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  • Evolution of Analytical Sciences in the United States: A Historical Account
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Gary D. Christian

    The current teaching and practice of analytical chemistry reflect the evolution of measurement science over time. Qualitative and quantitative measurements can be traced back to prebiblical times, have been important throughout human history, and today are key to the functioning of a modern society. This review is designed to provide a brief overview of the evolution of analytical science and a summary

    更新日期:2020-06-12
  • NIST Reference Materials: Utility and Future.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Steven J Choquette,David L Duewer,Katherine E Sharpless

    The National Institute of Standards and Technology (NIST), formerly the National Bureau of Standards, was established by the US Congress in 1901 and charged with establishing a measurement foundation to facilitate US and international commerce. This broad language provides NIST with the ability to establish and implement its programs in response to changes in national needs and priorities. This review

    更新日期:2020-06-12
  • Emerging Standards and Analytical Science for Nanoenabled Medical Products
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Bryant C. Nelson; Caterina Minelli; Shareen H. Doak; Matthias Roesslein

    Development and application of nanotechnology-enabled medical products, including drugs, devices, and in vitro diagnostics, are rapidly expanding in the global marketplace. In this review, the focus is on providing the reader with an introduction to the landscape of commercially available nanotechnology-enabled medical products as well as an overview of the international documentary standards and reference

    更新日期:2020-06-12
  • Petroleomics: Tools, Challenges, and Developments.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Diana Catalina Palacio Lozano,Mary J Thomas,Hugh E Jones,Mark P Barrow

    The detailed molecular characterization of petroleum-related samples by mass spectrometry, often referred to as petroleomics, continues to present significant analytical challenges. As a result, petroleomics continues to be a driving force for the development of new ultrahigh resolution instrumentation, experimental methods, and data analysis procedures. Recent advances in ionization, resolving power

    更新日期:2020-06-12
  • Three-Dimensional Single Particle Tracking and Its Applications in Confined Environments
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Yaning Zhong; Gufeng Wang

    Single particle tracking (SPT) has proven to be a powerful technique in studying molecular dynamics in complicated systems. We review its recent development, including three-dimensional (3D) SPT and its applications in probing nanostructures and molecule-surface interactions that are important to analytical chemical processes. Several frequently used 3D SPT techniques are introduced. Especially of

    更新日期:2020-06-12
  • Making Sharper Peaks for Reverse-Phase Liquid Chromatography of Proteins
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Charles R. Bupp; Mary J. Wirth

    Protein separations have gained increasing interest over the past two decades owing to the dramatic growth of proteins as therapeutics and the completion of the Human Genome Project. About every decade, the field of protein high-performance liquid chromatography (HPLC) seems to mature, having reached what appears to be a theoretical limit. But then scientists well versed in the basic principles of

    更新日期:2020-06-12
  • Single-Molecule Imaging of Protein Interactions and Dynamics.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Fang Luo,Gege Qin,Tie Xia,Xiaohong Fang

    Live-cell single-molecule fluorescence imaging has become a powerful analytical tool to investigate cellular processes that are not accessible to conventional biochemical approaches. This has greatly enriched our understanding of the behaviors of single biomolecules in their native environments and their roles in cellular events. Here, we review recent advances in fluorescence-based single-molecule

    更新日期:2020-06-12
  • Proteomics of Select Neglected Tropical Diseases
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Anthony J. Saviola; Fernanda Negrão; John R. Yates III

    Technological advances in mass spectrometry have enabled the extensive identification, characterization, and quantification of proteins in any biological system. In disease processes proteins are often altered in response to external stimuli; therefore, proteomics, the large-scale study of proteins and their functions, represents an invaluable tool for understanding the molecular basis of disease.

    更新日期:2020-06-12
  • Lighting Up Live-Cell and In Vivo Central Carbon Metabolism with Genetically Encoded Fluorescent Sensors
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Zhuo Zhang; Xiawei Cheng; Yuzheng Zhao; Yi Yang

    As the core component of cell metabolism, central carbon metabolism, consisting of glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle converts nutrients into metabolic precursors for biomass and energy to sustain the life of virtually all extant species. The metabolite levels or distributions in central carbon metabolism often change dynamically with cell fates, development

    更新日期:2020-06-12
  • NanoSIMS Imaging and Analysis in Materials Science
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Kexue Li; Junliang Liu; Chris R.M. Grovenor; Katie L. Moore

    High-resolution SIMS analysis can be used to explore a wide range of problems in material science and engineering materials, especially when chemical imaging with good spatial resolution (50–100 nm) can be combined with efficient detection of light elements and precise separation of isotopes and isobaric species. Here, applications of the NanoSIMS instrument in the analysis of inorganic materials are

    更新日期:2020-06-12
  • Lipid Diversity in Cells and Tissue Using Imaging SIMS.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Sanna Sämfors,John S Fletcher

    Lipids are an important class of biomolecules with many roles within cells and tissue. As targets for study, they present several challenges. They are difficult to label, as many labels lack the specificity to the many different lipid species or the labels maybe larger than the lipids themselves, thus severely perturbing the natural chemical environment. Mass spectrometry provides exceptional specificity

    更新日期:2020-06-12
  • Mass Spectrometry of Human Transporters
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Brahim Achour; Zubida M. Al-Majdoub; Amin Rostami-Hodjegan; Jill Barber

    Transporters are key to understanding how an individual will respond to a particular dose of a drug. Two patients with similar systemic concentrations may have quite different local concentrations of a drug at the required site. The transporter profile of any individual depends upon a variety of genetic and environmental factors, including genotype, age, and diet status. Robust models (virtual patients)

    更新日期:2020-06-12
  • Single Crystal Electrochemistry as an In Situ Analytical Characterization Tool.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Víctor Climent,Juan Feliu

    The electrochemical behavior of platinum single crystal surfaces can be taken as a model response for the interpretation of the activity of heterogeneous electrodes. The cyclic voltammogram of a given platinum electrode can be considered a fingerprint characteristic of the distribution of sites on its surface. We start this review by providing some simple mathematical descriptions of the voltammetric

    更新日期:2020-06-12
  • Functional Molecular Interfaces for Impedance-Based Diagnostics.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Prosper Kanyong,Amol V Patil,Jason J Davis

    In seeking to develop and optimize reagentless electroanalytical assays, a consideration of the transducing interface features lies key to any subsequent sensitivity and selectivity. This review briefly summarizes some of the most commonly used receptive interfaces that have been employed within the development of impedimetric molecular sensors. We discuss the use of high surface area carbon, nanoparticles

    更新日期:2020-06-12
  • Electrochemistry of Single-Vesicle Events.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Jacqueline D Keighron,Yuanmo Wang,Ann-Sofie Cans

    Neuronal transmission relies on electrical signals and the transfer of chemical signals from one neuron to another. Chemical messages are transmitted from presynaptic neurons to neighboring neurons through the triggered fusion of neurotransmitter-filled vesicles with the cell plasma membrane. This process, known as exocytosis, involves the rapid release of neurotransmitter solutions that are detected

    更新日期:2020-06-12
  • Functionalized Silicon Electrodes in Electrochemistry.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Vinicius R Gonçales,Jiaxin Lian,Shreedhar Gautam,Richard D Tilley,J Justin Gooding

    Avoiding the growth of SiOx has been an enduring task for the use of silicon as an electrode material in dynamic electrochemistry. This is because electrochemical assays become unstable when the SiOx levels change during measurements. Moreover, the silicon electrode can be completely passivated for electron transfer if a thick layer of insulating SiOx grows on the surface. As such, the field of silicon

    更新日期:2020-06-12
  • Clinically Relevant Tissue Scale Responses as New Readouts from Organs-on-a-Chip for Precision Medicine
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Olivier T. Guenat; Thomas Geiser; François Berthiaume

    Organs-on-chips (OOC) are widely seen as being the next generation in vitro models able to accurately recreate the biochemical-physical cues of the cellular microenvironment found in vivo. In addition, they make it possible to examine tissue-scale functional properties of multicellular systems dynamically and in a highly controlled manner. Here we summarize some of the most remarkable examples of OOC

    更新日期:2020-06-12
  • Advances in Paper-Based Analytical Devices
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Tugba Ozer; Catherine McMahon; Charles S. Henry

    Microfluidic paper-based analytical devices (μPADs) are the newest generation of lab-on-a-chip devices and have made significant strides in both our understanding of fundamental behavior and performance characteristics and expansion of their applications. μPADs have become useful analytical techniques for environmental analysis in addition to their more common application as medical point-of-care devices

    更新日期:2020-06-12
  • Microfluidic Immunoassays for Time-Resolved Measurement of Protein Secretion from Single Cells
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Mai Yamagishi; Osamu Ohara; Yoshitaka Shirasaki

    Measurement of humoral factors secreted from cells has served as an indispensable method to monitor the states of a cell ensemble because humoral factors play crucial roles in cell–cell interaction and aptly reflect the states of individual cells. Although a cell ensemble consisting of a large number of cells has conventionally been the object of such measurements, recent advances in microfluidic technology

    更新日期:2020-06-12
  • Acoustic Microfluidics.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Peiran Zhang,Hunter Bachman,Adem Ozcelik,Tony Jun Huang

    Acoustic microfluidic devices are powerful tools that use sound waves to manipulate micro- or nanoscale objects or fluids in analytical chemistry and biomedicine. Their simple device designs, biocompatible and contactless operation, and label-free nature are all characteristics that make acoustic microfluidic devices ideal platforms for fundamental research, diagnostics, and therapeutics. Herein, we

    更新日期:2020-06-12
  • 3D Printed Microfluidics.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Anna V Nielsen,Michael J Beauchamp,Gregory P Nordin,Adam T Woolley

    Traditional microfabrication techniques suffer from several disadvantages, including the inability to create truly three-dimensional (3D) architectures, expensive and time-consuming processes when changing device designs, and difficulty in transitioning from prototyping fabrication to bulk manufacturing. 3D printing is an emerging technique that could overcome these disadvantages. While most 3D printed

    更新日期:2020-06-12
  • Autobiography of an Analytical Chemist.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2020-06-12
    Edward S Yeung

    Most of my research directions were opportunistic. Having worked with lasers in the early stages of laser applications in analytical chemistry, attending conferences, workshops, and administrative meetings that were not exactly aligned with our own research, locating to a building or in a department that housed scientists with different backgrounds, having certain specialized equipment at the right

    更新日期:2020-06-12
  • Imaging and Analytics on the Helium Ion Microscope.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Tom Wirtz,Olivier De Castro,Jean-Nicolas Audinot,Patrick Philipp

    The helium ion microscope (HIM) has emerged as an instrument of choice for patterning, imaging and, more recently, analytics at the nanoscale. Here, we review secondary electron imaging on the HIM and the various methodologies and hardware components that have been developed to confer analytical capabilities to the HIM. Secondary electron-based imaging can be performed at resolutions down to 0.5 nm

    更新日期:2020-04-21
  • Solving the Structure and Dynamics of Metal Nanoparticles by Combining X-Ray Absorption Fine Structure Spectroscopy and Atomistic Structure Simulations.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    J Timoshenko,Z Duan,G Henkelman,R M Crooks,A I Frenkel

    Extended X-ray absorption fine structure (EXAFS) spectroscopy is a premiere method for analysis of the structure and structural transformation of nanoparticles. Extraction of analytical information about the three-dimensional structure and dynamics of metal-metal bonds from EXAFS spectra requires special care due to their markedly non-bulk-like character. In recent decades, significant progress has

    更新日期:2020-04-21
  • Separation Phenomena in Tailored Micro- and Nanofluidic Environments.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Mukul Sonker,Daihyun Kim,Ana Egatz-Gomez,Alexandra Ros

    Separations of bioanalytes require robust, effective, and selective migration phenomena. However, due to the complexity of biological matrices such as body fluids or tissue, these requirements are difficult to achieve. The separations field is thus constantly evolving to develop suitable methods to separate biomarkers and fractionate biospecimens for further interrogation of biomolecular content. Advances

    更新日期:2020-04-21
  • Well-Defined Materials for High-Performance Chromatographic Separation.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Yu Liang,Lihua Zhang,Yukui Zhang

    Chromatographic separation has been widely applied in various fields, such as chemical engineering, precision medicine, energy, and biology. Because chromatographic separation is based on differential partitioning between the mobile phase and stationary phase and affected by band dispersion and mass transfer resistance from these two phases, the materials used as the stationary phase play a decisive

    更新日期:2020-04-21
  • Single-Cell Protein Secretion Detection and Profiling.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Zhuo Chen,Jonathan J Chen,Rong Fan

    Secreted proteins play important roles in mediating various biological processes such as cell-cell communication, differentiation, migration, and homeostasis at the population or tissue level. Here, we review bioanalytical technologies and devices for detecting protein secretions from single cells. We begin by discussing conventional approaches followed by detailing the latest advances in microengineered

    更新日期:2020-04-21
  • High-Parameter Single-Cell Analysis.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Pratip K Chattopadhyay,Aidan F Winters,Woodrow E Lomas,Andressa S Laino,David M Woods

    Thousands of transcripts and proteins confer function and discriminate cell types in the body. Using high-parameter technologies, we can now measure many of these markers at once, and multiple platforms are now capable of analysis on a cell-by-cell basis. Three high-parameter single-cell technologies have particular potential for discovering new biomarkers, revealing disease mechanisms, and increasing

    更新日期:2020-04-21
  • Flow Cytometric Analysis of Nanoscale Biological Particles and Organelles.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Hong Lian,Shengbin He,Chaoxiang Chen,Xiaomei Yan

    Analysis of nanoscale biological particles and organelles (BPOs) at the single-particle level is fundamental to the in-depth study of biosciences. Flow cytometry is a versatile technique that has been well-established for the analysis of eukaryotic cells, yet conventional flow cytometry can hardly meet the sensitivity requirement for nanoscale BPOs. Recent advances in high-sensitivity flow cytometry

    更新日期:2020-04-21
  • Single-Molecule Analysis with Solid-State Nanopores.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Tim Albrecht

    Solid-state nanopores and nanopipettes are an exciting class of single-molecule sensors that has grown enormously over the last two decades. They offer a platform for testing fundamental concepts of stochasticity and transport at the nanoscale, for studying single-molecule biophysics and, increasingly, also for new analytical applications and in biomedical sensing. This review covers some fundamental

    更新日期:2020-04-21
  • Single Nanoparticle Electrochemistry.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Fato Tano Patrice,Kaipei Qiu,Yi-Lun Ying,Yi-Tao Long

    Experimental techniques to monitor and visualize the behaviors of single nanoparticles have not only revealed the significant spatial and temporal heterogeneity of those individuals, which are hidden in ensemble methods, but more importantly, they have also enabled researchers to elucidate the origin of such heterogeneity. In pursuing the intrinsic structure-function relations of single nanoparticles

    更新日期:2020-04-21
  • Advanced Spectroelectrochemical Techniques to Study Electrode Interfaces Within Lithium-Ion and Lithium-Oxygen Batteries.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Alexander J Cowan,Laurence J Hardwick

    Lithium battery technologies have revolutionized mobile energy storage, but improvements in the technology are still needed. Critical to delivering new light weight, high capacity, safe devices is an improved understanding of the dynamic processes occurring at the electrode-electrolyte interfaces. Therefore, alongside advances in materials there has been a parallel progression in advanced characterization

    更新日期:2020-04-21
  • Electrochemistry at the Synapse.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Mimi Shin,Ying Wang,Jason R Borgus,B Jill Venton

    Electrochemical measurements of neurotransmitters provide insight into the dynamics of neurotransmission. In this review, we describe the development of electrochemical measurements of neurotransmitters and how they started with extrasynaptic measurements but now are pushing toward synaptic measurements. Traditionally, biosensors or fast-scan cyclic voltammetry have monitored extrasynaptic levels of

    更新日期:2020-04-21
  • Electrochemiluminescence Imaging for Bioanalysis.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Jingjing Zhang,Stéphane Arbault,Neso Sojic,Dechen Jiang

    Electrochemiluminescence (ECL) is a widely used analytical technique with the advantages of high sensitivity and low background signal. The recent and rapid development of electrochemical materials, luminophores, and optical elements significantly increases the ECL signals and, thus, ECL imaging with enhanced spatial and temporal resolutions is realized. Currently, ECL imaging is successfully applied

    更新日期:2020-04-21
  • Molecular Characterization of Atmospheric Organic Aerosol by Mass Spectrometry.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Murray V Johnston,Devan E Kerecman

    Atmospheric aerosol, particulate matter suspended in the air we breathe, exerts a strong impact on our health and the environment. Controlling the amount of particulate matter in air is difficult, as there are many ways particles can form by both natural and anthropogenic processes. We gain insight into the sources of particulate matter through chemical composition measurements. A substantial portion

    更新日期:2020-04-21
  • Laser Desorption Combined with Laser Postionization for Mass Spectrometry.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Luke Hanley,Raveendra Wickramasinghe,Yeni P Yung

    Lasers with pulse lengths from nanoseconds to femtoseconds and wavelengths from the mid-infrared to extreme ultraviolet (UV) have been used for desorption or ablation in mass spectrometry. Such laser sampling can often benefit from the addition of a second laser for postionization of neutrals. The advantages offered by laser postionization include the ability to forego matrix application, high lateral

    更新日期:2020-04-21
  • Metabolic Imaging at the Single-Cell Scale: Recent Advances in Mass Spectrometry Imaging.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Ian S Gilmore,Sven Heiles,Cornelius L Pieterse

    There is an increasing appreciation that every cell, even of the same type, is different. This complexity, when additionally combined with the variety of different cell types in tissue, is driving the need for spatially resolved omics at the single-cell scale. Rapid advances are being made in genomics and transcriptomics, but progress in metabolomics lags. This is partly because amplification and tagging

    更新日期:2020-04-21
  • Challenges in Identifying the Dark Molecules of Life.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    María Eugenia Monge,James N Dodds,Erin S Baker,Arthur S Edison,Facundo M Fernández

    Metabolomics is the study of the metabolome, the collection of small molecules in living organisms, cells, tissues, and biofluids. Technological advances in mass spectrometry, liquid- and gas-phase separations, nuclear magnetic resonance spectroscopy, and big data analytics have now made it possible to study metabolism at an omics or systems level. The significance of this burgeoning scientific field

    更新日期:2020-04-21
  • Advances in Surface Plasmon Resonance Imaging and Microscopy and Their Biological Applications.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Markéta Bocková,Jiří Slabý,Tomáš Špringer,Jiří Homola

    Surface plasmon resonance microscopy and imaging are optical methods that enable observation and quantification of interactions of nano- and microscale objects near a metal surface in a temporally and spatially resolved manner. This review describes the principles of surface plasmon resonance microscopy and imaging and discusses recent advances in these methods, in particular, in optical platforms

    更新日期:2020-04-21
  • Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Hsien-Wei Yeh,Hui-Wang Ai

    Although fluorescent reporters and biosensors have become indispensable tools in biological and biomedical fields, fluorescence measurements require external excitation light, thereby limiting their use in thick tissues and live animals. Bioluminescent reporters and biosensors may potentially overcome this hurdle because they use enzyme-catalyzed exothermic biochemical reactions to generate excited-state

    更新日期:2020-04-21
  • Recent Developments in Nanosensors for Imaging Applications in Biological Systems.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Guoxin Rong,Erin E Tuttle,Ashlyn Neal Reilly,Heather A Clark

    Sensors are key tools for monitoring the dynamic changes of biomolecules and biofunctions that encode valuable information that helps us understand underlying biological processes of fundamental importance. Because of their distinctive size-dependent physicochemical properties, materials with nanometer scales have recently emerged as promising candidates for biological sensing applications by offering

    更新日期:2020-04-21
  • Whole-Organism Analysis by Vibrational Spectroscopy.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Dale Christensen,Anja Rüther,Kamila Kochan,David Pérez-Guaita,Bayden Wood

    Vibrational spectroscopy has contributed to the understanding of biological materials for many years. As the technology has advanced, the technique has been brought to bear on the analysis of whole organisms. Here, we discuss advanced and recently developed infrared and Raman spectroscopic instrumentation to whole-organism analysis. We highlight many of the recent contributions made in this relatively

    更新日期:2020-04-21
  • Polyvalent Nanoobjects for Precision Diagnostics.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    David T Omstead,Jenna Sjoerdsma,Basar Bilgicer

    As our ability to synthesize and modify nanoobjects has improved, efforts to explore nanotechnology for diagnostic purposes have gained momentum. The variety of nanoobjects, especially those with polyvalent properties, displays a wide range of practical and unique properties well suited for applications in various diagnostics. This review briefly covers the broad scope of multivalent nanoobjects and

    更新日期:2020-04-21
  • Emerging Analytical Techniques for Rapid Pathogen Identification and Susceptibility Testing.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Dong Jin Shin,Nadya Andini,Kuangwen Hsieh,Samuel Yang,Tza-Huei Wang

    In the face of looming threats from multi-drug resistant microorganisms, there is a growing need for technologies that will enable rapid identification and drug susceptibility profiling of these pathogens in health care settings. In particular, recent progress in microfluidics and nucleic acid amplification is pushing the boundaries of timescale for diagnosing bacterial infections. With a diverse range

    更新日期:2020-04-21
  • E-Cigarette Chemistry and Analytical Detection.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Robert M Strongin

    The study of e-cigarette aerosol properties can inform public health while longer-term epidemiological investigations are ongoing. The determination of aerosol levels of known toxins, as well as of molecules with unknown inhalation toxicity profiles, affords specific information for estimating the risks of e-cigarettes and for uncovering areas that should be prioritized for further investigation.

    更新日期:2020-04-21
  • Wearable Sensors for Biochemical Sweat Analysis.
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2019-06-12
    Amay J Bandodkar,William J Jeang,Roozbeh Ghaffari,John A Rogers

    Sweat is a largely unexplored biofluid that contains many important biomarkers ranging from electrolytes and metabolites to proteins, cytokines, antigens, and exogenous drugs. The eccrine and apocrine glands produce and excrete sweat through microscale pores on the epidermal surface, offering a noninvasive means for capturing and probing biomarkers that reflect hydration state, fatigue, nutrition,

    更新日期:2020-04-21
  • Mass Spectrometry for Synthesis and Analysis
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    R. Graham Cooks, Xin Yan

    Mass spectrometry is the science and technology of ions. As such, it is concerned with generating ions, measuring their properties, following their reactions, isolating them, and using them to build and transform materials. Instrumentation is an essential element of these activities, and analytical applications are one driving force. Work from the Aston Laboratories at Purdue University's Department

    更新日期:2018-06-12
  • Gas Cluster Ion Beams for Secondary Ion Mass Spectrometry
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Nicholas Winograd

    Gas cluster ion beams (GCIBs) provide new opportunities for bioimaging and molecular depth profiling with secondary ion mass spectrometry (SIMS). These beams, consisting of clusters containing thousands of particles, initiate desorption of target molecules with high yield and minimal fragmentation. This review emphasizes the unique opportunities for implementing these sources, especially for bioimaging

    更新日期:2018-06-12
  • Technologies for Measuring Pharmacokinetic Profiles
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    A.A. Heller, S.Y. Lockwood, T.M. Janes, D.M. Spence

    The creation of a pharmacokinetic (PK) curve, which follows the plasma concentration of an administered drug as a function of time, is a critical aspect of the drug development process and includes such information as the drug's bioavailability, clearance, and elimination half-life. Prior to a drug of interest gaining clearance for use in human clinical trials, research is performed during the preclinical

    更新日期:2018-06-12
  • Interfacing Cells with Vertical Nanoscale Devices: Applications and Characterization
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Allister F. McGuire, Francesca Santoro, Bianxiao Cui

    Measurements of the intracellular state of mammalian cells often require probes or molecules to breach the tightly regulated cell membrane. Mammalian cells have been shown to grow well on vertical nanoscale structures in vitro, going out of their way to reach and tightly wrap the structures. A great deal of research has taken advantage of this interaction to bring probes close to the interface or deliver

    更新日期:2018-06-12
  • Wearable and Implantable Sensors for Biomedical Applications
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Hatice Ceylan Koydemir, Aydogan Ozcan

    Mobile health technologies offer great promise for reducing healthcare costs and improving patient care. Wearable and implantable technologies are contributing to a transformation in the mobile health era in terms of improving healthcare and health outcomes and providing real-time guidance on improved health management and tracking. In this article, we review the biomedical applications of wearable

    更新日期:2018-06-12
  • SERS Sensors: Recent Developments and a Generalized Classification Scheme Based on the Signal Origin
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Xin Gu, Michael J. Trujillo, Jacob E. Olson, Jon P. Camden

    Owing to its extreme sensitivity and easy execution, surface-enhanced Raman spectroscopy (SERS) now finds application for a wide variety of problems requiring sensitive and targeted analyte detection. This widespread application has prompted a proliferation of different SERS-based sensors, suggesting the need for a framework to classify existing methods and guide the development of new techniques.

    更新日期:2018-06-12
  • DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Dekai Ye, Xiaolei Zuo, Chunhai Fan

    Biosensors represent biomimetic analytical tools for addressing increasing needs in medical diagnosis, environmental monitoring, security, and biodefense. Nevertheless, widespread real-world applications of biosensors remain challenging due to limitations of performance, including sensitivity, specificity, speed, and reproducibility. In this review, we present a DNA nanotechnology-enabled interfacial

    更新日期:2018-06-12
  • DNA Electrochemistry and Electrochemical Sensors for Nucleic Acids
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Elena E. Ferapontova

    Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, and robust tools for the development of such analytical platforms that can successfully compete with other

    更新日期:2018-06-12
  • Improving Lateral Flow Assay Performance Using Computational Modeling
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    David Gasperino, Ted Baughman, Helen V. Hsieh, David Bell, Bernhard H. Weigl

    The performance, field utility, and low cost of lateral flow assays (LFAs) have driven a tremendous shift in global health care practices by enabling diagnostic testing in previously unserved settings. This success has motivated the continued improvement of LFAs through increasingly sophisticated materials and reagents. However, our mechanistic understanding of the underlying processes that drive the

    更新日期:2018-06-12
  • Recent Advances and Trends in Microfluidic Platforms for C. elegans Biological Assays
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Farhan Kamili, Hang Lu

    Microfluidics has proven to be a key tool in quantitative biological research. The C. elegans research community in particular has developed a variety of microfluidic platforms to investigate sensory systems, development, aging, and physiology of the nematode. Critical for the growth of this field, however, has been the implementation of concurrent advanced microscopy, hardware, and software technologies

    更新日期:2018-06-12
  • Fabrication and Use of Nanopipettes in Chemical Analysis
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Shudong Zhang, Mingzhi Li, Bin Su, Yuanhua Shao

    This review summarizes progress in the fabrication, modification, characterization, and applications of nanopipettes since 2010. A brief history of nanopipettes is introduced, and the details of fabrication, modification, and characterization of nanopipettes are provided. Applications of nanopipettes in chemical analysis are the focus in several cases, including recent progress in imaging; in the study

    更新日期:2018-06-12
  • 3D Printed Organ Models for Surgical Applications
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Kaiyan Qiu, Ghazaleh Haghiashtiani, Michael C. McAlpine

    Medical errors are a major concern in clinical practice, suggesting the need for advanced surgical aids for preoperative planning and rehearsal. Conventionally, CT and MRI scans, as well as 3D visualization techniques, have been utilized as the primary tools for surgical planning. While effective, it would be useful if additional aids could be developed and utilized in particularly complex procedures

    更新日期:2018-06-12
  • Analytical Chemistry in the Regulatory Science of Medical Devices
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Yi Wang, Allan Guan, Samanthi Wickramasekara, K. Scott Phillips

    In the United States, regulatory science is the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of all Food and Drug Administration–regulated products. Good regulatory science facilitates consumer access to innovative medical devices that are safe and effective throughout the Total Product Life Cycle (TPLC). Because the need to measure

    更新日期:2018-06-12
  • (Multi)functional Atomic Force Microscopy Imaging
    Annu. Rev. Anal. Chem. (IF 7.023) Pub Date : 2018-06-12
    Anisha N. Patel, Christine Kranz

    Incorporating functionality to atomic force microscopy (AFM) to obtain physical and chemical information has always been a strong focus in AFM research. Modifying AFM probes with specific molecules permits accessibility of chemical information via specific reactions and interactions. Fundamental understanding of molecular processes at the solid/liquid interface with high spatial resolution is essential

    更新日期:2018-06-12
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