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  • Synthesis and Cytotoxicity of Heterocyclic Amine Derivatives of Podophyllotoxin
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-17
    Dan-li Tian, Hong Chen, Gang Luo, Chun-po Liang

    A series of amine podophyllotoxin derivatives was designed and synthesized by aldehydes reacting with 4β-amino-desoxypodophyllotoxin or 4′-demethyldesoxypodophyllotoxin. The MTT assay was used to test the cytotoxic activity of 11 target compounds on HeLa cells and MCF-7 cells. All the compounds had varying degrees of antitumour activity in vitro. Several compounds showed improved activities against

    更新日期:2020-11-17
  • Synthesis and Transformation of Triterpenoids with a β -Ketonitrile Fragment in Five-Membered Ring A
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-06
    I. A. Tolmacheva, E. V. Igosheva, O. S. Eltsov, V. V. Grishko

    Triterpenoids with a β-ketonitrile group in five-membered ring A were synthesized via intramolecular oxonitrile cyclization of C-3 methyl esters of 1-cyano-substituted 2,3-seco-triterpene acids. The intramolecular cyclization to form the triterpene ketonitriles and subsequent reduction of the oxo groups to give C-1 and C-3 substituents in the β-orientation were confirmed to be stereoselective. Alkaline

    更新日期:2020-11-06
  • New Flavonol Glycosides from Rhodiola quadrifida
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-04
    D. N. Olennikov, N. K. Chirikova

    Chromatographic separation of constituents in the EtOH extract of the herb of Rhodiola quadrifida (Pall.) Fisch. & C. A. Mey. (Crassulaceae) isolated 14 compounds including four new flavonol glycosides 1–4. UV and NMR spectroscopy and mass spectrometry found that the compounds were gossypetin and herbacetin derivatives, i.e., gossypetin-8-O-(2″-O-β-D-glucopyranosyl)-β-D-glucuronopyranoside (rhodiquadrin

    更新日期:2020-11-04
  • New Quinoline Alkaloid Acusine and Crystal Structures of N -Methyl-2-Phenylquinolin-4-One and Pedicine from Haplophyllum acutifolium
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-03
    M. A. Eshonov, Kh. A. Rasulova, K. K. Turgunov, B. Tashkhodzhaev

    The new natural 2-quinoline alkaloid acusine in addition to N-methyl-2-phenylquinolin-4-one and pedicine were isolated from Haplophyllum acutifolium. The structure of acusine was determined using IR and NMR spectral data. The structures of N-methyl-2-phenylquinolin-4-one and pedicine were proven by XSAs.

    更新日期:2020-11-03
  • Hydrogels Based on Cross-Linked Cationic Cellulose Derivatives
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-03
    S. M. Butrim, T. D. Bil’dyukevich, N. S. Butrim, T. L. Yurkshtovich

    Cationization of wood and cotton celluloses using 3-chloro-2-hydroxypropyltrimethylammonium chloride in aqueous suspensions in the presence of various amounts of NaOH followed by cross-linking with epichlorohydrin was studied in detail. The compositions of the cationic cellulose ethers and the reaction efficiency depended strongly on the ratio of the alkylating mixture components. The physicochemical

    更新日期:2020-11-03
  • Cytotoxic Steroids from Sonchus arvensis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-03
    Zhengxiang Xia, Lihua Lu, Lin Li

    A new steroid, 22Z,24R-5α,6α-epoxyergosta-8(14),22-(Z)-diene-3β,7α-diol (1), and seven known steroids were isolated from Sonchus arvensis L. The structures were elucidated by spectroscopic data. All these known compounds except compounds (6 and 7) were isolated from the title plant for the first time. All compounds were evaluated for cytotoxic activities. The results indicated that 1 and 8 showed moderate

    更新日期:2020-11-03
  • New C , O -Glycosylflavones from the Genus Silene
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-03
    D. N. Olennikov, N. I. Kashchenko

    Chromatographic separation of extracts from the aerial parts of three Silene species (Caryophyllaceae) isolated 26 flavonoids including the four new C,O-glycosylflavones acacetin-6-C-(2″-O-β-D-glucopyranosyl)-β-D-glucopyranoside-7-O-β-D-glucopyranoside (sileneside D, 1) from S. jeniseensis Willd., apigenin-6-C-(2″-O-β-D-glucopyranosyl)-β-D-glucopyranoside-8-C-α-L-arabinopyranoside (sileneside E, 2)

    更新日期:2020-11-03
  • Synthesis of Benzofurans Modified by Coumarin and Pyrazole Heterocycles
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    T. V. Shokol, N. V. Gorbulenko, M. S. Frasinyuk, V. P. Khilya

    Reactions of 7-hydroxy-2-methyl-8-formylisoflavone with 4-chloromethylcoumarins synthesized 8-(coumarin-4-yl)furo[2,3-h]chromones, which reacted with 2-bromoacetylbenzofuran to produce 8-(benzofuroyl)furo [2,3-h]chromone. Recyclization of the corresponding furochromones through the action of hydrazine hydrate gave 4-hydroxybenzofurans with pyrazole and coumarin or benzofuroyl substituents.

    更新日期:2020-11-02
  • Hypolipidemic Activity of Monacolin Derivatives from the Highland Barley Monascus purpureus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    Rongrui Wei, Qinge Ma, Wei Jiang, Guoyue Zhong, Zhipei Sang

    A new monacolin derivative, namely (1S,2S,5′R,6R,8aR)-7-hydroxy-2,6-dimethyl-8-prenyl-1,2,6,8atetrahydronaphthalene-4′,5′-dihydro-2H-pyran-1′-one (1), and five known monacolin derivatives (2–6) were separated from the highland barley Monascus purpureus Went. for the first time. Their structures were elucidated on the basis of 1D and 2D NMR, HR-ESI-MS, and relevant references. Compounds 1–6 were tested

    更新日期:2020-11-02
  • A New Germacrane-Type Sesquiterpenoid Isolated from Salvia cavaleriei var. simplicifolia
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    Zhenghong Guo, Xiaoyan Tao, Ye Hu, Guoyong Luo, Xiang Yu, Yan Zhang, Wude Yang

    Salvia cavaleriei var. simplicifolia Stib., a common Chinese herbal medicine, is prescribed to treat dysentery, hemoptysis, boils, and fall injuries. Previous phytochemical investigations have resulted in the isolation of terpenoids, steroids, and phenolic compounds. In this paper, a new germacrane-type sesquiterpenoid named 8,14-O-ditigloyl-9,12-O-diacetyl-6R,7R,8R,9R,12,14-pentahydroxygermacra-1(10)E

    更新日期:2020-11-02
  • A New C13-Norisoprenoid from the Fruits of Chaenomeles sinensis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    Meng Li, Zhi-guang Zhang, Jing-ya Shi, Ya-ge Li, Jing-ke Zhang, Jin-jin Lv, Xiao-ke Zheng, Wei-sheng Feng

    A new C13-norisoprenoid, chaenomelesterpenoid C (1), was isolated from the fruits of Chaenomeles sinensis (Dum.Cours.) Koehne together with a known compound, linarionoside C (2). The structure of compound 1 was determined by NMR and MS analysis. Meanwhile, the protective effects of the compounds were tested against corticosterone-induced damage in PC-12 cells using real time cellular analysis (RTCA)

    更新日期:2020-11-02
  • Two New Isobenzofurans from the Roots of Yunnan Local Sun Cured Tobacco and Their Bioactivities
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    Li-Jia Huang, Xue Wang, Meng-Jie Liang, Yin-Ke Li, Wei-Shong Kong, Xin Liu, Hai-Ying Xiang, Qian Gao, Qi-Li Mi, Liang Deng, Guang-Yu Yang, Ya-Dong Guo, Jing Li

    Two new isobenzofurans, 5-(methoxymethyl)-2,2-dimethyl-2H-furo[3,4-h]chromen-7(9H)-one (1) and 5-(2-methoxyethyl)-2,2-dimethyl-2H-furo[3,4-h]chromen-7(9H)-one (2), together with two known isobenzofurans (3 and 4), were isolated from the roots of Yunnan local sun cured tobacco. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were

    更新日期:2020-11-02
  • New Cycloartane Glycoside from Astragalus mucidus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    M. A. Agzamova, A. A. Zhanibekov, M. D. Alaniya, A. V. Skhirtladze, V. D. Mshvildadze

    A new glycoside was isolated from the aerial part of Astragalus mucidus. Its chemical structure was characterized as a cycloartane triterpenoid using PMR and 13C NMR spectra (COSY, HMQC, HMBC). The glycoside was called cyclomucidoside A.

    更新日期:2020-11-02
  • A New Compound from Polygonum amplexicaule var. sinense
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    Guang-ming Xu, Fan Zhao, Fang Liu, Zhi-ying Yuan, Bi-qing Zhao, Li Li, Jia Cai, Ling-xi Li, Wei-he He, Xiao-jiang Zhou

    One new phenyl group dimeric compound, named polygamol A (1), together with two known compounds, 2,2-bis[4-(2,3-dihydroxypropoxy)phenyl]propane (2) and 1,3-di-O-[2′,2′-di-(p-phenylene)isopropylidene]-glycerol (3), were isolated from the roots of Polygonum amplexicaule var. sinense. The structures of these compounds were elucidated based on spectroscopic analysis. The new compound exhibited weak activity

    更新日期:2020-11-02
  • A New N -Fatty Acyl Tryptamine from Annana atemoya
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    C. T. Chang, C. L. Kao, H. C. Yeh, Z. Y. Fang, H. T. Li, C. Y. Chen

    A new N-fatty acyl tryptamine, N-nonadecanoyl-4,5-dihydroxytryptamine (1), was isolated from the stems of Annona atemoya. The structure of the new tryptamine-derived amide was elucidated by chemical and physical evidence.

    更新日期:2020-11-02
  • A New Sesquiterpenoid and Bioactive Constituents of Curcuma zedoaria
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    Jen-Wen Hsiao, Li-Chai Chen, Chien-Liang Lin, Tsung-Hsien Chang, Chun-Lin Chen, Ping-Jyun Sung, Ming-Jen Cheng, Ching-Ju Hung, Jih-Jung Chen

    A new sesquiterpenoid derivative, 13-hydroxy-1-oxocurzerenone (1), has been isolated from the rhizomes of Curcuma zedoaria, together with seven known compounds, 1-oxocurzerenone (2), curcolone (3), curcumenone (4), procurcumenol (5), curcumenol (6), zerumin A (7), and labda-8(17), 12-diene-15,16-dial (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among

    更新日期:2020-11-02
  • New Norneolignan and Bioactive Constituents of Clitoria ternatea
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-11-02
    Fu-Sen Wu, Ching-Ju Hung, Chien-Liang Lin, Tsung-Hsien Chang, Chun-Lin Chen, Ping-Jyun Sung, Ming-Jen Cheng, Hsueh-Yang Huang, Jih-Jung Chen

    A new norneolignan derivative, clitorternalactone (1), has been isolated from the stems of Clitoria ternatea, together with six known compounds, clitorienolactone A (2), myricetin 3-glucoside (3), quercetin 3-glucoside (4), kaempferol 3-glucoside (5), taraxerol (6), and taraxerone (7). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, compound

    更新日期:2020-11-02
  • A New Flavone C -Glucoside from Aquilaria agallocha
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-10-31
    C. T. Chang, C. L. Kao, H. C. Yeh, P. L. Song, H. T. Li, C. Y. Chen

    5,7,2′,3′,4′,5′-Hexahydroxyflavone 6-C-glucoside (1), 5-hydroxy-4′,7-dimethoxyflavone, luteolin-7,3′,4′-trimethyl ether, 5,3′-dihydroxy-7,4′-dimethoxyflavone, persicogenin, quercetin-3-O-rhamnoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-rhamnoside, tamarixetin-3-O-rhamnoside, (+)-syringaresinol, (+)-diasyringaresinol, (+)-epi-syringaresinol, liriodendrin, methyl-β-D-xylopyranoside, methyl-β-Dglucopyranoside

    更新日期:2020-11-02
  • A Novel Compound from the Bark of Diospyros lotus and their Urease Inhibitory Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-10-31
    Abdur Rauf, Abdullah S. M. Aljohani, Fahad A. Alhumaydhi, Saima Naz

    One novel dimeric naphthoquinone, 1′,4′-dihydroxy-5,8-dimethoxy-11,11′-dimethyl-[7,3′-binaphthalene]-1,4,5′,8′-tetraone, was isolated from the chloroform-soluble fraction of Diospyros lotus bark. The chemical structure of compound 1 was elucidated by advanced spectroscopy techniques, such as 1H, 13C NMR, HMBC, HSQC, COSY, and NOSEY. The chloroform extract and compound 1 were evaluated for their urease

    更新日期:2020-11-02
  • A New Flavonoid Glycoside from Scutellaria barbata
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-10-31
    Yang Liu, Xu-Hua Huang, Jia Chen, Jian-Hua Shao, Chun-Chao Zhao

    A new flavonoid glycoside 1, together with nine known compounds, has been isolated from Scutellaria barbata D. Don. The structure of compound 1 was elucidated as acacetin 7-O-β-D-galactopyranosyl(1→2)-β-Dglucopyranoside by spectroscopic data (1D and 2D NMR methods) and chemical evidences. Additionally, compound 1 displayed potent inhibitory activity against α-glucosidase with an IC50 value of 8.9 μM

    更新日期:2020-11-02
  • Synthesis of 7-( N -12-Cytisinylpropoxy)Isoflavones
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-10-31
    S. P. Bondarenko, O. G. Makarenko, V. I. Vinogradova, M. S. Frasinyuk

    The reactions of cytisine with isoflavone glycidyl ethers were investigated. A series of cytisine–isoflavone conjugates were regioselectively synthesized via opening the oxirane ring by cytisine.

    更新日期:2020-11-02
  • Two New Flavones from Salvia plebeia and Their Anti-Angiogenic Activities
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-10-31
    Qinge Ma, Rongrui Wei, Qixin Lu, Haofeng Huang, Dongmei Guo, Lin Jiang

    Two new flavones, namely 5-hydroxy-2-(4′-hydroxyphenyl)-6,12,13-trimethoxypyrano-xanthene-4,9-dione (1) and 5-hydroxy-2-(3′-methoxy-4′-hydroxyphenyl)-6-methoxy-11-isopropyl-pyranochromene-4,9-dione (2), were isolated from Salvia plebeia. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR spectral data. Compounds 1 and 2 were evaluated for their anti-angiogenic

    更新日期:2020-11-02
  • Acyl Lipids and Lipophilic and Phenolic Compounds from Rare Plant Species
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-10-31
    E. S. Bogdanova, V. N. Nesterov, L. M. Kavelenova, R. R. Sarvarova, S. V. Saksonov, O. A. Rozentsvet

    Fifteen species of rare calciphyte plants growing in Samara Oblast were studied. The most variable of the studied quantitative parameters (acyl lipids, pigments, phenolic compounds) were lipids and phenolic compounds, in contrast to pigments and fatty acids.

    更新日期:2020-11-02
  • Four New Prenylated Flavonoids from the Fruits of Sinopodophyllum hexandrum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-17
    Yan-jun Sun, Rui-jie Han, Chen Zhao, Hui Chen, Yan-li Zhang, Wei-sheng Feng

    Four new prenylated flavonoids, sinoflavonoids NF–NI (1–4), were isolated from the fruits of Sinopodophyllum hexandrum by different chromatographic methods such as silica gel, Sephadex LH-20, ODS, and preparative high-performance liquid chromatography (HPLC). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC).

    更新日期:2020-09-18
  • Indole Alkaloids from Hosta plantaginea and Inhibition of Steroid 5α-Reductase Activities In Vitro
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-17
    Rongrui Wei, Qinge Ma

    A new indole alkaloid (1), together with eight known indole alkaloid derivatives (2–9), was isolated from Hosta plantaginea for the first time. The structures of compounds 1–9 were elucidated on the basis of comprehensive spectroscopic analyses and references. Compounds 1–9 were evaluated for their inhibition of steroid 5α-reductase activity in vitro. Among them, compounds 1 and 2 showed important

    更新日期:2020-09-18
  • Glycosylation of Glaucocalyxin a and Evaluation of Its Cytotoxic Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-16
    Zhaobao Xiang, Yan Zhang, Yongsheng Jin, Bin Sun, Gang Chen

    The 7,14-diglucoside of glaucocalyxin A was prepared by a five-step reaction. Its structure was confirmed by spectroscopic methods, and its cytotoxic activity was tested by the MTT method.

    更新日期:2020-09-16
  • Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N -Containing Linkers
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-16
    D. V. Reshetnikov, S. S. Patrushev, E. E. Shults

    8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker

    更新日期:2020-09-16
  • Synthesis of 3 α ,20 S -Dihydroxydammar-24-en-12-One β -D-Glucopyranosides
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-16
    L. N. Atopkina, V. A. Denisenko

    3α,20S-Dihydroxydammar-24-en-12-one 3-, 20-, and 3,20-di-O-β-D-glucopyranosides, close structural analogs of chikusetsusaponin-LT8 glycoside from Panax japonicus, were synthesized for the first time. Condensation of 3,20S-dihydroxydammar-24-en-12-one (1) with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (6) in the presence of Ag2O gave a mixture of the three acetylated 3-, 20-, and 3,20-di-O-β-Dglucopyranosides

    更新日期:2020-09-16
  • Two New Furan-2-Carboxylic Derivatives from the Leaves of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activities
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Xue Wang, Li-Jia Huang, Meng-Jie Liang, Yin-Ke Li, Wan-Li Zeng, Hai-Ying Xiang, Jing Li, Xin Liu, Qi-Li Mi, Ya-Dong Guo, Guang-Yu Yang, Liang Deng, Qian Gao

    Two new furan-2-carboxylic derivatives (1 and 2), together with three known compounds (3–5), were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-TMV activities. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition

    更新日期:2020-09-15
  • A New Phenolic Acid Derivative from an Insect-Derived Fungus Nigrospora sphaerica (Strain No. ZMT05)
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Weijia Ding, Zhihui Wu, Chan Qin, Jiayan Xie, Min Chen, Chunyuan Li

    A new phenolic derivative, ethyl 4-ethoxy-2-hydroxy-3,6-dimethylbenzoate (1), was obtained from the fungus Nigrospora sphaerica ZMT05 isolated from Oxya chinensis Thunberg. Its structure was elucidated by comprehensive spectroscopic analyses. This compound showed high antifungal activity against Penicillium italicum and moderate activity against Fusarium oxysporum, Colletotrichum musae, and Fusarium

    更新日期:2020-09-15
  • A Cucurbitane Aldehyde from the Fruit Pulp of Momordica charantia
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Chiy-Rong Chen, Yun-Wen Liao, Jue-Liang Hsu, Yun-Sheng Lin, Chi-I Chang

    A cucurbitane triterpenoid, 7β-butoxy-3β-hydroxy-25-methoxycucurbita-5,23(E)-dien-19-al (1), was isolated from the fruit pulp of Momordica charantia. Structure determination of the new compound was accomplished by spectroscopic analyses including 1D and 2D NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS and comparison with the data of known analogues.

    更新日期:2020-09-15
  • Bambusicolasides VII and VIII, Two New Glucosides from the Bamboo Aphid Pseudoregma bambusicola
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Puzhao Zhang, Shao Feng, Yamei Zhang

    Two new glucosides, bambusicolasides VII (1) and VIII (2), were isolated from the ethanolic extract of the bamboo aphid Pseudoregma bambusicola. The structures of the two glucosides were identified as 7-O-[2-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-2,5-dimethylchromone (1) and 1,3-di-(O-β-D-glucopyranosyl)-6-methyl-7-nitro-8-naphthol (2) on the basis of spectral data as well as chemical methods

    更新日期:2020-09-15
  • Amino-Acid Derivatives of Pyranocoumarins
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    I. V. Krasylov, V. S. Moskvina, S. V. Shilin, V. P. Khilya

    A methodology for synthesizing amino-acid derivatives of pyranocoumarins in three steps using pyranocoumarin oximes as starting compounds was developed. A series of pyranocoumarins containing the amino acids glycine, alanine, phenylalanine, methionine, leucine, and β-alanine in their structures could be prepared using the activated ester method.

    更新日期:2020-09-15
  • Total Synthesis of Cyclic Lipodepsipeptide Ophiotine
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Jing Wang, Chao Liu, Hong-Gang Hu, Yan Zou, Qin-Jie Zhao, Guang-Ming Ye

    The first total synthesis of the natural nematicidal cyclic lipodepsipeptide ophiotine via a convergent strategy that involved both solid-phase peptide synthesis and liquid phase chemistry is reported. The pre-made dipeptide building block was synthesized in the liquid phase, which was then assembled into the peptide backbone through standard Fmoc chemistry on solid support. After cleavage from the

    更新日期:2020-09-15
  • Two New Coumarins from the Roots and Stems of Nicotiana tabacum and their Bioactivity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-15
    Li-Jun Zhu, Dian Luo, Na Lv, Yin-ke Li, Qi-Li Mi, Jin Wang, Wei-Song Kong, Qian Gao, Gan-Peng Li, Guang-Yu Yang, Qiu-Fen Hu, Ying Guan, Yan-Qing Ye

    Two new coumarins, 6-hydroxymethyl-3-prenyl-7-methoxycoumarin (1) and 6-hydroxyethyl-3-prenyl-7- methoxycoumarin (2), together with three known coumarins (3–5), were isolated from the roots and stems of Yunyan-300, a variety of Nicotiana tabacum L. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-methicillinresistant

    更新日期:2020-09-15
  • A New Monoterpene-Flavanone Conjugate from the Aerial Parts of Chimonanthus grammatus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    Yuxian Li, Ke Sun, Lin Liang, Man Wang, Zhenliang Sun

    A new monoterpene-flavanone conjugate, grammatin A (1), along with four known compounds (2–5), were isolated from the aerial parts of Chimonanthus grammatus. Their structures were elucidated through extensive analysis of NMR spectroscopic data in combination with the reported literature. All these compounds were isolated from this plant for the first time.

    更新日期:2020-09-14
  • A New Coumarin from the Bark of Cryptocarya bracteolata
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    Nurdin Saidi, Khalijah Awang, Mustanir Yahya

    Isolation of compounds from the bark of Cryptocarya bracteolata yielded a new coumarin, 6,7,8-trimethoxy-3,4-dihydrocoumarin. The structure of the compound was elucidated from spectral data, including IR, UV, 1D NMR (13C, 1H, and DEPT), 2D NMR (HMQC, HMBC, and COSY), EI-MS, and ESI-MS techniques.

    更新日期:2020-09-14
  • A New Furan Derivative from Harposporium sp. YMF1.01735
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    Qiao-Mei Zheng, Sisommay Souvanhnachit, Xin Wang, Guo-Hong Li

    The chemical constituents of the endoparasitic fungus Harposporium sp. YMF1.01735 were studied. A new furan harposporin A (1) with a known aureonitol (2) were isolated and identified from the EtOAc extract of the strain. Their structures were elucidated by NMR and MS analysis. This is the first report on the chemical constituents of the genus Harposporium.

    更新日期:2020-09-14
  • New Flavonoid Glycoside from Thalictrum minus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    B. D. Komilov, M. A. Agzamova, I. M. Isaev, K. A. Eshbakova

    The new flavonoid diglycoside thamiflaside was isolated from the aerial part of Thalictrum minus. The chemical structure of this glycoside was determined as apigenin 7-O-α-L-2″′-methoxyrhamnopyranosyl-(1→6)-β-D-glucopyranoside based on PMR and 13C NMR (DEPT, HSQC, HMBC) physicochemical methods.

    更新日期:2020-09-14
  • Isolation and Cytotoxicity of Isocoumarins from the Entomogenous Fungus Setosphaeria sp.
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-14
    Sha-Sha Liu, Wen-Bin Gao, Jie Kang, Xiao-Hui Yang, Fei Cao, Fan-Dong Kong, You-Xing Zhao, Du-Qiang Luo

    A new isocoumarin compound named setosphacohol A (1), together with six known ones, alternariol (2), isoaltenuene (3), phomasatin (4), alternariol 5-O-methyl ether (5), 1-deoxyrubralactone (6), and rubralactone (7), was isolated from the entomogenous fungus Setosphaeria sp. The structure of the new compound was elucidated by analysis of the 1D and 2D spectroscopic data as well as MS. Compounds 2, 5

    更新日期:2020-09-14
  • Synthesis of Several Cytisine Derivatives and their Cytotoxicities against A431, A375, and HCT 116 Tumor Cell Lines
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    P. R. Petrova, A. V. Koval′skaya, I. P. Tsypysheva, A. S. Bunev

    Cytotoxicities of the quinolizidine alkaloid (–)-cytisine and 19 of its derivatives with substituents in the 3-, 9-, and 11-positions were assessed against A431 (epidermal carcinoma), A375 (melanoma), and HCT 116 (colorectal carcinoma) tumor cell lines using the MTT assay (etoposide reference drug). Practically all synthesized compounds at a concentration of 30 μM possessed slight ability to inhibit

    更新日期:2020-09-12
  • New Sesquiterpene Lactone from Inula britannica
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    D. E. Dusmatova, K. K. Turgunov, Kh. M. Bobakulov, R. F. Mukhamatkhanova, I. D. Sham’yanov, B. Tashkhodzhaev, N. D. Abdullaev

    A new sesquiterpene lactone that was called inulonolide was isolated from Inula britannica. Its structure was established as 2-keto-1β,10β-epoxy-5,7,8,11α(H)-guai-3-en-8,12-olide based on spectral data and an X-ray crystal structure analysis.

    更新日期:2020-09-12
  • Chemical Composition of Flowers of Yucca elephantipes Cultivated in Georgia
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    E. P. Kemertelidze, M. M. Benidze, V. G. Nebieridze, A. V. Skhirtladze, M. Ganzera

    Three sesquiterpene glycosides, i.e., nerolidol derivatives, and steroidal glycosides of the 3-furostanol and 1-spirostanol series, one of which was new and characterized as (25R)-26-O-β-D-Glcp-5α-furostan-3β,22α,26-triol 3-O-β-D-Xylp-(1→3)-[O-β-D-Glcp-(1→3)-O-β-D-Glcp-(1→2)]-O-β-D-Glcp-(1→4)-O-β- D-Galp, were isolated from flowers of Yucca elephantipes Regel cultivated in Georgia. The structures of

    更新日期:2020-09-12
  • Methylation of Quercetin by Diazomethane and Hypoglycemic Activity of its Tetra- O -Methyl Ether
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    E. R. Karimova, L. A. Baltina, L. V. Spirikhin, T. A. Sapozhnikova, S. F. Gabdrakhmanova, N. S. Makara

    The tetra-O-methyl ether of quercetin (QU) 3 (54%), 3,7,4′-tri-O-methyl ether 4 (30%), and a previously unreported 3,7,3-tri-O-methyl ether of QU 5 (7%) were obtained via methylation of QU by an excess of diazomethane in dioxane. Their structures were established using 2D NMR (1H–1H COSY, 1H–1H NOESY, 1H–13C HSQC, 1H–13C HMBC). Tetra-O-methyl ether of QU 3 exhibited pronounced hypoglycemic activity

    更新日期:2020-09-12
  • A New Phenanthraquinone from the Aerial Parts of Cremastra appendiculata
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-09-12
    Yu-Peng Li, Ya-Ping Chen, Ya-Ting Shao, Yong-Sheng Tao, Rong-Ping Zhang

    A new phenanthraquinone, 2,6-dihydroxy-8-methoxy-1,4-phenanthraquinone (1), was isolated from the aerial parts of Cremastra appendiculata. The structure of the new compound was determined on the basis of NMR (1D and 2D) and mass spectroscopic analysis.

    更新日期:2020-09-12
  • Hypolipidemic Lactone Derivatives from Highland Barley Monascus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-28
    Rongrui Wei, Qinge Ma

    A new lactone, named 9-allyl-5-methyl-1H-difuro-isochromene-1,8-dione (1), together with nine known lactone derivatives (2–10), was isolated from highland barley Monascus for the first time. Compounds 1–10 were studied by spectroscopic methods and comparison with references and evaluated for their hypolipidemic activities by measuring the triglyceride content in HepG2 cells with simvastatin as positive

    更新日期:2020-07-28
  • A New Sesquiterpene Lactone from Eupatorium chinense and its Anti-TNBC Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-28
    Qing-li Jiang, Pan-ting Shou, Min-juan Sun, Guan-feng Wang, Neng-ming Lin, Hua-jun Zhao, Bo Yang

    A new sesquiterpene lactone, namely, eupachiilide A (1), as well as two known sesquiterpene lactones, eupachinilide B (2), and eupalinilide G (3), were isolated from the whole plant of Eupatorium chinense L. The new structure was elucidated by spectral methods, especially 2D NMR techniques. The three natural compounds were all Michael addition acceptors, whose electrophilic moiety could react with

    更新日期:2020-07-28
  • A New Dimeric Lignan from Machilus philippinensis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-28
    C. Y. Chen, C. T. Chen, S. L. Liu, C. L. Kao, W. J. Li, H. C. Yeh, H. T. Li, H. W. Chang

    A new dimeric lignan, machiphilippin (1), was isolated from the stems of Machilus philippinensis Merr. (Lauraceae). The structure of the new dimeric lignan was elucidated by chemical and physical evidence.

    更新日期:2020-07-28
  • Synthesis and Antioxidant Activity Evaluation of Trolox Derivatives
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-28
    Qian Xu, Luyun Zhang, Dazhao Zhan, Guangqing Xia, Junyi Zhu, Hao Zang

    To find potent antioxidants, 16 novel Trolox derivatives were designed and synthesized via a reduction and esterification reaction. The chemical structures were characterized by NMR and MS. Trolox derivatives were employed to explore the potential structure–antioxidant activity relationships using three different assays. The results revealed that some of the synthesized compounds exhibited stronger

    更新日期:2020-07-28
  • Two New Oleanane Triterpenoids from Syzygium samarangense
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-27
    Yi-Kao Hu, Li Wang, Yan Zhao, Jing-Ping Liu, Ji-Hua Wang, Yong Zhao

    Two new oleanane triterpenoids, sysamarins F (1) and G (2), along with one known analogue (3), were isolated from the leaves of Syzygium samarangense. Their structures were elucidated by means of extensive spectroscopic techniques, including interpretation of 1D and 2D NMR spectra and comparison with the values reported in the literature.

    更新日期:2020-07-27
  • Rearrangement of Epoxide Derivatives Semisynthesized from β -Himachalene using Lewis and Bronsted Acids Catalysis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-27
    Mohamed Dakir, Mustapha Ait Elhad, Abdelouahd Oukhrib, Noureddine Mazoir, Ahmed Benharref

    The acid-catalyzed rearrangement of epoxides 3a, 4a, 6a, and 7a derived from β-himachalene, the major constituent of Cedrus atlantica essential oil, has been studied using various Lewis and Bronsted acids. Several new enantiomerically pure ketones were obtained in good yields and high selectivities. All products obtained were fully characterized by 1H and 13C NMR, and the mechanistic explanations for

    更新日期:2020-07-27
  • Correction to: Chemical Constituents of Zanthoxylum bungeanum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    Bing-Qiang Zhu, Jing-Fan Yang, Tong-Tong Song, Xiao-Fei Li, Tao Guo, Li-Li Wang, Ya Wang, Jun Chang

    To the article “Chemical Constituents of Zanthoxylum bungeanum,” by Bing-Qing Zhu, Jing-Fan Yang, Tong-Tong Song, Xiao-Fei Li, Tao Guo, Li-Li Wang, Ya Wang, and Jun Chang, Vol. 56, No. 1, pp. 164–165, January, 2020.

    更新日期:2020-07-26
  • Phenolic Constituents of Syzygium austroyunnanense
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    Feng Li, Meng-Jia Li, Yi-Kao Hu, Jing-Ping Liu, Ding-Li Zhang, Yong Zhao

    Twelve phenolic compounds, including one new phloroglucinol derivative, were isolated from the leaves of Syzygium austroyunnanense. Their structures were elucidated based on the spectroscopic data and by comparison with the literature. All of compounds were firstly isolated from this species.

    更新日期:2020-07-26
  • A New Phenolic Glycoside from the Seeds of Moringa oleifera
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    Min-Min Tang, Guang-Ying Chen, Kun-Chi Jiang, Ming-Yue Luo, Hao Wu, Bing Hu, Xue-Ming Zhou

    A new phenolic glycoside derivative, moringapyranosyl (1), along with five known phenolic glycoside derivatives (2–6), was isolated from the seeds of Moringa oleifera. Their structures were identified by spectroscopic analyses and by comparison of their spectral data with those reported in the literature. The inhibitory activities of all compounds against α-glucosidase were evaluated. Compounds 1–6

    更新日期:2020-07-26
  • A New Apocarotenoid of Cinnamomum burmannii
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    R. J. Lin, C. L. Kao, S. L. Liu, H. C. Yeh, P. L. Song, H. T. Li, H. M. Wang, H. W. Chang, C. Y. Chen

    A new apocarotenoid, burmannic acid (1), was isolated from the roots of Cinnamomum burmannii (Nees & T. Nees) Blume (Lauraceae). The structure of the new apocarotenoid was elucidated by chemical and physical evidence.

    更新日期:2020-07-26
  • Indole Alkaloids from Vinca erecta , Structure and Stereochemistry
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    B. Tashkhodzhaev

    Stereochemical and structural aspects of series of indoline, α-methyleneindoline, indolenine, indole, and 2-oxoindoline alkaloids. The stereochemistry of the molecules is analyzed. The descriptors of the chiral centers of indole alkaloids from Vinca erecta are determined.

    更新日期:2020-07-26
  • Synthesis and Analgesic Activity Assessment of Furanolabdanoid Conjugates with Glucuronic Acid
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-26
    O. I. Brusentseva, Yu. V. Kharitonov, M. P. Dolgikh, T. G. Tolstikova, E. E. Shul’ts

    Phlomisoic acid reacted with methyl-1-deoxy-2,3,4-tri-O-acetyl-1-bromo-α-D-glucopyranuronate to form the 18-O-β-D-(glucuronopyranoside)-6′-O-methyl ester of 15,16-epoxylabda-8(9),13,14-triene. Reductive amination of methyl 16-formyl-15,16-epoxylabda-8(9),13,14-trienoate or this β-D-glucuronopyranoside of 16-formyl-15,16-epoxylabda-8(9),13,14-triene by propargylamine in the presence of NaBH4 gave the

    更新日期:2020-07-26
  • A New 27-Norcucurbitane Triterpenoid from the Fruits of Momordica charantia var. abbreviata
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-25
    Chiy-Rong Chen, Yun-Wen Liao, Jue-Liang Hsu, Yun-Sheng Lin, Chi-I Chang

    A new 27-norcucurbitane triterpenoid, 5β,19-epoxy-3β-hydroxy-19(R)-methoxy-27-norcucurbita-6,23(E)-dien-25-one (1), was isolated from the fruits of Momordica charantia var. abbreviata. Its structure was elucidated by spectroscopic analyses including 1D and 2D NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and comparison with the data of known analogues.

    更新日期:2020-07-25
  • Synthesis of New Exocyclic Allenes with Diterpene Fragments
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-25
    I. M. Sakhautdinov, R. N. Malikova

    New stable allenes with exocyclic cumulene groups were synthesized from N-maleopimarimide-substituted amino acids using phenyl(triphenylphosphoranylidene)succinimide, 2-fluorophenyl(triphenylphosphoranylidene)-succinimide, and benzyl(triphenylphosphoranylidene)succinimide.

    更新日期:2020-07-25
  • Cytotoxic Hydroperoxycochliodinol Derivative from Endophytic Chaetomium sp. Isolated from Salvia officinalis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-07-25
    Siham Mallouk, Naglaa Salah El-Deen Mohamed, Abdessamad Debbab

    The endophytic fungus Chaetomium sp. was separated from the medicinal plant Salvia officinalis growing in Egypt and cultivated on solid rice medium. Chemical investigation of the EtOAc extract yielded a new hydroperoxycochliodinol derivative (1) in addition to several known compounds, which included cochliodinol (2), isocochliodinol (3), chaetomin (4), and two simple indole derivatives (5, 6). The

    更新日期:2020-07-25
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