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Photo-Induced α-Oxyalkylation of Aryl Chlorides with Ethers and Alcohols through Homolytic Aromatic Substitution Synthesis (IF 2.6) Pub Date : 2024-03-12 Kohei Aoki, Kyohei Yonekura, Wataru Ejima, Shota Tanaka, Ami Shigeta, Eiji Shirakawa
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Transition-Metal-Catalyzed C–H Activation Reactions for the Creation and Modification of Organic Fluorophores Synthesis (IF 2.6) Pub Date : 2024-03-11 Tapasi Chand, Manmohan Kapur
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LemPhos – New P-Chiral Phospholene Core Based Ligand Synthesis (IF 2.6) Pub Date : 2024-03-07 Adam Włodarczyk, Łukasz Ponikiewski
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Catalytic Asymmetric Synthesis of α-Mono and α,α-Disubstituted 5- and 6-Membered α-Aza-lactams Synthesis (IF 2.6) Pub Date : 2024-03-06 Claudio Palomo, Aitor Landa, Mikel Oiarbide
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Friedel–Crafts Alkylation of Indoles with Aldehydes/Ketones Catalyzed by Bromodiarylethene-Based Photoacid Generators Synthesis (IF 2.6) Pub Date : 2024-03-06 Alexey V. Zakharov, Sofia M. Timofeeva, Valerii Z. Shirinian
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Synthesis of Acyl Hydrazides and Hydrazones from Activated Amides Synthesis (IF 2.6) Pub Date : 2024-03-06
Acyl hydrazide and acyl hydrazone synthesis methods were developed. They involve the reaction of an activated amide with hydrazine under transition-metal-catalyst-free conditions. Additionally, acyl hydrazones were synthesized by extending the same reaction procedure in the presence of aldehydes (or ketones). These reactions were performed in an aqueous environment at 25 °C, demonstrating the successful
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Asymmetric Allylic Substitution Reactions Based on Relay Catalysis Synthesis (IF 2.6) Pub Date : 2024-03-05 Zhenwei Wu, Xiaoming Feng, Yangbin Liu
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Synthesis of Phosphinoboranes via Coordination-Induced Bromine Abstraction of an Isolable Phosphinyl Radical with Bromoboranes Synthesis (IF 2.6) Pub Date : 2024-03-01 Shintaro Ishida, Yasuhiro Katayama, Fumiya Hirakawa, Takeaki Iwamoto
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Heptafluorobutyric Acid Catalyzed Cross-Dehydrogenative Coupling of 7-Aminocoumarins with 1,2,4-Triazines: A Straightforward Pathway to 3-Triazinyl-7-aminocoumarins Synthesis (IF 2.6) Pub Date : 2024-03-01 Ramil F. Fatykhov, Igor A. Khalymbadzha, Ainur D. Sharapov, Anastasia P. Potapova, Anton N. Tsmokalyuk, Vasiliy S. Gaviko
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Synthesis of the Cyclohexane Fragment Peculiar to Enacyloxins: Study of Its Assembly and Protective Groups Removal Synthesis (IF 2.6) Pub Date : 2024-03-01
The enantioselective synthesis of the protected (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylic acid moiety shared among all members of the enacyloxin family has been successfully accomplished. Having obtained this fragment, we devised assembly conditions using models that mimic the enacyloxin acyl chain. Additionally, we assessed conditions for the removal of protective groups, aiming to avoid previously
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Preparations of Silyl Anions Synthesis (IF 2.6) Pub Date : 2024-02-29 Feba T. Pulikkottil, Venkadesh Balakrishnan, Revathi Chandrasekaran, Vetrivelan Murugesan, Ramesh Rasappan
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Phosphazene-Catalyzed Regioselective Condensation of Allyl Thioethers with Aldehydes: A Rapid Approach to 1,3-Dienyl Sulfides, -Sulfoxides and -Sulfones Synthesis (IF 2.6) Pub Date : 2024-02-27 Supasorn Phae-nok, Chutima Kuhakarn, Pawaret Leowanawat, Vichai Reutrakul, Darunee Soorukram
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A Simple and Efficient Approach for the Synthesis of Aryl-3-(trifluoromethyl)-1H-1,2,4-triazol-5(4H)-one Derivatives Synthesis (IF 2.6) Pub Date : 2024-02-27 Elham Kazemi, Najmeh Zeinali, Ali Darehkordi
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Stereochemical Aspects of the C-Glycosylation of Pyranosides and Furanosides Synthesis (IF 2.6) Pub Date : 2024-02-26 Srinivas Achanta, Ch. V. A. Sasikala, Debjit Basu, Pradip D. Nahide, Rakeshwar Bandichhor
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Visible-Light-Driven Oxidative Chlorination of Alkyl sp3 C–H Bonds with HCl/Air at Room Temperature Synthesis (IF 2.6) Pub Date : 2024-02-26
An aerobic chlorination of alkyl sp3 C–H bonds of functionalized alkanes and simple alkanes has been established successfully under visible light at room temperature. The reaction is performed in the presence of catalytic NaNO2 using HCl or NaCl/acid as a chlorine source and air as a terminal oxidant under atmospheric pressure. It is suggested that NOCl from NaNO2/HCl is a crucial species in the catalytic
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Synthesis of Anti-oxidant Steroids by Hybridisation with Nitroxides Synthesis (IF 2.6) Pub Date : 2024-02-26 Carl P. Soltau, Naomi E. Weir, Alexander P. Martyn, Steven E. Bottle
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Generation of Alkylidene Carbenes through Tetrazole Fragmentation: Recent Advances and Applications in Organic Synthesis Synthesis (IF 2.6) Pub Date : 2024-02-22 Shinya Harusawa, Hiroki Yoneyama, Yoshihide Usami
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Hypervalent Iodine Mediated Synthesis of Thiosulfonates from Sulfonyl Hydrazides and Their Transformation into Symmetrical Disulfides Synthesis (IF 2.6) Pub Date : 2024-02-22 Ashvani Yadav, Rohit Kumar, Virendra Prasad
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Iron-Catalyzed [2+1+2+1] Annulation of Amines and N,N-Dimethyl Enaminones using N,N-Dimethylaminoethanol as a One-Carbon Synthon for the Synthesis of 1,4-Dihydropyridines Synthesis (IF 2.6) Pub Date : 2024-02-22
A simple and efficient method for the synthesis of 1,4-dihydropyridines from amines, N,N-dimethyl enaminone and N,N-dimethylaminoethanol in a four-component [2+1+2+1] annulation catalyzed by FeCl3 has been established, where N,N-dimethylaminoethanol was applied as a methine source. The procedure was executed smoothly, resulting in the synthesis of a wide range of 1,4-dihydropyridines with moderate
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Synthesis, Photophysical, and AIE Properties of 2H-Imidazole-Derived Push-Pull Fluorophores Synthesis (IF 2.6) Pub Date : 2024-02-22
A four-stage method for the synthesis of 2H-imidazole-derived push-pull fluorophores was developed. The synthesized compounds are characterized by absorption in the range of 250–400 nm, emission of up to 617 nm, and quantum yields of up to 99%. Compounds bearing a tetraphenylethylene fragment demonstrated the AIE effect in a solution with a water fraction fw >90% and significant increase in the emission
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Synthesis of Alkyl Thiochromano[2,3-c]pyrrole-9-carboxylate Derivatives Utilizing Benzo[b]thiofuran-2,3-dione, Maleimides, and Alkyl Alcohol/Water Mixtures Synthesis (IF 2.6) Pub Date : 2024-02-22 Mohammed M. Abadleh, Jalal A. Zahra, Salim S. Sabri, Rania R. Abuzaid, Dieter Schollmeyer, Mustafa M. El-Abadelah
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Synthesis of (5-Iminio-4,5-dihydro-1,3,4-oxadiazol-2-yl)tetrazol-1-ide: A Zwitterionic Compound Containing a Tetrazole Anion as a Promising Blunt Energetic Material Synthesis (IF 2.6) Pub Date : 2024-02-21 Yaxin Liu, Meifang Lv, Guofeng Zhang, Zhiwen Ye
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A Convenient Method for Synthesizing 1-Alkyl-2-acyl-sn-glycero-3-phosphoethanolamines Synthesis (IF 2.6) Pub Date : 2024-02-20 Tatsuo Okauchi, Kouta Tsubaki, Yuri Higuma, Hirokazu Shimooka, Mitsuru Kitamura
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Metal-Free Synthesis of Trifluoromethyl Carbinol-Containing Imidazo[1,2-a]pyridines via Dehydrative Coupling of Imidazo[1,2-a]pyridines with Trifluoroacetaldehyde Synthesis (IF 2.6) Pub Date : 2024-02-20 Zhaowen Liu, Xiaohua Guo, Zhixi Chen, Longhui Wu, Kai Yang
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Product Selectivity Control under Acidic and Basic Conditions on Oxidative Transformation of 1,3-Dicarbonyls Using Sodium Hypochlorite Pentahydrate Synthesis (IF 2.6) Pub Date : 2024-02-20 Masayuki Kirihara, Yugo Sakamoto, Takumi Tanaka, Takuma Kawai, Tomohide Okada, Yoshikazu Kimura, Shinobu Takizawa
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Divergent Reactivity of δ-Acetoxy Allenoates with 1,3-Bisnucleophiles: Synthesis of Multisubstituted Pyran, Dihydropyran, and 3-Vinylpent-2-enedioate Scaffolds Synthesis (IF 2.6) Pub Date : 2024-02-20 Shabbir Ahmed Khan, K. C. Kumara Swamy
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Unveiling Novel Synthetic Pathways through Brook Rearrangement Synthesis (IF 2.6) Pub Date : 2024-02-19
The Brook rearrangement is a valuable synthetic tool that facilitates the controlled construction of complex molecules. Conventionally, it generates carbanion intermediates utilized in subsequent functionalization reactions. In this review, we will explore recent advancements in the Brook rearrangement that extend beyond the traditional functionalization reactions. Specifically, we will highlight its
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Access to 8-Aminoindolizine Fused with Quinone via Cu(OAc)2-Catalyzed Domino [4+2] Annulation Synthesis (IF 2.6) Pub Date : 2024-02-19
Cu(OAc)2-catalyzed [4+2] annulation of N-substituted pyrrole-2-carbonitriles with quinones allowed access to a wide range of 8-aminoindolizines fused with quinones through a domino process involving a sequence of intermolecular Michael addition, Thorpe–Ziegler type cyclization, and aromatization. Biological evaluation of the resulting quinone-8-aminoindolizine hybrids revealed significant anticancer
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Exploring the Reactivity of Substituted [(Allyloxy)methyl]phosphonates in Cycloaddition and Coupling Reactions Synthesis (IF 2.6) Pub Date : 2024-02-15 Momtez Jmai, Virginie Blot, Monique Mathé-Allainmat, Mohamed Lotfi Efrit, Didier Dubreuil, Hédi M’rabet, Jacques Lebreton
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Convenient Synthesis of Hexa- and Pentasaccharide Repeating Units Corresponding to the O-Polysaccharides of Acinetobacter baumannii O7 and Acinetobacter baumannii O10 Strains Synthesis (IF 2.6) Pub Date : 2024-02-14
The synthesis of the hexa- and pentasaccharide repeating units of the cell wall O-polysaccharides of Acinetobacter baumannii O7 and O10 strains, respectively, has been achieved in very good yield using [4+2] and [4+1] block glycosylation strategies. The p-methoxybenzyl (PMB) group was used as an in situ removable protecting group, which was removed after glycosylation in the same pot by tuning the
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Nicholas Reactions of Pentadiynyl–Co2(CO)6 Cations. Synthesis of Antimalarial Hinokiresinol Analogues Synthesis (IF 2.6) Pub Date : 2024-02-14 Marcus Muresan, James R. Green
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I2-Catalyzed Oxidative Acylation of Tertiary Amines via C–N Bond Cleavage Synthesis (IF 2.6) Pub Date : 2024-02-14 Xin Ge, Ping Lei, Qin Su, Ying-Ming Pan, Keyume Ablajan
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Zinc/Bismuth-Mediated Allylation Reaction of Biomass Feedstocks: Synthesis of Furanic Diols Synthesis (IF 2.6) Pub Date : 2024-02-14
Biomass-based diols have been synthesized by a Zn/Bi-mediated Barbier-type of reaction from furanic aldehydes and allyl halides to access allylated diols. The allylated diols can be readily converted into alkylated diols by hydrogenation. These furanic diols could be potential replacements for fossil fuel based bisphenol A (BPA) which has an adverse endocrine-disrupting effect on humans. This mild
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Stereoselective Synthesis of 3,4-Dihydrobenzofuro[3,2-b]pyridin-2(1H)-ones Enabled by Pd/Chiral Isothiourea Relay Catalysis Synthesis (IF 2.6) Pub Date : 2024-02-13 Mostafa Sayed, Zhipeng Shi, Tao Fan, Hong-Cheng Shen, Zhi-Yong Han
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K2CO3-Mediated Intramolecular Oxa-Michael Cyclization of α,β-Unsaturated Ketoximes: Synthesis of Densely Arene-Substituted 2-Isoxazolines Bearing a Quaternary Center Synthesis (IF 2.6) Pub Date : 2024-02-13
An efficient K2CO3-mediated intramolecular oxa-Michael cyclization of β,β-diarylated α,β-unsaturated ketoximes is described. This methodology allows access to arene-rich 2-isoxazoline derivatives bearing a quaternary center in excellent yields with an operationally simple experimental procedure. Deuterium-scrambling experiments were carried out to shed light on the reaction pathway. To demonstrate
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Efficient Synthesis of (2Z,5Z)-3-Benzyl/alkyl-5-(2-oxo-5-aryl-3 (2H)-furanylidene)-2-(phenylimino)-1,3-thiazolidin-4-ones via a One-Pot Three-Component Reaction Synthesis (IF 2.6) Pub Date : 2024-02-13 Abdolali Alizadeh, Reihaneh Moterassed
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Total Synthesis of Daphniphyllum Alkaloids: (+)-Daphlongamine E, (+)-Calyciphylline R, and (–)-10-Deoxydaphnipaxianine A Synthesis (IF 2.6) Pub Date : 2024-02-13 Yan Zhang, Yuye Chen, Jing Xu
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Revolutionizing C–H Activation Reactions: Harnessing Green Solvents for Sustainable Catalysis Synthesis (IF 2.6) Pub Date : 2024-02-12 Dewal Deshmukh, Nikunjkumar Vagadiya, Samadhan Jagtap, Pravin Malasane
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Rapid Access to cis-1,3-Dialkylindanes: Asymmetric Formal Syntheses of epi-Mutisianthol and epi-Jungianol Synthesis (IF 2.6) Pub Date : 2024-02-12 Cong So Tran, Moonsang Yoon, Long Duc Le, Seoyeong Kim, Huiae Kim, Jisu Kim, Long Huu Nguyen, Minseob Koh, Hwayoung Yun
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Solvent-Free Efficient Synthesis of New 4-Thiazolidinones with a Fructose Scaffold through a Microwave-Assisted Cascade Multicomponent Reaction Synthesis (IF 2.6) Pub Date : 2024-02-12
Using a chemoselective, sustainable and highly efficient method, new 4-thiazolidinones and 1,4-thiazepan-3-ones substituted with a glycosidic residue derived from d-fructose were synthesized. Microwave-assisted cascade multicomponent reaction under solvent-free conditions gave very good yields in short reaction times, which was followed by a nontoxic purification method of one of the diastereomers
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Iodine-Promoted Disproportionate Coupling Reaction of Arylsulfonyl Hydrazides: A Simple and Green Access to Thiosulfonates Synthesis (IF 2.6) Pub Date : 2024-02-12 Qi Chen, Zhao-Hua Chen, Yong-Tong Liang, Yong Zeng, Shi-Wei Yu, Kai Yang, Zhao-Yang Wang
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Synthesis of Thiazole-fused Tricyclic Quinazolinone Alkaloids and Their Derivatives Synthesis (IF 2.6) Pub Date : 2024-02-12 Nathan Broudic, Corentin Layec, Corinne Fruit, Thierry Besson
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Tertiary Amines as Temporary Masked Secondary Amines: A Direct Access to 5-Dialkylamino-1,2,4-oxadiazoles from 1,2,4-Oxadiazol-5(4H)-ones Synthesis (IF 2.6) Pub Date : 2024-02-12 Muh Alfliadhi, Mookda Pattarawarapan, Surat Hongsibsong, Nittaya Wiriya, Wong Phakhodee
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Organocatalytic Atroposelective Reactions of Alkynes Synthesis (IF 2.6) Pub Date : 2024-02-08
The atroposelective transformation of alkynes is an efficient protocol for the assembly of axially chiral compounds. Benefitting from the rapid development of chiral organocatalysts, the organocatalytic atroposelective reactions of alkynes have been extensively studied over the past decades. An array of chiral catalysts, including chiral Brønsted acid catalysts, secondary amine catalysts, N-heterocyclic
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Copper-Catalyzed Enantioselective Radical Esterification of Propargylic C–H Bonds Synthesis (IF 2.6) Pub Date : 2024-02-08 Jiajia Xi, Xiaotao Zhu, Hongli Bao
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Synthesis of Amides and Peptides by Employing [4-(Acetylamino) phenyl]imidodisulfuryl Difluoride (AISF) as a Coupling Reagent Synthesis (IF 2.6) Pub Date : 2024-02-08 Swetha Bharamawadeyar, Eti Chetankumar, Chinthaginjala Srinivasulu, Vommina V. Sureshbabu
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An Improved and Scalable Synthesis of the Potent SREBP Inhibitor KK-052 via [3+2] Cycloaddition Synthesis (IF 2.6) Pub Date : 2024-02-07 Fumihiro Kawagoe, Sayuri Mototani, Yasushi Takemoto, Motonari Uesugi, Atsushi Kittaka
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Metal-Free N-Formylation of Amines Using Carbohydrates as C1 Synthon via C–C Bond Cleavage Synthesis (IF 2.6) Pub Date : 2024-02-07 Shital Atpadkar, Manjinder Singh Gill
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LiO-t-Bu/CsF-Mediated Formal Hydrolysis of Trifluoromethyl Arenes Synthesis (IF 2.6) Pub Date : 2024-02-01 Masanori Shigeno, Moe Kiriyama, Koki Izumi, Keita Sasaki, Ozora Sasamoto, Kanako Nozawa-Kumada, Yoshinori Kondo
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Organocatalytic Approach to the Enantioselective Total Synthesis of (+)-Serinolamides A and B and (+)-Lacosamide Synthesis (IF 2.6) Pub Date : 2024-01-31 Amardeep R. Jadhao, Suresh B. Waghmode
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Alumina-Promoted Copper-Catalyzed Hydroboration of Alkynes Synthesis (IF 2.6) Pub Date : 2024-01-31 Xenia A. Barashkova, Mikhail J. Parulava, Yury N. Kotovshchikov, Gennadij V. Latyshev, Nikolay V. Lukashev, Irina P. Beletskaya
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Stereodivergent Carbon–Carbon Bond-Forming Reactions Synthesis (IF 2.6) Pub Date : 2024-01-29 Alan R. Healy
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Photocatalyzed C–F Bond Heteroarylation of Trifluoromethylarenes with Heteroarenes: Two Roles of Bu3SnI as Fluoride Ion Scavenger and Activator for Photocatalyst Synthesis (IF 2.6) Pub Date : 2024-01-29 Naoki Sugihara, Masayuki Abe, Yoshihiro Nishimoto, Makoto Yasuda
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Short Synthesis of Dopamine Agonist Rotigotine Synthesis (IF 2.6) Pub Date : 2024-01-29
A practical and short synthesis of FDA approved drug, Rotigotine, is achieved in two steps from 5-methoxy-2-tetralone, which in turn was synthesised by [4+2] cycloaddition of the in situ generated methoxyaryne from its precursor aryl triflate with benzyloxybutadiene or from 4-methoxyindanone via ring expansion using trimethylsilyldiazomethane.
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Recent Developments on the Earth-Abundant-Metal-Catalyzed α,β-Dehydrogenation of Carbonyl Compounds Synthesis (IF 2.6) Pub Date : 2024-01-25 Peng-Fei Dai, Qiang-Qiang Li, Jian-Ping Qu, Yan-Biao Kang
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Atroposelective Construction of Tetrasubstituted Axially Chiral Alkene Frameworks Synthesis (IF 2.6) Pub Date : 2024-01-24 Jia-Yu Zou, Wan-Yi Xu, Jie Wang, Qi Liu, Ying He
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Mechanism of the Mitsunobu Reaction: An Ongoing Mystery Synthesis (IF 2.6) Pub Date : 2024-01-24 Elizabeth A. Croll, Ohyun Kwon
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DBU-Mediated Oxidation of β-Dicarbonyls: Formation of Hydroxylated and Rearranged Products under Air Atmosphere Synthesis (IF 2.6) Pub Date : 2024-01-24 Shuai Peng, Tianqi Wang, Xixuan Zhao, Boan Yao, Kaishuo Zhao, Yongguo Liu, Baoguo Sun, Hongyu Tian, Sen Liang
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Efficient Synthesis of Pyrido[3,4-c]cinnolines and Pyrido[3,2-c]cinnolines by Intramolecular Azo Coupling Reaction of 4,6-Diaryl-3-pyridine Diazonium Salts and Study of Their Antiviral Activity Synthesis (IF 2.6) Pub Date : 2024-01-24 Alina Yu. Fisenko, Vladislav Yu. Shuvalov, Evgenii V. Arshinov, Larisa V. Glizdinskaya, Larisa N. Shishkina, Nikolay I. Bormotov, Olga A. Serova, Galina P. Sagitullina