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Reactive Halogen Species: Role in Living Systems and Current Research Approaches Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Yuliya V. Khramova, Veronika A. Katrukha, Victoria V. Chebanenko, Alexander I. Kostyuk, Nikolay P. Gorbunov, Oleg M. Panasenko, Alexey V. Sokolov, Dmitry S. Bilan
Abstract Reactive halogen species (RHS) are highly reactive compounds that are normally required for regulation of immune response, inflammatory reactions, enzyme function, etc. At the same time, hyperproduction of highly reactive compounds leads to the development of various socially significant diseases – asthma, pulmonary hypertension, oncological and neurodegenerative diseases, retinopathy, and
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Post-Translational Oxidative Modifications of Hemostasis Proteins: Structure, Function, and Regulation Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Mark A. Rosenfeld, Lyubov V. Yurina, Elizaveta S. Gavrilina, Alexandra D. Vasilyeva
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Multicomponent DNAzyme Nanomachines: Structure, Applications, and Prospects Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Daria D. Nedorezova, Maria S. Rubel, Aleksandr A. Rubel
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Formation of Supplementary Metal-Binding Centers in Proteins under Stress Conditions Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Olga V. Kosmachevskaya, Natalia N. Novikova, Sergey N. Yakunin, Alexey F. Topunov
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Fenton Reaction in vivo and in vitro. Possibilities and Limitations Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Konstantin O. Muranov
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Animal Models of FUS-Proteinopathy: A Systematic Review Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Alexander Rezvykh, Daniil Shteinberg, Evgeny Bronovitsky, Aleksey Ustyugov, Sergei Funikov
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G-Quadruplexes as Sensors of Intracellular Na+/K+ Ratio: Potential Role in Regulation of Transcription and Translation Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Olga D. Lopina, Svetlana V. Sidorenko, Dmitry A. Fedorov, Elizaveta A. Klimanova
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Biomolecular Condensates: Structure, Functions, Methods of Research Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Natalia A. Gorsheneva, Julia V. Sopova, Vladimir V. Azarov, Anastasia V. Grizel, Aleksandr A. Rubel
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The Role of Vitamin K in the Development of Neurodegenerative Diseases Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Anna I. Diachenko, Igor A. Rodin, Tatiana N. Krasnova, Oleg I. Klychnikov, Lidia N. Nefedova
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Synthetic Biology Approaches to Posttranslational Regulation in Plants Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Inna A. Abdeeva, Yulia S. Panina, Liliya G. Maloshenok
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Electroanalysis in Pharmacogenomic Studies: Mechanisms of Drug Interaction with DNA Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Victoria V. Shumyantseva, Veronica V. Pronina, Tatiana V. Bulko, Lyubov E. Agafonova
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Free Radical Lipid Peroxidation Induced by Reactive Halogen Species Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Oleg M. Panasenko, Yury A. Vladimirov, Valery I. Sergienko
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Impairment of Assembly of the Vimentin Intermediate Filaments Leads to Suppression of Formation and Maturation of Focal Contacts and Alteration of the Type of Cellular Protrusions Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Anna O. Zholudeva, Nikolay S. Potapov, Ekaterina A. Kozlova, Maria E. Lomakina, Antonina Y. Alexandrova
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Serum Glycome as a Diagnostic and Prognostic Factor in Gestational Diabetes Mellitus Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Ognjen Radojičić, Lucia Pažitná, Zorana Dobrijević, Paras Kundalia, Kristina Kianičková, Jaroslav Katrlík, Vesna Mandić Marković, Željko Miković, Olgica Nedić, Dragana Robajac
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Natural Activators of Autophagy Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Julia A. Pavlova, Ekaterina A. Guseva, Olga A. Dontsova, Petr V. Sergiev
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Synthetic Activators of Autophagy Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Ekaterina A. Guseva, Julia A. Pavlova, Olga A. Dontsova, Petr V. Sergiev
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The Functions of N6-Methyladenosine in Nuclear RNAs Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Nadezhda A. Zhigalova, Katerina Yu. Oleynikova, Alexey S. Ruzov, Alexander S. Ermakov
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N-Terminal Fragment of Cardiac Myosin Binding Protein C Modulates Cooperative Mechanisms of Thin Filament Activation in Atria and Ventricles Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Anastasia M. Kochurova, Evgenia A. Beldiia, Victoria V. Nefedova, Natalia S. Ryabkova, Daria S. Yampolskaya, Alexander M. Matyushenko, Sergey Y. Bershitsky, Galina V. Kopylova, Daniil V. Shchepkin
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Influence of Nucleotide Context on Non-Specific Amplification of DNA with Bst exo– DNA Polymerase Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Ravil R. Garafutdinov, Olga Yu. Kupova, Assol R. Sakhabutdinova
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Synthesis and Biological Properties of Polyphenol-Containing Linear and Dendrimeric Cationic Peptides Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Artem A. Shatilov, Sergey M. Andreev, Anastasiya V. Shatilova, Evgeny A. Turetskiy, Renata A. Kurmasheva, Marina O. Babikhina, Larisa V. Saprygina, Nadezhda N. Shershakova, Dar’ya K. Bolyakina, Valeriy V. Smirnov, Igor P. Shilovsky, Musa R. Khaitov
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Pathogenetic Significance of Long Non-Coding RNAs in the Development of Thoracic and Abdominal Aortic Aneurysms Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Aksana N. Kucher, Iuliia A. Koroleva, Maria S. Nazarenko
Abstract Aortic aneurysm (AA) is a life-threatening condition with a high prevalence and risk of severe complications. The aim of this review was to summarize the data on the role of long non-coding RNAs (lncRNAs) in the development of AAs of various location. Within less than a decade of studies on the role of lncRNAs in AA, using experimental and bioinformatic approaches, scientists have obtained
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Immunology of SARS-CoV-2 Infection Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Aida G. Gabdoulkhakova, Rimma N. Mingaleeva, Albina M. Romozanova, Aisylu R. Sagdeeva, Yulia V. Filina, Albert A. Rizvanov, Regina R. Miftakhova
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Direct Determination of the Structure of Single Biopolymer Molecules Using Nanopore Sequencing Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract This review highlights operational principles, features, and modern aspects of the development of third-generation sequencing technology of biopolymers focusing on the nucleic acids analysis, namely the nanopore sequencing system. Basics of the method and technical solutions used for its realization are considered, from the first works showing the possibility of creation of these systems to
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Tumor Organoids: The Era of Personalized Medicine Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract The strategies of future medicine are aimed to modernize and integrate quality approaches including early molecular-genetic profiling, identification of new therapeutic targets and adapting design for clinical trials, personalized drug screening (PDS) to help predict and individualize patient treatment regimens. In the past decade, organoid models have emerged as an innovative in vitro platform
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Leaf Extract from European Olive (Olea europaea L.) Post-Transcriptionally Suppresses the Epithelial-Mesenchymal Transition and Sensitizes Gastric Cancer Cells to Chemotherapy Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract The overall survival of patients with the advanced and recurrent gastric cancer (GC) remains unfavorable. In particular, this is due to cancer spreading and resistance to chemotherapy associated with the epithelial-mesenchymal transition (EMT) of tumor cells. EMT can be identified by the transcriptome profiling of GC for EMT markers. Indeed, analysis of the TCGA and GTEx databases (n = 408)
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Genomic Imprinting and Random Monoallelic Expression Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome
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Phenoptosis and the Various Types of Natural Selection Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Giacinto Libertini
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Opposite Effects of CRABP1 and CRABP2 Homologs on Proliferation of Breast Cancer Cells and Their Sensitivity to Retinoic Acid Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Adel D. Enikeev, Pavel M. Abramov, Danila S. Elkin, Andrey V. Komelkov, Anastasiya A. Beliaeva, Darya M. Silantieva, Elena M. Tchevkina
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Serotonin Receptors as a Potential Target in the Treatment of Alzheimer’s Disease Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Dmitrii V. Eremin, Elena M. Kondaurova, Aleksander Ya. Rodnyy, Camilla A. Molobekova, Dmitrii A. Kudlay, Vladimir S. Naumenko
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Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer’s Disease Signs Development Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Alena O. Burnyasheva, Natalia A. Stefanova, Nataliya G. Kolosova, Darya V. Telegina
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Dicarbonyl-Modified Low-Density Lipoproteins Are Key Inducers of LOX-1 and NOX1 Gene Expression in the Cultured Human Umbilical Vein Endotheliocytes Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Vadim Z. Lankin, Mars G. Sharapov, Alla K. Tikhaze, Ruslan G. Goncharov, Olga A. Antonova, Galina G. Konovalova, Vladimir I. Novoselov
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Impact of Lipid Matrix Composition on Activity of Membranotropic Enzymes Galactonolactone Oxidase from Trypanosoma cruzi and L-Galactono-1,4-Lactone Dehydrogenase from Arabidopsis thaliana in the System of Reverse Micelles Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Andrey A. Chudin, Elena V. Kudryashova
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Effect of Dexamethasone on Adhesion of Human Neutrophils and Concomitant Secretion Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Svetlana I. Galkina, Ekaterina A. Golenkina, Natalia V. Fedorova, Alexander L. Ksenofontov, Marina V. Serebryakova, Vladimir I. Stadnichuk, Ludmila A. Baratova, Galina F. Sud’ina
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The Role of Ubiquitin–Proteasome System in the Biology of Stem Cells Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Alexander V. Burov, Andrey A. Rodin, Vadim L. Karpov, Alexey V. Morozov
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A New Mouse Strain with a Mutation in the NFE2L2 (NRF2) Gene Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Evgeniy S. Egorov, Natalia D. Kondratenko, Olga A. Averina, Oleg A. Permyakov, Maria A. Emelyanova, Anastasia S. Prikhodko, Ludmila A. Zinovkina, Petr V. Sergiev, Roman A. Zinovkin
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Topology of Ubiquitin Chains in the Chromatosomal Environment of the E3 Ubiquitin Ligase RNF168 Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Anna A. Kudriaeva, Lyudmila A. Yakubova, George A. Saratov, Vasiliy I. Vladimirov, Valeriy M. Lipkin, Alexey A. Belogurov
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Nocistatin and Products of Its Proteolysis Are Dual Modulators of Type 3 Acid-Sensing Ion Channels (ASIC3) with Algesic and Analgesic Properties Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Dmitry I. Osmakov, Nadezhda V. Tarasova, Andrey A. Nedorubov, Victor A. Palikov, Yulia A. Palikova, Igor A. Dyachenko, Yaroslav A. Andreev, Sergey A. Kozlov
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Low-Frequency Oscillations of Bacteriochlorophyll Oligomers in Chlorosomes of Photosynthetic Green Bacteria Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Andrei G. Yakovlev, Alexandra S. Taisova, Zoya G. Fetisova
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The Role of Aurora B Kinase in Normal and Cancer Cells Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Ekaterina Titova, Galina Shagieva, Vera Dugina, Pavel Kopnin
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Changes in the Structure of Potato Virus A Virions after Limited in situ Proteolysis According to Tritium Labeling Data and Computer Simulation Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Alexander L. Ksenofontov, Ludmila A. Baratova, Pavel I. Semenyuk, Natalia V. Fedorova, Gennadii A. Badun
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Relationships among Development, Growth, Body Size, Reproduction, Aging, and Longevity – Trade-Offs and Pace-Of-Life Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Rong Yuan, Erin Hascup, Kevin Hascup, Andrzej Bartke
Abstract Relationships of growth, metabolism, reproduction, and body size to the biological process of aging and longevity have been studied for decades and various unifying “theories of aging” have been proposed to account for the observed associations. In general, fast development, early sexual maturation leading to early reproductive effort, as well as production of many offspring, have been linked
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Potential Geroprotectors – From Bench to Clinic Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Alexey A. Moskalev
Abstract Geroprotectors are substances that slow down aging process and can be used for prevention of age-related diseases. Geroprotectors can improve functioning of various organ systems and enhance their homeostatic capabilities. We have developed a system of criteria for geroprotectors and proposed their classification based on the mechanisms of their action on the aging processes. Geroprotectors
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DNA Instability in Neurons: Lifespan Clock and Driver of Evolution Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Varvara E. Dyakonova
Abstract In the last ten years, the discovery of neuronal DNA postmitotic instability has changed the theoretical landscape in neuroscience and, more broadly, biology. In 2003, A. M. Olovnikov suggested that neuronal DNA is the “initial substrate of aging”. Recent experimental data have significantly increased the likelihood of this hypothesis. How does neuronal DNA accumulate damage and in what genome
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Olovnikov, Telomeres, and Telomerase. Is It Possible to Prolong a Healthy Life? Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Yegor E. Yegorov
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“If I Were in Nature’s Place, I Would Do It Like This...” Life and Hypotheses of Alexey Olovnikov Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Natalia I. Olovnikova, Ivan A. Olovnikov, Alla I. Kalmykova
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Microgravity Effects and Aging Physiology: Similar Changes or Common Mechanisms? Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Andrey Yu. Ratushnyy, Ludmila B. Buravkova
Abstract Despite the use of countermeasures (including intense physical activity), cosmonauts and astronauts develop muscle atony and atrophy, cardiovascular system failure, osteopenia, etc. All these changes, reminiscent of age-related physiological changes, occur in a healthy person in microgravity quite quickly – within a few months. Adaptation to the lost of gravity leads to the symptoms of aging
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Apelin C-Terminal Fragments: Biological Properties and Therapeutic Potential Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Oleg I. Pisarenko, Irina M. Studneva
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Immune Privileges as a Result of Mutual Regulation of Immune and Stem Systems Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Dmitriy V. Karpenko
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Actuarial Aging Rates in Human Cohorts Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Leonid A. Gavrilov, Natalia S. Gavrilova
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Pathological Correlates of Cognitive Decline in Parkinson’s Disease: From Molecules to Neural Networks Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Nikolai I. Novikov, Elena S. Brazhnik, Valentina F. Kitchigina
Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the death of dopaminergic neurons in the substantia nigra and appearance of protein aggregates (Lewy bodies) consisting predominantly of α-synuclein in neurons. PD is currently recognized as a multisystem disorder characterized by severe motor impairments and various non-motor symptoms. Cognitive decline is one
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Retrotransposons and Telomeres Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Alla I. Kalmykova, Olesya A. Sokolova
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Response of PRIMPOL-Knockout Human Lung Adenocarcinoma A549 Cells to Genotoxic Stress Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Anastasia S. Gromova, Elizaveta O. Boldinova, Daria V. Kim, Roman N. Chuprov-Netochin, Sergey V. Leonov, Margarita V. Pustovalova, Dmitry O. Zharkov, Alena V. Makarova
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Function of the Conserved Non-Functional Residues in Apomyoglobin – to Determine and to Preserve Correct Topology of the Protein Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Valentina E. Bychkova, Dmitry A. Dolgikh, Vitalii A. Balobanov
Abstract In this paper the answer to O. B. Ptitsyn’s question “What is the role of conserved non-functional residues in apomyoglobin” is presented, which is based on the research results of three laboratories. The role of conserved non-functional apomyoglobin residues in formation of native topology in the molten globule state of this protein is revealed. This fact allows suggesting that the conserved
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Methods for Assessment of Nucleotide Excision Repair Efficiency Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Aleksei A. Popov, Irina O. Petruseva, Natalya V. Naumenko, Olga I. Lavrik
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Differences in Structural Changes and Pathophysiological Effects of Low-Density Lipoprotein Particles upon Accumulation of Acylhydroperoxy Derivatives in Their Outer Phospholipid Monolayer or upon Modification of Apoprotein B-100 by Natural Dicarbonyls Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Vadim Z. Lankin, Alla K. Tikhaze, Galina G. Konovalova
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Role of Mitochondrial DNA in Yeast Replicative Aging Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-01
Abstract Despite the diverse manifestations of aging across different species, some common aging features and underlying mechanisms are shared. In particular, mitochondria appear to be among the most vulnerable systems in both metazoa and fungi. In this review, we discuss how mitochondrial dysfunction is related to replicative aging in the simplest eukaryotic model, the baker’s yeast Saccharomyces
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Viral Vectors in Gene Replacement Therapy Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-01
Abstract Throughout the years, several hundred million people with rare genetic disorders have been receiving only symptom management therapy. However, research and development efforts worldwide have led to the development of long-lasting, highly efficient, and safe gene therapy for a wide range of hereditary diseases. Improved viral vectors are now able to evade the preexisting immunity and more efficiently
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Lel A. Drachev and the Direct Electrometric Method Biochemistry Moscow (IF 2.8) Pub Date : 2023-10-26 Vasily V. Ptushenko, Alexey Y. Semenov
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Ion Channels in Electrical Signaling in Higher Plants Biochemistry Moscow (IF 2.8) Pub Date : 2023-10-26 Maxim A. Mudrilov, Maria M. Ladeynova, Darya V. Kuznetsova, Vladimir A. Vodeneev
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Electrical Signals at the Plasma Membrane and Their Influence on Chlorophyll Fluorescence of Chara Chloroplasts in vivo Biochemistry Moscow (IF 2.8) Pub Date : 2023-10-26 Alexander A. Bulychev, Stepan Yu. Shapiguzov, Anna V. Alova