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Pleiotropic beneficial cardiometabolic actions of a high-purity eicosapentaenoic acid product in high cardiovascular risk individuals Lipids (IF 1.9) Pub Date : 2024-02-21 Charalampos I. Liakos, Leonidas Lanaras, Magdalini Bristianou, Dimitrios P. Papadopoulos
The ideal approach to the secondary dyslipidemia goal of lowering triglycerides (TG) is not well established. The available ω-3 fatty acid products differ from each other in composition and content. The purpose of the present study was to investigate the effect of a highly purified eicosapentaenoic acid (EPA) formulation on cardiometabolic biomarkers in high cardiovascular (CV) risk patients. The study
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Plasma sphingolipids in patients with sickle cell disease: Multiple-site vaso-occlusive crises could be associated with lower sphingolipid levels Lipids (IF 1.9) Pub Date : 2024-02-08 Gokce Alp, Yesim Oztas, Ahmet Yalcinkaya, Selinay Ozel, Nazim Yildirim, Selma Unal
Although sickle cell disease (SCD) and its manifestations have been associated with various lipid alterations, there are a few studies exploring the impact of sphingolipids in SCD. In this study, we determined plasma ceramide (Cer) and sphingomyelin (CerPCho) species and investigated their association with the crisis in SCD. SCD patients (N = 27) suffering from vaso-occlusive crisis (VOC) or acute
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Alteration of serum bile acids in amyotrophic lateral sclerosis Lipids (IF 1.9) Pub Date : 2024-02-06 Ikjae Lee, Renu Nandakumar, Rebecca A. Haeusler
Hydrophilic endogenous bile acids ursodeoxycholic acid (UDCA), tauroursodeoxycholic acid (TUDCA), and glucourosodeoxycholic acid (GUDCA) have suggested neuroprotective effects. We performed a case–control study to examine the association between ALS diagnosis and serum levels of bile acids. Sporadic and familial ALS patients, age- and sex-matched healthy controls, and presymptomatic gene carriers who
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A lipidomics approach reveals novel phospholipid changes in palmitate-treated C2C12 myotubes Lipids (IF 1.9) Pub Date : 2024-02-01 Wakako Tawara, Mizuki Morisasa, Risa Mukai, Rei Suo, Shiro Itoi, Tsukasa Mori, Naoko Goto-Inoue
Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disorder. Insulin resistance and oxidative stress are associated with T2DM development. The hypothesis that patients with T2DM show excess accumulation of lipids, such as ceramides (Cers) and diacylglycerols (DAGs), in their skeletal muscles has been widely supported; however, detailed lipidomic data at the molecular species level are
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Role of dietary intake of specific polyunsaturated fatty acids (PUFAs) on colorectal cancer risk in Iran Lipids (IF 1.9) Pub Date : 2024-01-29 Monireh Sadat Seyyedsalehi, Maryam Hadji, Giulia Collatuzzo, Hamideh Rashidian, Bahareh Sasanfar, Inge Huybrechts, Veronique Chajes, Paolo Boffetta, Kazem Zendehdel
High-fat diets have been associated with colorectal cancer (CRC) risk, and the role of polyunsaturated fatty acids (PUFAs) has been reported to vary based on the length of PUFAs. We explored the association between dietary omega-6 and omega-3 PUFAs intake and CRC. We analyzed 865 CRC patients and 3206 controls from a case–control study of Iran (IROPICAN study). We used multivariate logistic regression
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Sex-specific association between monocyte to high-density lipoprotein cholesterol and extensive abdominal aortic calcification in humans Lipids (IF 1.9) Pub Date : 2024-01-28 Yuyu Niu, Guifang Wang, Xianjun Feng, Hongyi Niu, Wenrui Shi, Yingxue Shen
Recent studies have identified monocyte-to-high-density lipoprotein cholesterol ratio (MHR) as a simple marker of atherosclerosis. Abdominal aortic calcification (AAC) is a direct result of vascular atherosclerosis. Our study aims to investigate the association between MHR and the prevalent extensive AAC and assess the value of MHR for identifying prevalent extensive AAC. 2857 subjects (28.07%) from
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The futile creatine cycle and the synthesis of fatty acids in inguinal white adipose tissue from growing rats, submitted to a hypoprotein-hyperglycidic diet for 15 days Lipids (IF 1.9) Pub Date : 2024-01-15 Edgar Willibaldo Allebrandt Neto, Jadyellen Rondon e Silva, Stephanie Figueiredo Santos, Suélem Aparecida de França Lemes, Nair Honda Kawashita, Mayara Peron Pereira
The low-protein, high-carbohydrate (LPHC) diet administered to growing rats soon after weaning, for 15 days, promoted an increase in energy expenditure by uncoupling protein 1 (UCP1) in interscapular brown adipose tissue, and also due to the occurrence of the browning process in the perirenal white adipose tissue (periWAT). However, we believe that inguinal white adipose tissue (ingWAT) may also contribute
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Dietary linoleic acid lowering alone does not lower arachidonic acid or endocannabinoids among women with overweight and obesity: A randomized, controlled trial Lipids (IF 1.9) Pub Date : 2023-12-15 Amber B. Courville, Sharon Majchrzak-Hong, Shanna Yang, Sara Turner, Breanne Wilhite, Katherine Ness Shipley, Yvonne Horneffer, Anthony F. Domenichiello, Melanie Schwandt, Roy G. Cutler, Kong Y. Chen, Joseph R. Hibbeln, Christopher E. Ramsden
The linoleic acid (LA)-arachidonic acid (ARA)-inflammatory axis suggests dietary LA lowering benefits health because it lowers ARA and ARA-derived endocannabinoids (ECB). Dietary LA reduction increases concentrations of omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DHA derived ECB. The aim of this study was to examine targeted reduction of dietary LA, with and without EPA and
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Study of sample preparation influence on bacterial lipids profile in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Lipids (IF 1.9) Pub Date : 2023-12-07 Adrian Arendowski, Ewelina Sibińska, Wioletta Miśta, Piotr Fijałkowski, Michał Złoch, Dorota Gabryś, Paweł Pomastowski
Lipids are one of the cell components therefore it is important to be able to accurately assess them. One of the analytical techniques used to study lipid profiles is matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS). The present study attempted to select optimal conditions for sample preparation and MALDI MS analysis of bacterial lipidome in both positive
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Dietary triacetin, but not medium chain triacylglycerides, blunts weight gain in diet-induced rat model of obesity Lipids (IF 1.9) Pub Date : 2023-11-24 Giulia Cisbani, Raphaël Chouinard-Watkins, Mackenzie E. Smith, Arezou Malekanian, Rodrigo Valenzuela, Adam H. Metherel, Richard P. Bazinet
Consumption of a Western diet (WD) is known to increase the risk of obesity. Short or medium chain fatty acids influence energy metabolism, and triacetin, a synthetic short chain triacylglyceride, has been shown to lower body fat under normal conditions. This study aimed to investigate if triacetin as part of a WD modifies rat weight and body fat. Male rats were fed a control diet or WD for 8 weeks
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9-POHSA prevents NF-kB activation and ameliorates LPS-induced inflammation in rat hepatocytes Lipids (IF 1.9) Pub Date : 2023-08-21 Jiro Hasegawa Situmorang, Ming-Cheng Chen, Wei-Wen Kuo, Shinn-Zong Lin, Cheng-Yen Shih, Pi-Yu Lin, Ching-Hui Loh, Chih-Yang Huang
Liver inflammation has become increasingly prevalent in recent years, leading to the development of diseases like hepatitis, alcoholic liver disease, and fatty liver disease. One factor that has been linked to liver inflammation is increased levels of lipopolysaccharides (LPS), which can be caused by poor diets and sedentary lifestyles that contribute to liver inflammation. There is promising research
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Correction to “Consumption of synbiotic bread decreases triacylglycerol and VLDL levels while increasing HDL levels in serum from patients with type-2 diabetes” Lipids (IF 1.9) Pub Date : 2023-08-13
Shakeri, H, Hadaegh, H, Abedi, F, Tajabadi-Ebrahimi, M, Mazroii, N, Ghandi, Y and Asemi, Z. Consumption of synbiotic bread decreases triacylglycerol and VLDL levels while increasing HDL levels in serum from patients with type-2 diabetes. Lipids. 2014;49:695–701. https://doi.org/10.1007/s11745-014-3901-z. The journal is aware of a number of issues raised regarding the integrity of research published
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Correction to “Synbiotic food consumption reduces levels of triacylglycerols and VLDL, but not cholesterol, LDL, or HDL in plasma from pregnant women” Lipids (IF 1.9) Pub Date : 2023-08-12
Taghizadeh, M, Hashemi, T, Shakeri, H, Abedi, F, Sabihi, S-S, Alizadeh, S-A and Asemi, Z. Synbiotic food consumption reduces levels of triacylglycerols and VLDL, but not cholesterol, LDL, or HDL in plasma from pregnant women. Lipids. 2014;49:155–161. https://doi.org/10.1007/s11745-013-3867-2. The journal is aware of a number of issues raised regarding the integrity of research published by Zatolleh
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Antioxidants ameliorate oxidative stress in alcoholic liver injury by modulating lipid metabolism and phospholipid homeostasis Lipids (IF 1.9) Pub Date : 2023-08-07 Xiaoxu Wang, Bin Liu, Yanjun Liu, Yuliu Wang, Zhigao Wang, Yu Song, Jie Xu, Changhu Xue
Alcoholic liver disease (ALD) is a significant risk factor in the global disease burden. The antioxidants vitamin C (Vc) and N-acetyl cysteine (NAC) have shown hepatoprotective effects in preventing and treating ALD. However, the correlation between the improved effect of antioxidants and lipid metabolism is still unclear. In this study, AML12 cells and C57BL/6 mice stimulated with alcohol were used
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Dietary and plasma retinoids are not associated with fatty acid desaturase indices in healthy young adults Lipids (IF 1.9) Pub Date : 2023-06-13 Julia Hatherell, Salma A. Abdelmagid, David W. L. Ma, Ahmed El-Sohemy, David M. Mutch
Past research in rodents suggests that fatty acid (FA) desaturase expression and activity may be modified by vitamin A; however, this has not been investigated in humans. The primary objective of this study was to examine associations between dietary retinoid intakes, plasma retinoid concentrations, and FA desaturase indices in young adults. As a secondary objective, biological sex and estrogen-containing
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Very low Omega-3 Index in young healthy students from Palestine Lipids (IF 1.9) Pub Date : 2023-06-10 Feras Almasri, Manal Badrasawi, Rana Zahdeh, Andreas Hahn, Jan Philipp Schuchardt, Theresa Greupner
Oily fish is rich in long-chain omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which have been associated with several health benefits. However, fish consumption is generally low in many countries, including the Middle East, resulting in low omega-3 blood levels. In Palestine, no data on the omega-3 blood status is available. The aim of this
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Atherogenic dyslipidaemia in type 2 diabetes mellitus: The PREDISAT study Lipids (IF 1.9) Pub Date : 2023-06-08 Elisenda Climent, Jesús Millán, Juan F. Ascaso, Manuel Suárez-Tembra, Carlos Morillas, Fernando Civeira, Jose M. Bellón, Juan Pedro-Botet
Extremely variable prevalence rates of atherogenic dyslipidaemia (AD) in type 2 diabetes (T2DM) subjects have been reported. The primary aim was to assess AD prevalence in Spanish T2DM subjects. Secondary objectives were to evaluate the differential clinical characteristics between T2DM subjects with and without AD, to describe lipid profile evolution and use of lipid-lowering treatment in clinical
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Exogenous tetracosahexaenoic acid modifies the fatty acid composition of human primary T lymphocytes and Jurkat T cell leukemia cells contingent on cell type Lipids (IF 1.9) Pub Date : 2023-05-13 Nicola A. Irvine, Annette L. West, Johanna Von Gerichten, Elizabeth A. Miles, Karen A. Lillycrop, Philip C. Calder, Barbara A. Fielding, Graham C. Burdge
Tetracosahexaenoic acid (24:6ω-3) is an intermediate in the conversion of 18:3ω-3 to 22:6ω-3 in mammals. There is limited information about whether cells can assimilate and metabolize exogenous 24:6ω-3. This study compared the effect of incubation with 24:6ω-3 on the fatty acid composition of two related cell types, primary CD3+ T lymphocytes and Jurkat T cell leukemia, which differ in the integrity
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Association of circulating branched chain fatty acids with insulin sensitivity and beta cell function in the PROMISE cohort Lipids (IF 1.9) Pub Date : 2023-05-11 Nagam A. Yehia, Liridona Isai, Zhila Semnani-Azad, Kira Zhi Hua Lai, Ravi Retnakaran, Stewart B. Harris, Jacqueline L. Beaudry, Richard P. Bazinet, Anthony J. Hanley
Branched chain fatty acids (BCFAs) are mainly saturated fatty acids with a methyl branch on the penultimate or antepenultimate carbon atom. While BCFAs are endogenously produced via the catabolism of branched chain amino acids, the primary exogenous source of BCFAs in the human body is via the diet, including dairy products. Recently, BCFAs have been identified as having a potentially protective role
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Comparative performance of equations to estimate low-density lipoprotein cholesterol levels and cardiovascular disease incidence: The ATTICA study (2002–2022) Lipids (IF 1.9) Pub Date : 2023-05-08 Tzortzis Nomikos, Michael Georgoulis, Christina Chrysohoou, Evangelia Damigou, Fotios Barkas, Ioannis Skoumas, Evangelos Liberopoulos, Christos Pitsavos, Costas Tsioufis, Petros P. Sfikakis, Alexandros Tselepis, Demosthenes B. Panagiotakos
Accurate estimation of low-density lipoprotein cholesterol (LDL-C) is important for monitoring cardiovascular disease (CVD) risk and guiding lipid-lowering therapy. This study aimed to evaluate the magnitude of discordance of LDL-C levels calculated by different equations and its effect on CVD incidence. The study sample consisted of 2354 CVD-free individuals (49% males, mean age 45 ± 14 years); 1600
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Comparison of Ahiflower oil containing stearidonic acid to a high-alpha-linolenic acid flaxseed oil at two dietary levels on omega-3 enrichment of egg yolk and tissues in laying hens Lipids (IF 1.9) Pub Date : 2023-04-11 Ahmed S. A. El-Zenary, Robert G. Elkin, Kevin J. Harvatine
Enrichment of egg yolks with very long chain omega-3 fatty acids (VLCn-3 FA) is of interest because of their beneficial effects on human health. The ability of Ahiflower® oil (AHI; Buglossoides arvensis), which is naturally rich in stearidonic acid (SDA), and a high-alpha-linolenic acid (ALA) flaxseed (FLAX) oil to enrich eggs and tissues of laying hens with VLCn-3 FA was investigated. Forty 54-week-old
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Equal bioavailability of omega-3 PUFA from Calanus oil, fish oil and krill oil: A 12-week randomized parallel study Lipids (IF 1.9) Pub Date : 2023-03-24 Franziska Vosskötter, Milena Burhop, Andreas Hahn, Jan Philipp Schuchardt
The bioavailability of long-chain omega-3 polyunsaturated fatty acids (n3 PUFA) can be affected by the form in which they are bound. An alternative source of n3 PUFA is Calanus finmarchicus oil (CO), which, unlike fish oil (FO) and krill oil (KO), contains fatty acids primarily bound as wax esters. Recent studies have shown that n3 PUFA from CO are bioavailable to humans, but CO has not been compared
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Effects of fatty acid-ethanol amine (FA-EA) derivatives on lipid accumulation and inflammation Lipids (IF 1.9) Pub Date : 2023-03-21 Mengyu Li, Xiaoqing Huang, Mengxian Huang, Wenhui Jin, Zhuan Hong, Yucang Zhang, Hua Fang, Weizhu Chen
This study aimed to investigate the effect of fatty acid-ethanol amine (FA-EA) derivatives (L1–L10) on the mitigation of intracellular lipid accumulation and downregulation of pro-inflammatory cytokines in vitro. First, the series of FA-EA derivatives were synthesized and characterized. Then, their cytotoxic, intracellular lipid accumulation and inhibition of pro-inflammatory cytokines were evaluated
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Ceramide concentrations in liver, plasma, and very low-density lipoproteins of humans with severe obesity Lipids (IF 1.9) Pub Date : 2023-02-27 Kelli A. Lytle, Jin Ook Chung, Nikki C. Bush, Jessica M. Triay, Michael D. Jensen
We investigated the relationships between ceramide species concentrations in liver, plasma and very low-density lipoproteins (VLDL) particles of humans with obesity as well as the relationships between hepatic fat content and hepatic ceramide concentrations and proportional distribution. Twenty-five obese (body mass index >35 kg/m2) adults participated in this study. Plasma, VLDL and hepatocellular
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Hypoxia increases cellular levels of phosphatidic acid and lysophospholipids in undifferentiated Caco-2 cells Lipids (IF 1.9) Pub Date : 2023-01-28 Yoshibumi Shimizu, Keiko Tamiya-Koizumi, Toshihiko Tsutsumi, Mamoru Kyogashima, Reiji Kannagi, Soichiro Iwaki, Mineyoshi Aoyama, Akira Tokumura
Cancer cells are known to survive in a hypoxic microenvironment by altering their lipid metabolism as well as their energy metabolism. In this study, Caco-2 cells derived from human colon cancer, were found to have elevated intracellular levels of phosphatidic acid and its lysoform, lysophosphatidic acid (LPA), under hypoxic conditions. Our results suggested that the elevation of LPA in Caco-2 cells
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Enriched PUFA environment of Leishmania infantum promastigotes promotes the accumulation of lipid mediators and favors parasite infectivity towards J774 murine macrophages Lipids (IF 1.9) Pub Date : 2022-12-21 Marine Leroux, Hana Bouazizi-Ben Messaoud, Céline Luquain-Costaz, Lars P. Jordheim, Pauline Le Faouder, Marie-Paule Gustin, Karim Aoun, Philippe Lawton, Samira Azzouz-Maache, Isabelle Delton
Leishmania parasites are the causative agents of visceral or cutaneous leishmaniasis in humans and of canine leishmaniosis. The macrophage is the predilected host cell of Leishmania in which the promastigote stage is transformed into amastigote. We previously showed changes in the fatty acid composition (FA) of lipids in two strains of Leishmania donovani upon differentiation of promastigote to amastigote
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Geometrical and positional isomers of unsaturated furan fatty acids in food Lipids (IF 1.9) Pub Date : 2022-11-21 Franziska Müller, Tim Hammerschick, Walter Vetter
Furan fatty acids (FuFA) are important antioxidants found in low concentrations in many types of food. In addition to conventional FuFA which normally feature saturated carboxyalkyl and alkyl chains, a few previous studies indicated the FuFA co-occurrence of low shares of unsaturated furan fatty acids (uFuFA). For their detailed analysis, the potential uFuFA were enriched by centrifugal partition chromatography
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Olive oil promotes the survival and migration of dermal fibroblasts through Nrf2 pathway activation Lipids (IF 1.9) Pub Date : 2022-10-26 Bianca C. de S. Ribeiro, Regina V. de C. Faria, Jeane de S. Nogueira, Samuel Santos Valença, Lin Chen, Bruna Romana-Souza
Olive oil has beneficial effects on skin wound healing due to its anti-inflammatory and antioxidant properties; however, the mechanism by which olive oil promotes wound healing is unclear. We evaluated the mechanisms involved in Nrf2 pathway activation by olive oil and its role in cell survival and migration in mouse dermal fibroblasts in a short-term exposition. Our data demonstrated that olive oil
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Serum and diet long-chain omega-3 fatty acid nutritional status in Chinese elite athletes Lipids (IF 1.9) Pub Date : 2022-10-22 Qiuping Zhang, Qian Xu, Huajun Tian, Yudan Chu, Jun Qiu, Mengwei Sun
Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are essential for improving the health and performance of athletes. The present study aimed to evaluate the nutritional status of omega-3 PUFAs in Chinese elite athletes by both dietary intake analysis and serum biomarker detection. A cross-sectional analysis of data from 54 elite athletes (24 men and 30 women) from Shanghai professional sports teams
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Antibiotics administration alleviates the high fat diet-induced obesity through altering the lipid metabolism in young mice Lipids (IF 1.9) Pub Date : 2022-10-17 Shiyue Luo, Hongyang Zhang, Xuejun Jiang, Yinyin Xia, Shixin Tang, Xinhao Duan, Wei Sun, Min Gao, Chengzhi Chen, Zhen Zou, Lixiao Zhou, Jingfu Qiu
Currently, there is a global trend of rapid increase in obesity, especially among adolescents. The antibiotics cocktails (ABX) therapy is commonly used as an adjunctive treatment for gut microbiota related diseases, including obesity. However, the effects of broad-spectrum antibiotics alone on young obese hosts have rarely been reported. In the present study, the 3-week-old C57BL/6J male mice fed a
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GC–MS analysis of oxysterols and their formation in cultivated liver cells (HepG2) Lipids (IF 1.9) Pub Date : 2022-10-04 Elisabeth Koch, Mustafa Bagci, Michael Kuhn, Nicole M. Hartung, Malwina Mainka, Katharina M. Rund, Nils Helge Schebb
Oxysterols play a key role in many (patho)physiological processes and they are potential biomarkers for oxidative stress in several diseases. Here we developed a rapid gas chromatographic-mass spectrometry-based method for the separation and quantification of 11 biologically relevant oxysterols bearing hydroxy, epoxy, and dihydroxy groups. Efficient chromatographic separation (resolution ≥ 1.9) was
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Hydrolysis of polyhydroxy polyunsaturated fatty acid-glycerophosphocholines by Group IIA, V, and X secretory phospholipases A2 Lipids (IF 1.9) Pub Date : 2022-09-17 Arnis Kuksis, Waldemar Pruzanski
It is widely accepted that unesterified polyunsaturated ω-6 and ω-3 fatty acids (PUFA) are converted through various lipoxygenases, cyclooxygenases, and cytochrome P450 enzymes to a range of oxygenated derivatives (oxylipins), among which the polyhydroxides of unesterified PUFA have recently been recognized as cell signaling molecules with anti-inflammatory and pro-resolving properties, known as specialized
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Ergosterol increases 7-dehydrocholesterol, a cholesterol precursor, and decreases cholesterol in human HepG2 cells Lipids (IF 1.9) Pub Date : 2022-09-13 Naoko Kuwabara, Miho Ohta-Shimizu, Fumiko Fuwa, Eriko Tomitsuka, Shinji Sato, Saori Nakagawa
Current treatment approaches for hyperlipidemia rely mainly on reducing the cholesterol level by inhibiting 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), which is involved in the presqualene pathway of cholesterol biosynthesis. Finding a compound that instead targets the postsqualene pathway could aid in the treatment of hyperlipidemia and synergistically reduce the cholesterol level when used
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Glucocorticoids decrease thermogenic capacity and increase triacylglycerol synthesis by glycerokinase activation in the brown adipose tissue of rats Lipids (IF 1.9) Pub Date : 2022-09-13 Ana Paula Assis, Karine Emanuelle Silva, Natalia Lautherbach, Henrique Jorge Novaes Morgan, Maria Antonieta Rissato Garófalo, Neusa Maria Zanon, Luiz Carlos Carvalho Navegantes, Valéria Ernestânia Chaves, Isis do Carmo Kettelhut
Although it is well established that glucocorticoids inactivate thermogenesis and promote lipid accumulation in interscapular brown adipose tissue (IBAT), the underlying mechanisms remain unknown. We found that dexamethasone treatment (1 mg/kg) for 7 days in rats decreased the IBAT thermogenic activity, evidenced by its lower responsiveness to noradrenaline injection associated with reduced content
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Phosphatidylinositol 4,5-bisphosphate-specific phospholipase C β1 selectively binds dipalmitoyl and distearoyl phosphatidic acids via Lys946 and Lys951 Lipids (IF 1.9) Pub Date : 2022-09-02 Fumi Hoshino, Maika Nakayama, Masataka Furuta, Chiaki Murakami, Ayumu Kato, Fumio Sakane
Phospholipase C (PLC) β1 hydrolyzes 1-stearoyl-2-arachidonoyl (18:0/20:4)-phosphatidylinositol (PtdIns) 4,5-bisphosphate to produce diacylglycerol, which is converted to phosphatidic acid (PtdOH), in the PtdIns cycle and plays pivotal roles in intracellular signal transduction. The present study identified PLCβ1 as a PtdOH-binding protein using PtdOH-containing liposomes. Moreover, the comparison of
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α-linolenic acid interconversion is sufficient as a source of longer chain ω-3 polyunsaturated fatty acids in humans: An opinion Lipids (IF 1.9) Pub Date : 2022-07-31 Graham C. Burdge
α-linolenic acid (αLNA) conversion into the functionally important ω-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), has been regarded as inadequate for meeting nutritional requirements for these PUFA. This view is based on findings of small αLNA supplementation trials and stable isotope tracer studies that have been interpreted as indicating human
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The [13C]octanoic acid breath test for gastric emptying quantification: A focus on nutrition and modeling Lipids (IF 1.9) Pub Date : 2022-07-07 Johanna von Gerichten, Marwan H. Elnesr, Joe E. Prollins, Ishanki A. De Mel, Alan Flanagan, Jonathan D. Johnston, Barbara A. Fielding, Michael Short
Gastric emptying (GE) is the process of food being processed by the stomach and delivered to the small intestine where nutrients such as lipids are absorbed into the blood circulation. The combination of an easy and inexpensive method to measure GE such as the CO2 breath test using the stable isotope [13C]octanoic acid with semi-mechanistic modeling could foster a wider application in nutritional studies
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Correlation between adipocyte fatty acid binding protein and glucose dysregulation is closely associated with obesity and metabolic syndrome: A cohort of Han Chinese population from Yunnan plateau Lipids (IF 1.9) Pub Date : 2022-07-01 Juan Huang, Guo Chen, Qiao Zhang, Yanjiao Wang, Qiong Meng, Fang Xu, Xuehui Zhang, Wei Zou, Fei Mi, Jianzhong Yin
The present study investigated the correlation of plasma A-FABP with glucose dysregulation under different body mass index (BMI) and metabolic states in a Han Chinese population from Yunnan plateau. We cross-sectionally analyzed data from the China Multi Ethnic Cohort, Yunnan province. Participants were divided into two groups. Group A contained 297 obese individuals with metabolic syndrome (MetS)
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Structurally-engineered fatty acid 1024 (SEFA-1024) improves diet-induced obesity, insulin resistance, and fatty liver disease Lipids (IF 1.9) Pub Date : 2022-07-01 Jordon D. Secor, Bennet S. Cho, Lumeng J. Yu, Amy Pan, Victoria H. Ko, Duy T. Dao, Michael Feigh, Lorenzo Anez-Bustillos, Gillian L. Fell, David A. Fraser, Kathleen M. Gura, Mark Puder
Obesity is a global epidemic that drives morbidity and mortality through cardiovascular disease, diabetes, and non-alcoholic fatty liver disease (NAFLD). No definitive therapy has been approved to improve glycemic control and treat NAFLD in obese patients. Here, we investigated a semi-synthetic, long chain, structurally-engineered fatty acid-1024 (SEFA-1024), as a treatment for obesity-induced hyperglycemia
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Validation of lipid profile measurement methods and establishment of reference values in a sub-Saharan African population Lipids (IF 1.9) Pub Date : 2022-06-03 Cécile Danielle Tang Tsana, Guy Sadeu Wafeu, Vicky Jocelyne Ama Moor, Bertille Elodie Edinga-Melengue, Jan René Nkeck, Georges Nguefack-Tsague
Validated reference values and procedures are needed to ensure optimal diagnosis of dyslipidemia in sub-Saharan Africa. We aimed to validate an analysis method and establish reference intervals of lipid profile parameters in Cameroonians using this method. On a cross-sectional study conducted from November 2019 to August 2020 in Yaoundé, we have analyzed blood samples with Cobas® 6000. We subscribed
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Blue-green light is required for a maximized fatty acid unsaturation and pigment concentration in the microalga Acutodesmus obliquus Lipids (IF 1.9) Pub Date : 2022-04-22 Mark Helamieh, Marco Reich, Sophie Bory, Philipp Rohne, Ulf Riebesell, Martin Kerner, Klaus Kümmerer
Blue-green light is known to maximize the degree of fatty acid (FA) unsaturation in microalgae. However, knowledge on the particular waveband responsible for this stimulation of FA desaturation and its impact on the pigment composition in microalgae remains limited. In this study, Acutodesmus obliquus was cultivated for 96 h at 15°C with different light spectra (380–700 nm, 470–700 nm, 520–700 nm,
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Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes Lipids (IF 1.9) Pub Date : 2022-03-23 Mariona Rabionet, Pauline Bernard, Melanie Pichery, Christian Marsching, Aline Bayerle, Shaalee Dworski, Mustafa A. Kamani, Chandramohan Chitraju, Nina L. Gluchowski, Katlyn R. Gabriel, Abolfazl Asadi, Philipp Ebel, Menno Hoekstra, Sabrina Dumas, James M. Ntambi, Anders Jacobsson, Klaus Willecke, Jeffrey A. Medin, Nathalie Jonca, Roger Sandhoff
1-O-Acylceramides (1-OACs) have a fatty acid esterified to the 1-hydroxyl of the sphingosine head group of the ceramide, and recently we identified these lipids as natural components of human and mouse epidermis. Here we show epidermal 1-OACs arise shortly before birth during the establishment of the water permeability barrier in mice. Fractionation of human epidermis indicates 1-OACs concentrate in
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2-Arachidonoyl glycerol suppresses gastric emptying via the cannabinoid receptor 1-cholecystokinin signaling pathway in mice Lipids (IF 1.9) Pub Date : 2022-03-10 Keita Ochiai, Rina Hirooka, Masayoshi Sakaino, Shigeo Takeuchi, Tohru Hira
2-Monoacylglycerol (2-MAG) is one of the digestion products of dietary lipids. We recently demonstrated that a 2-MAG, 2-arachidonoyl glycerol (2-AG) potently stimulated cholecystokinin (CCK) secretion via cannabinoid receptor 1 (CB1) in a murine CCK-producing cell line, STC-1. CCK plays a crucial role in suppressing postprandial gastric emptying. To examine the effect of 2-AG on gastric emptying, we
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MCFA alleviate H2O2-induced oxidative stress in AML12 cells via the ERK1/2/Nrf2 pathway Lipids (IF 1.9) Pub Date : 2022-03-09 Danping Wang, Jinglong Chen, Huangbing Sun, Wenjing Chen, Xiaojing Yang
Oxidative stress is an important factor in the occurrence and development of liver disease. Medium-chain fatty acids (MCFAs) have potential antioxidant function, whereas the exact underlying mechanism of MCFA in oxidative injury of hepatocytes remains unclear. In our present study, three different MCFAs, 8-carbon octanoic acid (OA), 10-carbon capric acid (CA), and 12-carbon lauric acid (LA), have been
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Serum β-carotene concentrations are associated with self-reported fatty acid intake in United States adults from the National Health and Examination Surveys Lipids (IF 1.9) Pub Date : 2022-03-08 Ambria C. Crusan, Marla Reicks, Ryan T. Demmer, Susan K. Raatz
Bioavailability of dietary β-carotene (BC) is dependent on dose, quantity, dispersion, and presence of fat in the diet. Fats are comprised of a variety of fatty acids, which may impact the bioavailability of carotenoids. However, there is a gap in research on whether specific fatty acid classes affect serum BC concentrations in population samples. The primary objective of this study was to assess the
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Docosahexaenoic acid and arachidonic acid levels are correlated in human milk: Implications for new European infant formula regulations Lipids (IF 1.9) Pub Date : 2022-02-15 Kathryn E. Hopperton, Michael A. Pitino, Kathryn Walton, Alex Kiss, Sharon L. Unger, Deborah L. O'Connor, Richard P. Bazinet
From February 2022, all infant formula sold in the European Union must contain docosahexaenoic acid (DHA) at ~0.33%–1.14% of total fat with no minimum requirement for arachidonic acid (ARA). This work examines the association between DHA and ARA levels in human milk, the gold standard for infant feeding. Human milk (n = 470) was collected over 12-weeks postpartum from lactating mothers (n = 100) of
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Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long-term cannabis users: A secondary analysis of a case–control study Lipids (IF 1.9) Pub Date : 2022-01-24 Giulia Cisbani, Alex Koppel, Adam H. Metherel, Mackenzie E. Smith, Kankana N. Aji, Ana C. Andreazza, Romina Mizrahi, Richard P. Bazinet
Cannabis is now legal in many countries and while numerous studies have reported on its impact on cognition and appetite regulation, none have examined fatty acid metabolism in young cannabis users. We conducted an exploratory analysis to evaluate cannabis impact on fatty acid metabolism in cannabis users (n = 21) and non-cannabis users (n = 16). Serum levels of some saturated and monounsaturated fatty
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Lipid profile, lipid ratios, apolipoproteins, and risk of cardiometabolic multimorbidity in men: The Kuopio Ischaemic Heart Disease Risk Factor Study Lipids (IF 1.9) Pub Date : 2022-01-20 Behnam Tajik, Ari Voutilainen, Jussi Kauhanen, Moshen Mazidi, Gregory Y. H. Lip, Tomi-Pekka Tuomainen, Masoud Isanejad
The blood level of lipids, apolipoproteins, and lipid ratios are important predictors of some chronic diseases. However, their association with cardiometabolic multimorbidity (CMM) is less known. We evaluated a wide range of lipid profiles and lipid ratios, including low-density lipoprotein-cholesterol (LDL-C), very-low-density lipoprotein-cholesterol (VLDL-C), high-density lipoprotein-cholesterol
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Enrichment of n-3 containing ether phospholipids in plasma after 30 days of krill oil compared with fish oil supplementation Lipids (IF 1.9) Pub Date : 2022-01-03 Hyunsin (Hedy) Sung, Andrew J. Sinclair, Xiao Q Su
There are conflicting findings over the bioavailability of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) from krill oil (KO) compared with fish oil (FO) in short- and long-term studies. The aim of this study was to compare the effects of KO versus FO on the enrichment of molecular species of plasma phospholipids in young women following a 30-day consumption of the n-3 oils. Eleven healthy women
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Genetic variants in SLC22A1 are related to serum lipid levels in Mexican women Lipids (IF 1.9) Pub Date : 2021-12-19 José Ángel Cahua-Pablo, Jaime Héctor Gómez-Zamudio, Carlos Alberto Reséndiz-Abarca, Vianet Argelia Tello-Flores, Yesica Eulogio-Metodio, Marco Antonio Ramírez-Vargas, Miguel Cruz, Luz del Carmen Alarcón-Romero, Inés Matia-García, Linda Anahí Marino-Ortega, Ma. Isabel Zubillaga-Guerrero, Eugenia Flores-Alfaro
Dyslipidemia is the main risk factor for coronary artery disease and is characterized by alterations in concentrations of lipids, including low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and triacylglycerols. The participation of several genes in the development of dyslipidemia has been evidenced. Genetic variants in SLC22A1 have been associated with elevated
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Destruction of polyunsaturated alkyl/acyl and alkenyl/acyl glycerophosphocholine of plasma lipoproteins during incubation with group V and X secretory phospholipase A2s Lipids (IF 1.9) Pub Date : 2021-12-13 Arnis Kuksis, Waldemar Pruzanski
Plasma lipoproteins are carriers of various glycerophospholipids including diacyl, alkenyl/acyl, and alkyl/acyl glycerophosphocholines (GPCs), which become distributed among cells and tissues during metabolism. For metabolic function, these phospholipids require hydrolysis by phospholipases, but the responsible enzymes have not been identified. We had previously shown that after complete digestion
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Lipopolysaccharide and tyloxapol accelerate the development of atherosclerosis in mice Lipids (IF 1.9) Pub Date : 2021-12-07 Meiyu Jin, Di Zhang, Lianwen Zheng, Yunfei Wei, Siru Yan, Haiyan Qin, Qi Wang, Lilei Zhao, Haihua Feng
The occurrence of atherosclerosis is closely related to inflammation and lipid metabolism disorder. It has been found that lipopolysaccharide (LPS) could induce inflammation, and tyloxapol (Ty) could induce hyperlipidemia. However, the effects of LPS and Ty on the development and mechanism of atherosclerosis have not been investigated thoroughly. To answer this question, we used assay kits to detect
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Both full length-cholesteryl ester transfer protein and exon 9-deleted cholesteryl ester transfer protein promote triacylglycerol storage in cultured hepatocytes Lipids (IF 1.9) Pub Date : 2021-12-05 Yan Liu, Daniel Mihna, Lahoucine Izem, Richard E. Morton
We previously reported that overexpression of full-length cholesteryl ester transfer protein (FL-CETP), but not its exon 9-deleted variant (∆E9-CETP), in an adipose cell line reduces their triacylglycerol (TAG) content. This provided mechanistic insight into several in vivo studies where FL-CETP levels are inversely correlated with adiposity. However, increased FL-CETP is also associated with elevated
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Comparison of Ahiflower oil containing stearidonic acid to a high-alpha-linolenic acid flaxseed oil at two levels on tissue omega-3 enrichment in broilers Lipids (IF 1.9) Pub Date : 2021-11-20 Ahmed S. A. El-Zenary, Khalid M. Gaafar, Reham Abou-Elkhair, Robert G. Elkin, John W. Boney, Kevin J. Harvatine
Enrichment of broiler meat with very long-chain omega-3 fatty acids (VLCn-3 FA) is of interest because of their beneficial effects on human health. The ability of Ahiflower® (AHI) oil (Buglossoides arvensis), which naturally contains stearidonic acid (SDA), and a high-alpha-linolenic acid (ALA) flaxseed (FLAX) oil to enrich VLCn-3 FA contents in broilers tissues was investigated. Fifty-five Cobb 500
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Trans-10 18:1 in ruminant meats: A review Lipids (IF 1.9) Pub Date : 2021-10-04 Susana P. Alves, Payam Vahmani, Cletos Mapiye, Tim A. McAllister, Rui J. B. Bessa, Michael E. R. Dugan
Trans (t) fatty acids (TFA) from partially hydrogenated vegetable oils (i.e., industrial trans) have been phased out of foods in many countries due to their promotion of cardiovascular disease. This leaves ruminant-derived foods as the main source of TFA. Unlike industrial TFA where catalytic hydrogenation yields a broad distribution of isomers, ruminant TFA are enzymatically derived and can result
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2-Arachidonoyl glycerol potently induces cholecystokinin secretion in murine enteroendocrine STC-1 cells via cannabinoid receptor CB1 Lipids (IF 1.9) Pub Date : 2021-09-17 Keita Ochiai, Rina Hirooka, Masayoshi Sakaino, Shigeo Takeuchi, Tohru Hira
Cholecystokinin (CCK) is a peptide hormone secreted from enteroendocrine cells and regulates the exocrine pancreas, gastric motility, and appetite. Dietary triacylglycerols are hydrolyzed to fatty acids (FA) and 2-monoacylglycerols (2-MAG) in the small intestine. Although it is well known that FA stimulate CCK secretion, whether 2-MAG have the CCK-releasing activity remains unclear. We examined the
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Neuroprotective activity of new Δ3-N-acylethanolamines in a focal ischemia stroke model Lipids (IF 1.9) Pub Date : 2021-11-09 Rahau S. Shirazi, Mikhail Vyssotski, Kirill Lagutin, Dion Thompson, Christa MacDonald, Vincent Luscombe, Michelle Glass, Kim Parker, Emma K. Gowing, D. Bradley G. Williams, Andrew N. Clarkson
N-acylethanolamines (NAE, also called ethanolamides) are significant lipid signaling molecules with anti-inflammatory, pain-relieving, cell-protective, and anticancer properties. Here, we present the use of a hitherto unreported group of Δ3-NAE and also some Δ4- and Δ5-NAE, in in vitro and in vivo assays to gain a better understanding of their structure–bioactivity relationships. We have developed
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Jacaranda oil administration improves serum biomarkers and bioavailability of bioactive conjugated fatty acids, and alters fatty acid profile of mice tissues Lipids (IF 1.9) Pub Date : 2021-11-05 Carina P. Van Nieuwenhove, Andrea del Huerto Moyano, Guido A. Van Nieuwenhove, Verónica Molina, Patricia Luna Pizarro
Jacaric acid, a conjugated linolenic acid (CLNA) present in jacaranda oil (JO), is considered a potent anticarcinogenic agent. Several studies have focused on its biological effects, but the metabolism once consumed is not clear yet. The aim of this work was to evaluate the effects of two different daily doses of JO on serum parameters and fatty acid (FA) profile of mice tissues after 4 weeks of feeding
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Astragalus polysaccharide regulates brown adipocytes differentiation by miR-6911 targeting Prdm16 Lipids (IF 1.9) Pub Date : 2021-11-05 Shihe Zhang, Pengkang Song, Xiaoyou Chen, Yu Wang, Xuyang Gao, Lin Liang, Junxing Zhao
Brown adipose tissue (BAT) is a specialized tissue in mammals related to thermogenesis. The Astragalus polysaccharide (APS) is the major natural active component of Astragalus membranaceus, which has been recognized as one of the most popular herbal medicines worldwide. The role and possible mechanisms of APS on brown adipocytes differentiation is not well defined. Here, we explored the effect of APS