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  • Advanced Spectroelectrochemical Techniques to Study Electrode Interfaces Within Lithium-Ion and Lithium-Oxygen Batteries.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-04-30
    Alexander J Cowan,Laurence J Hardwick

    Lithium battery technologies have revolutionized mobile energy storage, but improvements in the technology are still needed. Critical to delivering new light weight, high capacity, safe devices is an improved understanding of the dynamic processes occurring at the electrode-electrolyte interfaces. Therefore, alongside advances in materials there has been a parallel progression in advanced characterization

    更新日期:2019-06-12
  • Single Nanoparticle Electrochemistry.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-04-24
    Fato Tano Patrice,Kaipei Qiu,Yi-Lun Ying,Yi-Tao Long

    Experimental techniques to monitor and visualize the behaviors of single nanoparticles have not only revealed the significant spatial and temporal heterogeneity of those individuals, which are hidden in ensemble methods, but more importantly, they have also enabled researchers to elucidate the origin of such heterogeneity. In pursuing the intrinsic structure-function relations of single nanoparticles

    更新日期:2019-06-12
  • Whole-Organism Analysis by Vibrational Spectroscopy.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-04-12
    Dale Christensen,Anja Rüther,Kamila Kochan,David Pérez-Guaita,Bayden Wood

    Vibrational spectroscopy has contributed to the understanding of biological materials for many years. As the technology has advanced, the technique has been brought to bear on the analysis of whole organisms. Here, we discuss advanced and recently developed infrared and Raman spectroscopic instrumentation to whole-organism analysis. We highlight many of the recent contributions made in this relatively

    更新日期:2019-06-12
  • Flow Cytometric Analysis of Nanoscale Biological Particles and Organelles.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-04-12
    Hong Lian,Shengbin He,Chaoxiang Chen,Xiaomei Yan

    Analysis of nanoscale biological particles and organelles (BPOs) at the single-particle level is fundamental to the in-depth study of biosciences. Flow cytometry is a versatile technique that has been well-established for the analysis of eukaryotic cells, yet conventional flow cytometry can hardly meet the sensitivity requirement for nanoscale BPOs. Recent advances in high-sensitivity flow cytometry

    更新日期:2019-06-12
  • Single-Cell Protein Secretion Detection and Profiling.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-04-12
    Zhuo Chen,Jonathan J Chen,Rong Fan

    Secreted proteins play important roles in mediating various biological processes such as cell-cell communication, differentiation, migration, and homeostasis at the population or tissue level. Here, we review bioanalytical technologies and devices for detecting protein secretions from single cells. We begin by discussing conventional approaches followed by detailing the latest advances in microengineered

    更新日期:2019-06-12
  • Emerging Analytical Techniques for Rapid Pathogen Identification and Susceptibility Testing.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-04-02
    Dong Jin Shin,Nadya Andini,Kuangwen Hsieh,Samuel Yang,Tza-Huei Wang

    In the face of looming threats from multi-drug resistant microorganisms, there is a growing need for technologies that will enable rapid identification and drug susceptibility profiling of these pathogens in health care settings. In particular, recent progress in microfluidics and nucleic acid amplification is pushing the boundaries of timescale for diagnosing bacterial infections. With a diverse range

    更新日期:2019-06-12
  • Electrochemiluminescence Imaging for Bioanalysis.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-04-02
    Jingjing Zhang,Stéphane Arbault,Neso Sojic,Dechen Jiang

    Electrochemiluminescence (ECL) is a widely used analytical technique with the advantages of high sensitivity and low background signal. The recent and rapid development of electrochemical materials, luminophores, and optical elements significantly increases the ECL signals and, thus, ECL imaging with enhanced spatial and temporal resolutions is realized. Currently, ECL imaging is successfully applied

    更新日期:2019-06-12
  • Well-Defined Materials for High-Performance Chromatographic Separation.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-04-02
    Yu Liang,Lihua Zhang,Yukui Zhang

    Chromatographic separation has been widely applied in various fields, such as chemical engineering, precision medicine, energy, and biology. Because chromatographic separation is based on differential partitioning between the mobile phase and stationary phase and affected by band dispersion and mass transfer resistance from these two phases, the materials used as the stationary phase play a decisive

    更新日期:2019-06-12
  • Molecular Characterization of Atmospheric Organic Aerosol by Mass Spectrometry.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-03-22
    Murray V Johnston,Devan E Kerecman

    Atmospheric aerosol, particulate matter suspended in the air we breathe, exerts a strong impact on our health and the environment. Controlling the amount of particulate matter in air is difficult, as there are many ways particles can form by both natural and anthropogenic processes. We gain insight into the sources of particulate matter through chemical composition measurements. A substantial portion

    更新日期:2019-06-12
  • Challenges in Identifying the Dark Molecules of Life.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-03-18
    María Eugenia Monge,James N Dodds,Erin S Baker,Arthur S Edison,Facundo M Fernández

    Metabolomics is the study of the metabolome, the collection of small molecules in living organisms, cells, tissues, and biofluids. Technological advances in mass spectrometry, liquid- and gas-phase separations, nuclear magnetic resonance spectroscopy, and big data analytics have now made it possible to study metabolism at an omics or systems level. The significance of this burgeoning scientific field

    更新日期:2019-06-12
  • Recent Developments in Nanosensors for Imaging Applications in Biological Systems.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-03-11
    Guoxin Rong,Erin E Tuttle,Ashlyn Neal Reilly,Heather A Clark

    Sensors are key tools for monitoring the dynamic changes of biomolecules and biofunctions that encode valuable information that helps us understand underlying biological processes of fundamental importance. Because of their distinctive size-dependent physicochemical properties, materials with nanometer scales have recently emerged as promising candidates for biological sensing applications by offering

    更新日期:2019-06-12
  • E-Cigarette Chemistry and Analytical Detection.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-03-08
    Robert M Strongin

    The study of e-cigarette aerosol properties can inform public health while longer-term epidemiological investigations are ongoing. The determination of aerosol levels of known toxins, as well as of molecules with unknown inhalation toxicity profiles, affords specific information for estimating the risks of e-cigarettes and for uncovering areas that should be prioritized for further investigation.

    更新日期:2019-06-12
  • Metabolic Imaging at the Single-Cell Scale: Recent Advances in Mass Spectrometry Imaging.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-03-08
    Ian S Gilmore,Sven Heiles,Cornelius L Pieterse

    There is an increasing appreciation that every cell, even of the same type, is different. This complexity, when additionally combined with the variety of different cell types in tissue, is driving the need for spatially resolved omics at the single-cell scale. Rapid advances are being made in genomics and transcriptomics, but progress in metabolomics lags. This is partly because amplification and tagging

    更新日期:2019-06-12
  • Advances in Surface Plasmon Resonance Imaging and Microscopy and Their Biological Applications.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-03-01
    Markéta Bocková,Jiří Slabý,Tomáš Špringer,Jiří Homola

    Surface plasmon resonance microscopy and imaging are optical methods that enable observation and quantification of interactions of nano- and microscale objects near a metal surface in a temporally and spatially resolved manner. This review describes the principles of surface plasmon resonance microscopy and imaging and discusses recent advances in these methods, in particular, in optical platforms

    更新日期:2019-06-12
  • Polyvalent Nanoobjects for Precision Diagnostics.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-02-27
    David T Omstead,Jenna Sjoerdsma,Basar Bilgicer

    As our ability to synthesize and modify nanoobjects has improved, efforts to explore nanotechnology for diagnostic purposes have gained momentum. The variety of nanoobjects, especially those with polyvalent properties, displays a wide range of practical and unique properties well suited for applications in various diagnostics. This review briefly covers the broad scope of multivalent nanoobjects and

    更新日期:2019-06-12
  • Wearable Sensors for Biochemical Sweat Analysis.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-02-20
    Amay J Bandodkar,William J Jeang,Roozbeh Ghaffari,John A Rogers

    Sweat is a largely unexplored biofluid that contains many important biomarkers ranging from electrolytes and metabolites to proteins, cytokines, antigens, and exogenous drugs. The eccrine and apocrine glands produce and excrete sweat through microscale pores on the epidermal surface, offering a noninvasive means for capturing and probing biomarkers that reflect hydration state, fatigue, nutrition,

    更新日期:2019-06-12
  • Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-02-20
    Hsien-Wei Yeh,Hui-Wang Ai

    Although fluorescent reporters and biosensors have become indispensable tools in biological and biomedical fields, fluorescence measurements require external excitation light, thereby limiting their use in thick tissues and live animals. Bioluminescent reporters and biosensors may potentially overcome this hurdle because they use enzyme-catalyzed exothermic biochemical reactions to generate excited-state

    更新日期:2019-06-12
  • Laser Desorption Combined with Laser Postionization for Mass Spectrometry.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-02-20
    Luke Hanley,Raveendra Wickramasinghe,Yeni P Yung

    Lasers with pulse lengths from nanoseconds to femtoseconds and wavelengths from the mid-infrared to extreme ultraviolet (UV) have been used for desorption or ablation in mass spectrometry. Such laser sampling can often benefit from the addition of a second laser for postionization of neutrals. The advantages offered by laser postionization include the ability to forego matrix application, high lateral

    更新日期:2019-06-12
  • Electrochemistry at the Synapse.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-02-01
    Mimi Shin,Ying Wang,Jason R Borgus,B Jill Venton

    Electrochemical measurements of neurotransmitters provide insight into the dynamics of neurotransmission. In this review, we describe the development of electrochemical measurements of neurotransmitters and how they started with extrasynaptic measurements but now are pushing toward synaptic measurements. Traditionally, biosensors or fast-scan cyclic voltammetry have monitored extrasynaptic levels of

    更新日期:2019-06-12
  • Single-Molecule Analysis with Solid-State Nanopores.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-02-01
    Tim Albrecht

    Solid-state nanopores and nanopipettes are an exciting class of single-molecule sensors that has grown enormously over the last two decades. They offer a platform for testing fundamental concepts of stochasticity and transport at the nanoscale, for studying single-molecule biophysics and, increasingly, also for new analytical applications and in biomedical sensing. This review covers some fundamental

    更新日期:2019-06-12
  • High-Parameter Single-Cell Analysis.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-01-30
    Pratip K Chattopadhyay,Aidan F Winters,Woodrow E Lomas,Andressa S Laino,David M Woods

    Thousands of transcripts and proteins confer function and discriminate cell types in the body. Using high-parameter technologies, we can now measure many of these markers at once, and multiple platforms are now capable of analysis on a cell-by-cell basis. Three high-parameter single-cell technologies have particular potential for discovering new biomarkers, revealing disease mechanisms, and increasing

    更新日期:2019-06-12
  • Separation Phenomena in Tailored Micro- and Nanofluidic Environments.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-01-30
    Mukul Sonker,Daihyun Kim,Ana Egatz-Gomez,Alexandra Ros

    Separations of bioanalytes require robust, effective, and selective migration phenomena. However, due to the complexity of biological matrices such as body fluids or tissue, these requirements are difficult to achieve. The separations field is thus constantly evolving to develop suitable methods to separate biomarkers and fractionate biospecimens for further interrogation of biomolecular content. Advances

    更新日期:2019-06-12
  • Solving the Structure and Dynamics of Metal Nanoparticles by Combining X-Ray Absorption Fine Structure Spectroscopy and Atomistic Structure Simulations.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-01-30
    J Timoshenko,Z Duan,G Henkelman,R M Crooks,A I Frenkel

    Extended X-ray absorption fine structure (EXAFS) spectroscopy is a premiere method for analysis of the structure and structural transformation of nanoparticles. Extraction of analytical information about the three-dimensional structure and dynamics of metal-metal bonds from EXAFS spectra requires special care due to their markedly non-bulk-like character. In recent decades, significant progress has

    更新日期:2019-06-12
  • Imaging and Analytics on the Helium Ion Microscope.
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2019-01-30
    Tom Wirtz,Olivier De Castro,Jean-Nicolas Audinot,Patrick Philipp

    The helium ion microscope (HIM) has emerged as an instrument of choice for patterning, imaging and, more recently, analytics at the nanoscale. Here, we review secondary electron imaging on the HIM and the various methodologies and hardware components that have been developed to confer analytical capabilities to the HIM. Secondary electron-based imaging can be performed at resolutions down to 0.5 nm

    更新日期:2019-06-12
  • Mass Spectrometry for Synthesis and Analysis
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    R. Graham Cooks, Xin Yan

    Mass spectrometry is the science and technology of ions. As such, it is concerned with generating ions, measuring their properties, following their reactions, isolating them, and using them to build and transform materials. Instrumentation is an essential element of these activities, and analytical applications are one driving force. Work from the Aston Laboratories at Purdue University's Department

    更新日期:2018-06-12
  • Gas Cluster Ion Beams for Secondary Ion Mass Spectrometry
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Nicholas Winograd

    Gas cluster ion beams (GCIBs) provide new opportunities for bioimaging and molecular depth profiling with secondary ion mass spectrometry (SIMS). These beams, consisting of clusters containing thousands of particles, initiate desorption of target molecules with high yield and minimal fragmentation. This review emphasizes the unique opportunities for implementing these sources, especially for bioimaging

    更新日期:2018-06-12
  • Technologies for Measuring Pharmacokinetic Profiles
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    A.A. Heller, S.Y. Lockwood, T.M. Janes, D.M. Spence

    The creation of a pharmacokinetic (PK) curve, which follows the plasma concentration of an administered drug as a function of time, is a critical aspect of the drug development process and includes such information as the drug's bioavailability, clearance, and elimination half-life. Prior to a drug of interest gaining clearance for use in human clinical trials, research is performed during the preclinical

    更新日期:2018-06-12
  • Interfacing Cells with Vertical Nanoscale Devices: Applications and Characterization
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Allister F. McGuire, Francesca Santoro, Bianxiao Cui

    Measurements of the intracellular state of mammalian cells often require probes or molecules to breach the tightly regulated cell membrane. Mammalian cells have been shown to grow well on vertical nanoscale structures in vitro, going out of their way to reach and tightly wrap the structures. A great deal of research has taken advantage of this interaction to bring probes close to the interface or deliver

    更新日期:2018-06-12
  • Wearable and Implantable Sensors for Biomedical Applications
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Hatice Ceylan Koydemir, Aydogan Ozcan

    Mobile health technologies offer great promise for reducing healthcare costs and improving patient care. Wearable and implantable technologies are contributing to a transformation in the mobile health era in terms of improving healthcare and health outcomes and providing real-time guidance on improved health management and tracking. In this article, we review the biomedical applications of wearable

    更新日期:2018-06-12
  • SERS Sensors: Recent Developments and a Generalized Classification Scheme Based on the Signal Origin
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Xin Gu, Michael J. Trujillo, Jacob E. Olson, Jon P. Camden

    Owing to its extreme sensitivity and easy execution, surface-enhanced Raman spectroscopy (SERS) now finds application for a wide variety of problems requiring sensitive and targeted analyte detection. This widespread application has prompted a proliferation of different SERS-based sensors, suggesting the need for a framework to classify existing methods and guide the development of new techniques.

    更新日期:2018-06-12
  • DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Dekai Ye, Xiaolei Zuo, Chunhai Fan

    Biosensors represent biomimetic analytical tools for addressing increasing needs in medical diagnosis, environmental monitoring, security, and biodefense. Nevertheless, widespread real-world applications of biosensors remain challenging due to limitations of performance, including sensitivity, specificity, speed, and reproducibility. In this review, we present a DNA nanotechnology-enabled interfacial

    更新日期:2018-06-12
  • DNA Electrochemistry and Electrochemical Sensors for Nucleic Acids
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Elena E. Ferapontova

    Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, and robust tools for the development of such analytical platforms that can successfully compete with other

    更新日期:2018-06-12
  • Improving Lateral Flow Assay Performance Using Computational Modeling
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    David Gasperino, Ted Baughman, Helen V. Hsieh, David Bell, Bernhard H. Weigl

    The performance, field utility, and low cost of lateral flow assays (LFAs) have driven a tremendous shift in global health care practices by enabling diagnostic testing in previously unserved settings. This success has motivated the continued improvement of LFAs through increasingly sophisticated materials and reagents. However, our mechanistic understanding of the underlying processes that drive the

    更新日期:2018-06-12
  • Recent Advances and Trends in Microfluidic Platforms for C. elegans Biological Assays
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Farhan Kamili, Hang Lu

    Microfluidics has proven to be a key tool in quantitative biological research. The C. elegans research community in particular has developed a variety of microfluidic platforms to investigate sensory systems, development, aging, and physiology of the nematode. Critical for the growth of this field, however, has been the implementation of concurrent advanced microscopy, hardware, and software technologies

    更新日期:2018-06-12
  • Fabrication and Use of Nanopipettes in Chemical Analysis
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Shudong Zhang, Mingzhi Li, Bin Su, Yuanhua Shao

    This review summarizes progress in the fabrication, modification, characterization, and applications of nanopipettes since 2010. A brief history of nanopipettes is introduced, and the details of fabrication, modification, and characterization of nanopipettes are provided. Applications of nanopipettes in chemical analysis are the focus in several cases, including recent progress in imaging; in the study

    更新日期:2018-06-12
  • 3D Printed Organ Models for Surgical Applications
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Kaiyan Qiu, Ghazaleh Haghiashtiani, Michael C. McAlpine

    Medical errors are a major concern in clinical practice, suggesting the need for advanced surgical aids for preoperative planning and rehearsal. Conventionally, CT and MRI scans, as well as 3D visualization techniques, have been utilized as the primary tools for surgical planning. While effective, it would be useful if additional aids could be developed and utilized in particularly complex procedures

    更新日期:2018-06-12
  • Analytical Chemistry in the Regulatory Science of Medical Devices
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Yi Wang, Allan Guan, Samanthi Wickramasekara, K. Scott Phillips

    In the United States, regulatory science is the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of all Food and Drug Administration–regulated products. Good regulatory science facilitates consumer access to innovative medical devices that are safe and effective throughout the Total Product Life Cycle (TPLC). Because the need to measure

    更新日期:2018-06-12
  • (Multi)functional Atomic Force Microscopy Imaging
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Anisha N. Patel, Christine Kranz

    Incorporating functionality to atomic force microscopy (AFM) to obtain physical and chemical information has always been a strong focus in AFM research. Modifying AFM probes with specific molecules permits accessibility of chemical information via specific reactions and interactions. Fundamental understanding of molecular processes at the solid/liquid interface with high spatial resolution is essential

    更新日期:2018-06-12
  • Nano-Enabled Approaches to Chemical Imaging in Biosystems
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Scott T. Retterer, Jennifer L. Morrell-Falvey, Mitchel J. Doktycz

    Understanding and predicting how biosystems function require knowledge about the dynamic physicochemical environments with which they interact and alter by their presence. Yet, identifying specific components, tracking the dynamics of the system, and monitoring local environmental conditions without disrupting biosystem function present significant challenges for analytical measurements. Nanomaterials

    更新日期:2018-06-12
  • Single-Molecule Force Spectroscopy of Transmembrane β-Barrel Proteins
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Johannes Thoma, K. Tanuj Sapra, Daniel J. Müller

    Single-molecule force spectroscopy (SMFS) has been widely applied to study the mechanical unfolding and folding of transmembrane proteins. Here, we review the recent progress in characterizing bacterial and human transmembrane β-barrel proteins by SMFS. First, we describe the mechanical unfolding of transmembrane β-barrels, which follows a general mechanism dictated by the sequential unfolding and

    更新日期:2018-06-12
  • Voltammetric Perspectives on the Acidity Scale and H+/H2 Process in Ionic Liquid Media
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Cameron L. Bentley, Alan M. Bond, Jie Zhang

    Nonhaloaluminate ionic liquids (ILs) have received considerable attention as alternatives to molecular solvents in diverse applications spanning the fields of physical, chemical, and biological science. One important and often overlooked aspect of the implementation of these designer solvents is how the properties of the IL formulation affect (electro)chemical reactivity. This aspect is emphasized

    更新日期:2018-06-12
  • Nanoscale Electrochemical Sensing and Processing in Microreactors
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Mathieu Odijk, Albert van den Berg

    In this review, we summarize recent advances in nanoscale electrochemistry, including the use of nanoparticles, carbon nanomaterials, and nanowires. Exciting developments are reported for nanoscale redox cycling devices, which can chemically amplify signal readout. We also discuss promising high-frequency techniques such as nanocapacitive CMOS sensor arrays or heterodyning. In addition, we review electrochemical

    更新日期:2018-06-12
  • Electrochemical Probes of Microbial Community Behavior
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Hunter J. Sismaet, Edgar D. Goluch

    Advances in next-generation sequencing technology along with decreasing costs now allow the microbial population, or microbiome, of a location to be determined relatively quickly. This research reveals that microbial communities are more diverse and complex than ever imagined. New and specialized instrumentation is required to investigate, with high spatial and temporal resolution, the dynamic biochemical

    更新日期:2018-06-12
  • Boron Doped Diamond: A Designer Electrode Material for the Twenty-First Century
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Samuel J. Cobb, Zoe J. Ayres, Julie V. Macpherson

    Boron doped diamond (BDD) is continuing to find numerous electrochemical applications across a diverse range of fields due to its unique properties, such as having a wide solvent window, low capacitance, and reduced resistance to fouling and mechanical robustness. In this review, we showcase the latest developments in the BDD electrochemical field. These are driven by a greater understanding of the

    更新日期:2018-06-12
  • Recent Advances in Solid-State Nuclear Magnetic Resonance Spectroscopy
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Sharon E. Ashbrook, John M. Griffin, Karen E. Johnston

    The sensitivity of nuclear magnetic resonance (NMR) spectroscopy to the local atomic-scale environment offers great potential for the characterization of a diverse range of solid materials. Despite offering more information than its solution-state counterpart, solid-state NMR has not yet achieved a similar level of recognition, owing to the anisotropic interactions that broaden the spectral lines and

    更新日期:2018-06-12
  • Methods of Measuring Enzyme Activity Ex Vivo and In Vivo
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2018-06-12
    Yangguang Ou, Rachael E. Wilson, Stephen G. Weber

    Enzymes catalyze a variety of biochemical reactions in the body and, in conjunction with transporters and receptors, control virtually all physiological processes. There is great value in measuring enzyme activity ex vivo and in vivo. Spatial and temporal differences or changes in enzyme activity can be related to a variety of natural and pathological processes. Several analytical approaches have been

    更新日期:2018-06-12
  • Single-Cell Transcriptional Analysis
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Angela R. Wu, Jianbin Wang, Aaron M. Streets, Yanyi Huang

    Despite being a relatively recent technological development, single-cell transcriptional analysis through high-throughput sequencing has already been used in hundreds of fruitful studies to make exciting new biological discoveries that would otherwise be challenging or even impossible. Consequently, this has fueled a virtuous cycle of even greater interest in the field and compelled development of

    更新日期:2017-06-12
  • Bioanalytical Measurements Enabled by Surface-Enhanced Raman Scattering (SERS) Probes
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Lauren E. Jamieson, Steven M. Asiala, Kirsten Gracie, Karen Faulds, Duncan Graham

    Since its discovery in 1974, surface-enhanced Raman scattering (SERS) has gained momentum as an important tool in analytical chemistry. SERS is used widely for analysis of biological samples, ranging from in vitro cell culture models, to ex vivo tissue and blood samples, and direct in vivo application. New insights have been gained into biochemistry, with an emphasis on biomolecule detection, from

    更新日期:2017-06-12
  • Applications of Surface Second Harmonic Generation in Biological Sensing
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Renee J. Tran, Krystal L. Sly, John C. Conboy

    Surface second harmonic generation (SHG) is a coherent, nonlinear optical technique that is well suited for investigations of biomolecular interactions at interfaces. SHG is surface specific due to the intrinsic symmetry constraints on the nonlinear process, providing a distinct analytical advantage over linear spectroscopic methods, such as fluorescence and UV-Visible absorbance spectroscopies. SHG

    更新日期:2017-06-12
  • The Solution Assembly of Biological Molecules Using Ion Mobility Methods: From Amino Acids to Amyloid β-Protein
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Christian Bleiholder, Michael T. Bowers

    Ion mobility spectrometry-mass spectrometry (IMS-MS) methods are increasingly used to study noncovalent assemblies of peptides and proteins. This review focuses on the noncovalent self-assembly of amino acids and peptides, systems at the heart of the amyloid process that play a central role in a number of devastating diseases. Three different systems are discussed in detail: the 42-residue peptide

    更新日期:2017-06-12
  • Single-Molecule Arrays for Protein and Nucleic Acid Analysis
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Limor Cohen, David R. Walt

    The last few years have seen breakthroughs that will transform our ability to measure important analytes. Miniaturization of reaction volumes and confinement of analytes of interest into ultrasmall containers have greatly enhanced the sensitivity and throughput of many detection methods. Fabrication of microwell arrays and implementation of bead-based assays have been instrumental in the development

    更新日期:2017-06-12
  • Identification and Quantitation of Circulating Tumor Cells
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Siddarth Rawal, Yu-Ping Yang, Richard Cote, Ashutosh Agarwal

    Circulating tumor cells (CTCs) are shed from the primary tumor into the circulatory system and act as seeds that initiate cancer metastasis to distant sites. CTC enumeration has been shown to have a significant prognostic value as a surrogate marker in various cancers. The widespread clinical utility of CTC tests, however, is still limited due to the inherent rarity and heterogeneity of CTCs, which

    更新日期:2017-06-12
  • Beyond Antibodies as Binding Partners: The Role of Antibody Mimetics in Bioanalysis
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Xiaowen Yu, Yu-Ping Yang, Emre Dikici, Sapna K. Deo, Sylvia Daunert

    The emergence of novel binding proteins or antibody mimetics capable of binding to ligand analytes in a manner analogous to that of the antigen–antibody interaction has spurred increased interest in the biotechnology and bioanalytical communities. The goal is to produce antibody mimetics designed to outperform antibodies with regard to binding affinities, cellular and tumor penetration, large-scale

    更新日期:2017-06-12
  • Raman Imaging in Cell Membranes, Lipid-Rich Organelles, and Lipid Bilayers
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Aleem Syed, Emily A. Smith

    Raman-based optical imaging is a promising analytical tool for noninvasive, label-free chemical imaging of lipid bilayers and cellular membranes. Imaging using spontaneous Raman scattering suffers from a low intensity that hinders its use in some cellular applications. However, developments in coherent Raman imaging, surface-enhanced Raman imaging, and tip-enhanced Raman imaging have enabled video-rate

    更新日期:2017-06-12
  • Analyzing the Heterogeneous Hierarchy of Cultural Heritage Materials: Analytical Imaging
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Karen Trentelman

    Objects of cultural heritage significance are created using a wide variety of materials, or mixtures of materials, and often exhibit heterogeneity on multiple length scales. The effective study of these complex constructions thus requires the use of a suite of complementary analytical technologies. Moreover, because of the importance and irreplaceability of most cultural heritage objects, researchers

    更新日期:2017-06-12
  • Light-Addressable Potentiometric Sensors for Quantitative Spatial Imaging of Chemical Species
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Tatsuo Yoshinobu, Ko-ichiro Miyamoto, Carl Frederik Werner, Arshak Poghossian, Torsten Wagner, Michael J. Schöning

    A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine

    更新日期:2017-06-12
  • Tailored Surfaces/Assemblies for Molecular Plasmonics and Plasmonic Molecular Electronics
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Jean-Christophe Lacroix, Pascal Martin, Pierre-Camille Lacaze

    Molecular plasmonics uses and explores molecule–plasmon interactions on metal nanostructures for spectroscopic, nanophotonic, and nanoelectronic devices. This review focuses on tailored surfaces/assemblies for molecular plasmonics and describes active molecular plasmonic devices in which functional molecules and polymers change their structural, electrical, and/or optical properties in response to

    更新日期:2017-06-12
  • Plasmonic Imaging of Electrochemical Impedance
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Liang Yuan, Nongjian Tao, Wei Wang

    Electrochemical impedance spectroscopy (EIS) measures the frequency spectrum of an electrochemical interface to resist an alternating current. This method allows label-free and noninvasive studies on interfacial adsorption and molecular interactions and has applications in biosensing and drug screening. Although powerful, traditional EIS lacks spatial resolution or imaging capability, hindering the

    更新日期:2017-06-12
  • Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Conggang Li, Jiajing Zhao, Kai Cheng, Yuwei Ge, Qiong Wu, Yansheng Ye, Guohua Xu, Zeting Zhang, Wenwen Zheng, Xu Zhang, Xin Zhou, Gary Pielak, Maili Liu

    Investigating the structure, modification, interaction, and function of biomolecules in their native cellular environment leads to physiologically relevant knowledge about their mechanisms, which will benefit drug discovery and design. In recent years, nuclear and electron magnetic resonance (NMR) spectroscopy has emerged as a useful tool for elucidating the structure and function of biomacromolecules

    更新日期:2017-06-12
  • Coded Apertures in Mass Spectrometry
    Annu. Rev. Anal. Chem. (IF 8.721) Pub Date : 2017-06-12
    Jason J. Amsden, Michael E. Gehm, Zachary E. Russell, Evan X. Chen, Shane T. Di Dona, Scott D. Wolter, Ryan M. Danell, Gottfried Kibelka, Charles B. Parker, Brian R. Stoner, David J. Brady, Jeffrey T. Glass

    The use of coded apertures in mass spectrometry can break the trade-off between throughput and resolution that has historically plagued conventional instruments. Despite their very early stage of development, coded apertures have been shown to increase throughput by more than one order of magnitude, with no loss in resolution in a simple 90-degree magnetic sector. This enhanced throughput can increase

    更新日期:2017-06-12
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