Aldimine/ketamine condensations are basic reactions in chemical synthesis. Herein a density functional theory (DFT) study was performed to characterize the mechanism of the ketamine condensation of acetophenone with tert ‐butanesulfinamide catalyzed by NaOH. The calculated results showed that the main N‐tert ‐butanesulfinimines products own E configuration, which are due to both thermodynamic and kinetic

An efficient method for the enantio‐ and diastereoselective construction of furanochromanones has been developed through Pd‐catalyzed asymmetric allylic cycloaddition of vinylethylene carbonates with 3‐nitrochromone. By using a palladium complex generated in situ from [Pd 2 (dba) 3 ]·CHCl 3 and phosphoramidite L 4 as a catalyst, the transformation allows to rapid access furanochromanones bearing versatile

A novel metal‐free catalytic one‐pot approach has been developed for the esterification of aralkyl ketones with alcohols under open‐air atmospheric conditions. The inexpensive iodide/oxone reagent system allowed the cascade C(sp3)‐H bond oxygenation, selective C‐C bond cleavage and esterification through the both radical and ionic pathways in a stepwise manner in one‐pot. This mild, convenient and

We report the preliminary results of an investigation comprising of the synthesis of 1‐naphthol‐based unsymmetrical triarylmethanes via Pd‐catalyzed Heck‐type desulfitative reaction and conjugate addition of arylsulfonyl chlorides with tetralone‐derived chalcones. Unsymmetrical triarylmethanes are valuable molecules in organic‐, medicinal and materials chemistry. This work is a contribution towards

Due to the atom‐economic and greener nature, borrowing hydrogen (BH) and acceptorless dehydrogenative coupling (ADC) processes have drawn significant attentions of the researchers across the globe and thus, these strategies have been extensively utilized in synthetic chemistry to access various challenging and valuable compounds. During the last decade, significant progress has been witnessed in the

An efficient electrolyte‐triggered trifluoromethylation and halogenation at C5 positions of 8‐aminoquinoline derivatives was developed, affording the C‐H functionalization products in moderate to excellent yields. What's more, the mild and green reaction revealed lower energy and shorter time consumption. Most importantly, the requirements for both transition metal catalysts and oxidants were avoided

A sequential one‐pot method for the synthesis of 4‐(hydroxymethyl)oxazoles from readily available benzamides has been developed. Various substituted benzamides well‐tolerated and furnished 4‐(hydroxymethyl)oxazoles in moderate to good yields under the present reaction conditions. In order to demonstrate the usefulness of the present methodology, the resulting 4‐(hydroxymethyl)oxazoles were successfully

Aryl diazonium salts are important molecules in organic chemistry. This review discusses advances of their application in light‐mediated reactions summarized in five categories according to the bond formations: (1) C‐C formation from alkenes, alkynes, arenes, isocyanide, CO, arylboronic acid, or Grignard reagent. (2‐5) C‐B, C‐N, C‐S, and C‐P formations. Reactions like the radical addition, elimination

Stoichiometric amounts of various oxidants have long been employed for the oxidation of organic compounds. The major drawback of this method is the amount of toxic waste produced, which is in sharp contrast to principles of green chemistry. In catalytic dehydrogenation pathway, hydrogen carrier organic compounds (HCOCs) containing O‐H, C‐H, and N‐H bonds can be transformed to the oxidized form by removing

A visible‐light‐induced radical difluoromethylation of alkynoates using [bis(difluoroacetoxy)iodo]benzene as the CF 2 H radical precursor was developed for the first time. 3‐Difluoromethyl‐substituted coumarins were synthesized via a radical difluoromethylation/cyclization/ester migration cascade. The mild and catalyst‐free conditions, as well as the good functional group tolerance, render this protocol

A new NFSI/KF‐mediated scission/recombination of C−C double bonds for [4 + 1] annulation was first reported, leading to the efficient synthesis of a wide range of fully substituted oxazoles in good to excellent yields under the mild neutral‐redox conditions. This methodology might open a new entry for the preparation of structurally applicable heterocyclic systems in a highly functional‐group‐compatible

A redox entanglement in photoredox catalysis is discovered and discussed. Using MeOH as a proton source and Eosin Y as the photocatalyst, a problematic and redox‐neutral perfluoroalkylation/cyclization cascade of alkenes with perfluoroalkyl iodides might be streamlined, furnishing perfluoroalkylated indolines, indoles, dihydroisoquinolinones, and indolin‐2‐ones with a good functional‐group tolerance

An unprecedented formal [5 + 2] cyclization of N,N′‐cyclic azomethine imines with triazines has been realized, which provides a facile access to biologically important 1,2,4,6‐tetrazepine frameworks with overall high yields (up to 98% yield). This methodology is distinguished by not involving a metal catalyst, readily available starting materials, and operational simplicity, which involves the reassembly

Herein, we report a simple, efficient, and sustainable method for the synthesis of α‐alkylated ketones and quinolines using the borrowing hydrogen strategy, which has emerged as a greener alternative in organic transformation reactions. Synthesis of a range of α‐alkylated ketones and quinoline derivatives was achieved by using the water‐soluble [Ru(8‐AQ)Cl(p‐cym.)]+Cl− [Ru]‐1 (AQ = aminoquinoline)

A visible‐light‐mediated reaction of N ‐phenylpropynamides with diethyl 2,2‐dibromomalonate for the synthesis of bromo‐containing azaspirotrienediones is described. This method allows the formation of C‐Br, C‐C and C=O bonds in one pot through the radical addition/ipso‐cyclization/oxidation cascade reaction. A possible radical mechanism involving single electron transfer and energy transfer processes

Novel moisture‐sensitive binary films that exhibit reversible change in fluorescent color have been created using a fluorescent amorphous molecular material, 4‐[bis(4‐methylphenyl)amino]benzylideneaniline (BMBZA), with organic acids such as pentafluorobenzoic acid and benzoic acid. Orange fluorescent color of the film under ambient dry atmosphere was found to change drastically to greenish blue under

An anion controlled stereodivergent semi‐hydrogenation of alkynes is reported. The reactions are catalyzed by the low‐cost and stable nickel(II) salts, using water as environmental friendly hydrogen source with zinc powder as metal reductant. Interestingly, the stereoselectivity of the reaction is well controlled by the anion of the nickel(II) salt. The present methodology allowed a low‐cost and convenient

Herein, we report a C–S cross‐coupling reaction between alkyl thiols or aryl thiols and ortho ‐substituted arylboronic acids that proceeds in the presence of an inexpensive and ligand‐free NiCl 2 ·6H 2 O salt and N ‐methylmorpholine, a weak base, at 25 °C in air. The presence of coordinating and electron‐withdrawing groups at the ortho ‐position of the arylboronic acids played a crucial role in determining

We synthesized a new water‐soluble tribenzotriquinacene‐based hexacarboxylate ( TBTQ‐C 6 , or H ) which can associate with an azobenzene‐containing amphiphile ( trans ‐AZO ) to form the H · trans ‐AZO supra‐amphiphile by host‐guest interactions in water. This supra‐amphiphile further self‐assembles into photo and pH dual‐responsive vesicles. The reversible conversion between the vesicles and micelles

Production of chiral compounds by green processes like domino reactions is of importance to environmental protection and sustainable development. Nevertheless, finding an appropriate catalyst to control enantioselectivity with satisfaction is a major challenge. Here, we report the accomplishment of a newly developed domino reaction for synthesizing optically active 3‐pyrrolines, a class of compounds

The development of a diastereoselective intramolecular rhodium‐catalyzed [(3+2+2)] carbocyclization reactions of allyl ester‐tethered alkynylidenecyclopropanes (ACPs) for the construction of the 5,7,5‐tricyclic scaffold of the tremulane sesquiterpene natural products is described. This work illustrates that the stereoelectronic nature of the phosphite ligand is critical for attaining high levels of