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Single-Laboratory Validation Study of a Rapid TD-NMR method for Quantitation of Total Fat in Sunflower Oil Powder J. AOAC Int. (IF 1.51) Pub Date : 2021-02-19 Isaac Lee; Jennie Vo; Quanyin Gao; Peter Chang; Gary Swanson
A rapid total fat quantitation method for sunflower oil powder was developed using time domain nuclear magnetic resonance (TD-NMR). Currently, industry has three major methods for the total fat quantitation: gravimetric analysis after ether extraction (AOAC 933.05 and 989.05), gas chromatography with flame ionization detector (GC-FID AOAC 996.06), and high resolution NMR. The gravimetric analysis method
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Analytical study of the antifungal posaconazole in raw material: quantitative bioassay, decomposition chemical kinetics and degradation impurities by LC-QTOF-MS. J. AOAC Int. (IF 1.51) Pub Date : 2021-01-20 Cássia V Garcia; Andressa S Bitencourt; Sendy S Oliveira; Caren Gobetti; Andreas S L Mendez
Posaconazole is a triazole antifungal drug approved by FDA in 2006. No bioassay is available in literature or official codes for potency determination in bulk.
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Co-pigmentation of caffeic acid and catechin on wine color and the effect of ultrasound in model wine solutions J. AOAC Int. (IF 1.51) Pub Date : 2020-12-22 Zhen-Dan Xue; Qing-An Zhang; Ting-Ting Wang
Wine color is usually considered to be one of the important indicators to judge the red wine quality, and is also employed to evaluate the wine ageing, while the wine color can be influenced by many factors.
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Screening of 154 Veterinary Drug Residues in Foods of Animal Origin Using LC-MS/MS, First Action 2020.04 J. AOAC Int. (IF 1.51) Pub Date : 2020-12-22 Aurélien Desmarchelier; Thomas Bessaire; Marie-Claude Savoy; Adrienne Tarres; Claudia Mujahid; Andrea Beck; Pascal Mottier; Thierry Delatour
Veterinary drug residues in food are substances (>200 compounds) exhibiting potential health risks for consumers, thus being regulated in national legislations and the Codex Alimentarius. Most of the compounds are regulated based upon a maximum residue limit (MRL) while a few of them are banned in food for humans. The food sector needs a reliable and consensus analytical platform able to monitor these
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Simultaneous analytical efficiency evaluation using HPTLC method for analysis of syringicacid and vanillic acid and their anti-oxidant capacity from methanol extract of Ricinus communis Linn. and Euphorbia hirta Linn J. AOAC Int. (IF 1.51) Pub Date : 2020-12-22 Pradeep Singh; Muhammad Arif; Abdul Qadir; Pushpendra Kannojia
Well-known medicinal plants Ricinus communis Linn. and Euphorbia hirta Linn. have been traditionally used to treat a variety of ailments in the India and other countries.
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Validation and optimization of qPCR method for identification of Actaea Racemosa (Black cohosh) NHPs J. AOAC Int. (IF 1.51) Pub Date : 2020-12-21 Jeevitha Shanmughanandhan; Dhivya Shanmughanandhan; Subramanyam Ragupathy; Thomas A Henry; Steven G Newmaster
Actaea racemosa (Black cohosh) herbal dietary supplements are commonly used to treat menopausal symptoms in women. However, there is a considerable risk of contamination of A. racemosa herbal products in the natural health product (NHP) industry, impacting potential efficacy. Authentication of A. racemosa products is challenging because of the standard, multi-part analytical chemistry methods that
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Impact Study of Mathematical Manipulation on the Resolution Efficiency of the Spectrophotometric Technique—An Application on Veterinary Binary Mixture with Overlapping Absorption Bands J. AOAC Int. (IF 1.51) Pub Date : 2020-08-13 Hayam M Lotfy; Hany H Monir; Adel M Michael; Yasmin M Fayez; Christine K Nessim
The impact of mathematical manipulation on the efficiency of smart spectrophotometric approaches was considered for analyzing a veterinary binary mixture of tylosin tartrate (TYT) and doxycycline hydrochloride (DOX).
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Determination of Rufinamide in the Presence of 1-[(2,6-Difluorophenyl)Methyl]-1H-1,2,3-Triazole-4 Carboxylic Acid Using RP-HPLC and Derivative Ratio Methods as Stability Indicating Assays to Be Applied on Dosage Form J. AOAC Int. (IF 1.51) Pub Date : 2020-07-26 Sonia T Hassib; Hanaa M A Hashem; Marianne A Mahrouse; Eman A Mostafa
Rufinamide is a triazole derivative that is structurally dissimilar to other marketed antiepileptic drugs, has been assumed a marketing authorization, by the European Union and FDA, for use as a complementary therapy for seizures associated with Lennox-Gastaut syndrome.
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Investigation of cytotoxic constituents from seed-pulp of Entada Phaseoloides and metabolite profiling using UPLC-QTOF-MSE J. AOAC Int. (IF 1.51) Pub Date : 2020-09-30 P Pavan Kumar; Bandi Siva; Kumar Katragunta; Supriya D Beedkar; Sistla Ramakrishna; Chandana C Barua; K Suresh Babu
Entada phaseoloides (Linn.) Merr. (Family: Fabaceae), is a well-known traditional medicinal plant and has been extensively used in Ayurvedic system of medicine for centuries to combat wide range of ailments.
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Application of MEKC and UPLC with fluorescence detection for simultaneous determination of amlodipine besylate and bisoprolol fumarate J. AOAC Int. (IF 1.51) Pub Date : 2020-09-30 Sohila M Elonsy; Fawzy A El Yazbi; Rasha A Shaalan; Hytham M Ahmed; Tarek S Belal
Two chromatographic methods were described for simultaneous determination of the antihypertensive drugs amlodipine besylate (AML) and bisoprolol fumarate (BIS).
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Quantitative Determination of AZD3264, a Selective IkB-kinase IKK2 Inhibitor, in Dog Plasma by Solvent Induced Phase Transition Extraction Coupled with HPLC-MS/MS and its Application to Pharmacokinetic Study in Dogs J. AOAC Int. (IF 1.51) Pub Date : 2020-09-30 Gang LI; Shuofu Liang; Kesen Qiao; Chao Wang
AZD3264 is a small molecule inhibitor of selective IkB-kinase IKK2 currently in preclinical development for the potential treatment of asthma and COPD.
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Comparative Profiling of Four Lignans Phyllanthin, Hypophyllanthin, Nirtetralin and Niranthin in Nine Phyllanthus Species from India Using a Validated Reversed Phase HPLC-PDA Detection Method J. AOAC Int. (IF 1.51) Pub Date : 2020-09-30 Jinal Patel; Padamnabhi Singh Nagar; Kalpana Pal; Raghuraj Singh; Tushar Dhanani; Vyomesh Patel; Sharad Srivatava; Satyanshu Kumar
Despite exhibiting wide range of in vitro and in vivo pharmacological activities by many Phyllanthus species, little is known about the compounds present in the extracts that are responsible for those actions.
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Arsenic and Lead Determination in D&C Red No. 6 Lakes and D&C Red No. 7 Lakes Containing Barium Sulfate Using X-Ray Fluorescence Spectrometry J. AOAC Int. (IF 1.51) Pub Date : 2020-09-27 Hepp N.
Abstract BackgroundColor additives requiring batch certification by the U.S. Food and Drug Administration have Code of Federal Regulations (CFR) specification limits for certain elements and are usually analyzed by x-ray fluorescence spectrometry (XRF). However, analysis of some color additives presents difficulties. ObjectiveAn XRF method was developed for quickly determining whether barium sulfate-containing
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Validation of the SafTest Percent Fat for the Measurement of the Fat Content of Meat Meals, Fish Meal and Potato Chips, Crackers and Other and Grain-Based Snack J. AOAC Int. (IF 1.51) Pub Date : 2020-09-26 Virginia C Gordon I; Christopher C Rainey; Willainia C Studmire
The Official American Oil Chemists Society (AOCS) Standard Procedure Aa 4-38, AOCS Standard Procedure Am 5-04, ISO 11085:2015 and similar methods are based on extraction of fats from food products using organic solvents. These methods require large volumes of organic solvents and up to 18-hour extractions. The SafTest Percent Fat measures fat content as “total triglycerides” in solubilized snack products
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Determination of ethanol concentration in Kombucha beverages: Single-Laboratory Validation of an enzymatic method, First Action Method 2019.08 J. AOAC Int. (IF 1.51) Pub Date : 2020-09-26 Ruth Ivory; Elaine Delaney; David Mangan; Barry V McCleary
The Ethanol Assay Kit is an enzymatic test kit developed by Megazyme for the determination of ethanol in a variety of samples. The kit has been validated in a single laboratory for use with Kombucha fermented drinks, fruit juices and low-alcohol beer samples. The commercially available Ethanol Assay Kit (Megazyme catalogue no. K-ETOH) contains all components required for the analysis. Quantification
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Single-Laboratory Validation for the Determination of Cocoa Flavanols And Procyanidins (by Degree of Polymerization DP1-7) in Cocoa Based Products by Hydrophilic Interaction Chromatography Coupled with Fluorescence Detection: First Action 2020.05 J. AOAC Int. (IF 1.51) Pub Date : 2020-09-26 Ugo Bussy; Gregory Hewitt; Yusuf Olanrewaju; Brian R May; Nicholas Anderson; Javier Ottaviani; Catherine Kwik-Uribe
Flavanols and procyanidins are complex bioactives found in many foods like cocoa. As their consumption is associated with health benefits, cocoa flavanols and procyanidins are receiving increasing attention from consumers, industry, researchers, and regulators.
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A rapid and accurate 1H NMR method for the identification and quantification of major constituents in Qishen Yiqi Dripping Pills J. AOAC Int. (IF 1.51) Pub Date : 2020-09-26 Qingling Xie; Limin Gong; Feibing Huang; Mengru Cao; Yongbei Liu; Hanwen Yuan; Bin Li; Yuqing Jian; Caiyun Peng; Shuiping Zhou; Yang Chu; Wei Wang
QishenYiqi dripping pills (QSYQ), composed of four herbal medicines including Salvia miltiorrhiza, Astragalus membranaceus, Panax notoginseng and Dalbergiaodorifera, is widely used to treat ischemic cerebrovascular and hemorrhagic cerebrovascular.
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Response surface methodology for spectrophotometric determination of two β-adrenergic agonists-terbium chemosensors in urine and pharmaceutical dosage forms J. AOAC Int. (IF 1.51) Pub Date : 2020-09-25 Marwa Sakr; Marwa Fouad; Rasha Hanafi; Hala Al-Easa; Samir El-Moghazy
According to literature reports, none of the previous methods of analysis had touched the multivariate approach for the quantification of significant factors affecting the interaction of dobutamine or hexoprenaline with Terbium.
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Simultaneous Quantification of Betulinic acid, Lupeoland β –Sitosterolin Madhuca longifolia MethanolicExtract of Bark by Liquid Chromatography-Tandem Mass Spectrometric Method J. AOAC Int. (IF 1.51) Pub Date : 2020-09-21 Veena S Patel; Usmangani K Chhalotiya; Sandip B Patel; Jivani Nuruddin
Liquid chromatography with tandem mass spectrometry is used widely used for the quantitative analysis of phytoconstituents present in medicinal plants to assess the quality of extract used for different investigations. A sensitive, precise, and accurate liquid chromatographic method with tandem mass spectrometric detection was developed for simultaneous quantification of lupeol, betulinic acid, and
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Development of an Assay to Determine the Amount of Ca-Fatty Acid Soaps in Faeces J. AOAC Int. (IF 1.51) Pub Date : 2020-09-09 Natascha Stroebinger; Shane M Rutherfurd; Sharon J Henare; Paul J Moughan
The quantification of faecal Ca-fatty acid soaps is important to understand how fatty acids behave in the gastrointestinal tract.
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Next generation of LFD testing – Smartphone-based Mycotoxin analysis with RIDA®SMART APP J. AOAC Int. (IF 1.51) Pub Date : 2020-09-09 Kai Pumpa; Markus Lacorn; Michael Mättner; David Steinmann; Jasmin Wolf
The RIDA®SMART APP is a smartphone application, which was developed as a quantitative and fast on-site/on-field tool for mycotoxin analyses. Typical operational locations are grain mills, feed mills, ethanol plants, flour producers, but also mobile laboratory services that analyze the grain during harvest in the field. Due to the smartphone-based application there are several advantages. It is a small
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Evaluation of the GENE-UP ® Listeria spp. Method for the Detection of Listeria Species in a Variety of Foods and Select Environmental Surfaces: Collaborative Study, First Action 2019.10 J. AOAC Int. (IF 1.51) Pub Date : 2020-09-09 Ronald Johnson; John Mills; Jean-Louis Pittet; Olivier Mathia; Patrick Bird; Maria Nelson
The GENE-UP®Listeria spp. 2 (LIS 2) assay (Performance Tested MethodSM 121803) is a real-time PCR molecular detection method for the rapid detection of Listeria species (Listeria monocytogenes, L. innocua, L. ivanovii, L. seeligeri and L. welshimeri) in a variety of foods and environmental surfaces.
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Determination of Free Bisphenol A in Commercially Packaged Ready to Consume Carbonated/Non-carbonated and Non-alcoholic Beverages with Immunoaffinity Column Purification and UPLC with Fluorescence Detector First Action Method 2019.07 J. AOAC Int. (IF 1.51) Pub Date : 2020-09-03 Jianmin Liu; Justine Yu; Danrey Toth; Jinchuan Yang; Lingyun Chen
Bisphenol A (BPA) is a chemical of concern in food industry. There is need for sensitive analytical method for determination of BPA in beverages.
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Determination of total proteinogenic amino acids and taurine by pre-column derivatisation and UHPLC: Single Laboratory Validation, First Action 2019.09 J. AOAC Int. (IF 1.51) Pub Date : 2020-09-03 George Joseph; Asha Varughese; Ann Daniel
A method has been developed and validated for selective, accurate and precise determination of total proteinogenic amino acids and taurine from Infant Formula and Adult/Pediatric Nutritional Formulas (powders, ready-to-feed liquids, and liquid concentrates). The method was reviewed by the AOAC INTERNATIONAL SPIFAN Expert Review Panel (ERP) during the 133rd AOAC Annual Meeting & Expo on September 7
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Determination and dietary intake risk assessment of pesticide residues in Fritillariae Thunbergii Bulbs and cultivated soils J. AOAC Int. (IF 1.51) Pub Date : 2020-09-02 Qianke Zhang; Qiqing Ge; Zihan Zhang; Jiajin Song; Shiyu Chen; Houpu Zhang; Yunlong Yu; Bizeng Mao; Hua Fang
Pesticide residues in traditional Chinese medicines pose a potential risk to human health. However, little is known about the characteristics of pesticide residues in the fritillariae thunbergii bulbs (FTB).
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Validation of the Legionella pneumophila SG1 DETECT Kit for Quantification of Legionella pneumophila Serogroup 1 Bacteria in Potable Waters, Process Waters and Surface Waters: AOAC Performance Tested MethodSM 052002 J. AOAC Int. (IF 1.51) Pub Date : 2020-09-02 Hans-Anton Keserue; Nathalie Cornillie; Anna-Katharina Ehlert; Dominic C Mills; Damien Morger; Andrea Piffaretti; Daniel F Schaffhauser; Irène I Schwyzer
The L.p.SG1 DETECT Kit is a rapid, quantitative method for the detection and enumeration of Legionella pneumophila serogroup 1 (L.p. SG1) bacteria from different water matrixes. The method is based on a combination of immunomagnetic separation (IMS) and flow cytometric (FCM) quantification. To this end, the method employs magnetic particles conjugated to anti-L.p. SG1 antibodies for the IMS of the
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Simultaneous preconcentration and spectrophotometric determination of two colorants (E110 and E133) in some foodstuffs using a new mussel-inspired adsorbent J. AOAC Int. (IF 1.51) Pub Date : 2020-09-02 Abdullah Taner Bişgin; Zeynep Nalvuran; Orhan Gezici
A naturally occurring material, namely the sporopollenin (SP), was subjected to an easy physical surface modification process called a polydopamine coating. The treatment changed the acid-base properties of the surface, so that in the new form, the SP surface gained a very attractive character for anionic dyes.
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Sources of Random Variation of Pesticide Residue Analytical Results J. AOAC Int. (IF 1.51) Pub Date : 2020-09-02 Árpád Ambrus; Kata Kerekes; Henriet Szemánné-Dobrik; Zsuzsanna Domák
Pesticide residues are analyzed in thousands of samples yearly by national authorities and private laboratories. Intensive research is ongoing to develop new methods or improve existing ones concentrating on the extraction, cleanup, and detection techniques. Little attention has been paid to the contribution of prior steps in the determination process to the overall laboratory sampling error, though
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Near Infrared Reflectance Spectroscopy Coupled to Chemometrics as a Cost-Effective, Rapid and Non-Destructive Tool for Fish Fraud Control: Monitoring Source, Condition and Nutritional Value of Five Common Whitefish Species J. AOAC Int. (IF 1.51) Pub Date : 2020-08-25 Diogo B Gonçalves; Carla S P Santos; Teresa Pinho; Rafael Queirós; Pedro D Vaz; Mark Bloore; Paolo Satta; Zoltán Kovács; Susana Casal; Isabel Hoffmann
Fish fraud is a problematic issue for the industry that to be properly addressed requires the use of accurate, rapid and cost-effective tools. In this work, near infrared reflectance spectroscopy (NIRS) was used to predict nutritional values (protein, lipids and moisture) as well as to discriminate between source (farmed vs. wild fish) and condition (fresh, defrosted or frozen fish). Five whitefish
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Overview of Portable Assays for the Detection of Mycotoxins, Allergens and Sanitation Monitoring J. AOAC Int. (IF 1.51) Pub Date : 2020-08-25 Ronald W Sarver; David J Almy; Eric R Bergeron; Benjamin F Strong; Brent A Steiner; Robert Donofrio; Anthony J Lupo; R Lucas Gray; Amanda K Sperry
Many food recalls are related to the presence of undeclared allergens and microorganisms in food products. To reduce these occurrences, portable diagnostic assay kits are available to quantitate mycotoxins, detect allergens and gluten in foods and on environmental surfaces and for sanitation monitoring.
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Non-destructive measurement of the internal quality of citrus fruits using a portable NIR device J. AOAC Int. (IF 1.51) Pub Date : 2020-08-25 Carla S P Santos; Rebeca Cruz; Diogo B Gonçalves; Rafael Queirós; Mark Bloore; Zoltán Kovács; Isabel Hoffman; Susana Casal
Citrus industry has grown exponentially as a result of increasing demand on its consumption making it stand high among other fruit crops. Therefore, the citrus sector seeks rapid, ease and non-destructive approaches to evaluate in real-time and in situ the external and internal changes in physical and nutritional quality at any stage of fruit development or storage. In particular, vitamin C is among
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Fibrous g-C3N4@TiO2 Nanocomposites-Based Dispersive Micro-solid Phase Extraction for Chromium Speciation in Cow Milk by ICP-MS after Digestion Treatment with Artificial Gastric Juice J. AOAC Int. (IF 1.51) Pub Date : 2020-08-21 Shizhong Chen; Yuxiu Liu; Juntao Yan; Chunlei Wang; Dengbo Lu
Chromium is an interest element because its toxicity depends on its speciation. Thus, knowledge of Cr speciation in cow milk is essential to human health.
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Application of mid-infrared portable spectrometer for the rapid determination of trans-fatty acid content in lipid extracts of snack and bakery products J. AOAC Int. (IF 1.51) Pub Date : 2020-08-21 Mei-Ling Shotts; Marcal Plans; Kevin Wong; Alex M Milligan; Didem P Aykas; Luis E Rodriguez-Saona
In 2015, the US Food and Drug Administration passed a ban on the “generally recognized as safe” status of partially hydrogenated oils (PHOs), and in June 2018, PHOs were prohibited from being used. Our objective was to develop a predictive model to quantify trans-fat concentrations in bakery and snacks products using a portable mid-infrared (MIR) spectrometer. The approach was tested using 24 calibration
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Food Fingerprinting: Using a two-tiered approach to monitor and mitigate food fraud in rice J. AOAC Int. (IF 1.51) Pub Date : 2020-08-19 Terence F McGrath; Maeve Shannon; Olivier P Chevallier; Ratnasekhar Ch; Fei Xu; Fanzhou Kong; Hong Peng; Ernest Teye; Selorm Akaba; Di Wu; Libiao Wu; Qiang Cai; Le Nguyen Doan Duy; Le Van Viet Man; Sufyan Pandor; Arun P Kapil; Guangtao Zhang; Mary McBride; Christopher T Elliott
Rice is an important staple food that is consumed around the world. Like many foods, the price of rice varies considerably, from very inexpensive for low-quality product to premium pricing for highly prized varieties from specific locations. Therefore, like other foods it is vulnerable to economically motivated adulteration through substitution or misrepresentation of inferior quality rice for more
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Single Laboratory Validation of UHPLC-MS/MS Assays for Six Milk Thistle Flavonolignans in Human Serum J. AOAC Int. (IF 1.51) Pub Date : 2020-08-19 Ruth N Muchiri; Richard B van Breemen
Extracts of milk thistle, Silybum marianum (L.) Gaertn., are used as dietary supplements for their hepatoprotective, anti-inflammatory and anti-tumor activities.
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A simple and standardized method for the determination of total solanesol in potato leaves and its extracts based on HPLC-MS J. AOAC Int. (IF 1.51) Pub Date : 2020-08-17 Tao Lan; Congcong Yu; Ren Li; Zheng Ma; Xingjun Xi; Qiao Chu
Solanesol is an important pharmaceutical intermediate raw material, mainly used to synthesize coenzyme Q10, vitamin K2. It can be found prominent in potato stems and leaves. But now potato stems and leaves are always abandoned or discarded as they are not suitable for use as feed in aquaculture or other purposes. These agricultural waste resources can be reutilized as the corresponding extracts.
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ECOLOGICAL AND MINIATURIZED BIOLOGICAL METHOD FOR ANALYSIS OF DAPTOMYCIN POTENCY J. AOAC Int. (IF 1.51) Pub Date : 2020-08-17 Jessica Freitas Richardi; Ana Carolina Kogawa; Eliane Gandolpho Tótoli Belavenuto; Marlus Chorilli; Hérida Regina Nunes Salgado
Physicochemical and microbiological methods are found in the literature for the analysis of daptomycin, an antimicrobial.
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A new green in situ effervescent CO2-table induce switchable hydrophilicity solvent extraction method of rhodamine B in food and soft drink samples J. AOAC Int. (IF 1.51) Pub Date : 2020-08-10 Naeemullah Khan; Mustafa Tuzen
A new and simple effervescent CO2-table induce switchable hydrophilicity solvent extraction method (CI-SHS) was used for the preconcentration of rhodamine B.
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Free radical scavenging activity of some legumes hulls extract and its efficacy on oil oxidative stability J. AOAC Int. (IF 1.51) Pub Date : 2020-08-10 Alaa ElDein El-Beltagy; Salman Al Harthi
Synthetic antioxidants had toxigenic effects, a growing interest focused on substituting it by natural ones. Attention focused to extract it from the agricultural industries residual to minimize its costs. Legumes seeds hull could be cheap sources of such natural antioxidants.
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GC-MS Analysis of Phthalates and Di-(2-ethylhexyl) Adipate in Canadian Human Milk for Exposure Assessment of Infant Population J. AOAC Int. (IF 1.51) Pub Date : 2020-08-10 Xu-Liang Cao; Melissa Sparling; Wendy Zhao; Tye E Arbuckle
Although more information has become available on the occurrence of phthalates and di(2-ethylhexyl) adipate (DEHA) in foods including cow’s milk, information on their presence in human milk, the important and recommended sole diet for infants up to six months of age, is very limited, especially for DEHA.
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Evaluation and comparison of bioactive constituents of Artemisiae argyi Folium collected at different developmental stages J. AOAC Int. (IF 1.51) Pub Date : 2020-08-10 Dan Zhang; Limin Yao; Yaqing Chang; Guiya Yang; Zijing Xue; Lei Wang; Yuguang Zheng; Long Guo
Artemisiae argyi Folium has been used as herbal medicine and food supplement in China and other Asian countries. There is no report about whether the different developmental stages can influence the bioactive compositions of Artemisiae argyi Folium.
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Identification of A-type proanthocyanidins in cranberry-based foods and dietary supplements by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, First Action Method: 2019.05 J. AOAC Int. (IF 1.51) Pub Date : 2020-08-10 Daniel Esquivel-Alvarado; Emilia Alfaro-Viquez; Christian G Krueger; Martha M Vestling; Jess D Reed
Cranberry proanthocyanidins (c-PAC) are oligomeric structures of flavan-3-ol units, which possess A-type interflavan bonds. c-PAC differs from other botanical sources because other PAC mostly have B-type interflavan bonds. Cranberry products used to alleviate and prevent urinary tract infections may suffer from adulteration, where c-PAC are replaced with less expensive botanical sources of PAC that
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Determination of Ethanol Content in Kombucha using Headspace Gas Chromatography with Mass Spectrometry Detection: Single-Laboratory Validation J. AOAC Int. (IF 1.51) Pub Date : 2020-08-06 Michael Chan; Hong Sy; Jamie Finley; Jake Robertson; Paula N Brown
Kombucha is a fermented beverage made with tea, sugar, and a symbiotic colony of bacteria and yeast (SCOBY) that is usually marketed as a non-alcoholic beverage. Products must contain <0.5% and <1.1% alcohol by volume (ABV) in the United States and Canada respectively to be classified as non-alcoholic products. Prior studies have found that Kombucha beverages can become very acidic and may contain
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Exploring the extra-virgin olive oil volatilome by adding extra dimensions to comprehensive two-dimensional gas chromatography and time of flight mass spectrometry featuring tandem ionization: validation of ripening markers in headspace linearity conditions J. AOAC Int. (IF 1.51) Pub Date : 2020-08-05 Federico Stilo; Erica Liberto; Stephen E Reichenbach; Qingping Tao; Carlo Bicchi; Chiara Cordero
Comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GC×GC-TOF MS) is the most informative analytical approach for chemical characterization of the complex food volatilome. Key analytical features include: separation power and resolution enhancement; improved sensitivity; and structured separation patterns from chemically correlated analytes.
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Appendix Q: Recommendations for Developing Molecular Assays for Microbial Pathogen Detection Using Modern In Silico Approaches J. AOAC Int. (IF 1.51) Pub Date : 2020-07-30 John SantaLucia; Shanmuga Sozhamannan; Jason D Gans; Jeffrey W Koehler; Ricky Soong; Nancy J Lin; Gary Xie; Victoria Olson; Kristian Roth; Linda Beck
We describe the use of in silico approaches to improve the process of molecular assay development and reduce time and cost by utilizing available databases of whole genome pathogen sequences combined with modern bioinformatics and physical modeling tools. Well-characterized assays are needed for accurately detecting pathogens in environmental and patient samples and also for evaluation of the efficacy
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Validation of the Reveal® 3-D for Peanut Lateral Flow Test: AOAC Performance Tested MethodSM 111901 J. AOAC Int. (IF 1.51) Pub Date : 2020-07-23 Quynh-Nhi Le; Alexis Vance; Nawal Bakir; Dave Almy; Emily Slenk; Brooke Roman; Nicole Klass; Benjamin Bastin; Robert Donofrio
Reveal® 3-D for Peanut is an immunochromatographic, lateral flow test for qualitative detection of peanut residue in food manufacturing and food preparation settings. The test can detect low ppm levels of peanut in clean-in-place (CIP) rinses and in swabs from environmental surfaces and can serve as a tool in managing allergen risk.
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RP-HPLC Method for the Simultaneous Determination of a Quaternary Mixture of Propyphenazone, Flavoxate HCl and Two of Their Official Impurities with Dissolution Profiling of Their Tablets J. AOAC Int. (IF 1.51) Pub Date : 2020-07-08 Nariman A El-Ragehy; Nesrin K Ramadan; Mona T Ragab; Badr A El-Zeany
Determination of different drugs in the presence of their impurities is now receiving attention from regulatory authorities such as the ICH and the United States Food and Drug Administration (USFDA).
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Comparison of Different Culture Methods for the Detection of Bacillus cereus Group in Cosmetics J. AOAC Int. (IF 1.51) Pub Date : 2020-06-30 Nadine Yossa; Son T Hoang; Travis Canida; Rebecca Bell; Sandra Tallent; Eric Brown; Thomas Hammack
The U.S. Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) reference culture method uses Modified Letheen Broth (MLB) for microbiological analyses for all types of cosmetic products.
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Single-Laboratory Validation Study of a Proton NMR Method for the Determination of L-Arginine, L-Citrulline, and Taurine Contents in Dietary Supplements J. AOAC Int. (IF 1.51) Pub Date : 2020-06-24 Isaac Lee; Jennie Vo; Quanyin Gao; Piyush Purohit; Veronica Zarraga; Silva Babajanian; Peter Chang; Gary Swanson
A quantitative NMR (qNMR) method can provide rapid analysis compared to chromatographic methods. Sample preparation steps are relatively simpler and run time is shorter. Rapid analysis methods for release tests in quality control laboratories are very important for laboratory efficiency. Here, we describe a single-laboratory validation study for a rapid qNMR analysis of L-arginine, L-citrulline, and
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Phenolic Substances in Foods and Anticarcinogenic Properties: A Public Health Perspective J. AOAC Int. (IF 1.51) Pub Date : 2020-06-24 Pasqualina Laganà; Maria Anna Coniglio; Marco Fiorino; Amélia Martins Delgado; Nadia Chammen; Manel Issaoui; Maria E Gambuzza; Candela Iommi; Luca Soraci; Moawiya A Haddad; Santi Delia
The interest in polyphenols from vegetable sources has been progressively increased because of the demonstrated correlation between their abundance in certain foods or food preparations of traditional importance and heritage, and the answer of anti-inflammatory strategies in hospitalized patients in the presence of polypehnol-rich foods (as a complementary therapy). Consequently, research involving
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Appendix P: Guidance for Soil Collection, Characterization, and Application for Biothreat Agent Detection Method and Site Evaluations J. AOAC Int. (IF 1.51) Pub Date : 2020-06-24 Sharon Brunelle
To provide guidance on standardization of practices for the collection, characterization, and use of soil as a sample matrix or potentially interfering substance in biothreat agent detection applications.
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Chromatographic Methods for the Determination of Aminexil, Pyridoxine, and Niacinamide in a Novel Cosmetic Hair Preparation J. AOAC Int. (IF 1.51) Pub Date : 2020-06-24 Mamdouh R Rezk; Hebatallah M Essam; Enas A Amer; Dina M S Youssif
Aminexil, a new compound patented by L’Oreal, has a stimulating effect on human keratin fibers. Pyridoxine HCl and niacinamide are added to boost the hair tonic effect of aminexil.
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Review of New Trends in the Analysis of Allergenic Residues in Foods and Cosmetic Products J. AOAC Int. (IF 1.51) Pub Date : 2020-06-23 Tomasz Tuzimski; Anna Petruczynik
Allergies represent an important health problem in industrialized countries. Allergen sensitization is an important risk factor for the development of allergic diseases; thus, the identification of an individual’s allergen sensitization is essential for the diagnosis and treatment of diseases.
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Simultaneous Determination of Total Vitamins B1, B2, B3, and B6 in Infant Formula and Related Nutritionals by Enzymatic Digestion and LC-MS/MS—A Multi-Laboratory Testing Study Final Action: AOAC Method 2015.14 J. AOAC Int. (IF 1.51) Pub Date : 2020-06-04 Sean McClure
A multi-laboratory study was completed for AOAC First Action Method 2015.14. Ten laboratories from eight countries participated. Each laboratory analyzed (in duplicate) a placebo and 14 fortified nutritionals. Product matrices analyzed included milk, soy, partially hydrolyzed milk, partially hydrolyzed soy, and elemental-based infant formula powders, milk based infant formula ready-to-feed liquids
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Validated Stability Indicating Chromatographic Methods for Quantification of Imidocarb Dipropionate; Application for the Determination of Its Residues in Bovine Meat and Milk Samples J. AOAC Int. (IF 1.51) Pub Date : 2020-06-04 Ghada AbdElHamid Sedik; Doha Mohamed Naguib; Fahima Morsy; Hala Elsayed Zaazaa
Imidocarb dipropionate (IMD) is an immunomodulator agent commonly used for treatment of anaplasmosis in cattle.
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A Green HPLC Method for Determination of Nine Sulfonamides in Milk and Beef, and Its Greenness Assessment with Analytical Eco-Scale and Greenness Profile J. AOAC Int. (IF 1.51) Pub Date : 2020-06-04 Xiaoyun Duan; Xiaofeng Liu; Yue Dong; Jing Yang; Jing Zhang; Shujuan He; Fatang Yang; Zhen Wang; Yuming Dong
Sulfonamides have been widely used in the prevention and clinical treatment of bacterial diseases in livestock and poultry. The use of sulfonamides increases the risk of veterinary drug residues in animal derived foods. The traditional reversed phase liquid chromatography methods for sulfonamides residues detection in animal derived foods have the problem of high consumption of organic solvents.
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Phenols, Flavors, and the Mediterranean Diet J. AOAC Int. (IF 1.51) Pub Date : 2020-06-04 Manel Issaoui; Amélia Martins Delgado; Giorgia Caruso; Maria Micali; Marcella Barbera; Hager Atrous; Amira Ouslati; Nadia Chammem
Phenols or phenolics are a class of compounds that have one or more hydroxyl groups attached to a 6-carbon aromatic ring, they occur as plant secondary metabolites, having in common the antioxidant activity. Their average daily intake varies widely around the world. Many researchers consider coffee, tea, wine, cocoa products, fruits and vegetables as the main sources of polyphenols in different diets
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Determination of Chloramphenicol and Nitrofuran Metabolites in Cobia, Croaker, and Shrimp Using Microwave-Assisted Derivatization, Automated SPE, and LC-MS/MS–Results from a U.S. Food and Drug Administration Level Three Inter-Laboratory Study J. AOAC Int. (IF 1.51) Pub Date : 2020-06-04 Brian T Veach; N Bandara; B Broadaway; C Casey; A Fong; A Karmakar; M Mayweather; A Morara; N Williams; B Wright; L Ye
An interlaboratory study was conducted to test a published, peer-reviewed manuscript in the Journal of AOAC INTERNATIONAL Vol 98, No. 3, 2015, “Quantitation of Chloramphenicol and Nitrofuran Metabolites in Aquaculture Products Using Microwave-Assisted Derivatization, Automated Solid-Phase Extraction, and LC-MS/MS.”
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Appendix R: Guidelines for Verifying and Documenting the Relationships Between Microbial Cultures J. AOAC Int. (IF 1.51) Pub Date : 2020-06-04 Zhang D, Vega F, Infante F, et al.
Microbial cultures are dynamic systems that can accumulate inheritable changes when propagated and/or stored in laboratory environments. These changes often affect key virulence traits that are targeted during the development and testing of medical countermeasures and pathogen detection assays. For example, laboratory-propagated Francisella tularensis and Coxiella burnetii tend to lose distinctive
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Sensitive derivative synchronous and micellar enhanced ecofriendly spectrofluorimetric methods for the determination of atenolol, diclofenac and triclosan in drinking tap water J. AOAC Int. (IF 1.51) Pub Date : 2020-07-23 Nardine Safwat; Maha F Abdel-Ghany; Miriam F Ayad
Nowadays, emergence of unexpected contaminants in drinking water is a challenging environmental problem facing humanity.
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