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The Protective Effects of Orthosiphon stamineus Extract Against Intestinal Barrier Injury in High-Fat Diet-Induced Mouse and Oxidative Stress Cell Models Nat. Prod. Commun. (IF 0.468) Pub Date : 2021-01-12 Xuan Cai; Lihui Zhu; Xiaofeng Yin; Huiqin Xue; Changfeng Xiao; Yiqiong Hang; Jianxiong Xu; Yonghong Lu
Orthosiphon stamineus Benth. (Lamiaceae) is commonly used for the treatment of kidney diseases, but its role in intestinal barrier function remains unknown. The present study investigated the protective effects of O. stamineus extract (OE) against oxidative stress-induced injury to the small intestinal epithelium and the possible mechanism. High-performance liquid chromatography fingerprinting was
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Polygokingiasides A and B: Two New Spirostane Glycosides From the Roots of Polygonatum kingianum With Nitric Oxide Inhibitory Activity Nat. Prod. Commun. (IF 0.468) Pub Date : 2021-01-12 Tran Thi Thu Ha; Trinh Quang Huy; Pham The Chinh; Phan Van Kiem
Two new spirostane glycosides, named polygokingiaside A (1) and polygokingiaside B (2), and 6 known spirostane glycosides, (25R)-26-O-(β-d-glucopyranosyl)-furost-5-en-3β,22α,26-triol 3-O-β-d-glucopyranosyl-(1→4)-β-d-galactopyranoside (3), (25S)-26-O-(β-d-glucopyranosyl)-furost-5-en-3β,22α,26-triol 3-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl-(1→4)-β-d-galactopyranoside (4), (25R)-26-O-(β-d-gluc
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Chemical Composition, Antimicrobial, and Cytotoxic Activities of Leaf, Fruit, and Branch Essential Oils Obtained From Zanthoxylum nitidum Grown in Vietnam Nat. Prod. Commun. (IF 0.468) Pub Date : 2021-01-12 Tran Thi Tuyen; Pham Minh Quan; Vu Thi Thu Le; Tran Quoc Toan; Do Huu Nghi; Pham Cao Bach; Cam Thi Inh; Nguyen Phuong Hanh; Trinh Anh Vien; Pham Thi Hong Minh; Pham Quoc Long; Nguyen Hong Khoi Nguyen; Pham Nguyen Thuy Dung; Nguyen Thi Hong Van
Zanthoxylum nitidum (Roxb.) DC is a traditional Vietnamese medicine to treat coughs, stomachache, toothache, blood stagnation, and sore throats. The essential oils (EOs) of the leaves, fruits, and stems of this plant were extracted by hydrodistillation and subjected to analysis by gas chromatography (GC)-flame ionization detector (FID) and GC-mass spectrometry (MS). The isolated EOs were then evaluated
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Bioactive Polyketides From the Potato Endophytic Fungus Aspergillus carneus Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-29 Xian Zhang; Fa-Lei Zhang; Xing Wu; Ke Ye; Xiao Lv; Hong-Lian Ai; Ji-Kai Liu
A previously undescribed polyketide (1) and 3 known analogs (2-4) were obtained from cultures of the potato endophytic fungus Aspergillus carneus. The structures were elucidated on the basis of extensive nuclear magnetic resonance spectroscopic data. The absolute configuration of 1 was further determined by electronic circular dichroism and optical rotation calculations. Compounds 1-4 showed moderate
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Compounds Isolated From the Fruits of Xanthium strumarium, Including a New Neo-Lignan, and Their Anticancer Effects Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-27 Ye-Liang Wen; Min-Jing Li; Zhi-Jian Ye; Yue-Ming Liang; Xiao-Qun Wei
A new neo-lignan, (7′S,8′R)-4′,5′,9′-trihydroxy-4,6-dimethoxy-5,8′-oxyneolign-7-en-9-al (1), along with 5 known compounds (2-6), were isolated from the fruits of Xanthium strumarium. Their structures were elucidated by extensive spectroscopic methods. All the isolates were evaluated for in vitro cytotoxicities against the human cancer lines HepG2, A549, HCT-116, and SGC-7901. Compounds 1 and 3 showed
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In Vivo Efficacy of TXCB, a Vietnamese Herbal Medicine Prescription, on Seminal Quality, Serum Testosterone, and Malondialdehyde Concentration in Rabbits Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-27 Vu Ngoc Thang; Nguyen Thanh Ha Tuan; Pham Quoc Binh; Nguyen Minh Phuong; Thai Danh Tuyen; Doan Minh Thuy; Manh Hung Tran; Nguyen Hoang Ngan
The efficacy of Truong Xuan Cao Bang (TXCB), a Vietnamese herbal medicine prescription, on the quality of semen, serum testosterone (TES), and malondialdehyde (MDA) concentrations in rabbits whose reproductive ability were impaired by fluconazole was investigated. Mature male rabbits were randomly assigned into control (G1), fluconazole (G2), fluconazole and 180 mg/kg/day (G3), and 360 mg/kg/day TXCB
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Mechanism of Salviae Miltiorrhizae Radix et Rhizoma in the Treatment of Knee Osteoarthritis Based on Network Pharmacology Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-24 Xiaoqing Shi; Haosheng Zhang; Yue Hu; Xiaochen Li; Songjiang Yin; Runlin Xing; Nongshan Zhang; Jun Mao; Peimin Wang
Objective The molecular mechanism of Salviae Miltiorrhizae Radix et Rhizoma (SMRR) in the treatment of knee osteoarthritis (KOA) was analyzed based on network pharmacology. Methods Active components and potential targets of SMRR were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. KOA targets were obtained from the OMIM, DisGeNET, DrugBank, PharmGKB
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Matrine Can Inhibit the Growth of Colorectal Cancer Cells by Inducing Ferroptosis Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-22 Jingbo Wang; Peili Tang; Quan Cai; Sifang Xie; Xueyun Duan; Yuzheng Pan
Colorectal cancer (CRC) is a common malignant tumor of the digestive system that can seriously threaten human health. Chinese matrine is known to have a wide range of antiviral and immunomodulatory effects. In this study, we evaluated the effect of matrine on ferroptosis using the HCT116 human colon cancer cell line. We evaluated cell viability and proliferation using the cell counting kit-8 assay
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Simultaneous Determination of 5 Active Components of Periploca forrestii Schltr Extract in Rat Plasma by UPLC-MS and Its Application to Pharmacokinetic Studies in Normal and Adjuvant-Induced Arthritis Model Rats Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-21 Hui Liu; Hao Chen; Xiaoli Qin; Xue Ma; Zipeng Gong; Yueting Li; Siying Chen; Jie Pan; Aimin Wang; Lin Zheng; Yong Huang
Periploca forrestii Schltr (P. forrestii) is a herb used in traditional Chinese medicine for its anti-rheumatoid arthritis effect. The aim of this study was to compare the pharmacokinetic properties of the 5 active components of this plant: neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid C, and periplocin between normal rats and adjuvant-induced arthritis model rats
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Nanoliposomal Cercodemasoide A and Its Improved Activities Against NTERA-2 Cancer Stem Cells Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-21 Nguyen Thi Nga; Do Thi Phuong; Nguyen Thi Cuc; Trieu Ha Phuong; Pham Thi Mai Huong; Nguyen Xuan Cuong; Bui Huu Tai; Phan Van Kiem; Do Thi Thao
Recently, saponins derived from marine sources have received much attention because of their promising bioactivities, such as anticancer, anti-angiogenesis, and anti-inflammation. In particular, a triterpene saponin from the sea cucumber Cercodemas anceps Selenka, cercodemasoide A (CAN1), showed potent cytotoxicity against various cancer cell lines. Recent evidence has indicated that cancer stem cells
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Oral Administration of Salmon Cartilage Proteoglycan Attenuates Osteoarthritis in a Monosodium Iodoacetate-Induced Rat Model Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-21 Tuyen Danh Le; Hien Thi Thu Vu; Iddamalgoda Arunasiri; Kenichi Ito; Tadahiro Makise; Hang Thi Le; Truong Hong Nguyen; Lai Thi Hong Nguyen; An Thai Nguyen; Binh Quoc Pham; Phuong Thuy Pham; Ha Thi Thanh Nguyen; Minh Hong Phan; Long Hoang Luong; Van Anh Pham Thi
Proteoglycan (PG) is a type of glycoprotein which forms an extracellular matrix with collagen and hyaluronic acid to maintain articular cartilage, synovial membrane, and synovial fluid. This study aimed to evaluate the antiosteoarthritis effects of salmon nasal cartilage-derived PG in alleviating knee osteoarthritis in an osteoarthritis rat model. Knee osteoarthritis was induced in rats by intra-articular
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Anti-Inflammatory and Gastroprotective Effects of Escin Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-21 Yunqi Yang; Linlin Wang; Man Yuan; Qi Yu; Fenghua Fu
Escin is a triterpenoid saponin extracted from the fruit of Aesculus wilsonii Rehd. and Aesculus hippocastanum (Hippocastanaceae). Clinically, it is widely used in the treatment of edema induced by either trauma or surgery, as well as treating chronic venous insufficiency. The anti-inflammatory and antiedema effects of escin have been extensively investigated. This article systematically reviews the
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Editorial Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-20 Pawan K. Agrawal; Gerald Blunden
Cancer, one of the major causes of human morbidity and mortality, is a disease caused by the uncontrolled division of abnormal cells. Nature continues to produce a great wealth of natural molecules endowed with cytotoxic activity in the treatment of malignant diseases. Presently, natural products have played a pivotal role in cancer chemotherapy and chemoprevention for over half a century and provided
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Heptacyclosordarianone, a New Polyketide From Sordaria sp., an Endophytic Fungus From Garcinia polyantha Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-16 Virginie Flaure Tsague Tankeu; Denis Kehdinga Sema; Jean-Bosco Jouda; Simplice Joel N. Tatsimo; Patrick Akono Ntonga; Jean Duplex Wansi; Simeon Kouam Fogue; Benoît Loura; Yoshihito Shiono; Norbert Sewald; Alain Meli Lannang
One new polyketide derivative, heptacyclosordarianone (1), together with 2 known compounds, heptacyclosordariolone (2) and sordariol (3), were isolated from an extract of Sordaria sp. AM-71, an endophytic fungus inhabiting Garcinia polyantha. The structures of these compounds were elucidated based on intensive nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry and by comparison
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Chemical Composition and Antimicrobial Activities of the Essential Oil From the Leaves of Pterocephalus hookeri Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-15 Peng-fei Yang; Hui Lu; Qiong-bo Wang; Zhi-wei Zhao; Qiang Liu; Xu Zhao; Jing Yang; Shen Huang; Zhi-fei Chen; Duo-bin Mao
Detailed chemical constituents of essential oil from the Pterocephalus hookeri leaves and its antimicrobial activities were investigated in this study. The essential oil, obtained by hydrodistillation, was characterized by gas chromatography-flame ionization detection and gas chromatography-mass spectrometry analyses. Among the 90 identified compounds, hexadecanoic acid (21.27%), phytol (8.03%), furfural
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Synthesis and Antimicrobial Characterization of Luotonin Derivatives Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-11 Rui Zhu; Rui Guo; Ke Han; Wenying Xi; Shaojun Zheng; Jiwen Zhang
Twenty-one novel luotonin derivatives were synthesized from 2-aminobenzamide in excellent yields. The prepared compounds, when tested against 8 strains of bacteria and many plant pathogen fungi showed diverse and promising antimicrobial activities. Notably, compounds a5, a9, b4, and b5 demonstrated good activities and might be potential lead compounds for further development as antifungal agents. The
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Effects of Schisandra chinensis Extract on the Learning and Memory Ability of Mice With Learning and Memory Disorders Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-08 Zhao Lili; Tang Jing; Chen Ying; Jiang Ligang
The effect of Schisandra chinensis extract (SCE) on the learning and memory ability of mice with learning and memory disorders was investigated. After mice were given SCE prophylactically, different methods were used to establish mouse learning and memory disorders, and the radial maze test was used for the observation of SCE on the learning and memory ability of mice with learning and memory disorders
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Chemical Composition and Antibacterial Effect of Mentha spp. Grown in Estonia Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-08 Karmen Kapp; Tõnu Püssa; Anne Orav; Mati Roasto; Ain Raal; Pia Vuorela; Heikki Vuorela; Päivi Tammela
Mentha spp. are used in the food and pharmaceutical industry; the plants are characterized by natural interspecies hybridization. In this study, knowledge of the chemical composition of Mentha spp. was broadened by focusing on plants grown in a geographically small region of Estonia. The antibacterial activity of Mentha spp. essential oils and water extracts was evaluated. Polyphenolic water extracts
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Network Pharmacology Integrated Molecular Docking Reveals the Anti-COVID-19 Mechanism of Xingnaojing Injection Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-08 Bing Yu; Xin-Ge Ke; Chong Yuan; Peng-Yu Chen; Ying Zhang; Ning Lin; Yan-Fang Yang; He-Zhen Wu
In the process of fighting against COVID-19 in China, Xingnaojing injection has been recommended for its clinical treatment, but the information about its active components and mechanism is still lacking. Therefore, in this work, using network pharmacology and molecular docking, we studied the active components of Xingnaojing injection having anti-COVID-19 properties. Using the DL parameter, TCMSP
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Synergistic Anticancer Effect of Gemcitabine Combined With Impressic Acid or Acankoreanogein in Panc-1 Cells by Inhibiting NF-κB and Stat 3 Activation Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-04 Sen Jiang; Dong-Li Li; Jie Chen; Xi Zheng; Pan-Pan Wu; Chen Li; Xue-Tao Xu; Kun Zhang
Natural products have presented potentiality to improve the outcomes of cancer therapies. Impressic acid (E12-1) and acankoreanogein (E13-1), important activity compounds in Acanthopanax trifoliatus (L.) Merr., show widely biological activities. In this study, we isolated E12-1 and E13-1 from Acanthopanax trifoliatus (L.) Merr., and investigated their improvement effect in gemcitabine (GEM) treatment
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Systems Pharmacology Study of the Anticervical Cancer Mechanisms of FDY003 Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-04 Ho-Sung Lee; In-Hee Lee; Kyungrae Kang; Sang-In Park; Tae-Wook Kwon; Seung-Joon Moon; Chol Hee Lee; Dae-Yeon Lee
Increasing data support that herbal medicines are beneficial in the treatment of cervical cancer; however, their mechanisms of action remain to be elucidated. In the current study, we used a systems pharmacology approach to explore the pharmacological mechanisms of FDY003, an anticancer herbal formula comprising Lonicera japonica Thunberg, Artemisia capillaris Thunberg, and Cordyceps militaris (Linn
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Secondary Metabolites Isolated From Streptomyces sp. MJM3055 and Their Cytotoxicity Against Jurkat Cells Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-04 Yinda Qiu; Hee Min Yoo; Namki Cho; Pengcheng Yan; Zhiguo Liu; Jinhua Cheng; Joo-Won Suh
Bacteria of the genus Streptomyces are used in multiple applications in the medical field owing to their ability to generate large quantities of secondary metabolites. Chromatographic purification of Streptomyces sp. MJM3055 led to the isolation of 1 new streptenol derivative, 1-O-acetylstreptenol A (2), along with (3E,8E)-1-hydroxydeca-3,8-dien-5-one (1), streptenol A (3), cyclo-(L-Ile-L-Pro) (4)
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Preliminary Analysis of the Therapeutic Mechanism of Feiluoning in Convalescent Patients With COVID-19 Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-04 Zongchao Hong; Maolin Hong; Bo Liu; Ying Zhang; Yanfang Yang; Hezhen Wu
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), is often accompanied by injury to pulmonary function and pulmonary fibrosis. Feiluoning (FLN) is a new Chinese medicine prescription which is available for the treatment of severe and critical convalescence of COVID-19 patients. FLN also has a positive effect on pulmonary function injury and
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Tubeimoside-1 Protects Against Renal Ischemia Reperfusion Injury In Vivo and In Vitro Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-04 Xiaoli Yuan; Jing Wang; Yun Zhang
Renal ischemia reperfusion injury (RIRI) is one of the main causes of acute kidney injury. This study aimed to explore whether tubeimoside-1 (TBMS1) could protect against RIRI. RIRI mice model and hypoxia/reoxygenation (H/R)-induced NRK-52E cells were used in this study. The renal pathology was observed by hematoxylin and eosin staining to calculate the tubular injury score. The levels of serum creatinine
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Phytochemical Study on the Essential Oils of Tarragon (Аrtemisia dracunculus L.) Growing in Tajikistan and Its Comparison With the Essential Oil of the Species in the Rest of the World Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-03 Farukh S. Sharopov; Aminjon Salimov; Sodik Numonov; Mahinur Bakri; Zafar Sangov; Maidina Habasi; Haji Akber Aisa; William N. Setzer
The aerial parts of the tarragon (Artemisia dracunculus) were collected around Kukteppa village, Ziddi, Varzob region of Tajikistan. The essential oil of tarragon was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. Forty-five compounds representing 99.8% of total oil were identified. Sabinene (29.1%), estragole (24.6%), limonene (7.8%), (Z)-artemidin (4.9%), myrcene
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Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-03 Pawan K. Agrawal; Chandan Agrawal; Gerald Blunden
Quercetin, a naturally occurring dietary flavonoid, is well known to ameliorate chronic diseases and aging processes in humans, and its antiviral properties have been investigated in numerous studies. In silico and in vitro studies demonstrated that quercetin can interfere with various stages of the coronavirus entry and replication cycle such as PLpro, 3CLpro, and NTPase/helicase. Due to its pleiotropic
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Microbial Transformation of Flavonoids in Cultures of Mucor hiemalis Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-12-03 Bo-Ram Kim; Ah-Reum Han; Ik-Soo Lee
Flavonoids are plant secondary metabolites that are well known for their health-promoting properties as nutraceuticals in diets. Bioavailability and biological activities of flavonoids vary among the individual subclasses with different patterns of substitution, inclusive of glycosylation, to their basic structures. Many flavonoids exist as glycosides in plants. This study investigated the possibility
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Metabolic Analysis of Carotenoids and Phenolic Compounds Found in Green and Purple Kenaf Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-26 Chang Ha Park; Soon-Jae Kwon; Nam Su Kim; Seung-A Baek; Hyeon Ji Yeo; Ye Eun Park; Yong Suk Chung; Jae Kwang Kim; Sang Un Park
The chemical composition of the different plant parts of green (Hibiscus cannabinus L. cv. Jangdae) and purple (H. cannabinus L. cv. Jeokbong) kenaf cultivars were investigated using high-performance liquid chromatography. Ten carotenoid and phenolic compounds were quantified in the different parts of green and purple kenaf. The accumulation of carotenoids and phenolic compounds in the different parts
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Comparison of Chemical Compositions of the Pepper EOs From Different Cultivars and Their AChE Inhibitory Activity Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-26 Shu-Xia Chen; Kong Yang; Jia-Yao Xiang; Osafo Raymond Kwaku; Jia-Xin Han; Xian-Ai Zhu; Ya-Ting Huang; Le-Jiang Liu; Shao-Bin Shen; Hai-Zhou Li; Xing-Cong Li; Yang Feng; Min Xu
Pepper is one of the most popular spices over the world and is called the King of Spices. Its essential oils (EOs) could alleviate neuronal ailments due to the inhibitory effect against acetylcholinesterase (AChE). In this study, the chemical compositions of 26 EOs prepared from white and black pepper collecting from 6 different cultivars were analyzed by gas chromatography-mass spectrometry (GC-MS)
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Inhibitory Activity of 8 Alkaloids on P-gp and Their Distribution in Chinese Uncaria Species Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-25 Yanan Gai; Nannan Yang; Jian Chen
P-glycoprotein (P-gp) inhibition conduces to improving the ability of chemicals to cross through blood-brain barrier (BBB). The hook-bearing branch of Uncaria is used as a traditional herbal medicine for the treatment of hypertension, headache, stroke, and Alzheimer’s disease in recent years. In this study, the inhibitory effects of 8 alkaloids sourced from Uncaria plants on P-gp were evaluated. Meanwhile
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Hepatoprotective Effect of the Fruits of Polygonum orientale L. Against Carbon Tetrachloride-Induced Liver Fibrosis in Mice Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-24 Yung-Jia Chiu; Kun-Chang Wu; Jen-Chieh Tsai; Chun-Pin Kao; Jung Chao; Wen Huang Peng; Hao-Yuan Cheng
The aim of this study was to evaluate the hepatoprotective effects of the fruits of Polygonum orientale L. (POE) against fibrosis in carbon tetrachloride (CCl4)-induced liver injury. Bioactive components of POE were identified using liquid chromatography (LC)-mass spectrometry (MS)/MS by comparison with standards. Treatment with either silymarin (200 mg/kg) or POE (0.5 and 1.0 g/kg) caused significant
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Microbial Glycosylation of Phenanthrene and Bibenzyls by Mucor hiemalis Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-24 Bomi Nam; Ah-Reum Han; Ik-Soo Lee
Microbial transformation of denthyrsinin (1), gigantol (2), and batatasin III (3), the major constituents of Dendrobium species (Orchidaceae), was performed using the filamentous fungus Mucor hiemalis KCTC 26779. Three glycosylated metabolites were obtained in the biotransformation of 1-3, and their structures were identified as denthyrsinin-6-O-β-d-glucoside (4), gigantol-5-O-β-d-glucoside (5), and
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Characterization, Release Pattern, and Cytotoxicity of Liposomes Loaded With α-Mangostin Isolated From Pericarp of Mangosteen (Garcinia mangostana L.) Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-24 Thi Kieu Trang Phan; Toan Quoc Tran; Dung Thuy Nguyen Pham; Duong Thanh Nguyen
The pericarp of Garcinia mangostana L. is a rich source of α-mangostin, which exhibits a wide range of pharmacological and biological activities. However, clinical use of this compound is limited due to its low water solubility. Therefore, its formulation with various delivery systems has been developed. In the present study, α-mangostin was isolated from G. mangostana pericarp extract and loaded onto
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Erratum to “Stereoselective Synthesis of Spiroacetal Domain Derivatives of the Plant Glycoside Ranuncoside and of Okadaic Acid and Dinophysistoxins-1 and 2 From Marine Algae” Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-22
Cuny E. Stereoselective synthesis of Spiroacetal Domain Derivatives of the Plant Glycoside Ranuncoside and of Okadaic Acid and Dinophysistoxins-1 and 2 from Marine Algae. Nat Prod Commun. 2020;15(11):1–14. doi:10.1177/1934578X20971150
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Polyhydroxynaphthoquinone Pigment From Vietnam Sea Urchins as a Potential Bioactive Ingredient in Cosmeceuticals Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-23 Vo Mai Nhu Hieu; Tran Thi Thanh Van; Cao Thi Thuy Hang; Natalia P. Mischenko; Fedoreyev Sergey A.; Hai Bang Truong
In this study, valuable polyhydroxynaphthoquinone (PHNQ) pigments were recovered from sea urchin food waste and were investigated as a potential bioactive ingredient for cosmeceuticals. The crude PHNQ pigment extract from 4 Vietnam sea urchins, Diadema setosum, Diadema savignyi, Stomopneustes variolaris, and Tripneustes gratilla, exhibited effective 2,2-diphenyl-1-picryl-hydrazyl-hydrate scavenging
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Chemical Fingerprinting and Quantitative Analysis of Cortex Moutan From Different Tree Peony Cultivars Using HPLC-ESI/MS Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-23 Guodong Yang; Chunhui Zhang; Peng Li; Yan Qiu; Faming Dong
To evaluate the relationship between tree peony cultivars and the quality consistency of Cortex Moutan, a sensitive, reliable, and validated method based on high-performance liquid chromatography-electrospray ionization/mass spectrometry was developed for the quantitative analysis of paeonol and chemical fingerprinting of Cortex Moutan. Results from quantitative analysis showed that the content of
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Chemical Constituents of Tagetes patula and Their Neuroprotecting Action Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-23 Linlin Liu; Simin Luo; Miao Yu; Ahmed M. Metwaly; Xiaoku Ran; Chunyan Ma; Deqiang Dou; Decheng Cai
Two novel flavonoids (1, 2) and 3 known compounds (3-5) were isolated from the flowers and whole plant of Tagetes patula L., and their structures were elucidated by means of ultra-high performance liquid chromatography with electrospray ionization, coupled to quadrupole-time-of-flight/mass spectrometry, 1H and 13C-nuclear magnetic resonance (NMR), as well as 2-dimensional-NMR (heteronuclear single
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Sapindus mukorossi Seed Oil Changes Tyrosinase Activity of α-MSH-Induced B16F10 Cells Via the Antimelanogenesic Effect of Eicosenoic Acid Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-20 Yu-Hsiang Lin; Chia-Jen Nien; Lih-Geeng Chen; Sheng-Yang Lee; Wei-Jen Chang; Yu-Hwa Pan; Sung-Chih Hsieh; Haw-Ming Huang
Melanogenesis is a complex process that can lead to pigmentation defects. Various chemical skin-lightening products have been developed to treat pigmentation disorders. However, these chemical products can cause harmful adverse effects. Therefore, the development of safer, natural bleaching ingredients is a trend for sustainability. It has been reported that unsaturated fatty acids exhibit significant
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Corrigendum to In Vitro Culture for Ex Situ Conservation of “Roveja” and Nutritional Considerations on This Italian Rare Legume Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-18
Fraternale D, Bruno M, Rocchi L, Amicucci A, Ceccarini C, Ricci D. In vitro culture for ex situ conservation of “Roveja” and nutritional considerations on this Italian rare legume. Nat Prod Commun. 2018;13(9). doi:10.1177/1934578X1801300912
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In Vitro Anti-Inflammatory and Skin Moisturizing Properties of Pilea martini (Levl.) Hand.-Mazz. Extracts Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-18 Jieun Choi; Young Yun Jung; In Jin Ha; Seung Ho Baek; Zhiyun Zhang; Soo-Yong Kim; Yejin Hong; Sungyoon Kim; Hye Won Yeum; Sae-Rom Jeon; Kyungbok Park; Dongwoo Nam
The in vitro anti-inflammatory and skin moisturizing activities of Pilea martini (Levl.) Hand.-Mazz. were investigated on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and human immortalized keratinocytes. Chromatographic analysis was performed to identify the chemical composition of the extracts. Pilea martini extracts significantly suppressed LPS-induced nitric oxide, prostaglandin E2
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Variation in Headspace Volatiles of Saffron Determined by GC×GC-ToF-MS Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-11 Busisiwe N. Zwane; Guy P. Kamatou; Alvaro M. Viljoen; Georges Betti; Mathias Schmidt
Saffron, obtained from the stigmas of Crocus sativus L (Iridaceae), is the most expensive spice traded worldwide. In addition to its culinary uses, various medicinal properties have been confirmed for saffron, which has recently captured the interest of the phytotherapy industry. The quality of saffron is determined by the presence of 3 compounds, namely, crocin, picrocrocin, and safranal, with the
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Determination of the Solubility, Dissolution Enthalpy, and Entropy of Icariin in Acetone, Acetoacetate, Chloroform, and Light Petroleum Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-11 Jiao Xie; Kanghuai Zhang; Haitao Wang; Xin Yang; Wenbin Mao; Chenwei Liu; Na Wang
The solubility of icariin in acetone, acetoacetate, chloroform, and light petroleum in the 283.2‐318.2 K range was measured by ultraviolet-visible spectrophotometry. As the temperature increased, the solubility of icariin in the 4 solvents gradually increased. The solubility data correlated with the modified Apelblat equation. The dissolution enthalpy and entropy of icariin were determined using van’t
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A Unified Total Synthesis of Isocyclocapitelline and Cyclocapitelline Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-10 Marepally Srilatha; Vallabhareddy Satteyyanaidu; Chepyala Krishna Reddy; Venkata Subba Reddy Reddy Basireddy
A facile and concise synthesis of β-carboline alkaloids, such as (–)-isocyclocapitelline and (+)-cyclocapitelline, has been achieved from commercially available geraniol through a unified strategy. The key steps involved in this synthesis are Sharpless epoxidation, intramolecular ring opening of epoxide, Pictet-Spengler reaction, and dehydrogenative aromatization using 10% palladium/carbon in xylene
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Network Pharmacology Integrated Molecular Docking Analysis of Potential Common Mechanisms of Shu-Feng-Jie-Du Capsule in the Treatment of SARS, MERS, and COVID-19 Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-10 Ying Zhang; Yi Xie; Bing Yu; Chong Yuan; Zixin Yuan; Zongchao Hong; Hezhen Wu; Yanfang Yang
Shu-Feng-Jie-Du Capsules (SFJDCs) have been clinically proven to have a good therapeutic effect on COVID-19 in China. This study aimed to analyze the common mechanisms of SFJDC in the treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 via network pharmacology and molecular docking. We further explored the potential application value of SFJDC
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Curcumin Oligosaccharides (Gluco-oligosaccharides) Penetrate the Blood-Brain Barrier in Mouse Brain: Glycoside (Polysaccharide) Modification Approach for Brain Drug Delivery Across the Blood-Brain Barrier and Tumor Drug Delivery Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-09 Hiroki Hamada; Takahiro Nakayama; Kei Shimoda; Nobuyasu Matsuura; Hatsuyuki Hamada; Takafumi Iwaki; Yuya Kiriake; Tomohiro Saikawa
In order to expand our drug delivery technique by glycosylation of chemical into brain delivery, it was demonstrated that oligosaccharide and monosaccharide modifications of curcumin enhanced its crossing ability of the blood-brain barrier (BBB) in mice. The brain sample prepared by glycosidase-catalyzed hydrolysis of brain tissue homogenates of mice, to which curcumin gluco-oligosaccharides were intraperitoneally
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Protective Effect of Corynoline in Sepsis-Induced Acute Lung Injury in Rats via Inhibition of NF-ĸB Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-09 Min Shu; Yulu Tang; Jianzhen Liu
The present study was conducted to determine the effect of corynoline (COR) against sepsis-induced acute lung injury (ALI) in Wistar rats. Results of the study suggested that COR causes significant inhibition of lipid peroxidation (malondialdehyde) together with inhibition of oxidative stress (superoxide dismutase, catalase, glutathione peroxidase, and myeloperoxidase). The level of various proinflammatory
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Stereoselective Synthesis of Spiroacetal Domain Derivatives of the Plant Glycoside Ranuncoside and of Okadaic Acid and Dinophysistoxins-1 and 2 From Marine Algae Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-06 Eckehard Cuny
Spiroacetals constitute the central structural core element of numerous natural products and are mostly represented as bicyclic or tricyclic domains. Typical natural products with tricyclic spiroacetals are (+)-ranuncoside 1, a glycoside isolated from plants of the Ranuncalaceae family, and the algal toxins (+)-okadaic acid 2 and the (+)-dinophysistoxins-1 and 2 (3 and 4). These substances possess
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Sodium Houttuyfonate and Sodium New Houttuyfonate Affect the Composition of Gut Microbiota and Production of Inflammatory Factors in Mice Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-06 Guiming Yan; Yuanqing Si; Jing Shao; Tianming Wang; Changzhong Wang; Daqiang Wu
Houttuynia drugs, including sodium houttuyfonate (SH) and sodium new houttuyfonate (SNH), are derivatives of the active ingredient of Houttuynia cordata, which can be used as both a vegetable and medicine in China. We aimed to explore the regulation effects of SH and SNH on the gut microbiota and production of inflammatory factors in mice. Here, we found that SH and SNH led to an increase in the production
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Influence of Trehalose Mouth Rinse on Anaerobic and Aerobic Exercise Performance Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-11-05 Yoshio Suzuki; Kotaro Sato; Norie Arai; Shin Endo
Trehalose is a disaccharide consisting of 2 glucose units linked in an alpha 1,1-glycosidic bond. Pre-exercise trehalose ingestion enhances exercise performance within 30 minutes. Enhanced performance was hypothesized to be due to a mouth rinse effect. A 3-arm double-blind crossover trial was conducted to test this hypothesis. Ten healthy male collegiate distance runners rinsed their mouths with either
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Flavonoids and Xanthones From the Genus Iris: Phytochemistry, Relationships with Flower Colors and Taxonomy, and Activities and Function Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-30 Tsukasa Iwashina; Takayuki Mizuno
The genus Iris consists of approximately 360 species and is distributed to Eurasia, North Africa, and North America. Belamcanda chinensis was incorporated into the genus Iris by APG III as Iris domestica. Iris species have also been cultivated as ornamentals since ancient times. Many flavonoids are isolated and identified from the flowers, leaves, and rhizomes. So far as we know, 6 anthocyanidins,
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Anwulignan Alleviates Carbon Tetrachloride-Induced Acute Liver Injury in Mice Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-30 Zhang Yuchong; Zhang Xinyun; Wang Yao; Lin Huijiao; Yu Chunyan; Jing Shu; Zhuang Wenyue; Wang Chunmei; Sun Jinghui; Li He; Chen Jianguang
Acute liver injury is a serious threat to human health. Complementary therapy including a traditional Chinese herb has been used for the prevention and treatment of liver injuries. Schisandrae sphenantherae fructus (Schisandra) is the mature dry fruit of Schisandra sphenanthera Rehd. et Wils. Wuzhi capsule, a preparation containing Schisandra and its main component anwulignan, is used to treat hepatitis
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Study on Preparation of a Chitosan/Vitamin C Complex and Its Properties in Cosmetics Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-27 Liu Liping; Li Kexin; Ding Huipu; Lv Jia; Zhang Jie
In order to expand the application of chitosan in cosmetics, it was modified with vitamin C to prepare a chitosan/vitamin C complex (CSVC complex), which was characterized using ultraviolet-visual, Fourier transform infrared, and differential scanning calorimetry techniques. Its hygroscopicity, moisture retention, antioxidant and antibacterial activities, and environmental stability were also determined
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Simultaneous Determination of 6 Antiallergic Components in Asarum sieboldii Using High-Performance Liquid Chromatography Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-27 Seol Jang; Sun Haeng Park; Ho Kyoung Kim
Owing to the side effects of current drugs for treating atopic dermatitis (AD), a chronic disease in the skin, traditional herbal medicine is receiving much attention as an alternative treatment. Asarum sieboldii has traditionally been used to treat colds, fevers, headaches, coughs, neuralgia, chronic bronchitis, asthma, and allergies. In this study, 6 compounds (echinacoside, vanillic acid, kakuol
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Isolation of Prunin From Bauhinia variegata and Its Antioxidant Activity in Rats Fed an Atherogenic Diet Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-27 Xi Zhang; Binghua Ye
Atherosclerosis is no longer a disease attributed mainly to high cholesterol content in the body; it has come to be regarded as a chronic inflammatory disease with an autoimmune component. The purpose of this study was to investigate the effect of the prunin fraction (PF) isolated from the ethanolic extract of Bauhinia variegata against the release of various proinflammatory mediators in rats fed an
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Influence of Decoction Duration of FDY2004 on Its Physicochemical Components and Antioxidant and Antiproliferative Activities Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-27 In-Hee Lee; Ho-Sung Lee; Kyungrae Kang; Sang-In Park; Tae-wook Kwon; Seung-Joon Moon; Chol Hee Lee; Dae Yeon Lee
FDY2004 (Medicinal herbs: Rheum palmatum, Paeonia suffruticosa Andrews, and Prunus davidiana), an herbal drug composition with an antiproliferative effect, is prepared by boiling, which is the most common herbal extraction method in traditional Korean medicine. Several parameters are considered in the process, including herb-to-solvent ratio, extraction temperature and pressure, and total decoction
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GC-FID-MS and X-ray Diffraction for the Detailed Evaluation of the Volatiles From Senecio filaginoides Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-27 Catalina M. van Baren; Silvia B. González; Arnaldo L. Bandoni; Paola Di Leo Lira; María A. Bucio; Angelina Hernández-Barragán; Pedro Joseph-Nathan
The medicinal aromatic plant Senecio filaginoides DC, which is very widespread in the Patagonia region, was harvested at the vegetative, flowering, and fructification stages. The materials were extracted by hydrodistillation, yielding in average 0.34% v/w of essential oils with a pleasant sweet and greenish scent. A total of 56 components were identified by gas chromatography using flame ionization
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Antioxidant and Anti-Inflammatory Effects of Diallyl Disulfide on Hepatotoxicity Induced by Cyclophosphamide in Rats Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-27 Hesham Farouk Hasan; Gehan Roushdy Abdel-Hamid; Sahar Ismail Ebrahim
Diallyl disulfide (DADS) is a garlic-derived organo-sulfur compound. This study was carried out to investigate the protective potential, antioxidant, and anti-inflammatory effects of this compound against cyclophosphamide (CP)-induced hepatotoxicity in rats. A single intraperitoneal dose of CP (200 mg/kg) resulted in a significant disturbance in hepatic function and oxidative stress, as well as inflammatory
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A New Phenylethanoid Glycoside From the Leaves of Rosmarinus officinalis With Nitric Oxide Inhibitory Activity Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-27 Le Thi Huyen; Le Thi Oanh; Nguyen Thi Son; Nguyen Thi Minh Thu; Nguyen Huy Hoang; Pham Hai Yen; Nguyen Xuan Nhiem; Bui Huu Tai; Phan Van Kiem
A new phenylethanoid glycoside, named rosmacinalis (1), and 6x known compounds {2-phenylethyl O-α-L-rhamnopyranosyl-(1‴→6″)-O-β-D-glucopyranoside (2), clinopodiolide C (3), rosmanol (4), 7α-methoxyrosmanol (5) 7β-methoxyrosmanol (6) and carnosol (7)} were isolated from the leaves of Rosmarinus officinalis. Their structures were determined by extensive analysis of high-resolution electron spray ionization
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Anxiety Therapeutic Interventions of β-Caryophyllene: A Laboratory-Based Study Nat. Prod. Commun. (IF 0.468) Pub Date : 2020-10-23 Keylla da Conceição Machado; Márcia Fernanda Correia Jardim Paz; José Victor de Oliveira Santos; Felipe Cavalcanti Carneiro da Silva; Jana Dimitrova Tchekalarova; Bahare Salehi; Muhammad Torequl Islam; William N. Setzer; Javad Sharifi-Rad; João Marcelo de Castro e Sousa; Ana Amélia de Carvalho Melo Cavalcante
The bicyclic sesquiterpene β-caryophyllene (BCP) has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, and analgesic effects. This study evaluates anxiolytic, toxicity, and antioxidant effects of BCP using in vitro and in vivo test models. The anxiolytic effects were tested in Swiss albino mice (Mus musculus) by applying the elevated plus-maze, rota-rod, light and
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