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Synthesis, characterization and in vitro antiproliferative effects of isosteviol derivatives J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-03-13 Xin-Xin Qi, Pan-Pan Wang, Lan-Tian Cui, Mei Jin, Long-Xuan Zhao, Gao Li
Nineteen isosteviol derivatives were designed and synthesized by C-16, C-19 and D-ring modifications of isosteviol. These compounds were screened for their cytotoxic activities against Hela and A54...
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Antinociceptive iridoid glycosides from the aerial parts of Paederia foetida J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-03-12 Yu-Feng Chen, Wei Gong, Qing-Jie Zhao, Chong Liu
Two previously undescribed iridoid glycosides, 6'-O-trans-feruloyl-(4S,6R)-3,4-dihydro-3β-ethoxypaederoside (1) and 6'-O-trans-caffeoyl-(4S,6R)-3,4-dihydro-2'-O-3α-paederoside (2), were isolated fr...
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Triterpenoids from Juglans mandshurica with anti-hyaluronidase activities J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-03-12 Ze-Chen Qi, Qiu-Han Chen, Zeng Xu, Chen Yang
Phytochemical study on 90% ethanol extract from the green walnut husks of Juglans mandshurica Maxim. resulted into the isolation of three undescribed triterpenoids, juglansmanoids A–C (1–3). Struct...
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Special issue in honor of Professor De-Quan Yu J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-03-04 Shi-Shan Yu
Published in Journal of Asian Natural Products Research (Ahead of Print, 2024)
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Two new cassane diterpenoids from the seed kernels of Caesalpinia sinensis J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-03-01 Lian Lian, Yue-Lin Zhao, Tian-Jian Zhang, Miao Wang, Hui-Yuan Gao
Two new cassane diterpenoids, sucupiranin MN (1) and sucupiranin ML (2), together with two known compounds sucutinirane C (3) and deacetylsucutinirane C (4) were isolated from the seed kernels of C...
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Natural products and their derivatives alleviating cerebral white matter lesions J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-28 Jing-Wen Ning, Cai-Xia Zang, Mei-Yu Shang, Xiu-Qi Bao, Dan Zhang
White matter lesions (WMLs), characterized by focal demyelination or myelination disorders, are commonly present in cerebral small vessel disease and various neurological diseases. Multiple etiolog...
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New aporphine alkaloids with antitumor activities from the roots of Thalictrum omeiense J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-22 Zhao-Jing Chen, Han-Gao Yang, Wen-Peng Zhu, Chun-Mei Xue, Hong-Mei Zhang, Yu-Ting Peng, Da-Hong Li, Hui-Ming Hua
Two new aporphine alkaloids, 6aR-2'-(3-oxobutenyl)-thaliadin (1) and N-methylthalisopynine (2), along with ten known analogs (3–12), were isolated from the roots of Thalictrum omeiense W. T. Wang e...
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Coumarins and flavones with anti-inflammatory activity isolated from the branches and leaves of Daphne retusa J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-19 Yang Xu, Yu-Xia Li, Kui-Ru Sa, De-Juan Sun, Hua Li, Li-Xia Chen
In this study, two new (1, 13) and fourteen known (2–12, 14–16) compounds were isolated from the branches and leaves of Daphne retusa. On the basis of chemical evidence and spectral data analysis (...
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The basic chemical substances of total alkaloids of Uncaria rhynchophylla and their anti-neuroinflammatory activities J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-19 Jia-Xu Qin, Yang Hong, Lu-Yi Zhao, Chao-Qun Wang, Xin Fang, Shuang Liang
To clarify the chemical basis of the total alkaloids of Uncaria rhynchophylla, HPLC-VWD chromatogram of total alkaloids was established. Under its guidance, modern chromatographic and spectroscopic...
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Protein kinase inhibitors in the management of cancer: therapeutic opportunities from natural compounds J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-19 Himanshu Singh, Rajnish Kumar, Avijit Mazumder
Kinase is an enzyme that helps in the phosphorylation of the targeted molecules and can affect their ability to react with other molecules. So, kinase influences metabolic reactions like cell signa...
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Morushalunin D, a tri-O-bridged Diels-Alder type adduct from Morus alba var. shalun root cultures and the related precursors J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-20 Rizki Fitriani, Nizar Happyana, Euis Holisotan Hakim
Three Diels-Alder type adducts (1-3) along with their precursors, including one 2-arylbenzofuran (4) and one stilbene (5), were isolated from the MeOH extract of M. alba var. shalun root cultures. ...
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Triterpenoids from the hook-bearing stems of Uncaria rhynchophylla J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-20 Xin-Yu Liu, Xin-Nuo Tong, Xiao-Min Liang, Qiang Guo, Peng-Fei Tu, Qing-Ying Zhang
An unprescribed nortriterpenoid with an aromatic E ring, uncanortriterpenoid A (1), together with fourteen known triterpenoids (2–15), were isolated from the hook-bearing stems of Uncaria rhynchoph...
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New sesquiterpenoids from Biscogniauxia sp. J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-14 Meng Zhang, Huan Zhao, Jing-Wen Kong, Mei-Gu Chen, Qing Yang, Wei Xu, Dan Hu, Liang-Dong Guo, Guo-Dong Chen, Hao Gao
Five new sesquiterpenoids, including a campherenane-type (1), a bergamotane-type (2), a drimane-type (3), and two bisabolane-type (5-6) sesquiterpenoids have been isolated from Biscogniauxia sp. 71...
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Exploring the mechanism of daphne-type diterpenes against gastric cancer cells J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-12 Yu-Jue Wang, Xin-Ye Wang, Zi-Nuo Yang, Xin-Yue Shang, Si-Hui Mi, Qingbo Liu, Guo-Dong Yao, Shao-Jiang Song
Gastric cancer is one of the common malignant tumors. It is reported that daphne-type diterpenes have inhibitory effects on gastric cancer cells, but the mechanism is still unknown. To explore the ...
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Facile synthesis and cytotoxicity of substituted uracil-1'(N)-acetic acid and 4-pyridone-1'(N)-acetic acid esters of 20(S)-camptothecins J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-12 Di-Zao Li, Zhao-Di Fu, Hong-Yan Liu, Xian-Dao Pan
A series of novel substituted uracil-1'(N)-acetic acid esters (5–9) and 4-pyridone-1'(N)-acetic acid esters (10–11) of 20(S)-camptothecins (CPTs) have been synthesized by the acylation method. All ...
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New polyketides from the starfish-derived symbiotic fungus Penicillium sp. GGF16-1-2 J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-09 Yu-Pei He, Jun Xiang, Xue-Hua Shao, Chan Feng, Qi Zhang, Yu-Mei Wang, Cui-Xian Zhang
One new rare carbon-bridged citrinin dimer quinocitrindimer C (1) as a pair of epimers, two new polyketide penicilliodes D (3) and E (4) together with nine known citrinin derivatives, were isolated...
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A gene cluster encoding a nonribosomal peptide synthetase-like enzyme catalyzes γ-aromatic butenolides J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-08 Qing-Zhou Meng, Xin-Zhu Wang, Huan-Qin Dai, Israa Assani, Meng-Ting Zhang, Pei-Pei Zhao, Long-Fen Li, Xin Yin, Jun Qi, Yang Pan, Li-Xin Zhang, Xue-Kui Xia
Sea cucumber-derived fungi have attracted much attention due to their capacity to produce an incredible variety of secondary metabolites. Genome-wide information on Aspergillus micronesiensis H39 o...
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A new flavonolignan from milk thistle (Silybum marianum) J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-08 Waed Hammad, Nuha Sweidan, Musa Abu Zarqa
A new flavonolignan, sonyamandin (1), along with other known compounds was isolated from the aerial parts and seeds extracts of Silybum marianum (milk thistle) collected from Jordan. The known ones...
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New withanolides from leaves along with alkyl glucoside from roots and stem as well as variations in withanolide contents in leaves of accessions of Withania somnifera, Ashwagandha- the Indian ginseng$ J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-04 Payare Lal, Laxminarain Misra, Neelam S. Sangwan, Rajender S. Sangwan
Based on the major components in the leaves, the ashwagandha has been found to exist in several chemotypic forms in India. From the leaves of various accessions of Withania somnifera, which were ma...
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Progress of studies on natural products for glioblastoma therapy J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-06 Fang Xu, Yi-Hui Yang, Hong Yang, Wan Li, Yue Hao, Sen Zhang, Yi-Zhi Zhang, Wan-Xin Cao, Xiao-Xue Li, Guan-Hua Du, Teng-Fei Ji, Jin-Hua Wang
Glioblastoma (GBM) is the most common, malignant, and lethal primary brain tumor in adults. Up to now, the chemotherapy approaches for GBM are limited. Therefore, more studies on identifying and ex...
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New depside and rosmarinic acid derivatives from Perilla frutescens and their anti-inflammatory activity J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-02-02 Teng Ma, Jia-Qi Chen, Tie Yao, Bing-Yang Zhang, Feng Qiu
Two new depside derivatives 1 and 2 as well as a new pair of rosmarinic acid enantiomers 3a/b were isolated from the leaves of Perilla frutescens (L.) britt. The chemical structures of these compou...
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Sesquiterpenoids from cigar tobacco leaves J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-30 Chen-Xi Zhang, Guang-Hai Zhang, Guang-Hui Kong, Xiang-Hai Cai
Phytochemical investigation on cigar tobacco leaves led to four unknown sesquiterpenoids as well as nine reported ones. Among of them, 3-acetoxy-β-damascone was first found in tobacco leaves. All t...
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Two new Nb-oxide indole alkaloids with β-hematin inhibitory activity from the stems and leaves of Rauvolfia dichotoma J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-21 Jing-Ru Fang, Yu-Jie Zhang, Xiao Meng, Yi Chen, Xue Zhang, Ling-Juan Zhu, Xin-Sheng Yao
Rauvolfia dichotoma, a shrub of Apocynaceae, was collected from the Islands of SAO Tome and Principe and cultivated locally for medicinal purpose. Phytochemical investigation of 95% ethanol extract...
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Sesquiterpenes from Wikstroemia lungtzeensis with anti-neuroinflammatory effects J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-17 Yan-Ping Zhang, Ying-Jie Wang, Yan Mi, Zi-Song Bai, Sheng-Ze Tang, Wei Li, Gang Chen, Yue Hou, Ning Li
An anti-neuroinflammatory activities-guided phytochemical research of Wikstroemia lungtzeensis was performed for the first time. Three undescribed carotane-type sesquiterpenes, excoecafolinols C-E ...
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Astragaloside IV targeting autophagy of T cells improves inflammation of asthma J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-11 Qing-Qing Yang, Hong-Ying Zhang, Xiao-Hong Duan, Mi-Hui Li, Jing Sun, Li-Xia Tian, Jing-Cheng Dong, Ling-Wen Kong
Astragaloside IV (AST) has been confirmed to have antiasthmatic effects. However, the underline mechanism is unclear. The study aimed to explore the treatment mechanism of AST based on autophagy of...
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New caffeoyl derivatives with potent DPPH radical scavenging activity from Elephantopus tomentosus J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-09 Meng-Yao Zhang, Shi-Lin Chen, Chun-Yu Lin, Hai-Xin Zhang, Tao Zhang, Zhong-Mei Zou
Eight new caffeoyl derivatives, elephantomentosides A–H (1 − 8), together with ten known ones (9 − 18), were isolated from the whole plant of Elephantopos tomentosus L. Their structures were elucid...
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A new cytotoxic disaccharide glycoside from the tubers of Arisaema franchetianum J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-12 Yun-Peng Qin, Wan-Qi Yang, Kai-Dong Liu, Yong Xu, Ying-Ying Dong, Jiang Fu, Jing Qu, Shi-Shan Yu
A new disaccharide glycoside, franchoside A (1), and 17 known compounds were isolated from the tubers of Arisaema franchetianum Engler. The chemical structure of the previously undescribed compound...
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Cadinane sesquiterpenes from the stems and branches of Illicium ternstroemioides J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-11 Jia Yang, Jian-Pei Zhang, Rong-Mei Gao, Wen-Rui Li, Jing-Yu Zhang, Qian-Ru Wang, Mi Li, Hai-Qiang Wang, Guo-Zhu Su, Li Li, Yu-Huan Li, Ru-Bing Wang, Xiao-Jing Wang, Shuang-Gang Ma
Three new cadinane sesquiterpenes (1–3) and three known sesquiterpenes were isolated from the stems and branches of Illicium ternstroemioides A. C. Smith. The structures of the new compounds were e...
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A novel [1, 2, 4]triazolo[5,1-b]quinazoline derivative as a fluorescent probe for highly selective detection of Fe3+ ions J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-09 Zhen-Peng Li, Han Zhao, Zi-Han Zhang, Zhong-Xuan Qiu, Xiu-Fen Li, Long-Jiang Huang
A novel [1, 2, 4]triazolo[5,1-b]quinazoline fluorescent probe (VIi) for Fe3+ was developed, featuring with rapid response (< 5 s) and specific selectivity to Fe3+, low detection limit (1.3 × 10−5 M...
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Pseudoamaolide P, a 1,2:3,4:9,10:9,19-tetraseco-cycloartane triterpene spiroketal lactone from seeds of Pseudolarix amabilis J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-09 Yu-Xun Zhu, Shang-Yi Wang, Cheng-Shuo Yang, Zhao-Xin Zhang, Huan-Ping Zhang, Li-Sha Chai, Guo-Zhu Su, Yong Li
A 1,2:3,4:9,10:9,19-tetraseco-cycloartane triterpene spiroketal lactone, pseudoamaolide P (1), two new labdane-type diterpenoids, pseudoamains A and B (2-3), and four known cembrane-type diterpenoi...
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Bioactive neolignan, iridoid and flavonoid glycosides from the leaves of Vaccinium bracteatum J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-08 Yin-Yin Wang, Jun-Jiang Li, Quan-Hao Wei, Xin-Xin Wang, Jun-Sheng Zhang, Jun-Jie Yan, Hua Zhang
Two neolignan glycosides including a new one (1), along with seven iridoid glycosides (3 − 9) and nine flavonoid glycosides (10 − 18), were isolated from the leaves of Vaccinium bracteatum. Their s...
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Phenolic and flavonoid compounds from the fruit shell of Camellia oleifera J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-08 Qing Shu, Yi-Xia Liu, Yu-Jun Tang, Huai-Yu Cheng, Ya-Yu Wu, Wei Xu, Yu-Bo Zhang, Guang-Xiong Zhou
A new phenolic compound oleiphenol (1), and a new dihydrochalcone oleifechalcone (2) along with seven known compounds (3-9) were isolated from the fruit shell of Camellia oleifera Abel. The planar ...
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Tautomeric cinnamoylphloroglucinol-monoterpene adducts from Cleistocalyx operculatus and their antiviral activities J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-08 Jian-Guo Song, Jia-Xin Liu, Rui-Li Huang, Wei Tang, Xiao-Jun Huang, Ying Wang, Wen-Cai Ye
Guided by 1H NMR spectroscopic experiments using the characteristic enol proton signals as probes, three pairs of new tautomeric cinnamoylphloroglucinol-monoterpene adducts (1–3) were isolated from...
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Six new iridoid glycosides from the whole plants of Hedyotis diffusa J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-07 Huan-Huan Gao, Ling-Feng Qin, Xu Zhang, Xiang Yuan, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang, Ya-Nan Yang
Six new iridoid glycosides were isolated from the ethyl acetate fraction of the whole plants of Hedyotis diffusa Willd. They were identified as E-6-O-p-methoxycinnamoyl-10-O-acetyl scandoside acid ...
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Structurally diverse triterpenoid alkaloids from Buxus rugulosa J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-08 Yu-Huan Wang, Le-Tian Cui, Yu-Jin Sun, Yong-Yi Li, Jun Luo, Ling-Yi Kong
Four new nortriterpenoid alkaloids, namely buxrugulines E–H (1–4), along with five known ones (5–9), were isolated from the twigs and leaves of Buxus rugulosa. Their structures were identified base...
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Dihydrophenanthro[b]furan derivatives from the tubers of Bletilla striata J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2024-01-02 Mo-Han Sun, Xian-Jie Ma, Si-Yuan Shao, Jian-Wei Jiang, Jian-Jun Zhang, Shuai Li
Two pairs of new dihydrophenanthro[b]furan enantiomers blephebibnols G–H (1–2), one new dihydrophenanthro[b]furan derivative blephebibnol I (3), along with four known analogues (4–7), were isolated...
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Survey of natural products reported by Asian research groups in 2022 J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-12-27 Yan-Fei Liu, Shi-Shan Yu
The new natural products reported in 2022 in peer-reviewed articles in journals with good reputations were reviewed and analyzed. The advances made by Asian research groups in the field of natural ...
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Exploring the catalytic diversity of two short-chain dehydrogenases/reductases from Stachybotrys chartarum J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-12-21 Yu-Xin Wang, Xin-Yu Cai, Ji-Mei Liu, Yao-Tian Han, Song-Yang Sui, Da-Wei Chen, Ke-Bo Xie, Ri-Dao Chen, Jun-Gui Dai
Short-chain dehydrogenase/reductases (SDRs) belong to the NAD(P)(H)-dependent oxidoreductase superfamily, which have various functions of catalyzing oxidation/reduction reactions and have been gene...
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Two new bibenzyl methylglucosides as SIRT3 activators obtained through microbial transformation J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-12-11 Yue Wang, Wei-Cheng Fu, Yu Peng, Ying-Lu Zhang, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang, Ting Gong, Ping Zhu
Microbial transformation of dihydroresveratrol (DHRSV) using Beauveria bassiana has produced two new methylglucosylated derivatives of DHRSV (1 and 2), whose structures were characterized as 4′-O-(...
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Two pairs of 2-pyrone enantiomers and a benzophenone analogue from the endophytic fungus Penicillium egyptiacum J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-12-05 Xiao-Ming Zheng, Ya-Long Zhang, Hong Yang, Jian Bai, You-Cai Hu
Four new 2-pyrone derivatives, two pairs of enantiomers, (±)-egypyrone A [(±)-1] and (±)-egypyrone B [(±)-2], together with a new benzophenone analogue, orbiophenone B (3), were isolated from the e...
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Targeted chemical profiling for p-HAP glycosides by using molecular networking and comparative analysis of their contents between Artemisia japonica and Artemisia capillaris J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-11-30 Chen Zhang, Su-Qing Zhao, Wen Kang, Hang Ma, Xiao-Ying Li, Wen-Bin Zhou, Zeper Abliz
A total of 65 phenolic acid compounds were annotated or identified by UHPLC-MS/MS method, among them, 17 p-HAP (p-hydroxyacetophenone) glycosides were firstly targeted profiled based on molecular n...
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Aculebiphenyl A–B, new biphenyl derivatives from Ruscus aculeatus J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-11-24 Sheng-Li Niu, Jia-Hui Hao, Jing-Yi Xu, Qi Guan, Zhen-Chi Zhou, Tian-Meng Lv, Ya-Ting Sun
The investigation of chemical constituents from the rhizomes of Ruscus aculeatus resulted in the isolation of two new biphenyl derivatives, aculebiphenyls A and B (1-2), together with two known ana...
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Pyrogallol experimentally and theoretically suppressed advanced glycation end products (AGEs) formation, as one of the mechanisms involved in the chronic complications of the diabetes J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-11-25 Ashkan Dorali Beni, Seifollah Bahramikia
This study aimed to explore the inhibitory effect of pyrogallol on AGE formation in the bovine serum albumin (BSA)/glucose system for 21 days at 37 °C. The AGEs formation was measured in terms of A...
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Practical gram-scale synthesis of bicyclol metabolites M2 and M3 J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-11-07 Bo Ma, Zhen-Wei Wang, Xiao-Yu Liu, Mi-Juan Wang, Yong-Wang Zhang, Meng Zhang, Xiao-Zhen Jiao, Ping Xie
Bicyclol, an innovative hepatoprotective drug, was approved by the Chinese National Medical Products Administration (NMPA) in 2001 to treat Hepatitis B and drug-induced liver injury. Two active met...
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Pharmacokinetics of cyanidin-3-O-galactoside and cyanidin-3-O-arabinoside after intravenous administration in rats J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-11-11 Yan Chen, Jing Zhao, Han-Han Li, Wen Qian, Bing-Yu Zhou, Chang-Qing Yang
Cyanidin-3-O-galactoside and cyanidin-3-O-arabinoside (purity >98%) were isolated from black chokeberry by preparative high-performance liquid chromatography, and an animal experiment was conducted...
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Two highly conjugated ergosterols from the fungus Psathyrella rogueiana and their anti-inflammatory activity J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-11-10 Tao Feng, Wang-Qiu Deng, Ji-Kai Liu
Two previously undescribed ergosterols containing a highly conjugated ring system, psathrosterols A and B (1 and 2), have been isolated from the fungus Psathyrella rogueiana. Their structures with ...
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Four new alkaloids from the roots of Dactylicapnos scandens J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-10-31 Qian Wu, Ruo-Xi Hu, Yan-Ru Han, Qian Zhu, Wan-Jin Zhang, Juan Chen, Fan Zhang, Chun-Lei Zhang, Zheng-Yu Cao
Four new alkaloids (1 − 4), together with five known ones (5 − 9), were isolated from the bulbs of Dactylicapnos scandens. The structures were determined by analysis of their spectroscopic data and...
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Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-10-27 Yin-Yuan Wang, Jian-Cheng Ni, Yue-Qin Zhao, Xu Yang, Zhen-Peng Niu, Xing-Zhi Yang, Xian-Xiang Dong, Yu-Han Zhao, Xiao-Jiang Hao, Xiao Ding
Morinda officinalis is a traditional Chinese tonic herb, and have been used in the treatment of multiple diseases. Here, three iridoid glycosides isolated from M. officinalis were evaluated for the...
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Minor alkaloids from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-10-27 Qing Zhang, Xiao-Qiang Lei, Fang-Ting Wei, Jin-Qiu Ren, Jian-Gong Shi, Qing-Lan Guo
Seven new monoterpene alkaloids (1 − 7), along with 16 known analogues, were isolated from an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (Gou-teng). Their structures were ...
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Two new baccharane triterpenes isolated from Rhus chinensis J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-10-26 Hong-Qing Wang, Sheng-Tian Lai, Jian-Bo Liu, Hong-Jie Shao, Ruo-Yun Chen, Jie Kang
Two new baccharane triterpenes, 17,24-epoxy-23-en-baccharan-3-one (1) and 17,24(S)-epoxy-25-en-21-hydroxy-baccharan-3-one (2) were isolated from Rhus chinensis Mill. The structures were established...
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Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum: in vitro assessments by molecular docking and molecular dynamics simulations J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-10-27 Ngo Viet Duc, Vu Thi Trang, Hoang Le Tuan Anh, Le Ba Vinh, Nguyen Viet Phong, Tran Quang Thuan, Ngo Van Hieu, Nguyen Tien Dat, Le Van Nhan, Do Thanh Tuan, Le Tuan Anh, Do Thi Thao, Bui Huu Tai, Nguyen Cao Cuong, Le Quynh Lien, Seo Young Yang
Alkaloids are among the most important and best-known secondary metabolites as sources of new drugs from medicinal plants and marine organisms. A phytochemical investigation of the whole plant of C...
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Celochalcoside, a new quinochalcone C-glycoside from Celosia trigyna J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-10-16 Samy K. El-Desouky
A new quinochalcone C-glycoside featuring a unique quinonoid moiety, named celochalcoside (1), was isolated from the n-butanol extract of the aerial parts of Celosia trigyna L. The structure was de...
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Three new phenylpropanoid glucosides and a new tyramine-type alkamide from Piper puberulum J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-10-09 Hao Su, Ya-Jie Hu, Xiao-Yu Mo, Ning Diao, Yan Wang, Dong Liang
Three new phenylpropanoid glycosides, piperpubelide (1), 1-propionyl-3-hydroxy-phenyl-4-O-β-D-glucopyranoside (2), and 1-propionyl-4-hydroxy-phenyl-3-O-β-D-glucopyranoside (3), a new tyramine-type ...
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Antibacterial lanostane triterpenoids from Ganoderma tsugae J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-10-05 Jiang Hu, Guo-Fen Li, Feng-Ming Xu, Qiang Li, Tao Lv, Tian-Feng Peng, Si Yin, Wei Gong
A phytochemical investigation on the 80% EtOH extract of the fruiting bodies of Ganoderma tsugae resulted into the isolation of two previously undescribed lanostane triterpenoids, 7,11-dioxo-3β-ace...
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Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-10-05 Fatin Farhana Baharuddin, Nadiah Mad Nasir, Bimo Ario Tejo, Soo Peng Koh, Shuruti Ramakrishnan, Nur Qurratu Ain A. Nordin, Anis Nasuha Adzahar, Pavithren Devakrishnan, Salsabiilaa Mohd Razib
Tyrosinase inhibitors can reduce melanin production for skin whitening, but some existing products may harm the skin. This study discovered six compounds that inhibit tyrosinase in the mushroom Aga...
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Cordycepin, a bioactive compound from Cordyceps spp., moderates Alzheimer’s disease-associated pathology via anti-oxidative stress and autophagy activation J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-09-21 Natchadaporn Soraksa, Nudjanad Heebkaew, Wilasinee Promjantuek, Phongsakorn Kunhorm, Palakorn Kaokean, Nipha Chaicharoenaudomung, Parinya Noisa
Alzheimer’s causes cognitive dysfunction. This study investigated the neuro-promoting effects of cordycepin on amyloid-beta precursor protein (APP) synthesis in human neuroblastoma SH-SY5Y cells. C...
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Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp. J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-09-15 Hui-Min Wen, Ya-Wen Zhang, Fang-Jian Feng, Guo-Bao Huang, Yu-Han Lv, Zou-Yan Zhang, Li-Jian Ding
Abstract Two oxygenated ergostane-type steroids including one new compound, 3β-hydroxy-5α,6β-methoxyergosta-7,22-dien-15-one (1) along with a known analogue ergosta-6,22-dien-3β,5α,8α-triol (2) were isolated from the crude extracts of the marine sponge-derived fungus Aspergillus sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound 1 was a marine ergostane-type
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Biotransformation of antioxidant eriocitrin into characteristic metabolites by the gut microbiota J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-09-13 Hao-jian Zhang, Hang Yu, Jie Fu, Adili Keranmu, Zheng-Wei Zhang, Hui Xu, Jia-Chun Hu, Jin-Yue Lu, Xin-Yu Yang, Meng-Meng Bu, Zhao Zhai, Jing-yue Wang, Jian-Dong Jiang, Yan Wang
Abstract Eriocitrin is a flavonoid glycoside with strong antioxidant capacity that has a variety of pharmacological activities, such as hypolipidemic, anticancer and anti-inflammatory effects. We found that the gut microbiota could rapidly metabolize eriocitrin. By using LC/MSn-IT-TOF, we identified three metabolites of eriocitrin metabolized in the intestinal microbiota: eriodictyol-7-O-glucoside
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Structure elucidation and NMR spectral assignments of one new dammarane-type triterpenoid saponin from black ginseng J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-09-08 Xue-Ting Zhao, De-Qiang Dou, Yang Qu, Guo-Gang Zhang
Abstract New dammarane-type triterpenoid saponin, named 22(R)-notoginsenoside Ab1 (1), together with thirteen known dammarane-type triterpenoid saponins (2-14) was isolated from the EtOH extract of black ginseng and their structures were elucidated on the basis of one- and two-dimensional NMR (including 1H-NMR, 13C-NMR, HSQC, HMBC, ROESY) and calculated ECD. Among them, compounds 1-2 and 6-8 were isolated
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A review on marine source as anticancer agents J. Asian Nat. Prod. Res. (IF 1.7) Pub Date : 2023-09-07 Tamanna Rai, Niranjan Kaushik, Rishabha Malviya, Pramod Kumar Sharma
Abstract This review investigates the potential of natural compounds obtained from marine sources for the treatment of cancer. The oceans are believed to contain physiologically active compounds, such as alkaloids, nucleosides, macrolides, and polyketides, which have shown promising effects in slowing human tumor cells both in vivo and in vitro. Various marine species, including algae, mollusks, actinomycetes