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Facile Synthesis of 2-Substituted Quinazolines via Ruthenium(II)-Catalyzed Acceptorless Dehydrogenative Coupling Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-15 Shulei Wu, Qianqian Lei, Zaoduan Wu, Huifang Xie, Chen Zhang, Yu Ye, Meiling Yi, Mingsheng Chen, Hao Xu, Zehua Yang
:: This study aims to develop a practical and facile one-pot synthesis of 2- substituted quinazolines. Using a commercially available and structurally simple ruthenium( II) complex as the catalyst to synthesize a series of quinazoline derivatives via acceptorless dehydrogenative coupling. The mechanism of this reaction was explored by control reaction and DFT calculation. This protocol offers access
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Investigation of the Role of Zirconia and Zirconia-containing Systems as Catalysts in Organic Transformations Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-14 Kobra Nikoofar, Negin Shaddel, Fatemehsadat Jozi
: This review article discusses the applications of zirconia as a catalyst to promote various organic reactions and transformations. The article is subdivided into four main parts: 1) introduction, which consists of the history and introduction of zirconia, elaboration of its synthetic procedures, its application in various fields of science and technology with specified examples, and previously published
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Recent Advances in Hypervalent Iodine Reagents and m-CPBA Mediated Oxidative Transformations Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-14 Ravi Varala, Vittal Seema, Mohammed Amanullah, S. Ramanaiah, Mohammed Mujahid Allam
: Among the several peroxides available, meta-chloroperbenzoic acid (mCPBA) plays an efficient role of oxidizing reagent and is used for many oxidative transformations, such as oxidation of various functional groups, carbon-carbon, carbon-hetero bond formation, heterocyclic ring formation, heteroarylation, oxidative cross-coupling, lactonization, oxidative dearomatization, α-oxytosylation or α-acetoxylation
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Importance and Green Synthesis of Amines: A Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-14 Ashok Raj Patel, Ishwar Patel, Subhash Banerjee
: Amines are “derivatives of ammonia” and important key intermediates for applications in the industrial, pharmaceutical, electronics, etc. They have been used to synthesize industrially important azo dyes, which are used to color various materials. Moreover, amine functionality is present in several important biological molecules. Biogenic amines are found in living organisms and play essential physiological
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Design, Synthesis, and Antimicrobial Evaluation of Novel Sulfonamide Modified with Azoles Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-14 Pratibha Periwal, Ashwani Kumar, Vikas Verma, Devinder Kumar, Mahavir Parshad, Meenakshi Bhatia, Sourbh Thakur
Background:: Sulfonamide, imidazole, and triazole chemical nuclei possess good antimicrobial potential. Aims:: This study aimed to amalgamate sulfonamide, imidazole, and triazole moieties in a single molecular framework with the intent of improving their antimicrobial activities. Objective:: The objective of this study was the synthesis of conjugates containing sulfonamide and azole moieties along
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Synthesis of Novel Propynyl Monoterpene Analogues and their Conjugates with β-DGlucopyranosides Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-12 Rinat R. Gubaidullin, Yulia A. Perfilova, Lyudmila V. Parfenova
: Camphor and carvone exhibit a broad spectrum of biological activity, which determines the prospect of their use as a platform for functionalization to obtain the analogues as potential drugs. The functionalization of camphor and carvone often involves changes to the skeleton of the molecules or their fragmentation. Therefore, in modern medicinal chemistry, research aimed at the development of effective
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A Focussed Analysis of Β-cyclodextrins for Quinoxaline Derivatives Synthesis Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-12 Hena Khatoon, Emilia Abdul Malek
: Cyclodextrins (CDs), which are a type of cyclic oligosaccharides, are widely used in supramolecular chemistry. For example, they can be used to encapsulate volatile compounds, such as drugs, within their hydrophobic cavity. This encapsulation reduces the volatility of the compounds and helps to retain their desired properties. Due to its extraordinary properties, cyclodextrins have been utilized
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Synthetic Update on Antimicrobial Potential of Novel Pyrazole Derivatives: A Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-12 Sucheta Singh, Sumit Tahlan, Kuldeep singh, Prabhakar Kumar Verma
: Heterocyclic compounds containing nitrogen and their derivatives have been a rich source of medicines. Pyrazole, a five-membered ring structure, offers a variety of functionalities as well as stereo-chemical complexity. Studies conducted over the past 10 years revealed that an increasing amount of research has been performed on different pyrazole derivatives and their physiological and pharmacological
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Overview of Synthesis and Applications of Unnatural Lipophilic α-Amino Acids Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-06 Prateek Bhamboo, Smritilekha Bera, Dhananjoy Mondal
: Naturally and synthetically obtained lipophilic α-amino acids exhibit diverse properties and applications in academia and industry. Unnatural hydrophobic/lipophilic amino acids lacking polarity in their side chains manifest the biologically significant structure of peptides and proteins. The hydrophobic effect of lipophilic amino acids stabilizes the structure of proteins, peptides, and enzymes during
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Enantioselective Zirconium-catalyzed Transformations Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-06 Helene Pellissier
: The cheaper and less-toxic metals of Group 4 compared with common metals used in catalysis are increasingly applied in catalysis, resulting in the development of many novel greener transformations. Zirconium is abundant, non-toxic, and exhibits a remarkably diversified chemical reactivity among these metals. Since the first asymmetric zirconium-catalyzed reaction disclosed by Nugent in 1992, a wide
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Using Supercritical Diethyl Ether as the Reaction Medium for the Synthesis of 3-Acetyl and 4-Methyl Substituted Coumarins Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-01 Zeynep Özsırkıntı, Abdul Hakim Hakimi, Mehmet Erşatır, Murat Türk, Onur Demirkol, Elife Sultan Giray
aims: Using supercrticial diethylether as a reaction solvent Abstract: Due to very good biological activity and use as fluorescent probes, coumarin synthesis and developing new synthesis methods are still an attractive area for many research groups. In this work, for the first time, a novel, mild, and green method has been developed for coumarin synthesis by using supercritical diethyl ether as a reaction
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Recent Advances in Solvent-free Organic Transformation Via Iron-doped Nanocatalyst Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-27 Dhananjay N. Gaikwad, Suresh T. Gaikwad, Rajesh K. Manjul, Anjali S. Rajbhoj, Dayanand M. Suryavanshi
: This article highlights current developments in iron-doped nanocatalyst-based solvent-free organic reactions. These catalysts have the potential to speed up processes under safe environmental settings and eliminate the need for hazardous organic solvents. Its application in a variety of fields is mostly due to its superparamagnetic nano diameters, which are affordable, easily separable, reusable
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Synthetic Approaches for Pyranoquinolines: A Concise Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-27 Angie D. Arboleda, Leydi M. Moreno, Rodrigo Abonia
: The pyranoquinoline frameworks have a wide distribution in natural products and have displayed a great amplitude of biological activities, attracting the attention of synthetic and medicinal chemists due to their usefulness in agrochemical and pharmaceutical industries. Among the twenty possible isomeric pyranoquinoline frameworks, research reports for only six of them that were found during the
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Synthesis of Unsymmetrical Diaryl Tellurides Under Mechanical Ball Milling in Room Temperature Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-27 Anup Roy, Subir Panja, Pradipta Kumar Basu, Debasish Kundu
: An efficient transition metal catalyst-free protocol for the synthesis of unsymmetrical diaryl tellurides has been developed by the reaction of diaryl tellurides and aryl diazonium tetrafluoroborates under mechanical ball milling in the absence of any solvent and base under room temperature. InBr (Indium Bromide) plays an important role in generating the organotelluride nucleophile via the Te-Te
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Recent Advances in Self-healing Polymer Materials: Routes and Strategies Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-22 Zhonglin Cao, Jinbao Xu
:: The most intriguing area of scientific study and engineering applications is to synthetize materials that can autonomously heal damage similar to biological tissues. Since the concept of self-healing materials was established, several variations of self-healing polymer materials have been developed based on distinct healing techniques. This review outlines the most recent breakthroughs in self-healing
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A Review on Folklore Uses, Phytoconstituents and Pharmacological Activities of the Genus Berberis Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-22 Zulfa Nooreen, Awani Kumar Rai, Poonam Jaisal, Fariha Summayya, Ankita Wal, Nasir A Siddique
: Genus berberis, an evergreen shrub of about 500 plant species found in subtropical and temperate regions but only some of them are investigated and evaluated for their phytochemistry and bioactivity. These plants are spread worldwide and help in the nourishment of humans and animals. Almost all parts of the plant are investigated for pharmacological and phytochemical purposes, including, roots, fruits
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Nano-biocomposites: A Versatile Combination of Nanocomposites and Biopolymers for the Synthesis of Heterocycles via Multicomponent Reactions Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-02 Archana Rajmane, Arjun Kumbhar
: Organic natural materials like chitosan, cellulose, starch, agarose, and alginate possess unique structures that are useful in creating advanced nanostructured materials. These materials are highly sought after in catalysis because of their numerous functional groups and catalytic properties. They can also be combined with inorganic materials to create "nano-Biocomposites" with specialized properties
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Recent Advances in Synthetic Routes for Biologically Active Tetrahydroquinoxalines and Derivatives: A Comprehensive Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-31 Ashis Kumar Sahoo, Aditya Bhattacharyya
Tetrahydroquinoxalines are found in many biologically and pharmacologically active small molecules. In the past two decades, significant progress has been made in the development of novel synthetic routes for the preparation of biologically active tetrahydroquinoxalines and their derivatives. This synthetic review aims to provide a comprehensive overview of the advancements in the field of various
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Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-31 Shivangi Jaiswal, Jaya Dwivedi, Dharma Kishore, Swapnil Sharma
Tetrazole is a most versatile pharmacophore of which more than twenty FDAapproved drugs have been marketed globally for the management of various diseases. In spite of many remarkable and consistent efforts having been made by the chemists towards the development of greener and sustainable strategies for the synthesis of tetrazole derivatives, this approach still needs more attention. The present review
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Anti-inflammatory Activity and Computational Biology Study of Indole/Pyrimidine Hybrids Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-30 Mostafa Sayed, Ahmed M. Sayed, Ahmed A. El-Rashedy, Abdelreheem Abdelfatah Saddik, Azhaar T. Alsaggaf, Adel M. Kamal El-Dean, Reda Hassanien, Mostafa Ahmed
: This research paper embarks on an interdisciplinary exploration encompassing synthetic chemistry, pharmacology, and computational biology. The development of novel anti-inflammatory agents is an imperative endeavor within pharmaceutical research. Pyrimidines and thienopyrimidines are class of heterocyclic compounds that have gained prominence for their diverse pharmacological properties, including
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Innovations in Treating Sporotrichosis: Drug Repurposing and Lead Compound Synthesis Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-29 Alcione S. de Carvalho, Gabriel R.M. de Freitas, Caroline D. Nicoletti, Fernando de C. da Silva, Débora O. Futuro, Vitor F. Ferreira, Patricia G. Ferreira
: Sporotrichosis, recognized by the World Health Organization (WHO) as a neglected tropical disease and classified among significant fungal health concerns, remains both underestimated and underreported. There is a profound impact of sporotrichosis on public health, affecting both humans and domestic animals. The causative agents are fungi within the Sporothrix genus, primarily transmitted through
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Part 2, Studies on the Synthesis of Quinolone Derivatives with their Biological Activity Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-29 Nishtha Saxena, Swapnil Shankhdhar, Anil Kumar, Nivedita Srivastava
Quinolones are among the class of antibiotics that are used most frequently worldwide and are used for treating a variety of bacterial diseases in humans. Recent research has shown that new, improved analogues of quinolones are being used as anticancer, antifungal, antiviral and other antimicrobial agents. In an earlier review (Part 1), we discussed the synthesis and antibacterial activity of quinolones
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Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Some Novel 3,5-disubstituted-1-phenyl-4,5-dihydro-1H-pyrazole Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-26 Fatih Tok, İlayda Rumeysa Bayrak, Elif Karakaraman, İrem Soysal, Cansel Çakır, Kübra Tuna, Serap Yılmaz Özgüven, Yusuf Sıcak, Mehmet Öztürk, Bedia Koçyiğit-Kaymakçıoğlu
In this study, some new pyrazoline derivatives bearing cyano or nitro groups were synthesized. The structures of the compounds were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis data. The ABTS·+, DPPH·, CUPRAC and β-Carotene/linoleic acid assays were carried out to determine the antioxidant activity of the synthesized pyrazolines. Compound P14 showed higher antioxidant activity than the
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Two-step Continuous-flow Synthesis of 1,2-dimethyl-3-methylsulfanylbenzene via Diazotization and Methanethiolation Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-26 Lixia Li, Qi Zhang, Ce Bian, Wei Wei, Wenxuan Sun, Lu Ji, Hande Wang, Chuan Zhou, Ke Wang, Dangsheng Gong, Dongmao Yan
1,2-Dimethyl-3-methylsulfanylbenzene is the key intermediate of topramezone. This work designed a two-step continuous-flow device to synthesize 1,2-dimethyl-3- methylsulfanylbenzene via diazotization and methanethiolation. The results showed that compared with the batch process, the continuous-flow method greatly shortened the residence time to 1 minute, avoided the accumulation of large amounts of
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Organic Synthesis via Renewable Heterogeneous Nanocatalysts Based on Montmorillonite Clay Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-26 Mustafa M.H. Al-Abayechi, Abbas Al-Nayili, Asim A. Balakit, Gamal A. El-Hiti
Synthetic organic molecules are vital for human life, serving as medications, pesticides, dyes, and food additives. Organic synthesis provides routes for the production of these molecules. The traditional methods of organic synthesis require energy, solvents, time, and certain conditions based on the nature of the reactions. To address the issues associated with conventional processes, various environmentally
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Thiophene-based Solar Cell. A Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-24 Maurizio D'Auria, Lucia Emanuele
: In recent years, perovskite solar cells, which use a hybrid inorganic-organic material, have also made remarkable progress and achieved a rapid increase in efficiency. The organic materials used are usually small conductive molecules, polymers or oligomers. The fused thiophenes, polythiophenes and olithiophenes used for this purpose are presented. The condensed thiophene-based small molecule for
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Synthesis and Biological Evaluation of Cholic Acid Tagged Piperazine Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-24 Dima W. Alshawabkeh, Anas J. Rasras, Saqr Abushattal, Mohammad S. Al Zubi, Mohamad M. Shakdofa, Eyad A. Younes, Raed A. Al-Qawasmeh
: Diseases caused by bacteria are a big challenge for scientists worldwide. These bacteria can be resistant through the adaption of new ways to protect themselves against antimicrobial drugs and thus become multidrug resistance. In this work, new derivatives of 1,3,4-oxadiazole- cholic acid were synthesized and fully characterized using different techniques, such as 1H-NMR, 13C-NMR, and HRMS. Their
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Enzyme Cocktails Catalyzed Bioconversion of Lignocellulosic Biomass into Bioethanol Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-24 Tianlun Dai, Jinshu Huang, Hongguo Wu, Hu Li
: Sustainable production of biofuels from lignocellulosic biomass (LBM) is considered one of the promising solutions to solve the current energy crisis caused by over-reliance on fossil fuels. Enzymatic hydrolysis is a crucial step in determining the efficient conversion of biomass cellulose into biofuels as well as high value-added chemicals, and it has the characteristics of efficient reaction, economy
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Recent Progress in the Synthetic Methods of Pyrazoloquinoline Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-23 Rita M. Borik, Mohamed S. Mostafa, Mohamed S. Behalo, Rizk E. khidre
The focus of this review is on the synthetic routes available for different types of pyrazoloquinoline derivatives. There are three types of synthetic methods: i) from pyrazole derivatives; ii) from quinoline derivatives; and iii) miscellaneous methods. The position of the linkage between pyrazole and quinoline rings determines the seven isomers of pyrazoloquinolines. The purpose of this review is
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Nicotinamide Loaded Chitosan Nanocomplex Shows Improved Anticancer Potential: Molecular Docking, Synthesis, Characterization and In vitro Evaluations Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-23 Ahmed M. Metwaly, M. A. Abu-Saied, Ibraheem M.M. Gobaara, Asmaa M. Lotfy, Bshra A. Alsfouk, Eslam B Elkaeed, Ibrahim H. Eissa
: This study aimed to prepare and characterize chitosan nanoparticles encapsulating a nicotinamide derivative (Ni-CS-NP). Additionally, the therapeutic effectiveness, cytotoxicity, selectivity, and immunomod- ulatory properties of Ni-CS-NP were evaluated in human breast and colon cancer cell lines. Chitosan nanoparticles have shown potential as drug delivery carriers due to their biocompatibility and
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Design, Synthesis and Characterization of Deoxycholic Acid-chalcone Conjugates as Antioxidant Agents Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-17 Sejal Patel, Satyendra Mishra
The present article reports the synthesis, characterization, and antioxidant activity of the chalcone-deoxycholic acid conjugates. The structures of the synthesised bile acidchalcone conjugates have been determined using 1H and 13C NMR spectroscopy. According to the results of the DPPH experiment, compounds 5e (3, 4, 5-methoxy; IC50; 15.04 μg /ml) and 5f (4-hydroxy group; IC50; 11.73 μg /ml) had higher
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Harnessing the Pyrazine Moiety for Potent Anti-inflammatory Activity: A Comprehensive Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-12 Kuldeep Singh, Jeetendra Kumar Gupta, Kamal Saha, Sunam Saha, Marianesan Arockia Babu, Shivendra Kumar, Mohit Agrawal
Inflammation is an intricate physiological reaction that has a vital function in the body's protection against detrimental stimuli. Nevertheless, uncontrolled inflammation may result in the development of long-term conditions, such as arthritis, cardiovascular disorders, and even cancer. Scientists are always searching for new medicinal substances that might efficiently regulate the inflammatory response
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Recent Advances in Electrochemical Sulfonylation using Sodium Sulfinates as Sulfonyl Radical Precursors Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-04 Sen Liang, Jia-Xin Gu, Cheng-Chu Zeng
Sodium sulfinates have been widely utilized as sulfonyl radical precursors for preparing a diverse array of value-added sulfur-containing compounds (sulfones, sulfonamides, sulfonates, thiosulfonates, etc.) through S-C, S-N, S-O and S-S bonds formation reactions. Organic electrosynthesis has become an attractive alternative to conventional methods for redox reactions because it utilizes electric current
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Recent Advances in the Synthesis and Applications of Phenylquinoline-4-carboxylic Acid Derivatives: A Comprehensive Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-04 Sunam Saha, Devender Pathak, Kamal Shah
Phenylquinoline-4-carboxylic acid derivatives have garnered significant attention in recent years due to their diverse pharmacological and industrial applications. This comprehensive review summarizes the latest advancements in the synthesis and diverse range of applications of phenylquinoline-4-carboxylic acid derivatives. This review provides a brief overview of the significance of phenylquinoline-4-carboxylic
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Synthesis of Polyalkoxymethylenedioxy-1,4-naphthoquinones from Parsley Seed Metabolite Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-27 Alexander E. Varakutin, Egor A. Muravsky, Victor N. Khrustalev, Alexander V. Samet, Victor V. Semenov
A convenient synthesis of polyalkoxy-1,4-naphthoquinones, good starting materials for analogues of natural quinones, has been developed. Bromonaphthoquinone, more stable than its hydroxylated analogue, turned out to be a convenient and accessible key synthon for the preparation of various polyalkoxylated naphthoquinones. The obtained quinones could be useful starting materials for the preparation of
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Quinolone Tethered 1,2,3-triazole Conjugates: Design, Synthesis, and Computational Docking Studies on New Heterocycles as Potent Antimicrobial Targets Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-23 Avanthi Basireddy, Tejeswara Rao Allaka, Avekananda Reddy Allam, Sudhakar Reddy Baddam, Sravanthi Basireddy, Kishore Pilli VVN
: The synthesis and biological properties of molecules simultaneously comprising various heterocycles, such as fused 2-quinolones and 1,2,3-triazoles, have been evaluated as a part of our ongoing research in medicinal and organic chemistry. We were successful in developing a synthetic procedure for 1,2,3-triazole substituted quinolone derivatives. Infrared, proton, and carbon nuclear magnetic resonance
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Novel Chalcone Derivatives containing Pyridone and Thiazole Moieties: Design, Synthesis, Molecular Docking, Antibacterial, and Antioxidant Activities Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-23 Rita Borik
: A new series of chalcones 4a-i; 6a,b, and 8 was synthesized from the condensation of ketone 2, which was prepared from the reaction of thiourea derivative 1 with 3-chloropentane-2,4-dione in MeOH at reflux temperature, with substituted aromatic/heterocycle aldehydes in EtOH containing NaOH at room temperature. Antimicrobial and antioxidant activities were assessed for the synthesized compounds. The
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Efficient Synthesis and Characterization of 6-substituted-N-p-tolyl-imidazo[1,2- a]pyridine-8-carboxamide: A Promising Scaffold for Drug Development Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-23 Keval Bhatt, Dhara Patel, Mrudangsinh Rathod, Ashish Patel, Drashti Shah
: Imidazo[1,2-a]pyridine is a highly significant fused bicyclic heterocycle widely utilized in medicinal chemistry, and it holds a prominent position as a "drug prejudice" framework because of its extensive applications. Numerous approaches have been documented for the synthesis of imidazo[1,2-a]pyridines, with a particular focus on functionalizing these compounds. In this research, we have presented
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Unlocking Multifunctional Advantages with Nanocomposites Coatings for Solar Cells: A Comprehensive Review Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-23 Ganesh Regmi
: Nanocomposite coatings have garnered considerable attention as a versatile and innovative solution for addressing the challenges faced by solar cell technologies. This review article provides a comprehensive overview of the multifunctional advantages that nanocomposite coatings offer in the realm of solar cell technology. Furthermore, it delves into the myriad benefits that nanocomposite coatings
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New Functionalized Morpholinothiazole Derivatives: Regioselective Synthesis, Computational Studies, Anticancer Activity Evaluation, and Molecular Docking Studies Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-19 Mohammed A. Assiri, Tarik E. Ali, Maha N. Alqahtani, Ibrahim A. Shaaban, Ali. A. Shati, Mohammad Y. Alfaifi, Serag E.I. Elbehairi
A new series of skeletons 2-(morpholinoimino)-4,5-disubstituted-3- phenylthiazoles (2-15) was synthesized. The methodology involved the reactions of 1- morpholino-3-phenyl-thiourea (1) with a variety of α-halocarbonyl compounds under Hantzsch reaction conditions. The reaction mechanism for some postulated routes was modeled using quantum mechanical calculations in order to investigate the regioselectivity
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New Ureas and Amides - An Account of Recent Trends and Developments in Low Molecular Weight Gelators Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-12 Ajaykumar Manibhai Patel, Varsha Bhardwaj, Amar Ballabh
: The last 20 years have witnessed major advancements in the field of supramolecular chemistry and have brought us closer to the designing of low molecular weight gelators with desired properties and applications. In that regard, amide- and urea- based gelators comprise a unique class as they are extremely versatile in terms of molecular design and offer a wide range of applications, like anion responsive
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Influence of Dispersion Interactions in the Diels-Alder Reaction of Cyclopentadiene, Anthracene and Tetracene with C60: A DFT Examination Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-11 Alexey N. Masliy, Andrey M. Kuznetsov
The activation and thermodynamic parameters of the Diels-Alder reaction of cyclopentadiene, anthracene and tetracene with C60 fullerene are estimated at the DFT level using PBE0, B3LYP and CAM-B3LYP functionals and the effect of accounting for dispersion interactions in various semi-empirical Grimme models on these parameters. Structural characteristics of the reagents, products, pre-reaction van der
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Enantioselective Synthesis, Computational Molecular Docking and In Vitro Anticoagulant Activity of Warfarin-based Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-11 Zakia Afzal, Naghmana Rashid, Humaira Nadeem, Arif-ullah Khan, Zaman Ashraf
Warfarin containing a 4-hydroxycoumarin moiety possesses excellent anticoagulant activity, with the (S) enantiomer being the eutomer. The present work is designed to synthesize warfarin based derivatives enantioselectivity to explore their anticoagulant potential. The substituted chalcones were reacted with 4-hydroxycoumarin in the presence of the chiral organocatalyst 9-amino-9-deoxyepiquinine to
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Synthesis and Gas Permeation Properties of Functionalized Norbornene-Based Polymers Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-11 Alejandro Onchi, Carlos Corona-García, Arlette A. Santiago, Mercedes Gabriela Téllez Arias, Ismeli Alfonso, Joel Vargas
: Functionalized polynorbornenes are very important specialty materials for a wide variety of practical and industrial applications. In the membrane technology field, polynorbonene derivatives play a main role in gas transport since they can be systematically and easily functionalized, thus affecting the membrane performance in gas separation processes. Thus, several methodologies have been employed
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Cholapod and Cholaphanes for Recognition of Anions Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-07 Mamta Chahar, Sarita Khaturia, Anjali Bishnoi
Deoxycholic and cholic acid-based receptors 6, 13, and 16 containing imidazolium groups were synthesized, and their properties as anion receptors have been evaluated. Cholaphanes 13 and 16 exhibited moderate binding selectivity and affinity for fluoride ions, while cholapod 6 showed low binding selectivity and affinity for chloride ions due to the presence of a nitro group in the imidazolium ring.
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Boesenbergia rotunda (L.) Mansf.: A Review of Phytochemistry, Pharmacology, and Pharmacokinetics Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-06 Nguyen Quang Hop, Ninh The Son
Boesenbergia rotunda (the family Zingiberaceae) is a well-known medicinal plant from Southeast Asia and China. Its parts, especially the roots, were used as an alternative in cuisine, and flavoring. Many attempts tend to explore its phytochemistry and pharmacological values. The ultimate goal of this review is to critically offer the pharmacological values and mechanisms of action of B. rotunda crude
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Diverse Pharmacological Potential of Various Substituted Pyrimidine Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-06 Abdulaziz Alsharif, Mamdouh Allahyani, Abdulelah Aljuaid, Ahad Amer Alsaiari, Mazen Mohammed Almehmadi, Mohammad Asif
In many significant bioactive heterocyclic compounds, the six-membered ring pyrimidines play a major role as bioactive components. There is a lot of room for innovation in the fields of medicinal chemistry and the chemical industries because of the numerous pyrimidine synthesis methods and their varied reactions. The pharmacological effects of pyrimidine derivatives include anticonvulsant, antibacterial
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An Overview of Chemistry and Bioactivity of Non-diterpenoid Alkaloids in the Genera Aconitum and Delphinium (Ranunculaceae) Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-06 Tianpeng Yin, Hongjun Jiang
Tribe Delphineae in the family Ranunculaceae is composed of the genera Aconitum and Delphinium and is a resource plant group with important medicinal value. Alkaloids are the main active ingredients in these two genera, with previous studies primarily focusing on diterpenoid alkaloids. Recent comprehensive studies of the chemical components have uncovered numerous non-diterpenoid alkaloids of diverse
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Edible Oils and Development of New Products: Sensory, Microbiological, and Cytotoxic Aspects Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-06 Fabiane do Espírito Santo de Jesus, Tayane de Jesus Freitas, Alana Moreira Bispo, Lívia de Matos Santos, Agnes Sophia Braga Alves, Bruna Aparecida Souza Machado, Camila Duarte Ferreira Ribeiro
Edible oils offer several health benefits. Their inclusion in food products can improve the nutritional profile while reducing saturated and trans fats. This research aimed to evaluate the sensory, microbiological, and cytotoxic characteristics of edible oils and analyze how these characteristics behave when oils are added to food products. A comprehensive search of scientific articles was conducted
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Connection Number-based Multiplicative Zagreb Indices of Chemical Structures Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-01 Muhammad Mudassar Hassan
topological index is a quantitative measure of molecular structure and connection. It also estimates the toxicological, structural, biological, and physicochemical characteristics of a chemical molecule. The use of nano-structured graphs in the study of chemistry is very extensive. Melem, one of the most significant tri−s−triazine compounds, is a nucleophilic reagent that may be employed in reactions
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The Recent Report on Schiff Bases and their Complexes as DNA Binders Curr. Org. Chem. (IF 2.6) Pub Date : 2023-11-30 Mansi, Charu Bhutani, Pankaj Khanna, Manisha Jain, Sangeeta Talwar, Shilpa Yadav, Leena Khanna
Schiff bases are dynamic organic compounds of bioactive importance, acting as flexible ligands and can form complexes with metals. Schiff bases along with their metal complexes have shown a large affinity towards DNA, which is one of the main targets of chemotherapeutics. DNA can join hands with these motifs in multiple ways, like covalent (crosslinking adducts) and non-covalent (intercalative or groove
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Synthetic and Biological Studies of Some Pyrrolidine-Tethered Novel Aurones against Digestive Enzymes Curr. Org. Chem. (IF 2.6) Pub Date : 2023-11-28 Sanjeev Kumar, Bhavna Saroha, Ekta Lathwal, Gourav Kumar, Priyanka Arya, Neera Raghav, Ramesh Kumar, Suresh Kumar
Amylase, lipase, and trypsin are crucial digestive enzymes, whose activation or inhibition is of potent therapeutic approach for treating various body disorders. In this work, we have synthesized a small library of pyrrolidine-tethered novel aurones 4(a-k) and structures validated by analyzing their IR, NMR (1H and 13C), and mass spectrometry data. The biological activities of the synthesized aurones
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Various Synthetic Methods and Diverse Therapeutic Potential of Substituted Thiazine Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2023-11-27 Mohammad Asif, Mamdouh Allahyani, Ahad Amer Alsaiari, Mazen Mohammed Almehmadi
Heterocyclic compounds are currently of great interest in pharmaceutical research. Many natural products, including vitamins, hormones, and antibiotics, contain heterocyclic compounds, and these substances have grown in importance. Heterocyclic thiazine derivatives have numerous pharmacological actions, including anticancer, antimicrobial, antipsychotic, anti-mycobacterial, anti-fungal, antiviral,
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Regioselectivity Inversion in Hydroformylation of Aryl Alkenes with a Diphosphoramidite-rhodium Catalyst Curr. Org. Chem. (IF 2.6) Pub Date : 2023-11-21 Carmela G. Arena
Rhodium catalysts for hydroformylation of aryl alkenes generally promote the formation of branched aldehydes. Here, we have demonstrated that by using a single rhodium catalyst containing a diphosphoramidite ligand derived from BINOL, it is possible to achieve the inversion of regioselectivity in the hydroformylation of aryl alkenes simply by reducing the syngas pressure or, alternatively, increasing
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Recent Advances on the Synthesis of Orally Active Antiviral Drug Molnupiravir Curr. Org. Chem. (IF 2.6) Pub Date : 2023-11-21 Tanmoy Sahoo, Basi V. Subba Reddy
Molnupiravir is one of the simple orally active antiviral drugs, sold under the brand name Lagevrio. Initially, this drug was used to treat the influenza virus but later on, used against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This is the first orally active and direct-acting antiviral drug and is highly effective against SARS-CoV- 2. In this review, we discuss different synthetic
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Design, Synthesis, Reactions, Molecular Docking, Antitumor Activities of Novel Naphthopyran, Naphthopyranopyrimidines, and Naphthoyranotriazolopyrimidine Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2023-11-13 Rita Mohammed Ahmed Borik, Nasser Jaber Hadi Ameri, Yousef Essa Mukhrish, Ashraf Hassan Fekry Abd El-Wahab, Hany Mostafa Mohamed, Diaa Abd El-Samie Ibrahim, Ahmed Deeb Hassan Deeb
In ethanolic piperidine solution, the interaction of 6-bromonaphthalen-2-ol (1) with α- cyano-p-chlorocinnamonitrile (2a) or ethyl α-cyano-p-chlorocinnamate (2b) yielded 4Hnaphtho[ 2,1-b]pyran-3-carbonitrile (3a) and 4H-naphtho[2,1-b]pyran-3-carboxylate (3b). The naphthopyran derivatives (3a, b) reacted with electrophilic reagents afforded naphthopyranopyrimidines and naphthopyrano-triazolopyrimidine
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Energy-efficient Approach to Multicomponent Reaction for the Synthesis of Therapeutically Relevant Heterocycles Curr. Org. Chem. (IF 2.6) Pub Date : 2023-11-01 Ritwik Roy, Rahul Kumar, Md. Nurul Ansari, Gauri S. Deshmukh, Animesh Kumar Rai, Garima Tripathi, Abhijeet Kumar
Abstract: Multi-component reactions have been used as an important synthetic strategy for the synthesis of diverse varieties of therapeutically useful heterocyclic scaffolds. High atom economy, one-pot reaction, and involvement of synthetically simple steps are some of the interesting features that make MCRs greener compared to conventional methods. The development of environmentally benign and eco-friendly
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Synthetic Routes and Pharmacological Activities of Purine Derivatives: A Review Curr. Org. Chem. (IF 2.6) Pub Date : 2023-11-01 Soukaina Benkirane, Houria Misbahi, Meriem Boudkhili, Youssef Kandri Rodi, Nada Kheira Sebbar, El Mokhtar Essassi
The Purine moiety is regarded as the ubiquitous nitrogen-containing heterocycle in nature and is recognized as a privileged scaffold in medicinal chemistry. Moreover, the purine derivatives are heterocyclic aromatic compounds consisting of conjoined pyrimidine and imidazole moieties. Purine derivatives are involved in various metabolic processes as cofactors associated with a wide variety of enzymes
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5-Aminolevulinic Acid Tautomers: Theoretical Elucidation of pKa’s, Species Distribution and Dimerization Constants Curr. Org. Chem. (IF 2.6) Pub Date : 2023-10-25 Gabriela Mendoza-Sarmiento, José Antonio Guevara-García, Adriana Pérez-González, Virginia Montiel-Corona
5-aminolevulinic acid (5-ALA) applications in medicine and agriculture face the challenge of stability. In aqueous solutions, concentration, pH, and temperature have an effect on the loss of activity. Computational chemistry helps to determine tautomerization, formation of derivatives and the stability, in different conditions, in a short time and reducing the cost of analysis. This work aimed to model
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Dess-Martin Periodinane (DMP) in Organic Synthesis-A Septennial Update (2015-till date) Curr. Org. Chem. (IF 2.6) Pub Date : 2023-10-25 Ravi Varala, Vittal Seema, Mohammed Mujahid Alam, Mohammed Amanullah, Narsimhaswamy Dubasi
Dess-Martin periodinane (DMP) is one of the hypervalent iodines that is most frequently utilized as an oxidizing agent in organic chemistry. The authors of this septennial review have critically and methodically presented representative applications of DMP in organic synthesis from 2015 to the present, including oxidations, dehydrogenations, hetero and homo-dimerizations, aromatizations, thiocyanations