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Diacylglycerol Kinase η Activity in Cells Using Protein Myristoylation and Cellular Phosphatidic Acid Sensor Lipids (IF 1.919) Pub Date : 2021-02-24 Ayuka Ishizaki; Chiaki Murakami; Haruka Yamada; Fumio Sakane
Diacylglycerol kinase (DGK) phosphorylates diacylglycerol to produce phosphatidic acid (PtdOH) and regulates the balance between two lipid second messengers: diacylglycerol and PtdOH. Several lines of evidence suggest that the η isozyme of DGK is involved in the pathogenesis of bipolar disorder. However, the detailed molecular mechanisms regulating the pathophysiological functions remain unclear. One
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Comparison of the Effects of Statins on A549 Nonsmall‐Cell Lung Cancer Cell Line Lipids Using Fourier Transform Infrared Spectroscopy: Rosuvastatin Stands Out Lipids (IF 1.919) Pub Date : 2021-02-21 Hatice Nurdan Aksoy; Cagatay Ceylan
Statins are commonly prescribed antilipidemic and anticholesterol class of drugs. In addition to their major role, they have been found to have anticancer effects on in vitro, animal and clinical studies. The aim of this study was to investigate the effects of six different statins (rosuvastatin, pravastatin, simvastatin, lovastatin, fluvastatin, and atorvastatin) on A549 cancer cells lipids by Fourier
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Assessment of the effects of sex and harvesting season on lipid and fatty acid composition of Sparidae species Lipids (IF 1.919) Pub Date : 2021-02-20 Cansu Metin; Yunus Alparslan; Hatice H. Yapıcı; Zerrin Ekşi; Taçnur Baygar
In the present study, the lipid amount and fatty acid profile of different Sparidae species, including gilthead seabream, juvenile gilthead seabream, annular seabream, white seabream, common two‐banded seabream were evaluated. Fish were seasonally collected from Köyceğiz Lagoon (Muğla, South Western Turkey) from June 2018 to June 2019 and after collection, the sex of each specimen was recorded. According
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Consumption of High‐Oleic Soybean Oil Improves Lipid and Lipoprotein Profile in Humans Compared to a Palm Oil Blend: A Randomized Controlled Trial Lipids (IF 1.919) Pub Date : 2021-02-17 David J. Baer; Theresa Henderson; Sarah K. Gebauer
Partially hydrogenated oils (PHO) have been removed from the food supply due to adverse effects on risk for coronary heart disease (CHD). High‐oleic soybean oils (HOSBO) are alternatives that provide functionality for different food applications. The objective of this study was to determine how consumption of diets containing HOSBO compared to other alternative oils, with similar functional properties
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Production of C6–C14 Medium‐Chain Fatty Acids in Seeds and Leaves via Overexpression of Single Hotdog‐Fold Acyl‐Lipid Thioesterases Lipids (IF 1.919) Pub Date : 2021-02-06 Rebecca S. Kalinger; Danielle Williams; Ali Ahmadi Pirshahid; Ian P. Pulsifer; Owen Rowland
ACYL‐LIPID THIOESTERASES (ALT) are a type of plant acyl–acyl carrier protein thioesterase that generate a wide range of medium‐chain fatty acids and methylketone (MK) precursors when expressed heterologously in Escherichia coli. While this makes ALT‐type thioesterases attractive as metabolic engineering targets to increase production of high‐value medium‐chain fatty acids and MKs in plant systems,
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Borage Oil Enhances Lamellar Body Content and Alters Fatty Acid Composition of Epidermal Ceramides in Essential Fatty Acid‐Deficient Guinea Pigs Lipids (IF 1.919) Pub Date : 2020-12-30 Kun‐Pyo Kim; Kyong‐Oh Shin; Kyungho Park; Yunhi Cho
Borage oil [BO: 40.9% linoleic acid (LNA) and 24.0% γ‐linolenic acid (GLA)] reverses disrupted epidermal lipid barrier in essential fatty acid deficiency (EFAD). We determined the effects of BO on lamellar body (LB) content and LNA and GLA incorporation into epidermal ceramide 1 (CER1) and epidermal ceramide 2 (CER2), major barrier lipids. EFAD was induced in guinea pigs by a diet of 6% hydrogenated
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Naked Mole‐Rat, a Rodent with an Apolipoprotein A‐I Dimer Lipids (IF 1.919) Pub Date : 2020-12-17 Don L. Puppione; Denise P. Tran; Muhammad A. Zenaidee; Sarada Charugundla; Julian P. Whitelegge; Rochelle Buffenstein
A variety of rodents have been used as experimental animals in metabolic studies of plasma lipids and lipoproteins. These studies have included understanding the functional role of apolipoprotein A‐I, the major protein on the surface of HDL. Reviewing the genomic database for entries for rodent apoA‐I genes, it was discovered that the naked mole‐rat (Heterocephalus glaber) gene encoded a protein with
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miR‐32‐5p Regulates Lipid Accumulation in Intramuscular Fat of Erhualian Pigs by Suppressing KLF3 Lipids (IF 1.919) Pub Date : 2020-12-10 Hongcheng Liu; Wei Wei; Weimin Lin; Wensai Yu; Wu Luo; Yingfang Niu; Lifan Zhang; Jie Chen
Intramuscular fat (IMF) and subcutaneous fat (SCF) are important traits affecting the economics of the pork industry, in which less SCF and more IMF content is desirable. However, the mechanisms that regulate IMF and SCF content are not clear yet. In this study, we demonstrate that KLF3 (Krüppel‐like factor 3) was negatively correlated with IMF content in the longissimus dorsi muscle of Erhualian pigs
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Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes Lipids (IF 1.919) Pub Date : 2020-12-07 Annette L. West; Louise V. Michaelson; Elizabeth A. Miles; Richard P. Haslam; Karen A. Lillycrop; Ramona Georgescu; Lihua Han; Johnathan A. Napier; Philip C. Calder; Graham C. Burdge
The phospholipid composition of lipoproteins is determined by the specificity of hepatic phospholipid biosynthesis. Plasma phospholipid 20:4n‐6 and 22:6n‐3 concentrations are higher in women than in men. We used this sex difference in a lipidomics analysis of the impact of endocrine factors on the phospholipid class and molecular species composition of fasting plasma from young men and women. Diester
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Higher Increase in Plasma DHA in Females Compared to Males Following EPA Supplementation May Be Influenced by a Polymorphism in ELOVL2: An Exploratory Study Lipids (IF 1.919) Pub Date : 2020-11-10 Adam H. Metherel; Maha Irfan; Shannon L. Klingel; David M. Mutch; Richard P. Bazinet
Young adult females have higher blood docosahexaenoic acid (DHA), 22:6n‐3 levels than males, and this is believed to be due to higher DHA synthesis rates, although DHA may also accumulate due to a longer half‐life or a combination of both. However, sex differences in blood fatty acid responses to eicosapentaenoic acid (EPA), 20:5n‐3 or DHA supplementation have not been fully investigated. In this exploratory
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Simple, Rapid Lipidomic Analysis of Triacylglycerols in Bovine Milk by Infusion‐Electrospray Mass Spectrometry Lipids (IF 1.919) Pub Date : 2020-11-09 Michael R. Bukowski; Matthew J. Picklo
Bovine milk is a complex mixture of lipids, proteins, carbohydrates, and other factors of which lipids comprise 3–5% of the total mass. Rapid analysis and characterization of the triacylglycerols (TAG) that comprise about 95% of the total lipid is daunting given the numerous TAG species. In the attached methods paper, we demonstrate an improved method for identifying and quantifying TAG species by
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Network Medicine Approach in Prevention and Personalized Treatment of Dyslipidemias Lipids (IF 1.919) Pub Date : 2020-10-29 Giuditta Benincasa; Paola de Candia; Dario Costa; Mario Faenza; Gelsomina Mansueto; Giuseppe Ambrosio; Claudio Napoli
Dyslipidemias can affect molecular networks underlying the metabolic homeostasis and vascular function leading to atherogenesis at early stages of development. Since disease‐related proteins often interact with each other in functional modules, many advanced network‐oriented algorithms were applied to patient‐derived big data to identify the complex gene–environment interactions underlying the early
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The Potential of Genome Editing for Improving Seed Oil Content and Fatty Acid Composition in Oilseed Crops. Lipids (IF 1.919) Pub Date : 2020-08-27 Udaya Subedi,Kethmi N Jayawardhane,Xue Pan,Jocelyn Ozga,Guanqun Chen,Nora A Foroud,Stacy D Singer
A continuous rise in demand for vegetable oils, which comprise mainly the storage lipid triacylglycerol, is fueling a surge in research efforts to increase seed oil content and improve fatty acid composition in oilseed crops. Progress in this area has been achieved using both conventional breeding and transgenic approaches to date. However, further advancements using traditional breeding methods will
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Metabolism of Storage Lipids and the Role of Lipid Droplets in the Yeast Schizosaccharomyces pombe. Lipids (IF 1.919) Pub Date : 2020-09-15 Ivan Hapala,Peter Griac,Roman Holic
Storage lipids, triacylglycerols (TAG), and steryl esters (SE), are predominant constituents of lipid droplets (LD) in fungi. In several yeast species, metabolism of TAG and SE is linked to various cellular processes, including cell division, sporulation, apoptosis, response to stress, and lipotoxicity. In addition, TAG are an important source for the generation of value‐added lipids for industrial
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Role of n‐3 Fatty Acids on Bile Acid Metabolism and Transport in Dyslipidemia: A Review Lipids (IF 1.919) Pub Date : 2020-10-19 Pooja Acharya; Vinayak Uppin; Mehrdad Zarei; Ramaprasad R. Talahalli
Dietary n‐3 fatty acids, especially of marine origin, eicosapentaenoic acid (20:5n‐3) and docosahexaenoic acid (22:6n‐3), have always been lauded for their profound effects on regulating the risk factors for major metabolic disorders. Yet, their consumption rate is poor compared to n‐6 fatty acids [linoleic acid (18:2n‐6)], which are predominantly consumed. Hence, the skewed n‐6 to n‐3 fatty acid ratio
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Hepatic Fatty Acid and Transcriptome Profiles during the Transition from Vegetable‐ to Fish Oil‐Based Diets in Rainbow Trout (Oncorhynchus mykiss) Lipids (IF 1.919) Pub Date : 2020-10-13 Beth M. Cleveland; Guangtu Gao; Lisa M. Radler; Matthew J. Picklo
A finishing diet strategy is effective at increasing fillet long‐chain n‐3 fatty acid content in fish consuming sustainable plant oil‐based diets. This study investigates the outcomes of a fish oil finishing diet upon the hepatic fatty acid and transcriptome profile in rainbow trout (Oncorhynchus mykiss). Fish were placed on one of three feeding treatments: (1) FO: a fish oil (FO) diet for 20 weeks
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The Fatty Acid Composition of Human Follicular Fluid Is Altered by a 6‐Week Dietary Intervention That Includes Marine Omega‐3 Fatty Acids Lipids (IF 1.919) Pub Date : 2020-10-12 Alexandra J. Kermack; Susan J. Wellstead; Helena L. Fisk; Ying Cheong; Franchesca D. Houghton; Nicholas S. Macklon; Philip C. Calder
The fatty acid composition of human follicular fluid is important for oocyte development and for pregnancy following in vitro fertilization (IVF). This study investigated whether a dietary intervention that included an increase in marine omega‐3 fatty acids, olive oil and vitamin D alters the fatty acid composition of human follicular fluid. The association of lifestyle factors with follicular fluid
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Mass Spectrometric Analysis of Sphingomyelin with N‐α‐Hydroxy Fatty Acyl Residue in Mouse Tissues Lipids (IF 1.919) Pub Date : 2020-09-30 Hanif Ali; Ryouhei Yamashita; Jun‐ichi Morishige; Katsuya Morito; Naoya Kakiuchi; Junji Hayashi; Mutsumi Aihara; Ryushi Kawakami; Koichiro Tsuchiya; Tamotsu Tanaka
Sphingomyelin (SM) with N‐α‐hydroxy fatty acyl residues (hSM) has been shown to occur in mammalian skin and digestive epithelia. However, the metabolism and physiological relevance of this characteristic SM species have not been fully elucidated yet. Here, we show methods for mass spectrometric characterization and quantification of hSM. The hSM in mouse skin was isolated by TLC. The hydroxy hexadecanoyl
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Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH‐Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage Lipids (IF 1.919) Pub Date : 2020-09-29 Ephantus Nguma; Yuki Tominaga; Shinji Yamashita; Yurika Otoki; Ayaka Yamamoto; Kiyotaka Nakagawa; Teruo Miyazawa; Mikio Kinoshita
Ethanolamine plasmalogen (PlsEtn), a sub‐class of ethanolamine glycerophospholipids (EtnGpl), is a universal phospholipid in mammalian membranes. Several researchers are interested in the relationship between colon carcinogenesis and colon PlsEtn levels. Here, we evaluated the functional role of dietary purified EtnGpl from the ascidian muscle (87.3 mol% PlsEtn in EtnGpl) and porcine liver (7.2 mol%
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S1P Lyase siRNA Dampens Malignancy of DLD-1 Colorectal Cancer Cells. Lipids (IF 1.919) Pub Date : 2020-09-24 Wajiha Farha Faqar-Uz-Zaman,Katrin G Schmidt,Dominique Thomas,Josef M Pfeilschifter,Heinfried H Radeke,Anja Schwiebs
Sphingosine‐1‐phosphate lyase 1 (S1P lyase or SGPL1) is an essential sphingosine‐1‐phosphate‐degrading enzyme. Its manipulation favors onset and progression of colorectal cancer and others in vivo. Thus, SGPL1 is an important modulator of cancer initiation. However, in established cancer, the impact of retrospective SGPL1 modulation is elusive. Herein, we analyzed how SGPL1 siRNA affects malignancy
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A cross-sectional study on the relationship between homocysteine and lipid profiles among Chinese population from Hunan. Lipids (IF 1.919) Pub Date : 2020-09-21 Xiaona Niu,Jian Chen,Jia Wang,Jing Li,Dan Zeng,Shuling Wang,Xiuqin Hong
Previous studies have explored the relationship between homocystein (Hcy) and lipid profiles. However, the results from these studies have been inconsistent. The current study investigated the correlation between Hcy and lipid profiles in Chinese community‐based population. The participants were composed of 4012 Chinese people aged 30–92 years old, who were recruited from rural and urban communities
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Krill Oil Perturbs Proliferation and Migration of Mouse Colon Cancer Cells in vitro by Impeding Extracellular Signal-Regulated Protein Kinase Signaling Pathway. Lipids (IF 1.919) Pub Date : 2020-09-15 Weiqiang Jing,Yuxuan Bi,Ganyu Wang,Shuyan Zeng,Lihui Han,Hui Yang,Na Wang,Yunxue Zhao
The prevalence of colorectal cancer (CRC) continues to increase. Treatment of CRC remains a significant clinical challenge, and effective therapies for advanced CRC are desperately needed. Increasing attention and ongoing research efforts have focused on krill oil that may provide health benefits to the human body. Here we report that krill oil exerts in vitro anticancer activity through a direct inhibition
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Fat Distribution and Lipid Profile of Young Adults with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Enzyme Deficiency. Lipids (IF 1.919) Pub Date : 2020-09-14 Juliano Henrique Borges,Daniel Minutti de Oliveira,Sofia Helena Valente de Lemos-Marini,Bruno Geloneze,Ezequiel Moreira Gonçalves,Gil Guerra-Júnior
We aimed to compare detailed fat distribution and lipid profile between young adults with congenital adrenal hyperplasia due to 21‐hydroxylase enzyme deficiency and a control group. We also verified independent associations of treatment duration and daily hydrocortisone dose equivalent (HDE) with lipid profile within patients. This case–control study included 23 patients (7 male and 16 female) matched
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The Anionic Phospholipids of Bovine Pulmonary Surfactant. Lipids (IF 1.919) Pub Date : 2020-09-07 Catherine J Markin,Stephen B Hall
The only known compositional change in the phospholipids (PL) of pulmonary surfactant in response to a physiologic stimulus occurs around the time of birth. In most species, the predominant anionic PL changes from phosphatidylinositol (PtdIns) to phosphatidylglycerol (PtdGro). Because prior studies have shown that the change in the headgroup itself is functionally insignificant, we tested the hypothesis
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The Monocyte to High-Density Lipoprotein Cholesterol Ratio in the Prediction for Atherosclerosis: A Retrospective Study in Adult Chinese Participants. Lipids (IF 1.919) Pub Date : 2020-09-07 Yaqing Zhou,Liyi Wang,Limei Jia,Baojin Lu,Guoqiang Gu,Long Bai,Wei Cui
The ratio of monocyte to high‐density lipoprotein cholesterol level (MHR) was a newly proposed inflammatory and oxidative stress marker. This study aimed to explore the association between MHR and Brachial‐ankle pulse wave velocity (Ba‐PWV) in adult Chinese participants. A total of 2029 participants were divided into two groups according to the Ba‐PWV: a high Ba‐PWV group (Ba‐PWV ≥1400 cm/s) and a
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Lipid Composition and Utilization in Early Stage Leptocephalus Larvae of Bonefish (Albula vulpes). Lipids (IF 1.919) Pub Date : 2020-09-04 Sahar Mejri,Aaron J Adams,Jonathan M Shenker,Anthony C Cianciotto,Christopher Robinson,Victoria Uribe,Paul S Wills
In order to encourage the survival of both captive and wild populations of bonefish (Albula vulpes), a deeper understanding of the species' early developmental characteristics is necessary. During ontogenesis, bonefish utilize lipids as a source of energy before the start of exogenous feeding. The goal of this study is to gain insight into the energetic needs of bonefish leptocephalus larvae in the
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Quantification of Fatty Acids and their Regioisomeric Distribution in Triacylglycerols from Porcine and Bovine Sources Using 13 C NMR Spectroscopy. Lipids (IF 1.919) Pub Date : 2020-09-02 Geir Kildahl-Andersen,Eli Gjerlaug-Enger,Frode Rise,Anna Haug,Bjørg Egelandsdal
The uptake of specific fatty acids in humans is dependent on their position on the glycerol backbone. There is a great interest in methods that can access this information fast and accurately. By way of high‐resolution NMR, we have analyzed TAG extracted from pig and beef tissues and obtained quantitative data for the composition and regioisomeric distribution of all major unsaturated fatty acids usually
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Low-Density Lipoprotein Cholesterol/High-Density Lipoprotein Cholesterol Ratio and Carotid Intima-Media Thickness: A Cohort Study in China. Lipids (IF 1.919) Pub Date : 2020-08-28 Pei Qin,Jing Shi,Liming Cao,Xue Li,Yanmei Lou,Changyi Wang,Jianping Ma,Li Wang,Xiaolin Peng,Hongen Chen,Shan Xu,Ping Zhao,Dongsheng Hu,Fulan Hu
Low‐density lipoprotein cholesterol to high‐density lipoprotein cholesterol (LDL‐C/HDL‐C) ratio may carry additional information and has been suggested as a better predictor for atherosclerosis progression and cardiovascular disease (CVD) than LDL‐C and HDL‐C alone. Therefore, we aim to explore the association between LDL‐C/HDL‐C ratio and high carotid intima‐media thickness (CIMT) risk in a large
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Cholesteryl Ester Transfer Protein Impairs Triglyceride Clearance via Androgen Receptor in Male Mice. Lipids (IF 1.919) Pub Date : 2020-08-11 Brian T Palmisano,Uche Anozie,Sophia Yu,Joshua C Neuman,Lin Zhu,Emery M Edington,Thao Luu,John M Stafford
Elevated postprandial triacylglycerols (TAG) are an important risk factor for cardiovascular disease. Men have higher plasma TAG and impaired TAG clearance compared to women, which may contribute to sex differences in risk of cardiovascular disease. Understanding mechanisms of sex differences in TAG metabolism may yield novel therapeutic targets to prevent cardiovascular disease. Cholesteryl ester
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Lipid Composition Differences of Periphyton, Crustaceans, and Small Fishes in Response to Eutrophication and Management in the Florida Everglades, USA. Lipids (IF 1.919) Pub Date : 2020-08-10 Brent J Bellinger,Mark I Cook,Scot E Hagerthey,Susan Newman,Robert M Kobza
Eutrophication of the Florida Everglades, USA, has altered the characteristics of the ecosystem, but management strategies are being implemented to accelerate recovery. In this study, we described lipid compositional similarities and differences between periphyton, fish, and crustaceans, and explored if eutrophication and creation of new open‐water sloughs in phosphorus (P)‐impacted regions of a Northern
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The APOA5-rs662799 Polymorphism Is a Determinant of Dyslipidemia in Vietnamese Primary School Children. Lipids (IF 1.919) Pub Date : 2020-08-10 Nguyen T H Hanh,Bui T Nhung,Le T Hop,Le T Tuyet,Duong T A Dao,Nguyen T T Thu,Tran Quang Binh
Apolipoprotein A‐V encoded by apolipoprotein 5 (APOA5) gene plays an important role in lipid metabolism, especially in the regulation of plasma triglycerol levels. The study aimed to evaluate the association of the APOA5‐rs662799 polymorphism with dyslipidemia in Vietnamese children and the potential modification of obesity‐related traits (body mass index, waist circumference, hip circumference, and
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Lipid Composition of Liposomal Membrane Largely Affects Its Transport and Uptake through Small Intestinal Epithelial Cell Models. Lipids (IF 1.919) Pub Date : 2020-08-08 Keisuke Konishi,Lei Du,Grégory Francius,Michel Linder,Tomoaki Sugawara,Hideyuki Kurihara,Koretaro Takahashi
Lipid composition of liposomal bilayer should alter the cell response for permeability, transport, and uptake in small intestine. This work was done to investigate the transport and uptake of liposomes composed of docosahexaenoic acid‐enriched phosphatidylcholine (PtdCho), phosphatidylserine (PtdSer), and sulfoquinovosyl diacylglycerol (SQDG) derived from marine products on multilamellar vesicles (MLV)
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Diet, Plasma, Erythrocytes, and Spermatozoa Fatty Acid Composition Changes in Young Vegan Men. Lipids (IF 1.919) Pub Date : 2020-08-05 Rodrigo Chamorro,María F Gonzalez,Rocío Aliaga,Valentina Gengler,Constanza Balladares,Cynthia Barrera,Karla A Bascuñan,Richard P Bazinet,Rodrigo Valenzuela
There has been increasing interest in vegan diets, but how this dietary pattern regulates tissue fatty acids (FA), especially in men, is unclear. Our aim was to evaluate the effect of a vegan diet on plasma, erythrocyte, and spermatozoa FA composition in young men. Two groups consisting of 67 young (18–25 years old) men were studied. One group following an omnivore diet but did not consume fish, shellfish
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Distribution of Free and Esterified Oxylipins in Cream, Cell, and Skim Fractions of Human Milk. Lipids (IF 1.919) Pub Date : 2020-07-28 Junai Gan,Zhichao Zhang,Karina Kurudimov,J Bruce German,Ameer Y Taha
Human milk contains oxylipins involved in infant development. Although oxylipins have been identified in whole or skim milk, their localization within human milk cream, cell, and skim fractions is not known. This study determined the distribution of free and esterified oxylipins in cream, cell, and skim fractions of human milk. Out of 72 oxylipins probed by mass‐spectrometry, 42, 29, and 41 oxylipins
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Working with Randy: The Diacylglycerol Acyltransferase Story. Lipids (IF 1.919) Pub Date : 2020-07-23 John L Harwood
Vegetable oils are one of the main agricultural commodities. Demand has been increasing steadily over the last five decades and, with finite land available, it is vital that we increase productivity. My laboratory has focused on the regulation of plant lipid metabolism and, as part of this work, we identified diacylglycerol acyltransferase (DGAT) as important at regulating carbon flux during oil accumulation
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Borage Oil Treated with Immobilized Lipase Inhibits Melanogenesis Lipids (IF 1.919) Pub Date : 2020-07-20 Jin A. Shin; Meixiang Sun; Jong‐Moon Jeong
In the present study, we demonstrated that borage (Borago officinalis L.) seed oil subjected to immobilized lipase pretreatment are enriched with linoleic acid (LNA, 18:2n‐6), γ‐linolenic acid (GLA, 18:3n‐6), and oleic acid (OLA, 18:1n‐9). We further showed that lipase‐treated borage oil (LT‐BOL) regulates the activity and degradation of tyrosinase, an important enzyme implicated in the synthesis of
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Alteration of Serum Phospholipid n-6 Polyunsaturated Fatty Acid Compositions in Nonalcoholic Fatty Liver Disease in the Japanese Population: A Cross-Sectional Study. Lipids (IF 1.919) Pub Date : 2020-07-20 Zhe Jiang,Takuya Hayashi,Kentaro Kashima,Kayo Kurotani,Bungo Shirouchi,Tetsuya Mizoue,Masao Sato
We performed a cross‐sectional study on 215 Japanese employees aged 20–68 years to investigate the association between NAFLD and serum phospholipid fatty acid composition. NAFLD was diagnosed by ultrasonography. The fatty acid composition between the control and NAFLD groups was compared, and the inverse probability of treatment weighting (IPTW) was performed to eliminate each confounding effect of
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Measurement of Enzymatic and Nonenzymatic Polyunsaturated Fatty Acid Oxidation Products in Plasma and Urine of Macular Degeneration Using LC-QTOF-MS/MS. Lipids (IF 1.919) Pub Date : 2020-06-30 Ho Hang Leung,Kin Sum Leung,Thierry Durand,Jean-Marie Galano,Jetty Chung-Yung Lee
Oxidized polyunsaturated fatty acids (PUFA) are associated to pathogenesis of diseases including cardiovascular and neurodegeneration. The novel products are not only biomarkers but also lipid mediators in gene regulation and signaling pathways. Herein, simultaneous quantitation of 28 products derived from nonenzymatic and enzymatic oxidation of PUFA i.e. 5‐, 15‐F2t‐isoprostanes, 7‐, 17‐F2t‐dihomo‐isoprostanes
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Docosahexaenoic Acid Incorporation Is Not Affected by Doxorubicin Chemotherapy in either Whole Cell or Lipid Raft Phospholipids of Breast Cancer Cells in vitro and Tumor Phospholipids in vivo. Lipids (IF 1.919) Pub Date : 2020-06-25 Marnie Newell,Dhruvesh Patel,Susan Goruk,Catherine J Field
To better understand how docosahexaenoic acid (DHA) improves the effects of doxorubicin (DOX), we examined DHA ± DOX on changes in whole cell and lipid raft phospholipids (PL) of MDA‐MB‐231 and MCF‐7 breast cancer cells. We sought to confirm whether the relative changes in PL DHA content of MDA‐MB‐231 cells could be extended to PL from MDA‐MB‐231 tumors grown in mice fed a DHA supplemented diet ±DOX
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Low-Density Lipoproteins, High-Density Lipoproteins (HDL), and HDL-Associated Proteins Differentially Modulate Chronic Myelogenous Leukemia Cell Viability. Lipids (IF 1.919) Pub Date : 2020-06-19 Catherine J Andersen,Lydia Dupree,Kristina Murray,Nicholas Ragonesi,Kaley McMullen,Layra Cintrón-Rivera,Adam Doerr
Cellular lipid metabolism, lipoprotein interactions, and liver X receptor (LXR) activation have been implicated in the pathophysiology and treatment of cancer, although findings vary across cancer models and by lipoprotein profiles. In this study, we investigated the effects of human‐derived low‐density lipoproteins (LDL), high‐density lipoproteins (HDL), and HDL‐associated proteins apolipoprotein
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Association of Dietary Phytosterols with Cardiovascular Disease Biomarkers in Humans. Lipids (IF 1.919) Pub Date : 2020-06-18 Ramandeep Kaur,Semone B Myrie
Cardiovascular disease (CVD) is a leading cause of death worldwide. Elevated concentrations of serum total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) are major lipid biomarkers that contribute to the risk of CVD. Phytosterols well known for their cholesterol‐lowering ability, are non‐nutritive compounds that are naturally found in plant‐based foods and can be classified into plant
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Generation and Characterization of a Soybean Line with a Vernonia galamensis Diacylglycerol Acyltransferase-1 Gene and a myo-Inositol 1-Phosphate Synthase Knockout Mutation. Lipids (IF 1.919) Pub Date : 2020-06-15 Maythem Al-Amery,Ashley Fowler,Jason M Unrine,Paul Armstrong,Elizabeth Maghirang,Kai Su,Julia de Melo,Feng-Jie Yuan,Qing-Yao Shu,David Hildebrand
Soybean (Glycine max) meal is an important protein source. Soybean meal with lower phytate and oligosaccharides improves meal quality. A single recessive mutation in soybean myo‐inositol 1‐phosphate synthase (Gm‐lpa‐TW75‐1) confers a seed phenotype with low phytate and increased inorganic phosphate. The mutant was crossed with high oil lines expressing a diacylglycerol acyltransferase1 (DGAT) gene
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Myelin and Lipid Composition of the Corpus Callosum in Mucopolysaccharidosis Type I Mice. Lipids (IF 1.919) Pub Date : 2020-06-14 Steven Q Le,Igor Nestrasil,Shih-Hsin Kan,Martin Egeland,Jonathan D Cooper,David Elashoff,Rong Guo,Jakub Tolar,Jennifer K Yee,Patricia I Dickson
Mucopolysaccharidosis type I (MPS I) is a lysosomal disease with progressive central nervous system involvement. This study examined the lipid, cholesterol, and myelin basic protein composition of white matter in the corpus callosum of MPS I mice. We studied 50 week‐old, male MPS I mice and littermate, heterozygote controls (n = 12 per group). Male MPS I mice showed lower phosphatidylcholine and ether‐linked
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A Review of Efforts to Improve Lipid Stability during Sample Preparation and Standardization Efforts to Ensure Accuracy in the Reporting of Lipid Measurements. Lipids (IF 1.919) Pub Date : 2020-06-09 Candice Z Ulmer,Jeremy P Koelmel,Christina M Jones,Timothy J Garrett,Juan J Aristizabal-Henao,Hubert W Vesper,John A Bowden
Lipidomics is a rapidly growing field, fueled by developments in analytical instrumentation and bioinformatics. To date, most researchers and industries have employed their own lipidomics workflows without a consensus on best practices. Without a community‐wide consensus on best practices for the prevention of lipid degradation and transformations through sample collection and analysis, it is difficult
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The Fifth WS/DGAT Enzyme of the Bacterium Marinobacter aquaeolei VT8. Lipids (IF 1.919) Pub Date : 2020-05-20 Katharina Vollheyde,Dan Yu,Ellen Hornung,Cornelia Herrfurth,Ivo Feussner
Wax esters (WE) belong to the class of neutral lipids. They are formed by an esterification of a fatty alcohol and an activated fatty acid. Dependent on the chain length and desaturation degree of the fatty acid and the fatty alcohol moiety, WE can have diverse physicochemical properties. WE derived from monounsaturated long‐chain acyl moieties are of industrial interest due to their very good lubrication
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Plasma Ceramides and Triglycerides Are Elevated during Pregnancy in Association with Markers of Insulin Resistance in Hutterite Women. Lipids (IF 1.919) Pub Date : 2020-05-19 Jorge Eduardo Rico,Bonny Specker,Cydne A Perry,Joseph William McFadden
Changes in maternal insulin sensitivity and circulating lipids typically occur during the metabolic transitions of pregnancy and lactation. Although ceramides can cause insulin resistance in mammals, their potential roles during pregnancy and lactation are unknown. We hypothesized that changes in lipids like ceramide and triglycerides could occur across different reproductive states and relate to insulin
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Development of a Novel High-Performance Thin Layer Chromatography-Based Method for the Simultaneous Quantification of Clinically Relevant Lipids from Cells and Tissue Extracts. Lipids (IF 1.919) Pub Date : 2020-05-18 Michelle Pinault,Cyrille Guimaraes,Céline Ben Hassen,Jorge L Gutierrez-Pajares,Stéphan Chevalier,Caroline Goupille,Pierre Bernard-Savary,Philippe G Frank
Lipids such as cholesterol, triacylglycerols, and fatty acids play important roles in the regulation of cellular metabolism and cellular signaling pathways and, as a consequence, in the development of various diseases. It is therefore important to understand how their metabolism is regulated to better define the components involved in the development of various human diseases. In the present work,
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Synergistic Effect of Diacylglycerol and Vitamin D in Ameliorating Dextran Sodium Sulfate-Induced Colitis in Rats. Lipids (IF 1.919) Pub Date : 2020-05-18 Yanan Liu,Baowei Wang,Huixin Xu,Wenhua Ge,Yue Xie,Mingai Zhang,Min Kong,Wenlei Fan
Vitamin D (VD) has the function of antibacteria and protect intestinal mucosa. Diacylglycerol has the property of dissolving VD, anti‐bacterial, and antioxidant effects. The purpose of this study was to explore the potentially synergistic effects of diacylglycerol and VD in ameliorating dextran sodium sulfate‐induced colitis in rats. A 2 × 3 factorial design was used in this experiment, consisting
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Relationships between Very Low-Density Lipoproteins-Ceramides, -Diacylglycerols, and -Triacylglycerols in Insulin-Resistant Men. Lipids (IF 1.919) Pub Date : 2020-05-15 Justine M Mucinski,Camila Manrique-Acevedo,Takhar Kasumov,Timothy J Garrett,Ayman Gaballah,Elizabeth J Parks
This short report describes the relationships between concentrations of ceramides (CER), diacylglycerols (DAG), triacylglycerols (TAG) in very low‐density lipoproteins (VLDL) particles, and hepatic lipid accumulation. VLDL particles were isolated from male subjects (n = 12, mean ± SD, age 42.1 ± 5.4 years, BMI 37.4 ± 4.1 kg/m2, ALT 45 ± 21 U/L) and apolipoprotein B100 (apoB100), VLDL‐TAG, ‐CER, and
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A Simple and Efficient Method for Synthesis of sn-Glycero-Phosphoethanolamine. Lipids (IF 1.919) Pub Date : 2020-05-13 Siddabasave Gowda B Gowda,Hirotoshi Fuda,Yusuke Yamamoto,Hitoshi Chiba,Shu-Ping Hui
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Analysis of Phytochemical Composition of Camellia oleifera Oil and Evaluation of its Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. Lipids (IF 1.919) Pub Date : 2020-05-11 Ming Chang,Fangcheng Qiu,Niannian Lan,Tao Zhang,Xin Guo,Qingzhe Jin,Ruijie Liu,Xingguo Wang
In China, Camellia oleifera oil (COO) is not only a common edible oil but also a traditional remedy widely applied to ameliorate a variety of illnesses associated with inflammation, such as mouth ulcers, thrush, eczema, etc. However, there has been a lack of relevant biological research on the anti‐inflammatory capacity of COO, and the specific bioactive lipid phytochemicals contributing to the anti‐inflammatory
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Birthweight and Lipids in Adult Life: Population-Based Cross Sectional Study. Lipids (IF 1.919) Pub Date : 2020-05-05 Issa Al Salmi,Suad Hannawi
The purpose of this study was to examine the association of birthweight with lipid profile in the general adult population. Participants in the second‐wave of a nationally representative cross sectional AusDiab‐study were asked to complete a birthweight questionnaire. Fasting total cholesterol (TC), LDL‐C, HDL‐C, and triacylglycerol levels were modeled against birthweight. Four thousand five hundred
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Fatty Acids of Microbial Origin in the Perirenal Fat of Rats (Rattus norvegicus domestica) and Guinea Pigs (Cavia porcellus) Fed Various Diets. Lipids (IF 1.919) Pub Date : 2020-04-28 Annelies De Cuyper,Daniela Winkler,Thomas Tütken,Geert P J Janssens,Marcus Clauss
Guinea pigs are assumed to practice caecotrophy to a higher degree than rats. Studies from leporids suggest that through the practice of caecotrophy, hindgut fermenting species could build up microbial fatty acids (FA) in body tissues. We hypothesized that microbial FA would be detectable in the body tissue of guinea pigs and rats, and this to a higher degree in guinea pigs. Twenty‐four rats and guinea
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Theoretical and Kinetic Analysis of the Esterification of Undecylenic Acid with Glycerol. Lipids (IF 1.919) Pub Date : 2020-04-22 Jean-François Fabre,Gildas Nyame Mendendy Boussambe,Romain Valentin,Zéphirin Mouloungui
The synthesis of undecylenic acid partial esters can be performed at mild temperature with a classical esterification reaction catalyzed by dodecylbenzene sulfonic acid (DBSA). A semi‐empirical molecular modeling on the different reaction intermediates indicates that DBSA can strongly decrease their heats of formation through hydrogen bonding. Diester formation seems to be thermodynamically favored
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High Glucose and Liver Fatty Acid Binding Protein Gene Ablation Differentially Impact Whole Body and Liver Phenotype in High-Fat Pair-Fed Mice. Lipids (IF 1.919) Pub Date : 2020-04-20 Gregory G Martin,Danilo Landrock,Avery L McIntosh,Sherrelle Milligan,Kerstin K Landrock,Ann B Kier,John Mackie,Friedhelm Schroeder
Ad libitum‐fed diets high in fat and carbohydrate (especially fructose) induce weight gain, obesity, and nonalcoholic fatty liver disease (NAFLD) in humans and animal models. However, interpretation is complicated since ad libitum feeding of such diets induces hyperphagia and upregulates expression of liver fatty acid binding protein (L‐FABP)—a protein intimately involved in fatty acid and glucose
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Dietary Alcohol and Fat Differentially Affect Plasma Cholesteryl Ester Transfer Activity and Triglycerides in Normo- and Hypertriglyceridemic Subjects. Lipids (IF 1.919) Pub Date : 2020-04-07 John W Gaubatz,Baiba K Gillard,Corina Rosales,Henry J Pownall
Moderate alcohol consumption is associated with increased plasma high‐density lipoprotein (HDL)‐cholesterol concentrations and reduced risk for cardiovascular disease. Plasma cholesteryl ester transfer activity (CETA) mediates the exchange of HDL‐cholesteryl ester (CE) for the triacylglycerol (TAG) of very‐low‐density lipoproteins. We compared the effects of oral challenges of Alcohol, saturated fat
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Lipid Profiles of Five Essential Phospholipid Preparations for the Treatment of Nonalcoholic Fatty Liver Disease: A Comparative Study. Lipids (IF 1.919) Pub Date : 2020-04-07 Christian Lüchtenborg,Birgit Niederhaus,Britta Brügger,Branko Popovic,Gert Fricker
Nonalcoholic fatty liver disease (NAFLD) is associated with an imbalance in fatty acid composition and can progress from simple steatosis to steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. Essential phospholipids (EPL), which contain high levels of 1,2‐dilinoleoylphosphatidylcholine, can be used to treat NAFLD. Polyenylphosphatidylcholine (PPC) preparations are external, commercially
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Spleen Oxylipin and Polyunsaturated Fatty Acid Profiles are Altered by Dietary Source of Polyunsaturated Fatty Acid and by Sex. Lipids (IF 1.919) Pub Date : 2020-04-07 Samantha D Pauls,Mariam Ragheb,Tanja Winter,Shan Leng,Carla G Taylor,Peter Zahradka,Harold M Aukema
As the largest secondary lymphoid organ, the spleen plays an important role in immune responses. The role of arachidonic acid (ARA) and its 20‐carbon eicosanoids in modulating immune function has long been of interest. However, recent advances have enabled the identification of numerous other n‐6 and n‐3 polyunsaturated fatty acid (PUFA)‐derived oxylipins. Here, we investigate the effects of diet and
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β-Cypermethrin Alleviated the Inhibitory Effect of Medium from RAW 264.7 Cells on 3T3-L1 Cell Maturation into Adipocytes. Lipids (IF 1.919) Pub Date : 2020-03-31 Bingnan He,Xia Wang,Xini Jin,Zimeng Xue,Yinhua Ni,Jianbo Zhu,Caiyun Wang,Yuanxiang Jin,Zhengwei Fu
Studies have elucidated that pyrethroids induce adipogenesis. It is also known that macrophages can affect the homeostasis of adipose tissue. However, whether and how the β‐cypermethrin (β‐CYP)‐mediated inhibition of the macrophages affects adipogenesis remain unknown. To explore the effects of β‐CYP on adipogenesis through modulating the function of macrophages, 3T3‐L1 cells, a preadipocyte cell line
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Preferential Partitioning of Rumen-Protected n-3 and n-6 Fatty Acids into Functionally Different Adipose Tissues. Lipids (IF 1.919) Pub Date : 2020-03-26 Christina Wolf,Nicole Gredig,Michael Kreuzer,Susanne E Ulbrich,Joël Berard,Katrin Giller
Lipids are stored at various sites inside the body as adipose tissue (AT). These include subcutaneous, abdominal, and intermuscular locations. The AT substantially differ in their metabolic function. It is, however, unclear whether AT have specific requirements for individual essential n‐3 and n‐6 fatty acids (FA). If so, control mechanisms would partition FA from the blood. To investigate the hypothesis
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