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  • A Novel Spermidine Macrocyclic Alkaloid from the Roots of Tripterygium wilfordii
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-06
    Jianqun Liu, Qiushan Wu, Jicheng Shu, Rui Zhang, Lifang Liu

    A novel 13-membered spermidine macrocyclic alkaloid, (2R)-9-furoyl-2-phenyl-1,5,9-triazacyclotridecane-4,13-dione, named celacarfurine (1), was isolated from the roots of Tripterygium wilfordii. Its structure has been elucidated on the basis of NMR and MS data. To the best of our knowledge, 13-membered spermidine macrocyclic alkaloids were rarely reported natural products; moreover, the known ones

    更新日期:2020-06-06
  • Synthesis and Cytotoxicity of 28-Oxo-Allobetulone Derivatives
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-06
    E. F. Khusnutdinova, I. E. Smirnova, O. B. Kazakova

    28-Oxo-allobetulone derivatives that were newly synthesized or prepared earlier by modification of ring A (3- and 4-pyridylidene, furfurylidene, azepane, lactam, quinolone, spiroindole, pyrazole, isoxazole, and tetraoxane derivatives) and 3β,19β,28-oleantriol were tested in vitro for cytotoxicity against 60 cell lines of 9 human tumor types. Melanoma SK-MEL-5 and CNS SNB-75 cancer cells died in the

    更新日期:2020-06-06
  • Synthesis from Δ 3 -Carene of Optically Active Macrolides with Fragments of Di- and Triethyleneglycol and Hydrazides of Dicarboxylic Acids
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-06
    M. P. Yakovleva, K. S. Denisova, G. R. Mingaleeva, Yu. V. Myasoedova, L. R. Garifullina, N. M. Ishmuratova, G. Yu. Ishmuratov

    Efficient syntheses of six potentially useful optically pure macroheterocycles with ester and dihydrazide fragments were developed from available natural Δ3-carene through intermediate (31R,33S)-32,32-dimethyl-3(1,3)cyclopropyla-5-oxohexanoic acid using in the key steps [2+1]-reactions of the last with di- or triethylene glycol and [1+1]-condensation of the resulting α,ω-diketodiesters with several

    更新日期:2020-06-06
  • A New Triterpenoid Saponin from Camellia oleifera Fruit Hull
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    Lei Wu, Guo-Qun Li, Zhen Gu, Jian-Ping Fu, Zi-Jiang Li, Jie Zhang, Wei Xiong, Guang-Qiang Ma, Young-Soo Bae

    A new triterpene saponin (1), along with oleanolic acid 3-O-β-D-glucopyranoside (2), were isolated from the fruit shells of Camellia oleifera Abel. The structure of 1 was determined to be 3-O-β-Dglucopyranosyl( 1"→6')α-L-rhamnosyl 27-hydroxyoleanolic acid-28-O-β-D-glucopyranoside, which was established by analyses of their 1H and 13C NMR spectra with the aid of 2D experiments.

    更新日期:2020-06-05
  • Acutinine – A New Quinolin-2-One Alkaloid from Haplophyllum acutifolium
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    M. A. Eshonov, Kh. A. Rasulova

    The new base acutinine and the known alkaloids skimmianine, evoxine, glycoperine, perfamine, and haplamine were isolated from total alkaloids from the aerial part of Haplophyllum acutifolium collected in Jizzakh Oblast, Republic of Uzbekistan. Acutinine was identified as a quinolin-2-one derivative based on spectral characteristics.

    更新日期:2020-06-05
  • Diterpenoid Alkaloids from the Roots of Aconitum iochanicum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    Jiang Hu, Yan Lv, Qiang Li, Xia Mao, Tianfeng Peng, Xiu Gao, Nianhua Jin, Si Yin, Xiaodong Shi, Wei Wang

    Three new diterpenoid alkaloids, namely 1-N-deethyl-1,16-demethoxy-1,16-dihydroxy-N(19)-enaustroconitine A (1), 1-N-deethyl-1,16-demethoxy-1,16-dihydroxy-18-methoxy-N(19)-en-austroconitine A (2), and 1-N-deethyl-1,16-demethoxy-1,16-dihydroxyranaconidine (3), were isolated from the 80% ethanol extract of the roots of Aconitum iochanicum. Structural elucidation of all the compounds was performed by spectral

    更新日期:2020-06-05
  • New Arteannuin B Derivatives and Their Cytotoxic Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    S. G. Klochkov, M. E. Neganova, S. A. Pukhov, S. V. Afanas’eva, Yu. R. Aleksandrova, E. Yu. Yandulova

    Previously unknown conjugates of the natural sesquiterpene lactone arteannuin B, which was isolated from Artemisia annua, were synthesized via Michael reactions with pharmacophoric amines and tested in vitro for cytotoxic activity. The compounds were shown to exhibit antiproliferative properties for various tumor cell lines. The most active derivatives had IC50 values of 8–36 μM, which exceeded that

    更新日期:2020-06-05
  • Synthesis of Derivatives of the 2-Arylquinoline Alkaloid Dubamine and their Cytotoxicity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-05
    A. R. Niyazmetov, E. O. Terent’eva, U. B. Khamidova, Z. S. Khashimova, Sh S. Azimova, V. I. Vinogradova

    5′-Nitro- (2) and 5′-aminodubamine (3) were sequentially synthesized from the alkaloid dubamine. Condensation of 3 with 15 aldehydes gave imines, reduction of which produced secondary amines. Studies of the cytotoxicities for HeLa and HEp-2 cells of the compounds at a concentration of 100 μM revealed several trends. The activity decreased significantly or disappeared at lower concentrations although

    更新日期:2020-06-05
  • A New Tetracyclic Triterpenoid from the Fresh Bark of Ailanthus altissima
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Tian-Hui Zhu, Yu-Fang Wang, Mei Dong, Francoise Sauriol, Chang-Hong Huo, Yu-Cheng Gu, Zhi-Yu Ni

    A new tetracyclic triterpenoid (1) was isolated from the fresh bark of Ailanthus altissima. The structure was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques and high-resolution mass spectrometry.

    更新日期:2020-06-04
  • A New 2 H -pyran from Michelia compressa var. Lanyuensis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    S. L. Liu, Y. S. Tsai, C. T. Chen, H. C. Yeh, C. Y. Chen

    Pressalanin B (1), (–)-anonaine (2), (–)-asimilobine (3), (–)-N-acetylanonaine (4), liriodenine (5), stearic acid (6), 6β-hydroxystigmast-4-en-3-one (7), 6β-hydroxystigmast-4,22-dien-3-one (8), costunolide (9), 11,13-dehydrolanuginolide (10), N-trans-feruloyltyramine (11), N-trans-caffeoyltyramine (12), N-cis-caffeoyltyramine (13), p-hydroxybenzoic acid (14), p-hydroxybenzaldehyde (15), methylparaben

    更新日期:2020-06-04
  • A New Diterpene from Dysoxylum lukii
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Pu-zhao Zhang, Ya-mei Zhang

    A new diterpene, dysokusone G (1), was isolated from the stems of Dysoxylum lukii Merr., along with twelve known compounds, which were reported for the first time from this plant. The structures were elucidated using spectroscopic methods and by comparison with published NMR spectroscopic data.

    更新日期:2020-06-04
  • A New Sesquiterpene from Dendranthema grandiflora Flowers
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Consolacion Y. Ragasa, Madeleine Si, Maria Carmen S. Tan, Deanne Hazel Pelobello, Ming-Jaw Don, Chien-Chang Shen

    Chemical investigation of the dichloromethane extracts of the flowers of Dendranthema grandiflora cv. Yoko Ono afforded a new sesquiterpene lactone, grandiflorolide (1), 1,2-dilinoleoyl-3-linolenoylglycerol (2), a mixture of pseudotaraxasterol (3a), taraxasterol (3b), β-amyrin (3c), α-amyrin (3d), and lupeol (3e) in about 2:1:1:0.5:0.5 ratio, and another mixture of β-sitosterol (4a) and stigmasterol

    更新日期:2020-06-04
  • Two New Isoquinoline Alkaloids from Whole Plants of Thalictrum glandulosissimum and their Anti-TMV Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Qiu-Fen Hu, Ling-Min Liao, Hai-Tao Huang, Yong Xu, Jin Wang, Wei-Song Kong, Qi-Li Mi, Min Zhou, Guang-Yu Yang, Chun-Man Song

    Two new isoquinoline alkaloids, 3-hydroxy-1-(7-hydroxy-6-methylisoquinolin-1-yl)propan-1-one (1) and 3-hydroxy-1-(7-methoxy-6-methylisoquinolin-1-yl)propan-1-one (2) were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus

    更新日期:2020-06-04
  • A New α -Ionone from Michelia champaca
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    S. L. Liu, C. L. Kao, H. C. Yeh, P. L. Song, H. T. Li, C. Y. Chen

    A new α-ionone, (Z)-4-hydroxy-3,5,5-trimethyl-4-(3′-oxobut-1′-enyl)cyclohex-2-enone (1) was isolated from the flower of Michelia champaca L. The structure of the new α-ionone was elucidated by chemical and physical evidence.

    更新日期:2020-06-04
  • Phenylethanoid Glycosides from Callicarpa nudiflora
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Xiao-Jie Yan, Gu Zhi-Xin, Pan Zheng-Hong, Ning De-Sheng, Sheng Huang, Jin-Lei Liu, Dian-Peng Li

    A new phenylethanoid glycoside, named cis-alyssonoside (1), was isolated from the leaves of Callicarpa nudiflora, along with four known phenylethanoid glycosides (2–5). Their structures were determined on the basis of extensive spectroscopic analysis and comparison with literature data. The inhibitory effects on lipopolysaccharide induced nitric oxide (NO) production in RAW264.7 cells of all the compounds

    更新日期:2020-06-04
  • A New Isopimarane Diterpenoid from Cultures of Inonotus sinensis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    Jian-Hai Ding, Zheng-Hui Li, Tao Feng, Ji-Kai Liu

    A new isopimarane diterpenoid, inonotolide D (1), was isolated from cultures of the basidiomycetes Inonotus sinensis. The new structure was elucidated on the basis of extensive spectroscopic studies. The compound was evaluated for its cytotoxicities against five human cancer cell lines.

    更新日期:2020-06-04
  • ortho -Methoxybenzoyl-Derivatives of Ecdysteroids
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-04
    I. D. Bobaev, Kh. M. Bobakulov, M. M. Makhmudova, N. D. Abdullaev

    Four new o-methoxybenzoyl esters of ecdysteroids were prepared by reacting 2-deoxy-α-ecdysone, 20-hydroxyecdysone, turkesterone, and cyasterone with methoxybenzoyl chloride. The structures of the ecdysteroid derivatives were established using NMR spectroscopy.

    更新日期:2020-06-04
  • New Fatty Acid Derivative from the Stem Bark of Cassia grandis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    Quoc Luan Ngo, Nhat Minh Phan, Tan Phat Nguyen

    For the first time, the n-hexane extract from the dried stem bark of Cassia grandis L.f. was investigated, and one new fatty acid derivative, named casgraester A (1), was obtained, together with three known ones, 2,3-dihydroxypropyl 28-hydroxyoctacosanoate (2), 2,3-dihydroxypropyl octacosanoate (3), bis-(2,3-dihydroxypropyl)tetracosanedioate (4), three known triterpenoids, lupeol (5), betulinic acid

    更新日期:2020-06-03
  • A Sesquiterpene Lactone from Irpex lacteus
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    Jian-Hai Ding, Zheng-Hui Li, Tao Feng, Ji-Kai Liu

    A new tremulane sesquiterpene lactone, named irlactin K (1), was isolated from the culture broth of the basidiomycete Irpex lacteus. The structure of the new compound was established through extensive spectroscopic analyses. The compound was tested for its cytotoxicity against five human cancer cell lines and for its inhibitory activity against isozymes of 11β-hydroxysteroid dehydrogenases.

    更新日期:2020-06-03
  • Synthesis of 7-Hydroxy-8-Methyl-4 ' -Methoxy-6-Formylisoflavone and Linear Hetarenochromones Based on It
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    T. V. Shokol, N. V. Gorbulenko, M. S. Frasinyuk, V. P. Khilya

    7-Hydroxy-8-methyl-4'-methoxy-6-formylisoflavone was synthesized from the 6-aminomethyl derivative of 7-hydroxychromone under modified Duff reaction conditions and underwent heterocyclization to form linear furo- and pyranochromones.

    更新日期:2020-06-03
  • Two 1,2-Seco-Coumarins from Clausena lansium
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    Wenwen Peng, Xiaoxiang Fu, Yuyan Li, Guanghua Huo, Baotong Li

    A new 1,2-seco-furan-coumarin, claulancoumarin A (1), and a known 1,2-seco-coumarin, (Z)-2,4-dihydroxycinnamic acid (2), were isolated from the branches and leaves of Clausena lansium. Their structures were elucidated by spectroscopic analysis, including NMR and MS.

    更新日期:2020-06-03
  • Two New Compounds from Empetrum nigrum var. japonicum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    Biao Bai, Qing-hu Wang, Mei-li Wang, Qilemuge Wang

    Two new compounds, 3',5'-dimethyl-4',6'-dimethoxy-2'-hydroxydihydrochalcone (1) and 3',5'-dimethyl-6'- methoxy-2',4'-dihydroxydihydrochalcone (2), were isolated from the CHCl3 extract from Empetrum nigrum L. var. japonicum K. Koch. Their structures were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR techniques.

    更新日期:2020-06-03
  • A New Diester from the Flowers of Michelia fuscata
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    S. L. Liu, C. L. Kao, J. Y. Pan, H. T. Li, C. Y. Chen

    Fuscatin A (1), liriodenine, (–)-anonaine, N-methylcorydaldine, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, vanillic acid, isovanillin, β-sitosterol, stigmasterol, 11,13-dehydrolanuginolide, and costunolide were isolated from the flowers of Michelia fuscata (Magnoliaceae). Among them, fuscatin A is a new diester. The structures of these compounds were characterized and identified by spectral analyses

    更新日期:2020-06-03
  • A New Chromene Derivative from Alternaria sp. ZG22
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    Xin-Ming Song, Juan-Juan Luo, Ya-Ling Li, Li-Bing Huang, Cai-Cui Chen, Zi-Wei Ma, Bing Chen, Xue-Ming Zhou, Xiao-Ping Song, Chang-Ri Han

    A new chromene derivative, alternapyran (1), along with three known compounds (2–4), was isolated from the Alternaria sp. ZG22 obtained from a Dasymaschalon rostratum collected from the Hainan. The structure of the new compound 1 was elucidated by NMR and mass spectroscopic data. Compounds 2 and 3 showed broad spectrum antibacterial activity against four terrestrial pathogenic bacteria.

    更新日期:2020-06-03
  • New Metabolite from the Endophytic Fungus Corynespora smithii
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    Yung-Shun Su, Ming Jen Cheng, Ming Der Wu, Sung Yuan Hsieh, Chee-Yin Chai, Aij-Li Kwan

    A new isopimarane-type diterpene glycoside, named hypomonticuside (1), was isolated from the BuOH-soluble fraction of the liquid fermentation of an endophytic fungus Corynespora smithii, derived from the stems of Ardisia cornudentata Mez (Myrsinaceae). The structure of 1 was elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR techniques.

    更新日期:2020-06-03
  • α - and γ -Apienes, Ferovinal, and Ferocin from Ferula ovina
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    Kh. I. Khasanova, K. A. Eshbakova, K. K. Turgunov, B. Tashkhodzhaev, H. A. Aisa

    The esters ferovinal (α-apiene-type) and ferocin (γ-apiene-type) were isolated from Ferula ovina. Their structures were established by analyzing IR, PMR, and 13C NMR spectra; DEPT, HSQC, COSY, NOESY, and HMBC experiments; and X-ray crystal structure analyses (XSAs). The XSAs determined the molecular structures and absolute configurations of ferovinal and ferocin and established that their 11-membered

    更新日期:2020-06-03
  • A New Dihydroagarofuranoid Sesquiterpene and Cytotoxic Constituents of Microtropis fokienensis
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    Chien-Ming Huang, Ping-Jyun Sung, Yueh-Hsiung Kuo, Tsung-Hsien Chang, Chun-Lin Chen, Ming-Jen Cheng, Jih-Jung Chen

    A new dihydroagarofuran sesquiterpene polyester, fokienagarofuran J (1), has been isolated from the roots of Microtropis fokienensis, together with six known compounds, 2,6-dimethoxy-p-benzoquinone (2), β-sitostenone (3), 6β-hydroxystigmast-4-en-3-one (4), celahin C (5), salasol A (6), and fokienagarofuran D (7). The structure of the new compound 1 was determined through spectroscopic and MS analyses

    更新日期:2020-06-03
  • Isoquinoline Alkaloids from Whole Plants of Thalictrum cirrhosum and Their Antirotavirus Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-06-03
    Dian Luo, Na Lv, Li-Jun Zhu, Ling-Min Liao, Yong Xu, Jin Wang, Wei-Song Kong, Hai-Tao Huang, Min Zhou, Guang-Yu Yang, Qiu-Fen Hu, Xiao-Xi Si

    Two new (1 and 2), together with two known (3 and 4), isoquinoline alkaloids were isolated from the whole plants of Thalictrum cirrhosum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were tested for their antirotavirus activity. The results revealed that compounds 2 exhibited high antirotavirus activity with a therapeutic index

    更新日期:2020-06-03
  • Synthesis and Cytotoxicity of Epiandrosterone Hydrazones
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-04-04
    N. Sh. Nadaraia, N. N. Barbakadze, V. D. Mshvildadze, B. Sylla, J. Legault, A. Pichette

    Two series of hydrazones were synthesized from 3β-hydroxy- and 3β-(1-adamantoate)-5α-androstan-17- one, respectively, to study the structure–activity relationship. Cytotoxicity studies showed that 5α-androstan- 3β-ol-17-one m-nitrobenzoylhydrazone exhibited pronounced specific activity in a Hoechst experiment against lung carcinoma (A-549) and colorectal adenocarcinoma cell lines (DLD-1).

    更新日期:2020-04-20
  • Flavonoids from Herb of Monarda fistulosa
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-04-01
    V. A. Kurkin, A. S. Lapina, E. D. Daeva, V. I. Kadentsev

    Monardoside (apigenin 5-O-rutinoside), which was a new natural compound, isorhoifolin (apigenin 7-O-rutinoside), linarin (acacetin 7-O-rutinoside), and didymin (isosacuranetin 7-O-rutinoside) were isolated and characterized from the herb of Monarda fistulosa L. using PMR, 13C NMR, and UV spectroscopy, mass spectrometry, and chemical transformations.

    更新日期:2020-04-20
  • New Steroidal Glycosides from Pericarps of Digitalis ciliata
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-04-01
    E. P. Kemertelidze, M. M. Benidze, V. G. Nebieridze, A. V. Skhirtladze, Markus Ganzera

    Pericarps of Digitalis ciliata Trautv. yielded 12 steroidal compounds, three of which were new, i.e., two furostanol and one spirostanol glycosides.

    更新日期:2020-04-20
  • A New Isocoumarin from the Fungus Xylaria mali
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-04-01
    Ming-Jen Cheng, Ming-Der Wu, Thanda Aung, Chiao-Tang Chang, Sung-Yuan Hsieh, Jih-Jung Chen

    A new isocoumarin, xylariamalirin (1), was isolated from the n-BuOH-soluble fraction of the fermentation broth of an endophytic fungus Xylaria mali, derived from the Taiwanese Lepidagathis stenophyllTaiwana C. B. Clarke ex Hayata (Acanthaceae) growing in the Hengchun Peninsula of southern . The structures were elucidated by spectroscopic analyses, including 1D and 2D NMR experiments, and by HR-ESI-MS

    更新日期:2020-04-20
  • Transformations of Peroxide Products from Ozonolysis of (–)- α -Pinene and (+)-3-Carene by Capric and Benzoic Acid Hydrazides
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-04-01
    Yu. V. Myasoedova, L. R. Garifullina, E. R. Nurieva, N. M. Ishmuratova, G. Yu Ishmuratov

    Reduction of the peroxide ozonolysis products of (–)-α-pinene and (+)-3-carene by capric and benzoic acid hydrazides in CH2Cl2 or THF produced diacylhydrazones either pure or mixed with the corresponding ketoacids. The capric acid diacylhydrazone formed primarily in CH2Cl2; benzoic acid diacylhydrazone, in THF. The only reaction products formed in MeOH were the corresponding ketoesters.

    更新日期:2020-04-20
  • A New Anticancer Bisflavan-3-Ol from Boerhavia elegans
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-04-01
    Najeeb Ur Rehman, Hidayat Hussain, Husain Yar Khan, Ghulam Abbas, Hidayatullah, Ahmed Al-Harrasi

    A new a bisflavan-3-ol, boerhavianane (1), was isolated from Boerhavia elegans L. The structure of the flavanol dimer was elucidated by detailed spectroscopic analysis including 1H, 13C NMR, COSY, HMQC, HMBC, and ESI-MS. Boerhavianane (1) was evaluated for its anticancer activity and demonstrated a significant reduction in the viability of breast cancer cells in a concentration-dependent manner with

    更新日期:2020-04-20
  • A New Phenolic Glycoside from Viburnum Melanocarpum Fruits and its α -Glucosidase Inhibitory Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-04-01
    Zi-Yang Zhao, Jia Chen, Jie Shen, Jian-Hua Shao, Xu-Hua Huang, Chun-Chao Zhao

    A new phenolic glycoside 1, together with its enantiomer (2), was isolated from the ethanolic extract of Viburnum melanocarpum P. S. Hsu fruits by repeated column chromatography. Its structure was identified as (7R,8S)-guaiacylglycerol 4-O-β-D-(6-O-vanilloyl)glucopyranoside (1) by spectroscopic data (1H NMR, 13C NMR, HSQC, HMBC, and ORD) and chemical methods. In the intestinal α-glucosidase inhibitory

    更新日期:2020-04-01
  • Fatty Acid, Sterol, and Tocol Compositions; Amino Acid, Mineral, Total Phenolic, and Flavonoid Contents; and Antioxidant Activity of Seeds of Two Vincetoxicum Taxa
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-04-01
    S. Guzel

    The fatty acid, sterol, and tocol compositions; total phenolic, total flavonoid, amino acid, and mineral contents; and antioxidant activity of Vincetoxicum canescens subsp. canescens and V. canescens subsp. pedunculata (endemic) seeds were examined. Seeds were rich in oleic acid, linoleic acid, β-sitosterol, and α-tocopherol. In V. canescens subsp. canescens lysine and in V. canescens subsp. pedunculata

    更新日期:2020-04-01
  • A New Dimeric Sesquiterpenoid from Capsicum annuum var. conoides
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-03-31
    C. Y. Chen, C. L. Kao, H. C. Yeh, P. L. Song, H. T. Li, W. J. Li

    A new dimeric sesquiterpenoid, conoidol A (1), was isolated from the unripe fruits of Capsicum annuum var. conoides (Mill.) Irish. The structure of the new dimeric sesquiterpenoid was elucidated by chemical and physical evidence.

    更新日期:2020-03-31
  • A New Diarylheptanoid from the Twigs of Quercus Acutissima and their Neuroprotective Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-03-31
    Joon Min Cha, Lalita Subedi, Zahra Khan, Sun Yeou Kim, Kang Ro Lee

    A new diarylheptanoid glycoside, acutissioside A (4), along with five known diarylheptanoids (1–3, 5, 6) was isolated from the twigs of Quercus acutissima Carruth. The structure of the new compound was determined via spectral analysis, including NMR spectra (1H and 13C NMR, 1H–1H COSY, HSQC, HMBC) and HR-ESI-MS, acid hydrolysis, and specific optical rotation data. The neuroprotective effect of all

    更新日期:2020-03-31
  • An Efficient Synthesis of Natural Tribolure
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-03-31
    Jianmin Shi, Lu Liu, Meng Tang, Tao Zhang, Hongjin Bai, Zhenting Du

    An efficient synthesis of natural tribolure has been achieved through an asymmetric methylation as a key step. Natural tribolure is a mixture of four stereoisomers, so racemic 2-methylbutan-1-ol was used as starting material. After a C5+C4 strategy and then a mixed Evan’s template inductive methylation, the key intermediate was obtained. Finally, the natural product tribolure (4:4:1:1 of stereoisomers

    更新日期:2020-03-31
  • Correction to: Anti-Influenza Activity of Several Caryophyllane Thiosesquiterpenoids
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-05
    Yu. V. Gyrdymova, E. O. Sinegubova, A. S. Muryleva, V. V. Zarubaev, S. A. Rubtsova

    In the metadata of the article on SpringerLink the title is incorrect. The title should read Anti-Influenza Activity of Several Caryophyllane Thiosesquiterpenoids

    更新日期:2020-02-06
  • Two New Chromone Derivatives from Cassia nomame and their Anti-Tobacco Mosaic Virus Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-05
    Ling-Min Liao, Yan-Qi Sun, Jing Li, Wei-Song Kong, Xin Liu, Yong Xu, Hai-Tao Huang, Wan-Li Zeng, Qi-Li Mi, Guang-Yu Yang, Qiu-Fen Hu, Yin-Ke Li

    Two new chromone derivatives, 5-(isobutyryl)-2-(2-oxopropyl)-7-methoxy-4H-chromen-4-one (1) and 5-(isobutyryl)-2-(2-oxopropyl)-6-methoxy-4H-chromen-4-one (2), were isolated from Cassia nomame. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed

    更新日期:2020-02-06
  • A New 26-Norlanostanoid from the Fruiting Bodies of Ganoderma philippii
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-05
    Qing-Yun Ma, Shuang Yang, Fan-Dong Kong, Qing-Yi Xie, Li-Man Zhou, Zhi-Fang Yu, You-Xing Zhao

    A new nortriterpenoid, 26-nor-11,22-dioxolanost-8-en-3β,7β,15α-triol (1), was isolated from the EtOAc extract of the fruiting bodies of Ganoderma philippii. Its structure was identified by spectroscopic techniques including 1D and 2D spectral data as well as MS. Compound 1 showed α-glucosidase inhibitory activity with IC50 value of 482.7 μM.

    更新日期:2020-02-06
  • A New Antibacterial Chlorinated Amino Acid Derivative from the Sponge-Derived Fungus Aspergillu s sp. LS53
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-05
    Lu Zhang, Panpan Qiu, Lijian Ding, Qiang Li, Jingjing Song, Zhiwen Han, Shan He

    A new chlorinated amino acid derivative with a rare 3-chloro-4-hydroxyphenyl unit named aspergamide A (1), along with three known compounds, xylarinol A (2), nectriapyrone (3), and asperisocoumarin A (4), were isolated from the sponge-derived fungus Aspergillus sp. LS53. Their structures were determined by combining detailed spectroscopic analysis and literature data. Compounds 1, 3, and 4 showed weak

    更新日期:2020-02-06
  • Alkylation by Polyprenols of ortho - and para -Cresols: Synthesis of Isomeric Polyprenylcresols
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-05
    U. T. Zokirova, N. K. Khidirova, A. A. Koroleva, B. Zh. Elmuradov, A. V. Kuchin, Kh. M. Shakhidoyatov

    Alkylation by polyprenols of o- and p-cresols in the presence of equimolar amounts of the corresponding aluminum cresolates occurred regioselectively to form o-alkyl products regardless of the ratio of starting reagents. Production of 2,6-dipolyprenyl-4-methylphenol was favored if an excess of polyprenols was used with aluminum p-cresolate. A significant amount of polyprenol polymerization products

    更新日期:2020-02-06
  • Synthesis and Cytotoxic Activity of a Series of Functionalized Maleopimarimides
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-05
    R. N. Malikova, I. M. Sakhautdinov, E. O. Terenteva, Z. S. Khashimova, M. S. Yunusov, Sh. S. Azimova

    New functionalized maleopimarimides were prepared. Their cytotoxicity against tumor cell lines (HeLa, HEp-2) was studied. Diterpenoids 6, 9, and 10 with allene fragments possessed the greatest cytotoxicity and could be considered lead compounds with potential antitumor activity.

    更新日期:2020-02-06
  • Structural Characteristics and Anticancer Activity In Vitro of Fucoidans from Brown Seaweeds Sargassum miyabei and S. oligocystum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-04
    V. V. Surits, R. V. Usoltseva, N. M. Shevchenko, P. D. Thinh, S. P. Ermakova

    High-purity fucoidan fractions were obtained from brown seaweeds Sargassum miyabei and S. oligocystum. Both first fractions were mannnogalactofucans; second, galactofucans. Fucoidans from S. miyabei contained acetyls. The isolated polysaccharides were not cytotoxic at concentrations up to 400 μg/mL. Formation and growth of colonies of HT-29 and HCT-116 cells were weakly inhibited by the tested fucoidans

    更新日期:2020-02-04
  • Two New Phenolic Compounds from the Antarctic Lichen Pertusaria dactylina
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-04
    Man Hyung Goo, Ji Hee Kim, Hyun Park, Jun Hyuck Lee, Ui Joung Youn

    Two new phenolic compounds, methyl 2-hydroxy-4-methoxy-6-(2-oxopentyl)-benzoate (1) and 4-methoxy-6-pentyl-1,2-dihydroxybenzene (2), together with two known phenolic derivatives, were isolated from the Antarctic lichen Pertusaria dactylina (Pertusariaceae). The structures of the new compounds were determined by 1D and 2D NMR and HR-MS experiments, as well as by comparison of their data with the published

    更新日期:2020-02-04
  • A New Norsesquiterpenoid from the Rhizomes of Curcuma longa
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-04
    C. Y. Chen, C. L. Kao, H. C. Yeh, P. L. Song, H. T. Li, W. J. Li

    A new norsesquiterpenoid, 4-(1′,5′-dimethyl-3′-oxo-4′-hexenyl)-2-cyclohexen-1-one (1), was isolated from the rhizomes of Curcuma longa (Zingiberaceae). The structure of the new norsesquiterpenoid was elucidated by chemical and physical evidence.

    更新日期:2020-02-04
  • Investigation of the Total Lipidoma from a Zoantharia palythoa sp.
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-04
    T. V. Sikorskaya

    The total lipidome of a symbiotic Zoantharia Palythoa sp., the first representative of the order Zoanthidea (Anthozoa: Hexacorallia), was studied to develop lipidomics of marine organisms. The structures and contents of 145 molecular neutral and polar lipids were established using LC-MS. Lipidomes of Zoantharia, hydrocorals, and reef-building and soft corals were compared. Fatty-acid distributions

    更新日期:2020-02-04
  • New Flavone Glycosides from Astragalus tanae Endemic to Georgia
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-04
    N. Kavtaradze, M. Alaniya, M. Masullo, A. Cerulli, S. Piacente

    The new flavone glycosides tanoside I and II in addition to three known flavonoids and daucosterol were isolated from the Georgian endemic species Astragalus tanae Sosn. Their structures were elucidated as chrysoeriol-7-O-β-D-glucopyranosyl-4′ -O-α-L-rhamnopyranoside, chrysoeriol-4′ -O-α-Lrhamnopyranoside, kaempferol-3-O-β-D-glucopyranosyl(2→1)-O-α-L-rhamnopyranoside (kaempferol-3-O-β-D-neohesperidoside)

    更新日期:2020-02-04
  • Synthesis and Antitumor Activity of 3-Amino-3,4- Seco -Lupa-4(23),20(29)-Diene Derivatives
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-04
    G. V. Giniyatullina, A. G. Mustafin, O. B. Kazakova

    3-Amino-3,4-seco-lupa-4(23),20(29)-diene and its 3,28-bis (cyanoethyl) and 3-aminopropyl derivatives caused growth inhibition or death of nine human cancer cell lines. Leukemia, melanoma, and non-small-cell lung, colon, CNS, and kidney cancer cell lines were most sensitive to these compounds. Antitumor activity decreased with a tosyl group in the C-28 position or acetates on C-3 and C28.

    更新日期:2020-02-04
  • A New Flavonoid Glycoside with α -Glucosidase Inhibitory Activity from Galium Verum
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-01
    Xiao-Hui Zhang, Jie Shen, Chun-Chao Zhao, Jian-Hua Shao

    A new flavonoid glycoside, apigenin 7-O-(2,4-di-O-acetyl)-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (1), was isolated from the 95% EtOH extract of Galium verum L. by repeated column chromatography. Its structure was identified by spectral analyses and chemical methods. In addition, the rat intestinal α-glucosidase inhibitory activity of compound 1 was evaluated in vitro.

    更新日期:2020-02-03
  • A New Neolignan from Justicia Procumbens
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-01
    Weichen Xiong, Yanfang Yang, Yiyi Xiong, Bo Liu, Zhoutao Xie, Hezhen Wu

    A new neolignan, named (7′S,8′R)-5,3′-dimethoxy-4,4′,9′-trihydroxy-2-8′,9-O-7′-neolignan (1), along with two known compounds, secoisolariciresinol (2) and lariciresinol (3), was isolated from the whole plant of Justicia procumbens L. The structure of 1 was established by spectroscopic methods, and the absolute configuration was determined using circular dichroic (CD) spectra.

    更新日期:2020-02-03
  • Synthesized Derivatives of Aloe-Emodin as Proliferation Inhibitors for Human Breast Adenocarcinoma, Human Nonsmall Cell Lung Carcinoma, and Human Cervix Carcinoma
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-01
    Chao Chen, Tingting Cao, Yong Li, Yuegao Hu, Hongjun Yang, Shufan Yin

    Aloe-emodin, which is isolated from Rheum palmatum L. and Aloe vera, has been proved to possess good antiproliferative activity. A series of Aloe-emodin derivatives were designed and synthesized; in addition, they were evaluated as inhibitors of proliferation of human breast adenocarcinoma (MDA-MB-231), human nonsmall cell lung carcinoma (A549), and human cervix carcinoma (HeLa) cells. The biological

    更新日期:2020-02-03
  • Arylbenzofuran Lignans from the Seeds of Arctium lappa and Their Bioactivity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-01
    Qi-Li Mi, Meng-Jie Liang, Qian Gao, Chun-Man Song, Hai-Tao Huang, Yong Xu, Jin Wang, Liang Deng, Guang-Yu Yang, Ya-Dong Guo, Zhang-Yu Chen, Xue-Mei Li

    Two new (1 and 2) and two known arylbenzofuran lignans (3 and 4) were isolated from the seeds of Arctium lappa. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–4 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compound 3 showed good inhibition with IZD of 13

    更新日期:2020-02-03
  • Two Neoflavones from Aconitum Austroyunnanense and their Therapeutic Activity Against Osteoarthritis of the Knee
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-01
    Ziqing Xu, Shicheng Wu, Guicheng Huang, Hongwei Ding, Baohua Zhu, Yang Guo

    In this study, we isolated two new neoflavones from Aconitum austroyunnanense and examined their therapeutic activity against osteoarthritis of the knee. All the tested compounds displayed good anti-inflammatory activity and significantly therapeutic activity against osteoarthritis of rats using surgically induced rat OA models. Compound 1 has the best therapeutic activity and appears to be a promising

    更新日期:2020-02-03
  • Hydroboration–Oxidation of Terpenoids in Targeted Syntheses of Low-Molecular-Mass Bioregulators
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-02-01
    M. P. Yakovleva, V. A. Vydrina, A. A. Kravchenko, G. Yu. Ishmuratov

    Examples of hydroboration–oxidation of natural mono-, sesqui-, di-, and triterpenoids are reviewed. Diborane, BH3·THF, BH3·Me2S, disiamylborane, thexylborane, dicyclohexylborane, 9-borabicyclo[3,3,1]nonane (9-BBN), and diisopinocampheylborane are used as the hydroboration reagents; H2O2 mixed with KOH, NaOH, and NaOAc, as the oxidants. Most of the examples address mono- and sesquiterpenoids with far

    更新日期:2020-02-03
  • Sargassulfamide A, an Unprecedented Amide Derivative from the Seaweed Sargassum naozhouense
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2020-01-31
    Yan Peng, Leilei Cao, Yonghong Liu, Riming Huang

    Sargassulfamide A (1), a unique amide derivative, was isolated from the seaweed Sargassum naozhouense. The structure of the new isolate was established by extensive analysis of various spectroscopic data and single-crystal X-ray diffraction.

    更新日期:2020-01-31
  • Correction to: Two New Pairs of Epimeric Pyrrolizidine Alkaloids from Liparis nervosa
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2019-11-19
    Lin Chen, Jing Li, Shuai Huang, Xianli Zhou

    There is an error in the association of the authors with their affiliations. The correct author names and affiliations are: Lin Chen,1,2 Jing Li,2 Shuai Huang,1 and Xianli Zhou1*

    更新日期:2019-11-19
  • Two New Xanthones from Comastoma pulmonarium and Their Anti-Tobacco Mosaic Virus Activity
    Chem. Nat. Compd. (IF 0.653) Pub Date : 2019-11-18
    Qiu-Fen Hu, Xiao-Long Wang, Wan-Li Zeng, Jin Wang, Yong Xu, Hai-Tao Huang, Jing Li, Xin Liu, Guang-Yu Yang, Xue-Mei Li, Cheng-Ming Zhang, Gang-Peng Li

    Two new xanthones (1 and 2), together with three known xanthones (3–5), were isolated from the whole plants of Comastoma pulmonarium. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 showed high anti-TMV activity

    更新日期:2019-11-18
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