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Quercetin attenuates cisplatin-induced mitochondrial apoptosis via PI3K/Akt mediated inhibition of oxidative stress in pericytes and improves the blood labyrinth barrier permeability Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-13 Tian-Lan Huang, Wen-Jun Jiang, Zan Zhou, Tian-Feng Shi, Miao Yu, Meng Yu, Jun-Qiang Si, Yan-Ping Wang, Li Li
Cisplatin (CDDP) is broadly employed to treat different cancers, whereas there are no drugs approved by the Food and Drug Administration (FDA) for preventing its side effects, including ototoxicity. Quercetin (QU) is a widely available natural flavonoid compound with anti-tumor and antioxidant properties. The research was designed to explore the protective effects of QU on CDDP-induced ototoxicity
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Aldo-keto reductase-7A2 protects against atorvastatin-induced hepatotoxicity via Nrf2 activation Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-12 Dan Li, Jiajin Chen, Fei Zhou, Wenhe Zhang, Hongyu Chen
Atorvastatin (ATO), as a cholesterol-lowering drug, was the world's best-selling drug in the early 2000s. However, ATO overdose-induced liver or muscle injury is a threat to many patients, which restricts its application. Previous studies suggest that ATO overdose is accompanied with ROS accumulation and increased lipid peroxidation, which are the leading causes of ATO-induced liver damage. This study
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Toxicity of minoxidil – Comprehensive in silico prediction of main toxicity endpoints: Acute toxicity, irritation of skin and eye, genetic toxicity, health effect, cardiotoxicity and endocrine system disruption Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-12 Adrian Frydrych, Kamil Jurowski
This article focusses on elucidating the toxicological profile of minoxidil, a widely used pharmacological agent for alopecia, through the application of methods (Percepta ACD/Labs software). This research is driven by the need to understand key toxicological endpoints: acute toxicity, skin and eye irritation, genetic toxicity, cardiotoxicity, disruption of the endocrine system, and estimation of various
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Rosamultin ameliorates radiation injury via promoting DNA injury repair and suppressing oxidative stress in vitro and in vivo Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-12 Ning Liu, Mengxin Niu, Saiyan Luo, Lijuan Lv, Xiaoxiao Quan, Chang Wang, Zhiyun Meng, Jingquan Yuan, Qiongming Xu, Yanli Liu
Radiotherapy remains the preferred treatment option for cancer patients with the advantages of broad indications and significant therapeutic effects. However, ionizing radiation can also damage normal tissues. Unfortunately, there are few anti-radiation damage drugs available on the market for radiotherapy patients. Our previous study showed that rosamultin had antioxidant and hepatoprotective activities
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The mechanism of anthracene degradation by tryptophan −2,3-dioxygenase (T23D) in Comamonas testosterone Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-11 Miao Xu, Xiao Yang, Jinyuan Zhang, Dong Liu, Chuanzhi Zhang, Ming Wu, Elshan Musazade, Edmund Maser, Guangming Xiong, Liquan Guo
It is well known that anthracene is a persistent organic pollutant. Among the four natural polycyclic aromatic hydrocarbons (PAHs) degrading strains, (CT1) was selected as the strain with the highest degradation efficiency. In the present study, prokaryotic transcriptome analysis of CT1 revealed an increase in a gene that encodes tryptophane-2,3-dioxygenase (T23D) in the anthracene and erythromycin
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New Ca2+ based anticancer nanomaterials trigger multiple cell death targeting Ca2+ homeostasis for cancer therapy Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-11 Junjie Liu, Yimin Xie, Jun Ma, Hezhen Chu
Calcium ion (Ca) is a necessary element for human and Ca homeostasis plays important roles in various cellular process and functions. Recent reaches have targeted on inducing Ca overload (both intracellular and transcellular) for tumor therapy. With the development of nanotechnology, nanoplatform-mediated Ca overload has been safe theranostic model for cancer therapy, and defined a special calcium
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Design, synthesis and mechanism study of coumarin-sulfonamide derivatives as carbonic anhydrase IX inhibitors with anticancer activity Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-11 Qianqian Lv, Jing Zhang, Jianghong Cai, Lexian Chen, Jiajie Liang, Tianwan Zhang, Jiahui Lin, Ruiyao Chen, Zhiling Zhang, Peiting Guo, Yue Hong, Lingxue Pan, Hong Ji
In this study, twenty-nine coumarin-3-sulfonamide derivatives, twenty-seven of which are original were designed and synthesized. Cytotoxicity assay indicated that most of these derivatives exhibited moderated to good potency against A549 cells. Among them, compound showed potent inhibition against the four tested cancer cell lines, especially A549 cells with IC value of 6.01 ± 0.81 μM, and much lower
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A systematic review on understanding the mechanistic pathways and clinical aspects of natural CDK inhibitors on cancer progression.: Unlocking cellular and biochemical mechanisms Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-11 Andleeb Asghar, Tahir Ali Chohan, Umair Khurshid, Hammad Saleem, Mian Waqar Mustafa, Anjum Khursheed, Ahmed Alafnan, Rahila Batul, Mohammed Khaled Bin Break, Khaled Almansour, Sirajudheen Anwar
Cell division, differentiation, and controlled cell death are all regulated by phosphorylation, a key biological function. This mechanism is controlled by a variety of enzymes, with cyclin-dependent kinases (CDKs) being particularly important in phosphorylating proteins at serine and threonine sites. CDKs, which contain 20 unique components, serve an important role in regulating vital physiological
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Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1–NF-κB–p65 signaling pathway Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-11 Yitong Yang, Nisha Wang, Zhenyi Wang, Miaomiao Zhao, Luping Chen, Zhaoling Shi
Kawasaki disease (KD), an acute exanthematous febrile pediatric illness involving systemic non-specific inflammatory reactions in small- and medium-sized arteries, poses a significant risk of coronary artery and myocardial inflammatory injury. Developing new KD treatments with improved safety and fewer side-effects is highly desirable. Forsythoside B (FTS-B), extracted from the plant, exerts anti-inflammatory
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The copper transporter, SLC31A1, transcriptionally activated by ELF3, imbalances copper homeostasis to exacerbate cisplatin-induced acute kidney injury through mitochondrial dysfunction Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-09 Zhimin Qiu, Qicen Liu, Ling Wang, Yingfen Xiong, Juan Wu, Meijian Wang, Xiluan Yan, Huangying Deng
Acute kidney injury (AKI) is a common complication of cisplatin chemotherapy, which greatly limits its clinical effect and application. This study explored the function of solute Carrier Family 31 Member 1 (SLC31A1) in cisplatin-induced AKI and its possible mechanism. Mice and HK-2 cells were exposed to cisplatin to establish the and AKI models. Cell viability was detected by CCK-8. Mitochondrial and
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Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-07 Barbara Łasut-Szyszka, Agnieszka Gdowicz-Kłosok, Beata Małachowska, Małgorzata Krześniak, Agnieszka Będzińska, Marta Gawin, Monika Pietrowska, Marek Rusin
Transcriptomic analyses have revealed hundreds of p53-regulated genes; however, these studies used a limited number of cell lines and p53-activating agents. Therefore, we searched for candidate p53-target genes by employing stress factors and cell lines never before used in a high-throughput search for p53-regulated genes. We performed RNA-Seq on A549 cells exposed to camptothecin, actinomycin D, nutlin-3a
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Assessments of carbon nanotubes toxicities in zebrafish larvae using multiple physiological and molecular endpoints Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-05 Gilbert Audira, Jiann-Shing Lee, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao
In recent years, carbon nanotubes (CNTs) have become one of the most promising materials for the technology industry. However, due to the extensive usage of these materials, they may be released into the environment, and cause toxicities to the organism. Here, their acute toxicities in zebrafish embryos and larvae were evaluated by using various assessments that may provide us with a novel perspective
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Taurine induces hormesis in multiple biological models: May have transformative implications for overall societal health Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-01 Edward J. Calabrese, Peter Pressman, A. Wallace Hayes, Rachna Kapoor, Gaurav Dhawan, Evgenios Agathokleous, Vittorio Calabrese
This paper represents the first integrative assessment and documentation of taurine-induced hormetic effects in the biological and biomedical areas, their dose response features, mechanistic frameworks, and possible public health, therapeutic and commercial applications. Taurine-induced hormetic effects are documented in a wide range of experimental models, cell types and for numerous biological endpoints
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Icaritin activates p53 and inhibits aerobic glycolysis in liver cancer cells Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-03-01 Xiangyang Zhou, Di Wu, Tian Mi, Ruohan Li, Tao Guo, Wenjuan Li
Metabolic reprogramming enables cancer cells to generate energy mainly through aerobic glycolysis, which is achieved by increasing the expression levels of glycolysis-related enzymes. Therefore, the development of drugs targeting aerobic glycolysis could be an effective strategy for cancer treatment. Icaritin (ICT) is an active ingredient from the Chinese herbal plant with several biological activities
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Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-28 Cheok Wui Chee, Najihah Mohd Hashim, Nurshamimi Nor Rashid
There is an increasing demand for anticancer agent in treating colorectal cancer (CRC) with frequently mutated and genes. Phytochemical compounds are suitable as chemoprevention for CRC since dietary factor is a major risk factor. Anthraquinones from L. were previously reported with various pharmacological properties. Various experiments were conducted to investigate the effects of two anthraquinones:
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No-observed-adverse-effect-level (NOAEL) assessment as an optimized dose of cholinesterase reactivators for the treatment of exposure to warfare nerve agents in mice Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-28 Marilène Trancart, Anne-Sophie Hanak, Chloé Dambrune, Méliati Madi, Camille Voros, Rachid Baati, André-Guilhem Calas
Despite the international convention on the prohibition of chemical weapons ratified in 1997, the threat of conflicts and terrorist attacks involving such weapons still exists. Among these, organophosphorus-nerve agents (OPs) inhibit cholinesterases (ChE) causing cholinergic syndrome. The reactivation of these enzymes is therefore essential to protect the poisoned people. However, these reactivating
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Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-26 Boxin Yang, Junxiong Wang, Jiao Qiao, Qian Zhang, Qi Liu, Yuan Tan, Qingchen Wang, Wenyuan Sun, Weimin Feng, Zhongxin Li, Chong Wang, Shuo Yang, Liyan Cui
Acute kidney injury (AKI) is a disease characterised by acute onset, high mortality, and poor prognosis, and is mainly caused by ischemia-reperfusion (I/R). Human urine-derived stem cells (USCs) exhibit antioxidant, anti-inflammatory, and anti-apoptotic cytoprotective effects. Previously, we found that exosomes from USCs had the ability to inhibit apoptosis and protect kidneys from I/R injury. This
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Evaluating flavonoids as potential aromatase inhibitors for breast cancer treatment: In vitro studies and in silico predictions Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-24 Jeong In Seo, Jun Sang Yu, Yonghui Zhang, Hye Hyun Yoo
Aromatase inhibitors are commonly employed in the treatment of hormone-dependent breast cancers, and flavonoids have emerged as a promising alternative to existing drug classes with unfavorable side effects. In this study, we conducted investigations into CYP19A1 (aromatase) inhibitory potential of 14 flavonoids, including pinocembrin, sakuranetin, eriodictyol, liquiritigenin, naringenin, hesperetin
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Effects of myricetin and quercetin on ticagrelor metabolism and the underlying mechanism Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-23 Jing Wang, Yingying Hu, Qingqing Li, Ya-nan Liu, Jingjing Lin, Ren-ai Xu
The aim of this study was to investigate the potential drug-drug interactions (DDIs) between ticagrelor and other drugs as well as their underlying mechanisms. Rat liver microsome (RLM) reaction system was used to screen potential DDIs , and ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was applied to detect the levels of ticagrelor and AR-C124910XX, the main metabolite
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SIRT6 activates PPARα to improve doxorubicin-induced myocardial cell aging and damage Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-22 Shulin Wang, Xuan Zhang, Yanhong Hou, Yuliang Zhang, Jiamin Chen, Shuhan Gao, Huiying Duan, Shaoju Gu, Shanshan Yu, Yi Cai
The Sirtuins family, formally known as the Silent Information Regulator Factors, constitutes a highly conserved group of histone deacetylases. Recent studies have illuminated SIRT6's role in doxorubicin (DOX)-induced oxidative stress and apoptosis within myocardial cells. Nevertheless, the extent of SIRT6's impact on DOX-triggered myocardial cell aging and damage remains uncertain, with the associated
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Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: Mechanisms insights and efficiencies Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-21 Tarik Aanniz, Abdelhakim Bouyahya, Abdelaali Balahbib, Kawtar El Kadri, Asaad Khalid, Hafiz A. Makeen, Hassan A. Alhazmi, Nasreddine El Omari, Younes Zaid, Rebecca Shin-Yee Wong, Chien Ing Yeo, Bey Hing Goh, Saad Bakrim
The regulation of gene expression is fundamental to health and life and is essentially carried out at the promoter region of the DNA of each gene. Depending on the molecular context, this region may be accessible or non-accessible (possibility of integration of RNA polymerase or not at this region). Among enzymes that control this process, DNA methyltransferase enzymes (DNMTs), are responsible for
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Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-19 Jana Kasparkova, Vojtech Novohradsky, José Ruiz, Viktor Brabec
Cyclometalated Ir(III) complex [Ir(L) (dppz)]PF (where L = 1-methyl-2-(thiophen-2-yl)-1H-benzo []imidazole and dppz = dipyrido [3,2-:2′,3′-]phenazine) () is potent anticancer agent whose potency can be significantly increased by irradiation with blue light. Structural features of the cyclometalated Ir(III) complex investigated in this work, particularly the presence of dppz ligand possessing an extended
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Human CYP1A1-activated aneugenicity of aflatoxin B1 in mammalian cells and its combined effect with benzo(a)pyrene Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-19 Huanhuan Wang, Qin Fan, Qian Liang, Yao Wu, Zhongming Ye, Haipeng Wu, Qian Sun, Huanwen Tang, Yungang Liu, Qizhan Liu, Yuting Chen
Aflatoxin B1 (AFB1) is the most toxic mycotoxin and a proven human carcinogen that requires metabolic activation, known by cytochrome P450 (CYP) 1A2 and 3A4. Previous evidence showed that AFB1 is activated by human recombinant CYP1A1 expressed in budding yeast. Yet, the toxicity, in particular the genotoxicity of the reactive metabolites formed from AFB1 remains unclear. Humans could be exposed to
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High incidence of sebaceous gland inflammation in aldose reductase-deficient mice Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-17 Anjali Mandava, Binhan Pham, Michelle Pedler, Biehuoy Shieh, Hari Gopalakrishnan, J. Mark Petrash
Aldose reductase is a member of the 1B1 subfamily of aldo-keto reductase gene superfamily. The action of aldose reductase (AR) has been implicated in the pathogenesis of a variety of disease states, most notably complications of diabetes mellitus including neuropathy, retinopathy, nephropathy, and cataracts. To explore for mechanistic roles for AR in disease pathogenesis, we established mutant strains
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Neurotoxicity of Pyrethroids in neurodegenerative diseases: From animals' models to humans’ studies Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-15 Rafael Arsuffi-Marcon, Lizandra Gomes Souza, Artur Santos-Miranda, Julliane V. Joviano-Santos
Neurodegenerative diseases are associated with diverse symptoms, both motor and mental. Genetic and environmental factors can trigger neurodegenerative diseases. Chemicals as pesticides are constantly used in agriculture and also domestically. In this regard, pyrethroids (PY), are a class of insecticides in which its main mechanism of action is through disruption of voltage-dependent sodium channels
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Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-15 Elena Navarro-Carrasco, Aurora Campos-Díaz, Eva Monte-Serrano, Frank Rolfs, Richard de Goeij-de Haas, Thang V. Pham, Sander R. Piersma, Connie R. Jiménez, Pedro A. Lazo
Dynamic chromatin remodeling requires regulatory mechanisms for its adaptation to different nuclear function, which are likely to be mediated by signaling proteins. In this context, VRK1 is a nuclear Ser-Thr kinase that regulates pathways associated with transcription, replication, recombination, and DNA repair. Therefore, VRK1 is a potential regulatory, or coordinator, molecule in these processes
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Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-15 Cyrus Takahashi, Mikhail Chtcherbinine, Brandt C. Huddle, Michael W. Wilson, Timothy Emmel, Robert M. Hohlman, Stacy McGonigal, Ronald J. Buckanovich, Scott D. Larsen, Thomas D. Hurley
Aldehyde dehydrogenase 1A (ALDH1A) isoforms may be a useful target for overcoming chemotherapy resistance in high-grade serous ovarian cancer (HGSOC) and other solid tumor cancers. However, as different cancers express different ALDH1A isoforms, isoform selective inhibitors may have a limited therapeutic scope. Furthermore, resistance to an ALDH1A isoform selective inhibitor could arise via induction
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Assessment of anti-hyperglycemic and anti-hyperlipidemic effects of thiazolidine-2,4-dione derivatives in HFD-STZ diabetic animal model Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-15 Saad Fettach, Fatima Zahra Thari, Khalid Karrouchi, Laila Benbacer, Learn-Han Lee, Abdelhakim Bouyahya, Yahia Cherrah, Hassan Sefrioui, Khalid Bougrin, My El Abbes Faouzy
Type 2 diabetes mellitus (T2DM) is a chronic endocrine/metabolic disorder characterized by elevated postprandial and fasting glycemic levels that result in disturbances in primary metabolism. In this study, we evaluated the metabolic effects of thiazolidine-2,4-dione derivatives in Wistar rats and Swiss mice that were fed a high-fat diet (HFD) for 4 weeks and received 90 mg/kg of streptozotocin (STZ)
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Sodium aescinate induces renal toxicity by promoting Nrf2/GPX4-mediated ferroptosis Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-15 Haiyan Zhu, Yenan Duan, Yijing Yang, Enqing Chen, Hanxin Huang, Xi Wang, Jie Zhou
Sodium aescinate (SA) is extracted from seeds and was first marketed as a medicament in German. With the wide application of SA in clinical practice, reports of adverse drug reactions and adverse events have gradually increased, including renal impairment. However, the pathogenic mechanisms of SA have not yet been fully elucidated. The toxic effects and underlying mechanisms of SA were explored in
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Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-13 Wenhui Shen, Xiangchen Zeng, Xianhui Zeng, Baoshan Hu, Chong Ren, Zhiming Lin, Long Zhang, Gang Rui, Miersalijiang Yasen, Xiaohui Chen
Osteosarcoma is a prevalent kind of primary bone malignancy. Trifluoperazine, as an antipsychotic drug, has anti-tumor activity against a variety of cancers. Nevertheless, the impact of trifluoperazine on osteosarcoma is unclear. Our investigation aimed to explore the mechanism of trifluoperazine’s effect on osteosarcoma. We found that trifluoperazine inhibited 143B and U2-OS osteosarcoma cell proliferation
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Thyroid dysfunction caused by exposure to environmental endocrine disruptors and the underlying mechanism: A review Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-08 Jie He, Jie Xu, Mucong Zheng, Kai Pan, Lilin Yang, Lina Ma, Chuyang Wang, Jie Yu
Thyroid disease has been rapidly increasing, but its causes remain unclear. At present, many studies have focused on the relationship between environmental endocrine disruptors (EEDs) and the pathogenesis of thyroid disease. Herein, we summarize such studies exploring the effects of exposure to common EEDs on thyrotoxicosis, finding that EEDs appear to contribute to the pathogenesis of thyroid-related
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Pharmacokinetic interactions between tacrolimus and Wuzhi capsule in liver transplant recipients: Genetic polymorphisms affect the drug interaction Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-08 Siqi Huang, Wei Song, Shuangmiao Jiang, Yuanchen Li, Min Wang, Na Yang, Huaijun Zhu
Wuzhi capsule (WZC), a commonly used Chinese patent medicine to treat various types of liver dysfunction in China, increases the exposure of tacrolimus (TAC) in liver transplant recipients. However, this interaction has inter-individual variability, and the underlying mechanism remains unclear. Current research indicates that CYP3A4/5 and drug transporters influence the disposal of both drugs. This
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Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-07 Liang Kun Huang, Xiao Shuang Zeng, Ze Wen Jiang, Hao Peng, Fei Sun
Steroid-induced osteonecrosis of the femoral head (SONFH), caused by glucocorticoid (GC) administration, is known to exhibit a high incidence worldwide. Although osteoblast apoptosis has been reported as an important cytological basis of SONFH, the precise mechanism remains elusive. Echinacoside (Ech), a natural phenylethanoid glycoside, exerts multiple beneficial effects, such as facilitation of cell
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Role of microsomal metabolism in bromfenac-induced cytotoxicity Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-06 Jang Su Jeon, Hyemin Kim, Seongyea Jo, Jaehoon Sim, Sang Kyum Kim
This study delves into the intricate mechanisms underlying drug-induced liver injury (DILI) with a specific focus on bromfenac, the withdrawn nonsteroidal anti-inflammatory drug. DILI is a pervasive concern in drug development, prompting market withdrawals and posing significant challenges to healthcare. Despite the withdrawal of bromfenac due to DILI, the exact role of its microsomal metabolism in
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Myt1 kinase inhibitors - Insight into structural features, offering potential frameworks Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-06 Katarina Tomović Pavlović, Gordana Kocić, Andrija Šmelcerović
The cell cycle includes two checkpoint arrests allowing to repair of damaged DNA. Many cancer cell lines exhibit weak G1 checkpoint mechanisms relying significantly more on the G2 checkpoint than do healthy cells. Inhibition of Myt1 kinase (PKMYT1), a forgotten member of the Wee family, cyclin-dependent kinase 1 (Cdk1) inhibitory kinase, target for G2 checkpoint abrogation, whose inhibition forces
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Different concentrations of betaxolol switch cell fate between necroptosis, apoptosis, and senescence in human corneal stromal cells Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-05 Jing-Yu Sun, Jun Zhao, Yue Qiu, Ting-Jun Fan
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Change in function and homeostasis of HPA axis: The role of vitamin family Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-05 Xuan Xia, Kaiqi Chen, Yawen Chen
With the improvement of living quality, people pay more and more attention to vitamin supplements. The vitamins in the daily diet can meet the needs of the body. Whether additional vitamin supplementation is necessary still needs to be further explored. Many studies have reported that vitamin deficiency and excessive vitamin supplementation could lead to abnormal development in the body or increase
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Co-treatment with melatonin and ortho-topolin riboside reduces cell viability by altering metabolic profiles in non-small cell lung cancer cells Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-05 Ji Won Lee, Hwanhui Lee, Soon-Wook Noh, Hyung-Kyoon Choi
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Pholiotic acid promotes apoptosis in human metastatic melanoma cells Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-30 R. Avola, A.C.E. Graziano, A. Madrid, M. Clericuzio, V. Cardile, A. Russo
Mushrooms produce a great variety of secondary metabolites that can be successful in both prevention and treatment of various cancers. In particular, higher Basidiomycete mushrooms contain various types of biologically active low-molecular compounds in fruiting bodies with suggested anticarcinogenic effects. The polyamine analogue {(2R)-2-[(S)-3-hydroxy-3-methylglutaryloxy] putrescine dicinnamamide}
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Layered double hydroxides (LDHs) as efficient and safe carriers for miRNA inhibitors: In vitro and in vivo assessment of biocompatibility Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-02 Mykaella Andrade de Araújo, Erivaldo Davi dos Santos Júnior, Bruna Priscila dos Santos, Ygor Daniel Ramos dos Santos, Pedro Augusto Tibúrcio Paulino, Elane Conceição dos Santos, Tayhana Priscila Medeiros Souza, Lucas Anhezini, Ênio José Bassi, Marcelo Duzzioni, Olagide Wagner de Castro, Tiago Gomes de Andrade, Camila Braga Dornelas, Daniel Leite Góes Gitaí
Layered double hydroxides (LDHs) have been employed as nano-sized carriers for therapeutic/bio-active molecules, including small interfering RNAs (siRNAs). However, the potential of LDHs nanoparticles for an efficient and safe antisense oligonucleotide (AMO) delivery still requires studies. In this research, we have tested the suitability of a Mg–Al-LDH-based nanocarrier loaded with a miRNA-196b-5p
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Mechanisms of action of mineral fibres in a placental syncytiotrophoblast model: An in vitro toxicology study Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-01 Sonia Fantone, Giovanni Tossetta, Laura Cianfruglia, Andrea Frontini, Tatiana Armeni, Antonio D. Procopio, Armanda Pugnaloni, Alessandro F. Gualtieri, Daniela Marzioni
Asbestos has been widely used due to its unique characteristics. It is known that exposure to asbestos causes serious damage to health but one species, chrysolite, is still used because it is considered less toxic and not biopersistent in some countries. The aim of our study was to investigate if cellular process underlying the proliferation, differentiation and cell death of placental tissues could
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Casticin ameliorates osteoarthritic cartilage damage in rats through PI3K/AKT/HIF-1α signaling Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-02-01 Deren Liu, Wei Mei, Junfeng Kang, Taiyang Liao, Yibao Wei, Lishi Jie, Lei Shi, Peimin Wang, Jun Mao, Peng Wu
Knee osteoarthritis (KOA) is a chronic, disabling knee joint lesion in which degeneration and defects in articular cartilage are the most important features. Casticin (CAS) is a flavonoid extracted from the Chinese herb species that has anti-inflammatory and antitumor effects. The aim of this study was to investigate the therapeutic and mechanistic effects of CAS on cartilage damage in KOA. A KOA rat
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Aldo-keto reductases 7A subfamily: A mini review Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-30 Mengli Zhao, Jiajin Chen, Hongyu Chen, Jingdong Zhang, Dan Li
Aldo-keto reductase-7A (AKR7A) subfamily belongs to the AKR superfamily and is associated with detoxification of aldehydes and ketones by reducing them to the corresponding alcohols. So far five members of ARK7A subfamily are identified: two human members-AKR7A2 and AKR7A3, two rat members-AKR7A1 and AKR7A4, and one mouse member-AKR7A5, which are implicated in several diseases including neurodegenerative
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Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6 Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-24 Xuezhong Wang, Xuyang Li, Jianlin Zhou, Zheng Lei, Xiaoming Yang
Osteoarthritis (OA) is the most common type of arthritis and is an age-related joint disease that is particularly prevalent in subjects over 65 years old. The chronic rise of senescent cells has a close correlation with age-related diseases such as OA, and the senescence-associated secretory phenotype (SASP) is implicated in OA cartilage degeneration pathogenesis. Sirtuin 6 (SIRT6) is likely to be
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PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-28 Dengying Wu, Zhenyu Shen, Yong Gou, Tao Yu, Jiaqian Hong, Yitong Wang, Feifei Ni, Naren qiqige, Hongwei Lu, Enxing Xue
Osteoarthritis (OA) is a progressive age-related disease characterised by pathological changes in the synovium, articular cartilage, and subchondral bone, significantly reducing the patients' quality of life. This study investigated the role of glucocorticoids, specifically dexamethasone, in OA progression, with a particular focus on their effects on chondrocytes. Although glucocorticoids are commonly
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Pharmacokinetic interactions of niclosamide in rats: Involvement of organic anion transporters 1 and 3 and organic cation transporter 2 Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-25 Min-Ji Kang, Min Ju Kim, Aeran Kim, Tae-Sung Koo, Kyeong-Ryoon Lee, Yoon-Jee Chae
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f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-24 Tuo Liu, Lili Yang, Zeng Li, Ming Sun, Na Lv
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DIA proteomics analysis reveals the mechanism of folic acid-induced acute kidney injury and the effects of icariin Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-24 Denglu Zhang, Shuai Liu, Huihui Jiang, Shuangde Liu, Feng Kong
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Mitigation of lens opacification by a functional food in a diabetic rodent model Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-23 Krishna K. Kalahasti, Ch Uday Kumar, Marka Nagaraju, J. Mark Petrash, S. Sreenivasa Reddy, G. Bhanuprakash Reddy
The current study was designed to test a functional food (FF) mixture containing aldose reductase inhibitors and antiglycation bioactive compounds for suppressing the onset and progression of cataracts in a diabetic rat model. Two-month-old Sprague Dawley rats were grouped as control (C), diabetes untreated (D), and diabetic rats treated with FF at two doses (FF1 = 1.35 g and FF2 = 6.25 g/100g of diet)
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Computational analysis of human medium-chain dehydrogenases/reductases revealing substrate- and coenzyme-binding characteristics Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-22 Linus J. Östberg, Jan-Olov Höög, Bengt Persson
The medium-chain dehydrogenase/reductase (MDR) superfamily has more than 600,000 members in UniProt as of March 2023. As the family has been growing, the proportion of functionally characterized proteins has been falling behind. The aim of this project was to investigate the binding pockets of nine different MDR protein families based on sequence conservation patterns and three-dimensional structures
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Mitochondrial reactive oxygen species initiate gasdermin D-mediated pyroptosis and contribute to paraquat-induced nephrotoxicity Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-17 Kaiyuan Chen, Mengxuan Li, Yahui Tang, Zhongqiu Lu
Paraquat (PQ)-induced acute kidney injury (AKI) progresses rapidly and is associated with high mortality rates; however, no specific antidote for PQ has been identified. Poor understanding of toxicological mechanisms underlying PQ has hindered the development of suitable treatments to combat PQ exposure. Gasdermin D (GSDMD), a key executor of pyroptosis, has recently been shown to enhance nephrotoxicity
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Piperlongumine inhibits esophageal squamous cell carcinoma in vitro and in vivo by triggering NRF2/ROS/TXNIP/NLRP3-dependent pyroptosis Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-18 Yue Cui, Xiao-bo Chen, Ying Liu, Qian Wang, Jie Tang, Man-jun Chen
Pyroptosis, a type of programmed cell death, is characterized by cell swelling with bubbles, and the release of inflammatory cell cytokines. Piperlongumine (PL) is a natural bioactive product extracted from Piper longum L, which can effectively exert anti-tumor activities in cancer. However, the effects and the exact molecular mechanisms of PL in esophageal squamous cell carcinoma (ESCC) remain unclear
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The marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol prevents TNF-α-mediated impairment of mineralization in mouse osteoblastic MC3T3-E1 cells: Impact of macrophage activation Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-14 Masayoshi Yamaguchi, Kenji Yoshiike, Hideaki Watanabe, Mitsugu Watanabe
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Light-switchable diazocines as potential inhibitors of testosterone-synthesizing 17β-hydroxysteroid dehydrogenase 3 Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-18 F. Wages, T. Brandt, H.-J. Martin, R. Herges, E. Maser
In patients with prostate carcinoma as well as in some other cancer types, the reduction of testosterone levels is desired because the hormone stimulates cancer cell growth. One molecular target for this goal is the inhibition of 17β-hydroxysteroid dehydrogenase type 3 (17βHSD3), which produces testosterone from its direct precursor androstenedione. Recent research in this field is trying to harness
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GW4064 inhibits migration and invasion through cathepsin B and MMP2 downregulation in human bladder cancer Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-10 Chien-Chang Kao, Chien-Rui Lai, Yi-Hsuan Lin, Tzu-Min Chen, Yu-Ling Tsai, Wen-Chiuan Tsai, Tze-Yun Ong, Hisao-Hsien Wang, Sheng-Tang Wu, Ying Chen
The ability of bladder cancer to invade and metastasize often leads to poor prognosis in bladder cancer patients. The aim of this study was to evaluate the effect of the farnesoid X receptor (FXR) agonist GW4064 on the migration and invasion of human bladder cancer cells. Long-term exposure to GW4064 decreased the colony formation of RT4 and T24 cells. The wound healing migration assay revealed an
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β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-11 Lei Zhao, Hui Miao, Mingqi Quan, Shuhao Wang, Yu Zhang, Houkun Zhou, Xianglan Zhang, Zhenhua Lin, Junjie Piao
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Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis Chem. Biol. Interact. (IF 5.1) Pub Date : 2024-01-12 Siyuan Li, Xiaomei Xue, Hui Zhang, Lai Jiang, Yunqian Zhang, Xiaoyan Zhu, Yan Wang
Acute lung injury (ALI) is a frequent complication of sepsis, with pyroptosis playing a pivotal role. Analysis of Gene Expression Omnibus (GEO) mouse sepsis datasets revealed the upregulation of sphingosine kinase 1 (SphK1) in septic mouse lung tissues, which was validated in lipopolysaccharide (LPS)-treated mice. Therefore, this study aimed to explore the potential role and underlying mechanisms of