A rapid total fat quantitation method for sunflower oil powder was developed using time domain nuclear magnetic resonance (TD-NMR). Currently, industry has three major methods for the total fat quantitation: gravimetric analysis after ether extraction (AOAC 933.05 and 989.05), gas chromatography with flame ionization detector (GC-FID AOAC 996.06), and high resolution NMR. The gravimetric analysis method

Posaconazole is a triazole antifungal drug approved by FDA in 2006. No bioassay is available in literature or official codes for potency determination in bulk.

Wine color is usually considered to be one of the important indicators to judge the red wine quality, and is also employed to evaluate the wine ageing, while the wine color can be influenced by many factors.

Veterinary drug residues in food are substances (>200 compounds) exhibiting potential health risks for consumers, thus being regulated in national legislations and the Codex Alimentarius. Most of the compounds are regulated based upon a maximum residue limit (MRL) while a few of them are banned in food for humans. The food sector needs a reliable and consensus analytical platform able to monitor these

Well-known medicinal plants Ricinus communis Linn. and Euphorbia hirta Linn. have been traditionally used to treat a variety of ailments in the India and other countries.

Actaea racemosa (Black cohosh) herbal dietary supplements are commonly used to treat menopausal symptoms in women. However, there is a considerable risk of contamination of A. racemosa herbal products in the natural health product (NHP) industry, impacting potential efficacy. Authentication of A. racemosa products is challenging because of the standard, multi-part analytical chemistry methods that

The impact of mathematical manipulation on the efficiency of smart spectrophotometric approaches was considered for analyzing a veterinary binary mixture of tylosin tartrate (TYT) and doxycycline hydrochloride (DOX).

Rufinamide is a triazole derivative that is structurally dissimilar to other marketed antiepileptic drugs, has been assumed a marketing authorization, by the European Union and FDA, for use as a complementary therapy for seizures associated with Lennox-Gastaut syndrome.

Entada phaseoloides (Linn.) Merr. (Family: Fabaceae), is a well-known traditional medicinal plant and has been extensively used in Ayurvedic system of medicine for centuries to combat wide range of ailments.

Two chromatographic methods were described for simultaneous determination of the antihypertensive drugs amlodipine besylate (AML) and bisoprolol fumarate (BIS).

AZD3264 is a small molecule inhibitor of selective IkB-kinase IKK2 currently in preclinical development for the potential treatment of asthma and COPD.

Despite exhibiting wide range of in vitro and in vivo pharmacological activities by many Phyllanthus species, little is known about the compounds present in the extracts that are responsible for those actions.

Abstract BackgroundColor additives requiring batch certification by the U.S. Food and Drug Administration have Code of Federal Regulations (CFR) specification limits for certain elements and are usually analyzed by x-ray fluorescence spectrometry (XRF). However, analysis of some color additives presents difficulties. ObjectiveAn XRF method was developed for quickly determining whether barium sulfate-containing

The Official American Oil Chemists Society (AOCS) Standard Procedure Aa 4-38, AOCS Standard Procedure Am 5-04, ISO 11085:2015 and similar methods are based on extraction of fats from food products using organic solvents. These methods require large volumes of organic solvents and up to 18-hour extractions. The SafTest Percent Fat measures fat content as “total triglycerides” in solubilized snack products

The Ethanol Assay Kit is an enzymatic test kit developed by Megazyme for the determination of ethanol in a variety of samples. The kit has been validated in a single laboratory for use with Kombucha fermented drinks, fruit juices and low-alcohol beer samples. The commercially available Ethanol Assay Kit (Megazyme catalogue no. K-ETOH) contains all components required for the analysis. Quantification

Flavanols and procyanidins are complex bioactives found in many foods like cocoa. As their consumption is associated with health benefits, cocoa flavanols and procyanidins are receiving increasing attention from consumers, industry, researchers, and regulators.

QishenYiqi dripping pills (QSYQ), composed of four herbal medicines including Salvia miltiorrhiza, Astragalus membranaceus, Panax notoginseng and Dalbergiaodorifera, is widely used to treat ischemic cerebrovascular and hemorrhagic cerebrovascular.

According to literature reports, none of the previous methods of analysis had touched the multivariate approach for the quantification of significant factors affecting the interaction of dobutamine or hexoprenaline with Terbium.

Liquid chromatography with tandem mass spectrometry is used widely used for the quantitative analysis of phytoconstituents present in medicinal plants to assess the quality of extract used for different investigations. A sensitive, precise, and accurate liquid chromatographic method with tandem mass spectrometric detection was developed for simultaneous quantification of lupeol, betulinic acid, and

The quantification of faecal Ca-fatty acid soaps is important to understand how fatty acids behave in the gastrointestinal tract.

The RIDA®SMART APP is a smartphone application, which was developed as a quantitative and fast on-site/on-field tool for mycotoxin analyses. Typical operational locations are grain mills, feed mills, ethanol plants, flour producers, but also mobile laboratory services that analyze the grain during harvest in the field. Due to the smartphone-based application there are several advantages. It is a small

The GENE-UP®Listeria spp. 2 (LIS 2) assay (Performance Tested MethodSM 121803) is a real-time PCR molecular detection method for the rapid detection of Listeria species (Listeria monocytogenes, L. innocua, L. ivanovii, L. seeligeri and L. welshimeri) in a variety of foods and environmental surfaces.

Bisphenol A (BPA) is a chemical of concern in food industry. There is need for sensitive analytical method for determination of BPA in beverages.

A method has been developed and validated for selective, accurate and precise determination of total proteinogenic amino acids and taurine from Infant Formula and Adult/Pediatric Nutritional Formulas (powders, ready-to-feed liquids, and liquid concentrates). The method was reviewed by the AOAC INTERNATIONAL SPIFAN Expert Review Panel (ERP) during the 133rd AOAC Annual Meeting & Expo on September 7

Pesticide residues in traditional Chinese medicines pose a potential risk to human health. However, little is known about the characteristics of pesticide residues in the fritillariae thunbergii bulbs (FTB).

The L.p.SG1 DETECT Kit is a rapid, quantitative method for the detection and enumeration of Legionella pneumophila serogroup 1 (L.p. SG1) bacteria from different water matrixes. The method is based on a combination of immunomagnetic separation (IMS) and flow cytometric (FCM) quantification. To this end, the method employs magnetic particles conjugated to anti-L.p. SG1 antibodies for the IMS of the

A naturally occurring material, namely the sporopollenin (SP), was subjected to an easy physical surface modification process called a polydopamine coating. The treatment changed the acid-base properties of the surface, so that in the new form, the SP surface gained a very attractive character for anionic dyes.

Pesticide residues are analyzed in thousands of samples yearly by national authorities and private laboratories. Intensive research is ongoing to develop new methods or improve existing ones concentrating on the extraction, cleanup, and detection techniques. Little attention has been paid to the contribution of prior steps in the determination process to the overall laboratory sampling error, though

Fish fraud is a problematic issue for the industry that to be properly addressed requires the use of accurate, rapid and cost-effective tools. In this work, near infrared reflectance spectroscopy (NIRS) was used to predict nutritional values (protein, lipids and moisture) as well as to discriminate between source (farmed vs. wild fish) and condition (fresh, defrosted or frozen fish). Five whitefish

Many food recalls are related to the presence of undeclared allergens and microorganisms in food products. To reduce these occurrences, portable diagnostic assay kits are available to quantitate mycotoxins, detect allergens and gluten in foods and on environmental surfaces and for sanitation monitoring.

Citrus industry has grown exponentially as a result of increasing demand on its consumption making it stand high among other fruit crops. Therefore, the citrus sector seeks rapid, ease and non-destructive approaches to evaluate in real-time and in situ the external and internal changes in physical and nutritional quality at any stage of fruit development or storage. In particular, vitamin C is among

Chromium is an interest element because its toxicity depends on its speciation. Thus, knowledge of Cr speciation in cow milk is essential to human health.

In 2015, the US Food and Drug Administration passed a ban on the “generally recognized as safe” status of partially hydrogenated oils (PHOs), and in June 2018, PHOs were prohibited from being used. Our objective was to develop a predictive model to quantify trans-fat concentrations in bakery and snacks products using a portable mid-infrared (MIR) spectrometer. The approach was tested using 24 calibration

Rice is an important staple food that is consumed around the world. Like many foods, the price of rice varies considerably, from very inexpensive for low-quality product to premium pricing for highly prized varieties from specific locations. Therefore, like other foods it is vulnerable to economically motivated adulteration through substitution or misrepresentation of inferior quality rice for more

Extracts of milk thistle, Silybum marianum (L.) Gaertn., are used as dietary supplements for their hepatoprotective, anti-inflammatory and anti-tumor activities.

Solanesol is an important pharmaceutical intermediate raw material, mainly used to synthesize coenzyme Q10, vitamin K2. It can be found prominent in potato stems and leaves. But now potato stems and leaves are always abandoned or discarded as they are not suitable for use as feed in aquaculture or other purposes. These agricultural waste resources can be reutilized as the corresponding extracts.

Physicochemical and microbiological methods are found in the literature for the analysis of daptomycin, an antimicrobial.

A new and simple effervescent CO2-table induce switchable hydrophilicity solvent extraction method (CI-SHS) was used for the preconcentration of rhodamine B.

Synthetic antioxidants had toxigenic effects, a growing interest focused on substituting it by natural ones. Attention focused to extract it from the agricultural industries residual to minimize its costs. Legumes seeds hull could be cheap sources of such natural antioxidants.

Although more information has become available on the occurrence of phthalates and di(2-ethylhexyl) adipate (DEHA) in foods including cow’s milk, information on their presence in human milk, the important and recommended sole diet for infants up to six months of age, is very limited, especially for DEHA.

Artemisiae argyi Folium has been used as herbal medicine and food supplement in China and other Asian countries. There is no report about whether the different developmental stages can influence the bioactive compositions of Artemisiae argyi Folium.

Cranberry proanthocyanidins (c-PAC) are oligomeric structures of flavan-3-ol units, which possess A-type interflavan bonds. c-PAC differs from other botanical sources because other PAC mostly have B-type interflavan bonds. Cranberry products used to alleviate and prevent urinary tract infections may suffer from adulteration, where c-PAC are replaced with less expensive botanical sources of PAC that

Kombucha is a fermented beverage made with tea, sugar, and a symbiotic colony of bacteria and yeast (SCOBY) that is usually marketed as a non-alcoholic beverage. Products must contain <0.5% and <1.1% alcohol by volume (ABV) in the United States and Canada respectively to be classified as non-alcoholic products. Prior studies have found that Kombucha beverages can become very acidic and may contain

Comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GC×GC-TOF MS) is the most informative analytical approach for chemical characterization of the complex food volatilome. Key analytical features include: separation power and resolution enhancement; improved sensitivity; and structured separation patterns from chemically correlated analytes.

We describe the use of in silico approaches to improve the process of molecular assay development and reduce time and cost by utilizing available databases of whole genome pathogen sequences combined with modern bioinformatics and physical modeling tools. Well-characterized assays are needed for accurately detecting pathogens in environmental and patient samples and also for evaluation of the efficacy

Reveal® 3-D for Peanut is an immunochromatographic, lateral flow test for qualitative detection of peanut residue in food manufacturing and food preparation settings. The test can detect low ppm levels of peanut in clean-in-place (CIP) rinses and in swabs from environmental surfaces and can serve as a tool in managing allergen risk.

Determination of different drugs in the presence of their impurities is now receiving attention from regulatory authorities such as the ICH and the United States Food and Drug Administration (USFDA).

The U.S. Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) reference culture method uses Modified Letheen Broth (MLB) for microbiological analyses for all types of cosmetic products.

A quantitative NMR (qNMR) method can provide rapid analysis compared to chromatographic methods. Sample preparation steps are relatively simpler and run time is shorter. Rapid analysis methods for release tests in quality control laboratories are very important for laboratory efficiency. Here, we describe a single-laboratory validation study for a rapid qNMR analysis of L-arginine, L-citrulline, and

The interest in polyphenols from vegetable sources has been progressively increased because of the demonstrated correlation between their abundance in certain foods or food preparations of traditional importance and heritage, and the answer of anti-inflammatory strategies in hospitalized patients in the presence of polypehnol-rich foods (as a complementary therapy). Consequently, research involving

To provide guidance on standardization of practices for the collection, characterization, and use of soil as a sample matrix or potentially interfering substance in biothreat agent detection applications.

Aminexil, a new compound patented by L’Oreal, has a stimulating effect on human keratin fibers. Pyridoxine HCl and niacinamide are added to boost the hair tonic effect of aminexil.

Allergies represent an important health problem in industrialized countries. Allergen sensitization is an important risk factor for the development of allergic diseases; thus, the identification of an individual’s allergen sensitization is essential for the diagnosis and treatment of diseases.

A multi-laboratory study was completed for AOAC First Action Method 2015.14. Ten laboratories from eight countries participated. Each laboratory analyzed (in duplicate) a placebo and 14 fortified nutritionals. Product matrices analyzed included milk, soy, partially hydrolyzed milk, partially hydrolyzed soy, and elemental-based infant formula powders, milk based infant formula ready-to-feed liquids

Imidocarb dipropionate (IMD) is an immunomodulator agent commonly used for treatment of anaplasmosis in cattle.

Sulfonamides have been widely used in the prevention and clinical treatment of bacterial diseases in livestock and poultry. The use of sulfonamides increases the risk of veterinary drug residues in animal derived foods. The traditional reversed phase liquid chromatography methods for sulfonamides residues detection in animal derived foods have the problem of high consumption of organic solvents.

Phenols or phenolics are a class of compounds that have one or more hydroxyl groups attached to a 6-carbon aromatic ring, they occur as plant secondary metabolites, having in common the antioxidant activity. Their average daily intake varies widely around the world. Many researchers consider coffee, tea, wine, cocoa products, fruits and vegetables as the main sources of polyphenols in different diets

An interlaboratory study was conducted to test a published, peer-reviewed manuscript in the Journal of AOAC INTERNATIONAL Vol 98, No. 3, 2015, “Quantitation of Chloramphenicol and Nitrofuran Metabolites in Aquaculture Products Using Microwave-Assisted Derivatization, Automated Solid-Phase Extraction, and LC-MS/MS.”

Microbial cultures are dynamic systems that can accumulate inheritable changes when propagated and/or stored in laboratory environments. These changes often affect key virulence traits that are targeted during the development and testing of medical countermeasures and pathogen detection assays. For example, laboratory-propagated Francisella tularensis and Coxiella burnetii tend to lose distinctive

Nowadays, emergence of unexpected contaminants in drinking water is a challenging environmental problem facing humanity.