiple pathways such as the inhibition of cancer cell proliferation and the induction of apoptosis. The present study is designed to elucidate the role and underlying mechanisms of β-elemene in the therapeutic intervention of non-small cell lung cancer (NSCLC). Both in vitro and in vivo experimental
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Mechanisms and therapeutic targets of ferroptosis: Implications for nanomedicine design J. Pharm. Anal. (IF 8.8) Pub Date : 2024-03-08 Meihong Zhang, Mengqin Guo, Yue Gao, Chuanbin Wu, Xin Pan, Zhengwei Huang
Ferroptosis is a nonapoptotic form of cell death and differs considerably from the well-known forms of cell death in terms of cell morphology, genetics, and biochemistry. The three primary pathways for cell ferroptosis are system Xc/glutathione peroxidase 4, lipid metabolism, and ferric metabolism. Since the discovery of ferroptosis, mounting evidence has revealed its critical regulatory role in several
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Recent Trends and Impact of Localized Surface Plasmon Resonance (LSPR) and Surface-Enhanced Raman Spectroscopy (SERS) in Modern Analysis J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-28 Bibhu Prasad Nanda, Priyanka Rani, Priyanka Paul, Ganti Subrahmanya S, Rohit Bhatia
An optical biosensor is a specialized analytical device that utilizes the principles of optics and light bimolecular processes. Localized surface plasmon resonance (LSPR) is a phenomenon in the realm of nanophotonics that arises when metallic nanoparticles (NPs) or nanostructures interact with incident light. On the other hand, surface-enhanced Raman spectroscopy (SERS) is an influential analytical
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Oxalate regulates crystal-cell adhesion and macrophage metabolism via JPT2/PI3K/AKT signaling to promote the progression of kidney stones J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-27 Qianlin Song, Chao Song, Xin Chen, Yunhe Xiong, Ziqi He, Xiaozhe Su, Jiawei Zhou, Hu Ke, Caitao Dong, Wenbiao Liao, Sixing Yang
Oxalate is an organic dicarboxylic acid that is a common component of plant foods. The kidneys are essential organs for oxalate excretion, but excessive oxalates may induce kidney stones. Jupiter microtubule associated homolog 2 (JPT2) is a critical molecule in Ca mobilization, and its intrinsic mechanism in oxalate exposure and kidney stones remains unclear. This study aimed to reveal the mechanism
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An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-27 Xinyang Zhu, Chao He, Longfei Tan, Xun Qi, Meng Niu, Xianwei Meng, Hongshan Zhong
Microwave thermotherapy (MWTT), as a treatment for tumors, lacks specificity and requires sensitizers. Most reported microwave sensitizers are single-metal organic frameworks (MOFs), which must be loaded with ionic liquids to enhance the performance in MWTT. Meanwhile, MWTT is rarely combined with other treatment modalities. Here, we synthesized a novel Fe-Cu bimetallic organic framework FeCuMOF (FCM)
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Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-24 Meiyu Qu, Qiangqiang He, Hangyang Bao, Xing Ji, Tingyu Shen, Muhammad Qasim Barkat, Ximei Wu, Ling-Hui Zeng
Arsenic compounds are widely used for the therapeutic intervention of multiple diseases. Ancient pharmacologists discovered the medicinal utility of such highly toxic substances, and modern pharmacologists have further recognized the specific active ingredients in human diseases. In particular, Arsenic trioxide (ATO), as a main component, has therapeutic effects on various tumors (including leukemia
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Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-23 Fulin Jiang, Jingyu Liu, Yagang Li, Zihan Lu, Qian Liu, Yunhui Xing, Janshon Zhu, Min Huang, Guoping Zhong
Liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS) is a widely utilized technique for in vivo pharmaceutical analysis. Ionization interference within electrospray ion source, occurring between drugs and metabolites, can lead to signal variations, potentially compromising quantitative accuracy. Currently, method validation often overlooks this type of signal interference
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β-glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-23 Wen Guo, Xinyue Zhang, Long Wan, Zhiqi Wang, Meiqi Han, Ziwei Yan, Jia Li, Ruizhu Deng, Shenglong Li, Yuling Mao, Siling Wang
Particle size and surface properties are crucial for lymphatic drainage (LN), dendritic cell (DC) uptake, DC maturation, and antigen cross-presentation induced by nanovaccine injection, which lead to an effective cell-mediated immune response. However, the manner in which the particle size and surface properties of vaccine carriers such as mesoporous silica nanoparticles (MSNs) affect this immune response
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IR-EcoSpectra: Exploring sustainable ex situ and in situ FTIR applications for green chemical and pharmaceutical analysis J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-22 Alina Cherniienko, Roman Lesyk, Lucjusz Zaprutko, Anna Pawełczyk
In various industries, particularly the chemical and pharmaceutical fields, Fourier transform infrared spectroscopy (FTIR) spectroscopy provides a unique capacity to detect and characterise complex chemicals while minimising environmental damage by minimal waste generation and reducing the need for extensive sample preparation or use of harmful reagents. This review showcases the versatility of and
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MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-10 Haowei Zhang, Qixin Li, Xiaolong Guo, Hong Wu, Chenhao Hu, Gaixia Liu, Tianyu Yu, Xiake Hu, Quanpeng Qiu, Gang Guo, Junjun She, Yinnan Chen
Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer (CRC). Cisplatin-resistant cells exhibit an inherent ability to evade the toxic chemotherapeutic drug effects which are characterized by the activation of slow-cycle programs and DNA repair. Among the elements that lead to cisplatin resistance, -methylguanine (-MG)-DNA-methyltransferase
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Automated and integrated ultrahigh throughput industrial strain screening enabled by acoustic-droplet-ejection mass spectrometry J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-10 Zhidan Zhang, Chao Zhang, Xu Zhang, Jiuzhou Chen, Ningyun Cai, Shasha Zhong, Zhibo Han, Yan Zhu, Ping Zheng, Jibin Sun, Changxiao Liu
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Non-coding RNAs as therapeutic targets in cancer and its clinical application J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-08 Xuejiao Leng, Mengyuan Zhang, Yujing Xu, Jingjing Wang, Ning Ding, Yancheng Yu, Shanliang Sun, Weichen Dai, Xin Xue, Nianguang Li, Ye Yang, Zhihao Shi
Cancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression. Oncogenes promote cell growth and proliferation, whereas tumor suppressor genes inhibit cell growth and division. The dysregulation of these genes can lead to the development of cancer. Recent studies have focused on non-coding RNAs (ncRNAs), including
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Bio-soft matter derived from traditional Chinese medicine: characterizations of hierarchical structure, assembly mechanism, and beyond J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-07 Guiya Yang, Yue Liu, Yuying Hu, Yue Yuan, Yunan Qin, Quan Li, Shuangcheng Ma
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Natural compounds improve diabetic nephropathy by regulating the TLR4 signaling pathway J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-06 Jiabin Wu, Ke Li, Muge Zhou, Haoyang Gao, Wenhong Wang, Weihua Xiao
Diabetic nephropathy (DN), a severe complication of diabetes, is widely recognized as a primary contributor to end-stage renal disease. Recent studies indicate that the inflammation triggered by Toll-like receptor 4 (TLR4) is of paramount importance in the onset and progression of DN. TLR4 can bind to various ligands, including exogenous ligands such as proteins and polysaccharides from bacteria or
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Global hotspots and future directions for drugs to improve the skin flap survival: A bibliometric and visualized review J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-06 Shuangmeng Jia, Jieshen Huang, Wuyan Lu, Yongen Miao, Kehua Huang, Chenchang Shi, Shuaijun Li, Jiefeng Huang
Skin flaps are frequently employed in plastic and reconstructive surgery to address tissue defects. However, their low survival rates remain a challenge, attributed to vascular crisis and necrosis. Despite numerous studies investigating drugs to alleviate flap necrosis, a comprehensive analysis of the research trend in this critical area is lacking. To gain a deeper understanding of the current status
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A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by Autodisplay-based screening J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-05 Alexander DOMBOVSKI, Ruben STEIGERWALD, Nadine RITTER, Paul DISSE, Gunnar GOERGES, Jana OSTHUES, Isabel AYMANNS, Carina DILKAUTE, Julian SCHREIBER, Martina DÜFER, Guiscard SEEBOHM, Bernhard WÜNSCH, Joachim JOSE
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Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-03 Shu Yang, Zhonghua Wang, Yanhua Liu, Xin Zhang, Hang Zhang, Zhaoying Wang, Zhi Zhou, Zeper Abliz
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Melatonin enhances the efficacy of anti-PD-L1 by improving hypoxia in residual tumors after insufficient radiofrequency ablation J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-02 Yanqiao Ren, Licheng Zhu, Yusheng Guo, Jinqiang Ma, Lian Yang, Chuansheng Zheng, Xiangjun Dong
The hypoxic microenvironment and inflammatory state of residual tumors caused by insufficient radiofrequency ablation (iRFA) are major reasons for rapid tumor progression and pose challenges for immunotherapy. We retrospectively analyzed the clinical data of patients with hepatocellular carcinoma (HCC) treated with RFA and observed that iRFA was associated with poor survival outcomes and progression-free
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In situ repolarization of Tumor-Associated Macrophages with synergic nanoformulation to reverse immunosuppressive TME in mouse breast cancer for cancer therapy J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-02 Ruhua Luo, Zhongyu Yue, Qian Yang, Honghua Zhang, Tian Xie, Shuling Wang, Qingchang Tian
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Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells J. Pharm. Anal. (IF 8.8) Pub Date : 2024-02-02 Shaowei Huang, Xueqian Xie, Bo Xu, Zengfeng Pan, Junjie Liang, Meiling Zhang, Simin Pan, Xiaojing Wang, Meng Zhao, Qing Wang, Jinyan Chen, Yanyang Li, Lian Zhou, Xia Luo
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PEG-PLGA nanoparticles deposited in Pseudomonas aeruginosa and Burkolderia cenocepacia J. Pharm. Anal. (IF 8.8) Pub Date : 2024-01-26 Tinatini Tchatchiashvilli, Helena Duering, Lisa Mueller-Boetticher, Christian Grune, Dagmar Fischer, Mathias W. Pletz, Oliwia Makarewicz
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Discovery of potent anti-MRSA components from Dalbergia odorifera through UPLC-Q-TOF-MS and targeting PBP2a protein through in-depth transcriptomic, in vitro, and in-silico studies J. Pharm. Anal. (IF 8.8) Pub Date : 2024-01-23 Jiajia Wu, Syed Shams ul Hassan, Xue Zhang, Tao Li, Abdur Rehman, Shikai Yan, Huizi Jin
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Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy J. Pharm. Anal. (IF 8.8) Pub Date : 2024-01-17 Xiaopeng Li, Yang Zhong, Pengyuan Qi, Daoming Zhu, Chenglong Sun, Nan Wei, Yang Zhang, Zhanggui Wang
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Targeted delivery of rosuvastatin enhances treatment of HHcy-induced atherosclerosis using macrophage membrane-coated nanoparticles J. Pharm. Anal. (IF 8.8) Pub Date : 2024-01-13 Dayue Liu, Anning Yang, Yulin Li, Zhenxian Li, Peidong You, Hongwen Zhang, Shangkun Quan, Yue Sun, Yaling Zeng, Shengchao Ma, Jiantuan Xiong, Yinju Hao, Guizhong Li, Bin Liu, Huiping Zhang, Yideng Jiang
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Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin J. Pharm. Anal. (IF 8.8) Pub Date : 2024-01-14 Xinyue Yang, Yingyu Sima, Xuhuai Luo, Yaping Li, Min He
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Renal tubular epithelial cell quality control mechanisms as therapeutic targets in renal fibrosis J. Pharm. Anal. (IF 8.8) Pub Date : 2024-01-03 Yini Bao, Qiyuan Shan, Keda Lu, Qiao Yang, Ying Liang, Haodan Kuang, Lu Wang, Min Hao, Mengyun Peng, Shuosheng Zhang, Gang Cao
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In situ visualization of the cellular uptake and sub-cellular distribution of mussel oligosaccharides J. Pharm. Anal. (IF 8.8) Pub Date : 2024-01-04 Zhenjie Yu, Huarong Shao, Xintian Shao, Linyan Yu, Yanan Gao, Youxiao Ren, Fei Liu, Caicai Meng, Peixue Ling, Qixin Chen
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Baicalin alleviates chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor J. Pharm. Anal. (IF 8.8) Pub Date : 2024-01-04 Qi Jia, Yinyin Zhou, Li Song, Ximeng Shi, Xuan Jiang, Ruizhi Tao, Aiyun Wang, Yuanyuan Wu, Zhonghong Wei, Yinan Zhang, Xiaoman Li, Yin Lu
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New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation J. Pharm. Anal. (IF 8.8) Pub Date : 2024-01-03 Li Zhang, Li Yue Xu, Fei Tang, Dong Liu, Xiao Lan Zhao, Jing Nan Zhang, Jia Xia, Jiao Jiao Wu, Yu Yang, Cheng Peng, Hui Ao
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Dynamic gut microbiome-metabolome in c-BSA induced experimental immune-complex glomerulonephritis and effect of losartan and MMF on microbiota modulation J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-30 Wenying Shi, Zhaojun Li, Weida Wang, Xikun Liu, Haijie Wu, Xiaoguang Chen, Xunrong Zhou, Sen Zhang
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Discrimination of Polysorbate 20 by High-Performance Liquid Chromatography-Charged Aerosol Detection and Characterization for Components by Expanding Compound Database and Library J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-30 Shi-Qi Wang, Xun Zhao, Li-Jun Zhang, Yue-Mei Zhao, Lei Chen, Jin-Lin Zhang, Bao-Cheng Wang, Sheng Tang, Tom Yuan, Yaozuo Yuan, Mei Zhang, Hian Kee Lee, Hai-Wei Shi
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Design of a Nanozyme−Based Magnetic Nanoplatform to Enhance Photodynamic Therapy and Immunotherapy J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-28 Chen Bai, Jiajing Liu, Luyao Bai, Dapeng Yao, Xiaofeng Li, Haoran Zhang, Dong Guo
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Corrigendum to “GB7 acetate, a galbulimima alkaloid from Galbulimima belgraveana, possesses anticancer effects in colorectal cancer cells” [J. Pharm. Anal. 12 (2022) 339–349] J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-27 Ziyin Li, Lianzhi Mao, Bin Yu, Huahuan Liu, Qiuyu Zhang, Zhongbo Bian, Xudong Zhang, Wenzhen Liao, Suxia Sun
Abstract not available
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Lentinan-functionalized PBAE-G-nanodiamonds as an adjuvant to induce cGAS-STING pathway-mediated macrophage activation and immune enhancement J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-22 Zhiqiang Zhang, Li Wang, Xia Ma, Hui Wang
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Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-22 Guiqin Ye, Xin Sun, Jiuzhou Li, Yuanyuan Mai, Ruilan Gao, Jianbin Zhang
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Rapid discovery of a novel “green” and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-21 Linxi Mao, Yan Qin, Jialong Fan, Wei Yang, Bin Li, Liang Cao, Liqin Yuan, Mengyun Wang, Bin Liu, Wei Wang
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Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-21 Xin Han, Yan Ning, Xinyue Dou, Yiwen Wang, Qiyuan Shan, Kao Shi, Zeping Wang, Chuan Ding, Min Hao, Kuilong Wang, Mengyun Peng, Haodan Kuang, Qiao Yang, Xianan Sang, Gang Cao
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3D-Printed Constructs Deliver Bioactive Cargos to Expedite Cartilage Regeneration J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-21 Rong Jiao, Xia Lin, Jingchao Wang, Chunyan Zhu, Jiang Hu, Huali Gao, Kun Zhang
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Extracellular Vesicles in Anti-tumor Drug Resistance: Mechanisms and Therapeutic Prospects J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-16 Hao-Yang Cheng, Guang-Liang Su, Yu-Xuan Wu, Gang Chen, Zi-Li Yu
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Measurement of very low-molecular weight metabolites by traveling wave ion mobility and its use in human urine samples J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-16 Alongkorn Kurilung, Suphitcha Limjiasahapong, Khwanta Kaewnarin, Pattipong Wisanpitayakorn, Narumol Jariyasopit, Kwanjeera Wanichthanarak, Sitanan Sartyoungkul, Stephen Choong Chee Wong, Nuankanya Sathirapongsasuti, Chagriya Kitiyakara, Yongyut Sirivatanauksorn, Sakda Khoomrung
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New Advances of adiponectin in regulating obesity and related metabolic syndromes J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-13 Yanqi Han, Qianwen Sun, Wei Chen, Yue Gao, Jun Ye, Yanmin Chen, Tingting Wang, Lili Gao, Yuling Liu, Yanfang Yang
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Nitrosamines crisis in pharmaceuticals - insights on toxicological implications, root causes and risk assessment: A systematic review J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-12 Hemanth P.R. Vikram, Tegginamath Pramod Kumar, Gunjan Kumar, Narasimha M. Beeraka, Rajashree Deka, Sheik Mohammed Suhail, Sandeep Jat, Namitha Bannimath, Gayatiri Padmanabhan, Ravandur S. Chandan, Pramod Kumar, Bannimath Gurupadayya
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Perspective on in vivo SPME for human applications: starting from monitoring doxorubicin during lung chemo-perfusion J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-12 Wei Zhou, Runshan Will Jiang, Barbara Bojko, Janusz Pawliszyn
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MEOX2 promotes glioma growth and temozolomide chemoresistance J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-10 Tengfei Li, Kaijun Sun, Wanchun Yang, Meiling Zhang, Wentao Feng, Siliang Chen, Mingrong Zuo, Qiuyun Yuan, Yanhui Liu, Mina Chen
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Traditional Chinese Medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signaling J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-10 Bei Li, Yong Zhang, Xinyuan Liu, Ziyang Zhang, Shuqing Zhuang, Xiaoli Zhong, WenBo Chen, Yilin Hong, Pingli Mo, Shuhai Lin, Shicong Wang, Chundong Yu
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Basic Regulatory Science Behind Drug Substance and Drug Product Specifications of Monoclonal Antibodies and Other Protein Therapeutics J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-10 Patanachai K. Limpikirati, Sorrayut Mongkoltipparat, Thinnaphat Denchaipradit, Nathathai Siwasophonpong, Wudthipong Pornnopparat, Parawan Ramanandana, Phumrapee Pianpakt, Songsak Tongchusak, Maoxin Tim Tian, Trairak Pisitkun
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Model informed Precision Medicine of Chinese Herbal Medicines Formulas- A Multi-scale Mechanistic Intelligent Model J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-09 Yuanyuan Qian, Xiting Wang, Lulu Cai, Jiangxue Han, Zhu Huang, Yahui Lou, Bingyue Zhang, Yanjie Wang, Xiaoning Sun, Yan Zhang, Aisong Zhu
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GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-09 Jiani Zhong, Hang Chen, Qiming Liu, Shenghua Zhou, Zhenguo Liu, Yichao Xiao
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Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice J. Pharm. Anal. (IF 8.8) Pub Date : 2023-12-08 Ting Gao, Yixuan Li, Xiaoyu Wang, Fazheng Ren
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An Enviromentally Sensitive Zinc-Selective Two-Photon NIR Fluorescent Turn-on probe And Zinc sensing In Stroke J. Pharm. Anal. (IF 8.8) Pub Date : 2023-11-29 Junfeng Wang, Qibing Liu, Yingbo Li, Yi Pang
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Integrated Spatial Metabolomics and Transcriptomics Decipher the Hepatoprotection Mechanisms of Wedelolactone and Demethylwedelolactone on Non-alcoholic Fatty Liver Disease J. Pharm. Anal. (IF 8.8) Pub Date : 2023-11-29 Panpan Chen, Zihan Zhu, Haoyuan Geng, Xiaoqing Cui, Yuhao Han, Lei Wang, Yaqi Zhang, Heng Lu, Xiao Wang, Yun Zhang, Chenglong Sun
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YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling J. Pharm. Anal. (IF 8.8) Pub Date : 2023-11-29 Hua Sui, Wanli Deng, Qiong Chai, Bing Han, Yuli Zhang, Zhenzhen Wei, Zan Li, Ting Wang, Jiling Feng, Man Yuan, Qingfeng Tang, Hongxi Xu
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Contemporary strategies and approaches for characterizing composition and enhancing biofilm penetration targeting bacterial extracellular polymeric substances J. Pharm. Anal. (IF 8.8) Pub Date : 2023-11-29 Lan Lu, Yuting Zhao, Mingxing Li, Xiaobo Wang, Jie Zhu, Li Liao, Jingya Wang