样式: 排序: IF: - GO 导出 标记为已读
-
Estimation of Shatavarin IV and Sarsasapogenin from the roots of Asparagus racemosus Wild using validated HPLC-ELSD method optimized using QbD approach J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2024-03-04 Nishit Patel, Manish Nandpal, Archita Patel, Samir Patel, Manan Raval
The plant Asparagus racemosus Wild is mentioned in Ayurveda and used commercially alone or as an ingredient of many poly-herbal formulations indicated as a tonic and to improve the functioning of t...
-
Ultra-performance liquid chromatography-tandem mass spectrometry for quantification of pyrethroid pesticide residues in freshwater fish and shrimp J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2024-03-05 Lulu Wang, Yuanxu Shi, Xiangjie Pan, Yunxuan Li, Tianshu Li, Ying Chen, Jiaqi Zhang, Huadong Sheng, Shuifeng Zhang
A sophisticated Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) approach was devised for the concurrent quantification of pyrethroid pesticide residues in freshwater f...
-
Development of a validated bioanalytical method for the simultaneous estimation of ornidazole and miconazole in rat plasma by LC-MS/MS and its application to a pharmacokinetic study J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2024-02-28 Subhradip Roychoudhury, Swadesh Kumar Pattanik, Rojalini Samanta, Ghanshyam Panigrahi, Swaha Satpathy, Mohsin Kazi, Muhammad Delwar Hussain, Arjun Patra, Kishanta Kumar Pradhan
A highly sensitive, accurate, and robust LC-MS/MS method was developed and validated for the simultaneous determination of ornidazole (ODZ) and miconazole (MCZ) in rat plasma using metronidazole (M...
-
Non-distructive chromatographic determination of a surface area in reverse phase chromatographic columns J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2024-02-20 Margaret Figus, Yuri V. Kazakevich
One of the critical but underutilized parameters that affect chromatographic separation is an adsorbent surface area (S.A.). We introduce a concept of direct determination of the total surface area...
-
Chromatographic characterization of new spirohydantoins derived from β-tetralone J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2024-01-10 Tatjana Djaković Sekulić, Anamarija Mandić, Anita Lazić
A series of spirohydantoin derivatives synthesized in our laboratory have been analyzed by reversed-phase liquid chromatography. Retention data obtained in two chromatographic modes (TLC and HPLC) ...
-
Development and validation of simultaneous HPLC-PDA analysis method for quality control of Hwang-ryeon-hae-dok-tang: An analytical quality by design approach J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2024-01-03 Geonha Park, Seung Hyeon Go, Sejin Ku, Min Kyoung Kim, Young Pyo Jang
This study introduces an advanced analytical method for quality control of botanical drugs, focusing on Hwang-ryeon-hae-dok-tang (HRHDT), a traditional herbal prescription utilized for inflammation...
-
Elucidating the active ingredients and potential anti-inflammatory mechanism of Qingwei Huanglian Wan J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-27 Liqiu Yan, Fangfang Liu, Yanyang Zhang, Erbing Wang, Tingli Qu
Qingwei Huanglian Wan (QHW) is a traditional Chinese medicine used for treating inflammation. As the compositions of QHW preparations are complex and varied, it has proven difficult to identify the...
-
Emerging approaches for the detection of trimethylamine N-oxide: A gut derived metabolite J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-13 Anjumariya Kottarathil, Divya Sangeetha Rajkumar, Rajashree Padmanaban
Trimethylamine N-oxide (TMAO) is a gut-derived compound that has been linked to the development of cardiovascular disease and other health conditions. The detection of TMAO in biological samples is...
-
Application of TLC-smartphone method for the analysis of carbamazepine in plasma J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-13 Mohamed Ali Soussi, Youssef Mallek, Wiem Ben Ayed, Slah eddine Liouane, Wahiba Douki
A new, simple, rapid, low-cost, and robust thin layer chromatography-smartphone method has been developed for the qualitative and quantitative determination of carbamazepine in human plasma. Liquid...
-
A modern chromatographic energy-saving approach for the analysis of doxycycline, ambroxol, and its precursor and impurity: Green metric assessment and comparison J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-13 Selvia M. Adly, Mohamed A. Elsayed, Safa’a M. Riad, Hany H. Monir
The ternary mixture of doxycycline hyclate (DOX), ambroxol hydrochloride (AMB), and ambroxol synthetic precursor and process impurity (IMP) as chemically identified in the British Pharmacopeia as 2...
-
Correction J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-13
Published in Journal of Liquid Chromatography & Related Technologies (Vol. 46, No. 16-20, 2023)
-
A novel UHPLC-MS/MS method for trace level identification and quantification of genotoxic impurity 2-(2-chloroethoxy) ethanol in quetiapine fumarate J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-13 Mahammad Ali Shaik, Krishna Moorthy Manchuri, Devanna Nayakanti
A selective and sensitive new reversed-phase method was developed and validated by using Waters Acquity UHPLC system coupled with Waters Micromass Quattro PremierXE (MS/MS) to identify and quantify...
-
A rapid and eco-friendly method for determination of dictamnine, obacunone, and fraxinellone in Cortex Dictamni by LC–MS and matrix solid-phase dispersion extraction J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-13 Zhengming Qian, Qinggui Lei, Chuanxi Wang, Qi Huang, Wenqing Li, Wenhao Wang
This study develops a rapid and eco-friendly liquid chromatography–mass spectrometry method for determining dictamnine, obacunone, and fraxinellone in Cortex Dictamni. The samples were extracted by...
-
Eco-friendly design of experiment based approach for estimation of azelnidipine and olmesartan medoxomil in RP-HPLC: Greenness appraisal J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-13 Naveenarani Dharuman, Lakshmi Karunanidhi Santhana, Manikandan Krishnan
The analytical chemistry community has prioritized the implementation of green analytical methods in recent years to minimize the adverse effect on the environment and human beings. The combination...
-
Efficient and reliable CE-SDS separations by the high-speed turbo CE-SDS® cartridge J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-13 Robert Minkner, Udo Burger, Louis Malz, Susanne Doerks, Hermann Wätzig
Capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) is a modern form of SDS-PAGE that uses capillary electrophoresis to separate proteins by size. The technique is based on the sieving effect...
-
Application of capillary electrophoresis-sodium dodecyl sulfate in assessing the purity of monoclonal antibody biopharmaceuticals J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-07 Xiaoyue Song, Huairu Tian, Guolin Zhang
Monoclonal antibodies (mAbs) are emerging biopharmaceuticals that have drawn great public attention due to their potential to treat many thorny diseases such as cancers, infections, autoimmune diso...
-
Novel chromatographic methods for fingerprinting the bioactive constituents of herbal medicines used as hepatoprotective and adaptogenic in herbo-mineral regimen J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-03 Manali Patel, Charmy Kothari, Shital Panchal, Krishna Bhalodi
Shilajit, along with Triphala, has been one of the most widely used herbal drug combinations for the symptomatic treatments of hyperthyroidism. However, the high polarity difference among active co...
-
A green reversed phase HPLC and HPTLC methods and their validation for simultaneous estimation of remogliflozin, vildgliptin and metformin in fixed dose combination formulation J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-03 Kamini Sethy, Gopal Krishna Padhy, Raja Rajeswari Katta
To estimate remogliflozin, vildagliptin and metformin in a new fixed dose combination two chromatographic methods were developed and validated. The initial method is a green RP- HPLC method which u...
-
Antioxidant profiles of 19 lemon balm extracts by high-performance thin-layer chromatography–radical scavenging assay versus respective microtiter plate assay J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-12-03 Ágnes M. Móricz, Virág Lapat, Gertrud E. Morlock
The antioxidant profiles of 19 lemon balm leaf samples collected in Hungary and extracted with methanol were investigated by videodensitometric high-performance thin-layer chromatography–1,1-diphen...
-
In memoriam Prof. Emeritus Dr. Joseph A. Sherma, Jr J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-11-25 Prof. Habil. Dr. Claudia Cimpoiu
Published in Journal of Liquid Chromatography & Related Technologies (Ahead of Print, 2023)
-
Applying machine learning on high-performance thin-layer chromatography using the complementary developing solvents concept J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-11-24 Thi Kieu Tiên Do, Ilona Trettin, Mona Hänni, Eike Reich
Predicting chromatographic results is a difficult task for many analysts, especially in Thin-Layer Chromatography (TLC) where reproducibility is always a critical point. The availability of suitabl...
-
Effect-directed profiling of bee pollen versus propolis J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-11-23 Gertrud E. Morlock, Fang Yang
Natural bee products are increasingly used in cosmetics, health products, and food supplements. Bee pollen and propolis are quite different products, although the processing by the bees is for the ...
-
High-performance liquid chromatography with fluorescence detection method for measuring colistin in human serum and its application in critically ill patients treated with colistin methanesulfonate sodium J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-09-29 Mohd Shafie Zabidi, Ruzilawati Abu Bakar, Nurfadhlina Musa, Suzana Mustafa, Wan Nasrudin Wan Ismail, Siti Nur Aziela Ab Manap, Nur Aishah Che Mohd Zaid, Wan Nazirah Wan Yusuf
Colistin, in the form of colistin methanesulfonate sodium (CMS), has a narrow therapeutic window, and colistin levels must be monitored during treatment. The aim of this study was to develop and va...
-
Exploring the relationship between blueberry size and antioxidant content J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-09-08 Jake A. Cravino, Richard Thomas, Gareema Pandey, Corey W. Manwaring, Sophie E. Parks, Ross Andrew Shalliker
Abstract Blueberries are a widely consumed superfood, known for their potent phytochemical content and health benefits. Given their importance to the global food market and the current health culture, blueberries are the focal point of much inquiry into their composition, physiological benefits, and the effect of growing conditions on the quality of the final berry. Given their complex nature and the
-
Separation of betulin and its derivatives by high-performance liquid chromatography and their determination in extracts of some plants and chaga mushroom J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-08-30 Viktoria V. Sursyakova, Vladimir A. Levdansky, Anatoly I. Rubaylo
Abstract The influence of conditions on the separation of betulin (BT), betulinic (BIA), and betulonic (BOA) acids by reversed-phase high-performance liquid chromatography (RP-HPLC) with isocratic elution was studied. It was shown that the order of peaks in chromatograms changed with varying the acetonitrile (ACN) content in the mobile phase, and a poor separation under certain conditions was observed
-
Determination of aflatoxins using chromatographic methods in several foods, feed and herbal medicine products: an analytical review (from 2010 to 2022) J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-08-18 Rahul Koli, V. S. Mannur
Abstract Aflatoxins are naturally occurring secondary metabolites generated by several molds, particularly Aspergillus flavus and Aspergillus parasiticus. They can contaminate agricultural products in the field, particularly during periods of high humidity and warmth, such as before or during harvest, or as a result of inappropriate storage, and their occurrence in the food chain is regrettably inevitable
-
Speciation and determination of inorganic antimony in tea infusion by using solid-phase extraction-based liquid chromatography-inductively coupled plasma-mass spectrometry J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-07-30 Jiacai Hu, Xiuming Lv, Hao Zhang, Baoli Zhu, Deye Liu, Wenliang Ji
Abstract In this work, we developed a method to separate and detect inorganic antimony (iSb) in tea infusions based on liquid chromatography-inductively coupled plasma-mass spectrometry (LC-ICP-MS). Considering that iSb was present in tea infusions in trace amounts, a commercial solid-phase extraction (SPE) column was employed to enrich iSb(III) and iSb(V). In this study, we found that iSb exists in
-
Extracting antioxidants from blueberries J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-07-30 Jake A. Cravino, Corey W. Manwaring, Jonathan G. H. Stathakis, Ross Andrew Shalliker
Abstract Blueberries are widely consumed for their flavor and complex array of antioxidants and other beneficial phytochemicals. Central to studies on blueberries is the ability to extract antioxidants. For appropriate analysis, the extracted compounds must represent those contained in the blueberry without bias or loss of information. Given the complex array of phytochemicals present, extracting these
-
Study of the scale isolation of anthocyanins from blue corn by flash chromatography J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-07-22 Naella S. Valencia Pérez, Aristeo Garrido Hernández, Francisco J. Martínez Valdez, Genaro I. Cerón Montes, Roberto García Rosales, Jorge Yáñez Fernández
Abstract In the current work, a flash chromatography method was developed to separate the main anthocyanins of blue corn; cyanidin-3-glucoside (Cy3G), peonidin-3-glucoside (Pn3G), and cyanidin-3-(6-malonylglucoside) (Cy3MG). These anthocyanins were identified by mass spectroscopy analysis. The implemented method consisted of the isocratic elution in a two-step mixture of methanol: water: acetic acid
-
Food, drug and model mix analysis by organic monolithic columns based on heterocyclic monomers J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-07-17 Yulia S. Sotnikova, Yuri V. Patrushev
Abstract This paper presents examples of separation on monolithic columns prepared by two different methods: copolymerization and post-modification. In the first method, monoliths were prepared from styrene, divinylbenzene, and heterocyclic nitrogen-containing monomers. In the second, a styrene/divinylbenzene/4-vinylbenzyl chloride copolymer was obtained and in situ modified with 1-methylimidazole
-
Chemometrically assisted evaluation of isatine derivatives’ chromatographic and computational descriptors J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-07-06 Suzana Apostolov, Dominik Brkić, Gyöngyi Vastag
Abstract The first phase of the evaluation of the biological profile of novel isatin derivatives included the theoretical verification of their drug-likeness and lead-likeness properties. In the second phase, chromatographic parameters (RM0, m and C0) were determined using RPTLC in the presence of four different organic modifiers. Linear regression and multivariate analysis were used to examine the
-
One-step pre-column derivatization method for HPLC-UV determination of organic acids in fruit juices J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-28 Nada Seddiq, Adem Asan
Abstract A simple and effective one-step pre-column derivatization method for reversed-phase HPLC-UV determination of the major organic acids (citric, malic, tartaric, and succinic acids) in fruit juices has been developed. The method is based on the coupling reaction of organic acids with 1-naphthylamine in the presence of N,N′-diisopropylcarbodiimide. The resulting organic acid amide derivatives
-
Synthesis and characterization of pH-sensitive thin-layer molecularly imprinted membranes for selective solid-phase extraction of celecoxib from biological fluids followed by high-performance liquid chromatography with UV detection J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-28 Negin Yazdanian, Behrouz Akbari-Adergani, Maryam Kazemipour, Mehran Javanbakht, Homayon Ahmad Panahi
Abstract In this work, the synthesis of thin-layer, pH-sensitive molecularly imprinted membrane using methacrylic acid and maleic acid as functional monomers, ethylene glycol dimethacrylate as cross-linker, 2,2′-azobisisobutyronitrile as initiator, poly (vinylidene fluoride) as porous membrane, and celecoxib as a target molecule have been reported. Different technique analyses characterized the membrane
-
A HPLC method for simultaneous quantification of chlorhexidine and thymol using Box-Behnken design for robustness of the method assessment J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-29 Vanessa Morais Muniz, José Venâncio Chaves Júnior, Cícero Flávio Soares Aragão, Fábio Santos de Souza, Fábio Correia Sampaio
Abstract The antimicrobial chlorhexidine is considered the gold standard in dentistry. Thymol is a phenol found in the essential oils of various plant species and also stands out for its antimicrobial potential. Synergistic effects can be promoted by applying these two active pharmaceutical ingredients together in technological products, for example in controlled release microparticles. The objective
-
Integrated methods for fingerprinting of monofloral honeys J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-22 Alina Tarna, Claudia Cimpoiu, Anamaria Hosu
Abstract Honey is an important functional food due to its content of polyphenolic compounds with beneficial effects on human body. The analysis of polyphenolic compound in honey is very promising in determination of floral origin and so for quality control. This study approaches a new methodology using integrated methods for the determination of honey authenticity. Polyphenolic compounds from seven
-
Library-based UHPLC-Q-exactive-orbitrap-MS putative identification of isomeric and non-isomeric bioactives from Zibushengfa Tablet and pharmacopeia quality-marker chemistry J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-21 Shaoman Chen, Xican Li, Jingyuan Zeng, Rongxin Cai, Chunhou Li, Chuanbing Chen
Abstract Zibushengfa Tablet is a widely consumed traditional Chinese medicine (TCM) prescription. However, its main bioactives remain unclear and its pharmacopeia quality-marker (Q-marker) is poorly characterized nowadays. The present study analyzed its lyophilized aqueous powder using ultra-high-performance liquid chromatography-quadrupole-orbitrap mass spectrometry. Through comparison with authentic
-
Advances on analysis methods of ginkgo biloba leaf extract J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-21 Jinhao Li, Jing Lan, Shufang Wang, Jianbiao Yao, Fangfang Wang, Xingchu Gong
Abstract Ginkgo biloba leaf extract (EGBL) is a valuable herbal extract. The main active ingredients are flavonoids, terpene lactones, organic acids and proanthocyanidins. In recent years, there have been many reports on the detection of the above active ingredients. In this paper, the analysis methods of chemical components in EGBL were reviewed, such as ultraviolet spectrophotometry, high-performance
-
Development of UPLC-MS/MS methods for quantitation of glutathione, cysteine, 14,15-epoxyeicosatrienoic acid, and 15-hydroxyeicosatetraenoic acid and application in paraquat poisoning cells J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-15 Congrong Tang, Xingjie Zhu, Zheng Yu, Xiaofang Ke, Jianhui Yang, Zhongqiu Lu, Lufeng Hu
Abstract Glutathione (GSH) and cysteine are important antioxidants in maintaining the oxidation-reduction balance. 14,15-epoxyeicosatrienoic acid (14,15-EET) and 15-hydroxyeicosatetraenoic acid (15-HETE) are biological active compounds metabolized from arachidonic acid. To dynamically monitor GSH, cysteine, 14,15-EET, and 15-HETE, an ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS)
-
Comparative evaluation of solid-phase extraction and in-tube liquid-liquid extraction for the determination of Organophosphorus pesticides in the surface water from Medjerda River, Tunisia J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-10 Mouna Necibi, Nadia Mzoughi
Abstract In the present work, we develop, validate, and compare two extraction procedures (in-tube liquid-liquid extraction (ITLLE) and solid-phase extraction (SPE)). The parameters that influence extraction efficiency, the nature and volume of the extraction solvent, as well as the pH nature, were improved and a standard solution of Organophosphorus pesticides (OPPs) was used. Results indicated that
-
TLC densitometric analysis of triple antibiotic therapy; Erythromycin, Sulfadiazine and Trimethoprim in different edible chicken tissues J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-09 Marco M. Z. Sharkawi, Mark T. Safwat, Eglal A. Abdelaleem, Nada S. Abdelwahab
Abstract Erythromycin (ERY) is one of the macrolides used abundantly in veterinary medicines to treat various infections including respiratory, skin and bones. Combination of sulfadiazine (SFD) and trimethoprim (TMP) has proven efficacy and is widely used in the treatment of many infectious diseases, due to the efficiency of SFD as a bactericidal and TMP as a bacteriostatic. On the other hand, those
-
Metabonomics comparison of coronary heart disease with and without turbid phlegm syndrome J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-06-08 Xiaofeng Wang, Jing Wang, Guligena Sawuer, Min Jiang, Xueqin Zhai, Hui Fan, Yaonan Du, Pengcheng Zhu
Abstract Objectives To help understand the pathogenesis of coronary heart disease (CHD) by doing blood metabonomics comparison on CHD patients with phlegm-turbidity syndrome and without syndrome, and healthy controls. Methods Ninety patients were involved. Among them, 60 patients with CHD were divided into the coronary heart disease with turbid phlegm syndrome group (HZTZ) and the coronary heart disease
-
Uncovering the Q-marker and potential mechanisms of Qishan Formula for lung cancer based on multi-technology J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-05-31 Yutong Sui, Yanqun Yang, Jing Zhang, Ziwei Wang, Xue Geng, Jiakang Jiang
Abstract Qishan Formula (QSF) is mainly used to treat lung cancer and its side effects of radiotherapy and chemotherapy. Although the clinical efficacy of QSF has been recognized, its mechanism of action and active ingredients are still unclear. This study aims to explore the potential Q-Marker of QSF and reveal its anti-lung cancer mechanism. Firstly, the fingerprints of 10 batches of QSF were established
-
Study on binding affinity profile, bioactivity, and lipophilicity of selected antipsychotic drugs J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-05-25 Melinda Szasz, Dorina Casoni, Claudia Cimpoiu
Abstract Schizophrenia is a complex mental illness that affects almost 1% of the population and has no curative treatment. Currently, available neuroleptic drugs have severe limitations and induce drug-related adverse effects. Receptor binding affinity parameters and lipophilicity are important characteristics that describe the bioactivity of these drugs. Lipophilicity is an important physicochemical
-
Simultaneous monitoring of ceftaroline fosamil and its active form ceftaroline during stability study of commercial sample - a new stability-indicating HPLC method, drug decomposition in clinical use conditions and degradation products by LC-MS J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-05-25 Paula de Oliveira Moretto, Graciela Carlos, Fábio de Souza Barbosa, Cássia V. Garcia, Tiago Franco de Oliveira, Andreas S. L. Mendez
Abstract Ceftaroline fosamil (prodrug) and ceftaroline (active form; degradation product) were simultaneously determined by a new stability-indicating HPLC method. These two forms were monitored during stability investigation of drug formulation reconstituted solution following the same conditions used for clinical use (refrigeration and room temperature). In general terms, ceftaroline fosamil is stable
-
A Platform analytical method for intact polysorbates in protein-containing biopharmaceutical products via HPLC-CAD J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-05-12 Katie A. Carnes, Lee D. Oliver Jr., Timothy A. Brown, Roberto F. Delgadillo, Michelle S. Ward, Sina Mortazavi, Michael J. Morris, Justin W. Shearer, Joshua S. Fuller
Abstract Polysorbate (also known as “Tween”) 80 (PS80) is the most common surfactant in biopharmaceuticals. Here, we report a sensitive, and specific platform analytical method using reversed-phase high performance liquid chromatography employing a charged aerosol detector (HPLC-CAD), that offers the ability to quantitate intact PS80 and can distinguish between low recovery of PS80 and degraded PS80
-
Holistic chemical characterization of Zaoren Anshen preparations based on HPLC fingerprint and multi-components quantification J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-05-08 Manjiang Xie, Jie Wang, Chenguang Dong, Pengfei Tu, Qingying Zhang
Abstract Based on HPLC fingerprint analysis and multi-components quantification, a simple, sensible, and reliable HPLC-UV method, capable of qualitatively and quantitatively characterizing the main chemical markers of all medicinal herbs of Zaoren Anshen (ZRAS) prescription by one injection, was firstly developed. Then, three different dosage forms of ZRAS preparations, i.e., capsule, granule, and
-
Hydrophilic molecularly imprinted chitosan microspheres based on deep eutectic solvents for micro-solid phase extraction of catechin J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-05-04 Mengdi Yuan, Chenglin Zhong, Kyung Ho Row, Guizhen Li
Abstract Hydrophilic molecularly imprinted chitosan microspheres (HMICS) were synthesized using deep eutectic solvents (DESs)-(3-aminopropyl) triethoxysilane (APTES) as co-functional monomer for the extraction of catechin from green tea with micro-solid phase extraction (micro-SPE). Various factors were studied to optimize the extraction condition during extraction process. The actual extraction amount
-
A comprehensive review on QbD driven analytical procedures developed for the analysis of various drugs J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-05-04 Aggarapu Susmitha, Galla Rajitha, Gireesh Kumar Eri
Abstract Quality has been a prime priority for the pharmaceutical sector with the development of recommendations by regulatory organizations like ICH. Concepts of ICH Q8 to Q10 are the foundation of the QbD methodology, a systematic approach to pharmaceutical development. Pharma industries have adopted the QbD approach to support product quality during manufacturing and to improve robust manufacturing
-
Differential compounds of licorice before and after honey roasted and anti-arrhythmia mechanism via LC-MS/MS and network pharmacology analysis J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-05-03 Lujie Lu, Wenxin Wang, Peijun Sun, Shuwei Yan, Huixian Chen, Xiao Liu, Jiajia Dong, Lihong Chen, Tulin Lu
Abstract Licorice is mainly used to treat cough in clinics. After being roasted with honey, licorice has a cardiac protective effect. Due to its different sources, the chemical components in licorice are also diverse. To distinguish the different compounds between three sources of raw licorice (RL) and between three sources of honey-roasted licorice (HRL), a UPLC-QTOF-MS/MS method was established.
-
A DoE-based fast and synchronous quantification of rhein, aceclofenac, and diclofenac by RP-HPLC-DAD method in spiked Wistar rat plasma: application to pharmacokinetic studies J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-05-03 Taufik M. Kazi, Panchaxari M. Dandagi, Prakash R. Biradar
A fixed-dose combination of diacerein and aceclofenac (ACF) is commonly used in the treatment of osteoarthritis for their disease-modifying and analgesic effects, respectively. We introduce a simpl...
-
Development of a stability-indicating HPLC method for the simultaneous quantification of antazoline nitrate and naphazoline sulfate in a commercial ophthalmic formulation J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-04-22 Mohammed Ali Salih, Kosar Hikmat Hama Aziz, Dlivan Fattah Aziz, Hilal Demir Kivrak
Abstract In this work, an RP-HPLC method was established for the simultaneous quantification of antazoline sulfate and naphazoline nitrate in commercial ophthalmic formulations. The proposed method was validated for sensitivity, selectivity, linearity, accuracy, precision, and stability, and was found to be suitable for routine analysis of these two active ingredients in the presence of degradation
-
Determination of ointments active ingredients and parabens by one analytical method – capillary GC with cool-on-column injection and FID detection J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-04-20 Anna Ioutsi, Lybov Utkina, Mikhail Sumtsov
In the field of quality control of medicines every pharmaceutical is tested for compliance with the requirements of the normative document for this drug to assess the quality. Among the quality ind...
-
Application of Box-Behnken design for optimization of A RP-HPLC method for determination of palonosetron and netupitant in their combined dosage form in presence of their impurities J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-04-18 Mohamed A. ElHamid, Ehab F. ElKady, Eman A. Mostafa
Abstract The use of (Netupitant and Palonosetron) combination to treat nausea and vomiting in cancer chemotherapy patients has been authorized by the Food and Drug Administration. For the simultaneous determination of Netupitant (NET) and palonosetron (PAL) in the presence of two of their related substances and in their dosage form, a sensitive and selective RP-HPLC method has been developed and validated
-
Separation techniques for intact antibody analysis by mass spectrometry J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-04-17 Nicole A. Schneck, Kshitij Khatri, Matthew D. Maust, Mark E. Jennings II, Julien Peltier, John F. Kellie
Abstract The possibilities to directly couple different separation methods with mass spectrometry (MS) for the analysis of intact proteins has attracted significant attention over the last decade. While sample preparation is critical for MS analyses, coupling an efficient separation method before MS can significantly improve the ability to resolve protein heterogeneity and reveal intact masses or higher-order
-
Determination of vitamins B1 and B6 in infant formula and food supplement samples using magnetic layered double hydroxide nanoadsorbent before liquid chromatography-tandem mass spectrometry J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-04-17 Monireh Zamani-Kalajahi, Ali Abolhassani, Samin Hamidi, Mahboob Nemati
Abstract A magnetic Mg/Fe layered double hydroxide (magnetic LDH) nanocomposite was successfully prepared and used as a suitable adsorbent to simultaneously extract vitamins B1 and B6 from complex infant formula and food supplements. The important parameters affecting the extraction were optimized and the final parameters are as follows; the amount of adsorbent (20 mg), extraction time (6 min), elution
-
Determination of clobetasol propionate in cosmetics by high performance liquid chromatography with pre-column fluorescence derivatization of 4-hydrazino-7-nitrobenzo [C] [1,2,5] oxadiazole J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-04-09 Hai-Wen Zhang, Jie Wang, Chang-Zhao Wang, Chun-Mei Guo, Jin-Zhu Chen, Xue-Min Xiong, Qi-Dong Tu, Xin Qin, Da-Yong Peng
Abstract In this study, a fluorescent labeling reagent 4-hydrazino-7-nitrobenzo [c] [1,2,5] oxadiazole (NBD-NHNH2) was synthesized and used for fluorescence detection of clobetasol propionate in cosmetics by high performance liquid chromatography. In the presence of acidic catalyst (pH = 6.0), NBD-NHNH2 reacted at 45 °C for 30 min, and clobetasol propionate can be labeled quickly and efficiently. These
-
An HP-TLC densitometric method and fingerprinting for estimating capecitabine and thymoquinone simultaneously and its application in nanoscience using Box–Behnken design J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-03-01 Prasiddhi Raikar, P. M. Dandagi, Amruta Balekundri
Abstract World Health Organization estimates that 10% of medications are of inferior quality, thus dangerous to human health. One way to avoid such a problem is to create an adequate, economical, and competitive analytical system. As a result, the study’s goal is to create a High-Performance Thin Layer Chromatography (HP-TLC) method for determining capecitabine (CAP) and thymoquinone (TQ) simultaneously
-
Simultaneous quantification of multiple active components of the ginkgo ketoester tablet when combined with donepezil in four biological matrices from an Alzheimer’s animal model: Evaluation of drug distribution patterns in vivo J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-02-28 Wen-Xia Pi, Xiao-Yu Huan, Yu Zhuang, Jing Zhang, Xu-Qin Shi, Gui-Sheng Zhou
Abstract Ginkgo ketoester tablets (GT) and donepezil are clinically used in combination to treat Alzheimer’s disease (AD). This study aimed to investigate the anti-dementia effects of two drugs alone and in combination by monitoring the distribution patterns of their active components in different biological matrices. A practical analytical method was developed for simultaneously quantifying 38 active
-
Bioactive mushroom polysaccharides: The structure, characterization and biological functions J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-02-23 Solehah Mohd Rosdan Bushra, Asma Abdullah Nurul
Abstract Medicinal mushrooms are conventionally used in the traditional medicine to treat or prevent illnesses. Polysaccharides are an important component in the mushrooms, a major contributor in their biological properties, and have been extensively studied since the past two decades. Medicinal mushrooms contain a class of polysaccharide known as β-glucan that possesses various biological activities
-
Rapid screening of undeclared hypoglycemics in counterfeit herbal antidiabetic products using HPTLC-MS J. Liq. Chromatogr. Relat. Technol. (IF 1.3) Pub Date : 2023-02-02 Diva C. Purohit, Jigna Vadalia, Hardi Joshi, Udaykumar G. Vegad
Abstract Adulterating herbal and dietary supplements with synthetic hypoglycemics is widely practiced, especially in developing and undeveloped countries. A simple, precise, and novel method was developed to simultaneously determine synthetic antidiabetics belonging to different classes, namely biguanide, sulfonylurea, and thiazolidinedione, in counterfeit herbal products as adulterants using HPTLC-MS