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Polydopamine-Modified Magnetic Nanoparticles (Fe3O4@PDA) for the Copper-Catalyzed Ipso-Hydroxylation of Arylboronic Acids and Subsequent O-Benzylation in Aqueous Media Lett. Org. Chem. (IF 0.8) Pub Date : 2024-03-14 Kwang-Beom Lee, Ueon Sang Shin, Seung-Hoi Kim
: A novel advancement has emerged in the realm of catalysis with the development of an innovative method for the ipso-hydroxylation of arylboronic acids. This approach harnessed the power of bio-compatible polydopamine-coated magnetite support (Fe3O4@PDA) in conjunction with a copper salt, forming a heterogeneous catalytic environment. The resulting catalytic system facilitated oxidative hydroxylation
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Effective Synthesis of N-Alkyl-3-(Indol-3-yl)Pyrazoles from Ag2CO3-Catalyzed Regioselective Aza-Michael Addition of 5-(Indol-3-yl)-1HPyrazoles Lett. Org. Chem. (IF 0.8) Pub Date : 2024-03-12 Xue Zhang, Dashuang Luo, Xuemin Niu, Jian Mo, Haifeng Yu, Xiaobo Zhao
: In this study, the synthesis of N-alkyl-3-(indol-3-yl)pyrazoles was carried out from Ag2CO3 catalyzed regioselective aza-Michael addition of 5-(indol-3-yl)-1H-pyrazoles to a, bunsaturated carbonyl compounds. In the presence of 10 mol% of Ag2CO3, the reaction smoothly occurred in dichloroethane (DCE) at 120oC to preferentially afford a series of N-alkyl-3-(indol-3- yl)pyrazoles in high yields with
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Identification and Synthesis of Oxidative-Degradation and Starting Materials-Attributed Impurities in Lisdexamfetamine Dimesylate Lett. Org. Chem. (IF 0.8) Pub Date : 2024-03-05 Suryabhan B. Chaugule, Pradip L. Gole, Siddhesh Haldankar, DVP Kishore, Nilesh L. Bonde, Sandeep A. Kotharkar
: Impurities are an integral part of drug substances, even though they have not been studied in the pharmacological evaluation of the Benefit-Risk (BR) profiles. Hence, understanding their origin and controlling them have prime importance during drug substance development. The structures of some of the impurities in lisdexamfetamine dimesylate, a central nervous system stimulant drug, have been confirmed
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Cholesterol-Based B-Ring 2H-Pyran: Synthesis and Reaction Mechanism by Using Density Functional Theoretical Study Lett. Org. Chem. (IF 0.8) Pub Date : 2024-03-01 Priyanka -, Himanshi Kumar, Kamlesh Sharma
: The steroidal B-ring 2H-pyran 2 is synthesized by reacting steroidal B-ring α,β- unsaturated ketone 1 and 2-cyano-N-methylacetamide by refluxing for 18 h in methanol in the presence of a catalyst, i.e., chitosan. The product is obtained with a yield of 67%. The structure of the final product 2 is confirmed by utilizing IR, Mass, 13C and 1H NMR spectra. The reaction mechanism of the steroidal pyran
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[EMIM] [OAc]: An Efficient Ionic Liquid Medium for the Synthesis of New 4-(furan/pyrrole/thiophene-2-yl)-3, 4-dihydro-1H-chromeno [4,3- d]pyrimidine-2,5-diones and Molecular Docking Studies Lett. Org. Chem. (IF 0.8) Pub Date : 2024-03-01 Siva Prakash Pullagura, Arunkumar Thiriveedhi, Venkateswara Rao Battula, Raghunadh Akula, A. Sajeli Begum, Lakshmi Soukya P.S.
: An efficient synthesis of Chromeno[b]pyrimidine derivatives 4 has been achieved by treating 4-hydroxy-2H-chromen-2-one 1, furan-2-carbaldehyde / 1H-pyrrole-2-carbaldehyde/ thiophene-2- carbaldehyde 2, and urea/thiourea 3 at 65-70 °C for 90-120 min using 1-Ethyl-3-methylimidazolium acetate as ionic liquid and medium with good yields 86-90%. This synthetic method has numerous advantages, including
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Fireballs-Like Explosive Peroxides Produced by the Brown-rot Fungus Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-27 Gerson S. Paiva
: Fireballs are unusual and rare phenomena usually associated with thunderstorms, although sometimes they have been observed during earthquakes, volcano eruptions or in fair weather. There are still questions about their origination, features and interaction with the environment. In this work, a new model is shown to explain the formation of fireballs in fair weather from poplar cotton and peroxides
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Apigenin Bioisosteres: Synthesis and Evaluation of their Antioxidant, Antimicrobial, and Anticancer Activities Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-27 Juhi Gupta, Kalyani Thombre, Krishna Gupta, Milind Umekar
: A novel series of Apigenin bioisosteres [1(4-chlorophenyl)-3-phenyl prop-2-ene-1-one] non-cyclic derivatives (4a-4c) and [7-hydroxy-2-phenyl-4H-chromen-4-one] cyclic derivatives (9a- 9d) were synthesized. The newly synthesized apigenin bioisosteres were confirmed using UV, IR, NMR, and mass spectroscopic methods. The antioxidant, antibacterial, and anti-cancer activities of all newly synthesized
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Selective Hydrogenation Reaction: Utilizing a Microreactor for Continuous Flow Synthesis of Nickel Nanoparticles Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-27 Vivek Srivastava
Introduction:: In this investigation, we employed a continuous flow reactor to synthesize nickel (Ni) nanoparticles exhibiting uniform size distribution and excellent stability. Our focus centered on exploring the impact of reactant dilution and flow rate on the synthesis process. Result:: It was observed that the optimization of these parameters played a pivotal role in obtaining small-sized Ni nanoparticles
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Recent Advances in Biginelli Reaction using Nanoparticles, Zeolites and Metal Compounds as Catalyst: A Concise Review Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-22 Bhaktiben R Bhatt, Dr. Bharat C. Dixit, Dr. Vipul B. Kataria, Dr. Ritu B. Dixit, Shaffiq Saiyad
:: The year 1891 is considered as a historic year in chemical science due to the introduction of novel heterocyclic compounds by P. Biginelli. The classical Biginelli reaction offers 3,4- dihydropyrimidin-2(1H)-ones/thiones in occupancy of acids like Broansted and Lewis. Multifaceted Dihydropyrimidones (DHPMs) have gained much importance due to their high biological activities. Several nanoparticles
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A Simple and Efficient Path for the Synthesis Antineoplastic Agent (2R,3R,4S,5R)-5-(6-Amino-2-Chloropurin-9-yl)-4-Fluoro-2-(Hydroxymethyl) oxolan-3-ol (Clofarabine) Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-22 Laxmi Kumari Nagarapu, Chithaluri Sudhakar, Suresh Babu Namani
: Clofarabine (1) is an anticancer agent used to treat acute leukemia. This work discloses the efforts to develop a convenient, environmentally benign, and high-yielding synthetic protocol leading to Clofarabine (1). The synthesis includes bromination of 2-deoxy-2-β-fluoro-1,3,5-tri-O-benzoyl-1- α-D-ribofuranose (6), followed by C-N coupling with a 2,6-dichloro purine (4) and selective amination consecutively
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A Linear and Stereoselective Approach for the Synthesis of Dapoxetine from Benzaldehyde Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-22 Ramakoteswara Rao Chinta, Kumaraswamy Paridala, Vijay Kumar Tulam
: In addition to providing a succinct pathway for the stereoselective synthesis of dapoxetine, a potent SSRI employed in the treatment of premature ejaculation, this study highlights the strategic use of Ellman's sulfinamide as a chiral auxiliary. The key method involves the diastereoselective allylation of (S,E)-N-Benzylidenesulfinamide, resulting in the desired S-configuration critical for the pharmacological
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Catalyst-free Approach to Dihydropyrimidones Using Glycerol/Ethyl Lactate as a Recyclable and Biodegradable Promoting Medium Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-12 Smriti Kushwaha, Swastika Singh, Jyoti Baranwal, Archana Jyoti
:: A variety of dihydropyrimidone compounds were synthesised using an effective one-pot, multicomponent, environmentally friendly reaction of aromatic aldehydes, urea/thiourea, ethyl acetoacetate, and glycerol/ethyl lactate. To the best of our knowledge, this is the first catalyst-free strategy for the synthesis of this key scaffold with medicinal chemistry applications. Other significant aspects of
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Exploring the Supramolecular Features, Computational Studies, and Molecular Docking Studies of a Carbamate Schiff Base Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-02 Sibel Demir Kanmazalp, Necmi Dege, Nabajyoti Baildya, Suman Adhikari
: In the carbamate Schiff base compound, the molecule is stabilized by intramolecular hydrogen bonding interactions along with π···π stacking and C–H···π contacts that lead to the molecule generating diverse supramolecular architecture. The fingerprint plots associated with Hirshfeld surface analysis indicate that the most important contributions for the crystal packing are from H⋯H/H⋯H (81.8%), H⋯O/O⋯H
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Thiourea-Ammonium Chloride Mediated Knoevenagel Condensation as an Intermediate in the Synthesis of Pyrimidine Scaffolds under Solvent-free Condition Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-02 A. M. Rayate, M. R. Gaware
: In this paper, we have reported solvent solvent-free method for Knoevenagel condensation reaction of various aldehydes with active methylene compounds using thiourea and ammonium chloride. The developed method demonstrated high efficiency in the formation of C-C bond. The reaction proceeds smoothly under mild and solvent-free conditions and the products obtained are in excellent yield in very short
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Mild and efficient synthesis of para-substituted 2-hydroxymethyl piperazine.... Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-02 Zijian Liang, Liyuan Guo, Qian Li, Chunyan Liu, Chao Liu, Shi Wu
Herein, we present a mild and effective synthetic method for preparing para-substituted 2-hydroxymethyl piperazine from serine methyl ester and L-amino acids with residues of different sizes. This synthetic route has several advantages including mild reaction conditions, availability of reagents, non-racemic composition, and the potential for gram-scale synthesis. Notably, the compound (4g) demonstrated
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Treatment of Reactive Orange 16 Dye-Bearing Wastewater by Electro-Fenton Process with Stainless-Steel Electrodes: Statistical Optimization and Operational Analysis Lett. Org. Chem. (IF 0.8) Pub Date : 2024-02-01 Imran Ahmad, Debolina Basu
: In the current work, the Electro-Fenton (EF) based Reactive Orange 16 (RO16) dye treatment was studied and compared with central composite (CC) and Taguchi design (TD) statistical optimization tools. Color removal (RC) and COD decay (RCOD) were chosen responses for the effect of pH (A), electrolysis time (B), initial dye concentration (C), and current density (D). The facecentred CC design and L16
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Facile Synthesis and Antitumor Activity of o-Iodoaromatic Ether Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-29 Xiaoxia Mao, Yuying Zhang, Keyang Wang, Guiqin Zhao, Dejun Zhou, Zhengguo Cui
: In this study, an efficient method for the synthesis of one type of aromatic ether was introduced, and its antitumor activity was investigated. Specifically, (diacetoxyiodo)arene was prepared from 2-methyliodobenzene and used to oxidize the 4-nitrophenol to give the aromatic ether. Our study further found that aromatic ether has a strong apoptotic effect on U937 monocytes, suggesting that it might
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Novel Amide Functionalized Trifluoromethyl thieno[2,3-b]pyridine Derivatives: Anti-cancer Activity and Molecular Docking Studies Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Sailu Betala, Naveen Puram, Udayasri Bhanothu
: Our primary research objective is to create and formulate small ring heterocycles with enhanced biological efficacy. Amide functionalized trifluoromethyl thieno[2,3-b]pyridine derivatives as a series were prepared starting from reaction between 1,3 di-ketone and thiocyanoacetamide and obtained pyridine 3. Compound 3 reacts with bromoethyl acetate and obtained compound 4, further compound 4 on reaction
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An Effective Algorithm Based on Sequence and Property Information for N4-methylcytosine Identification in Multiple Species Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Lichao Zhang, Xueting Wang, Kang Xiao, Liang Kong
: N4-methylcytosine (4mC) is one of the most important epigenetic modifications, which plays a significant role in biological progress and helps explain biological functions. Although biological experiments can identify potential 4mC sites, they are limited due to the experimental environment and labor-intensive process. Therefore, it is crucial to construct a computational model to identify the 4mC
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1,2,4-Triazole-conjugated Fluoroquinolones as Potential Candidates for New Antibacterial Agents Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Yildiz Uygun Cebeci, Sengul Alpay Karaoglu
: In this study, synthesis of 1,2,4 triazo1e-fluoroquino1one hybrid compounds was rea1ized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis confirmed the structures of a11 synthesized compounds. The antimicrobia1 activities of a11 compounds were investigated, and it
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Celecoxib Catalyzed the Coupling Reaction of Epoxide and CO2 Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Ling Wu, Xiaocheng Xia, Wenying An, Wenshan Cui, Yue Liu, Wei Lv, Fengtian Wu
: In this study, high yields of various cyclic carbonates were obtained by employing the drug celecoxib to promote the coupling reaction of CO2 and epoxide using tetrabutylammonium bromide. This strategy enabled the synthesis of benzoic acid, phenylpropiolic acid, and 2, 4- quinazolinedione. In addition, the model reaction mechanism was proposed. background: Cyclic carbonates have a high economic value
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Insight into the Various Approaches Undertaken for the Synthesis of Quinoline Hybrids Imparting Diverse Therapeutic Activities Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Ruchi Sharma, Chandana Majee, Rupa Mazumder, Avijit Mazumder, Swarupanjali Padhi, Akshay Kumar
: Quinoline is one of the promising and prominent biologically active N-based heterocyclic compounds. This review paper aims to discuss the synthetic approaches, summarized from various research articles on the preparation of quinoline derivatives intended for different therapeutic activities like antifungal activity, anticancer activity, anticonvulsant activity, antitubercular activity, antimalarial
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Synthesis of New Glucose-containing 5-Arylisoxazoles and their Enzyme Inhibitory Activity Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Roshanak Hariri, Aida Iraji, Somayeh Mojtabavi, Mina Saeedi, Mohammad Ali Faramarzi, Mohsen Amini, Tahmineh Akbarzadeh
: Carbohydrates are an important group of biomolecules that have received special attention due to their significant role in the design and synthesis of new bioactive compounds. In this study, a new class of 5-arylisoxazole-glucose hybrids was designed and synthesized for evaluation of their inhibitory effects on α-glucosidase, α-amylase, and tyrosinase. The target compounds depicted selective α-glucosidase
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Synthesis of N1-caffeoyl-N10-dihydrocaffeoylspermidine (Scotanamine D) Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Jingwen Ji, Zafar Iqbal, Liuyan Li, Jian Sun, Pengjuan Zhou, Lijuan Zhai, Lili He, Dong Tang, Jinbo Ji, Haikang Yang, Zhixiang Yang
: N1-caffeoyl-N10-dihydrocaffeoylspermidine (Scotanamine D), a spermidine alkaloid isolated from various plants, is a medicinally valuable natural product. Recent studies have pointed out several health benefits of this compound. However, its synthetic procedures are still not described in the literature. We report the synthesis of this compound following two different schemes comprising multiple steps
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Structure-based Drug Design of New Cinnamic Acid Derivatives as Tyrosinase Inhibitors Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Fayezeh Yousefnejad, Mohammad Hossein Sayahi, Ali Mazzam, Fatemeh Gholami, Nader Tanideh, Cambyz Irajie, Helia Tayebi, Fatemeh Rasekh, Bagher Larijani, Maliheh Barazandeh Tehrani, Mohammad Mahdavi, Aida Iraji
: Tyrosinase is a critical enzyme responsible for pigmentation disorders, and tyrosinase inhibition is an established strategy to treat hyperpigmentation. In the current study, cinnamic acidbased derivatives were designed and synthesized. All synthesized compounds were confirmed using IR, 1 HNMR, 13CNMR, and CNH analysis. The inhibitory potencies of all derivatives against tyrosinase were determined
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Nanostructured Iron (III)-Copper (II) Binary Oxide as a Highly Efficient Magnetically Recoverable Nanocatalyst for Facile One-pot Synthesis of 2, 4, 5-trisubstituted Imidazole and 1, 4-dihydro Pyridine Derivatives under Solvent-free Conditions Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Dhananjay N. Gaikwad, Suresh T. Gaikwad, Rajesh K. Manjul, Anjali S. Rajbhoj, Dayanand M. Suryavanshi
: The Fe (III)-Cu (II) binary oxide magnetic nanocatalyst emerges as an environmentally friendly and highly efficient solid acid catalyst, demonstrating remarkable utility in the one-pot synthesis of 2, 4, 5-trisubstituted imidazole and 1,4-dihydropyridine compounds, all achieved under solvent-free conditions. A facile co-precipitation method was used to synthesize nanostructured Fe-Cu binary oxide
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Malic Acid as a Green Catalyst for the N-Boc Protection under Solvent-free Condition Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-26 Ashok Pise, Shripad M Patil, Ajit P Ingale
: A protocol for the Chemoselective N-Boc protection of various types of amines has been developed. This includes heteroaryl, aliphatic, and alicyclic amines. The process makes use of malic acid as a catalyst and operates efficiently at ambient temperature without the need for solvents. This technique has been proven to effectively protect a wide range of functionalized amines containing both electron-donating
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Synthesis of Methyl N-phenylcarbamate Derivatives by Xphos Pd G2 Catalyzed Intermolecular Amidation Reaction Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-25 Yan-fen Shi, Zheng Wu, Jie Mou, Hong-hua Yuan
The utilization of palladium catalysts in cross-coupling reactions has emerged as a highly promising method for the facile formation of aryl C-N bonds, operating under mild conditions. In this study, we present an efficient approach for the synthesis of methyl N-phenyl carbamate derivatives through the intermolecular amidation of aryl chlorides, catalyzed by Xphos Pd G2. The developed protocol has
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Molecular Docking of Phytomolecules of Grain Amaranth (Amaranthus hypochondriacus) with AKR1C3 Protein Involved in Prostate Cancer in Human Beings Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-25 Dinesh Pandey, Manisha Bharti, Anubhav Rana, Sharat Prabhakaran, Rashmi Chauhan
aims: To know capability of phytomolecules (alpha-tocopherol, squalene, phytol) in grain Amaranth as drug candidate against AKR1C3 protein, responsible for prostate cancer. background: Amaranth is a pseudocereal, filled with medicinal properties, so for validation in initial stage, docking is cost effective and time saving approach with reliable outcomes. objective: Evaluation of grain Amaranth phytomolecules
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Atomic Electrostatic Potential as a Descriptor of Aminolysis of Phenyl and Thiophenyl Acetates and Hydrolysis of Acetanilides Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-25 Evgeny Krylov, Lyudmila Virzum, Matvey Gruzdev, Ulyana Chervonova
Hydrolysis of acetanilides and aminolysis of phenyl and thiophenyl acetates are related reactions since these are processes of nucleophilic substitution on the carbonyl carbon. Current views of chemical reactivity based on the DFT theory rely upon reactivity indices that are descriptors of both the reaction center and the molecule as a whole, and have not been applied to the given processes before
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Schiff Bases: Versatile Mediators of Medicinal and Multifunctional Advancements Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-23 Tanya Biswas, Ravi K. Mittal, Vikram Sharma, Kanupriya, Isha Mishra
This review aims to shed light on the profound implications of Schiff Bases in combating a spectrum of pathogens by delving into their complex classification, synthesis, and reactions. The investigation also covers the varied molecular properties of Schiff bases, highlighting their potential use as chelating agents in coordination chemistry. Moreover, the investigation explores the discerning nature
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Metal-Free Selective para-Tosyloxylation of N-Arylbenzamides using [Hydroxy( tosyloxy)iodo]benzene Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-23 Neha Rani, Deepak Kumar Aneja, Mayank Kinger, Rinku Soni, Monika Sihag, Sandeep Malik
An efficient approach for the tosyloxyl group transfer in several N-arylbenzamides has been achieved using HTIB (Koser’s reagent) under mild reaction conditions. Its simplicity, efficiency, and reduced reliance on hazardous reagents make it an attractive choice for chemists seeking sustainable alternatives. The proposed methodology offered single-step para-selective tosyloxylation, ensuring the prevention
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A Mild and Eco-friendly, One-pot Synthesis of 2-hydroxy-Narylacetamides from 2-chloro-N-arylacetamides Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-23 Vamshikrishna Y. Radhakrishna, Gopal L. Khatik, Bhuvaneshwari S. Vijaya, Vipin A. Nair
A mild and eco-friendly one-pot, two-step procedure has been developed for the synthesis of 2-hydroxy-N-arylacetamides from 2-chloro-N-arylacetamides. The procedure overcomes the cleavage of the amide linkage in 2-chloroacetamides, which is usually observed under reflux conditions with the hydroxide when the nucleophilic substitution of the halide is attempted. The reactions were performed by refluxing
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Towards Antiviral Potential of Biomolecules Derived from Adhatod avasica as Competent Natural Molecules to Treat COVID-19 Virus Variant Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-23 Mohammad Asif, Mohd Yusuf, Mazen Almehmadi, Ahad Amer Alsaiari, Mamdouh Allahyani, Abdulelah Aljuaid, Abdulaziz Alsharif
Adhatoda vasica (L.) (Acanthaceae) has essential therapeutic roles and is widely used in the indigenous medicine system or Ayurvedic system of medicine. The important goals of the present study are to report the in-silico anti-corona (COVID-19) activity of different phytochemicals present in A. vasica. This study will help to find specific bioactive compounds, and their use as anti- COVID-19 action
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A New Bioactive Thiazolidinone-based Azo Dye for Naked-eye Colorimetric Detection of Cyanide Ions Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-23 Zahra Zamiraei, Kurosh Rad-Moghadam
A new bioactive azo dye embedding a thiazolidinone heterocyclic core was designed and synthesized for antibacterial application and colorimetric sensing of cyanide ion (CNˉ) in organic solutions. The structure of the prepared dye was elucidated from its 1H NMR, FT-IR and UV-Vis spectral data. It proved to be a fast and sensitive colorogenic sensor for detection of CNˉ. Spectroscopic studies were carried
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A Comprehensive Review of the Benzimidazole Scaffold as a Potential Nucleus for Anti-Ulcer Activity Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-23 Kuldeep Singh, Bharat Bhushan, Ajit Kumar Varma, Ravi Shekhar, Rajeev Kumar Sharma, Niladry Sekhar Ghosh, Ekta Pandey, Sunam Saha, Shivendra Kumar, Avinash Kumar Mishra, Mohit Agrawal
The benzimidazole scaffold is a promising nucleus for developing novel therapeutic agents for ulcer treatment. Its unique chemical structure provides desirable pharmacological properties, such as excellent bioavailability, metabolic stability, and low toxicity, making it an attractive candidate for ulcer treatment. Several benzimidazole derivatives have shown significant anti-ulcer activity in preclinical
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An Efficient Propylphosphonic Anhydride (T3P®)-Mediated MW-induced Solvent-free Rapid Synthesis of Enamino Esters and Ketones including 5,5- Dimethyl-3-aminocyclohex-2-enones Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-23 Omid Marvi, Sattar Arshadi, Bita Baghernejad
This work presents a clean and convenient synthesis of various β-enaminones including 5,5- dimethyl-3-aminocyclohex-2-enones, in satisfactory to excellent yields from the condensation reaction of primary amines with β -dicarbonyls by employing T3P® as a catalyst and performing the reaction under microwave irradiation and solvent-free conditions. These rapid reactions launched readily and stood a diversity
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DFT Study of Nanotubes as the Drug Delivery Vehicles for an Anticancer Drug Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-23 Nasrin Masnabadi, Shiva Masoudi, Maryam Hosseinzadeh
:: Chemicals and poisons in the body interfere with the cell cycle and inhibit the growth of cancer cells. In this way, the function of chemicals in the body is controlled by taking anti-cancer drugs. Due to the degradability and compatibility of carbon nanotubes and boron nitride with the environment, they can act as suitable drug carriers for the transfer of anticancer drugs and deliver the drugs
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Synthesis, Characterization, and Optimization of Novel Furan-ring Fused Chalcones via Radical Cyclization of α,β-Unsaturated Ketones and Cyclic Ketone Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-22 Emine Vildan Burgaz, Bahareh Noshadi, Mehtap Yakut
Novel Furan-ring Fused Chalcones (FFC) were synthesized using a radical cyclization reaction of α,β-unsaturated ketones with cyclic ketone as the model reaction to attain this goal. In this study, traditional and microwave-assisted methods for the efficient and cost-effective synthesis of furan-ring fused chalcones in mild reaction conditions are compared and optimized. The goal is to develop a reliable
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Scalable, Chromatography-Free Synthesis of 1,7-dimethylxanthine Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-22 Shaoguang Sun, Yucheng Jiang, Hui Mao, Shuya Cui
1,7-dimethylxanthine is a critical intermediate in the pharmaceutical industry. In this paper, a scalable route for the synthesis of 1,7-dimethylxanthine was developed. The method included two steps: (1) acylation reaction of ethyl 4-amino-1-methyl-1H-imidazole-5- carboxylate was carried out by using commercially available methylcarbamoyl chloride as the starting material; (2) through cyclization of
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A Green and Convenient Approach for the Synthesis of Indole-acrylonitrile and Indole-coumarin Hybrids in Aqueous Media Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-22 Adeleh Moshtaghi Zonouz, Davoud Moghani
Indole–acrylonitrile hybrids were synthesized via a catalyst-free reaction of aromatic aldehydes and 3-(cyanoacetyl)indole in aqueous media. Also, indole-coumarin hybrids were synthesized via a domino reaction of salicylaldehyde derivatives and 3-(cyanoacetyl)indole in the presence of ammonium acetate in aqueous media. The advantages of the present protocol are high yields, short reaction times, mild
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Synthesis and Development of a Nonaflate Ester in the Large-Scale Preparation of 3-Deoxymorphine Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-22 Antonio M. Ruda, Jonathan D. Moseley
: A series of novel activated esters of morphine were synthesized as alternatives to the triflate ester and submitted to hydrogenolysis conditions. Of these, only the novel nonaflate ester could be transformed with full conversion into the useful intermediate, 3-deoxymorphine, which was isolated in good yield and high purity without chromatography. This conversion proceeded significantly faster than
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Density Functional Theory Study of Interaction between Ibuprofen and Alginic Acid for Targeted Drug Delivery Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-21 Masoumeh Shahi, Donya Falahati, Fatemeh Ashtari
: The development of density functional theory has led to the consideration of computational chemistry in the design and development of interactions of new drugs in the gas phase with nanocarriers. In the present study, the interaction of ibuprofen with alginic acid (as a nanocarrier) has been investigated using density functional theory (DFT) in the gas phase (M06-2X/6-31+G*). A study on the effects
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Optimization and Effect of Substituents on the Transformation of 3-(Substituted acetoxy)azetidin-2-ones to Chiral 3-Hydroxyazetidin-2-ones, Molecular Docking and Enantiomeric Excess Determination Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-19 Aman Bhalla, Garima Modi, Pankaj Kumar, Jaswinder Kaur, Shiwani Berry, S.S. Bari, Bimal K. Banik
The enantioselective synthesis of chiral cis-3-hydroxyazetidin-2-ones mediated by Porcine Pancreatic Lipase (PPL) via hydrolysis of cis-3-(chloro acetoxy) azetidin-2-ones in the presence of a phosphate buffer (0.1M, pH = 7.2) in acetonitrile at a temperature range of 25-35 °C was optimized. Under the optimized reaction conditions, the influence of various electron withdrawing/donating/neutral groups
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Harnessing Computational Modeling for Efficient Drug Design Strategies Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-16 Kuldeep Singh, Bharat Bhushan, Akhalesh Kumar Dube, Anit Kumar Jha, Ketki Rani, Akhilesh Kumar Mishra, Prateek Porwal
Computational modeling has become a crucial tool in drug design, offering efficiency and cost-effectiveness. This paper discusses the various computational modeling techniques used in drug design and their role in enabling efficient drug discovery strategies. Molecular docking predicts the binding affinity of a small molecule to a target protein, allowing the researchers to identify potential lead
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Study on the Reactivity of Mixed Carboxylic Palmitic Anhydrides via the Esterification Reaction Using Heterogeneous Catalyst Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-12 Marwa Derbel, Iteb Trabelsi, Kamel Essid
: Lipid esters are prepared from mixed fatty anhydrides by esterification. These esters are high-value-added intermediates used in industrial applications. We describe the synthesis and characterization of esters using salicylic acid and mixed anhydrides with zinc oxide as catalysts. To achieve maximum reaction efficiency, we varied the mixed anhydride and studied some parameters in the reaction, such
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Can Glycerol Carbonate be Synthesized Without a Catalyst? Lett. Org. Chem. (IF 0.8) Pub Date : 2024-01-12 Sanjib Kumar Karmee
: Biodiesel and oleo-chemical industries have been producing huge quantities of glycerol as a by-product. Value-added products can be synthesized from glycerol through different chemical and enzymatic reactions, such as oxidation, carbonylation, reforming, acetalyzation, etherification, dehydration, hydrogenolysis, hydrolysis, esterification, and transesterification. Glycerol is a low-cost polyol that
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1,3,4-Thiadiazole: A Versatile Scaffold for Drug Discovery Lett. Org. Chem. (IF 0.8) Pub Date : 2023-12-22 Ravi K. Mittal, Raghav Mishra, Vikram Sharma, Isha Mishra
1,3,4-Thiadiazole has garnered considerable attention in the scientific community due to its captivating molecular structure and ability to serve as a foundation for creating novel pharmaceutical compounds. Numerous medications feature the 1,3,4-thiadiazole ring in their chemical structure, highlighting its relevance and efficacy in pharmaceutical research and development. The key objective of this
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Phytochemical Evaluation of Selected Ayurvedic Formulations and Evaluate their Antioxidant Activity Lett. Org. Chem. (IF 0.8) Pub Date : 2023-11-27 Awadhesh Kumar, Akash Ved, Karuna S. shukla, Amit Kumar Nigam
The Ayurvedic formulations' evaluation is very wide and deep. The project's goal was to evaluate the phytochemistry and antioxidant activity of Ayurvedic formulations used to treat digestive disorders. Herbal formulations are typically available as single or mixed formulations of multiple plant constituents, and it is critical to quantify the number of markers present in such formulations to ensure
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Study of Structural Elucidation, Degradation Kinetics and Antimicrobial Analysis of Copper (II) Sesame-Soap Complexes with Urea and Thiourea Ligand in Non-aqueous Solvents Lett. Org. Chem. (IF 0.8) Pub Date : 2023-11-20 Asha Meena
Surfactants have great importance in biological and drug industries and the complexes of metallic soaps with various ligands are used in approximately every region of national economy. Therefore, our keen interest to study of degradation kinetics and biological importance of Cu (II) surfactants in non-aqueous and non-polar solvent benzene. Present research work has been initiated with synthesis, systematic
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A Novel Study on Antioxidant Activity and Catalytic Reduction of Methylene Blue using ZnO Nanoparticles Synthesized via the Middle Part of Walnut Shell (Juglans regia) Extract Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-30 Pouya Jafari, Mohammad Hadi Meshkatalsadat, Behjat Pouramiri
The synthesized ZnO nanoparticles were characterized using UV-Vis spectroscopy, SEM, XRD, FTIR, and TEM analysis. The catalytic activity of the prepared green catalyst ZnO nanoparticles was also investigated in the dye methylene blue (MB) decomposition. The catalytic decomposition reaction completed within 20 minutes, demonstrating the excellent catalytic properties of ZnO nanoparticles in reducing
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N-acetylation of Aromatic Amines by One-pot Route Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-26 Zhongqi Guo, Wenxu Fan, Keyume Ablajan
In this study, a simple one-pot synthesis of acetamides from aromatic amines and acetonitrile in the presence of H2O and K2S2O8 is presented. The reaction proceeds in a mixed solvent (CH3CN: DMSO, 3:1) without using metals or toxic reagents. Various N-acetanilides are obtained with 53-91% yields. The method is selective for aromatic amines, with aliphatic amines remaining intact. This represents a
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A Convenient Synthesis of Bis-(dihydro)caffeoylspermidines Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-24 Lili He, Jian Sun, Pengjuan Zhou, Jingwen Ji, Lijuan Zhai, Dong Tang, Jinbo Ji, Haikang Yang, Zafar Iqbal, Zhixiang Yang
Caffeoyl spermidines are valuable alkaloids naturally existing in many plant species. These alkaloids are characterized as pharmacologically important ingredients of many plant extracts used in traditional medicines. Bis-caffeoylspermidine and bis-dihydrocaffeoylspermidine exhibit antioxidant, anti-inflammatory, and enzyme inhibition properties that make them valuable natural sources of safer therapeutic
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Synthesis, Bioactivity Evaluation, and Molecular Docking Study of Tranilast Analogs as Anticancer Agents Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-20 Phuong-Thuy T. Phan, Tuan-Anh N. Pham, Ngoc Phuong Nguyen, Van-Anh Tran Nguyen, Tuyet Hong Nguyen
Developing new agents with higher therapeutic potential and less toxicity to overcome the limitations of chemotherapy in cancer treatment has been identified as an urgent need and priority. Recent studies have shown promising anticancer activities of tranilast when used alone or in combination with other chemotherapeutic agents. This research aims to synthesize tranilast analogs, evaluate in vitro
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Silica-supported Active Ni Nanocatalyst for Wittig Reaction Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-13 Vivek Srivastava
The preparation and characterization of SBA-15 supported Ni catalysts with varying metal loading (1, 2, and 3% by weight) was carried out using the impregnation technique, followed by a rigorous characterization using advanced analytical techniques. The catalytic performance of the synthesized catalysts was evaluated for the Wittig-type olefination reaction, and it was found that the SBA- 15-3Ni catalyst
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In-silico Identification of Dexamethasone-similar Compounds Against SARS-Cov-2 Spike Protein: A Drug Repurposing Approach Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-12 Yamini Pathak, Vishwas Tripathi, Ihosvany Camps, Faizan Abul Qais, Amaresh Mishra
To identify potential drug candidates for the treatment of COVID-19 using a computational method. The recent pandemic of COVID-19 is observed as not less than a natural calamity of humankind and raised serious concerns for its immediate management. The continued spread of coronavirus disease across the globe poses a significant threat to human health. Out of this, the application of Dexamethasone has
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Isatin Derivatives: A Frontier in Antimicrobial Agents Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-10 Shareef Shaik, Manish Chaudhary, Charanjit Kaur, Rajesh Kumar, Gurvinder Singh
Microbial infection is one of the major concerns for human health in the modern era. Condition is further worsening due to the development of resistance by the microbe against the available drugs. This problem can be overcome by synthesizing novel antimicrobial agents. Isatin is a promising moiety possessing antimicrobial activity. A number of isatin derivatives are present in the market for the treatment
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Study of Interactions of Nucleoside Anticancer Drugs, Capecitabine and Gemcitabine, with SWNT and BNNT using Molecular and Quantum Mechanical Calculations Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-10 Fatemeh Moosavi, Neda Hasanzadeh, Hooriye Yahyaei, Aye Rayatzadeh
Using single-wall carbon nanotubes (SWCNTs) and boron nitride nanotubes (BNNTs), this study evaluated the interactions between Capecitabine (CAP) and Gemcitabine (GEM). Molecular mechanics and quantum mechanics were used in the analysis. The interaction between CP and GM with SWCNTs and BNNTs under various solvents was analyzed using the self-consistent reaction field (SCRF) as a model and DFT as the
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Facile Synthesis of Electron-deficient Epoxides Adjacent to Ester and Cyanide Groups Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-10 Sujata V. Bhat, Mayur Uttekar, Manisha O. Gupta
The addition of camphor and oxone® during the epoxidation led to the synthesis of seven novel epoxides. Since the tri-substituted double bond of -cyano-cinnamates has been epoxidized, the reaction is easier to carry out and cleaner, producing a high yield of epoxides. Several molecules with industrial applications will result from the selective ring opening of epoxides.
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A Review on Diverse Biological Activity of Heterocyclic Nucleus Pyrazine and its Derivatives: A Key for the Researchers Lett. Org. Chem. (IF 0.8) Pub Date : 2023-10-09 Shilpi Pathak, Neetu Agrawal, Sonam Gaur
Pyrazine belongs to the 1, 4-diazines family, which is a significant class of heterocyclic compounds. Various pyrazine derivatives have been produced and successfully confirmed as medicines with various pharmacological activities like anti-inflammatory, antitubercular, anticancer, antibacterial, and neurological activity, with some of them becoming clinically utilized pharmaceuticals globally. This