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Paper-based Microfluidic Devices for the Analysis of Various Pathogens from Diverse Samples Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-03-14 Namita Ashish Singh, Nitish Rai, Ashish Kumar Singh, Vidhi Jain, Jagriti Narang
: In today’s era, detection of disease is utmost important for the management of disease. Early detection leads to early management of disease. Paper-based microfluidic devices are promising technologies that are cost-effective, portable and easy to use over conventional methods. In addition, paper-based microfluidics offers low reagent/sample volume, less response time and can be used in resource-limited
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Advancing Diagnostics: Evaluating the Potential of Nanoparticle-Based Immunoassays as PCR Alternatives for Disease Confirmation Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-03-12 Aditya Kurdekar, Venkataramaniah Kamisetti
: In diagnostic technologies, searching for quick, accurate, and cost-efficient ways to confirm diseases has prompted the investigation of alternative methodologies to classic PCR-based tests. This article delves into the growing field of nanoparticle-based immunoassays, offering a comprehensive evaluation of their potential as viable alternatives to PCR for disease diagnostics. We discuss the basic
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Sorption Efficacy of Weathered Basalt Rock for Metal Ions of Nuclear Importance Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-03-11 Harshala Parab, Rahul Sirvi, Shrutika Kadam, Pranesh Sengupta, Sangita D. Kumar, Uttam K. Bhui
Background:: A safe and long-term isolation of radionuclides is crucial for efficient waste management in the nuclear fuel cycle. Clay minerals of geological origin are considered candidate barrier materials for the sequestration of nuclear waste for geological disposal applications. Objective:: The present study encompasses a systematic characterization of weathered basalt rock and the influence of
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A Study on the Anti-inflammatory Activity of Clematis tangutica Using Molecular Networking Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-03-08 Aijing Li, Tao Chen, Shuo Wang, Juyuan Luo, Cheng Shen, Hongmei Li, Yumei Ma, Zhibo Song, Weihang Lu, Denglang Zou, Yulin Li
Background:: Clematis tangutica, an indigenous medicinal herb native to the Qinghai- Tibet Plateau of China, has traditionally been associated with treating various inflammation-related diseases. While its therapeutic potential is recognized, a comprehensive characterization of its metabolite molecules and their anti-inflammatory properties has not been undertaken. Objective:: This study aimed to comprehensively
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Citrus Essential Oils as Potential Insecticides Against Thrips flavus Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-03-01 Tian-hao Pei, Yu-Long Niu, Bin Liu, Ming Yuan, Ai-Guo Zhang, Xiao-Feng Li, Lian-Xia Wang, Meng-Lei Xu, Yu Gao
Background: Essential oils (EOs) are recognized for their potent insecticidal activity and are widely considered promising agents for pest control. Methods: The insecticidal activity of seven commercial citrus EOs against the global phytophagous pest Thrips flavus was evaluated using bioassays conducted under laboratory conditions. Moreover, the chemical composition of these EOs was analyzed using
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Effects of Salvianolate Injection on the Pharmacodynamics and Pharmacokinetics of Warfarin in Rats in vivo Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-03-01 Yue Zhao, Jiahui Sun, Shiwei Xu, Yan Liu, Mengnan Qin, Chunjuan Yang, Gaofeng Liu
Background:: Both Salvianolate Injection and warfarin are widely prescribed in patients with cardiovascular diseases, but the interaction between them is unknown and needs to be investigated. Objective:: This research aims to study the effects and mechanism of Salvianolate Injection on the pharmacodynamics and pharmacokinetics of warfarin in rats. Methods:: Male Wistar rats were intraperitoneally injected
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Influence of the Presence of Sulfur and Oxygen Atoms on Molecular, Thermodynamic and Transport Properties in Hydrocarbon Mixtures Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-03-01 Josue F. Perez-Sanchez, Ruth del C. Galindo-Lopez, Edgardo J. Suarez Dominguez, J. Rafael Rodriguez- Rodriguez, Yoana Perez-Badell, Elena F. Izquierdo Kulich
Introduction: Crude oil is a complex blend of various hydrocarbon families, with compositions that vary depending on the source well and exploitation duration. To categorize its constituents, SARA analysis divides them into saturated, aromatic, resins, and asphaltenes. Heavy asphaltene- rich crude oils can present challenges like viscosity and pipeline blockages, which are often addressed with viscosity-reducing
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Magnetite Reduced Graphene Oxide/Ordered Mesoporous Carbon Nanocomposite as Effective Adsorbent for Removal of 2-Naphthol in Wastewater Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-02-27 Fatemeh Chaltash, Fereshteh Chekin, Seyed Mohammad Vahdat
Background: The wastewater released from various industries contains substantial amounts of organic compounds such as dyes and naphthols. However, naphthols are toxic to the environment and human health. So, it is essential to eliminate them, which will contribute to manufacturing and environmental management. Methods: In the work, an eco-friendly method is adapted to synthesize reduced graphene oxide
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Extraction Optimization, Structure Analysis and Antioxidant Activity of Polysaccharide from Sanghuangporus baumii Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-02-26 Yunhe Qu, Pingping Zhang, Jing Cui, Xiuzhen Ni, Kai Song, Dongfang Shi
Introduction: In this study, we optimized the extraction process, analyzed the structure and assessed the antioxidant activity of Sanghuangporus baumii polysaccharide (SBP). The present results provide important information for the Sanghuangporus baumii polysaccharides in potential natural antioxidant effects. Background: The extraction and structural analysis of polysaccharides from Sanghuangporus
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A Review of Minimally and Non-invasive Glucose Monitoring Techniques, Devices and Sensors Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-02-15 Mohammad Nooshnab, Seyed Morteza Naghib, Rouhollah Rahmanifard, Elnaz Khakpour
Glucose determination, without pain and aches, is essential for biomedical applications. Minimally invasive (MI) and non-invasive (NI) are the approaches that could address these challenges. MI approaches are based on body fluids such as saliva, urine, tears, and interstitial fluid that are exploited to determine glucose levels. NI methods utilize radiation forms to determine glucose concentration
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HPLC-MS/MS Method for the Quantitative Determination of Metformin in Rat Plasma and Its Application to Comparative Bioavailability Assessment Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-02-15 Di-Di Zhang, Young-Heun Jung, Mi-Ji Seol, Siyu Zhou, Dinesh Chaudhary, Jee-Heon Jeong, Ju-Hyun Kim
Background: Metformin is a biguanide derivative utilized as a first-line treatment for type 2 diabetes for people over 60 years. However, it faces certain limitations due to its incomplete absorption, resulting in a 50-60% bioavailability. In addition to its blood glucose-lowering effect, the antiproliferative effect of metformin has been demonstrated in vitro. Therefore, it is necessary to consider
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Design and Fabrication of Silver Nanoparticles Doped β-cyclodextrin-chitosan Functionalized Graphene Nanocomposite Modified Electrode for Determination of Cu(II) Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-02-13 Abdullah Akhdhar, Mona Saad Binkadem, Waleed Ahmed El-Said, Amr A. Yakout
Introduction: In this study, a nanocomposite film was prepared by doping silver nanoparticles onto β-cyclodextrin-chitosan functionalized Reduced Graphene Oxide (RGO), denoted as Ag/ β-CD/CS/G nanocomposite. The average diameter of the Ag NPs was found to be 62±17 nm. Method: The fabricated composite was applied to monitor trace levels of copper ions in different industrial and environmental water
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Development of an Indirect ELISA for the Detection of Lactoferrin in Type 2 Diabetes Plasma: A Novel Approach Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-02-09 Amani Alhalwani
Background: In biological systems, lactoferrin (LF) is a crucial protein for protecting the body against diseases and pathogens that can affect both humans and animals. LF is a multifunction protein that binds to different surface receptors to stimulate the innate immune system. In diabetes, lactoferrin has a direct association with inflammation. The effects of inflammation interaction are unknown
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Research Progress in the Detection of Aflatoxin B1 Based on Aptamers Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-02-07 Yi Zhang, Xiaofang Chen, Xiaoyi Xie, Dong Li, Yuxiu Fan, Bin Huang, Xiupei Yang
Aflatoxin B1 is highly toxic, mutagenic, teratogenic, and carcinogenic and is a class I carcinogen. Peanuts, cotton, and corn may be affected by AFB1 during cultivation, which can seriously jeopardize human health. Developing a simple, sensitive, and selective method for detecting AFB1 is imminent. Aptamers are obtained through in vitro screening of ligands by single-stranded oligonucleotides (DNA
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Quantitative Applications of ATR-FTIR Spectroscopy with Chemometrics for the Estimation of Amikacin in Amikacin Sulphate Injections Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-02-06 Chow Jie Chen, Bontha Venkata Subrahmanya Lokesh, Gabriel Akyirem Akowuah
Background: Amikacin belongs to the class of aminoglycoside antibiotics used in the treatment of gram-negative bacterial infections. It is resistant to the aminoglycosides modifying enzymes, making it a clinically effective drug in multidrug-resistant infections. Methods: In this study, a simple Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy was used for the quantification of
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Ultrasound-assisted Aqueous Two-Phase Extraction of Flavonoids from Scutellariae Radix and Evaluation of their Bioactivities In Vitro Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-30 Zhenkai Ge, Yongheng Zhao, Xu Ling, Chenpan Zhu, Xincai Hao
Background: Scutellariae Radix, one of the most widely used herbs in Traditional Chinese Medicine, exhibits various biological activities due to its chemical components, which stand out for a number of flavonoids. In this study, Ultrasound-assisted aqueous two-phase extraction (UAATPE) was employed for the first time to obtain a high extraction rate and high purity of flavonoids from Scutellariae Radix
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Rapid Determination of Diverse Ganoderic Acids in Ganoderma Using UPLC–MS/MS Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-30 Yan Yang, Yuying Jian, Bin Liu
Background: Ganoderma is known for its pharmaceutical, nutritional, and functional benefits. Its primary bioactive components are ganoderic acids. However, previous quantification methods only analyzed an individual or limited number of ganoderic acids. This study aims to develop a reliable method for simultaneously quantifying the major ganoderic acids to enhance Ganoderma quality control and study
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Heavy Metals in Blood Serum of Smokers and Non-smoking Controls Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-29 Abdulhussein Abdulameer Alkufi, Mohanad Hussain Oleiwi, Ali Abid Abojassim
Background: The analysis of heavy metals in the blood serum can serve as a reliable indicator for establishing the association between cigarette smoking and the presence of heavy metals. Methods: In this study, performed in Al-Najaf during 2023, concentrations of three heavy metals - cadmium (Cd), chromium (Cr), and lead (Pb) – were investigated in two groups: cigarette smokers, and non-smokers (the
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Construction of a Miniaturized Electrochemical Sensor for Voltammetric Detection of 17β-Estradiol Using a g-C3N4-Decorated Gold Nanoparticles Electrode Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-29 Yue Ma, Xuqiao Liu, Kai Yan, Jingdong Zhang
Background: 17β-estradiol (E2) is a steroid hormone that has the potential to disrupt the endocrine system, leading to adverse effects on both humans and ecosystems, even when present in low concentrations. The quantitative determination of E2 is of great practical significance. Hypothesis: Electrochemical methods offer several advantages, including low cost, ease of operation, and potential for miniaturization
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Study on the Chemical Composition of the Mainstream Cherry-red Tobacco Smoke Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-29 Yong Li, Tao Pang, Yihan Zhang, Junli Shi, Zhongbang Song, Zhaoli Xu
Introduction: Cherry-red tobacco is a flue-cured variant that possesses a distinctive “sticky rice” flavor, which is highly valued by the tobacco industry. However, the value of cherryred tobacco is dubious due to the possible health risks associated with tobacco-specific nitrosamines (TSNAs). Objective: This study aimed to investigate the chemical origin of the “sticky rice” flavor and to assess the
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Quantification of Rutin, an Anti-glycating Drug, in Selected Euphorbia Species by Florescence Spectroscopy and Partial Least Squares Regression Analysis Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-28 Maroof Ali, Ajmal Khan, Syed Abdullah Gilani, Liaqat Ali, Rabia Maqsood, Amjad Hussain, Hamida Al Rabani, Najeeb Ur Rehman, Farah Jabeen, Fazal Mabood, Ahmed Al-Harrasi, Javid Hussain
Background: Rutin is a natural flavonol that showed excellent antiglycation activity with an IC50 value of 294.5 ± 1.5 μM. In the current study, three selected plant species of Euphorbia, i.e., Euphorbia helioscopia, Euphorbia larica, and Euphorbia wallichii, were analyzed for the quantification of rutin. Methods: The quantification was done through a newly developed method of Emission spectroscopy
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Green Synthesis Derived Novel Fe2O3/ZnO Nanocomposite for Efficient Photocatalytic Degradation of Methyl Orange Dye Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-23 Nimisha Jadon, Bhupinder Kour, Bilal Ahmad Bhat, Harendra K. Sharma
Introduction: An eco-friendly method was reported for the synthesis of ferric oxide nanoparticles (Fe2O3), zinc oxide nanoparticles (ZnO) and Fe2O3/ZnO nanocomposite using Mangifera indica plant leaf extract as a natural reducing agent. Methods: The synthesized nanomaterials were successfully characterized by X-ray diffraction, UVvisible spectrophotometer, Photoluminescence spectroscopy and Transmission
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Review on Phytoremediation: Toxic Heavy Metal Removal Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-22 Rajesh Nithyanandam, Moontarij Jahan Orvy, Rajavarsini Rajesh, Rupika Rajendran, Jyotsna SudhiMithran
Among the environmental contaminants in water, heavy metals and other pollutants are becoming a common occurrence. To solve this issue, the process of phytoremediation was utilized to clear up polluted media. Heavy metal and other pollution contamination of water is becoming more common, which has prompted a conversation that goes beyond heavy metals. These
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A Systematic Study of Pyracantha crenulata Phytoconstituents for their Anti-Diabetic Activity Using Computational Techniques Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-11 Girish Chandra Arya
Background: Diabetes mellitus is a significant medical condition with rising incidence and fatality rates. According to WHO, around 422 million individuals globally have diabetes, the majority of whom live in low and middle-income economies. Diabetes is entirely responsible for 1.5 million fatalities yearly. Researchers are concentrating on plant derivatives due to the higher toxicity of conventional
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Identification and Limit of Detection of Benzene, Chlorobenzene, Benzoic Acid, Phthalic Acid, and Mellitic Acid in Water Solutions Using Excitation, Emission, and Single-band Synchronous Fluorescence Spectroscopy Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-09 Suresh Sunuwar, Carlos E. Manzanares
Introduction: This paper first introduces the use of computer-simulated single-band synchronous fluorescence (SF) obtained from experimental excitation and emission fluorescence spectra of a pure compound in solution. The simulation produces a single narrow band with a peak wavelength that identifies the compound. Method: The method is used to show single peak identification of benzene, chlorobenzene
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Mechanical Activation as a Stage of Coal Sample Preparation in the Analysis of Rare Earth Elements Content by Inductively Coupled Plasma Mass Spectrometry Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-09 Lidiya I. Yudina, Tatiana S. Skripkina, Svetlana S. Shatskaya
Background: Brown coals are recognized as promising sources of rare earth elements (REEs). Rare earths are present in both the mineral and organic parts of brown coal. Objectives: This study was conducted to investigate the influence of preliminary mechanical activation in the process of sample preparation prior to analyzing the concentrations of rare earth elements in brown coal samples of various
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Metal-organic Frameworks: Emerging Luminescent Sensors Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-09 Meman Sahu, Vanshika Sharma, Goutam Kumar Patra
Metal-organic frameworks (MOFs), a crystalline material, are a new type of inorganicorganic hybrid material. MOFs are of great interest to researchers in chemistry and material science due to their various chemical and physical properties, and features include their remarkable surface area, high porosity, flexibility, structural variety, flexibility, extreme porosity, a large surface area, augmented
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HPLC Analysis of Vitamins C, E, Beta-carotene, and Some Flavonoids in Armenian Red Wines Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-09 Ani A. Grigoryan, Ani A. Hayrapetyan, Zhermen A. Azaryan, Siranush V. Harutyunyan, Aleksandr P. Yengoyan
Background: Oxidative damage to biological molecules is mainly caused by free radicals produced in the body. Natural antioxidants can prevent the resulting oxidative stress. For this purpose, particularly grapes and grape products, which contain vitamins and polyphenolic substances with high antioxidant activity, are used. Methods: In the present study, the content of vitamins C and E, beta-carotene
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Label-free Electrochemical Nanobiosensors Using Au-SPE for COVID-19 Detection: A Comparative Review of Different Biomarkers and Recognition Elements Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-09 Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib
An immediate and precise diagnosis is required due to the COVID-19 outbreak. Labelfree electrochemical biosensors show promise as potentially valuable instruments for detecting COVID-19. These biosensors are distinguished by their lack of complexity, high speed, sensitivity, and relatively low cost. The precise COVID-19 biomarkers may be recognized without labeling or amplification by detecting the
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Method Development and Validation for Simultaneous Detection of Corticosteroids, Small Peptides, SARMs and Quaternary Ammonium Drugs in Camel Urine for Doping Control Applications Curr. Anal. Chem. (IF 1.8) Pub Date : 2024-01-05 Jahfar Nalakath, Rasik P.T., Praseen O.K., Shamil P., N. Selvapalam, E.R. Nagarajan
Background: Detection and identification of a wide range of drugs, including small peptides, corticosteroids, selective androgen receptor modulators (SARMs), and quaternary ammonium drugs (QADs), are imperative across several domains, particularly in anti-doping analysis, given the potential misuse of these substances in animal sports, there is an urgent demand for an allencompassing screening method
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New Green and High-throughput Microwell Spectrophotometric Method for Quality Control of Pharmaceutical Formulations of Selective Serotonin Reuptake Inhibitors via Microscale Formation of their N-Vinylamino-naphthoquinone Derivatives Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-12-28 Reem M. Abuhejail, Nourah Z. Alzoman, Ibrahim A. Darwish
Background: Selective serotonin reuptake inhibitors (SSRIs) are mostly prescribed for the treatment of depression. This study describes the microscale in-microwell formation of blue-colored N-vinylamino-naphthoquinone derivatives of SSRIs upon their reaction with 2,3-dichloro-1,4- naphthoquinone (DCNQ) and acetaldehyde. The reaction was subsequently utilized as a basis for the development of a new
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Colorimetric and Electrochemical Sensors for the Detection of Sarcosine, A Potential Biomarker for Prostate Cancer: A Review Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-12-12 Vaishnavi Venugopal Iyer, Rajapriya Rajendran, Stalin Selvaraj
Sarcosine is currently identified as a potential biomarker for prostate cancer. It is n-methyl derivative of glycine, which is naturally present in muscle and body tissues. Studies indicate that a delay in the treatment of prostate cancer is often due to its diagnosis not being possible at earlier stages. Also, plasma and urine samples with increased sarcosine concentration exhibit a higher probability
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A Bioinformatics Study of the Influenza H5N1 Virus that Infects Wild Fowl and Poultry and, Potentially, Humans Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-12-08 Carlos Polanco, Vladimir N. Uversky, Alberto Huberman, Enrique Hernandez-Lemus, Mireya Martínez-Garcia, Claudia Pimentel Hernández, Martha Rios Castro, Thomas Buhse, Gilberto Vargas Alarcon, Jorge Alberto Castañón González, Juan Luciano Díaz González, Mauricio Missael Sanchez Díaz, Erika Jeannette López Oliva, Francisco J. Roldan Gomez, Brayans Becerra Lun
Introduction: More than sixteen countries are infected with the highly pathogenic avian influenza A-H5N1 virus. As the virus circles the world, it has led to the slaughter of millions of poultry birds as well as the infection of farmed mink in Europe and among seals and grizzly bears on the Northern coast of America; some infected mammals exhibited neurological symptoms like disorientation and blindness
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Quantitative HPLC-based Metabolomics Approach for the Discrimination of Processed Rhizomes of Atractylodes Macrocephala Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-12-06 Cao Thanh Hai, Nguyen Thu Uyen, Do Hoang Giang, Nguyen Thi Thu Minh, Hoang Thuy Duong, Bui Thi Nhat Le, Nguyen Trung Thanh, Truong Ngoc Minh, Nguyen Tien Dat
Background: The current study presents a method for the simultaneous quantification of atractylenolide I, II, and III, together with syringin, syringaresinol-4-O-β-D-glucoside and caffeine in Atractylode macrocephala (AM) rhizomes. Contents of the metabolites, in combination with the metabolomics approach, were used to discriminate AM rhizomes, which were processed by different methods. Method: An
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Aluminum Oxide Nanoparticles from Aluminum Door and Window Factory Wastes for the Removal of Methyl Green Dye from Wastewater: A Comparative Study Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-12-06 Wrea Mohammed Ibrahim, Ibrahim Qadr Saeed, Hunar Yasin Muhammad, Hijran Sanaan Jabbar
Background: It has become increasingly important to use non-toxic nanomaterials for treating industrial wastewater that contains organic dyes, such as methyl green. Method: A sol-gel method was used to synthesize aluminum oxide nanoparticles from waste aluminum and investigate the physicochemical process involved in their removal from methyl green. Result: The synthesized adsorbent was characterized
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Fabrication of a Molecularly Imprinted Polymer Adsorbent for Pipette Tip Micro Solid-phase Extraction of Levofloxacin from Aqueous Samples Prior to its Spectrophotometric Determination Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-12-01 Sayyed Hossein Hashemi, Massoud Kaykhaii, Ahmad Jamali Keikha, Jasem Jangizahi
Aims: The main goal of this research was to find a simple, selective, sensitive and rapid protocol for the detection of traces of levofloxacin (Lev) in seawater, pills, urine, and human plasma samples by using a novel sorbent made of molecularly imprinted polymer (MIP) for its pipette-tip micro-solid phase extraction (PT-μSPE), followed by spectrophotometry. Parameters affecting the method were evaluated
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Dengue Fever Virus Envelope Glycoproteins Variability Characterized Bioinformatically Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-11-29 Carlos Polanco, Vladimir N. Uversky, Alberto Huberman, Enrique Hernandez-Lemus, Martha Rios Castro, Erika Jeannette López Oliva, Mireya Martínez-Garcia, Thomas Buhse, Francisco J. Roldan Gomez, Gilberto Vargas-Alarcon, Cecilia Zazueta, Claudia Pimentel-Hernández
Background: The infection caused by the dengue fever virus is a severe threat to public health on a global scale; nevertheless, there is currently no effective medical treatment or vaccine available to prevent or treat the condition. Objective: To better understand the physicochemical regularities of these proteins, it is necessary to carry out a computational multiparametric study of the amino acid
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Molecularly Imprinted Electrochemical Sensor Based on Reduced Graphene Oxide-Gold Nanoparticles-Poly(p-aminobenzoic Acid) Nanocomposites for the Determination of Sunset Yellow Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-11-10 Youyuan Peng, Zhuojialu Li
Background: In this work, the reduced graphene oxide decorated with gold nanoparticles (Au/rGO) had been synthesized on glass carbon electrode (GCE) using a simple one-step electrochemical method. The molecularly imprinted poly(p-aminobenzoic acid) (PABA) film was prepared for the analysis of sunset yellow (SY) on Au/rGO/GCE by electropolymerization of p-aminobenzoic acid (pABA) and SY. Methods: Methods
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Label-free and Colorimetric Sensitive Detection of SNPs Based on Catalytic Beacon and RNase Cleavage Reaction Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-11-07 Zhaojiang Yu, Chunxue Zhao
Background: Single nucleotide polymorphisms (SNPs) are important hallmarks in various pathological activities, especially genetic and inherited diseases, and detecting them with accuracy, high throughput and low cost becomes increasingly necessary. Methods: Methods: Herein, we have developed a new label-free and sensitive detection method for SNPs assay. Due to its favorable traits, the method presents
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Nanotechnology-based Assays for the Detection of Cancer through Sputum Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-11-07 Dilpreet Singh
Cancer remains a formidable global health challenge, underscoring the critical need for early and accurate diagnostic tools. In recent years, nanotechnology has emerged as a promising frontier in cancer detection, offering innovative approaches to enhance sensitivity, specificity, and convenience in diagnostics. This comprehensive review delves into the intersection of nanotechnology and sputum-based
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Study on Separation Mechanism of Ephedrine and Pseudoephedrine in Borax Buffer by Capillary Electrophoresis Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-11-07 Jinqiu Xu, Yinhua Gong, Rongrong Huang, Liangliang Cai, Xiaofei Ma
Background: In borax buffer, ephedrine (EPH) and pseudoephedrine (PSE) can be well separated (Rs>10) in capillary electrophoresis (CE) without adding any other compounds, but the specific mechanism remains unclear. Methods: Titration analysis, nuclear magnetic resonance analysis, mass spectrum analysis and molecular modeling were used to investigate the separation mechanism. Results: Tetrahydroxy borate
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An Improved Amperometric D-amino Acid Biosensor Based on Immobilization of D-Amino Acid Oxidase on Nanocomposite of Chitosan/Fe3O4NPs/ cMWCNT/GC Electrode Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-11-03 Chandra Shekhar Pundir, Suman Lata, Bhawna Batra, Jyoti Ahlawat
Objective: An improved amperometric D aminoacid (DAA) biosensor was fabricated by immobilizing covalently, D-amino acid oxidase (DAAO) onto nanocomposite of chitosan (CHIT)/ iron oxide nanoparticles (Fe3O4)/ carboxylated multiwalled carbon nanotubes (cMWCNT)/ electrodeposited onto glassy carbon (GC) electrode. Methods: The iron oxide nanoparticles (Fe3O4) were prepared and characterized by UV spectroscopy
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A Novel Fluorescent Aptasensor Based on Mesoporous Silica Nanoparticles for Selective and Sensitive Detection of Saxitoxin in Shellfish Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-31 Najeeb Ullah, Beenish Noureen, Qurat ul ain Zahra, Tariq Aziz, Somia Shehzadi, Mohammad Y. Alfaifif, Serag Eldin I. Elbehairif, Khalid Hussain Thebo, Asmat Ullah, Haroon Iqbal
Background: Saxitoxin (STX) stands as one of the most potent marine biotoxins, exhibiting high lethality. Despite its severity, current treatments remain ineffective, and existing detection techniques are limited due to ethical concerns and technical constraints. Methods: Herein, an innovative approach was constructed for STX detection, utilizing mesoporous silica nanoparticles (MSN) as a foundation
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Characterization of a High-performance PCF-SPR Sensor for Biomedical Applications Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-27 Himansu Shekhar Pradhan
Background: Surface plasmon resonance (SPR) based fibre optic sensors are becoming increasingly popular in biomedical applications. However, the sensor performance is degraded because of low sensitivity with inadequate detection accuracy and figure of merit. Objectives: The first objective of this study is to design a D-shaped photonic crystal fibre (PCF) using COMSOL multiphysics. The second objective
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One-step Nonenzymatic Electrochemical Sensor for the Detection of Sarcosine Using Nanozyme Glutathione Copper Complex Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-27 Janani Udayakumar, Stalin Selvaraj
Background: The present study aims to develop the use of glutathione copper complex for the detection of sarcosine, a marker for prostate cancer. The glutathione-copper complex was successfully synthesized at room temperature and characterized using FTIR, UV, and Scanning Electron Micrograph. Methods: The structure of the glutathione copper complex was found to be a 1:2 Metal: Ligand ratio. The cyclic
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Enhancing the Bioavailability of Silymarin Phytopharmaceutical by using Piperine and Fulvic Acid and Simultaneously Quantifying Three Biomarkers in Plasma Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-25 Tanya Ralli, Zoya Saifi, Zakiya Usmani, Vidhu Aeri, Mohd. Aqil, Kanchan Kohli
Background: Silymarin (SM) is a mixture of seven flavonolignans (FL) and one flavonoid extracted from the seeds of the milk thistle plant. The major FLs include silibinin, silychristin, silydianin, and isosilibinin. Silibinin, a mixture of two diastereomers, i.e., silybin A and silybin B, has been found to be the most active biomarker molecule in the extract of SM. Some studies have also demonstrated
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Origin Identification of Astragalus membranaceus Based on Electrochemical Oscillating Fingerprint Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-24 Zufei Feng, Qian Yang, Haixiu Wang, Yangfan Hu, Hua Fan, Yiming Zou, Yingjuan Zhao, Yinglin Yan, Rong Yang, Na Wu
Background: Astragalus, as a common traditional Chinese medicine (TCM), has many pharmacological effects, such as protection of nerves, heart, blood vessels, kidneys, etc. It can also be used to treat colds, numbness, diarrhea, indigestion, and anemia. Because of the current market, there are a large number of synonyms, synonyms, and multiple sources of one medicine. The use of near-edge plants in
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Application of the Static Headspace Method as a Tool for Rapid Control of Fennel Seed Tea Vapors Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-24 Karim Assami, Dalila Meziane-Assami, Zahia Ghouila, Riad Guerroudj, Lazhar Gacem
Background: In recent years, there have been tensions surrounding the accessibility of drugs at pharmacies. This situation has led people to turn to alternative medicine with increased use of plants as medicines. Nevertheless, a good knowledge of the plant's chemical composition is necessary for its proper use due to the presence of toxic products. Objective: The research objectives are to expand a
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Common Causes of False Positive and False Negative Results in Amphetamine Screening Tests Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-24 Stanila Stoeva
The need for toxicological screening of amphetamine users is growing in parallel with its increasing abuse. At the same time, it turns out that these substances most often give false results in rapid drug immunoassay. Therefore, the aim of the present work was to investigate the sources of false positive or false negative results. For this purpose, an analysis of the literature sources in the databases
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A Concise Review on Analytical Methods for Determination of Nilotinib Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-23 Ritika Khivansara, Sandhya Jadhav, Maheshkumar Borkar, Atul Sherje
Nilotinib hydrochloride is a tyrosine kinase inhibitor licensed to treat chronic myelogenous leukemia in patients with the Philadelphia Chromosome (Ph+). Researchers at Novartis Pharmaceuticals discovered novel inhibitors that are effective against imatinib-resistant BCR-ABL mutations. As a consequence, Nilotinib was discovered. Several analytical approaches were employed to address the quantitative
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Fluorescent Materials for Latent Fingerprint Detection Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-12 Puthiyavalappil Rasin, Vaishnu Suresh Kumar, Kailas Mahipal Malappuram, Anandaram Sreekanth
This review provides a comprehensive examination of the application of fluorescence materials for the detection of latent fingerprints in forensic sciences. Traditional methods like powder dusting, cyanoacrylate fuming, chemical methods, and small particle reagent techniques have shown limitations due to issues like low contrast, sensitivity, selectivity, and high toxicity. To overcome these drawbacks
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New Toxicological Endpoints of Pesticides: Perspectives on Metabolomics Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-10 Bizhang Dong
Food safety has received increasing attention, and pesticide contamination is one of the primary issues. Many toxicological endpoints have been established to evaluate the hazards of pesticides. However, the sensitivity of toxic endpoints is dominated by analytical methods. The risks of pesticides may be underestimated when using insensitive analytical methods to establish the toxicological endpoints
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Marine Actinobacterial Streptomyces Sp., Mediated Synthesis of Silver Nanoparticles: Characterization and Different Biological Properties Under In-vitro Condition Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-05 Kannan Kamala, G.J. Jeevan Kumar, Dhanraj Ganapathy, Ashok K. Sundramoorthy, Pitchiah Sivaperumal
Background: Green synthesis of nanomaterials is promising as a biological source for treating different diseases without side effects. Methods: In the present study, marine Streptomyces sp. was used to biosynthesize silver nanoparticles, which were then characterized and evaluated for various therapeutic activities and A 549 breast cancer cell line for cytotoxic evaluation. Results: The Surface Plasmon
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Investigation on the Microbiological Quality and Fatty Acid Methyl Esters Composition of Commercially Available Cold-pressed Nigella sativa L. Oil Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-10-04 Sibel Özçakmak, Manaf AlMatar, Işil. Var, Ali Tekin
Background: Nigella sativa is a traditional plant with several ethno-medicinal activities. There have been several health advantages associated with Nigella sativa (Ns) L. oil, which has a high concentration of bioactive compounds. Method: This research aimed to examine the fatty acid methyl ester profiles, microbiological profiles, and aflatoxin profiles of cold-pressed Ns oils acquired from Turkish
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Determination of Sufentanil in Human Plasma Using Ultra-high Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry (UPLC–MS/MS) Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-09-04 Sang-Min Lee, Suin Kim, Dongseong Shin, Kwang-Hee Shin
Background: Sufentanil, an opioid analgesic, is used as an induction agent for general anesthesia during surgery. Sufentanil is more active than other anesthetics and has a narrow therapeutic range. Therefore, a precise dosage regimen is necessary when administering sufentanil. Objective: This study aimed to develop a bioanalytical method for the determination of sufentanil within the sensitive concentration
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Development of a New, Fully Validated LC-MS/MS Method for the Analysis of Flibanserin in Pharmaceutical Preparations and Comparison of the Chromatographic Performance with Six Stationary Phase Types Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-09-04 Aysun Geven, Saniye Özcan, Serkan Levent, Nafiz Öncü Can
Background: Initially synthesized as an antidepressant and potentially rapid onset of action, flibanserin (FLB) was approved by the Food and Drug Administration (FDA) in August 2015 with a warning to dispense the drug through a dedicated risk management program, despite the removal of HSDD from the DSM-5TM. The drug is the first noteworthy FDA-approved drug for treating premenopausal women with acquired
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Interfacing Silver Nanoparticles with Hematene Nanosheets for the Electrochemical Sensing of Hydrogen Peroxide Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-08-28 Kavitha Rani Thirumoorthi, Kiran Kumar Tadi
Background: Hydrogen peroxide (H2O2) is an important metabolite that plays a crucial role in enzymatic reactions in living organisms. However, it acts as a reactive oxygen species (ROS) that causes various chronic diseases. The main challenging aspects in detecting H2O2 in body cells are the ultra-lowlevel concentrations and its reactivity. Hence, it is highly essential to develop a platform for H2O2
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Development and Validation of HPLC-UV Method for the Determination of Levothyroxine in Orodispersible Minitablets for Pediatric Application Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-08-23 Olivera Camila Belen, Henestrosa Cecilia, Favier Silvina, Dobrecky Cecilia, Flor Sabrina, Lucangioli Silvia
Background: Thyroid hormones play an important role in cognition and brain development. The determination of the content of levothyroxine, as well as related substances and dissolution test analysis, should be carried out by methods that are selective and highly sensitive due to the low concentration used in low dose orodispersible minitablets. Objectives: This study aims to develop and validate an
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Degradation of LDPE Using the Winogradsky Column Containing Otteri Dumpsite Soil: Prediction of Mechanism and Metabolites Determination Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-07-31 Rajalakshmi Sridharan, Vajiravelu Sivamurugan, P. Senthil Kumar, Veena Gayathri K., Gayathri Rangasamy
Background of the Research: Plastic pollution has taken over the world. Toxicity of the plastics and other pollutants is enhanced due to the formation of microplastics and nano-plastics that attract Persistent Organic Pollutants (POPs). The need for the treatment of plastic waste in the current scenario led to the rise of various treatment processes. Biodegradation, an eco-friendly approach to eliminate
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A Case Study on Bacteriological and Physiochemical Evaluation of Hospitals Drinking Water in Pakistan Curr. Anal. Chem. (IF 1.8) Pub Date : 2023-07-24 Muhammad Bilal, Salma Khan, Muhammad Iqbal Khan, Javed Ali, Abdul Wahab, Muhammad Ismail, Kalsoom Akhtar, Esraa M. Bakhsh, Sher Bahadar Khan
Background: Seventy percent of the Earth is covered by water, out of which only 1% is fresh water. This fresh water can be used for drinking and other domestic uses. However, a drastic increase in the industrial revolution resulted in depletion of the reservoirs and contamination of the potable fresh water. Around 3.4 M deaths per annum occur as a result of waterborne diseases. Objectives: Therefore