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Ameliorative Potential of Pumpkin Seed Oil (Cucurbita pepo L.) Against Tramadol-Induced Oxidative Stress Dose-Response (IF 2.5) Pub Date : 2024-01-16 Ezebuilo U. Ekpono, Ejike D. Eze, Afodun M Adam, Udu A. Ibiam, Orji U. Obasi, Josiah E. Ifie, Ejike U. Ekpono, Esther U. Alum, Sana Noreen, Chinaza G. Awuchi, Patrick M. Aja
Background of the StudyThe increase in the therapeutic use of tramadol in the management of moderate to severe pains in some disease conditions and its unregulated access has led to its associated toxicity and there is little or no information on the protection against its associated toxicity.Aim of the StudyConsidering the medicinal value of pumpkin seed oil, its availability, and neglected use, it
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Phytochemical Properties of Crataegus azarolus Berries Decoction Extract and Evaluation of its Protective Activity Against Acetic Acid-Induced Ulcerative Colitis in Rats Dose-Response (IF 2.5) Pub Date : 2024-01-11 Houcem Sammari, Saber Jedidi, Houcine Selmi, Mourad Jridi, Ala Ayari, Hichem Sebai
The present study aims to evaluate the protective effect of Crataegus azarolus berries decoction extract (CAB-DE) against acetic acid-induced ulcerative colitis as well as the mechanisms implicated in such protection. Adult male Wistar rats were separated into seven groups: Control (H2O), acetic acid (AA), AA + various doses of CAB-DE (100, 200, and 400 mg/kg, b.w.,p.o.), and AA + sulfasalazine (100
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Evaluation of Glycogen Synthase Kinase Pathway for Assessing the Antidepressant-like Effect of Glucosamine as a Radioprotector in Rats: Behavioral and Biochemical Studies. Dose-Response (IF 2.5) Pub Date : 2023-11-21 Mai H Mekkawy,Heba M Karam,Marwa A Mohamed,Dina M Lotfy
Radiotherapy is a very important tool in the treatment of cancer; nevertheless, its side effects are a hindrance to its use. The present study is designed to evaluate glucosamine effects against radiation-induced brain oxidative stress and depression-like effect in rats. Four groups of female Wister rats were used as control, irradiated (4 × 2 Gy), glucosamine (1 g/kg P.O), and glucosamine + irradiated
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Insecticidal and Repellent Activities of Four Essential Oils Against Sitophilus zeamais (Coleoptera: Curculionidae). Dose-Response (IF 2.5) Pub Date : 2023-11-20 Hany Ahmed Fouad,Cláudio Augusto Gomes da Câmara,Marcílio Martins de Moraes,Wagner de Souza Tavares,Jesusa Crisostomo Legaspi,José Cola Zanuncio
Objective This study aimed to evaluate the efficacy of Corymbia citriodora, Melaleuca alternifolia (Myrtaceae), Mentha × piperita (Lamiaceae), and Schinus terebinthifolius (Anacardiaceae) essential oils as an alternative to manage Sitophilus zeamais (Coleoptera: Curculionidae) adults. Methods Acute contact toxicity, acute toxicity on treated maize grain, fumigation toxicity, repellency bioassays, and
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Complexing Properties of Synthesized 1,3,5-Triaza-7-Phosphaadamantane Derivatives Towards Some Lanthanides and Transition Metal Cations With Significant Antimicrobial and Antioxidant Activities. Dose-Response (IF 2.5) Pub Date : 2023-11-16 Lassaad Baklouti,Besma Mellah,Waleed S Koko
The synthesis of new water-soluble N-alkylated derivatives of 1,3,5-triaza-7-phosphaadamantane is presented. Ru(PPh3)2Cl2 has been used to react with 1-(4-nitrobenzyl)-3,5-triaza-1-azonia-7-phosphaadamantane bromide (PTAR). By using elemental analysis, NMR, and IR spectroscopy, the obtained compounds were identified. The UV-visible absorption spectroscopy has been used to monitor the complexation of
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Green Lead Nanoparticles Induced Apoptosis and Cytotoxicity in MDA-MB-231 Cells by Inducing Reactive Oxygen Species and Caspase 3/7 Enzymes. Dose-Response (IF 2.5) Pub Date : 2023-11-10 Wadyan Lafi Alsulami,Daoud Ali,Bader O Almutairi,Khadijah N Yaseen,Saad Alkahtani,Rafa A Almeer,Saud Alarifi
Nanoparticles are widely used in the pharmaceutical, agriculture, and food processing industries. In this study, we have synthesized green lead nanoparticles (gPbNPs) by using an extract of Ziziphus spina-christi leaves and determined their cytotoxic and apoptotic effect on the human breast cancer MDA-MB-231 cell line. gPbNPs were characterized by using X-ray diffraction (XRD), energy dispersive X-ray
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Air Pollution and Cardiac Diseases: A Review of Experimental Studies. Dose-Response (IF 2.5) Pub Date : 2023-11-04 Laura C Palacio,Diana C Pachajoa,Carlos A Echeverri-Londoño,Javier Saiz,Catalina Tobón
Air pollution is associated with around 6.5 million premature deaths annually, which are directly related to cardiovascular diseases, and the most dangerous atmospheric pollutants to health are as follows: NO2, SO2, CO, and PM. The mechanisms underlying the observed effects have not yet been clearly defined. This work aims to conduct a narrative review of experimental studies to provide a more comprehensive
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Curcumin's Dose-Dependent Attenuation of Gastric Cancer Cell Progression Via the PI3K Pathway Blockade. Dose-Response (IF 2.5) Pub Date : 2023-11-03 Gen Xi,Qingtao Dong,Bo Yang,Desheng Jiao,Shahanavaj Khan
Background: Gastric cancer stands as a primary cause of cancer-related deaths worldwide, making the discovery of new therapeutic agents essential for enhancing treatment outcomes. Curcumin, a polyphenolic compound found in turmeric (Curcuma longa), has demonstrated potential in multiple cancer types due to its anti-cancer characteristics. This research aimed to examine the impact of curcumin on gastric
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Assessing the Risk of Secondary Cancer Induction in Radiosensitive Organs During Trigeminal Neuralgia Treatment With Gamma Knife Radiosurgery: Impact of Extracranial Dose. Dose-Response (IF 2.5) Pub Date : 2023-10-26 Ghazale Geraily,Ali Ameri,Atefeh Mahmoudi,Mohadese Moafee,Javad Teymouri
Purpose Gamma knife radiosurgery (GKRS) delivers high-dose external radiation to a small intracranial lesion. However, scattering and leaked radiation can deposit a portion of the dose outside the radiation field, which may pose a risk to radiation-sensitive patients, such as pregnant women. Trigeminal Neuralgia (TN) is treated with one of the highest GKRS doses (80-90 Gy). This study aimed to estimate
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In Vitro Antioxidant and Inhibitory Study of Picrorhiza kurroa (Kutki), Syzygium aromaticum (Loung), Lawsonia inermis (Henna), Rheum emodi (Revand Chini), Curcuma longa (Haldi) Against Lipid Per-Oxidation in Mice Brain and Liver. Dose-Response (IF 2.5) Pub Date : 2023-10-25 Farooq Hassan,Asmat Ullah Khan,Syed Zahoor Ul Hassan Zaidi,Madiha Khan Niazi,Muhammad Amjed Ismail
The aerobic organisms not only need oxygen for survival, but oxygen is also fundamentally malignant to the aerobic organism on the grounds of free radical generation and their affiliation with free oxidative stress. This study was done to evaluate the antioxidant and protective properties of P kurroa, S aromaticum, L inermis, R emodi, and C longa against lipid peroxidation induced by different pro-oxidants
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Fabrication, Properties, and Stability of Oregano Essential Oil and Sodium Alginate-Based Wound-Healing Hydrogels. Dose-Response (IF 2.5) Pub Date : 2023-10-09 Dure Najaf Iqbal,Asia Ashraf,Arif Nazir,Samar Z Alshawwa,Munawar Iqbal,Naveed Ahmad
The wound dressings fabricated by polymers and oregano essential oil (OEO) can be very effective as a hydrogel. The current study has been focused on fabricating the hydrogel membranes of oregano oil encapsulated as an antibacterial agent into sodium alginate (SA) solution by solvent casting method and then evaluated the antibacterial, antioxidant activity, and physicochemical performance of SA/OEO-based
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Dose Dependent Effect of Sulfamethoxazole on Inhibiting KATP Channel of Mouse Pancreatic β Cell. Dose-Response (IF 2.5) Pub Date : 2023-09-28 Hiroshi Ogata,Shigeki Kitamura,Makoto Fujiwara,Masaru Shimizu,Chengbo Tan,Songji Zhao,Yuko Maejima,Kenju Shimomura
Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (KATP) channels and induces insulin secretion. However, there are no detail reports that measure the effective dose that can close KATP channels and induce insulin secretion. In this study,
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Toxic Potential of Crude Extract From Cassava Cortex Containing Scopoletin and Cyanide on Wistar Rats and Broilers. Dose-Response (IF 2.5) Pub Date : 2023-09-22 Youchahou Ndam Njankouo,Maximilienne Ascension Nyegue,Ibrahim Njingou,Paul Fewou Moundipa,Pauline Mounjouenpou
The present work aimed to evaluate acute and sub-acute toxicity of cortex cassava crude extract containing scopoletin and cyanide. The limit test method of OECD at 2000 mg/kg was used to determine the LD50 of the crude extract in female Wistar rats, and the sub-acute toxicity was conducted in broilers by incorporating their feed with the cortex powder at 2 mg, 4 mg and 8 mg of powder per 100 g of standard
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Prospective Nutraceutical Effects of Cinnamon Derivatives Against Insulin Resistance in Type II Diabetes Mellitus-Evidence From the Literature. Dose-Response (IF 2.5) Pub Date : 2023-09-10 Saima Naz Mohsin,Faiza Saleem,Ayesha Humayun,Afifa Tanweer,Ambreen Muddassir
Apart from advances in pharmaceutical antidiabetic agents, efforts are being made toward hypoglycemic agents derived from natural sources. Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antidiabetic, and anti-hypertriglyceridemic agent. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and solvent
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Olea europaea L. Leaf Extract Alleviates Fibrosis Progression and Oxidative Stress Induced by Bleomycin on a Murine Model of Lung Fibrosis. Dose-Response (IF 2.5) Pub Date : 2023-09-02 Sana Bahri,Anouar Abidi,Afef Nahdi,Raed Abdennabi,Mona Mlika,Ridha Ben Ali,Saloua Jameleddine
In this study, we aim to investigate the effect of industrial Olea europaea L. leaf extract (OLE) against bleomycin (BLM)-induced pulmonary fibrosis (PF) in rats. Male Wistar rats were treated with a single intratracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of OLE (10, 20, and 40 mg/kg) for 4 weeks. Results of HPLC and LC-MS analysis revealed a large amount of oleuropein
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Valorization of Baker Yeast Industry Waste in Agriculture by Improving Germination and Growth of Barley and Pea. Dose-Response (IF 2.5) Pub Date : 2023-08-30 Nadhem Aissani,Rania Aissani,Makrem Ghidaoui,Ferjeni Zouidi,Hichem Sebai
Industrial waste still present an environmental danger for the nature and survival of all living beings. Among these toxic products, the focus has been on liquid effluents from the baker's yeast industry that cause real environmental problems mainly due to their pollutant load and the release of unpleasant odors. In order to minimize these hazards and to take advantage of these wastes for the sake
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Exposure to Cadmium Telluride Quantum Dots and Gene Expression Profile of Huh-7 Hepatocellular Carcinoma Cell Line. Dose-Response (IF 2.5) Pub Date : 2023-08-24 Hani Alothaid,Mashael R Al-Anazi,Arwa A Al-Qahtani,Dilek Colak,Azeez Yusuf,Mohammed S Aldughaim,Ali M Mahzari,Mahmoud M Habibullah,Saud Alarifi,Saad Alkahtani,Ahmed A Al-Qahtani
Nanoparticles have shown promising potential for efficient drug delivery, circumventing biological interferences like immunological and renal clearance and mechanical and enzymatic destruction. However, a handful of research papers have questioned the biomedical use of metal-based nanoparticles like cadmium telluride quantum dots (CdTe-QDs) for their cytotoxic, genotoxic, and carcinogenic potential
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Scutellarin Inhibits Glioblastoma Growth in a Dose-dependent Manner by Suppressing the p63 Signaling Pathway. Dose-Response (IF 2.5) Pub Date : 2023-08-24 Yongjie Chen,Wenlan Li
Although scutellarin has been extensively investigated, its effects on glioma are unclear. This study intended to reveal this regulation and the underlying mechanisms. The U251, M059K, and SF-295 cell lines were treated with gradient concentrations of scutellarin and then IC50 was calculated. SF-295 cells selected for subsequent procedures were treated with four concentrations of scutellarin. Then
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Pharmacological Activities and In-Silico Studies of Bioactive Compounds Identified in Organic Fractions of the Methanolic Extract of Citrullus Colocynthis. Dose-Response (IF 2.5) Pub Date : 2023-07-05 Haseeb Akram Sindhu,Muhammad Afzal,Izzah Shahid
Medicinal plants have been extensively exploited for their immense pharmacological and immune-supporting potential. Fruit of Citrullus colocynthis has several active secondary metabolites such as phenolics, flavonoids, and essential oils that are used in traditional medicines as antidiabetic, anti-inflammatory, antioxidant, and antimicrobial agents. In this study, phytoconstituents in organic fractions
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Radioactive 125I Seed Inhibits Cell Migration and Invasion and Promotes Apoptosis by Inactivating the VEGFR2 Signaling Pathway in Cholangiocarcinoma. Dose-Response (IF 2.5) Pub Date : 2023-07-01 Jun Luo,Jiaping Zheng,Hongxiang Yao,Binbing Wang,Zhewei Zhang,Guoliang Shao
Objectives To investigate the potential mechanisms of 125I seed implantation therapeutic treatment on inactivating the VEGFR2/PI3K/AKT pathway in cholangiocarcinoma. Methods The human cholangiocarcinoma cell lines HCCC-9810 and HuCCT1 were purchased for in vitro studies. The BALB/c nude mice were obtained for in vivo studies. The proliferation of cells was detected by CCK-8, colony formation, and BrdU
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RETRACTION NOTICE: Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels after Focal Cerebral Ischemia in Rats. Dose-Response (IF 2.5) Pub Date : 2023-06-29
[This retracts the article DOI: 10.1177/1559325819901242.].
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Gene Signatures for Latent Radiation-Induced Lung Injury Post X-ray Exposure in Mouse. Dose-Response (IF 2.5) Pub Date : 2023-06-28 Tongtong Zhang,Zhaoming Zhou,Lei Wen,Changguo Shan,Mingyao Lai,Jing Liao,Xin Zeng,Gang Yan,Linbo Cai,Meijuan Zhou,Minghua Wang
Objective To investigate the X-ray-specific sensitive genes and potential signaling pathways involved in the latent period of radiation-induced lung injury (RILI) in mouse models. Method Mice were randomized into groups for whole thoracic irradiation with a single fraction of 20 Gy X-ray or 12.5 Gy carbon heavy ion. Lungs were harvested 3 weeks after the irradiation, whole RNA was extracted and detected
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Immuno-Biochemical Impacts of Gamma Irradiation in Male Rats: A Dose-Response Study. Dose-Response (IF 2.5) Pub Date : 2023-06-21 Soha M Hussien,Engy R Rashed
During radiotherapy, immune-modulatory effects of radiation doses should be taken into consideration, not only the anti-tumor radiation effects. Thus, our study aimed to study how γ-radiation modulates immune response in comparison to common immune-suppressive/stimulant agents. Animals were divided into two groups. Category A received Echinacea purpura extract (EP) or irradiated at low radiation doses
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Antioxidant Potential and Improvement Activities of Sterculia setigera Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of Streptozotocin. Dose-Response (IF 2.5) Pub Date : 2023-06-19 Zacharie Tchoubou,Benoît Bargui Koubala,Dieudonné Ndjonka
Background S. setigera is widely used in traditional medicine throughout the world. Ethnobotanical surveys have revealed its use to handle diabetes. This present research investigated the antioxidant potential and improvement activities of S. setigera Delile on insulin resistance in type 2 diabetic rats. Methods Male rats fed high-fat diet for 6 weeks followed by a single-dose intraperitoneal injection
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Differential In Vivo Effects on Cancer Models by Recorded Magnetic Signals Derived From a Healing Technique. Dose-Response (IF 2.5) Pub Date : 2023-06-02 William Bengston,Paul Cizdziel,Akane Tanaka,Hiroshi Matsuda
Previous research on "healing-with-intent" has reasonably demonstrated the validity of the phenomenon at least when a human healer is present and involved. However, in order for healing to be adopted into more conventional therapies, it must be able to be made scalable. The present study tests the effects of a scalable recording of the Bengston Healing Method on 3 cancer models. BalbC mice engrafted
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Anti-Obesity Actions of Two Separated Aqueous Extracts From Arbutus (Arbutus unedo) and Hawthorn (Crataegus monogyna) Fruits Against High-Fat Diet in Rats via Potent Antioxidant Target. Dose-Response (IF 2.5) Pub Date : 2023-05-30 Soumaya Wahabi,Kais Rtibi,Amal Atouani,Hichem Sebai
Arbutus unedo and Crataegus monogyna are widely distributed throughout the Mediterranean basin and commonly used in folk medicine against a wide range of diseases. Therefore, the present study has been designed to evaluate the anti-obesity potential of two aqueous extracts of the fruits of A. unedo (AUAE) and C. monogyna (CMAE). Male Wistar rats were supplied with a standard diet (SD), high-fat diet
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Protective Effect of Tunisian Red Seaweed (Corallina officinalis) Against Bleomycin-Induced Pulmonary Fibrosis and Oxidative Stress in Rats. Dose-Response (IF 2.5) Pub Date : 2023-05-30 Jihen Dhaouafi,Anouar Abidi,Naima Nedjar,Montassar Romdhani,Haifa Tounsi,Hichem Sebai,Rafik Balti
Idiopathic pulmonary fibrosis is a chronic and progressive respiratory disease whose diagnosis and physiopathogenesis are still poorly understood and for which, until recently, there were no effective treatments. Over the past few decades, many studies have demonstrated that marine macroalgae such as red seaweeds are potential alternative sources of useful bioactive compounds possessing various physiological
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Protective Effect of Trillium tschonoskii Maxim Components Against Glutamate-Induced SH-SY5Y Cells Damage Through Regulating Apoptosis. Dose-Response (IF 2.5) Pub Date : 2023-05-29 Yanwen Li,Xingnan Yue,Shuo Wang,Pengyue Li,Man Zhang,Kuokui Song,Xiulan Huang,Zhiyong Li
Context Among the Tujia people, the root or rhizome of Trillium tschonoskii Maxim.in Bull.Acad (TTM) is considered a miraculous herb for headaches. Previous studies have shown ethyl acetate extract (TTM1) can protect SH-SY5Y cells against glutamate injury. Objective This study clarified TTM1's mechanism against glutamate-induced cell damage, focusing on the regulation of apoptosis. The compounds were
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Expression of Concern: "Optimization of Thymoquinone-Loaded Self-Nanoemulsion for Management of Indomethacin-Induced Ulcer". Dose-Response (IF 2.5) Pub Date : 2023-05-29
Sage Publishing and the Journal Editor hereby issue an expression of concern for the following article:Radwan MF, El-Moselhy MA, Alarif WM, Orif M, Alruwaili NK, Alhakamy NA. Optimization of Thymoquinone-Loaded Self-Nanoemulsion for Management of Indomethacin-Induced Ulcer. Dose-Response. 2021;19(2). doi:10.1177/15593258211013655Sage Publishing was made aware of a PubPeer post that cited concerns over
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Beneficial Effect of Rosuvastatin Therapy on Spleen Injury Induced by Gamma Irradiation in Rats: Targeting Nrf2/EPRE Pathway. Dose-Response (IF 2.5) Pub Date : 2023-05-27 Thanaa M Fahim,Marwa Abd El-Hameed Mohamed,Sahar S M Abdelrahman,Dina M Lotfy
Purpose The present study investigates the new approach of rosuvastatin (RUV) administration as a drug for the management of spleen injury induced by gamma irradiation. Main Methods Forty rats were used and divided equally into 4 groups: control group, irradiated group, IRR + rosuvastatin group (10 mg/Kg b. wt), and IRR + rosuvastatin group (20 mg/kg b. wt) for 7 days orally. Results The possible curative
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Endoplasmic Reticulum Stress Could Predict the Prognosis of Cervical Cancer and Regulate the Occurrence of Radiation Mucositis Dose-Response (IF 2.5) Pub Date : 2023-05-11 Xue Liu, Jing Song, Hui Liu, Zhiqiang Sun, Huiwen Ren, Judong Luo
The endoplasmic reticulum (ER) is an important cellular organelle, and ER dysfunction has an important impact on a variety of biological processes. In this study, we explored the role of ER stress ...
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Important Methodological Concern Regarding the Article "Effect of Leg Half-Squat Training With Blood Flow Restriction Under Different External Loads on Strength and Vertical Jumping Performance in Well-Trained Volleyball Players": A Letter to the Editor. Dose-Response (IF 2.5) Pub Date : 2023-04-26 Nicholas Rolnick,Okan Kamis
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Radiation Protection of Polydatin Against Radon Exposure Injury of Epithelial Cells and Mice Dose-Response (IF 2.5) Pub Date : 2023-04-24 Huiqin Chen, Fajian Luo, Huisheng Song, Huiqiang Long, Na Chen, Liang Sun, Fengmei Cui, Jun Wan, Yu Tu
Radon exposure is significantly associated with lung cancer. Radon concentration is currently reduced mainly by physical methods, but there is a lack of protective drugs or biochemical reagents for...
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Biphasic Dose-Response of Mn-Induced Mitochondrial Damage, PINK1/Parkin Expression, and Mitophagy in SK-N-SH Cells Dose-Response (IF 2.5) Pub Date : 2023-04-21 Yue Zhang, Hong-Tao Hu, Yu-Min Cao, Zhi-Gang Jiang, Jie Liu, Qi-Yuan Fan
Excessive manganese (Mn) exposure produces neurotoxicity with mitochondrial damage. Mitophagy is a protective mechanism to eliminate damaged mitochondria to protect cells. The aim of this study was...
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Local Diagnostic Reference Levels for Common Adult Computed Tomography Procedures in Addis Ababa Dose-Response (IF 2.5) Pub Date : 2023-04-19 Seife Teferi Dellie, Ambaye Fisehaw Tesfaw, Marema Jebessa Kumsa, Birhanu Turi Tolawak
BackgroundComputed Tomography has become the major source of population exposure in diagnostic x-rays. This concerned issue will be resolved by stetting Local Diagnostic Reference Levels.Objectives...
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Antiproliferative Activities of Acetone Extract From Canarium Odontophyllum (Dabai) Stem Bark Against Human Colorectal Cancer Cells Dose-Response (IF 2.5) Pub Date : 2023-04-14 Siti Fairuz Ishak, Nor Fadilah Rajab, Dayang Fredalina Basri
Colorectal cancer is the most common malignant cancer in developing countries. Canarium odontophyllum, also known as “Dabai” or “Borneo Olive“ is among the natural plants that can potentially be us...
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Anxiolytic and Antidepressant Potential of Methanolic Extract of Neurada procumbens Linn. in Mice Dose-Response (IF 2.5) Pub Date : 2023-04-13 Ahmed Awais Khalid, Qaiser Jabeen, Faraza Javaid
Neurada procumbens Linn. possesses a wide range of phytochemical and bioactive entities such as flavonoids and polyphenols that decrease the oxidative stress and enhance synaptic plasticity, result...
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MCNPX Estimation of Photoneutron Dose to Eye Voxel Anthropomorphic Phantom From 18 MV Linear Accelerator Dose-Response (IF 2.5) Pub Date : 2023-04-12 Ali AA Alghamdi
The dose due to photoneutron contamination outside the field of irradiation can be significant when using high-energy linear accelerators. The eye is a radiation-sensitive organ, and this risk incr...
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Evaluation of Brown Micro-Algae Synergies With Low Dose γ-Radiation Against Chronic Hepatitis Induced by D-Galactosamine in Rats Dose-Response (IF 2.5) Pub Date : 2023-04-11 Salma Elsaman, Sawsan M. Elsonbaty, Fatma S. M. Moawed, Marwa G. A. Hegazy
IntroductionHepatic inflammation is considered key driver of hepatic tissue impairment.We aimed to explore the interaction of Halamphora coffeaeformis (Amph.) with low dose ionizing γ radiation (γR...
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Retraction Notice: "Human Brain-Derived Neurotrophic Factor Gene-Modified Bone Marrow Mesenchymal Stem Cells Combined With Erythropoietin Can Improve Acute Spinal Cord Injury". Dose-Response (IF 2.5) Pub Date : 2023-04-13
[This retracts the article DOI: 10.1177/1559325820910930.].
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MicroRNA-146a Improved Acute Lung Injury Induced by hepatic Ischemia-reperfusion Injury by Inhibiting PRDX1 Dose-Response (IF 2.5) Pub Date : 2023-04-11 Yiping Xu, Yili Chen, Mengxia Yao, Yisheng You, Bin Nie, Meina Zeng, Hui Jiang
Hepatic ischemia-reperfusion injury (HIRI)–induced acute lung injury (ALI) is characterized by high incidence and poor prognosis. The regulatory role of microRNA-146a (miR-146a) in HIRI has been re...
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Dose Dependent Effects of Aqueous Extract of Garcinia cambogia Desr. Against Letrozole Induced Polycystic Ovarian Syndrome in Female Adult Rats With Possible Mechanisms Exploration Dose-Response (IF 2.5) Pub Date : 2023-04-10 Saba Rana, Liaqat Hussain, Uzma Saleem, Muhammad Asif, Arslan H. Lodhi, Muhammad Q. Barkat, Muhammad Riaz, Alina Jamil
BackgroundPolycystic ovarian syndrome (PCOS) is an endocrine metabolic disorder of women.PurposeThis study aimed to explore the potential of aqueous extract of Garcinia cambogia Desr. (AEGC) in PCO...
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Polymeric Membranes of Chitosan/Aloe Vera Gel Fabrication With Enhanced Swelling and Antimicrobial Properties for Biomedical Applications Dose-Response (IF 2.5) Pub Date : 2023-04-07 Dure N. Iqbal, Atira Munir, Mazhar Abbas, Arif Nazir, Zahid Ali, Samar Z. Alshawwa, Munawar Iqbal, Naveed Ahmad
Since ancient times, medicinal plants have been used as traditional medicine to treat a variety of ailments. Aloe vera (AV) gel’s therapeutic potential is one of the most effective approach in the ...
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Protective Effects of Resveratrol Against Adenomyosis in a Mouse Model Dose-Response (IF 2.5) Pub Date : 2023-03-19 Bo Zhu, Chenhui Zhang, Xiaolu Shen, Cong Chen, Xuanyu Chen, Yiyi Lu, Yumei Chen, Min Guo
Adenomyosis is a uterine condition in which endometrial glands and stroma are commonly pathologically observed in the myometrium. In this study, we sought to determine the effect of resveratrol on ...
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Evaluation of Phytochemical Contents, Antimicrobial, and antioxidant Potential of Haloxylon Griffithii Collected From Northern Region of Balochistan, Pakistan Dose-Response (IF 2.5) Pub Date : 2023-03-16 Rizwan Asif, Muhammad Ali, Modasrah Mazhar, Madiha Mustafa, Riffat Yasmin
BackgroundThe therapeutic potential of Haloxylon griffithii found in northern region of Balochistan, so far has been neglected.PurposeThe current study was aimed to assess the phytochemicals and ph...
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Second Dose Measles Vaccination Utilization and Associated Factors in Jabitehnan District, Northwest Ethiopia Dose-Response (IF 2.5) Pub Date : 2023-03-10 Aynalem Demewoz, Moges Wubie, Muluye Gebrie Mengie, Esmelealem Mihretu Kassegn, Dubie Jara, Abiot Aschale, Bekalu Endalew
BackgroundHerd immunity against measles is essential to interrupt measles transmission, and this can only be attained by reaching at least 95% coverage for each of the 2 doses of measles vaccine pr...
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The Extract of Acanthopanacis Cortex Relieves the Depression-Like Behavior and Modulates IL-17 Signaling in Chronic Mild Stress-Induced Depressive Mice Dose-Response (IF 2.5) Pub Date : 2023-02-26 Chuhan Liu, Lu Yan, Yiyun Qian, Pingping Song, Tao Wang, Min Wei
BackgroundAcanthopanacis Cortex (AC) is a valuable Chinese medicine, which exerts beneficial effects on anti-fatigue, anti-stress, and inflammatory modulation in the periphery. However, the central...
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Esketamine Anesthetizes Mice With a Similar Potency to Racemic Ketamine Dose-Response (IF 2.5) Pub Date : 2023-02-11 Xiaofan Ma, Jiali Peng, Yelin Chen, Zeyi Wang, Qiang Zhou, Jia Yan, Hong Jiang
Esketamine, the right-handed optical isomer of racemic ketamine, has recently become widely used for anesthesia and analgesia as a replacement for racemic ketamine. However, there are limited studi...
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Low-Dose Radiation Reduces Doxorubicin-Induced Myocardial Injury Through Mitochondrial Pathways Dose-Response (IF 2.5) Pub Date : 2023-02-11 Di Zhao, Xin Jiang, Xinxin Meng, Dandan Liu, Yanwei Du, Lijing Zhao, Hongyu Jiang
The use of doxorubicin (DOX) as an anthraquinone antineoplastic agent is limited due to its cardiotoxicity. Our previous study suggested that low-dose radiation (LDR) could mitigate the cardiotoxic...
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Apigenin and Exposure to Low Dose Gamma Radiation Ameliorate Acetic Acid-Induced Ulcerative Colitis in Rats Dose-Response (IF 2.5) Pub Date : 2023-02-03 Eman E. Shibrya, Rasha R. Rashed, Mai A. Abd El Fattah, Mona A. El-Ghazaly, Sanaa A. Kenawy
Ulcerative colitis (UC) is an inflammatory bowel disease involving chronic and recurring colon inflammation. Current management protocols are limited by adverse effects or short-term symptomatic re...
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Magnesium Sulfate Reduces Carrageenan-Induced Rat Paw Inflammatory Edema Via Nitric Oxide Production Dose-Response (IF 2.5) Pub Date : 2023-02-02 Dragana Srebro, Branko Dožić, Katarina Savić Vujović, Branislava Medić Brkić, Sonja Vučković
BackgroundMagnesium is an antagonist of the N-methyl-D-aspartate receptor. This study aimed to investigate the anti-edematous effect of magnesium sulfate (MS) in different protocols of use and the ...
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Poly Lactic-Co-Glycolic Acid Nano-Carriers for Encapsulation and Controlled Release of Hydrophobic Drug to Enhance the Bioavailability and Antimicrobial Properties Dose-Response (IF 2.5) Pub Date : 2023-01-30 Attaullah Bukhari, Zuha Fatima, Madiha Atta, Arif Nazir, Samar Z. Alshawwa, Hadil F. Alotaibi, Munawar Iqbal
This study focusses on the fabrication of nano-carriers for delivery of ciprofloxacin through the nanoprecipitation process. This was done to examine the release of drug at the pH of stomach to fin...
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Hydromethanolic Root Extract of Gnidia Kraussiana Demonstrates Anti-Inflammatory Effect Through Anti-Oxidant Activity Enhancement in a Rodent Model of Gout Dose-Response (IF 2.5) Pub Date : 2023-01-29 Elizé Dadaya, Benoit Koubala, Dieudonné Ndjonka, Stéphane Zingué, Alphonse Laya, Gisèle Atsang
Gout is a metabolic arthritis that originates from increased accumulation of monosodium urate (MSU) crystals in joints. This work aimed to evaluate the antioxidant and anti-inflammatory activities ...
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Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension Dose-Response (IF 2.5) Pub Date : 2023-01-12 Adnan Akram, Ayesha Jamshed, Mariya Anwaar, Hafiz Muhammad Farhan Rasheed, Syed Ihtisham Haider, Naveed Aslam, Qaiser Jabeen
Obesity, a chronic metabolic condition, is an increase in fat mass and blood lipid levels mainly causing atherosclerosis and hypertension, which further lead to cardiovascular complications. The ob...
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Dose Dependence of the Separate and Combined Impact of Copper-Oxide and Selenium-Oxide Nanoparticles on Oxygen Consumption by Cells In Vitro With or Without the Background Action of Some Modulators of the Mitochondrial Respiratory Function Dose-Response (IF 2.5) Pub Date : 2023-01-06 Tatiana V. Bushueva, Vladimir G. Panov, Ilzira A. Minigalieva, Larisa I. Privalova, Maria S. Vedernikova, Vladimir B. Gurvich, Marina P. Sutunkova, Boris A. Katsnelson
We had previously demonstrated on various stable cell cultures exposed to chemically different nanoparticles when assessing their cytotoxicity by different outcomes, dose-response relationships may...
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Can Low-Level Ionizing Radiation Do Us Any Harm? Dose-Response (IF 2.5) Pub Date : 2023-01-05 Marek K. Janiak, Michael P. R. Waligórski
The current system of radiological protection relies on the linear no-threshold (LNT) hypothesis of cancer risk due to humans being exposed to ionizing radiation (IR). Under this tenet, effects of ...
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New Insights Into the Anticancer Effects of p-Coumaric Acid: Focus on Colorectal Cancer Dose-Response (IF 2.5) Pub Date : 2023-01-04 Wafâa Tehami, Abdelhafid Nani, Naim A. Khan, Aziz Hichami
Colorectal cancer is considered the second most deadly cancer in the world. Studies have indicated that diet can prevent the risk of developing colorectal cancer. Recently, there has been an increa...
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Effect of Diammonium Glycyrrhizinate in Improving Focal Cerebral Ischemia-Reperfusion Injury in Rats Through Multiple Mechanisms Dose-Response (IF 2.5) Pub Date : 2022-12-01 Hong Wang, Binbin Zhang, Weiwei Dong, Yuying Li, Liwen Zhao, Ying Zhang
ObjectiveAcute ischemic stroke is a current major disabling and killer disease worldwide. We aimed to investigate the protective effect and mechanism of diammonium glycyrrhizinate in alleviating ac...
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Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis Dose-Response (IF 2.5) Pub Date : 2022-11-24 Zhuo Li, Xiaomin Hou, Xuehua Liu, Linlin Ma, Jiewen Tan
Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we’ve conducted a systemic proteomic analysis to...
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Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches Dose-Response (IF 2.5) Pub Date : 2022-11-23 Krzysztof W. Fornalski, Łukasz Adamowski, Ernest Bugała, Rafał Jarmakiewicz, Marek Kirejczyk, Jakub Kopyciński, Julianna Krasowska, Piotr Kukulski, Łukasz Piotrowski, Julia Ponikowska, Joanna Reszczyńska, Iwona Słonecka, Paweł Wysocki, Ludwik Dobrzyński
This review article describes our simplified biophysical model for the response of a group of cells to ionizing radiation. The model, which is a product of 10 years of studies, acts as (a) a compre...