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Icariin regulates RANKL-induced osteoclast differentiation via the ERα/c-Src/RANK signaling Biomed. Mater. (IF 4.0) Pub Date : 2024-02-28 Shaolin Yang, Xiaocui Zhang, Xiaofei Liao, Yi Ding, Juwen Gan
Osteoporosis (OP) is a common metabolic bone disease. Excessive osteoclastic activity significantly contributes to the development of OP. Icariin (ICA) is a flavonol glycoside derived from herbal plants and possesses curative effects on postmenopausal OP and bone fracture. This study aimed to investigate the effects of ICA on osteoclast differentiation induced by receptor activator of nuclear factor
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A facile method to fabricate versatile keratin cryogels for tissue engineering applications Biomed. Mater. (IF 4.0) Pub Date : 2024-02-28 Zhitong Zhao, Huei Min Chua, Hui Ying Lai, Kee Woei Ng
Human hair keratin (HHK) has been extensively explored as a biomaterial for soft tissue regeneration due to their excellent bioactivity and biocompatibility. The possibility to fabricate HHK into three-dimensional (3D) hydrogels with physical properties resembling soft tissues has been well demonstrated. However, conventional keratin hydrogels often exhibit a dense architecture that could hinder cell
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Exploring the efficacy of tryptone-stabilized silver nanoparticles against respiratory tract infection-causing bacteria: a study on planktonic and biofilm forms Biomed. Mater. (IF 4.0) Pub Date : 2024-02-28 Pooja Pandey, Sristi Pradhan, Kimaya Meher, Manu Lopus, Sirisha L Vavilala
Respiratory tract infections (RTIs) are a common cause of mortality and morbidity in the human population. The overuse of antibiotics to overcome such infections has led to antibiotic resistance. The emergence of multidrug resistant bacteria is necessitating the development of novel therapeutic techniques in order to avoid a major global clinical threat. Our study aims to investigate the potential
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Semisolid extrusion 3D printing of Dolutegravir-Chitosan nanoparticles laden polymeric buccal films: personalized solution for pediatric treatment Biomed. Mater. (IF 4.0) Pub Date : 2024-02-27 Priya Dharshini Krishnan, Ramya Devi Durai, Sivanjineyulu Veluri, Vedha Hari B Narayanan
In this work, the semi solid extrusion 3D printing process was utilized to incorporate anti-HIV drug Dolutegravir and its nanoparticles into the buccal film (BF) that was fabricated using the developed polymer ink. The composite made of polyvinyl alcohol (PVA) and sodium alginate was processed into a 3D printing polymer ink with optimum viscosity (9587 ± 219 cP) needed for the seamless extrusion through
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Drug release control and anti-inflammatory effect of biodegradable polymer surface modified by gas phase chemical functional reaction Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Inho Bae, Byung-Hoon Kim
The plasma technique has been widely used to modify the surfaces of materials. The purpose of this study was to evaluate the probability of controlling the prednisolone delivery velocity on a polylactic acid (PLA) surface modified by plasma surface treatment. Surface modification of PLA was performed at a low-pressure radio frequency under conditions of 100 W power, 50 mTorr chamber pressure, 100–200
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Facile cost-effective green synthesis of carbon dots: selective detection of biologically relevant metal ions and synergetic efficiency for treatment of cancer Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Somedutta Maity, Monami Das Modak, Munendra Singh Tomar, Kirti Wasnik, Prem Shankar Gupta, Sukanya Patra, Divya Pareek, Monika Singh, Monica Pandey, Pradip Paik
A facile cost-effective green synthesis approach has been used to synthesize carbon-dot (CDs) from the Kernel part of the Azadirachta Indica seeds and investigated their fluorescent and metal ions sensing capability and also used for the delivery of drugs. Metallic ions such as Ca2+, K+, Na+, Fe3+, and Zn2+ which are biologically important for many reactions and are selectively detected through the
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The effect of Wharton’s jelly-derived stem cells seeded/boron-loaded acellular scaffolds on the healing of full-thickness burn wounds in the rat model Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Sadeneh Nikzad, Saeideh Same, Saeid Safiri, Sanam Dolati, Babak Roushangar Zineh, Shahla Meshgi, Leila Roshangar, Fikrettin Şahin
Burn wounds are the most destructive and complicated type of skin or underlying soft tissue injury that are exacerbated by a prolonged inflammatory response. Several cell-based therapeutic systems through the culturing of potent stem cells on modified scaffolds have been developed to direct the burn healing challenges. In this context, a new regenerative platform based on boron (B) enriched-acellular
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Electrospun zein nanofibers loaded with curcumin as a wound dressing: enhancing properties with PSS and PDADMAC layers Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Nasrin Salehi, Azadeh Ghaee, Hanieh Moris, Sara Derhambakhsh, Mehdi Mansour Sharifloo, Farzaneh Safshekan
Development of wound dressings with enhanced therapeutic properties is of great interest in the modern healthcare. In this study, a zein-based nanofibrous wound dressing containing curcumin as a therapeutic agent was fabricated through electrospinning technique. In order to achieve desirable properties, such as antibacterial characteristics, reduced contact angle, and enhanced mechanical properties
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Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Abinaya Shanmugavadivu, Sundaravadhanan Lekhavadhani, P J Miranda, Nagarajan Selvamurugan
Osteosarcoma (OS) is a malignant bone neoplasm plagued by poor prognosis. Major treatment strategies include chemotherapy, radiotherapy, and surgery. Chemotherapy to treat OS has severe adverse effects due to systemic toxicity to healthy cells. A possible way to overcome the limitation is to utilize nanotechnology. Nanotherapeutics is an emerging approach in treating OS using nanoparticulate drug delivery
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The development of an in vitro human hair follicle organoid with a complexity similar to that in vivo Biomed. Mater. (IF 4.0) Pub Date : 2024-02-23 Paulo André Marinho, Gyusang Jeong, Seung Hyun Shin, Su Na Kim, Hyeongwon Choi, Sung Hoon Lee, Byung Cheol Park, Yong Deog Hong, Hyoung-June Kim, Won-Seok Park
In vitro hair follicle (HF) models are currently limited to ex vivo HF organ cultures (HFOCs) or 2D models that are of low availability and do not reproduce the architecture or behavior of the hair, leading to poor screening systems. To resolve this issue, we developed a technology for the construction of a human in vitro hair construct based on the assemblage of different types of cells present in
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An in vitro three-dimensional (3D) testicular organoid culture system for efficient gonocyte maintenance and propagation using frozen/thawed neonatal bovine testicular tissues Biomed. Mater. (IF 4.0) Pub Date : 2024-02-20 Shiyan Tang, Celine Jones, Rajwa Mecca, Jill Davies, Sheila Lane, Kevin Coward
Fertility preservation in prepubertal boys with cancer requires the cryopreservation of immature testicular tissues (ITTs) prior to gonadotoxic treatment. However, the limited number of germ cells in small human ITT biopsies necessitates the development of an in vitro culture system for germ cell expansion using frozen-thawed ITTs. Here, we generated testicular organoids for the in vitro maintenance
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Devitrite (Na2Ca3Si6O16) phase dominated nanostructured 45S5 bioactive glass: exploring its structural and biological properties Biomed. Mater. (IF 4.0) Pub Date : 2024-02-16 K Elakkiya, C Ashok Raja, S Balakumar
This research study is primarily centred around calcination temperature and time influence on phase formation in bioactive glasses (BGs). In the present study, BG with a nominal composition of 45S5 was synthesized through the sol–gel process. The developed BGs then underwent heat treatment for various sintering durations and temperatures. X-ray diffraction (XRD) patterns of the BGs reveals that the
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Bioactive gelatin-sheets as novel biopapers to support prevascularization organized by laser-assisted bioprinting for bone tissue engineering Biomed. Mater. (IF 4.0) Pub Date : 2024-02-16 Olivia Kérourédan, Ayako Washio, Charles Handschin, Raphaël Devillard, Shoichiro Kokabu, Chiaki Kitamura, Yasuhiko Tabata
Despite significant advances in the management of patients with oral cancer, maxillofacial reconstruction after ablative surgery remains a clinical challenge. In bone tissue engineering, biofabrication strategies have been proposed as promising alternatives to solve issues associated with current therapies and to produce bone substitutes that mimic both the structure and function of native bone. Among
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Steroid hormone receptor based gene delivery systems as potential oral cancer therapeutics Biomed. Mater. (IF 4.0) Pub Date : 2024-02-15 Dwaipayan Bhattacharya, Madhu Rani Bharati, Kalyani Sakhare, Piyush Khandelia, Rajkumar Banerjee, Kumar Pranav Narayan
Glucocorticoid and Mineralocorticoid receptors are principally ligand-dependent intracellular transcription factors that are known to influence the development and growth of many human cancers. Our study investigates the potential of these receptors to act as a target for oral cancer treatment since findings in this regard are sparse till date. Leveraging the aberrant behavior of steroid hormone receptors
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The role of decellularized cell derived extracellular matrix in the establishment and culture of in vitro breast cancer tumor model Biomed. Mater. (IF 4.0) Pub Date : 2024-02-15 Atakan Tevlek
Decades of research have shown that two-dimensional cell culture studies are insufficient for preclinical cancer diagnosis and treatment, and that cancer cells in three-dimensional (3D) culture systems have better cell–cell and cell–matrix interactions, gene expression, heterogeneity, and structural complexity that more closely resemble in vivo tumors. Researchers are still optimizing 3D culturing
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Micromechanics of fibrous scaffolds and their stiffness sensing by cells Biomed. Mater. (IF 4.0) Pub Date : 2024-02-14 Dhruba Jyoti Mech, Mohd Suhail Rizvi
Mechanical properties of the tissue engineering scaffolds are known to play a crucial role in cell response. Therefore, an understanding of the cell-scaffold interactions is of high importance. Here, we have utilized discrete fiber network model to quantitatively study the micromechanics of fibrous scaffolds with different fiber arrangements and cross-linking densities. We observe that localized forces
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Organic-inorganic biohybrid films from wool-keratin/jellyfish-collagen/silica/boron via sol-gel reactions for soft tissue engineering applications Biomed. Mater. (IF 4.0) Pub Date : 2024-02-13 Safiye Nur Yildiz, Tugba Sezgin Arslan, Yavuz Emre Arslan
Therapeutic angiogenesis is pivotal in creating effective tissue-engineered constructs that deliver nutrients and oxygen to surrounding cells. Hence, biomaterials that promote angiogenesis can enhance the efficacy of various medical treatments, encompassing tissue engineering, wound healing, and drug delivery systems. Considering these, we propose a rapid method for producing composite silicon-boron-wool
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Braided biomimetic PCL grafts for anterior cruciate ligament repair and regeneration Biomed. Mater. (IF 4.0) Pub Date : 2024-02-13 Sanazar Kadyr, Ulpan Nurmanova, Bakhytbol Khumyrzakh, Aida Zhakypbekova, Dina Saginova, Nurgul Daniyeva, Cevat Erisken
Anterior cruciate ligament (ACL) is a knee joint stabilizer with a limited regeneration capacity mainly because of low cellular content. State-of-the-art procedures are unable to restore the functions of the tissue as demonstrated by limited success rates. Regenerative engineering can offer a solution for restoring the functions of torn/ruptured ligaments provided that biomimetic grafts are available
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Advantages and limitations of using cell viability assays for 3D bioprinted constructs Biomed. Mater. (IF 4.0) Pub Date : 2024-02-13 Sofia Avnet, Gemma Di Pompo, Giorgia Borciani, Tiziana Fischetti, Gabriela Graziani, Nicola Baldini
Bioprinting shows promise for bioengineered scaffolds and three-dimensional (3D) disease models, but assessing the viability of embedded cells is challenging. Conventional assays are limited by the technical problems that derive from using multi-layered bioink matrices dispersing cells in three dimensions. In this study, we tested bioprinted osteogenic bioinks as a model system. Alginate- or gelatin-based
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Improving rodents and humans cardiac cell maturity in vitro through polycaprolactone and polyurethane nanofibers Biomed. Mater. (IF 4.0) Pub Date : 2024-02-12 Zuzanna Iwoń, Ewelina Krogulec, Aleksandra Kierlańczyk, Patrycja Baranowska, Iwona Łopianiak, Michal Wojasiński, Elżbieta Jastrzębska
Currently, numerous studies are conducted using nanofibers as a scaffold for culture cardiac cells; however, there still needs to be more research evaluating the impact of the physicochemical properties of polymer nanofibers on the structure and function of cardiac cells. We have studied how poly(ϵ-caprolactone) and polyurethane nanofibrous mats with different physicochemical properties influence the
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Biomimetic short fiber reinforced 3-dimensional scaffold for bone tissue regeneration Biomed. Mater. (IF 4.0) Pub Date : 2024-02-09 Liangqiang Sun, Mingming Liu, Yaqiang Li, Shuhua Zhang, Tonghe Zhu, Juan Du, Atta Ur Rehman Khan
Bone defects caused by diseases and trauma are considered serious clinical challenges. Autologous and allogeneic transplantations are the most widely used methods to mitigate bone defects. However, transplantation poses risks such as secondary trauma, immune rejection, and disease transmission to patients. Preparing a biologically active bone tissue engineering scaffold as a bone substitute can overcome
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Bacteria-targeted magnolol-loaded multifunctional nanocomplexes for antibacterial and anti-inflammatory treatment Biomed. Mater. (IF 4.0) Pub Date : 2024-02-09 Jian Jiang, Xuefeng Hou, Kangjie Xu, Kangkang Ji, Zhongkai Ji, Juqun Xi, Xin Wang
Natural plant-derived small molecules have shown great potential for their antimicrobial and anti-inflammatory properties. In this study, we successfully developed a nanocomplex consisting of magnolol (Mag), a surfactant with an 18 carbon hydrocarbon chain and multi-amine head groups (C18N3), and a peptide (cyclic 9-amino acid peptide (CARG)) with targeting capabilities for Staphylococcus aureus (S
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Injectable hydrogel with antimicrobial and anti-inflammatory properties for postoperative tumor wound care Biomed. Mater. (IF 4.0) Pub Date : 2024-02-08 Xinyun Li, Dandan Xing, Yangjing Bai, Yangrui Du, Shiying Lang, Kaijun Li, Jun Xiang, Gongyan Liu, Shan Liu
Clinically, tumor removal surgery leaves irregularly shaped wounds that are susceptible to bacterial infection and further lead to excessive inflammation. Injectable hydrogel dressings with antimicrobial and anti-inflammatory properties have been recognized as an effective strategy to care for postoperative tumor wounds and prevent recurrence in recent years. In this work, we constructed a hydrogel
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Neural repair and regeneration interfaces: a comprehensive review Biomed. Mater. (IF 4.0) Pub Date : 2024-02-07 Baoning Sha, Zhanhong Du
Neural interfaces play a pivotal role in neuromodulation, as they enable precise intervention into aberrant neural activity and facilitate recovery from neural injuries and resultant functional impairments by modulating local immune responses and neural circuits. This review outlines the development and applications of these interfaces and highlights the advantages of employing neural interfaces for
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A comparative analysis of the cytocompatibility, protein adsorption, osteogenic and angiogenic properties of the 45S5- and S53P4-bioactive glass compositions Biomed. Mater. (IF 4.0) Pub Date : 2024-02-07 Fabian Westhauser, Marcela Arango-Ospina, Leena Hupa, Tobias Renkawitz, Aldo R Boccaccini, Elke Kunisch
Despite their long history of application in orthopedics, the osteogenic and angiogenic properties as well as the cytocompatibility and protein adsorption of the 45S5- (in wt%: 45.0 SiO2, 24.5 Na2O, 24.5 CaO, 6.0 P2O5) and S53P4- (in wt%: 53.0 SiO2, 23.0 Na2O, 20.0 CaO, 4.0 P2O5) bioactive glass (BG) compositions have not yet been directly compared in one and the same experimental setting. In this
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Optimization of hybrid gelatin-polysaccharide bioinks exploiting thiol-norbornene chemistry using a reducing additive Biomed. Mater. (IF 4.0) Pub Date : 2024-02-05 Nathan Carpentier, Laurens Parmentier, Louis Van der Meeren, André G Skirtach, Peter Dubruel, Sandra Van Vlierberghe
Thiol-norbornene chemistry offers great potential in the field of hydrogel development, given its step growth crosslinking mechanism. However, limitations exist with regard to deposition-based bioprinting of thiol-containing hydrogels, associated with premature crosslinking of thiolated (bio)polymers resulting from disulfide formation in the presence of oxygen. More specifically, disulfide formation
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Use of antioxidant nanoliposomes for co-delivery of PTEN plasmids and plumbagin to induce apoptosis in hepatic cancer cells Biomed. Mater. (IF 4.0) Pub Date : 2024-02-05 Stuti Bhagat, Sanjay Singh
Hepatocellular carcinoma remains a challenging contributor to the global cancer and related mortality, and claims approximately 800,000 deaths each year. Dysregulation or loss of function mutations involving the tumor suppressor gene, phosphatase and tensin homolog deleted on chromosome ten (PTEN), has been well-characterized in various cancers to elicit anomalous cell proliferation and oncogenic transformation
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Nanoparticles loaded with β-Lapachone and Fe3+ exhibit enhanced chemodynamic therapy by producing H2O2 through cascaded amplification Biomed. Mater. (IF 4.0) Pub Date : 2024-02-05 Yibo Yang, Jia Zhang, Shihe Liu, Xin Zhang, Zhimin Bai, Shuai Wang, Kun Li, Ming Shi, Zhiwei Liu, Jidong Wang, Jian Li
The rapid, irreversible change of active Fe2+ to inactive Fe3+ after the Fenton reaction occurring reduces the chemodynamic therapeutic (CDT) effect. Therefore, manipulation of the tumor microenvironment to provide sufficient hydrogen peroxide (H2O2) while maintaining metal ion catalyst activity is critical for effective CDT. Here, β-Lapachone (LPC) was loaded by mesoporous silica nanoparticles (MSNs)
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In vivo soft tissue regenerative potential of flax seed mucilage self-assembled collagen aerogels Biomed. Mater. (IF 4.0) Pub Date : 2024-01-30 Punam Kumari, Kannoth Madappurakkal Ahina, Kiruba Kannan, Sreelekshmi Sreekumar, Rachita Lakra, Uma Tiruchirapalli Sivagnanam, Manikantan Syamala Kiran
The present study demonstrates the in vivo soft tissue regenerative potential of flax seed mucilage (FSM) reinforced collagen aerogels in Wistar rats. The physiochemical, mechanical, and thermal properties were significantly improved upon the incorporation of flax mucilage into collagen when compared to the native collagen scaffold. In addition, the functional group of flax mucilage notably contributed
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Enhancing the therapeutic potential of curcumin: a novel nanoformulation for targeted anticancer therapy to colorectal cancer with reduced miR20a and miR21 expression Biomed. Mater. (IF 4.0) Pub Date : 2024-01-25 Qusay S Atwan, Israa Al-Ogaidi
Curcumin (Cur) possesses remarkable pharmacological properties, including cardioprotective, neuroprotective, antimicrobial, and anticancer activities. However, the utilization of Cur in pharmaceuticals faces constraints owing to its inadequate water solubility and limited bioavailability. To overcome these hurdles, there has been notable focus on exploring innovative formulations, with nanobiotechnology
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Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties Biomed. Mater. (IF 4.0) Pub Date : 2024-01-25 Tariq O Abbas, Hemalatha Parangusan, Huseyin C Yalcin, Mohamed Hassan, Lubna Zakrif, Nooshin Zandi, Cristian P Pennisi
Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being explored for the fabrication of scaffolds that promote urethral regeneration and healing. In this study, we present an approach to fabricate a trilayer hybrid scaffold comprising a central
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Synthesis of Fe3O4 core/MIL-100(Fe) shell nanocomposites for tumor chemo-ferroptosis combination therapy and MR imaging Biomed. Mater. (IF 4.0) Pub Date : 2024-01-25 Antong Jiang, Teng Wang, Xiaoling Lu, Yuxiang Tian, Zihan Jiang, Bin Xu, Hanyuan Zhang, Weijun Fang
The application of both chemotherapy and ferrotherapy together has shown great potential in increasing the effectiveness of cancer treatment. To achieve such a combination, we herein have synthesized Fe3O4 core/MIL-100(Fe) shell nanocomposites (FM) that can be used for tumor chemo-ferroptosis combination therapy. In these nanocomposites, the anticancer drug 10-hydroxycamptothecin (HCPT) and iron ions
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Facile preparation of self-healing hydrogels based on chitosan and PVA with the incorporation of curcumin-loaded micelles for wound dressings Biomed. Mater. (IF 4.0) Pub Date : 2024-01-25 Peng Ding, Xiaoyue Ding, Jingyu Li, Wei Guo, Oseweuba Valentine Okoro, Mahta Mirzaei, Yanfang Sun, Guohua Jiang, Amin Shavandi, Lei Nie
The increased demand for improved strategies for wound healing has, in recent years, motivated the development of multifunctional hydrogels with favorable bio-compatibility and antibacterial properties. To this regard, the current study presented the design of a novel self-healing composite hydrogel that could perform as wound dressing for the promotion of wound healing. The composite hydrogels were
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T1-weighted MRI of targeting atherosclerotic plaque based on CD40 expression on engulfed USPIO’s cell surface Biomed. Mater. (IF 4.0) Pub Date : 2024-01-25 Chen Huang, Wentao Huang, Yixuan Meng, Chengqian Zhou, Xiaozhuan Wang, Chunyu Zhang, Yuzhen Tian, Wei Wei, Yongsheng Li, Quan Zhou, Wenli Chen, Yukuan Tang
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of cholesterol within the arterial wall. Its progression can be monitored via magnetic resonance imaging (MRI). Ultrasmall Superparamagnetic Particles of Iron Oxide (USPIO) (<5 nm) have been employed as T1 contrast agents for MRI applications. In this study, we synthesized USPIO with an average surface carboxylation
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Mesoporous silica nanoparticles accommodating electrospun nanofibers as implantable local drug delivery system processed by cold atmospheric plasma and spin coating approaches Biomed. Mater. (IF 4.0) Pub Date : 2024-01-24 Nursu Erdoğan, Didem Şen Karaman, Özlem Yıldız, Gizem Dilara Özdemir, Utku Kürşat Ercan
Nanofibers (NF) and nanoparticles are attractive for drug delivery to improve the drug bioavailability and administration. Easy manipulation of NF as macroscopic bulk material give rise to potential usages as implantable local drug delivery systems (LLDS) to overcome the failures of systemic drug delivery systems such as unmet personalized needs, side effects, suboptimal dosage. In this study, poly(ethylene
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A ROS-responsive loaded desferoxamine (DFO) hydrogel system for traumatic brain injury therapy Biomed. Mater. (IF 4.0) Pub Date : 2024-01-24 Yun Qiu, Yu Zeng, Chun Zhang, Xiaorui Lv, Yating Ling, Yu Si, Tao Guo, Yinying Ni, Jingwen Zhang, Changgen Xu, Ziyu Wang, Jiabo Hu
Traumatic brain injury (TBI) produces excess iron, and increased iron accumulation in the brain leads to lipid peroxidation and reactive oxygen species (ROSs), which can exacerbate secondary damage and lead to disability and death. Therefore, inhibition of iron overload and oxidative stress has a significant role in the treatment of TBI. Functionalized hydrogels with iron overload inhibiting ability
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Small molecule conjugation reduces macrophage uptake and increases in vivo blood circulation of polystyrene nanoparticles Biomed. Mater. (IF 4.0) Pub Date : 2024-01-24 Devyani Yenurkar, Maria Ruocco, Pragya1, Lily Liang, Sudip Mukherjee
Nanomedicine often failed clinically to show therapeutic efficacy due to reduced particle circulation and enhanced capture by the reticuloendothelial system, including the liver. Developing novel immunomodulatory surface coating can prevent macrophage capture and increase the particle circulation of the nanomedicine, resulting in higher therapeutic efficiency. Herein, we demonstrate the development
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Azadirachta indica (AI) leaf extract coated ZnO-AI nanocore–shell particles for enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) Biomed. Mater. (IF 4.0) Pub Date : 2024-01-24 Bhumika Sharma, Dipika Upadhyaya, Pratik Deshmukh, Sourabrata Chakraborty, Khageswar Sahu, Srinibas Satapathy, Shovan Kumar Majumder
With the rise in microbial resistance to traditional antibiotics and disinfectants, there is a pressing need for the development of novel and effective antibacterial agents. Two major approaches being adopted worldwide to overcome antimicrobial resistance are the use of plant leaf extracts and metallic nanoparticles (NPs). However, there are no reports on the antibacterial potential of NPs coated with
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Ce-doped MgO films on AZ31 alloy substrate for biomedical applications: preparation, characterization and testing Biomed. Mater. (IF 4.0) Pub Date : 2024-01-23 Marwa Hattab, Samia Ben Hassen, Silvia Spriano, Sara Ferraris, Marin Cernea, Yasser Ben Amor
Magnesium ions, MgO nanoparticles and thin films, magnesium alloys and cerium compounds are materials intensively studied due to their corrosion protection, antibacterial and pharmacological properties. In this work, we have designed, prepared and investigated, novel thin films of MgO doped with cerium, deposited on Mg alloy (AZ31) for temporary implants, in order to enhance their life time. More precisely
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A heparin-based nanogel system for redox and pH dual-responsive delivery of cisplatin Biomed. Mater. (IF 4.0) Pub Date : 2024-01-22 Huong Nguyen Thi, Son Nguyen Ngoc, Thanh Vu Minh, Quan Le Van, Vu Thuy Duong Bui, Ngoc Hoi Nguyen
Heparin recently has been discovered as a novel anti-cancer agent. The combinations of heparin with other agents was reported not only to reduce the undesired effects of free heparin and increase the cellular uptake of the delivered molecules, but also is the basis for the design and development of multi-stimulation response systems to improve their killing cancer cell efficiency at the target positions
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Self-assembled coating with a metal-polyphenolic network for intraocular lens modification to prevent posterior capsule opacification Biomed. Mater. (IF 4.0) Pub Date : 2024-01-22 Yunqing Wang, Chan Wen, Ruihua Jing, Yunfei Yang, Yazhou Qin, Tiantian Qi, Conghui Hu, Xinshan Bai, Changrui Wu, Cheng Pei
Posterior capsule opacification (PCO) is a main complication after cataract surgery and intraocular lens (IOLs) implantation and is attributed to residual lens epithelial cells (LECs) migrating to the IOL surface and posterior capsules. IOL surface modification has been a newly-developing research filed in recent years; however, the applicability and economical acquisition of modified materials remain
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In vitro analysis of insoluble salt formation mechanism associated with Mg corrosion—variations depending on the diffusion environment in model tissue Biomed. Mater. (IF 4.0) Pub Date : 2024-01-22 Masanobu Hayashi, Akiko Yamamoto, Takayuki Aizawa, Yu Yusa, Yoshinaka Shimizu, Yoshimichi Imai
Magnesium (Mg) alloys have attracted attention as biodegradable metals, but the details of their corrosion behavior under biological environment have not been elucidated. Previous studies have suggested that diffusion through blood flow may influence Mg corrosion. Therefore, to understand the degradation behaviors of Mg, we analyzed insoluble salt precipitation associated with Mg corrosion in model
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Production of alginate macrocapsule device for long-term normoglycaemia in the treatment of type 1 diabetes mellitus with pancreatic cell sheet engineering Biomed. Mater. (IF 4.0) Pub Date : 2024-01-19 Büşra Öncel Duman, Yusufhan Yazir, Zehra Seda Halbutoğullari, Serap Mert, Ahmet Öztürk, Gülçin Gacar, Gökhan Duruksu
Type 1 diabetes-mellitus (T1DM) is characterized by damage of beta cells in pancreatic islets. Cell-sheet engineering, one of the newest therapeutic approaches, has also been used to create functional islet systems by creating islet/beta cell-sheets and transferring these systems to areas that require minimally invasive intervention, such as extrahepatic areas. Since islets, beta cells, and pancreas
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Bioactive self-assembling silk fibroin–sericin films for skin tissue engineering Biomed. Mater. (IF 4.0) Pub Date : 2024-01-19 Prasanna Kumar Byram, Mandrita Mukherjee, Motiur Rahaman, Hema Bora, Manish Kaushal, Santanu Dhara, Nishant Chakravorty
The quest for an ideal wound dressing material has been a strong motivation for researchers to explore novel biomaterials for this purpose. Such explorations have led to the extensive use of silk fibroin (SF) as a suitable polymer for several applications over the years. Unfortunately, another major silk protein—sericin has not received its due attention yet in spite of having favorable biological
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Fiber configuration determines foreign body response of electrospun scaffolds: in vitro and in vivo assessments Biomed. Mater. (IF 4.0) Pub Date : 2024-01-19 Qiaolin Ma, Xiaoyi Wang, Bei Feng, Chao Liang, Xinjian Wan, Mohamed El-Newehy, Meera Moydeen Abdulhameed, Xiumei Mo, Jinglei Wu
Biomaterial scaffolds boost tissue repair and regeneration by providing physical support, delivering biological signals and/or cells, and recruiting endogenous cells to facilitate tissue-material integration and remodeling. Foreign body response (FBR), an innate immune response that occurs immediately after biomaterial implantation, is a critical factor in determining the biological outcomes of biomaterial
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Biomimetic mineralization of platelet lysate/oxidized dextran cryogel as a macroporous 3D composite scaffold for bone repair Biomed. Mater. (IF 4.0) Pub Date : 2024-01-19 Şükran Şeker, Dilara Aral, Ayşe Eser Elçin, Elçin Yaşar Murat
Scaffold development approaches using autologous sources for tissue repair are of great importance in obtaining bio-active/-compatible constructs. Platelet-rich plasma (PRP) containing various growth factors and platelet lysate (PL) derived from PRP are autologous products that have the potential to accelerate the tissue repair response by inducing a transient inflammatory event. Considering the regenerative
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Evaluation of antimicrobial photodynamic action of a pluronic and pectin based film loaded with methylene blue against methicillin resistant Staphylococcus aureus Biomed. Mater. (IF 4.0) Pub Date : 2024-01-19 Sourabrata Chakraborty, Shivangi Shukla, Mahima Rastogi, Sai Sarbani Mund, Anupam Chowdhury, Chandrachur Mukherjee, Khageswar Sahu, Shovan Kumar Majumder
Antimicrobial wound dressings play a crucial role in treatment of wound infections. However, existing commercial options fall short due to antibiotic resistance and the limited spectrum of activity of newly emerging antimicrobials against bacteria that are frequently encountered in wound infections. Antimicrobial photodynamic therapy (aPDT) is very promising alternative therapeutic approach against
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Assessing the advantages of 3D bioprinting and 3D spheroids in deciphering the osteoarthritis healing mechanism using human chondrocytes and polarized macrophages Biomed. Mater. (IF 4.0) Pub Date : 2024-01-19 Nilotpal Majumder, Subhadeep Roy, Aarushi Sharma, Shuchi Arora, Raju Vaishya, Amitabha Bandyopadhyay, Sourabh Ghosh
The molecular niche of an osteoarthritic microenvironment comprises the native chondrocytes, the circulatory immune cells, and their respective inflammatory mediators. Although M2 macrophages infiltrate the joint tissue during osteoarthritis (OA) to initiate cartilage repair, the mechanistic crosstalk that dwells underneath is still unknown. Our study established a co-culture system of human OA chondrocytes
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Amrubicin encapsulated PLGA NPs inhibits the PI3K/AKT signaling pathway by activating PTEN and inducing apoptosis in TMZ-resistant Glioma Biomed. Mater. (IF 4.0) Pub Date : 2024-01-16 Muhammad Younis, Sana Shaikh, Khawar Ali Shahzad, Fei Tan, Zhao Wang, Mushtaq Hussain Lashari
Glioblastoma (GBM) remains a challenging malignancy due to its aggressive nature and the lack of efficacious therapeutic interventions. Nanotechnology-based approaches exhibit promise in GBM treatment; however, the successful translation of these strategies from preclinical models to clinical settings is hindered by inefficient nanoparticle clearance from vital organs. Addressing this concern, we investigated
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Fabrication of bioactive glass/phosphorylated chitosan composite scaffold and its effects on MC3T3-E1 cells Biomed. Mater. (IF 4.0) Pub Date : 2024-01-16 Liu Wenxiu, Han Guojiang, Qin Liying, Dong Wenli, Han Baoqin, Jin Liming, Yang Yan
This study aimed to synthesize bioactive glass (BG) and phosphorylated chitosan (PCS), and fabricate a BG/PCS composite scaffold. The physical properties (mechanical strength, swelling degree, and degradation rate) of the BG/PCS scaffold were tested. The in vitro mineralization properties of composite scaffolds in simulated body fluid were investigated. MC3T3-E1 cell responses with the BG/PCS scaffold
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Inorganic nanocarriers for siRNA delivery for cancer treatments Biomed. Mater. (IF 4.0) Pub Date : 2024-01-16 Ganeshlenin Kandasamy, Dipak Maity
RNA interference is one of the emerging methodologies utilized in the treatment of a wide variety of diseases including cancer. This method specifically uses therapeutic RNAs (TpRNAs) like small interfering RNAs (siRNAs) to regulate/silence the cancer-linked genes, thereby minimizing the distinct activities of the cancer cells while aiding in their apoptosis. But, many complications arise during the
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Ciliary neurotrophic factor mediated growth of retinal ganglion cell axons on PGS/PCL scaffolds Biomed. Mater. (IF 4.0) Pub Date : 2024-01-12 Sanaz Behtaj, Fereshteh Karamali, Samaneh Najafian, Elahe Masaeli, Maksym Rybachuk
Ciliary neurotrophic factor (CNTF) promotes survival and/or differentiation of a variety of neuronal cells including retinal ganglion cells (RGCs). Delivery of CNTF requires a suitable medium capable of mediating diffusion and premature release of CNTF within the target tissue. Polymeric tissue-engineered scaffolds have been readily used as substrates for cell transplantation, expansion, and differentiation
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Oxygen self-supplied nanoparticle for enhanced chemiexcited photodynamic therapy Biomed. Mater. (IF 4.0) Pub Date : 2023-12-22 Liman Liang, Yueying Wang, Chensa Zhang, Yulu Chang, Yuzi Wang, Jinyan Xue, Lu Wang, Fan Zhang, Kui Niu
Photodynamic therapy (PDT) is a promising strategy for effective cancer treatment. However, it still faces severe challenges, including poor laser penetration and insufficient oxygen (O2) in solid tumors. Here, we constructed intelligent O2 self-supplied nanoparticles (NPs) for tumor hypoxia relief as well as effective chemiexcited PDT. Oxygen-carrying NPs (BSA@TCPO NPs) were obtained via the self-assembly
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Enhancement of nerve regeneration through schwann cell-mediated healing in a 3D printed polyacrylonitrile conduit incorporating hydrogel and graphene quantum dots: a study on rat sciatic nerve injury model Biomed. Mater. (IF 4.0) Pub Date : 2023-12-21 Elham Hoveizi
Despite recent technological advancements, effective healing from sciatic nerve damage remains inadequate. Cell-based therapies offer a promising alternative to autograft restoration for peripheral nerve injuries, and 3D printing techniques can be used to manufacture conduits with controlled diameter and size. In this study, we investigated the potential of Wharton’s jelly-derived mesenchymal stem
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Effects of using collagen and aloe vera grafted fibroin scaffolds on osteogenic differentiation of rat bone marrow mesenchymal stem cells in SBF-enriched cell culture medium Biomed. Mater. (IF 4.0) Pub Date : 2023-12-14 Salma A Taher Mohamed, Nuray Emin
In the study, collagen and aloe vera were grafted onto silk fibroin with two different methods, and 3D-microporous scaffolds (1F5C4A1 and 2F5C4A1) were formed by lyophilization. Three osteogenic cultures were started by seeding rat bone marrow mesenchymal stem cells (MSCs) and pre-induced MSC (osteoblast (OB)) on biopolymeric scaffolds. The osteogenic medium was enriched with 10% (v/v) simulated body
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High-strength and high-toughness ECM films with the potential for peripheral nerve repair Biomed. Mater. (IF 4.0) Pub Date : 2023-12-12 Fangfang Wang, Haiyang Wang, Xiaotong Shan, Jin Mei, Peng Wei, Qinghua Song, Weiwei Chen
Extracellular matrix (ECM) scaffolds are widely applied in the field of regeneration as the result of their irreplaceable biological advantages, and the preparation of ECM scaffolds into ECM hydrogels expands the applications to some extent. However, weak mechanical properties of current ECM materials limit the complete exploitation of ECM’s biological advantages. To enable ECM materials to be utilized
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A leptin-loaded poly-ϵ-caprolactone 3D printing scaffold for odontoblastic differentiation in human dental pulp cells Biomed. Mater. (IF 4.0) Pub Date : 2023-12-08 Eun-Hyo Cho, Ye-Seul Kim, Young-Ran Kim, Jin-Ho Kang, Sang-Won Park, Hyun-Pil Lim, Kwi-Dug Yun, Woo-Hyung Jang, Jeong-Tea Koh, Chan Park, Bin-Na Lee
This study investigated the effects on odontoblast differentiation of a 3D-printed poly-ϵ-caprolactone (PCL) scaffold that incorporated leptin. Material extrusion-type 3D printing with a 43 000-molecular weight PCL material was used to fabricate a PCL scaffold with a 6 mm diameter, 1 mm height, and 270–340 µm pore size. The experimental groups were PCL scaffolds (control group), PCL scaffolds with
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An ECM-mimicking assembled gelatin/hyaluronic acid hydrogel with antibacterial and radical scavenging functions for accelerating open wound healing Biomed. Mater. (IF 4.0) Pub Date : 2023-12-07 Xuebin Ma, Wenli Ning, Yiming Geng, Huarong Shao, Yang Liu, Fei Liu, Daizhou Zhang, Bo Chi, Yali Hou, Xiao Fu
A multifunctional hydrogel dressing with hemostatic, antibacterial, and reactive oxygen species (ROS)-removing properties is highly desirable for the clinical treatment of open wounds. Although many wound dressings have been prepared, the modification of polymers is often involved in the preparation process, and the uncertainty of biological safety and stability of modified polymers hinders the clinical
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Decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through Wnt/β-catenin signaling pathway regulation Biomed. Mater. (IF 4.0) Pub Date : 2023-12-04 Xiaochen Su, Menghao Teng, Yingang Zhang, Wenchen Ji
Spinal cord injury (SCI) causes tissue destruction and neuronal apoptosis, which impede neural function recovery. Therefore, promoting neuronal regeneration and neural pathway reconstruction is crucial. In this study, a novel and facile decellularized extracellular matrix (dECM) scaffold seeded with adipose-derived stem cells (ADSCs) (dECM scaffolds/ADSCs) was reported. The dECM scaffold maintained
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Design and development of a hepatic lyo-dECM powder as a biomimetic component for 3D-printable hybrid hydrogels Biomed. Mater. (IF 4.0) Pub Date : 2023-12-04 Giulia M Di Gravina, Elia Bari, Stefania Croce, Franca Scocozza, Silvia Pisani, Bice Conti, Maria A Avanzini, Ferdinando Auricchio, Lorenzo Cobianchi, Maria Luisa Torre, Michele Conti
Bioprinting offers new opportunities to obtain reliable 3D in vitro models of the liver for testing new drugs and studying pathophysiological mechanisms, thanks to its main feature in controlling the spatial deposition of cell-laden hydrogels. In this context, decellularized extracellular matrix (dECM)-based hydrogels have caught more and more attention over the last years because of their characteristic