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Reconciling the pHe measurements of bioethanol: pHabs measurements of buffered 50-50 wt% water-ethanol mixtures Anal. Chim. Acta X Pub Date : 2022-06-22 L. Deleebeeck, A. Snedden, D. Stoica
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Electrochemical application of cobalt nanoparticles-polypyrrole composite modified electrode for the determination of phoxim Anal. Chim. Acta X Pub Date : 2021-09-21 Molla Tefera, Merid Tessema, Shimelis Admassie, Meryck Ward, Lisebo Phelane, Emmanuel I. Iwuoha, Priscilla G.L. Baker
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Differential light scattering and the measurement of molecules and nanoparticles: A review Anal. Chim. Acta X Pub Date : 2021-07-02 Philip J. Wyatt
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Volatile free liquid membranes for electromembrane extraction Anal. Chim. Acta X Pub Date : 2021-02-18 Andrea Šlampová, Pavel Kubáň
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Ex vivo Comprehensive Multiphase NMR of Whole Organisms: A Complementary tool to in vivo NMR Anal. Chim. Acta X Pub Date : 2020-11-01 Rajshree Ghosh Biswas, Blythe Fortier-McGill, Mohammad Akhter, Ronald Soong, Paris Ning, Monica Bastawrous, Amy Jenne, Daniel Schmidig, Peter De Castro, Stephan Graf, Till Kuehn, Falko Busse, Jochem Struppe, Michael Fey, Hermann Heumann, Holger Boenisch, Marcel Gundy, Myrna J. Simpson, André J. Simpson
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Experimental determination of the Bioluminescence Resonance Energy Transfer (BRET) Förster distances of NanoBRET and red-shifted BRET pairs Anal. Chim. Acta X Pub Date : 2020-11-01 Felix Weihs, Jian Wang, Kevin D.G. Pfleger, Helen Dacres
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Analysis of total microcystins and nodularins by oxidative cleavage of their ADMAdda, DMAdda, and Adda moieties Anal. Chim. Acta X Pub Date : 2020-11-01 Amanda J. Foss, Christopher O. Miles, Alistair L. Wilkins, Frode Rise, Kristian W. Trovik, Kamil Cieslik, Mark T. Aubel
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ANOVA Simultaneous Component Analysis: a tutorial review Anal. Chim. Acta X Pub Date : 2020-11-01 Carlo Bertinetto, Jasper Engel, Jeroen Jansen
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Oligonucleotide Hybridization with Magnetic Separation Assay for Multiple SNP Phasing Anal. Chim. Acta X Pub Date : 2020-07-01 Henson L. Lee Yu, Tsz Wing Fan, I-Ming Hsing
Since humans have two copies of each gene, multiple mutations in different loci may or may not be found on the same strand of DNA (i.e., inherited from one parent). When a person is heterozygous at more than one position, the placement of these mutations, also called the haplotype phase, (i.e., cis for the same strand and trans for different strands) can result in the expression of different amount
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Evaluation of CRM homogeneity in cases of insufficient method repeatability: comparison of Bayesian analysis with substitutes for ANOVA based estimates Anal. Chim. Acta X Pub Date : 2020-07-01 Thomas P.J. Linsinger
Insufficient method repeatability is a problem characterising the evaluation of certified reference materials (CRMs). In investigating the homogeneity studies of 216 certified parameters from 36 CRMs released by the European Commission’s Joint Research Centre (JRC) over the last four years, it was found that in 1/3 of the cases, the method repeatability (sr) was too high to calculate the standard deviation
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Selective pressurized liquid extraction of plant secondary metabolites: Convallaria majalis L. as a case Anal. Chim. Acta X Pub Date : 2020-03-01 Xiaomeng Liang, Nikoline Juul Nielsen, Jan H. Christensen
A fast and efficient selective pressurized liquid extraction (sPLE) method was developed to extract secondary metabolites from complex plant matrix. Convallaria majalis L., a plant producing toxic steroids, was used as proof-of-concept. The method was optimized in the aspects of preheating, dispersant, extraction temperature and solvent, and the use of C18 as in-cell cleanup sorbent. Eight authentic
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New planar assay for streamlined detection and quantification of β-glucuronidase inhibitors applied to botanical extracts Anal. Chim. Acta X Pub Date : 2020-03-01 Ehab Mahran, Michael Keusgen, Gertrud E. Morlock
The inhibition of the β-glucuronidase released from gut bacteria is associated with specific health-related benefits. Though a number of β-glucuronidase inhibition assays are currently in use, none of them can directly measure the relevant activity of each single constituent in a complex mixture, without prior separation and tedious isolation of the pure compounds. Thus, the hyphenation of the high
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Development of an analytical methodology based on fabric phase sorptive extraction followed by gas chromatography-tandem mass spectrometry to determine UV filters in environmental and recreational waters Anal. Chim. Acta X Pub Date : 2020-03-01 Maria Celeiro, Ruben Acerbi, Abuzar Kabir, Kenneth G. Furton, Maria Llompart
A novel method based on fabric phase sorptive extraction (FPSE) followed by gas chromatography-tandem mass spectrometry (GC-MS/MS) has been validated for the simultaneous determination of 11 UV filters (ethylhexyl salicylate, benzyl salicylate, homosalate, benzophenone-3, isoamylmethoxycinnamate, 4-methylbenzylidenecamphor, methyl anthranilate, etocrylene, 2-ethylhexylmethoxycinnamate, 2-ethylhexyl
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Red blood cells membrane micropolarity as a novel diagnostic indicator of Type 1 and Type 2 Diabetes Anal. Chim. Acta X Pub Date : 2019-11-01 Giada Bianchetti, Flavio Di Giacinto, Dario Pitocco, Alessandro Rizzi, Gaetano Emanuele Rizzo, Francesca De Leva, Andrea Flex, Enrico di Stasio, Gabriele Ciasca, Marco De Spirito, Giuseppe Maulucci
Classification of the category of diabetes is extremely important for clinicians to diagnose and select the correct treatment plan. Glycosylation, oxidation and other post-translational modifications of membrane and transmembrane proteins, as well as impairment in cholesterol homeostasis, can alter lipid density, packing, and interactions of Red blood cells (RBC) plasma membranes in type 1 and type
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Non-faradaic electrochemical impedimetric profiling of Procalcitonin and C-reactive protein as a dual marker biosensor for early sepsis detection Anal. Chim. Acta X Pub Date : 2019-11-01 Ambalika Sanjeev Tanak, Badrinath Jagannath, Yashaswee Tamrakar, Sriram Muthukumar, Shalini Prasad
In this work, we demonstrate a robust, dual marker, biosensing strategy for specific and sensitive electrochemical response of Procalcitonin and C-reactive protein in complex body fluids such as human serum and whole blood for the detection of sepsis. Enhanced sensitivity is achieved by leveraging the physicochemical properties of zinc oxide at the electrode-solution interface. Characterization techniques
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An “on-off” SERS Aptasensor Based on DNAzyme-Gold Nanorod for Ultrasensitive Pb2+ Detection in Human Serum Anal. Chim. Acta X Pub Date : 2019-07-01 Wei Xu, Aiwu Zhao, Fangtao Zuo, Hafiz Muhammad Jafar Hussain, Ranjha Khan
It is great significance to precisely monitor lead (II) ions (Pb2+) for environment protection and human health monitoring. We designed a sensitive detection strategy for sensitive and selective determination of Pb2+, based on a Pb2+-specific DNAzyme as the catalytic unit, Cy3-labeled DNA modified gold nanorods (AuNRs) as SERS reporter. Firstly, AuNRs surface were employed as a platform for the immobilization
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Influencing the selectivity of grafted anion exchangers utilizing the solubility of the radical initiator during the graft process Anal. Chim. Acta X Pub Date : 2019-07-01 Achim Kaltz, Lea Bohra, Jonathan S. Tripp, Andreas Seubert
A previously published radical graft-functionalization method for the synthesis of high performance anion exchangers was further investigated to control the capacity and selectivity of the exchangers. Using a hydrophobic radical initiator instead of a hydrophilic one diminished the influence of rivaling homopolymerization of monomer during the functionalization step. Instead of only generating monomer
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Analytical considerations in tsing laser ablation mhe determination of uranium isotope ratios in solid uranium materials uulti-collector ICP-MS Anal. Chim. Acta X Pub Date : 2019-07-01 Michael Krachler, Zsolt Varga, Adrian Nicholl, Klaus Mayer
Validated analytical measurement protocols for the fast and accurate determination of the uranium (U) isotopic composition (234U, 235U, 236U, 238U) of solid nuclear materials were developed employing ns-laser ablation (LA) coupled to multi-collector ICP-MS. The accuracy of the analytical procedure was assured by frequent (n = 65) analysis of a pressed pellet of certified isotopic reference material
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Evaluation of the selectivity of G-quadruplex ligands in living cells with a small molecule fluorescent probe Anal. Chim. Acta X Pub Date : 2019-07-01 Suge Zhang, Hongxia Sun, Dawei Yang, Yan Liu, Xiufeng Zhang, Hongbo Chen, Qian Li, Aijiao Guan, Yalin Tang
G-quadruplex has been an emerging target for drug design due to its physiologically important roles in oncology. A number of quadruplex-interactive ligands have been developed by synthetic and medicinal chemists over the past decades. However, the great challenge still remains that the method for detecting the specific targeting of these ligands to the G-quadruplex structures in cells is still lacking
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Rational Design of Mixtures for Chromatographic Peak Tracking Applications via Multivariate Selectivity Anal. Chim. Acta X Pub Date : 2019-07-01 Daniel W. Cook, Kelson G. Oram, Sarah C. Rutan, Dwight R. Stoll
Chromatographic characterization and parameterization studies targeting many solutes require the judicious choice of operating conditions to minimize analysis time without compromising the accuracy of the results. To minimize analysis time, solutes are often grouped into a small number of mixtures; however, this increases the risk of peak overlap. While multivariate curve resolution methods are often
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An electrochemical study of acrylate bone adhesive permeability and selectivity change during in vitro ageing: a model approach to the study of biomaterials and membrane barriers Anal. Chim. Acta X Pub Date : 2019-07-01 M. Raja, J.C. Shelton, F. Salamat-Zadeh, M. Tavakoli, S. Donell, G. Watts, P. Vadgama
This study assessed the solute permeability of a family of UV and moisture cured acrylates-based adhesives during in vitro ageing in pH 7.4 buffer. Acrylates have a potential role in bone fracture fixation, but their inability to allow microsolute exchange between the fractured bone surfaces may contribute to ineffective healing. Cyclic voltammetry and chronoamperometry were used to determine the diffusion
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SERS Detection of Clostridium botulinum Neurotoxin Serotypes A and B in Buffer and Serum: Towards the Development of a Biodefense Test Platform Anal. Chim. Acta X Pub Date : 2019-03-01 China Y. Lim, Jennifer H. Granger, Marc D. Porter
Botulinum neurotoxins (BoNTs) are classified at a highest degree of threat in biodefense, due largely to their high lethality. With the growing risk of biowarfare, the shortcomings of the gold standard test for these neurotoxins, the mouse bioassay, have underscored the need to develop alternative diagnostic testing strategies. This paper reports on the detection of inactivated Clostridium botulinum
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Origin of the selectivity differences of aromatic alcohols and amines of different n-alkyl chain length separated with perfluorinated C8 and bidentated C8 modified silica hydride stationary phases Anal. Chim. Acta X Pub Date : 2019-03-01 Chadin Kulsing, Yada Nolvachai, Maria T. Matyska, Joseph J. Pesek, Joshua Topete, Reinhard I. Boysen, Milton T.W. Hearn
Perfluorinated C8-(PerfluoroC8) and bidentate anchored C8-(BDC8)-modified silica hydride stationary phases have been employed for the isocratic separation of homologous phenylalkanols and phenylalkylamines differing in their n-alkyl chain length, using aqueous-acetonitrile (ACN) mobile phases of different ACN contents from 10 to 90% (v/v) in 10% increments. These analytes showed reversed-phase (RP)
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On the Mechanism of Protein Supercharging in Electrospray Ionisation Mass Spectrometry: Effects on Charging of Additives with Short- and Long-chain Alkyl Constituents with Carbonate and Sulphite Terminal Groups Anal. Chim. Acta X Pub Date : 2019-03-01 Eric D.B. Foley, Muhammad A. Zenaidee, Rico F. Tabor, Junming Ho, Jonathon E. Beves, William A. Donald
Small organic molecules are used as solution additives in electrospray ionisation mass spectrometry (ESI-MS) to increase the charge states of protein ions and improve the performance of intact protein analysis by tandem mass spectrometry. The properties of the additives that are responsible for their charge-enhancing effects (e.g. dipole moment, gas-phase basicity, Brønsted basicity, and surface tension)
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Extraction of Hydrophobic Analytes from Organic Solution into a Titanate 2D-Nanosheet Host: Electroanalytical Perspectives Anal. Chim. Acta X Pub Date : 2019-03-01 Wulan Tri Wahyuni, Budi Riza Putra, Christian Harito, Dmitry V. Bavykin, Frank C. Walsh, Philip J. Fletcher, Frank Marken
Titanate nanosheets (single layer, typically 200 nm lateral size) deposited from aqueous colloidal solution onto electrode surfaces form lamellar hosts that bind redox active molecular redox probes. Here, hydrophobic redox systems such as anthraquinone, 1-amino-anthraquinone, deca-methylferrocene, 5,10,15,20-tetraphenyl-21H,23H-porphine manganese (III) chloride (TPPMnCl), and α-tocopherol are shown
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Investigations into the interaction thermodynamics of TRAP-related peptides with a temperature-responsive polymer-bonded porous silica stationary phase Anal. Chim. Acta X Pub Date : 2019-03-01 Jamil Chowdhury, Reinhard I. Boysen, Milton T.W. Hearn
The interaction thermodynamics of the thrombin receptor agonistic peptide (TRAP-1), H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-OH, and a set of alanine scan substitution peptides, have been investigated with an n-octadecylacrylic polymer-bonded porous silica (Sil-ODA18) and water-acetonitrile mobile phases at temperatures ranging from 5 to 80 °C in 5 °C increments. The retention of these peptides on the Sil-ODA18
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Procedures for systematic capture and management of analytical data in academia Anal. Chim. Acta X Pub Date : 2019-03-01 Jan Potthoff, Pierre Tremouilhac, Patrick Hodapp, Bernhard Neumair, Stefan Bräse, Nicole Jung
Data management in universities is a challenging endeavor in particular due to the diverse infrastructure of devices and software in combination with limited budget. Nevertheless, in particular the analytical measurements and data sets need to be stored if possible digitally and in a well-organized manner. This manuscript describes how scientists can achieve a data management workflow focusing on data
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Potential Of Ion Mobility-Mass Spectrometry For Both Targeted And Non-Targeted Analysis Of Phase Ii Steroid Metabolites In Urine Anal. Chim. Acta X Pub Date : 2019-03-01 Maykel Hernández-Mesa, Fabrice Monteau, Bruno Le Bizec, Gaud Dervilly-Pinel
In recent years, the commercialization of hybrid ion mobility-mass spectrometers and their integration in traditional LC-MS workflows provide new opportunities to extend the current boundaries of targeted and non-targeted analyses. When coupled to LC-MS, ion mobility spectrometry (IMS) provides a novel characterization parameter, the so-called averaged collision cross section (CCS, Ω), as well as improves
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Automated supervised learning pipeline for non-targeted GC-MS data analysis Anal. Chim. Acta X Pub Date : 2019-03-01 Kimmo Sirén, Ulrich Fischer, Jochen Vestner
Non-targeted analysis is nowadays applied in many different domains of analytical chemistry such as metabolomics, environmental and food analysis. Conventional processing strategies for GC-MS data include baseline correction, feature detection, and retention time alignment before multivariate modeling. These techniques can be prone to errors and therefore time-consuming manual corrections are generally