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Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications Planta Med. (IF 2.687) Pub Date : 2021-01-22 Ekiert, Halina; Świątkowska, Joanna; Klin, Paweł; Rzepiela, Agnieszka; Szopa, Agnieszka
Artemisia annua (annual mugwort) is a species that has long been used in traditional Asian medicine, mainly Chinese and Hindu. The species is widespread and known as a medicinal plant not only in Asia but also in Europe, in both Americas, and Australia. The species has become a subject of particular interest due to the 2015 Nobel Prize awarded for detecting the sesquiterpene lactone artemisinin in
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Peperomin E Induces Apoptosis and Cytoprotective Autophagy in Human Prostate Cancer DU145 Cells In Vitro and In Vivo Planta Med. (IF 2.687) Pub Date : 2021-01-21 Lin, Min; Zhu, Qiannan; Li, Yunzhi; Pan, Jigang
Peperomin E was first isolated from Peperomia dindygulensis, an anticarcinogenic herb, and exhibited anticancer activity in many cancer cell lines. To date, it is unknown whether peperomin E has an effect on human prostate cancer DU145 cells in vitro and in vivo. In this study, we used MTT to assess the proliferation inhibition activity of peperomin E in DU145 cells in vitro and observed the cell morphological
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Optimization and Evaluation of Self-nanoemulsifying Drug Delivery System for Enhanced Bioavailability of Plumbagin Planta Med. (IF 2.687) Pub Date : 2021-01-15 Kamble, Pavan Ram; Shaikh, Karimunnisa Sameer
Plumbagin, a potential bioactive lipophilic molecule, possesses limited solubility and low oral bioavailability. The purpose of the present study was to examine the potential of the self-nanoemulsifying drug delivery system for improving solubility and oral bioavailability of plumbagin. The self-nanoemulsifying drug delivery system was formulated from Capmul MCM (oil), Tween 20 (surfactant), and propylene
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Simultaneous Quantification of Ursolic and Oleanolic Acids in Glechoma hederacea and Glechoma hirsuta by UPLC/MS/MS Planta Med. (IF 2.687) Pub Date : 2021-01-15 Grabowska, Karolina; Żmudzki, Paweł; Wróbel-Biedrawa, Dagmara; Podolak, Irma
The content of ursolic acid and oleanolic acid was determined in different plant parts of two Glechoma species, G. hederacea and G. hirsuta. To achieve optimal extraction conditions of ursolic acid and oleanolic acid from plant material, several methods including maceration, heat reflux, Soxhlet, and ultrasonic extraction, as well as various solvents (methanol, dichloromethane, ethyl acetate), were
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1′-Acetoxychavicol Acetate from Alpinia galanga Represses Proliferation and Invasion, and Induces Apoptosis via HER2-signaling in Endocrine-Resistant Breast Cancer Cells Planta Med. (IF 2.687) Pub Date : 2021-01-14 Pradubyat, Nalinee; Giannoudis, Athina; Elmetwali, Taha; Mahalapbutr, Panupong; Palmieri, Carlo; Mitrpant, Chalermchai; Ketchart, Wannarasmi
Estrogen receptor-positive breast cancer patients have a good prognosis, but 30% of these patients will experience recurrence due to the development of resistance through various signaling pathways. This study aimed to evaluate the mode of anticancer effects of 1′-acetoxychavicol acetate, which is isolated from the rhizomes of Alpinia galanga in estrogen receptor positive (MCF7) human epidermal growth
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HPLC-UV, Metabarcoding and Genome Skims of Botanical Dietary Supplements: A Case Study in Echinacea Planta Med. (IF 2.687) Pub Date : 2021-01-14 Handy, Sara M.; Pawar, Rahul S.; Ottesen, Andrea R.; Ramachandran, Padmini; Sagi, Satyanarayanaraju; Zhang, Ning; Hsu, Erica; Erickson, David L.
The use of DNA-based methods to authenticate botanical dietary supplements has been vigorously debated for a variety of reasons. More comparisons of DNA-based and chemical methods are needed, and concordant evaluation of orthogonal approaches on the same products will provide data to better understand the strengths and weaknesses of both approaches. The overall application of DNA-based methods is already
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Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies Planta Med. (IF 2.687) Pub Date : 2021-01-12 Moragrega, Inés; Ríos, José Luis
Medicinal plants and their extracts are natural remedies with enormous potential for treating various diseases, including depression and anxiety. In the case of depression, hundreds of plants have traditionally been used in folk medicine for generations. Different plant extracts and natural products have been analyzed as potential antidepressant agents with validated models to test for antidepressant-like
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Novel Piperidine and 3,4-dihydro-2H-pyrrole Alkaloids from Tilia platyphyllos and Tilia cordata Flowers Planta Med. (IF 2.687) Pub Date : 2021-01-12 Symma, Nico; Bütergerds, Marek; Sendker, Jandirk; Petereit, Frank; Hake, Alexander; Düfer, Martina; Hensel, Andreas
Lime flowers, traditionally used for medical purposes for the treatment of symptoms of the common cold and mental stress, consist of the dried inflorescences including the floral bracts of Tilia cordata, Tilia platyphyllos, Tilia × vulgaris, or mixtures thereof. During phytochemical investigations, 6 different alkaloids – not described until now – were detected in T. cordata and T. platyphyllos flowers
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Formulation of a Semisolid Emulsion Containing Leptospermum scoparium Essential Oil and Evaluation of In Vitro Antimicrobial and Antibiofilm Efficacy Planta Med. (IF 2.687) Pub Date : 2021-01-12 Porter, Gemma C.; Safii, Syarida H.; Medlicott, Natalie J.; Duncan, Warwick J.; Tompkins, Geoffrey R.; Coates, Dawn E.
Manuka oil, an essential oil derived from the Leptospermum scoparium, has been traditionally used for wound care and as a topical antibacterial, antifungal, and anti-inflammatory. However, the essential oil is not well retained at mucosal sites, such as the oral cavity, where the benefits of the aforementioned properties could be utilized toward the treatment of persistent biofilms. Within this study
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Quantification of Silymarin in Silybi mariani fructus: Challenging the Analytical Performance of Benchtop vs. Handheld NIR Spectrometers on Whole Seeds Planta Med. (IF 2.687) Pub Date : 2021-01-12 Mayr, Sophia; Strasser, Simon; Kirchler, Christian G.; Meischl, Florian; Stuppner, Stefan; Beć, Krzysztof B.; Grabska, Justyna; Sturm, Sonja; Stuppner, Hermann; Popp, Michael A.; Bonn, Günther K.; Huck, Christian W.
The content of the flavonolignan mixture silymarin and its individual components (silichristin, silidianin, silibinin A, silibinin B, isosilibinin A, and isosilibinin B) in whole and milled milk thistle seeds (Silybi mariani fructus) was analyzed with near-infrared spectroscopy. The analytical performance of one benchtop and two handheld near-infrared spectrometers was compared. Reference analysis
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The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control Planta Med. (IF 2.687) Pub Date : 2020-12-21 Valli, Marilia; Atanázio, Letícia Cristina Vieira; Monteiro, Gustavo Claro; Coelho, Roberta Ramos; Demarque, Daniel Pecoraro; Andricopulo, Adriano Defini; Espindola, Laila Salmen; Bolzani, Vanderlan da Silva
Natural products are a valuable source of biologically active compounds and continue to play an important role in modern drug discovery due to their great structural diversity and unique biological properties. Brazilian biodiversity is one of the most extensive in the world and could be an effective source of new chemical entities for drug discovery. Mosquitoes are vectors for the transmission of dengue
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Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia Planta Med. (IF 2.687) Pub Date : 2020-12-21 Song, Hong Chuan; Qin, Dan; Liu, Hai Yang; Dong, Jin Yan; You, Chuan; Wang, Yu Meng
Four new β-resorcylic acid lactones, including penochrochlactone A (2), 4-O-desmethyl-aigialomycin B (4), and penochrochlactones C and D (5 and 6), two compounds isolated from a natural source for the first time, 5α, 6β-acetonide-aigialomycin B (1) and penochrochlactone B (3), together with six known compounds, aigialomycin F (7), aigialomycins A, B, and D (8–10), zeaenol (11), and oxozeaenol (12)
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Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes Planta Med. (IF 2.687) Pub Date : 2020-12-21 Bueno, Paula Carolina Pires; Salomé Abarca, Luis Francisco; Anhesine, Naira Buzzo; Giffoni, Maíra Silva; Pereira, Fabiola Manhas Verbi; Torres, Roseli Buzaneli; de Sousa, Rayran Walter Ramos; Ferreira, Paulo Michel Pinheiro; Pessoa, Claudia; Cavalheiro, Alberto José
Casearia sylvestris is an outstanding representative of the Casearia genus. This representability comes from its distinctive chemical profile and pharmacological properties. This species is widespread from North to South America, occurring in all Brazilian biomes. Based on their morphology, 2 varieties are recognized: C. sylvestris var. sylvestris and C. sylvestris var. lingua. Despite the existence
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Precursor-directed Biosynthesis in Tabernaemontana catharinensis as a New Avenue for Alzheimerʼs Disease-modifying Agents Planta Med. (IF 2.687) Pub Date : 2020-12-15 Musquiari, Bruno; Crevelin, Eduardo J.; Bertoni, Bianca W.; França, Suzelei de C.; Pereira, Ana Maria S.; Castello, Ana Carolina Devides; Castillo-Ordoñez, Willian O.; Giuliatti, Silvana; Lopes, Adriana A.
Plants produce a high diversity of metabolites that can act as regulators of cholinergic dysfunction. Among plants, the potential of species of the genus Tabernaemontana to treat neurological disorders has been linked to iboga-type alkaloids that are biosynthesized by those species. In this context, precursor-directed biosynthesis approaches were carried out using T. catharinensis plantlets to achieve
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A Review of the Phytochemistry, Traditional Uses and Biological Activities of the Essential Oils of Genus Teucrium Planta Med. (IF 2.687) Pub Date : 2020-12-09 Gagliano Candela, Rossella; Rosselli, Sergio; Bruno, Maurizio; Fontana, Gianfranco
The genus Teucrium is a large and polymorphic genus of the Lamiaceae family distributed in mild climate zones, particularly in the Mediterranean basin and Central Asia. Studies of nonvolatile constituents of Teucrium species showed that they are a rich source of neo-clerodane diterpenoids, considered as chemotaxonomic markers of the genus. In addition to the nonvolatile metabolites, there has been
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Molecular Networking Discloses the Chemical Diversity of Flavonoids and Selaginellins in Selaginella convoluta Planta Med. (IF 2.687) Pub Date : 2020-12-09 Reginaldo, Fernanda Priscila Santos; Bueno, Paula Carolina Pires; Costa, Isabelly Cristina de Matos; de Araújo Roque, Alan; Fett-Neto, Arthur Germano; Cavalheiro, Alberto José; Giordani, Raquel Brandt
Selaginella convoluta is a desiccation tolerant plant native to the Brazilian semiarid region (Caatinga), endowed with an effective drought resistance mechanism. As part of our research efforts to understand the chemical diversity of S. convoluta, dehydrated (harvested in their natural habitat in the dry season) and hydrated (plant acclimated in a laboratory after rehydration) specimens were analyzed
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Biochemometric Analysis of Fatty Acid Amide Hydrolase Inhibition by Echinacea Root Extracts Planta Med. (IF 2.687) Pub Date : 2020-12-09 Liu, Rui; Burkett, Kelly; Rapinski, Michel; Arnason, John T.; Johnson, Franklin; Hintz, Phil; Baker, John; Harris, Cory S.
Recent research demonstrates that Echinacea possesses cannabimimetic activity with potential applications beyond common contemporary uses for relief of cold and flu symptoms. In this study, we investigated the in vitro inhibitory effect of root extracts of Echinacea purpurea and Echinacea angustifolia on fatty acid amide hydrolase, the main enzyme that degrades the endocannabinoid anandamide. The objective
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Rosmarinic Acid–Human Pharmacokinetics and Health Benefits Planta Med. (IF 2.687) Pub Date : 2020-12-07 Hitl, Maja; Kladar, Nebojša; Gavarić, Neda; Božin, Biljana
Rosmarinic acid is a phenolic compound commonly found in the Lamiaceae (Labiateae) plant species. It is considered responsible for a wide spectrum of biological and pharmacological activities of plants containing this compound. The aim of the current review is to present the fate of rosmarinic acid inside the human body, explained through pharmacokinetic steps and to briefly present the health benefits
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Cardioprotective Function of Green Rooibos (Aspalathus linearis) Extract Supplementation in Ex Vivo Ischemic Prediabetic Rat Hearts Planta Med. (IF 2.687) Pub Date : 2020-12-07 Smit, Sybrand Engelbrecht; Manirafasha, Claudine; Marais, Erna; Johnson, Rabia; Huisamen, Barbara
Diabetic patients develop ischemic heart disease and strokes more readily. Following an ischemic event, restoration of blood flow increases oxidative stress resulting in myocardial damage, termed ischemia/reperfusion injury. Aspalathus linearis (rooibos), rich in the antioxidant phenolic compound aspalathin, has been implicated as cardioprotective against ischemia/reperfusion injury with undefined
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Inhibition of Proinflammatory Cytokine Release by Flavones and Flavanones from the Leaves of Dracaena steudneri Engl. Planta Med. (IF 2.687) Pub Date : 2020-12-07 Nchiozem-Ngnitedem, Vaderament-A; Omosa, Leonidah Kerubo; Bedane, Kibrom Gebreheiwot; Derese, Solomon; Spiteller, Michael
The leaves of Dracaena steudneri yielded 6 new flavonoids–3,5,7-trihydroxy-6-methyl-3′,4′-methylenedioxyflavone (1), 5,7-dihydroxy-3-methoxy-6-methyl-3′,4′-methylenedioxyflavone (2), 3,5,7-trihydroxy-6-methoxy-3′,4′-methylenedioxyflavone (3), (2S,3S)-3,7-dihydroxy-6-methoxy-3′,4′-methylenedioxyflavanone (4), 4′,5,7-trihydroxy-3,3′,8-trimethoxy-6-methylflavone (5), (2R) 7-hydroxy-2′,8-dimethoxyflavanone
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Antiprotozoal activities of Triterpenic Acids and Ester Derivatives Isolated from the Leaves of Vitellaria paradoxa Planta Med. (IF 2.687) Pub Date : 2020-12-07 Catteau, Lucy; Schioppa, Laura; Beaufay, Claire; Girardi, Cynthia; Hérent, Marie-France; Frédérich, Michel; Quetin-Leclercq, Joëlle
Leaves of Vitellaria paradoxa, also called “Shea butter tree”, are used in traditional medicine to treat various symptoms including malaria fever, dysentery, or skin infections. Composition of the dichloromethane extract of V. paradoxa leaves possessing antiparasitic activities was investigated. Five pentacyclic triterpenic acids together with 6 ester derivatives were isolated and identified by standards
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Time-Scale Shifting of Volatile Semiochemical Levels in Wild Type Lychnophora ericoides (Brazilian arnica) and Pollinator Records Planta Med. (IF 2.687) Pub Date : 2020-12-04 Pavarini, Daniel Petinatti; Semir, João; Lopes, João Luís Callegari; da Silva, Ricardo Roberto; Lopes, Norberto Peporine
Lychnophora ericoides is a Brazilian folk phytomedicine from Cerradoʼs “campus rupestris”. Its volatile organic compounds includes bisabolene-derivatives as major compounds. Herein we provide the chemical profiling of constitutive volatile sesquiterpenes from L. ericoides leaves, timeframe emissions surveys, and pollinators records. In situ samples of L. ericoides were harvested. A headspace-solid
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Bioactive Isocedrenes from Perezia multiflora Planta Med. (IF 2.687) Pub Date : 2020-11-23 Bourgeade-Delmas, Sandra; André-Barrès, Christiane; Lucas, Jeanne; Trinel, Manon; Castillo Pareja, Denis; Jullian, Valérie
Four isocedrenes (1 – 4), including one new compound (2), were isolated from an ethanolic extract of the aerial parts of Perezia multiflora by bioactivity-guided fractionation. For compounds 1 and 3, a revised stereochemical assignment is proposed based on molecular modeling studies using DFT-NMR calculations. Antiparasitic activity of the four compounds was evaluated using an in vitro culture of Plasmodium
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Erianthridin Induces Non-small Cell Lung Cancer Cell Apoptosis through the Suppression of Extracellular Signal-regulated Kinase Activity Planta Med. (IF 2.687) Pub Date : 2020-11-19 Boonjing, Sirima; Pothongsrisit, Sutthaorn; Wattanathamsan, Onsurang; Sritularak, Boonchoo; Pongrakhananon, Varisa
Due to the high mortality of lung cancer, natural derivative compounds have been promoted as versatile sources for anticancer drug discovery. Erianthridin, a phenanthrene compound isolated from Dendrobium formosum, exhibits intriguing apoptosis-inducing effects in non-small cell lung cancer cells. Apoptotic nuclei staining assays showed that apoptotic cells with DNA fragmentation and apoptotic bodies
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Nanoencapsulation of Plant Volatile Organic Compounds to Improve Their Biological Activities Planta Med. (IF 2.687) Pub Date : 2020-11-11 Mun, Hakmin; Townley, Helen E.
Plant volatile organic compounds (volatiles) are secondary plant metabolites that play crucial roles in the reproduction, defence, and interactions with other vegetation. They have been shown to exhibit a broad range of biological properties and have been investigated for antimicrobial and anticancer activities. In addition, they are thought be more environmentally friendly than many other synthetic
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Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System Planta Med. (IF 2.687) Pub Date : 2020-11-11 Jaisamut, Patcharawalai; Wanna, Subhaphorn; Limsuwan, Surasak; Chusri, Sasitorn; Wiwattanawongsa, Kamonthip; Wiwattanapatapee, Ruedeekorn
Both quercetin and resveratrol are promising plant-derived compounds with various well-described biological activities; however, they are categorized as having low aqueous solubility and labile natural compounds. The purpose of the present study was to propose a drug delivery system to enhance the oral bioavailability of combined quercetin and resveratrol. The suitable self-microemulsifying formulation
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Erythroxylum pungens Tropane Alkaloids: GC-MS Analysis and the Bioactive Potential of 3-(2-methylbutyryloxy)tropan-6,7-diol in Zebrafish (Danio rerio) Planta Med. (IF 2.687) Pub Date : 2020-11-11 Gondim Lambert Moreira, Letícia; Leite Ferreira, Maria Elisa; Reginaldo, Fernanda Priscila Santos; Lourenço, Estela Mariana Guimarães; Zuanazzi, José Angelo Silveira; Barbosa, Euzébio Guimarães; Ferreira, Leandro de Santis; Fett-Neto, Arthur Germano; Cavalheiro, Alberto José; Luchiari, Ana Carolina; Giordani, Raquel Brandt
Tropane alkaloids are specialized plant metabolites mostly found in the Erythroxylaceae and Solanaceae families. Although tropane alkaloids have a high degree of structural similarity because of the tropane ring, their pharmacological actions are quite distinct. Brazil is one of the main hotspots of Erythroxylum spp. diversity with 123 species (almost 66% of the species catalogued in tropical America)
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Rapid Screening for EGFR Inhibitor in Rhei Radix et Rhizoma by HTRF Assay Coupled with HPLC Peak Fractionation Planta Med. (IF 2.687) Pub Date : 2020-11-11 Fu, Yu; Xie, Zhishen; Zhao, Peng; Lv, Shuangshuang; Chen, Suiqing
In this paper, an HPLC peak fractionation approach combined with homogeneous time-resolved fluorescence analysis is proposed for screening epidermal growth factor receptor inhibitors from Rhei Radix et Rhizoma. With this approach, the amount of sample used for a single HPLC run is sufficient for performing a multiple assay due to the miniaturization ability of the homogeneous time-resolved fluorescence
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Studies on Bignoniaceae: Newbouldiosides D – F, Minor Phenylethanoid Glycosides from Newbouldia laevis, and New Flavonoids from Markhamia zanzibarica and Spathodea campanulata Planta Med. (IF 2.687) Pub Date : 2020-11-06 Kolodziej, Herbert
Continued examination of the stem bark of Newbouldia laevis afforded three minor phenylethanoid glycosides, designated as newbouldiosides D – F. Their structures were elucidated by spectroscopic methods as β-(3,4-dihydroxyphenyl)ethyl 5-O-syringoyl-β-D-apiofuranosyloxy-(1 → 2)-O-[α-L-rhamnopyranosyl-(1 → 3)]-6-O-E-sinapoyl-β-D-glucopyranoside, β-(3,4-dihydroxyphenyl)ethyl β-D-apiofuranosyloxy-(1 →
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Anticancer Potential of Compounds from the Brazilian Blue Amazon Planta Med. (IF 2.687) Pub Date : 2020-11-03 Wilke, Diego V.; Jimenez, Paula C.; Branco, Paola C.; Rezende-Teixeira, Paula; Trindade-Silva, Amaro E.; Bauermeister, Anelize; Lopes, Norberto Peporine; Costa-Lotufo, Leticia V.
“Blue Amazon” is used to designate the Brazilian Economic Exclusive Zone, which covers an area comparable in size to that of its green counterpart. Indeed, Brazil flaunts a coastline spanning 8000 km through tropical and temperate regions and hosting part of the organisms accredited for the countryʼs megadiversity status. Still, biodiversity may be expressed at different scales of organization; besides
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Brown-Algae Polysaccharides as Active Constituents against Nonalcoholic Fatty Liver Disease Planta Med. (IF 2.687) Pub Date : 2020-11-03 Rashed, Zeinab El; Grasselli, Elena; Khalifeh, Hala; Canesi, Laura; Demori, Ilaria
Nonalcoholic fatty liver disease is a metabolic disorder characterized by lipid overloading in hepatocytes that can progress pathogenically and even end in hepatocellular carcinoma. Nonalcoholic fatty liver disease pharmacological treatment is still limited by unwanted side effects, whereas the use of food components with therapeutic potential is advisable. The culinary use of marine algae is traditional
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Physicochemical Stability of Enriched Phenolic Fractions of Cyclopia genistoides and ex vivo Bi-directional Permeability of Major Xanthones and Benzophenones Planta Med. (IF 2.687) Pub Date : 2020-11-03 Miller, Neil; Malherbe, Christiaan Johannes; Gerber, Werner; Hamman, Josias H.; van, Marietader Rijst; Aucamp, Marique; Joubert, Elizabeth
Fractions of an ultrafiltered Cyclopia genistoides extract, respectively enriched in xanthones and benzophenones, were previously shown to inhibit mammalian α-glucosidase in vitro. The present study investigated ex vivo intestinal transport of these fractions, using excised porcine jejunal tissue, to determine whether the gut could be a predominant in vivo site of action. The major bioactive compounds
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Antiproliferative Effects of Pterodon pubescens Extract and Isolated Diterpenes in HaCaT Cells Planta Med. (IF 2.687) Pub Date : 2020-11-03 Basting, Rosanna Tarkany; de Oliveira Sousa, Ilza Maria; Butterweck, Veronika; Foglio, Mary Ann
Pterodon pubescens fruits are popularly used because of their analgesic and anti-inflammatory actions, which are attributed to the isolated compounds with a vouacapan skeleton. This work aimed to evaluate the antiproliferative and anti-inflammatory effects of a P. pubescens fruit dichloromethane extract and the vouacapan diterpene furan isomerʼs mixture (1 : 1) (6α-hydroxy-7β-acetoxy-vouacapan-17β-oate
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Achiote (Bixa orellana) Lipophilic Extract, Bixin, and δ-tocotrienol Effects on Lifespan and Stress Resistance in Caenorhabditis elegans Planta Med. (IF 2.687) Pub Date : 2020-10-29 Gómez-Linton, Darío R.; Alavez, Silvestre; Navarro-Ocaña, Arturo; Román-Guerrero, Angélica; Pinzón-López, Luis; Pérez-Flores, Laura J.
The onset of many degenerative diseases related to aging has been associated with a decrease in the activity of antistress systems, and pharmacological interventions increasing stress resistance could be effective to prevent the development of such diseases. Achiote is a valuable source of carotenoid and tocotrienols, which have antioxidant activity. In this work, we explore the capacity of an achiote
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Profiling and Quantification of the Key Phytochemicals from the Drumstick Tree (Moringa oleifera) and Dietary Supplements by UHPLC-PDA-MS Planta Med. (IF 2.687) Pub Date : 2020-10-21 Fantoukh, Omer I.; Wang, Yan-Hong; Parveen, Abidah; Hawwal, Mohammed F.; Al-Hamoud, Gadah A.; Ali, Zulfiqar; Chittiboyina, Amar G.; Khan, Ikhlas A.
Moringa oleifera is known as a drumstick tree and is cultivated in the subtropics and tropics. It exhibits antihypertensive and antidiabetic effects. An ultra-high-performance liquid chromatography method was developed for the determination of 9 phytochemicals in M. oleifera leaves and marketed products. The efficient separation was achieved within 7 min with a temperature of 45 °C by using a C-18
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Antibacterial Compounds from Mushrooms: A Lead to Fight ESKAPEE Pathogenic Bacteria? Planta Med. (IF 2.687) Pub Date : 2020-10-15 Hamers, Violette; Huguet, Clément; Bourjot, Mélanie; Urbain, Aurélie
Infectious diseases are among the greatest threats to global health in the 21st century, and one critical concern is due to antibiotic resistance developed by an increasing number of bacterial strains. New resistance mechanisms are emerging with many infections becoming more and more difficult if not impossible to treat. This growing phenomenon not only is associated with increased mortality but also
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Comparative Pharmacokinetics of Puerarin Alone and in Pueraria mirifica Extract in Female Cynomolgus Monkeys Planta Med. (IF 2.687) Pub Date : 2020-10-15 Namken, Sureerat; Songvut, Phanit; Nuengchamnong, Nitra; Kemthong, Taratorn; Khemawoot, Phisit; Malaivijitnond, Suchinda
Pueraria mirifica is an endemic Thai plant that has been used for rejuvenation and in the relief of various aging diseases. Puerarin is one of the major isoflavones found in this plant and shows several pharmacological activities in relation to the Thai traditional use of P. mirifica. Therefore, comparative pharmacokinetics of pure puerarin alone and that in a P. mirifica extract in cynomolgus monkeys
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In vitro Antileishmanial, Antitrypanosomal, and Anti-inflammatory-like Activity of Terminalia mollis Root Bark Planta Med. (IF 2.687) Pub Date : 2020-10-15 Muganga, Raymond; Bero, Joanne; Quetin-Leclercq, Joëlle; Angenot, Luc; Tits, Monique; Mouithys-Mickalad, Ange; Franck, Thierry; Frédérich, Michel
This study aims at determining the in vitro antitrypanosomal, antileishmanial, antioxidant, and anti-inflammatory-like activities of Terminalia mollis root crude extracts. The antitrypanosomal and antileishmanial activities on Trypanosoma brucei brucei (strain 427) and promastigotes of Leishmania mexicana mexicana (MHOM/BZ/84/BEL46) were evaluated in vitro. The methanolic root bark extract and standards
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Screening of Bufadienolides from Toad Venom Identifies Gammabufotalin as a Potential Anti-inflammatory Agent Planta Med. (IF 2.687) Pub Date : 2020-10-13 Zheng, Yuanru; Deng, Lijuan; Cao, Huihui; Xu, Nishan; Zhang, Dongmei; Tian, Haiyan; Li, Baojing; Lu, Zibin; Ye, Wencai; Yu, Linzhong; Fan, Chunlin; Liu, Junshan
Toad venom (Chansu) is used in the treatment of infectious and inflammatory diseases in China and East/Southeast Asian countries. However, the anti-inflammatory components of toad venom have not yet been systematically evaluated and clearly defined. To investigate the anti-inflammatory effects of toad venom and identify new anti-inflammatory ingredients, we used zebrafish, an alternative drug screening
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Identification of TRPV1 Ion Channels Agonists of Tropaeolum tuberosum in Human Skin Keratinocytes Planta Med. (IF 2.687) Pub Date : 2020-10-02 Ticona, Luis Apaza; Sánchez, Ángel Rumbero; Estrada, Cristina Thiebaut; Palomino, Olga M.
Tropaeolum tuberosum, commonly known as Mashua, is an herbal remedy used in traditional Andean medicine for the relief of kidney and bladder pain, as well as contusions. This study aimed to evaluate the fractions and isolated compounds from T. tuberosum with analgesic activity mediated by the transient receptor potential vanilloid-1 receptor. A bioguided phytochemical analysis based on NMR/MS was performed
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Simulated Gastrointestinal Biotransformation of Chlorogenic Acid, Flavonoids, Flavonolignans and Triterpenoid Saponins in Cecropia obtusifolia Leaf Extract Planta Med. (IF 2.687) Pub Date : 2020-10-02 Rivera-Mondragón, Andrés; Peeters, Laura; Van, Anastasiader Auwera; Breynaert, Annelies; Caballero-George, Catherina; Pieters, Luc; Hermans, Nina; Foubert, Kenn
It is well known that biotransformation processes in the human body are crucial to form potentially bioactive metabolites from particular classes of natural products. However, little research has been conducted concerning the bioavailability of polyphenols, especially in the colon. The gastrointestinal stability and colonic biotransformation of the crude extract of the leaves of Cecropia obtusifolia
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Effects of a Multicomponent Herbal Extract on the Course of Subclinical Ketosis in Dairy Cows – a Blinded Placebo-controlled Field-study Planta Med. (IF 2.687) Pub Date : 2020-10-01 Durrer, Manuela; Mevissen, Meike; Holinger, Mirjam; Hamburger, Matthias; Graf-Schiller, Sandra; Mayer, Philipp; Potterat, Olivier; Bruckmaier, Rupert; Walkenhorst, Michael
A blinded placebo-controlled multi-center on-farm trial was conducted in dairy cows with subclinical ketosis to investigate effects of a multicomponent herbal extract. Blood ketone levels were measured weekly in early lactating cows from 16 Swiss herds. Cows were subclassified based on their initial blood-β-hydroxybutyrate levels (≥ 1.0 [KET-low, 84 cows] and > 1.2 mmol/L [KET-high, 39 cows]) and randomly
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Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects. Planta Med. (IF 2.687) Pub Date : 2020-09-21 Priscila de Souza,Luísa Nathália Bolda Mariano,Camile Cecconi Cechinel-Zanchett,Valdir Cechinel-Filho
Medicinal plants are used in traditional medicine to treat a wide range of ailments. The knowledge of them is handed down from generation to generation and is described in several pharmacopoeia and in the general literature. The immense biodiversity of the Brazilian flora, covering about 25% of all plant species worldwide, makes Brazil a huge potential source of medicinal plants. Indeed, many of these
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A New Diterpene and Anti-inflammatory Sesquiterpene Lactones from Sigesbeckia orientalis. Planta Med. (IF 2.687) Pub Date : 2020-09-21 Nora S Engels,Barbara Gierlikowska,Birgit Waltenberger,Fang-Rong Chang,Anna K Kiss,Hermann Stuppner
Sigesbeckia orientalis, more commonly referred to as Herba Sigesbeckiae or Xi Xian Cao in traditional Chinese medicine and hy thiêm in traditional Vietnamese medicine, is used in China and Vietnam to treat inflammatory diseases such as arthritis, rheumatism, and joint pain. In initial investigations, the dichloromethane extract from the aerial parts of S. orientalis showed distinct inhibitory effects
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Verbena officinalis (Common Vervain) - A Review on the Investigations of This Medicinally Important Plant Species. Planta Med. (IF 2.687) Pub Date : 2020-09-16 Paweł Kubica,Agnieszka Szopa,Jakub Dominiak,Maria Luczkiewicz,Halina Ekiert
Verbena officinalis (common vervain) is a medicinal plant species widely distributed in the world and commonly used in folk medicine of different countries, including traditional Chinese medicine. Monographs on “Verbenae herba” have been included in the European Pharmacopoeia since 2008, and in the Chinese Pharmacopoeia since 1995. This work presents botanical characteristics of this species. It reviews
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In vitro and In Vivo Immunomodulatory Activity of Physalis angulata Concentrated Ethanolic Extract. Planta Med. (IF 2.687) Pub Date : 2020-09-16 Sérgio Ricardo Teixeira Daltro,Ivanilson Pimenta Santos,Paula Ladeia Barros,Diogo Rodrigo Magalhães Moreira,Therezinha Coelho Barbosa Tomassini,Ivone Maria Ribeiro,Ricardo Ribeiro Dos Santos,Cássio Santana Meira,Milena Botelho Pereira Soares
The need for new immunomodulatory drugs is due to the side effects associated with the prolonged use of the currently used immunomodulatory drugs. In this context, the present work aimed to investigate the immunomodulatory effect of an ethanolic concentrated extract from Physalis angulata. The cytotoxicity of samples was determined using peritoneal macrophages though the Alamar Blue assay. The immunomodulatory
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Punica granatum Leaf Ethanolic Extract and Ellagic Acid as Inhibitors of Zika Virus Infection. Planta Med. (IF 2.687) Pub Date : 2020-09-16 Stefano Acquadro,Andrea Civra,Cecilia Cagliero,Arianna Marengo,Massimo Rittà,Rachele Francese,Cinzia Sanna,Cinzia Bertea,Barbara Sgorbini,David Lembo,Manuela Donalisio,Patrizia Rubiolo
Zika virus, an arthropod-borne flavivirus, is an emerging healthcare threat worldwide. Zika virus is responsible for severe neurological effects, such as paralytic Guillain-Barrè syndrome, in adults, and also congenital malformations, especially microcephaly. No specific antiviral drugs and vaccines are currently available, and treatments are palliative, but medicinal plants show great potential as
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Phytochemical Analysis, In Vitro Anti-Inflammatory and Antimicrobial Activity of Piliostigma thonningii Leaf Extracts from Benin. Planta Med. (IF 2.687) Pub Date : 2020-09-08 Peter Marquardt,Cica Vissiennon,Andreas Schubert,Claudia Birkemeyer,Virgile Ahyi,Karin Fester
The leaves of Piliostigma thonningii are used in traditional medicine in Benin to treat inflammatory skin diseases and infections. So far, pharmacological studies of the anti-inflammatory and anti-infective effects of phytochemically characterized extracts of P. thonningii have been very limited. Therefore, we investigated the in vitro anti-inflammatory and antimicrobial effect of P. thonningii leaf
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Chemical Ecology in Insect-microbe Interactions in the Neotropics. Planta Med. (IF 2.687) Pub Date : 2020-08-27 Carla Menegatti,Taise T H Fukuda,Mônica T Pupo
Small molecules frequently mediate symbiotic interactions between microorganisms and their hosts. Brazil harbors the highest diversity of insects in the world; however, just recently, efforts have been directed to deciphering the chemical signals involved in the symbioses of microorganisms and social insects. The current scenario of natural products research guided by chemical ecology is discussed
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Ameliorating Effects of Dorema ammoniacum on PTZ-Induced Seizures and Epileptiform Brain Activity in Rats. Planta Med. (IF 2.687) Pub Date : 2020-08-26 Marzieh Abizadeh,Soomaayeh Heysieattalab,Negin Saeedi,Narges Hosseinmardi,Mahyar Janahmadi,Farhad Salari,Seyed Mehdi Golpayegani,Asie Shojaii
The objective of the current study was to investigate the anti-epileptogenic and anticonvulsant effects of Dorema ammoniacum gum, which is used in Iranian traditional medicine for the treatment of seizures. Animals received pentylenetetrazol (IP, 30 mg/kg/48 h) for inducing seizures. Five different seizure stages were evaluated for 20 min and parameters including maximum seizure stage, the latency
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Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum. Planta Med. (IF 2.687) Pub Date : 2020-08-20 Asshaima Paramita Devi,Thuc-Huy Duong,Solenn Ferron,Mehdi A Beniddir,Minh-Hiep Dinh,Van-Kieu Nguyen,Nguyen-Kim-Tuyen Pham,Dinh-Hung Mac,Joël Boustie,Warinthorn Chavasiri,Pierre Le Pogam
Three new depsidones, parmosidones F – G (1 – 2), and 8′-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A – C (4 – 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics
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Extract of the Aerial Part of Polygala tenuifolia Attenuates d-Galactose/NaNO2-induced Learning and Memory Impairment in Mice. Planta Med. (IF 2.687) Pub Date : 2020-08-14 Dian Zhang,Xiao Wang,Rong Li,Lin Wang,Zihao Zhou,Qi Fu,Yanjun Cao,Minfeng Fang
Alzheimerʼs disease, one of the most common types of age-related dementia, is characterized by memory deterioration and behavior disorder. The aboveground part of Polygala tenuifolia is a traditional Chinese medicine used for the treatment of amnesia. This study was conducted to investigate the ameliorating effect of the aerial part of P. tenuifolia on d-galactose/NaNO2-induced learning and memory
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Rosmarinic Acid Intravitreal Implants: A New Therapeutic Approach for Ocular Neovascularization. Planta Med. (IF 2.687) Pub Date : 2020-08-14 Lorena Carla Vieira,Carolina Paula de Souza Moreira,Brenda Fernanda Moreira Castro,Oliver Araújo Lacerda Cotta,Luciana Maria Silva,Gustavo de Oliveira Fulgêncio,Armando Silva-Cunha,Sílvia L Fialho
Rosmarinic acid, a plant-derived compound with antiangiogenic activity, can be applied for the treatment of ocular diseases related to neovascularization, such as diabetic retinopathy, macular edema, and age-related macular degeneration. These diseases represent the leading causes of blindness worldwide if they are not properly treated. Intravitreal devices allow for localized drug delivery to the
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Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways. Planta Med. (IF 2.687) Pub Date : 2020-08-11 Qi Zeng,Yun Zeng,Xu Nie,Yingying Guo,Yonghua Zhan
Britanin, a natural pseudoguaiacane sesquiterpene lactone, has significant antioxidant and anti-inflammatory activity, but little is known about its tumor inhibitory activity and the underlying mechanism. Here, we demonstrated in vitro and in vivo that britanin inhibited the growth of human prostate cancer cell lines (PC-3, PC-3-LUC, and DU-145). Through in vitro study, the results showed that britanin
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High-performance Countercurrent Chromatography to Access Rhodiola rosea Influenza Virus Inhibiting Constituents. Planta Med. (IF 2.687) Pub Date : 2020-08-11 Julia Langeder,Ulrike Grienke,Kristin Döring,Mahtab Jafari,Christina Ehrhardt,Michaela Schmidtke,Judith M Rollinger
In a cytopathic effect inhibition assay, a standardized Rhodiola rosea root and rhizome extract, also known as roseroot extract (SHR-5), exerted distinct anti-influenza A virus activity against HK/68 (H3N2) (IC50 of 2.8 µg/mL) without being cytotoxic. For fast and efficient isolation and identification of the extractʼs bioactive constituents, a high-performance countercurrent chromatographic separation
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Antiviral Medicinal Plants of Veterinary Importance: A Literature Review. Planta Med. (IF 2.687) Pub Date : 2020-08-10 Karin Zitterl-Eglseer,Tatiana Marschik
Viruses have a high mutation rate, and, thus, there is a continual emergence of new antiviral-resistant strains. Therefore, it becomes imperative to explore and develop new antiviral compounds continually. The search for pharmacological substances of plant origin that are effective against animal viruses, which have a high mortality rate or cause large economic losses, has garnered interest in the
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Comparative Transcriptome Analysis Reveals Candidate Genes Involved in Isoquinoline Alkaloid Biosynthesis in Stephania tetrandra. Planta Med. (IF 2.687) Pub Date : 2020-08-05 Yangyang Zhang,Yun Kang,Hui Xie,Yaqin Wang,Yaoting Li,Jianming Huang
The roots of Stephania tetrandra are used as a traditional Chinese medicine. Isoquinoline alkaloids are considered to be the most important and effective components in this herb, but little is known about the molecular mechanism underlying their biosynthesis. In this context, this study aimed to reveal candidate genes related to isoquinoline alkaloid biosynthesis in S. tetrandra. Determination of tetrandrine
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Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp. CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways. Planta Med. (IF 2.687) Pub Date : 2020-08-05 Jean-Bosco Jouda,Emmanuel Mfotie Njoya,Serge Alain Tanemossu Fobofou,Zong Yuan Zhou,Zhe Qiang,Céline Djama Mbazoa,Wolfgang Brandt,Guo-Lin Zhang,Jean Wandji,Fei Wang
Three previously undescribed natural products, phomopsinin A – C (1 – 3), together with three known compounds, namely, cis-hydroxymellein (4), phomoxanthone A (5) and cytochalasin L-696,474 (6), were isolated from the solid culture of Phomopsis sp. CAM212, an endophytic fungus obtained from Garcinia xanthochymus. Their structures were determined on the basis of spectroscopic data, including IR, NMR
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Diterpenoids from Leaves of Cultivated Plectranthus ornatus. Planta Med. (IF 2.687) Pub Date : 2020-08-03 Lidivânia Silva Freitas Mesquita,Taynara Simão Matos,Fábio do Nascimento Ávila,Alison da Silva Batista,Andréa Felinto Moura,Manoel Odorico de Moraes,Matheus Carlos Matos da Silva,Talles Luann Abrantes Ferreira,Nilberto Robson Falcão Nascimento,Norberto Kássio Vieira Monteiro,Otília Deusdênia Loiola Pessoa
Two new diterpenoid derivatives 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (1) and 6β-acetoxy-3β,7α,12α-trihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (2) along with 11 (3–13) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C
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Codonopsis lanceolata Contributes to Ca2+ Homeostasis by Mediating SOCE and PLC/IP3 Pathways in Vascular Endothelial and Smooth Muscle Cells. Planta Med. (IF 2.687) Pub Date : 2020-07-30 Min Kyung Kim,A Young Han,You Kyoung Shin,Kwang-Won Lee,Geun Hee Seol
Codonopsis lanceolata has been widely used as an anti-inflammatory and anti-lipogenic agent in traditional medicine. Recently, C. lanceolata was reported to prevent hypertension by improving vascular function. This study evaluated the effects of C. lanceolata and its major component lancemaside A on cytosolic calcium concentration in vascular endothelial cells and vascular smooth muscle cells. Cytosolic
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