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  • Four New Prenylated Flavonoids from the Fruits of Sinopodophyllum hexandrum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-17
    Yan-jun Sun, Rui-jie Han, Chen Zhao, Hui Chen, Yan-li Zhang, Wei-sheng Feng

    Four new prenylated flavonoids, sinoflavonoids NF–NI (1–4), were isolated from the fruits of Sinopodophyllum hexandrum by different chromatographic methods such as silica gel, Sephadex LH-20, ODS, and preparative high-performance liquid chromatography (HPLC). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC).

    更新日期:2020-09-18
  • Indole Alkaloids from Hosta plantaginea and Inhibition of Steroid 5α-Reductase Activities In Vitro
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-17
    Rongrui Wei, Qinge Ma

    A new indole alkaloid (1), together with eight known indole alkaloid derivatives (2–9), was isolated from Hosta plantaginea for the first time. The structures of compounds 1–9 were elucidated on the basis of comprehensive spectroscopic analyses and references. Compounds 1–9 were evaluated for their inhibition of steroid 5α-reductase activity in vitro. Among them, compounds 1 and 2 showed important

    更新日期:2020-09-18
  • Glycosylation of Glaucocalyxin a and Evaluation of Its Cytotoxic Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-16
    Zhaobao Xiang, Yan Zhang, Yongsheng Jin, Bin Sun, Gang Chen

    The 7,14-diglucoside of glaucocalyxin A was prepared by a five-step reaction. Its structure was confirmed by spectroscopic methods, and its cytotoxic activity was tested by the MTT method.

    更新日期:2020-09-16
  • Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N -Containing Linkers
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-16
    D. V. Reshetnikov, S. S. Patrushev, E. E. Shults

    8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker

    更新日期:2020-09-16
  • Synthesis of 3 α ,20 S -Dihydroxydammar-24-en-12-One β -D-Glucopyranosides
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-16
    L. N. Atopkina, V. A. Denisenko

    3α,20S-Dihydroxydammar-24-en-12-one 3-, 20-, and 3,20-di-O-β-D-glucopyranosides, close structural analogs of chikusetsusaponin-LT8 glycoside from Panax japonicus, were synthesized for the first time. Condensation of 3,20S-dihydroxydammar-24-en-12-one (1) with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (6) in the presence of Ag2O gave a mixture of the three acetylated 3-, 20-, and 3,20-di-O-β-Dglucopyranosides

    更新日期:2020-09-16
  • Two New Furan-2-Carboxylic Derivatives from the Leaves of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activities
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Xue Wang, Li-Jia Huang, Meng-Jie Liang, Yin-Ke Li, Wan-Li Zeng, Hai-Ying Xiang, Jing Li, Xin Liu, Qi-Li Mi, Ya-Dong Guo, Guang-Yu Yang, Liang Deng, Qian Gao

    Two new furan-2-carboxylic derivatives (1 and 2), together with three known compounds (3–5), were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-TMV activities. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition

    更新日期:2020-09-15
  • A New Phenolic Acid Derivative from an Insect-Derived Fungus Nigrospora sphaerica (Strain No. ZMT05)
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Weijia Ding, Zhihui Wu, Chan Qin, Jiayan Xie, Min Chen, Chunyuan Li

    A new phenolic derivative, ethyl 4-ethoxy-2-hydroxy-3,6-dimethylbenzoate (1), was obtained from the fungus Nigrospora sphaerica ZMT05 isolated from Oxya chinensis Thunberg. Its structure was elucidated by comprehensive spectroscopic analyses. This compound showed high antifungal activity against Penicillium italicum and moderate activity against Fusarium oxysporum, Colletotrichum musae, and Fusarium

    更新日期:2020-09-15
  • A Cucurbitane Aldehyde from the Fruit Pulp of Momordica charantia
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Chiy-Rong Chen, Yun-Wen Liao, Jue-Liang Hsu, Yun-Sheng Lin, Chi-I Chang

    A cucurbitane triterpenoid, 7β-butoxy-3β-hydroxy-25-methoxycucurbita-5,23(E)-dien-19-al (1), was isolated from the fruit pulp of Momordica charantia. Structure determination of the new compound was accomplished by spectroscopic analyses including 1D and 2D NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS and comparison with the data of known analogues.

    更新日期:2020-09-15
  • Bambusicolasides VII and VIII, Two New Glucosides from the Bamboo Aphid Pseudoregma bambusicola
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Puzhao Zhang, Shao Feng, Yamei Zhang

    Two new glucosides, bambusicolasides VII (1) and VIII (2), were isolated from the ethanolic extract of the bamboo aphid Pseudoregma bambusicola. The structures of the two glucosides were identified as 7-O-[2-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-2,5-dimethylchromone (1) and 1,3-di-(O-β-D-glucopyranosyl)-6-methyl-7-nitro-8-naphthol (2) on the basis of spectral data as well as chemical methods

    更新日期:2020-09-15
  • Amino-Acid Derivatives of Pyranocoumarins
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    I. V. Krasylov, V. S. Moskvina, S. V. Shilin, V. P. Khilya

    A methodology for synthesizing amino-acid derivatives of pyranocoumarins in three steps using pyranocoumarin oximes as starting compounds was developed. A series of pyranocoumarins containing the amino acids glycine, alanine, phenylalanine, methionine, leucine, and β-alanine in their structures could be prepared using the activated ester method.

    更新日期:2020-09-15
  • Total Synthesis of Cyclic Lipodepsipeptide Ophiotine
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Jing Wang, Chao Liu, Hong-Gang Hu, Yan Zou, Qin-Jie Zhao, Guang-Ming Ye

    The first total synthesis of the natural nematicidal cyclic lipodepsipeptide ophiotine via a convergent strategy that involved both solid-phase peptide synthesis and liquid phase chemistry is reported. The pre-made dipeptide building block was synthesized in the liquid phase, which was then assembled into the peptide backbone through standard Fmoc chemistry on solid support. After cleavage from the

    更新日期:2020-09-15
  • Two New Coumarins from the Roots and Stems of Nicotiana tabacum and their Bioactivity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Li-Jun Zhu, Dian Luo, Na Lv, Yin-ke Li, Qi-Li Mi, Jin Wang, Wei-Song Kong, Qian Gao, Gan-Peng Li, Guang-Yu Yang, Qiu-Fen Hu, Ying Guan, Yan-Qing Ye

    Two new coumarins, 6-hydroxymethyl-3-prenyl-7-methoxycoumarin (1) and 6-hydroxyethyl-3-prenyl-7- methoxycoumarin (2), together with three known coumarins (3–5), were isolated from the roots and stems of Yunyan-300, a variety of Nicotiana tabacum L. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-methicillinresistant

    更新日期:2020-09-15
  • A New Monoterpene-Flavanone Conjugate from the Aerial Parts of Chimonanthus grammatus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    Yuxian Li, Ke Sun, Lin Liang, Man Wang, Zhenliang Sun

    A new monoterpene-flavanone conjugate, grammatin A (1), along with four known compounds (2–5), were isolated from the aerial parts of Chimonanthus grammatus. Their structures were elucidated through extensive analysis of NMR spectroscopic data in combination with the reported literature. All these compounds were isolated from this plant for the first time.

    更新日期:2020-09-14
  • A New Coumarin from the Bark of Cryptocarya bracteolata
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    Nurdin Saidi, Khalijah Awang, Mustanir Yahya

    Isolation of compounds from the bark of Cryptocarya bracteolata yielded a new coumarin, 6,7,8-trimethoxy-3,4-dihydrocoumarin. The structure of the compound was elucidated from spectral data, including IR, UV, 1D NMR (13C, 1H, and DEPT), 2D NMR (HMQC, HMBC, and COSY), EI-MS, and ESI-MS techniques.

    更新日期:2020-09-14
  • A New Furan Derivative from Harposporium sp. YMF1.01735
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    Qiao-Mei Zheng, Sisommay Souvanhnachit, Xin Wang, Guo-Hong Li

    The chemical constituents of the endoparasitic fungus Harposporium sp. YMF1.01735 were studied. A new furan harposporin A (1) with a known aureonitol (2) were isolated and identified from the EtOAc extract of the strain. Their structures were elucidated by NMR and MS analysis. This is the first report on the chemical constituents of the genus Harposporium.

    更新日期:2020-09-14
  • New Flavonoid Glycoside from Thalictrum minus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    B. D. Komilov, M. A. Agzamova, I. M. Isaev, K. A. Eshbakova

    The new flavonoid diglycoside thamiflaside was isolated from the aerial part of Thalictrum minus. The chemical structure of this glycoside was determined as apigenin 7-O-α-L-2″′-methoxyrhamnopyranosyl-(1→6)-β-D-glucopyranoside based on PMR and 13C NMR (DEPT, HSQC, HMBC) physicochemical methods.

    更新日期:2020-09-14
  • Isolation and Cytotoxicity of Isocoumarins from the Entomogenous Fungus Setosphaeria sp.
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    Sha-Sha Liu, Wen-Bin Gao, Jie Kang, Xiao-Hui Yang, Fei Cao, Fan-Dong Kong, You-Xing Zhao, Du-Qiang Luo

    A new isocoumarin compound named setosphacohol A (1), together with six known ones, alternariol (2), isoaltenuene (3), phomasatin (4), alternariol 5-O-methyl ether (5), 1-deoxyrubralactone (6), and rubralactone (7), was isolated from the entomogenous fungus Setosphaeria sp. The structure of the new compound was elucidated by analysis of the 1D and 2D spectroscopic data as well as MS. Compounds 2, 5

    更新日期:2020-09-14
  • Synthesis of Several Cytisine Derivatives and their Cytotoxicities against A431, A375, and HCT 116 Tumor Cell Lines
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    P. R. Petrova, A. V. Koval′skaya, I. P. Tsypysheva, A. S. Bunev

    Cytotoxicities of the quinolizidine alkaloid (–)-cytisine and 19 of its derivatives with substituents in the 3-, 9-, and 11-positions were assessed against A431 (epidermal carcinoma), A375 (melanoma), and HCT 116 (colorectal carcinoma) tumor cell lines using the MTT assay (etoposide reference drug). Practically all synthesized compounds at a concentration of 30 μM possessed slight ability to inhibit

    更新日期:2020-09-12
  • New Sesquiterpene Lactone from Inula britannica
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    D. E. Dusmatova, K. K. Turgunov, Kh. M. Bobakulov, R. F. Mukhamatkhanova, I. D. Sham’yanov, B. Tashkhodzhaev, N. D. Abdullaev

    A new sesquiterpene lactone that was called inulonolide was isolated from Inula britannica. Its structure was established as 2-keto-1β,10β-epoxy-5,7,8,11α(H)-guai-3-en-8,12-olide based on spectral data and an X-ray crystal structure analysis.

    更新日期:2020-09-12
  • Chemical Composition of Flowers of Yucca elephantipes Cultivated in Georgia
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    E. P. Kemertelidze, M. M. Benidze, V. G. Nebieridze, A. V. Skhirtladze, M. Ganzera

    Three sesquiterpene glycosides, i.e., nerolidol derivatives, and steroidal glycosides of the 3-furostanol and 1-spirostanol series, one of which was new and characterized as (25R)-26-O-β-D-Glcp-5α-furostan-3β,22α,26-triol 3-O-β-D-Xylp-(1→3)-[O-β-D-Glcp-(1→3)-O-β-D-Glcp-(1→2)]-O-β-D-Glcp-(1→4)-O-β- D-Galp, were isolated from flowers of Yucca elephantipes Regel cultivated in Georgia. The structures of

    更新日期:2020-09-12
  • Methylation of Quercetin by Diazomethane and Hypoglycemic Activity of its Tetra- O -Methyl Ether
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    E. R. Karimova, L. A. Baltina, L. V. Spirikhin, T. A. Sapozhnikova, S. F. Gabdrakhmanova, N. S. Makara

    The tetra-O-methyl ether of quercetin (QU) 3 (54%), 3,7,4′-tri-O-methyl ether 4 (30%), and a previously unreported 3,7,3-tri-O-methyl ether of QU 5 (7%) were obtained via methylation of QU by an excess of diazomethane in dioxane. Their structures were established using 2D NMR (1H–1H COSY, 1H–1H NOESY, 1H–13C HSQC, 1H–13C HMBC). Tetra-O-methyl ether of QU 3 exhibited pronounced hypoglycemic activity

    更新日期:2020-09-12
  • A New Phenanthraquinone from the Aerial Parts of Cremastra appendiculata
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    Yu-Peng Li, Ya-Ping Chen, Ya-Ting Shao, Yong-Sheng Tao, Rong-Ping Zhang

    A new phenanthraquinone, 2,6-dihydroxy-8-methoxy-1,4-phenanthraquinone (1), was isolated from the aerial parts of Cremastra appendiculata. The structure of the new compound was determined on the basis of NMR (1D and 2D) and mass spectroscopic analysis.

    更新日期:2020-09-12
  • Hypolipidemic Lactone Derivatives from Highland Barley Monascus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-28
    Rongrui Wei, Qinge Ma

    A new lactone, named 9-allyl-5-methyl-1H-difuro-isochromene-1,8-dione (1), together with nine known lactone derivatives (2–10), was isolated from highland barley Monascus for the first time. Compounds 1–10 were studied by spectroscopic methods and comparison with references and evaluated for their hypolipidemic activities by measuring the triglyceride content in HepG2 cells with simvastatin as positive

    更新日期:2020-07-28
  • A New Sesquiterpene Lactone from Eupatorium chinense and its Anti-TNBC Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-28
    Qing-li Jiang, Pan-ting Shou, Min-juan Sun, Guan-feng Wang, Neng-ming Lin, Hua-jun Zhao, Bo Yang

    A new sesquiterpene lactone, namely, eupachiilide A (1), as well as two known sesquiterpene lactones, eupachinilide B (2), and eupalinilide G (3), were isolated from the whole plant of Eupatorium chinense L. The new structure was elucidated by spectral methods, especially 2D NMR techniques. The three natural compounds were all Michael addition acceptors, whose electrophilic moiety could react with

    更新日期:2020-07-28
  • A New Dimeric Lignan from Machilus philippinensis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-28
    C. Y. Chen, C. T. Chen, S. L. Liu, C. L. Kao, W. J. Li, H. C. Yeh, H. T. Li, H. W. Chang

    A new dimeric lignan, machiphilippin (1), was isolated from the stems of Machilus philippinensis Merr. (Lauraceae). The structure of the new dimeric lignan was elucidated by chemical and physical evidence.

    更新日期:2020-07-28
  • Synthesis and Antioxidant Activity Evaluation of Trolox Derivatives
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-28
    Qian Xu, Luyun Zhang, Dazhao Zhan, Guangqing Xia, Junyi Zhu, Hao Zang

    To find potent antioxidants, 16 novel Trolox derivatives were designed and synthesized via a reduction and esterification reaction. The chemical structures were characterized by NMR and MS. Trolox derivatives were employed to explore the potential structure–antioxidant activity relationships using three different assays. The results revealed that some of the synthesized compounds exhibited stronger

    更新日期:2020-07-28
  • Two New Oleanane Triterpenoids from Syzygium samarangense
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-27
    Yi-Kao Hu, Li Wang, Yan Zhao, Jing-Ping Liu, Ji-Hua Wang, Yong Zhao

    Two new oleanane triterpenoids, sysamarins F (1) and G (2), along with one known analogue (3), were isolated from the leaves of Syzygium samarangense. Their structures were elucidated by means of extensive spectroscopic techniques, including interpretation of 1D and 2D NMR spectra and comparison with the values reported in the literature.

    更新日期:2020-07-27
  • Rearrangement of Epoxide Derivatives Semisynthesized from β -Himachalene using Lewis and Bronsted Acids Catalysis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-27
    Mohamed Dakir, Mustapha Ait Elhad, Abdelouahd Oukhrib, Noureddine Mazoir, Ahmed Benharref

    The acid-catalyzed rearrangement of epoxides 3a, 4a, 6a, and 7a derived from β-himachalene, the major constituent of Cedrus atlantica essential oil, has been studied using various Lewis and Bronsted acids. Several new enantiomerically pure ketones were obtained in good yields and high selectivities. All products obtained were fully characterized by 1H and 13C NMR, and the mechanistic explanations for

    更新日期:2020-07-27
  • Correction to: Chemical Constituents of Zanthoxylum bungeanum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    Bing-Qiang Zhu, Jing-Fan Yang, Tong-Tong Song, Xiao-Fei Li, Tao Guo, Li-Li Wang, Ya Wang, Jun Chang

    To the article “Chemical Constituents of Zanthoxylum bungeanum,” by Bing-Qing Zhu, Jing-Fan Yang, Tong-Tong Song, Xiao-Fei Li, Tao Guo, Li-Li Wang, Ya Wang, and Jun Chang, Vol. 56, No. 1, pp. 164–165, January, 2020.

    更新日期:2020-07-26
  • Phenolic Constituents of Syzygium austroyunnanense
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    Feng Li, Meng-Jia Li, Yi-Kao Hu, Jing-Ping Liu, Ding-Li Zhang, Yong Zhao

    Twelve phenolic compounds, including one new phloroglucinol derivative, were isolated from the leaves of Syzygium austroyunnanense. Their structures were elucidated based on the spectroscopic data and by comparison with the literature. All of compounds were firstly isolated from this species.

    更新日期:2020-07-26
  • A New Phenolic Glycoside from the Seeds of Moringa oleifera
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    Min-Min Tang, Guang-Ying Chen, Kun-Chi Jiang, Ming-Yue Luo, Hao Wu, Bing Hu, Xue-Ming Zhou

    A new phenolic glycoside derivative, moringapyranosyl (1), along with five known phenolic glycoside derivatives (2–6), was isolated from the seeds of Moringa oleifera. Their structures were identified by spectroscopic analyses and by comparison of their spectral data with those reported in the literature. The inhibitory activities of all compounds against α-glucosidase were evaluated. Compounds 1–6

    更新日期:2020-07-26
  • A New Apocarotenoid of Cinnamomum burmannii
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    R. J. Lin, C. L. Kao, S. L. Liu, H. C. Yeh, P. L. Song, H. T. Li, H. M. Wang, H. W. Chang, C. Y. Chen

    A new apocarotenoid, burmannic acid (1), was isolated from the roots of Cinnamomum burmannii (Nees & T. Nees) Blume (Lauraceae). The structure of the new apocarotenoid was elucidated by chemical and physical evidence.

    更新日期:2020-07-26
  • Indole Alkaloids from Vinca erecta , Structure and Stereochemistry
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    B. Tashkhodzhaev

    Stereochemical and structural aspects of series of indoline, α-methyleneindoline, indolenine, indole, and 2-oxoindoline alkaloids. The stereochemistry of the molecules is analyzed. The descriptors of the chiral centers of indole alkaloids from Vinca erecta are determined.

    更新日期:2020-07-26
  • Synthesis and Analgesic Activity Assessment of Furanolabdanoid Conjugates with Glucuronic Acid
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    O. I. Brusentseva, Yu. V. Kharitonov, M. P. Dolgikh, T. G. Tolstikova, E. E. Shul’ts

    Phlomisoic acid reacted with methyl-1-deoxy-2,3,4-tri-O-acetyl-1-bromo-α-D-glucopyranuronate to form the 18-O-β-D-(glucuronopyranoside)-6′-O-methyl ester of 15,16-epoxylabda-8(9),13,14-triene. Reductive amination of methyl 16-formyl-15,16-epoxylabda-8(9),13,14-trienoate or this β-D-glucuronopyranoside of 16-formyl-15,16-epoxylabda-8(9),13,14-triene by propargylamine in the presence of NaBH4 gave the

    更新日期:2020-07-26
  • A New 27-Norcucurbitane Triterpenoid from the Fruits of Momordica charantia var. abbreviata
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-25
    Chiy-Rong Chen, Yun-Wen Liao, Jue-Liang Hsu, Yun-Sheng Lin, Chi-I Chang

    A new 27-norcucurbitane triterpenoid, 5β,19-epoxy-3β-hydroxy-19(R)-methoxy-27-norcucurbita-6,23(E)-dien-25-one (1), was isolated from the fruits of Momordica charantia var. abbreviata. Its structure was elucidated by spectroscopic analyses including 1D and 2D NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and comparison with the data of known analogues.

    更新日期:2020-07-25
  • Synthesis of New Exocyclic Allenes with Diterpene Fragments
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-25
    I. M. Sakhautdinov, R. N. Malikova

    New stable allenes with exocyclic cumulene groups were synthesized from N-maleopimarimide-substituted amino acids using phenyl(triphenylphosphoranylidene)succinimide, 2-fluorophenyl(triphenylphosphoranylidene)-succinimide, and benzyl(triphenylphosphoranylidene)succinimide.

    更新日期:2020-07-25
  • Cytotoxic Hydroperoxycochliodinol Derivative from Endophytic Chaetomium sp. Isolated from Salvia officinalis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-25
    Siham Mallouk, Naglaa Salah El-Deen Mohamed, Abdessamad Debbab

    The endophytic fungus Chaetomium sp. was separated from the medicinal plant Salvia officinalis growing in Egypt and cultivated on solid rice medium. Chemical investigation of the EtOAc extract yielded a new hydroperoxycochliodinol derivative (1) in addition to several known compounds, which included cochliodinol (2), isocochliodinol (3), chaetomin (4), and two simple indole derivatives (5, 6). The

    更新日期:2020-07-25
  • A New Austalide from Penicillium sp. SO01
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-25
    Jia Wang, Yining Sang, Siqi Tang, Peng Zhang

    Five austalide meroterpenoids, including a new one named 13-deoxyaustalide Q acid methyl ester, were isolated from the ethyl acetate extract of the fungus Penicillium sp. SO01. The structure of the new compound was determined on the basis of IR, UV, HR-ESI-MS NMR spectra and CD data. The cytotoxicities of compound 1 against three human tumor cell lines were also tested, with IC50 values of 27.66 μM

    更新日期:2020-07-25
  • Synthesis and Antimicrobial Activity of New Drimane and Homodrimane Sesquiterpenoids with Oxadiazole and Thiadiazole Fragments
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-25
    A. N. Aricu, K. I. Kuchkova, E. S. Secara-Cushnir, A. N. Barba, N. D. Ungur, N. Vornicu

    Series of drimane and homodrimane sesquiterpenoids with oxadiazole and thiadiazole fragments were synthesized. Their antifungal and antibacterial activities were studied.

    更新日期:2020-07-25
  • Bioactive Alkaloids from Whole Plants of Thalictrum cultratum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-25
    Na Lv, Dian Luo, Li-Jun Zhu, Yong Xu, Jin Wang, Wei-Song Kong, Jin Li, Qian Gao, Qi-Li Mi, Min Zhou, Guang-Yu Yang, Qiu-Fen Hu, Hai-Tao Huang

    Two new tricyclic alkaloids (1 and 2), together with three known (3–5) alkaloids, were isolated from the whole plants of Thalictrum cultratum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–5 were tested for their anti-rotavirus activity. The results revealed that compounds 1–5 exhibited potent anti-rotavirus activity with therapeutic

    更新日期:2020-07-25
  • A New Pyrone from Cinnamomum macrostemon
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-24
    Chung-Yi Chen, Chi-Ming Liu, Hui-Ming Wu, Hung-Chun Yeh, Wei-Jen Li, Hsing-Tan Li, Hui-Wen Chang

    Cinnamopyrone (1), a new cinnamomum 2-pyrone, has been isolated from the roots of Cinnamomum macrostemon (Lauraceae). The structure was characterized and identified by spectral analysis.

    更新日期:2020-07-24
  • 4-Methyl-7-Amino/Amido Coumarin Derivatives as Potential Antimicrobials and Antioxidants
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-24
    Muthipeedika Nibin Joy, Yadav D. Bodke, Sandeep Telkar

    An array of previously synthesized 4-methyl-7-amino and amido coumarins 4a–u has been screened for their antimicrobial and antioxidant properties. Some of the compounds exhibited promising antibacterial and antifungal activities (MIC ranging from 4–64 μg/mL) when compared to the respective standards. Compound 4u showed comparable antibacterial activity with the standard, ciprofloxacin, whereas compounds

    更新日期:2020-07-24
  • New Compounds from Flowers of Phlojodicarpus sibiricus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-24
    D. N. Olennikov, N. K. Chirikova

    Chromatographic separation of the MeOH extract from flowers of Phlojodicarpus sibiricus (Fisch.) Koso.-Pol. (Apiaceae) isolated 27 compounds including three new glycosides, the structures of which were established by UV, IR, and NMR spectroscopy and mass spectrometry as (R)-peucedanol -7-O-(6″-O-β-D-apiofuranosyl)-β-D-glucopyranoside-3′-O-β-D-glucopyranoside (phlojosibiriside I, 1), diosmetin-7-O-

    更新日期:2020-07-24
  • New Flavonoids from Artemisia frigida
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-24
    D. N. Olennikov

    New flavonoids were isolated from the aerial part of Artemisia frigida Willd. (Asteraceae). Their structures were elucidated using UV, IR, and NMR spectroscopy and mass spectrometry as chrysoeriol-7-O-(2′′-Oacetyl)-β-D-glucopyranoside (2′′-O-acetylthermopsoside), jaceosidin-4′ -O-β-D-glucopyranoside (isojaceoside), and 13 known flavonoids. The influence of the isolated compounds on α-glucosidase activity

    更新日期:2020-07-24
  • Synthesis and First-Time Assessment of o -Eugenol Derivatives against Mycobacterium tuberculosis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-24
    Adriana Marques Moraes, Emerson Teixeira da Silva, James L. Wardell, Marcus V. N. de Souza

    In this work, we report the first-time assessment of o-eugenol, 6-allyl-2-methoxyphenol, and their selected derivatives, against Mycobacterium tuberculosis H37RV, using the MABA susceptibility test. The bromo, nitro, O-alkylated, and reduced derivatives were obtained by standard methods and were characterized by spectroscopic and mass spectral data. Structure–activity relationships were investigated

    更新日期:2020-07-24
  • A Novel Spermidine Macrocyclic Alkaloid from the Roots of Tripterygium wilfordii
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-06
    Jianqun Liu, Qiushan Wu, Jicheng Shu, Rui Zhang, Lifang Liu

    A novel 13-membered spermidine macrocyclic alkaloid, (2R)-9-furoyl-2-phenyl-1,5,9-triazacyclotridecane-4,13-dione, named celacarfurine (1), was isolated from the roots of Tripterygium wilfordii. Its structure has been elucidated on the basis of NMR and MS data. To the best of our knowledge, 13-membered spermidine macrocyclic alkaloids were rarely reported natural products; moreover, the known ones

    更新日期:2020-06-06
  • Synthesis and Cytotoxicity of 28-Oxo-Allobetulone Derivatives
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-06
    E. F. Khusnutdinova, I. E. Smirnova, O. B. Kazakova

    28-Oxo-allobetulone derivatives that were newly synthesized or prepared earlier by modification of ring A (3- and 4-pyridylidene, furfurylidene, azepane, lactam, quinolone, spiroindole, pyrazole, isoxazole, and tetraoxane derivatives) and 3β,19β,28-oleantriol were tested in vitro for cytotoxicity against 60 cell lines of 9 human tumor types. Melanoma SK-MEL-5 and CNS SNB-75 cancer cells died in the

    更新日期:2020-06-06
  • Synthesis from Δ 3 -Carene of Optically Active Macrolides with Fragments of Di- and Triethyleneglycol and Hydrazides of Dicarboxylic Acids
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-06
    M. P. Yakovleva, K. S. Denisova, G. R. Mingaleeva, Yu. V. Myasoedova, L. R. Garifullina, N. M. Ishmuratova, G. Yu. Ishmuratov

    Efficient syntheses of six potentially useful optically pure macroheterocycles with ester and dihydrazide fragments were developed from available natural Δ3-carene through intermediate (31R,33S)-32,32-dimethyl-3(1,3)cyclopropyla-5-oxohexanoic acid using in the key steps [2+1]-reactions of the last with di- or triethylene glycol and [1+1]-condensation of the resulting α,ω-diketodiesters with several

    更新日期:2020-06-06
  • A New Triterpenoid Saponin from Camellia oleifera Fruit Hull
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    Lei Wu, Guo-Qun Li, Zhen Gu, Jian-Ping Fu, Zi-Jiang Li, Jie Zhang, Wei Xiong, Guang-Qiang Ma, Young-Soo Bae

    A new triterpene saponin (1), along with oleanolic acid 3-O-β-D-glucopyranoside (2), were isolated from the fruit shells of Camellia oleifera Abel. The structure of 1 was determined to be 3-O-β-Dglucopyranosyl( 1"→6')α-L-rhamnosyl 27-hydroxyoleanolic acid-28-O-β-D-glucopyranoside, which was established by analyses of their 1H and 13C NMR spectra with the aid of 2D experiments.

    更新日期:2020-06-05
  • Acutinine – A New Quinolin-2-One Alkaloid from Haplophyllum acutifolium
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    M. A. Eshonov, Kh. A. Rasulova

    The new base acutinine and the known alkaloids skimmianine, evoxine, glycoperine, perfamine, and haplamine were isolated from total alkaloids from the aerial part of Haplophyllum acutifolium collected in Jizzakh Oblast, Republic of Uzbekistan. Acutinine was identified as a quinolin-2-one derivative based on spectral characteristics.

    更新日期:2020-06-05
  • Diterpenoid Alkaloids from the Roots of Aconitum iochanicum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    Jiang Hu, Yan Lv, Qiang Li, Xia Mao, Tianfeng Peng, Xiu Gao, Nianhua Jin, Si Yin, Xiaodong Shi, Wei Wang

    Three new diterpenoid alkaloids, namely 1-N-deethyl-1,16-demethoxy-1,16-dihydroxy-N(19)-enaustroconitine A (1), 1-N-deethyl-1,16-demethoxy-1,16-dihydroxy-18-methoxy-N(19)-en-austroconitine A (2), and 1-N-deethyl-1,16-demethoxy-1,16-dihydroxyranaconidine (3), were isolated from the 80% ethanol extract of the roots of Aconitum iochanicum. Structural elucidation of all the compounds was performed by spectral

    更新日期:2020-06-05
  • New Arteannuin B Derivatives and Their Cytotoxic Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    S. G. Klochkov, M. E. Neganova, S. A. Pukhov, S. V. Afanas’eva, Yu. R. Aleksandrova, E. Yu. Yandulova

    Previously unknown conjugates of the natural sesquiterpene lactone arteannuin B, which was isolated from Artemisia annua, were synthesized via Michael reactions with pharmacophoric amines and tested in vitro for cytotoxic activity. The compounds were shown to exhibit antiproliferative properties for various tumor cell lines. The most active derivatives had IC50 values of 8–36 μM, which exceeded that

    更新日期:2020-06-05
  • Synthesis of Derivatives of the 2-Arylquinoline Alkaloid Dubamine and their Cytotoxicity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    A. R. Niyazmetov, E. O. Terent’eva, U. B. Khamidova, Z. S. Khashimova, Sh S. Azimova, V. I. Vinogradova

    5′-Nitro- (2) and 5′-aminodubamine (3) were sequentially synthesized from the alkaloid dubamine. Condensation of 3 with 15 aldehydes gave imines, reduction of which produced secondary amines. Studies of the cytotoxicities for HeLa and HEp-2 cells of the compounds at a concentration of 100 μM revealed several trends. The activity decreased significantly or disappeared at lower concentrations although

    更新日期:2020-06-05
  • A New Tetracyclic Triterpenoid from the Fresh Bark of Ailanthus altissima
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Tian-Hui Zhu, Yu-Fang Wang, Mei Dong, Francoise Sauriol, Chang-Hong Huo, Yu-Cheng Gu, Zhi-Yu Ni

    A new tetracyclic triterpenoid (1) was isolated from the fresh bark of Ailanthus altissima. The structure was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques and high-resolution mass spectrometry.

    更新日期:2020-06-04
  • A New 2 H -pyran from Michelia compressa var. Lanyuensis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    S. L. Liu, Y. S. Tsai, C. T. Chen, H. C. Yeh, C. Y. Chen

    Pressalanin B (1), (–)-anonaine (2), (–)-asimilobine (3), (–)-N-acetylanonaine (4), liriodenine (5), stearic acid (6), 6β-hydroxystigmast-4-en-3-one (7), 6β-hydroxystigmast-4,22-dien-3-one (8), costunolide (9), 11,13-dehydrolanuginolide (10), N-trans-feruloyltyramine (11), N-trans-caffeoyltyramine (12), N-cis-caffeoyltyramine (13), p-hydroxybenzoic acid (14), p-hydroxybenzaldehyde (15), methylparaben

    更新日期:2020-06-04
  • A New Diterpene from Dysoxylum lukii
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Pu-zhao Zhang, Ya-mei Zhang

    A new diterpene, dysokusone G (1), was isolated from the stems of Dysoxylum lukii Merr., along with twelve known compounds, which were reported for the first time from this plant. The structures were elucidated using spectroscopic methods and by comparison with published NMR spectroscopic data.

    更新日期:2020-06-04
  • A New Sesquiterpene from Dendranthema grandiflora Flowers
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Consolacion Y. Ragasa, Madeleine Si, Maria Carmen S. Tan, Deanne Hazel Pelobello, Ming-Jaw Don, Chien-Chang Shen

    Chemical investigation of the dichloromethane extracts of the flowers of Dendranthema grandiflora cv. Yoko Ono afforded a new sesquiterpene lactone, grandiflorolide (1), 1,2-dilinoleoyl-3-linolenoylglycerol (2), a mixture of pseudotaraxasterol (3a), taraxasterol (3b), β-amyrin (3c), α-amyrin (3d), and lupeol (3e) in about 2:1:1:0.5:0.5 ratio, and another mixture of β-sitosterol (4a) and stigmasterol

    更新日期:2020-06-04
  • Two New Isoquinoline Alkaloids from Whole Plants of Thalictrum glandulosissimum and their Anti-TMV Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Qiu-Fen Hu, Ling-Min Liao, Hai-Tao Huang, Yong Xu, Jin Wang, Wei-Song Kong, Qi-Li Mi, Min Zhou, Guang-Yu Yang, Chun-Man Song

    Two new isoquinoline alkaloids, 3-hydroxy-1-(7-hydroxy-6-methylisoquinolin-1-yl)propan-1-one (1) and 3-hydroxy-1-(7-methoxy-6-methylisoquinolin-1-yl)propan-1-one (2) were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus

    更新日期:2020-06-04
  • A New α -Ionone from Michelia champaca
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    S. L. Liu, C. L. Kao, H. C. Yeh, P. L. Song, H. T. Li, C. Y. Chen

    A new α-ionone, (Z)-4-hydroxy-3,5,5-trimethyl-4-(3′-oxobut-1′-enyl)cyclohex-2-enone (1) was isolated from the flower of Michelia champaca L. The structure of the new α-ionone was elucidated by chemical and physical evidence.

    更新日期:2020-06-04
  • Phenylethanoid Glycosides from Callicarpa nudiflora
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Xiao-Jie Yan, Gu Zhi-Xin, Pan Zheng-Hong, Ning De-Sheng, Sheng Huang, Jin-Lei Liu, Dian-Peng Li

    A new phenylethanoid glycoside, named cis-alyssonoside (1), was isolated from the leaves of Callicarpa nudiflora, along with four known phenylethanoid glycosides (2–5). Their structures were determined on the basis of extensive spectroscopic analysis and comparison with literature data. The inhibitory effects on lipopolysaccharide induced nitric oxide (NO) production in RAW264.7 cells of all the compounds

    更新日期:2020-06-04
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