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  • Chemical constituents and absolute configuration of megastigmanes’ isolated from Sedum sarmentosum Bunge
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-20
    Dinh Xuan Doan; Sijia Sun; Ashraf M. Omar; Dong Thuong Nguyen; Anh Le Tuan Hoang; Hironori Fujiwara; Kinzo Matsumoto; Hang Thi Nguyet Pham; Suresh Awale

    Abstract Phytochemical investigation of a methanolic extract of Sedum sarmentosum collected from Vietnam resulted in the isolation of a new megastigmane glucoside, named sedumoside K (1), together with 17 previously reported compounds (2–18). Structural elucidation of the new compound was achieved by HRFABMS, NMR spectroscopic analysis, acid hydrolysis and quantum ECD calculations. The absolute configuration

    更新日期:2020-10-20
  • Synthesis and biological evaluation of camptothecin substituted norcantharimide derivatives
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-20
    Qing Lan; Yiqi Zhou; Xianheng Wang; Yuhe Wang; Changkuo Zhao

    Abstract In this paper, a series of novel derivatives of camptothecin substituted norcantharimide was designed by mimic strategy. These compounds were synthesized in moderate yields by directly coupling CPT with N-amino acid norcantharimides. Their cytotoxicity to four human tumour cell lines (HepG2, BGC-803, SW480 and PANC-1) and normal human cell lines L-O2 and HIEC was evaluated. The synthesized

    更新日期:2020-10-20
  • Synthesis and insecticidal activity of the fluorinated galegine analogues
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-20
    Qinglai Wu; Jinlong Cai; Fenghai Zhao; Ziyuan Zhou; Dongyan Yang; Zhaohai Qin

    Abstract The introduction of fluorine atom can increase the biological activities of the target compounds remarkably. To find more safe and efficient insecticides, natural product galegine as lead compound, a series of novel fluorinated galegine analogues were designed and synthesized. The bioassay results indicate that all the target compounds have moderate to high insecticidal activities against

    更新日期:2020-10-20
  • Phenolic glycosides from Oroxylum indicum
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-20
    Le Thi Vien; Tran Thi Hong Hanh; Tran Hong Quang; Nguyen The Cuong; Nguyen Xuan Cuong; Hyuncheol Oh; Nguyen Van Sinh; Nguyen Hoai Nam; Chau Van Minh

    Abstract Two new phenolic glycosides, oroxylumosides A (1) and B (2), along with four known compounds darendoside A (3), leucosceptoside A (4), acteoside (5) and decaffeoylacteoside (6) were isolated from the stem bark of Oroxylum indicum. Their structures were elucidated by extensive analysis of the 1 D and 2 D NMR as well as HR-ESI-QTOF-MS. In addition, compounds 1 − 4 exhibited inhibitory effects

    更新日期:2020-10-20
  • A chemometric assessment and profiling of the essential oils from Hibiscus sabdariffa L. from Kurdistan, Iraq
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-16
    Mohammed Farhad Ibrahim; Francesco Saverio Robustelli della Cuna; Carla Villa; Marco Corti; Hawraz Ibrahim M. Amin; Pawan Faris; Pietro Grisoli; Gloria Brusotti

    Abstract Hibiscus sabdariffa L. is a tropical plant belonging to the Malvaceae family. In Kurdistan, the Autonomous Region of Iraq, water infusion of H. sabdariffa calyces is recommended for the treatment of hypotension and the common cold. Three distillation techniques: hydrodistillation (HD), steam distillation (SD), and solvent-free microwave-assisted extraction (SFME) have been compared to obtain

    更新日期:2020-10-17
  • Effect of monoterpene ester from Blumea axillaris (Lam.) DC and its acetyl derivative against plant pathogenic fungi and their in silico molecular docking
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-16
    Subramaniyan Sivanandhan; Ganesan Pathalam; Stalin Antony; Gabriel Paulraj Michael; Kedike Balakrishna; Ahilan Boovaragamurthy; Osamu Shirota; Mona S Alwahibi; Mohamed Soliman El-Shikh; Savarimuthu Ignacimuthu

    Abstract The present study was aimed to isolate active constituents from Blumea axillaris (Lam.) DC (Asteraceae) against phytopathogenic fungi. Bioactivity guided fractionation of the successive n-hexane, chloroform and methanol extract led to the isolation of the monoterpene ester (4 R,5S)-4-hydroxy-7-tigloyloxycarvotanacetone (1). The compound 1 was converted into acetyl derivative (2). The acetyl

    更新日期:2020-10-17
  • Cytotoxic triterpenoid saponins from Thalictrum atriplex
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-15
    FanCheng Meng; XiaoDong Wei; Yan Sun; QingHong Zeng; Guowei Wang; XiaoZhong Lan; ZhiHua Liao; Min Chen

    Abstract Two new cycloartane glycosides, cycloatriosides A and B (1–2), and a new oleanolic acid glycoside, thaliatrioside A (3), along with 7 known triterpenoids (4–10) were isolated from Thalictrum atriplex. The structures of the new compounds were established as 3-O-β-D-galactopyranosyl (20S, 24 R)-3β,16β,25,29-tetrahydroxy-20,24-epoxycycloartane-29-O-β-D-glucopyranoside (1), 3-O-β-D-glucopyran

    更新日期:2020-10-16
  • Cyttaria hariotii E.Fisch. as a promising source of pullulan and Mn(II)-pullulan complexes for Mn-deficiency remediation in winter cereals
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-14
    M. Carmen Ramos-Sánchez; Jesús Martín-Gil; Laura Buzón-Durán; Pablo Martín-Ramos

    Abstract Pullulan, a water-soluble polysaccharide consisting of maltotriose units used in the preparation of edible films and drug delivery, is generally produced from starch by Aureobasidium pullulans (de Bary & Löwenthal) G.Arnaud fungus. In this article, the characterisation of an alternative pullulan source − the stromata of Cyttaria hariotii E.Fisch. fungus − by elemental analysis, infrared spectroscopy

    更新日期:2020-10-15
  • Angiogenic effects of low molecular weight organic acids present in fulvic acids of different sources
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-14
    Zhi Wang; Huifen Zhang; Yi Qin; Weifeng Dai; Baocai Li; Mi Zhang

    Abstract Fulvic acid (FA) is a natural mineral medicine with a long medical history in folk. However, the active chemicals of FA remain unknown due to its diversity of sources and the complexity of compositions, which have become a bottleneck in quality control and medicinal development. Based on the traditional effect on angiogenesis, FAs from eight different coal sources were prepared and their active

    更新日期:2020-10-15
  • Secoiridoid glycosides from the fruits of Cornus officinalis
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-14
    Xin Wang; Xiang-Jian Zhong; Na Zhou; Lin-Lin Ji; Jin-Jie Li; Ning Cai; Qing-Bo Wang; Peng-Cheng Lin; Xiao-Ya Shang

    Abstract Five new secoiridoid glycosides, cornusphenosides E-I (1–5), were isolated and characterized from an active fraction of ethanol extract of the fruits of Cornus officinalis. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound 5 (when evaluated at 10 μM) showed the neuroprotective effect against

    更新日期:2020-10-15
  • The in vitro and in vivo anti-inflammatory activities of triterpene saponins from Clematis florida
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-14
    Na-Na Yang; Yi-Fan Zhang; Hai-Tao Zhang; Xin-Hua Ma; Jin-Huang Shen; Peng Li; Tian-Hua Zhong; Yong-Hong Zhang

    Abstract Clematis florida is widely used in She Ethnopharmacy in China owing to its significant anti-inflammatory activities. This study aimed to investigate the anti-inflammatory effect of the active fraction of C. florida (CFAF) in an arthritis animal model and its possible mechanism. Pre-inflammatory cytokine levels were examined by ELISA. CFAF can significantly improve the symptoms of arthritis

    更新日期:2020-10-15
  • Polyacetylene and phenolic constituents from the roots of Codonopsis javanica
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-14
    Nguyen Huu Toan Phan; Nguyen Thi Dieu Thuan; Nguyen Thi Thu Hien; Pham Van Huyen; Nguyen Huu Huong Duyen; Tran Thi Hong Hanh; Nguyen Xuan Cuong; Tran Hong Quang; Nguyen Hoai Nam; Chau Van Minh

    Abstract Chemical investigation of the roots of Codonopsis javanica resulted in isolation of 12 compounds, including one new polyacetylene, codojavanyol (1), one new phenolic glycoside, codobenzyloside (7), and 10 known compounds, (2E,8E)-9-(tetrahydro-2H-pyran-2-yl)nona-2,8-diene-4,6-diyl-1-ol (2), lobetyol (3), lobetyolin (4), lobetyolinin (5), cordifolioidyne B (6), benzyl-α-L-arabinopyranosyl

    更新日期:2020-10-15
  • Catechin from Burkea africana Hook. Exhibits in vitro inhibition of human telomerase activity
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-14
    Okwuchukwu Kodichinma Eboji; Gustavo Borges; Lea Harrington; Wenhan Lin; Margaret Oluwatoyin Sofidiya; Abimbola Adepeju Sowemimo

    Abstract There has been an increasing interest in natural products with the ability to inhibit telomerase activity in tumour and cancerous cells. Green tea catechins have been reported previously to inhibit telomerase, but it was unknown whether catechins from other plant sources could exhibit this property. We isolated 2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol (catechin without the

    更新日期:2020-10-15
  • Cytotoxic effect of pure compounds from Piper rivinoides Kunth against oral squamous cell carcinoma
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-14
    Anna Carolina Carvalho da Fonseca; Lucas Nicolau de Queiroz; Jessica Sales Felisberto; Ygor Jessé Ramos; André Mesquita Marques; Guilherme Freimann Wermelinger; Bruno Pontes; Davyson de Lima Moreira; Bruno Kaufmann Robbs

    Abstract The oral squamous cell carcinoma (OSCC) is the eighth more common cancer in men. The development of new and more efficient drugs is needed. Plants of the genus Piper are popularly used in the treatment of many diseases. This study evaluated the antitumor effect of extract, fraction and isolated compounds from leaves of P. rivinoides in oral cancer. The isolated compounds (conocarpan, eupomatenoid-5

    更新日期:2020-10-15
  • Essential oils from leaves of Vernonanthura montevidensis (Spreng.) H. Rob.: chemical profile and antimollicute potential
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-14
    Ricardo Andrade Rebelo; Tiago Tizziani; Iêda Maria Begnini; Ilene Crestani; Jocinei Dognini; André Luiz de Gasper; Caio Maurício Mendes de Cordova; Larissa dos Santos; Sabrina Hochheim; Nicolas Baldovini

    Abstract Aiming to valorise the Atlantic Rainforest biodiversity in Santa Catarina, the chemical characterisation of the essential oils (EOs) from leaves of Vernonanthura montevidensis (Spreng.) H. Rob. is described for the first time. Fresh leaves collected in the year 2014 and 2015, were submitted to hydrodistillation to give pale blue EOs in yields of 0.21 and 0.19%, respectively. The EOs were characterised

    更新日期:2020-10-15
  • Metabolomic profiling and antioxidant potential of three fungal endophytes derived from Artemisia annua and Medicago sativa
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-12
    Ahmed M. Sayed; Noheir H. Sherif; Ahmed O. El-Gendy; Yara I. Shamikh; Asmaa T. Ali; Eman Zekry Attia; Mo'men H. El-Katatny; Basma Ali Khalifa; Hossam M. Hassan; Usama Ramadan Abdelmohsen

    Abstract In this work, three fungal endophytes identified as Aspergillus terreus (AFL, AFSt and AFR), were studied for their antioxidant potential. LC-MS-based metabolomics, followed by multivariate statistical analysis were then applied to comprehensively profile their extracts. The three fungal endophytes revealed interesting antioxidant potential, in particular, the strain isolated from the Artemisia

    更新日期:2020-10-12
  • Four new triterpene glucosides from Salacia cochinchinensis Lour
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-12
    Lu Gao; Li-Kun Duan; Jin-E Feng; Yun-Tao Jiang; Jun Gao; Jun-Ting Fan; Rong Dai; Zhi-Yong Jiang

    Abstract Four new triterpene glucosides (1–4) were isolated from the 90% ethanol extract of Salacia cochinchinensis, together with five known compounds (5–9). The structures of the new compounds were elucidated by comprehensive spectroscopic analysis including HRESIMS, IR, 1 D and 2 D NMR analysis. All isolates were assayed for their α-glucosidase inhibitory activity. Compound 9 showed remarkable α-glucosidase

    更新日期:2020-10-12
  • Conversion of methyl carlactonoate to heliolactone in sunflower
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-09
    Takatoshi Wakabayashi; Hikaru Shinde; Nanami Shiotani; Shunya Yamamoto; Masaharu Mizutani; Hirosato Takikawa; Yukihiro Sugimoto

    Abstract Heliolactone is a non-canonical strigolactone isolated from sunflower root exudates. We have previously demonstrated that exogenously administered carlactonoic acid (CLA) was converted to heliolactone in sunflower. The conversion of CLA to heliolactone requires the methyl esterification of the carboxylic acid at C-19. Also, the CLA conversion to its methyl ester, methyl carlactonoate (MeCLA)

    更新日期:2020-10-11
  • A new depsidone from the lichen Usnea ceratina Arch
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-09
    Van-Muoi Bui; Thuc-Huy Duong; Warinthorn Chavasiri; Kim-Phi-Phung Nguyen; Bui-Linh-Chi Huynh

    Abstract Chemical investigation of the lichen Usnea ceratina Arch led to the isolation of five depsidones, including one new compound ceratinalone (1) along with four known compounds bailesidone (2), stictic acid (3), 8′-O-methylstictic acid (4) and 8′-O-ethylstictic acid (5). The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. Compounds

    更新日期:2020-10-11
  • Total alkaloids from the rhizomes of Ligusticum striatum: a review of chemical analysis and pharmacological activities
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-09
    Zhong-Hui Pu; Min Dai; Liang Xiong; Cheng Peng

    Abstract Rhizome Chuanxiong (RCX), the dried rhizomes of Ligusticum striatum DC., is a geoauthentic TCM herb distributed in Sichuan province of China that possesses efficacy in promoting blood circulation, removing blood stasis and alleviating pain. Rhizome Chuanxiong total alkaloids (RCXTAs) are one of the major characteristic constituents of RCX with the effects of antimigraine, neuroprotective,

    更新日期:2020-10-11
  • Chemical composition and chemotaxonomy of Nasutitermes spp. defensive secretion from Brazilian Cerrado for the differentiation of species
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-09
    Jerônimo Raimundo Oliveira-Neto; Naiara Raica Lopes de Oliveira; Alessandro de Carvalho Cruz; Pedro Henrique Ferri; Neucírio Ricardo de Azevedo

    Abstract Nasutitermes spp. soldier defensive secretion has a toxic and repellent effect against predators. Chemical profile characterization of this secretion is an interesting tool to differentiate similar termite species. This study aimed to determine defensive secretion composition of Nasutitermes spp. soldier and to apply chemotaxonomy tool for the unambiguous species identification. Fifteen volatile

    更新日期:2020-10-11
  • Diffusosides C and D, two new iridoid glucosides from Oldenlandia diffusa
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-09
    Yongyong Zhang; Huiping Hu; Jiabo Luo

    Abstract During our continual investigations on Oldenlandia diffusa (Willd.) Roxb., two new iridoid glucosides, diffusosides C (1) and D (2), were isolated and their structures were elucidated through cumulative analysis of NMR and HRESIMS spectroscopic data as well as computational studies. Both isolated compounds displayed no obvious neuroprotective activity on H2O2-induced injury PC12 cells at 50 μM

    更新日期:2020-10-11
  • Biological effect of astaxanthin on alcohol-induced gut damage in Carassius auratus used as experimental model
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-09
    Alesci Alessio; S. Pergolizzi; T. Gervasi; M. Aragona; P. Lo Cascio; N. Cicero; E. R. Lauriano

    Abstract Alcohol and its metabolites are responsible for damage both within the gastrointestinal tract and other organs. Alcohol abuse promote intestinal inflammation, that may be the cause of multiple organ dysfunctions and chronic disorders. In this research, the effect of astaxanthin, a powerful antioxidant with several biological effects, on alcohol damage-induced in the intestine of Carassius

    更新日期:2020-10-11
  • Chemical constituents and their antioxidant activities from the leaves of Synsepalum dulcificum
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-09
    Junfei Wang; Shicheng Shao; Rong Huang; Shaohua Wu

    Abstract Synsepalum dulcifificum is an evergreen shrub native of tropical West Africa. It is very effective against a variety of diseases. However, the phytochemical investigation on this plant is limited till now. In our current study, seventeen compounds were isolated and identified from the ethyl acetate extract of the leaves. All of the compounds were obtained from S. dulcifificum for the first

    更新日期:2020-10-11
  • Synthesis of eugenol-derived glucosides and evaluation of their ability in inhibiting the angiotensin converting enzyme
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-09
    Dalila Junqueira Alvarenga; Laira Maria Faria Matias; Cleydson Finotti Cordeiro; Thiago Belarmino de Souza; Stefânia Neiva Lavorato; Marília Gabriella Alves Goulart Pereira; Danielle Ferreira Dias; Diogo Teixeira Carvalho

    Abstract We report here a series of glucosides which are active as inhibitors of the angiotensin converting enzyme (ACE). They are structurally related to the natural compound eugenol and exhibited significant inhibition values. Their syntheses were expeditious and we could obtain informative docking plots of them complexed to this enzyme. A glucoside derived from eugenol, carrying a carboxylic group

    更新日期:2020-10-11
  • Antileishmanial activity of the essential oils of Myrcia ovata Cambess. and Eremanthus erythropappus (DC) McLeisch leads to parasite mitochondrial damage
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-08
    Geovany Amorim Gomes; Karina Martins-Cardoso; Frances Regiane dos Santos; Melissa Florencio; Dayana Rosa; Aline Araujo Zuma; Gilvandete Maria Pinheiro Santiago; Maria Cristina M. Motta; Mario Geraldo de Carvalho; Patrícia Fampa

    Abstract Leishmania amazonensis is a species causative of cutaneous and anergic diffuse cutaneous leishmaniasis, treatment-resistant form, in the New World. Plants essential oils exhibit great potential as microbicide agents. We described the composition of the essential oils of two plants native from Brazil, Myrcia ovata, with geranial and neral as major constituents, and Eremanthus erythropappus

    更新日期:2020-10-08
  • Natural products in diabetes research: quantitative literature analysis
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-07
    Andy Wai Kan Yeung; Nikolay T. Tzvetkov; Alessandra Durazzo; Massimo Lucarini; Eliana B. Souto; Antonello Santini; Ren-You Gan; Artur Jozwik; Weronika Grzybek; Jarosław O. Horbańczuk; Andrei Mocan; Javier Echeverría; Dongdong Wang; Atanas G. Atanasov

    Abstract The current study aimed to identify which natural products and which research directions are related to the major contributors to academic journals for diabetes therapy. Bibliometric data were extracted from the Web of Science online database using the search string TOPIC = (‘‘natural product*’ OR ‘‘natural compound*’ OR ‘‘natural molecule*’ OR ‘phytochemical*’ OR ‘‘secondary metabolite*’)

    更新日期:2020-10-07
  • Antiestrogenic and antiproliferative potency of secoisolariciresinol diglucoside derivatives on MCF-7 breast cancer cells
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-07
    Alexander M. Scherbakov; Olga V. Stasevich; Diana I. Salnikova; Olga E. Andreeva; Ekaterina I. Mikhaevich

    Abstract Secoisolariciresinol diglucoside (SDG) is isolated from Linum usitatissimum seeds. The antiproliferative effects of SDG (1) and its derivatives secoisolariciresinol (2) and secoisolariciresinol-4′, 4″-diacetate (3) have been evaluated on MCF-7 breast cancer cells and normal breast epithelial line MCF-10A. Lignan 1 has not shown cytotoxic effects on MCF-7 cells, while derivatives 2 and 3 have

    更新日期:2020-10-07
  • Neuroactivity of the naturally occurring aporphine alkaloid, roemerine
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-07
    Omer Bayazeid; Emirhan Nemutlu; Cemil Can Eylem; Mert İlhan; Esra Küpeli-Akkol; Hande Karahan; Pelin Kelicen-Uğur; Tayfun Ersoz; Funda N. Yalçın

    Abstract Roemerine is a naturally occurring aporphine alkaloid. In this study, we screened a conformer library of Food and Drug Administration (FDA)-approved drugs to identify similar drugs that can assist in identifying the biological targets of roemerine. To assess the neuroactivity in vitro, we measured the levels of cell metabolites, Brain-Derived Neurotrophic Factor (BDNF) and serotonin (5-HT)

    更新日期:2020-10-07
  • Calamusins J-K: new anti-angiogenic sesquiterpenes from Sarcophyton glaucum
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-05
    Mohamed Shaaban; Faten Y Yassin; Maha M Soltan

    Abstract Chemical investigation of the organic extract of the marine soft coral Sarcophyton glaucum from Red Sea, Egypt, afforded two new hydroazulenes; calamusin J (1) and its hydroperoxide derivative calamusin K (2) in addition to eight known compounds. Structure of compounds 1-2 were confirmed by intensive NMR and mass spectrometry studies. The coral extract and the obtained compounds were examined

    更新日期:2020-10-06
  • Phytotoxic metabolites from Stilbocrea macrostoma, a fungal pathogen of Quercus brantii in Iran
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-05
    Roberta Di Lecce; Samaneh Bashiri; Marco Masi; Daniela Alioto; Angela Tuzi; Jafar Abdollahzadeh; Antonio Evidente

    Abstract Two phytotoxic furan derivatives were isolated, together with the well-known fungal and plant phytotoxin tyrosol, from the culture filtrates of Stilbocrea macrostoma. This fungal pathogen isolated from Quercus brantii trees induced wood necrosis and decline symptoms on the host plant in Iran. The two furan derivatives, isolated for the first time from Stilbocrea macrostoma, were identified

    更新日期:2020-10-05
  • Adiantic acid, a new unsaturated fatty acid with a cyclopropane moiety from Adiantum flabellulatum L.
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-05
    Junping Chen; Yichen Li; Jianguo Cao; Jinwen Huang; Can Jiang; Xiling Dai; Guozheng Huang

    Abstract Phytochemical investigation of Adiantum flabellulatum L. led to the isolation of four natural compounds, including a novel unsaturated fatty acid with a cyclopropane moiety, i.e. (S,E)-7-(2-octylcyclopropylidene)heptanoic acid (1), together with three known compounds, isoadiantol B (2), stigmast-4-en-6β-ol-3-one (3), β-sitosterol (4). Compound 3 was isolated from the A. flabellulatum L. for

    更新日期:2020-10-05
  • Cytotoxic xanthones from the plant endophytic fungus Paecilamyces sp. TE-540
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-04
    Xiu-Qi Li; Quan-Jiang Dong; Kuo Xu; Xiao-Long Yuan; Xin-Min Liu; Peng Zhang

    Abstract One new xanthone, chryxanthone C (1), together with four known analogues (2−5), were isolated from the cultures of Paecilamyces sp. TE-540, an endophytic fungus obtained from the leaves of Nicotiana tabacum L. The structure of 1 was elucidated by comprehensive spectral analysis including HRESIMS and 1D/2D NMR, which were confirmed by Cu Kα X-ray crystallography. Compound 1 featured an unusual

    更新日期:2020-10-05
  • One new piperazinedione isolated from a mangrove-derived fungus Aspergillus niger JX-5
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-04
    Meng Bai; Yue Wang; Ting Liu; Yu-Xing Lian; Qi-Qi Bai; Xiao-Ping Song; Chang-Ri Han; Cai-Juan Zheng; Guang-Ying Chen

    Abstract One new piperazinedione derivative, nigerpiperazine A (1), along with six known compounds (2–7) were isolated from the fungus Aspergillus niger JX-5 from mangrove Ceriops tagal. Nigerpiperazine A (1) was elucidated by spectroscopic analyses and 13C NMR chemical shift calculations, compounds 4 and 5 were determined by X-ray and the CD spectra. The absolute configuration of 4 was identified

    更新日期:2020-10-05
  • A new cytotoxic indole alkaloid from the fungus Penicillium polonicum TY12
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-04
    Xue-Yun Cai; Jia-Peng Wang; Yan Shu; Jun-Tao Hu; Cheng-Tong Sun; Le Cai; Zhong-Tao Ding

    Abstract A new dimeric monoterpene indole alkaloid polonidine A (1), along with five known compounds, cyclopenol (2), verrucosidin (3), fructigenine A (4), 3-O-methylviridicatin (5) and aurantiomides C (6), were isolated from Penicillium polonicum TY12. Their structures were established on the basis of extensive spectroscopic analyses. Compound 1 exhibited moderate cytotoxic activities and moderate

    更新日期:2020-10-05
  • Bixa orellana L. by-products’ fractions from an industrial process: antiproliferative activity on tumor cells and chemical profile
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-04
    Rosanna Tarkany Basting; Pedro Manoel Barreto de Abreu; Ilza Maria de Oliveira Sousa; João Ernesto de Carvalho; Paulo Roberto Nogueira Carvalho; Mary Ann Foglio

    Abstract This study evaluated the phytochemical characterization of Bixa orellana (BO extract) unsaponifiable extract and resulting fractions (F fraction - FF, Geranyl fraction – GF and R fraction- RF) obtained as by-products of an industrial process investigating in vitro antiproliferative activities in human tumoral cells. The main compounds identified by GC-MS for BO extract were Geranylgeraniol

    更新日期:2020-10-05
  • Caracterização e identificação de constituintes químicos de Ocotea paranaensis Brotto, Baitello, Cervi, & EP Santos e suas propriedades biológicas
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-01
    Caroline Gribner; Katlin Suellen Rech; Paula Francislaine Moura; Ana Angélica Ruscheweyh Rigoni; Larissa Junqueira Gatto; Andressa Veiga; Vitor Alberto Kerber; Marilis Dallarmi Miguel; Obdulio Gomes Miguel; Josiane de Fátima Gaspari Dias

    Abstract Resumo The growing interest in the discovery of new compounds from medicinal plants justifies the study of phytochemical components of these plants and their biological activities. The genus Ocotea exhibits a variety of pharmacological, antimicrobial and antioxidant effects. The aim of the present study was to evaluate the antioxidant potential and antimicrobial properties of the ethyl acetate

    更新日期:2020-10-02
  • A new germacranolide from Ageratina vernalis
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-01
    Miguel Á. Fuentes-Figueroa; Neively Tlapale-Lara; Beatriz Hernández-Carlos; Pedro Joseph-Nathan; Eleuterio Burgueño-Tapia

    Abstract The aerial parts of Ageratina vernalis provided the new germacranolide 1,10-epoxydeltoidin A (3), together with the known pentacyclic triterpenoid hopane-6α,22-diol (1), and the also known germacranolides deltoidin A (2) and 15-hydroxydeltoidin A (4). In addition, pTsOH catalyzed cyclization of 2 afforded the new guaianolide 5. The absolute configuration of 2, 4, and 5 was assigned by vibrational

    更新日期:2020-10-02
  • Campomanesia xanthocarpa (Mart.) O. Berg essential oil induces antileishmanial activity and remodeling of the cytoplasm organelles
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-01
    Fabiana Borges Padilha Ferreira; Áquila Carolina Fernandes Herculano Ramos-Milaré; José Eduardo Gonçalves; Danielle Lazarin-Bidóia; Celso Vataru Nakamura; Rosangela Rumi Sugauara; Carla Maria Mariano Fernandez; Zilda Cristiani Gazim; Izabel Galhardo Demarchi; Thaís Gomes Verzignassi Silveira; Maria Valdrinez Campana Lonardoni

    Abstract Leishmaniasis is a neglected disease that affects millions of people worldwide. This study aimed to analyze antileishmanial activity of Campomanesia xanthocarpa leaf essential oil (EO) on promastigote and amastigote forms of Leishmania amazonensis, cytotoxicity in murine macrophages and sheep erythrocytes. The essential oil (EO) was analyzed by gas chromatography/mass spectrophotometry. The

    更新日期:2020-10-02
  • Anti-inflammatory activity of Brunfelsia uniflora root extract: phytochemical characterization and pharmacologic potential of this under-investigated species
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-01
    Patrícia Weimer; Lenise Maria Spies; Ronete Haubert; João Alfredo Santos de Lima; Rage Weidner Maluf; Rochele Cassanta Rossi; Edna Sayuri Suyenaga

    Abstract Brunfelsia uniflora (Pohl) D. Don roots have been widely used in folk medicine for treating inflammatory conditions. However, few studies have elucidated compounds that justify their traditional use. This study was conducted to characterize the phytochemical profile and evaluate the in vitro antioxidant capacity, and in vivo anti-inflammatory activity of extracts obtained from B. uniflora

    更新日期:2020-10-02
  • Synthesis, molecular docking and ADMET prediction of novel swertiamarin analogues for the restoration of type-2 diabetes: an enzyme inhibition assay
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-01
    Satyender Kumar; Prakash Niguram; Vedika Bhat; Seema Jinagal; Vinod Jairaj; Neelam Chauhan

    Abstract Swertiamarin is a lead, biologically active compound obtained from Enicostemma littorale Blume and known to be identified for the anti-diabetic activity. Present work comprises the synthesis and structural optimization of seven novel swertiamarin analogues and those were not being reported elsewhere till date. Swertiamarin was isolated, followed by modifications that have been accomplished

    更新日期:2020-10-02
  • A new benzophenone with biological activities purified from Aspergillus fumigatus SWZ01
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-10-01
    Bing Liu; Ning Chen; Ying-xiang Chen; Jie-jing Shen; Ying Xu; Yu-bin Ji

    Abstract Strain SZW01 was isolated from sea sediment collected from Shenzhen in Guangdong province, China, and was later identified as Aspergillus fumigatus by16S rDNA sequence analysis. Various chromatographic processes led to the isolation and purification of three compounds from the fermentation culture of SZW01, including a new compound, 2,6'-dihydroxy-2,4'dimethoxy-8'-methyl-6-methoxy-acyl-et

    更新日期:2020-10-02
  • Xylariaopyrones E–I, five new α-pyrone derivatives from the endophytic fungus Xylariales sp. (HM-1)
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-30
    Wen-Wen Yang; Li-Wen Lu; Xue-Qing Zhang; Shang-Song Bao; Fei Cao; Zhi-Yong Guo; Zhang-Shuang Deng; Peter Proksch

    Abstract Five new α-pyrones, xylariaopyrones E–I (1–5), along with three known analogues (6–8) were isolated from the cultivation broth of the endophytic fungus Xylariales sp. (HM-1). The structures of the new compounds including their absolute configurations were elucidated by comprehensive spectroscopic methods and quantum ECD calculations. Xylariaopyrone E (1) is the first example of α-pyrone derivative

    更新日期:2020-09-30
  • Three new p-coumaroylated sesquiterpenoids from Pilea cavaleriei
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-30
    Yong Zhou; Heng-Chun Ren; Qing-Ying Zhang; Hong Liang; Peng-Fei Tu

    Abstract Four p-coumaroylated sesquiterpenoids (1–4), including three new ones (1, 2, and 4), were isolated from the whole plants of Pilea cavaleriei. Their structures were established on the basis of comprehensive spectroscopic analysis and comparison with data reported in the literature. Compounds 1–4 were evaluated for their antimycobacterial activities, and 2 and 4 were active against Mycobacterium

    更新日期:2020-09-30
  • Polyhydroxylated steroid derivatives from the starfish Pentaceraster regulus
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-30
    Le Thi Vien; Tran Thi Hong Hanh; Tran Hong Quang; Nguyen Xuan Cuong; Do Thi Thao; Nguyen Hoai Nam; Do Cong Thung; Phan Van Kiem; Chau Van Minh

    Abstract A new polyhydroxysteroid glycoside, regulusoside D (1), and a new polyhydroxylated steroid, (24S)-cholestane-3β,5,6β,8,15α,24-hexol (2), together with seven known compounds were purified from the starfish Pentaceraster regulus collected near Con Co Islands, Vietnam. The structure elucidation was confirmed by extensive analysis of their NMR and HR-QTOF mass experiments. Among isolated compounds

    更新日期:2020-09-30
  • Anti-inflammatory xenicane-type diterpenoid from the intertidal brown seaweed Sargassum ilicifolium
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-30
    Shubhajit Dhara; Kajal Chakraborty

    Abstract Chemical analysis of the organic extract from intertidal brown seaweed Sargassum ilicifolium (family Sargassaceae) characterised an undescribed xenicane-type diterpenoid sargilicixenicane, elucidated as 3-(17-hydroxy-14-methylhept-13-en-10-yl)-6-methylhexahydro-1H-cyclonona[c]furan-4,19-diyl diacetate (compound 1). The studied compound exhibited prospective free radical quenching potential

    更新日期:2020-09-30
  • Anti-inflammatory Dendranacetylene A, a new polyacetylene glucoside from the flower of Chrysanthemum morifolium Ramat
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-29
    Meng Li; Mengnan Zeng; Jingke Zhang; Jingya Shi; Jinjin Lv; Yingying Tang; Xiao-ke Zheng; Wei-sheng Feng

    Abstract A new polyacetylene glucoside, Dendranacetylene A (1), and a known compound 8E-decaene-4,6-diyn-1-O-β-d-glucopyranosyl-(1ʺ→2ʺ)-β-d-glucopyranoside (2) were isolated from the flowers of Dendranthema morifolium (Ramat.) kitam. The chemical structures of these compounds were elucidated by NMR and HR-ESI-MS analysis, and comparing these results with data reported in literatures. Additionally,

    更新日期:2020-09-29
  • Bisbenzylisoquinoline alkaloids of Cissampelos sympodialis with antiviral activity against dengue virus
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-29
    Poliana G. da Silva; Aventino H. Fonseca; Malu P. Ribeiro; Taizia D. Silva; Cristiane F. F. Grael; Lindomar J. Pena; Tania M. S. Silva; Eduardo de J. Oliveira

    Abstract A number of bisbenzyilisoquinoline alkaloids have been previously isolated from Cissampelos sympodialis (Menispermaceae). The tertiary alkaloid fraction of the rhizomes (TAFrz) was prepared and the major alkaloid warifteine was isolated. Five TAFrz subfractions in addition to warifteine were tested against Dengue virus (DENV). We then used an epithelial (Vero) cell line to evaluate the cytotoxicity

    更新日期:2020-09-29
  • Antifeedant and ovicidal activities of a new cassane and other compounds from Caesalpinia welwitschiana Oliv. and Caesalpinia bonduc L. against Tuta absoluta (Lepidoptera: Gelechiidae)
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-28
    Flaure Rosette Ehawa Essoung; Brice Mitterant Mba’ning; Alain Tadjong Tcho; Sumesh Chander Chhabra; Samira Abuelgasim Mohamed; Bruno Ndjakou Lenta; Silvere Augustin Ngouela; Etienne Tsamo; Ahmed Hassanali; Russell John Cox

    Abstract Methanolic extracts of liana of Caesalpinia welwitschiana and leaves of C. bonduc were found to possess moderate antifeedant and ovicidal activities against Tuta absoluta. Bioassay-guided isolation of constituents from the most active fraction of C. welwitschiana led to the identification of four known compounds [isobonducellin 1a and bonducellin 1 b, intricatinol 2, (-)-epigallocatechin-3-O-gallate

    更新日期:2020-09-28
  • Manniindole, an indole derivative from the roots of Anonidium mannii and combined antischistosomal and enzymatic activities
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-28
    Josette Linda Toussi Matchi; Diderot Tchamo Noungoue; Isabelle Kuhn; Jérôme Boissier; Jean Claude Tchouankeu; Marc Nothisen; Guilhem Chaubet; Delphine Garnier; Sylvain Ursuegui; Silvère Augustin Ngouela; Alain Wagner

    Abstract A new alkaloid, manniindole 1, together with four known compounds: aristolactam AII 2, aristolactam BII 3, piperolactam D 4 and polycarpol 5 were isolated from the crude extract EtOH-H2O (8:2) of the roots of Anonidium mannii by chromatographic separation. The structure elucidation was performed on the basis of a spectroscopic analysis (IR, HRESI MS, 1D and 2D NMR) as well as a comparison

    更新日期:2020-09-28
  • Hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis Fisch in liver injury mice
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-28
    San-hu Gou; Miao He; Bei-bei Li; Ning-yi Zhu; Jing-man Ni

    Abstract This work aimed to investigate the hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis. The main compounds in licorice total flavonoids (LTF) were isolated from Glycyrrhiza uralensis and their total content in LTF were more than 60%. Hepatoprotective effects of LTF were investigated in three kinds of hepatic injury mice model induced by high-fat emulsion, Chinese liquor

    更新日期:2020-09-28
  • The impact that β-citronellol isomers have on the biofilm formation of Candida yeasts
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-25
    Daniele de Figueredo Silva; Laísa Vilar Cordeiro; Pedro Thiago Ramalho Figueiredo; Hermes Diniz-Neto; Helivaldo Diógenes da Silva Souza; Edeltrudes de Oliveira Lima

    Infections associated with biofilms developed by Candida spp. are becoming a great problem due to its resistance against the immune response of the host and the action of antifungal agents. Hence, finding substances that can inhibit the development of biofilms increases the likelihood that these compounds one day can become good antifungals applied in the clinic. The aim of this study was to evaluate

    更新日期:2020-09-25
  • A new depside and a new secoiridoid from the aerial parts of Gentiana olivieri from flora of Turkey
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-25
    Hasan Kırmızıbekmez; Deniz Tatar; Murat Erdoğan; Norbert Kúsz; Judit Hohmann

    A new depside, olivieridepside (1), and a new secoiridoid, olivierigenin (2) were isolated from the aerial parts of Gentiana olivieri Griseb. along with four known compounds, gentiopicroside (3), olivierosides A (4) and B (5) and isoorientin (6). The structures of the isolates were determined by extensive 1 D and 2 D NMR spectroscopy and HR-MS analysis. This is the first report on the occurrence of

    更新日期:2020-09-25
  • Cytotoxic potential of the Red Sea sponge Amphimedon sp. supported by in silico modelling and dereplication analysis
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-25
    Nourhan Hisham Shady; Usama Ramadan Abdelmohsen; Asmaa M. AboulMagd; Mohamed N. Amin; Safwat Ahmed; Mostafa A. Fouad; Mohamed Salah Kamel

    The chemical profile of the butanol fraction of the Red Sea sponge Amphimedon sp. was explored using liquid chromatography coupled with high-resolution mass spectrometry and identified compounds (1–11). Moreover, cytotoxic activities of the total extract and other fractions were examined against three cell lines HEPG2, MCF7 and CACO2, revealed the powerful effect of the total extract and the butanol

    更新日期:2020-09-25
  • Essential oil composition of Salvia rosmarinus spenn. wild samples collected from six sites and different seasonal periods in Elba Island (Tuscan Archipelago, Italy)
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-25
    Guido Flamini; Basma Najar; Michele Leonardi; Katarzyna E. Ambryszewska; Pier Luigi Cioni; Federico Parri; Bernardo Melai; Luisa Pistelli

    The hydrodistilled essential oils from eighteen samples of Salvia rosmarinus Spenn. collected in six localities of Elba Island (Tuscany, Italy) during three different seasonal periods were analyzed by GC-MS for the first time. Fifty-five components were identified, representing 96.8–99.6% of the total chemical composition. All the tested essential oils were characterized by a high content of monoterpenes

    更新日期:2020-09-25
  • Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV)
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-25
    Giuseppina Sanna; Silvia Madeddu; Gabriele Serreli; Hoai Thi Nguyen; Nhan Trong Le; Donatella Usai; Antonio Carta; Piero Cappuccinelli; Stefania Zanetti; Matthew Gavino Donadu

    In the prevention of epidemic and pandemic emerging and neglected viral infections, natural products are an important source of lead compounds. Hornstedtia bella Škorničkis is a rhizomatous herb growing in the forest of central Vietnam. Hornstedtia bella essential oil (Hb EO) was recently characterised by our group as endowed of antimicrobial activity against Staphylococcus aureus Methicillin-Resistant

    更新日期:2020-09-25
  • A new sesquiterpene from mangrove endophytic fungus Aspergillus sp. GXNU-MA1.
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-23
    Dexiong Zhou,Wenxiu Zhang,Lili Hao,Xiaoya Qin,Ruiyun Yang,Jun Li,Xishan Huang

    A new sesquiterpene, gxsespene A (1), and four known sesquiterpene derivatives 2–5 were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-MA1. Their structures were elucidated based on high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of 1

    更新日期:2020-09-23
  • A novel alkaloid from the seeds of Sophora alopecuroides L.
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-23
    Zi-Jian Rong,Xiao-Xu Gao,Gao-Sheng Hu,Ting Yan,Jing-Ming Jia,An-Hua Wang

    A new cytisine-type alkaloid, along with five known alkaloids was obtained from the seeds of Sophora alopecuroides. Their structures were determined to be (−)-N-(2'-hydroxy-3',5'-di-tert-butyl-toluene)-cytisine (1), (−)-lupanine (2), (+)-matrine (3), (+)-sophoramine (4), (+)-lehmannine (5) and (−)-sophocarpine (6). Their structures were established by NMR, ECD and HRESIMS data analyses. Their cytotoxicity

    更新日期:2020-09-23
  • A new ent-abietane lactone from Glycosmis pentaphylla.
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-23
    Suwadee Chokchaisiri,Nuttapon Apiratikul,Thitima Rukachaisirikul

    A new ent-abietane lactone, 3-oxojolkinolide A (1), together with 16 known compounds, helioscopinolide E (2), helioscopinolide A (3), 3-methyl-9H-carbazole (4), carbalexin (5), carbalexin B (6), glycaborinine (7), arborinine (8), 1H-indole-3-carbaldehyde (9), glycoamide A (10), glycoamide B (11), 2-(N-methyl-2-phenylacetamido)benzoic acid (12), 2-(methylamine)-methylbenzoate (13), fraxidin (14), scopoletin

    更新日期:2020-09-23
  • Uvarmicranones A and B, two new benzoquinones and cytotoxic constituents from the stems of Uvaria micrantha (A. DC.) Hook. f. & Thomson.
    Nat. Prod. Res. (IF 2.158) Pub Date : 2020-09-22
    Jutatip Boonsombat,Sanit Thongnest,Surasak Kheawchaum,Chulabhorn Mahidol,Somsak Ruchirawat,Hunsa Prawat

    Two novel benzoquinones, uvarmicranones A (1) and B (2), along with 15 known compounds (3 − 17) were isolated from the stems of Uvaria micrantha (Annonaceae). Their structures were elucidated by analyses of NMR and high-resolution mass data. A plausible biosynthetic pathway of uvarmicranone A (1) via Diels-Alder cycloaddition reaction was also proposed. Some isolated compounds were evaluated for their

    更新日期:2020-09-22
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