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Microemulsion liquid chromatographic method for simultaneous separation and determination of five isoflavones in red clover J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2021-01-15 Tianjiao Duan; Haixia Ma; Yuming Dong; Fatang Yang; Xiaofeng Liu
Abstract Green and efficient separation methods are gradually being loved, and microemulsion phase chromatography is used in many fields. This study used a microemulsion liquid chromatographic method for the simultaneous separation of five isoflavones (formononetin, ononin, calycosin, calycosin-7-glucoside, and biochanin A) in red clover within 10 minutes for the first time. Separation and analysis
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Scanning densitometry and mass spectrometry for HPTLC analysis of lipids: The last 10 years J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2021-01-11 Vicente L. Cebolla; Carmen Jarne; Jesús Vela; Rosa Garriga; Luis Membrado; Javier Galbán
Abstract This work is a review on HPTLC contribution to lipid analysis in complex matrices, in the period from 2010 to now, lapse of time where hyphenation with other techniques, especially Mass Spectrometry, has experienced an important growth. Scanning densitometry (SD)-UV/FL of separated lipids, as the core of detection and centerpiece for hyphenation, and its coupling with MS using soft ionization
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Analytical determinations of haloperidol and its combinations in pharmaceutical dosage forms and biological matrices J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2021-01-08 R. Santhosh Kumar; C. N. Nalini
Abstract Haloperidol is a highly potent, first-generation antipsychotic drug used for the treatment of several disorders. It exerts its antipsychotic effect through the strong antagonism in the dopamine D2 receptor. Effective analytical procedures are required for clinical and pharmaceutical studies. In this review, a variety of analytical techniques and associated methodologies for the determination
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HPTLC fingerprinting, photopigments, and nutrient analysis of Selinum tenuifolium along the altitudinal gradient J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2021-01-06 Ravi Prakash Srivastava; Pooja Dixit; Lav Singh; Nem Kumar Nagpoore; Shivaraman Pandey; Praveen C. Verma; Vivek Rawat; Gauri Saxena
Abstract This study aimed to explore phenolic acids, nutrient status, and content of photopigments and their role in the production of secondary metabolites in Selinum tenuifolium collected from different altitudes (2150 m; 2593 m; 3178 m, asl) in Chopta region of Uttarakhand, India. High-performance thin-layer chromatography (HPTLC) fingerprinting, nutrient analysis, and chlorophyll (Chl) content
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In silico approach in the assessment of chromatographic parameters as descriptors of diphenylacetamides’ biological/pharmacological profile J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-10-22 Suzana Apostolov; Dušan Mijin; Slobodan Petrović; Gyöngyi Vastag
Abstract The selected diphenylacetamide derivatives were subjected to chromatographic and in silico approach in order to obtain significant information about their structure-activity relationships. As an early step in the assessment of their biological profile, drug-likeness and lead-likeness rules were performed, as well as determination of the bioactivity scores. The relationships between the obtained
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Challenge to molecular archaeology—Sediments contaminated by allochthonous animal proteins J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-10-27 Jaroslav Pavelka; Ladislav Smejda; Stepanka Kuckova; Petr Mensik
Abstract In this work we proposed a novel methodological approach to detect and differentiate between cooked and uncooked animal meat protein in archaeological samples. We tested two groups of materials: ceramic dated to the early medieval period (9th–10th centuries CE) and soil samples collected from the same stratigraphic layer that yielded these pottery fragments. Using an ELISA immunological test
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Adsorption of mandelic acid enantiomers on chiral stationary phase with grafted antibiotic eremomycin: The effect of the eluent pH J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-04 Elena N. Reshetova
Abstract The adsorption of mandelic acid enantiomers on the Nautilus-E chiral stationary phase with eremomycin as a grafted antibiotic, as affected by p W S H value of the water-ethanol eluent under conditions of an overloaded column, was studied. Adsorption equilibrium under experimental conditions, when mandelic acid dissociates both completely and then very weakly, was studied. The adsorption isotherms
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Effect of temperature variations on non-equilibrium and non-isothermal two-component liquid chromatography in cylindrical columns J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-11-25 Abdulaziz Garba Ahmad; Shamsul Qamar
Abstract The effect of temperature variations in liquid chromatographic columns of cylindrical geometry are studied by formulating a non-isothermal and non-equilibrium two-dimensional (2D) lumped kinetic model (LKM) simulating the flows of two-component mixtures. The developed models contain systems of coupled convection-dominated partial differential, differential, and algebraic equations for mass
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The fabrication of carboxylic acid-functionalized porous layer open tube column and its application in hydrophilic interaction chromatography for small polar molecules J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-11-27 Shiyun Tang; Yuanxing Duan; Feng Chang; Wei Jiang; Fengmei Zhang; Zhihua Liu; Yuting Yang; Chunbo Liu; Yingzhuang Chen
Abstract The porous layer open-tube (PLOT) columns, which were characterized by their considerable specific surface area and high permeability, have attracted a growing attention from researchers in liquid chromatography. In this work, a hydrophilic PLOT column rich in carboxylic acid functional groups was successfully synthesized in capillary with an inner diameter of 200 µm by thermally initiated
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A comparative study of chromatographic lipophilicity and bioactivity parameters of selected spirohydantoins J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-07 Kristina Tot; Anita Lazić; Tatjana Djaković Sekulić
Abstract In this study, lipophilicity of 21 cycloalkylspiro-5-hidantoins was assessed. The overall goal of lipophilicity evaluation is preliminary investigation which should result in a decrease of the traditionally high attrition rates for compounds entering clinical trials. Lipophilicity assessment was done by reversed-phase thin-layer chromatography and in silico methods. Chromatographic analyses
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Magnetic solid phase extraction based on amino acid ionic liquids magnetic graphene oxide nanomaterials-high performance liquid chromatography for the simultaneous determination of Sudan I–IV J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-08 Songqing Chen; Yan Zheng; Zijin Shen; Jiawei Li; Xiashi Zhu
Abstract A tryptophan ionic liquid (TrpIL) decorated magnetic graphene oxide (Fe3O4@SiO2-GO-TrpIL) nanocomposite has been prepared for magnetic solid-phase extraction of Sudan I–IV before their high performance liquid chromatography (HPLC) analysis. Fe3O4@SiO2 nanoparticles loaded on graphene oxide endow the as-prepared nanocomposite with superparamagnetic performance, benefiting conveniently magnetic
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Isolation and purification of soyasapogenol A and B starting from soy hypocotyls: High-speed counter‐current chromatography versus preparative high‐performance liquid chromatography J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-21 Chenghui Pan; Dongyue Qi; Dayun Zhao
Abstract Soyasapogenols derived from soyasaponins, which abundantly occur in soy hypocotyls, are of great importance as bioactive compounds due to their physiological activities. However, there is a lack of a high-efficiency and scalable preparation and isolation procedure. This work extends research on applying and comparing high-speed countercurrent chromatography (HSCCC) and preparative high-performance
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Influence of ionic liquids’ nature on chromatographic retention of benzimidazoles by RP HPLC J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-21 Anastasiya Alexandrovna Yadrova; Oksana Igorevna Grinevich; Roman Vladimirovich Shafigulin; Andzhela Vladimirovna Bulanova
Abstract One of the priority tasks of the pharmaceutical industry is to manufacturing high-quality, effective, and safe medicines. Thus, the interest in for searching biologically active compounds perspective for the creation of new drugs is growing. The aim of this work was to study the chromatographic behavior of benzimidazole and its firstly synthesized derivatives by reversed-phase–HPLC (RP-HPLC)
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Polar polymer-immobilized stationary phase for aqueous reversed-phase liquid chromatography J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-21 Laís de Moura Bife Castilho; Verônica dos Santos Gama; Allyson Leandro Rodrigues dos Santos; Anizio Marcio de Faria
Abstract In this work, a polar stationary phase was prepared by thermal immobilization of poly(glycidoxypropylmethyl-co-dimethylsiloxane) onto silica particles to separate polar compounds using water-rich mobile phases. The retention properties of the stationary phase were characterized by the separation of Tanaka and NIST SRM® 870 test mixtures. The elution order of the compounds indicated the reversed-phase
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A comparison between univariate and multivariate statistical techniques to determine source of pen inks using ultra-performance liquid chromatography (UPLC) chromatograms J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-18 Loong Chuen Lee; Ab Aziz Ishak; Nadirah Abdul Hamid; Yaishnavee Ravi; Muhamad Adib Ahmad; Norazwani Ali
Abstract Forensic ink analyst is frequently asked to determine the source of questioned ink entries. Ultra-performance liquid chromatography (UPLC) technique is useful for profiling organic compounds of pen inks. However, interpreting the UPLC chromatograms requires the use of statistical approaches in order to ensure the objectivity and reliability of the results. This work aims to compare the performances
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Quality assessment and RP-HPLC method development for estimation of curcuminoids in Curcuma longa: A Quality by Design approach J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-09 Vishakha Parab Gaonkar; Kirankumar Hullatti
Abstract The present work aims at developing a QbD assisted RP-HPLC method for the estimation of individual curcuminoids in Curcuma longa rhizomes along with its quality assessment. The quality of crude C. longa sample was evaluated with respect to physicochemical, phytochemical and toxic contaminant analysis. The ATP and CQA’s were identified followed by the optimization of the method by employing
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Magnetic solid phase extraction based on amino acid ionic liquids magnetic graphene oxide nanomaterials-high performance liquid chromatography for the simultaneous determination of Sudan I–IV J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-08 Songqing Chen; Yan Zheng; Zijin Shen; Jiawei Li; Xiashi Zhu
Abstract A tryptophan ionic liquid (TrpIL) decorated magnetic graphene oxide (Fe3O4@SiO2-GO-TrpIL) nanocomposite has been prepared for magnetic solid-phase extraction of Sudan I–IV before their high performance liquid chromatography (HPLC) analysis. Fe3O4@SiO2 nanoparticles loaded on graphene oxide endow the as-prepared nanocomposite with superparamagnetic performance, benefiting conveniently magnetic
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A comparative study of chromatographic lipophilicity and bioactivity parameters of selected spirohydantoins J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-12-07 Kristina Tot; Anita Lazić; Tatjana Djaković Sekulić
Abstract In this study, lipophilicity of 21 cycloalkylspiro-5-hidantoins was assessed. The overall goal of lipophilicity evaluation is preliminary investigation which should result in a decrease of the traditionally high attrition rates for compounds entering clinical trials. Lipophilicity assessment was done by reversed-phase thin-layer chromatography and in silico methods. Chromatographic analyses
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Imidazolium ionic liquid bonded silica stationary phases: Part I: Hexadecylimidazolium stationary phase J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-10-18 Nilushi Paranamana; Ziad El Rassi
Abstract In this first research report, the design of an ionic liquid (IL) silica based stationary phase is described and characterized chromatographically using standard solute probes and via physical measurements including Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA). The stationary phase is hexadecylimidazolium bonded to silica microparticles for the retention of various
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Ultra-performance liquid chromatography (UPLC) for the determination of organic acids – The intermediates of branched-chain amino acid biosynthesis in Escherichia coli strains J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-10-18 Elizaveta N. Fedorova; Darya O. Varlamova; Alexandr D. Kivero; Kristina D. Guk; Leonid R. Ptitsyn
Abstract Simple and rapid reverse-phase ultra-performance liquid chromatography with UV-detection (RP-UPLC-UV) was developed and validated for the simultaneous analysis of 2-isopropylmalate (2-IPM), 3-isopropylmalate (3-IPM), ketoisovalerate (KIV), ketoisocaproate (KIC), and α-keto-β-methylvalerate (KMV) in the culture fluid (CF) of branched-chain amino acid (BCAA) Escherichia coli strain producers
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Imidazolium ionic liquid bonded silica stationary phases. Part II. 1-Ethylimidazolium stationary phase J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-10-12 Nilushi Paranamana; Ziad El Rassi
Abstract In this second research report (i.e., Part II), an ionic liquid (IL)-bonded silica column having an anion-exchange characteristic is described and characterized chromatographically with test acidic solute probes and by physical measurements such as Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA). The IL anion-exchange stationary phase consists of a short alkyl chain
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Plate-model applied on concentration effects in size exclusion chromatography J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-08-07 Miloš Netopilík
A universal procedure of modeling chromatography separation, based on the plate model, has been developed. On each plate, the equilibrium between the analyte in the mobile and stationary phases is established. This equilibrium may be described by the concentration-dependent partition coefficient. The establishment of the equilibrium on each plate is followed by the displacement of the analyte in the
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Protein chromatography by molecular imprinted cryogels J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-07-21 Nilay Bereli; Handan Yavuz; Adil Denizli
Molecularly imprinted cryogels for protein recognition have received much attention in recent years with the development of supermacroporous polymer systems. Molecularly imprinted cryogels, which offer great advantages for the selective and effective purification and separation of biomacromolecules from their sources, have become an important candidate for affinity matrix. Cryogels with their macroporous
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Analytical methodologies for measuring colistin levels in pharmacokinetic studies J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-07-20 Mohd Shafie Zabidi; Ruzilawati Abu Bakar; Nurfadhlina Musa; Wan Nazirah Wan Yusuf
Colistin is an old antibiotic reintroduced in response to an increased incidence of multi-resistant Gram-negative bacterial infections. It has a narrow therapeutic window, and dose optimization is required. Dose optimization requires accurate method of measurement. The goal of this manuscript is to review previously developed methods, their advantages and disadvantages, and problems to be addressed
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Monitoring the changes of 5-caffeoylquinic acid during its reaction with ABTS cation radicals by LC-MS J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-07-20 Małgorzata Olszowy-Tomczyk; Rafał Typek
Reactive oxygen species including free radicals are responsible for noxious changes in living organisms which can be associated with many diseases for e.g. cardiovascular, neurodegenerative, and inflammatory diseases or cancer. In the struggle against free radicals the organism is supported by antioxidants. As they are often provided by nature, they can be considered safe. 5-Caffeoylquinic acid is
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Cloud point extraction as a sample enrichment technique for capillary electrophoresis–An overview J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-07-13 Vamsi Krishna Marothu; Padmalatha K.; Madhavi G.; Lasya K.
Cloud point extraction (CPE) is a simple, inexpensive and green sample enrichment technique for different analytes in different matrices. In this technique surfactant solution is used at concentration above critical micelle concentration to extract the analytes from various matrices. Capillary electrophoresis (CE) and family of related techniques have emerged as powerful analytical techniques for pharmaceutical
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Glycine ionic liquid functionalized β-cyclodextrin polymer high-performance liquid chromatography for the separation/analysis of pyrethroids J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-09-11 Qing Gao; Wei Liu; Xiashi Zhu
Abstract The green glycine ionic liquid functionalized β-cyclodextrin polymer material (AAIL-β-CDCP) was synthesized and characterized with Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM). A novel method of solid phase extraction (SPE) coupled with high-performance liquid chromatography (HPLC) for separaton/detection of pyrethroids (permethrin and fenpropathrin) was
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Multi-residue analysis of organochlorine pesticides and carcinogenic polycyclic aromatic hydrocarbons in Jordanian olive oil using gas chromatography-mass spectrometry J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-09-10 Ibrahim N. Tarawneh; Ahmad A. Najjar; Fayda F. Salameh; Razan S. Bani Issa
Abstract A new simple extraction method has been developed for determination 20 banned organochlorine (OC) pesticide residues and 16 Environmental Protection Agency (EPA) priority pollutant polycyclic aromatic hydrocarbons (PAHs) using gas chromatography equipped with a mass-spectrometric detector (GC-MS). Various extraction processes were studied, the final extraction method was applied by liquid-liquid
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Numerical approximation of a two-dimensional non-equilibrium model of non-isothermal liquid chromatography considering core-shell particles J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-09-10 Abdulaziz Garba Ahmad; Sadia Perveen; Shamsul Qamar
Abstract A nonlinear and non-isothermal two-dimensional lumped kinetic model (2D LKM) is solved numerically to simulate the transport of multi-component mixtures in fixed-bed liquid chromatographic columns of cylindrical geometry packed with core-shell particles. The model considers axial and radial dispersions, interfacial mass, and heat transfers, nonlinear adsorption, and rectangular pulse injections
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Simultaneous determination of five phosphates in dairy products by ion chromatography J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-09-10 Hai-Hua Xie; Lan Guo; Aiping Yan; Fan Liu; Yiqun Wan
Abstract A simple and reliable analytical method was established for the quantitative determination of five phosphates (orthophosphate, pyrophosphate, trimetaphosphate, tripolyphosphate, and hexametaphosphate) in dairy products by ion chromatography (IC). The samples were deproteinized with 2% trifluoroacetic acid, defatted with n-hexane, and then purified on a C18 solid phase extraction cartridge
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Validated green phenyl reversed-phase LC method using ethanol to determine MDMA in seized ecstasy tablets J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-09-04 Leandro Oka Duarte; Bruno Ferreira; Gabriela R. Silva; Antônio J. Ipólito; Marcelo F. de Oliveira
Abstract 3,4-Methylenedioxymethamphetamine (MDMA) is a popular illicit drug. Given its adverse effects, the growing abuse of MDMA worldwide, and the need for forensic chemistry methods that minimize environmental issues, here we report a green approach for quantitative MDMA analysis in ecstasy tablets based on phenyl reversed-phase liquid-chromatography coupled to a diode-array detector. Water with
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Evaluation of pranoprofen photodegradation induced by ultraviolet-light irradiation in aqueous media J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-08-31 Kohei Kawabata; Shiori Akimoto; Masanori Inagaki; Hiroyuki Nishi
Abstract The photodegradation of pranoprofen (PP), which is a member of the 2-arylpropionic acid family of non-steroidal anti-inflammatory drugs, in aqueous media under ultraviolet light (UV) irradiation was studied herein. Our purpose is to clarify the photostability and photochemical behavior of PP. The photodegradation of PP and the generation of its photoproducts were monitored by means of high-performance
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An organic monolithic capillary column functionalized with human serum albumin and its application for the nano – chromatography study of its binding with universal cancer peptides and its impact on immunogenicity J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-08-26 Andre Claire; Lydie Lethier; Yves C. Guillaume
Abstract Sixty picomoles of human serum albumin (HSA) was immobilized on a glycidylmethacrylate (GMA) capillary column previously developed by our group to study its binding with two universal cancer peptides (UCPs). Zonal HPLC experiments demonstrated that UCP2 and UCP4 have 1:1 interaction at the well-known site I of HSA with similar affinities in the micromolar range. At pH 7.4 UCP2 and UCP4 bound
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Plate-model applied on concentration effects in size exclusion chromatography J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-08-07 Miloš Netopilík
A universal procedure of modeling chromatography separation, based on the plate model, has been developed. On each plate, the equilibrium between the analyte in the mobile and stationary phases is established. This equilibrium may be described by the concentration-dependent partition coefficient. The establishment of the equilibrium on each plate is followed by the displacement of the analyte in the
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Chromatographic fingerprinting of some basils and the evaluation of their antioxidant properties with chemometric calculations J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-08-06 Anna Hawrył; Mirosław Hawrył
Abstract The quality of 12 basils (Ocimum basilicum L.) extracts was evaluated based on content of phenolics, antioxidant activity, high-performance liquid chromatography (HPLC) fingerprint combined with chemometrics. Evaluation of antioxidant activity was performed using DPPH technique and total phenolic was determined using Folin–Ciocalteau reagent. Highest antioxidant activity was obtained for O
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A study on the determination of two related aminothiols in the brain of diabetes rats by HPLC-ECD J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-08-06 Jian-Sha Li; Dan Huang; Hong-Mei Qiu; Qing-Song Jiang; Yong-Hong Liu; Ting-Ting Du; Xin-Hui Jiang
Abstract A high-performance liquid chromatography-electrochemical detection method was developed to determine the concentration of homocysteine and cysteine in the diabetes mellitus Sprague-Dawley male rats’ cortex and hippocampus. The cortex and hippocampus of control and diabetes model rats were collected. After pretreatment, the analysis of total homocysteine and cysteine were performed on a C8
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Determination of veterinary drug residues in food of animal origin: Sample preparation methods and analytical techniques J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-08-06 Shuling Li; Qiongyao Zhang; Mengdi Chen; Xuejiao Zhang; Ping Liu
Abstract Veterinary drugs are widely used in animal husbandry to prevent and treat animal diseases, to promote animal growth, and to improve the conversion rate of feed. However, the use of veterinary drugs in food-producing animals may leave residues of the parent compounds, and/or their metabolites in food products resulting in harmful effects to humans. To ensure food safety, sensitive and effective
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Magnetic field-assisted solid-phase extraction of nucleoside drugs using Fe3O4@PANI core/shell nanocomposite J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-08-05 Nahid Heidari; Alireza Ghiasvand; Sana Abdolhosseini; Leila Ghaedrahmati; Abdullah Barkhordari; Vahid Jalili
Abstract A new magnetic field-assisted solid-phase extraction (MFA-SPE) procedure was developed by merging the features of magnetic solid-phase extraction and magnetic in-tube solid-phase microextraction. The MFA-SPE method was coupled with HPLC-UV and applied for the separation and determination of anti-HIV drugs in biological fluids. Magnetic Fe3O4@PANI nanocomposite with core/shell structure was
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A sensitive micellar liquid chromatographic method for the rectification of enantiomers of esmolol, and determination of absolute configuration and elution order J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-07-31 Vijay Alwera; Suman Sehlangia; Shiv Alwera
Abstract A green chromatographic method is proposed for the enantioseparation of Esmolol (Amino alcohol) in which aqueous solution of the mixed surfactants is used as the alternative of organic solvents. In this work, the diastereomeric derivatives of racemic esmolol were prepared, under microwave heating conditions, using highly reactive activated chiral esters of the (S)-levofloxacin, (S)-ketoprofen
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Progress in the analytical research methods of polycyclic aromatic hydrocarbons (PAHs) J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-05-23 Qiongyao Zhang; Ping Liu; Shuling Li; Xuejiao Zhang; Mengdi Chen
Polycyclic aromatic hydrocarbons (PAHs) are one species of persistent organic pollutants (POPs) with strong carcinogenicity and teratogenicity. They can be widely found in the environment, which cause great harm to the ecological environment. In addition, they endanger human health by polluting food from the natural environment and food processing. Therefore, it is necessary to accurately detect PAHs
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Analytical methodologies for measuring colistin levels in pharmacokinetic studies J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-07-20 Mohd Shafie Zabidi; Ruzilawati Abu Bakar; Nurfadhlina Musa; Wan Nazirah Wan Yusuf
Colistin is an old antibiotic reintroduced in response to an increased incidence of multi-resistant Gram-negative bacterial infections. It has a narrow therapeutic window, and dose optimization is required. Dose optimization requires accurate method of measurement. The goal of this manuscript is to review previously developed methods, their advantages and disadvantages, and problems to be addressed
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Analytical method development and validation of anticancer agent, 5-fluorouracil, and its metabolites in biological matrices: An updated review J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-07-02 Nadhiratul-Farihin Semail; Aemi Syazwani Abdul Keyon; Bahruddin Saad; Siti Salmah Noordin; Nik Nur Syazni Nik Mohamed Kamal; Nur Nadhirah Mohamad Zain; Juzaili Azizi; Sazlinda Kamaruzaman; Noorfatimah Yahaya
5-fluorouracil (5-FU) refers to a fluorinated pyrimidine analogue that has been widely used as an anticancer agent for colon, head, and neck cancers. Detection of 5-FU and its metabolites; 5-fluorouridine and 5-fluoro-2-deoxyuridine in biological samples allows optimization of pharmacotherapy and encourages fundamental investigations of this medication. The development of accurate and reliable sample
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A sensitive RP-HPLC method for estimation of artemether from polymeric nanoparticles after pre-column acid treatment using UV-visible detector J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-06-22 Atharva R. Bhide; Dhanashree H. Surve; Sonia Guha; Anil B. Jindal
Artemether; a sesquiterpene lactone is widely used for the treatment of malaria as artemisinin-based combination therapy (ACT). The present work involves the development and validation of sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method for quantification of artemether (ART) in polymeric nanoparticles. ART was transformed to α, β-unsaturated decalones by pre-column acid
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Isolation, identification, biological estimation, and profiling of glucosinolates in Isatis indigotica roots J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-06-22 Qihui Guo; Yanzhi Sun; Qingjiu Tang; Hongchao Zhang; Zhihong Cheng
Four main glucosinolates (progoitrin, epiprogoitrin, gluconapin, and neoglucobrassicin) were isolated and identified from Isatis indigotica roots (Isatidis Radix). Among these, neoglucobrassicin was the first indole glucosinolate isolated from this herb, and its structure was elucidated by NMR, MS, and X-ray diffraction analysis. The glucosinolate components of Isatidis Radix have been profiled by
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Bioassay screening of 12 Iranian plants and detection of antibacterial compounds from Heracleum persicum using a TLC bioautography method J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-05-23 Hossein Dehghan; Parizad Rezaee; Atousa Aliahmadi
Allium paradoxum, Buxus hyrcana, Convolvulus persicus, Cyclamen coum, Eryngium caucasicum, Heracleum persicum, Pimpinella affinis, Parrotia persica, Primula heterochroma, Pyrus boissieriana, Ruscus hyrcanus, and Smilax excelsa are some medicinal and food flavoring plants found in the Hyrcanian forests in Iran. This study was designed to determine the most potent antibacterial compounds from the plants
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Structure–retardation factor relationship of natural amino acids in two different mobile phases of RP-TLC J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-06-19 Saeed Yousefinejad; Fatemeh Honarasa; Samira Akbari; Mohsen Nekoeinia
Separation of amino acids (AAs) and their simple and inexpensive determination/identification is an interesting topic in biological and protein science, different food industries, and drug factories. Also, the presentation of the chromatographic behavior of compounds in a predictive model can be effective to estimate the structural/chemical properties of analyte and mobile phases. In this work for
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Chromatographic and computational lipophilicity assessment of novel antibiofilm agents J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-06-19 Jovana Krmar; Ana Protić; Nevena Đajić; Mira Zečević; Biljana Otašević
In this study, lipophilicity of five newly designed molecules with antibiofilm properties was estimated for the first time. The overall goal of lipophilicity evaluation in lead generation phase is to decrease the traditionally high attrition rates for compounds entering clinical trials. Lipophilicity was assessed using RP-HPLC and in silico methods. Chromatographic analyses were performed on BDS Thermo
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Separation and indirect ultraviolet detection of common fluorine-containing anions by ionic liquids in reversed-phase chromatography J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-06-18 Yuan Guo; Zhen-jie Yin; Yi-meng Sun; Hong Yu
A new approach for the simultaneous separation and indirect ultraviolet detection of four common fluorine-containing anions using 1-hexyl-3-methylimidazolium chloride as a mobile phase additive in reversed-phase chromatography was developed. The principle of separation and detection is that fluorine-containing anions and imidazolium cations form ion-pairs with ultraviolet absorption. Under the optimal
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New forced degradation products of vildagliptin: Identification and structural elucidation using LC-MS, with proposed formation mechanisms J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-06-16 Sharif Arar; Enas Al-Qudah; Muhammad Alzweiri; Kamal Sweidan
A new and simple RP-HPLC-UV method was developed for well-separation of vildagliptin raw material and its degradation products at different conditions; it uses of ammonium acetate buffer at pH= 7.5 and methanol with Athena C18 -WP (250 mm) column. Results show that six degradants have been identified using LC–MS technique, in addition to the NMR approach in some cases. One degradant at relative retention
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Screening and quantifying the quality markers of DuHuo by fingerprint modeling J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-05-29 Liu Yang; Ajiao Hou; Yanping Sun; Song Wang; Jiaxu Zhang; Hai Jiang
With environmental health and safety becoming a concern for people, supercritical fluid chromatography has been regarded as a “green chemistry” method that gradually has peaked people’s interest. The purpose of this study was to establish a method to screen and quantify the quality markers of Duhuo (DH) through an environmentally friendly ultra-performance convergence chromatography (UPC2) method.
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Screening and quantifying the quality markers of DuHuo by fingerprint modeling J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-05-29 Liu Yang; Ajiao Hou; Yanping Sun; Song Wang; Jiaxu Zhang; Hai Jiang
With environmental health and safety becoming a concern for people, supercritical fluid chromatography has been regarded as a “green chemistry” method that gradually has peaked people’s interest. The purpose of this study was to establish a method to screen and quantify the quality markers of Duhuo (DH) through an environmentally friendly ultra-performance convergence chromatography (UPC2) method.
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Extraction and simultaneous determination of metoprolol and α-hydroxy metoprolol in latent fingerprints by liquid chromatography tandem mass spectrometry J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-04-23 Wen-Ji Zhang; Zi-Qing Lin; Wei Zhang; Ying-Jian Xu; Ji-Long Zheng
A simple extraction and sensitive simultaneous analysis method for metoprolol and its metabolite alpha-hydroxy metoprolol in latent fingerprint using liquid chromatography-mass spectrometry was developed. The extraction procedure was optimized as scrubbing using cotton swabs for 30 times followed by ultrasonic assistance in 30 °C methanol for 5 min with power of 2000 W. Drug analysis was performed
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Comparative elucidation of phenolic compounds in Albanian olive oils using LC-DAD-ESI-MS/MS J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-01-09 Dritan Topi; Gamze Guclu; Hasim Kelebek; Serkan Selli
Olive oils may provide health benefits, including the prevention of coronary heart diseases, cancers, and the modification of immune and inflammatory responses. These benefits mainly originate from the phenolic compounds found in olive oil. There has been no study on the advanced characterization of Albanian olive oils from various cultivars regarding phenolic compounds. Hence, a comprehensive characterization
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Migration of pseudoestrogen bisphenol A from various types of paper with thermochromic prints to artificial sweat solutions J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2019-12-24 Kristinka Vinković; Marina Vukoje; Mirela Rožić; Nives Galić
Thermochromic inks, materials that change color at a certain temperature, are increasingly used on papers and other materials in the areas of design, commercials, and security printing. Pseudo-estrogen bisphenol A (BPA) may be one of their main compounds present in mass fractions of up to several percent. In this work, the mass fractions of BPA in thermochromic prints on seven types of paper were determined
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Metabolomics analysis of human plasma metabolites reveals the age- and sex-specific associations J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2019-12-23 Yixiao Wang; Guangshu Wang; Ru’nan Jing; Ting Hu; Sergei Likhodii; Guang Sun; Edward Randell; Guihua Jia; Tianmiao Yu; Weidong Zhang
Objectives: The objective of this study was the investigation of age- and sex-associations in a set of blood plasma metabolites in healthy male and female subjects. Methods: A comparison study design with male and female subjects of various ages was used. Metabolic profiling was performed using electrospray ionization tandem mass spectrometry that yielded 186 metabolite concentrations for each study
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Comprehensive classification of USA cannabis samples based on chemical profiles of major cannabinoids and terpenoids J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2019-12-18 Ramia Z. Al Bakain; Yahya S. Al-Degs; James V. Cizdziel; Mahmoud A. Elsohly
Different USA-origin cannabis samples were analyzed by GC-FID to quantify all possible cannabinoids and terpenoids prior to their clustering. Chromatographic analysis confirmed the presence of seven cannabinoids and sixteen terpenoids with variable levels. Among tested cannabinoids, Δ9-Tetrahydrocannabinol Δ9-THC and cannabinol CBN were available in excess amounts (1.2–8.0 wt%) and (0.22–1.1 wt%),
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UPLC-MS/MS method for the determination of acrylic acid in tap water J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2019-12-18 Hao Zhang; Juan Wei; Zongli Huo
A simple and rapid method employing ultra-high performance liquid chromatography tandem mass spectrometry has been developed for the direct determination of acrylic acid in tap water for the first time. The method worked on a ultra-high-performance liquid chromatography system and utilized the direct injection of 10 μL volumes. Aqueous samples were filtered with 0.22 μm membrane after diluting with
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Positively charged covalent organic framework and its application in the dispersive solid-phase extraction of ultraviolet-filters from food packaging material migrants J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2019-12-18 Yanxin Li; Hongzhan Liu; Xia Wu; Ting Wu; Chunpeng Qiu; Shijuan Zhang; Huihui Liu
Covalent organic frameworks (COFs) show excellent property, such as high porosity and excellent structure stability and were well applied in fields such as catalysis and adsorption, but most of the COFs showed similar structure and thus similar adsorption performance. Modification of simple COFs to enhance its adsorption performance in separation technique is an important issue. In this study, quaternary
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Numerical solution of nonlinear and non-isothermal general rate model of reactive liquid chromatography J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2019-11-08 Nadia Kiran; Sadia Perveen; Fouzia A. Sattar; Shamsul Qamar
Abstract A nonlinear general rate model (GRM) of liquid chromatography is formulated to analyze the influence of temperature variations on the dynamics of multi-component mixtures in a thermally insulated liquid chromatographic reactor. The mathematical model is formed by a system of nonlinear convection–diffusion reaction partial differential equations (PDEs) coupled with nonlinear algebraic equations
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Rapid analysis of 14 ultraviolet absorbents in plastic food contact materials by supercritical fluid chromatography on Sub-2-micron particles J. Liq. Chromatogr. Relat. Technol. (IF 0.992) Pub Date : 2020-04-02 Yue Qiu; Yan Ruan; Chao-Lan Tan; Gen-Rong Li; Mei Long; Zhi-Ning Xia
A rapid and reliable method based on supercritical fluid chromatography (SFC) technology was established for the analysis of 14 ultraviolet (UV) absorbents in plastic food contact materials. The separation was optimized by employing different chromatographic conditions including stationary phases, organic modifiers, column temperatures and back pressures to achieve appropriate selectivity and resolution