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Effect of Zanthoxylum alkylamides on glucose metabolism in streptozotocin-induced diabetic Sprague–Dawley rats Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-21 Rui Wang; Yu-ming You; Xiong Liu
This research aimed at investigating the hypoglycemic effect of Zanthoxylum alkylamides and whether TRPV1 receptor could participate in the glucose metabolism by using streptozotocin-induced diabetic rat model. The results showed that the blood glucose measured in the Zanthoxylum alkylamides treated group (ALK) showed significantly lower values than that in the model group (Model). Significant improvements
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Effects of brewer’s spent grain biochar on the growth and quality of leaf lettuce (Lactuca sativa L. var. crispa.) Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-20 Jun-Hyuk Yoo; Deogratius Luyima; Jae-Han Lee; Seong-Yong Park; Jun-Woo Yang; Ji-Young An; Yeo-Uk Yun; Taek-Keun Oh
The need for organic soil amendments is increasing in the Republic of Korea against the backdrop of increased soil acidification and nutrient losses. The pyrolysis of biomass produces biochar which not only increases soil productivity but also provides environmental benefits through carbon sequestration. The portion of the brewer’s spent grain (BSG) recycled is by far less than the amount generated
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Anti-bacterial effect of phytoconstituents isolated from Alimatis rhizoma Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-19 Chengfu Li; Wei Yan; Enji Cui; Changji Zheng
Five compounds including three triterpenoids and two sesquiterpenes were isolated from Alimatis rhizoma. Their chemical structures were determined to be alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alismol (4) and alismoxide (5) by various spectroscopic analysis, including 1H-NMR, 13C-NMR, HMBC and MS spectra. Compounds 1–5 were evaluated for their antibacterial potential against
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Evaluation of the hepato-renal functions and antimicrobial activity of fatty amido benzoic acid synthesised from Citrullus colocynthis seed oil Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-18 Adewale Adewuyi; Chiagoziem A. Otuechere; Nkechi H. Ellah; Shiva Shanker Kaki; Scott O. Fayemi; Charles B. Adeosun
Rapid progression in resistance to antimicrobial agents by pathogenic organisms is a serious concern. This study aimed to synthesize fatty amido benzoic acid (FBA) from Citrullus colocynthis seed oil (CCO) and evaluate its safety profile as an alternative bioactive agent for combating drug-resistant pathogens. FBA was synthesised through simple chemical reaction route and examined for its antioxidant
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Synbiotic supplementation with prebiotic Schizophyllum commune derived β-(1,3/1,6)-glucan and probiotic concoction benefits gut microbiota and its associated metabolic activities Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-17 Vineet Singh; Karthika Muthuramalingam; Young Mee Kim; Sanggyu Park; Sung Hong Kim; Jongdae Lee; Changlim Hyun; Tatsuya Unno; Moonjae Cho
Synbiotics synergistically favors beneficial effects of prebiotics and probiotics towards host metabolic health by modulating gut ecosystem. In this study, we sought to examine the effects of prebiotics (Schizophyllum commune derived β-(1,3/1,6)-glucan), probiotics (concoction made of eight different bacterial strains) and synbiotics (prebiotics + probiotics) on gut microbiota and its associated metabolic
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Oxidative stability of chia seed oil and flax seed oil and impact of rosemary (Rosmarinus officinalis L.) and garlic (Allium cepa L.) extracts on the prevention of lipid oxidation Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-16 Hyojik Jung; Inhwan Kim; Sunghyeon Jung; Jihyun Lee
Chia seed and flax seed oils are rich in polyunsaturated fatty acids, but are susceptible to oxidative deterioration. The aim of this study was to determine the oxidative stability of chia seed and flax seed oils and enhance the stability using rosemary or garlic extracts. During accelerated storage at 65 °C for 14 days, the antioxidant abilities of rosemary or garlic extracts were evaluated and compared
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Expression pattern analysis of three R2R3-MYB transcription factors for the production of anthocyanin in different vegetative stages of Arabidopsis leaves Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-15 Yeonjong Koo; R. Scott Poethig
Anthocyanin is a type of flavonoid that appears purple in plants. PAP1, PAP2, and MYB113 are the three major R2R3-MYB transcription factors that regulate flavonoid biosynthesis in Arabidopsis thaliana. In this study, we found that the three MYB genes regulate anthocyanin accumulation in different leaf stages. Under limited nutrient conditions, PAP1 and PAP2 genes were highly induced in juvenile leaves
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Antiplatelet effect of cudraxanthone B is related to inhibition of calcium mobilization, αIIbβ3 activation, and clot retraction Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-12 Jung-Hae Shin; Muhammad Irfan; Man Hee Rhee; Hyuk-Woo Kwon
Cudrania tricuspidata (C. tricuspidata) is widespread throughout Asia and has known to have various physiological activities such as, inflammation, diabetes, obesity and tumor. Cudrania tricuspidata, a rich source of xanthones and flavonoids, have been investigated phytochemically and biologically. However, research of these compounds on platelets is limited. Therefore, we searched for a new substance
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Metabolomic analysis reveals the interaction of primary and secondary metabolism in white, pale green, and green pak choi (Brassica rapa subsp. chinensis) Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-09 Hyeon Ji Yeo; Seung-A Baek; Ramaraj Sathasivam; Jae Kwang Kim; Sang Un Park
This study aimed to comprehensively analyze primary and secondary metabolites of three different-colored (white, pale green, and green) pak choi cultivars (Brassica rapa subsp. chinensis) using gas chromatography attached with time-of-flight mass spectrometry (GC-TOFMS) and high-performance liquid chromatography (HPLC). In total, 53 primary metabolites were identified and subjected to partial least-squares
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Bioassay-guided isolation and identification of anti-obesity phytochemicals from fruits of Amomum tsao-ko Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-08 Seong Su Hong; Chun Whan Choi; Ji Eun Lee; Yeon Woo Jung; Jung A. Lee; Wonsik Jeong; Yun-Hyeok Choi; Hanna Cha; Eun-Kyung Ahn; Joa Sub Oh
Amomum tsao-ko (Zingiberaceae), an important traditional medicinal herb, possesses many biological activities, including anti-inflammatory effects. Though the anti-obesity properties of the crude ethanol extract of A. tsao-ko fruits have been reported, the anti-adipogenic properties of its phytochemical constituents have not been reported. Therefore, in the present study, we isolated the active constituents
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Double-stranded RNA confers resistance to pepper mottle virus in Nicotiana benthamiana Appl. Biol. Chem. (IF 1.838) Pub Date : 2021-01-07 Jeongyeon Yoon; Miao Fang; Dowhan Lee; Minsu Park; Kook-Hyung Kim; Chanseok Shin
RNA interference (RNAi) is a regulatory mechanism of gene expression mediated by small RNAs. By using the RNAi technique, exogenous double-stranded RNA (dsRNA) designed to target mRNA, suppresses target gene expression levels in plants. In this study, we adopted the RNAi mechanism as a tool to protect plants from viruses. We designed and synthesized several dsRNAs targeting the pepper mottle virus
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Correction to: Dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis and their cytotoxicity on human cancer cell lines Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-12-23 Sung‑Kyu Choi; Yeong‑Geun Lee; Rong Bo Wang; Hyoung‑Geun Kim; Dahye Yoon; Dae Young Lee; Yeon‑Ju Kim; Nam‑In Baek
An amendment to this paper has been published and can be accessed via the original article.
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Sulforaphane induces colorectal cancer cell proliferation through Nrf2 activation in a p53-dependent manner Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-12-12 Yunjeong Gwon; Jisun Oh; Jong-Sang Kim
Sulforaphane is a well-known phytochemical that stimulates nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant cellular response. In this study, we found that sulforaphane promoted cell proliferation in HCT116 human colon cancer cells expressing a normal p53 gene in a dose-dependent but biphasic manner. Since p53 has been reported to contribute to cell survival by regulating various
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Effect of lemon peel flavonoids on anti-fatigue and anti-oxidation capacities of exhaustive exercise mice Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-12-11 Guili Bao; Yinglong Zhang; Xiaoguang Yang
In this study, lemon peel flavonoids (LPF) were administered to investigate its effect on the anti-fatigue and antioxidant capacity of mice that undergo exercise until exhaustion. LPF (88.36 min in LPFH group mice) significantly increased the exhaustion swimming time compare to the untreated mice (40.36 min), increased the liver glycogen and free fatty acid content in mice and reduce lactic acid and
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Validation of an optimized HPLC/UV method for the quantification of flavonoids in lotus Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-12-08 Ju Sung Lee; Leo Adrianne Paje; Won-Hee Choi; Eun Ju Cho; Hyun Young Kim; Sonia D. Jacinto; Sanghyun Lee
Flavonoids present in the leaves of lotus (Nelumbo nucifera) grown in different regions of South Korea (Yeongcheon, Haenam, and Seocheon) and at different harvest times (July to September) were determined. Flavonoid contents in lotus extracts were identified and analyzed using high-performance liquid chromatography (HPLC). The HPLC results revealed that the flavonoid contents of the lotus extracts
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Removal of TPH, UCM, PAHs, and Alk-PAHs in oil-contaminated soil by thermal desorption Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-12-05 Byeongwook Choi; Sungjong Lee; Eun Hea Jho
Oil-contaminated soils from a former landfill and gas station site in Korea were treated by thermal desorption. The removal efficiencies of the different oil components such as total petroleum hydrocarbons (TPH), polyaromatic hydrocarbons (PAHs), unresolved complex mixtures (UCM), and alkylated PAHs (Alk-PAHs) by thermal desorption were determined. The effects of temperatures (200, 400, and 600 °C)
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Anticancer activities of cyclohexenone derivatives Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-27 Soon Young Shin; Jihyun Park; Yearam Jung; Young Han Lee; Dongsoo Koh; Youngdae Yoon; Yoongho Lim
We designed 21 ethyl 3,5-diphenyl-2-cyclohexenone-6-carboxylate derivatives to identify compounds exhibiting anticancer activity. To measure the inhibitory effects of the compounds on cancer cell growth, a long-term survival clonogenic assay was performed. Since compounds containing a cyclohexenone moiety inhibit the enzyme acetylcholinesterase, an in vitro acetylcholinesterase assay was performed
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Celastrol-mediated autophagy regulation in cancer Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-25 Muhammad Haroon; Sun Chul Kang
In the last few decades, studies on autophagy regulation and its potential role in cancer therapeutics have expanded to include detailed mechanisms. Since apoptosis exhibits drug resistance in some cancers, efforts have focused on searching for compounds with autophagy modulating properties. Numerous natural compounds have been used in cancer treatment and are considered a significant research area
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Teratogenic and developmental toxic effects of etridiazole on zebrafish (Danio rerio) embryos Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-24 Bala Murali Krishna Vasamsetti; Nam-Seok Kim; Kyongmi Chon; Hong-Hyun Park
Etridiazole (EDZ), a thiadiazole-containing toxic chemical, is widely used as a fungicide. Regular usage of EDZ may reach and contaminate water bodies, but its adverse effects on aquatic vertebrates have not been well studied. Therefore, the present study aimed to evaluate the harmful effects of EDZ using zebrafish (ZF) (Danio rerio) embryos. ZF embryos were treated with 3.75, 7.5, 15, 30, and 60 mg/L
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Screening marine algae metabolites as high-affinity inhibitors of SARS-CoV-2 main protease (3CLpro): an in silico analysis to identify novel drug candidates to combat COVID-19 pandemic Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-21 Ghazala Muteeb; Adil Alshoaibi; Mohammad Aatif; Md. Tabish Rehman; M. Zuhaib Qayyum
The recent dissemination of SARS-CoV-2 from Wuhan city to all over the world has created a pandemic. COVID-19 has cost many human lives and created an enormous economic burden. Although many drugs/vaccines are in different stages of clinical trials, still none is clinically available. We have screened a marine seaweed database (1110 compounds) against 3CLpro of SARS-CoV-2 using computational approaches
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Bisphenol A disrupts inflammatory responses via Nod-like receptor protein 3 pathway in macrophages Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-20 Hee-Weon Lee; Sang Keun Ha; Yoonsook Kim
Bisphenol A (BPA) is a harmful endocrine disruptor that is found in polycarbonate plastics such as plastic food containers and in epoxy resins such as dental resins. In the current study, we investigated the effect of BPA on function of inflammatory responses involving activation of Nod-like receptor protein 3 (NLRP3) inflammasome. Treatment with BPA decreased nitric oxide (NO) production and expression
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β-Glucogallin isolated from Fusidium coccineum and its enhancement of skin barrier effects Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-19 Hyoung-Geun Kim; Ki Sun Kim; Minji Kim; Sang-Hwan Shin; Yeong-Geun Lee; Myun-Ho Bang; Dong-Geol Lee; Nam-In Baek
Soil has been used for treatment of wound and skin diseases and for cosmetic purposes. Fusidium coccineum (FC) SA-1FC (Ascomycota) is a fungus found in nature, and its by-products are present in humid soils with plant humus. This study investigates the medium of fermented FC as a covering for all skin problems, including dryness, inflammation, and wounds. A preliminary study revealed that an alcohol
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Molecular characterization of HEXOKINASE1 in plant innate immunity Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-17 Wu Jing; Shahab Uddin; Rupak Chakraborty; Duong Thu Van Anh; Donah Mary Macoy; Si On Park; Gyeong Ryul Ryu; Young Hun Kim; Joon‑Yung Cha; Woe-Yeon Kim; Min Gab Kim
Hexokinase1 (HXK1) is an Arabidopsis glucose sensor that has a variety of roles during plant growth and devlopment, including during germination, flowering, and senescence. HXK1 also acts as a positive regulator of plant immune responses. Previous research suggested that HXK1 might influence plant immune responses via responses to glucose. Plant immune responses are governed by two main pathways: PAMP-triggered
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Antiproliferation effect of sulforaphene isolated from radish (Raphanus sativus L.) seeds on A549 cells Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-11 Sooyeon Lim; Jin-Chul Ahn; Eun Jin Lee; Jongkee Kim
Sulforaphene (SFE), a major isothiocyanate in radish seeds, is a close chemical relative of sulforaphane (SFA) isolated from broccoli seeds and florets. The anti-proliferative mechanisms of SFA against cancer cells have been well investigated, but little is known about the potential anti-proliferative effects of SFE. In this study, we showed that SFE purified from radish seeds inhibited the growth
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Anti-inflammatory effects of 18-nor-ent-pimara-9(11),15-diene-4β-ol isolated from the roots of Aralia continentalis on LPS-induced in RAW264.7 cells Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-09 Hyun Ji Eo; Youngki Park; Seong Su Hong; Gwang Hun Park
Aralia continentalis (A. continentalis) is a medicinal plant belonging to Araliaceae, it has been reported to exert anti-cancer, anti-bacterial, anti-inflammatory, anti-platelet and anti-oxidative activities. But the potential mechanism for the anti-inflammatory effect of compounds isolated from the roots of A. continentalis is still insufficient. So, we evaluated whether compounds isolated from the
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Ameliorative effects of ark clams (Scapharca subcrenata and Tegillarca granosa) on endothelial dysfunction induced by a high-fat diet Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-07 Saoraya Chanmuang; Orawan Meemalai; Kitipong Promyo; Kyung-Hee Park; Suthipong Pongworn; Dal-Seong Gong; Min-Ho Oak; Jeong-Yong Cho; Seong-Gook Kang; Kyung-Sik Ham
Endothelial dysfunction is directly involved in consequence of various metabolic syndromes such as diabetes and hypertension. In this study, we investigated the preventive effects of two ark clams [ark shell (AS, Scapharca subcrenata) and granular ark (GA, Tegillarca granosa)] on endothelial dysfunction induced by a high-fat diet. Wistar rats were divided into four groups as follows: control (normal
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Impacts of peat on nitrogen conservation and fungal community composition dynamics during food waste composting Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-06 Zaihua He; Qiang Li; Xiaoyi Zeng; Kai Tian; Xiangshi Kong; Xingjun Tian
Peat, as a heterogeneous mixture of decaying plant debris and microbial residues, has been widely used in many fields. However, little research focused on the impact of peat addition on food waste composting. To fill this gap, a composting experiment of food waste mixed with five varying percent peat 0, 5, 10, 15, and 20% (w/w, dry weight) was designed to investigate the effect of different dosages
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Sorption and leaching characteristics of pesticides in volcanic ash soils of Jeju Island, Korea Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-04 Won-Pyo Park; Kong-Man Chang; Hae-Nam Hyun; Kyung-Hwan Boo; Bon-Jun Koo
It is important to evaluate leaching behavior in agricultural soils to prevent the pollution of groundwater by pesticides. We identified the distribution coefficients (Kd) of ten pesticides with different physicochemical properties and compared their leaching characteristics using wick lysimeters from three distinct soil types on Jeju Island. The Kd values varied by pesticide and soil, but were within
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Particle size of ginseng (Panax ginseng Meyer) insoluble dietary fiber and its effect on physicochemical properties and antioxidant activities Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-04 Guihun Jiang; Zhaogen Wu; Kashif Ameer; Shanji Li; Karna Ramachandraiah
Dietary fibers (DFs) and associated phytochemicals in ginseng species are known to provide various functional and health benefits. The incorporation of ginseng insoluble dietary fiber (IDF) in food products often result in undesirable physicochemical properties. Thus, to overcome such demerits, micronization of IDF has been considered. This study investigated the effect of particle size on the physicochemical
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Determination of veterinary pharmaceutical runoffs from a swine manure pile using LC–MS/MS Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-11-03 Min-Kyu Park; Joo-Yeon Oh; Sung-Eun Lee; Sung-Deuk Choi
The mass usage of veterinary pharmaceuticals in farms has contributed to environmental pollution in vicinity waters, soils, and sediments from farms and composting facilities. In the present study, we investigated the usage of four antibiotics (viz., lincomycin, sulfamethazine, sulfamethoxazole, and trimethoprim) to understand their contamination routes from livestock manure piles. Residual levels
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Efficiencies of unconventional bulking agents in composting food waste in Korea Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-10-31 Jae-Han Lee; Deogratius Luyima; Chang-Hoon Lee; Seong-Jin Park; Taek-Keun Oh
Sawdust is the main bulking agent used to compost food waste in Korea but it is not an economically desirable choice because its availability entirely depends on imports. Since food waste composting provides agricultural, environmental and economic benefits, it is vital that we search for suitable replacements to sawdust from the locally available materials. In this study, we assessed the composting
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Inhibition of human liver cancer cell growth by evodiamine involves apoptosis and deactivation of PI3K/AKT pathway Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-10-23 Jia Jia; Xigang Kang; Yanfang Liu; Jianwei Zhang
Evodiamine is an active alkaloid member found in Traditional Chinese Herb (TCH) Evodia rutaecarpa. It has been reported to exhibit remarkable biological and medicinal activities including anticancer and anti-inflammatory. This study was designed to investigate the anticancer effects of evodiamine against human liver cancer and evaluate its effects on cell migration, cell invasion, cellular apoptosis
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Physicochemical changes during 4 weeks ripening of Camembert cheeses salted with four types of salts Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-10-06 Hyung Churl Bae; Joong Hyeon Nam; Gereltuya Renchinkhand; Suk-Ho Choi; Myoung Soo Nam
The objectives of this study were to compare physicochemical, rheological and sensory characteristics of Camembert cheeses salted with 4 types of salts (refined salt, baked refined salt, sun-dried salt, and Himalayan rock salt) during 4 weeks ripening period. The pH of Camembert cheese was 7.2 in the sun-dried salt, which was the highest than the other three types of salts. The viable lactic acid bacteria
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Gene flow from transgenic soybean, developed to obtain recombinant proteins for use in the skin care industry, to non-transgenic soybean Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-10-03 Do Young Kim; Min Sik Eom; Hye Jin Kim; Eun Mi Ko; In-Soon Pack; Jung-Ho Park; Kee Woong Park; Kyong-Hee Nam; Sung Duk Oh; Jae Kwang Kim; Ju Seok Seo; Chang-Gi Kim
Soybean has been recognized as a useful platform for heterologous protein production. This study compared the pollen characteristics of transgenic and non-transgenic soybean and investigated the rate of gene flow from transgenic soybean events, developed to obtain recombinant proteins (such as human epidermal growth factor, insulin-like growth factor 1, or thioredoxin) for use in the skin care industry
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Machine learning for a rapid discrimination of ginseng cultivation age using 1H-NMR spectra Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-10-01 Wonho Lee; Dahye Yoon; Seohee Ma; Dae Young Lee; Jae Won Lee; Ick-Hyun Jo; Taekwang Kim; Suhkmann Kim
The scientific and systematic classification of cultivation age is important for preventing age falsification and ensuring the quality of ginseng. Therefore, we applied deep learning to classify the cultivation age of ginseng. Deep learning, which is based on an artificial neural network, is one of the new class of models for machine learning, and is state-of-the-art. It is a powerful tool and has
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Human neutrophil elastase inhibitory dihydrobenzoxanthones and alkylated flavones from the Artocarpus elasticus root barks Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-29 Yeong Jun Ban; Aizhamal Baiseitova; Mohd Azlan Nafiah; Jeong Yoon Kim; Ki Hun Park
Neutrophil elastases are deposited in azurophilic granules interspace of neutrophils and tightly associated with inflammatory ailments. The root barks of Artocarpus elasticus had a strong inhibitory potential against human neutrophil elastase (HNE). The responsible components for HNE inhibition were confirmed as alkylated flavones (2–4, IC50 = 14.8 ~ 18.1 μM) and dihydrobenzoxanthones (5–8, IC50 = 9
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Biogas potential and methanogenic community shift in in-situ anaerobic sewage sludge digestion with food waste leachate additions Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-26 Ji Su Bae; Yeo Myung Yoon; Seon Kyoung Shin; Dong Jin Lee; Dong Cheol Seo
The objective of this study was to determine methane yields (MY) of organic wastes in biogasification facilities according to the mixing ratio of food waste/food waste leachate and sewage sludge. One biogasification facility that treated sewage sludge only was compared with three biogasification facilities treating sewage sludge and food waste. The theoretical MY was derived based on analyses of carbohydrate
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The anti-obesity effect of lotus leaves on high-fat-diet-induced obesity by modulating lipid metabolism in C57BL/6J mice Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-25 Ya Wu; Fang Tan; Tianyu Zhang; Binglin Xie; Lixian Ran; Xin Zhao
Lotus leaves (Nelumbo nucifera) are widely used in medicines and foods. The investigate systematically studied the anti-obesity effect of lotus leaf extracts. It could reduce body weight, alleviate liver damage, and inhibit fat accumulation in high-fat-diet-induced obese mice. Lotus leaf extracts reduced serum alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (AKP)
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Discrimination and quality evaluation of fifteen components in Stauntonia hexaphylla leaves from different harvest time by HPLC–PDA–ESI–MS/MS and ELSD coupled with multivariate statistical analysis and anti-inflammatory activity evaluation Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-24 Dan Gao; Le Ba Vinh; Chong Woon Cho; Kyoung Won Cho; Young Ho Kim; Jong Seong Kang
The leaves of Stauntonia hexaphylla (SHL) are a very popular herbal medicine in Korea because it can be used to treat rheumatic osteoporosis and other diseases. However, owing to the inconsistency in harvesting time and growth years, their quality is uneven, which indirectly negatively affects the safety of this medication. Therefore, the difference of constituents in SHL harvested at different seasons
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Sex differences in glucose metabolism of streptozotocin-induced diabetes inbred mice (C57BL/6J) Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-22 Boyoung Kim; Yoo Yeon Kim; Phuong Thi-Thanh Nguyen; Hajin Nam; Jun Gyo Suh
Considering that sex differences in glucose metabolism are observed in mice, researchers unconsciously use male mice to reduce variations by an estrogen cycle in female mice. In this study, we investigated the sex differences in glucose homeostasis in streptozotocin (STZ)-induced diabetes inbred mice (C57BL/6J). The C57BL/6J male and female mice were injected with or without STZ (40 mg/kg) for 5 consecutive
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Protective effect of procyanidin B2 on hydrogen peroxide (H2O2)-induced oxidative damage in MCF-7 cells Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-21 Jia-qi Tan; Peng-cheng Li; Qian Li; Jin-tian Tang; Hong-kun Xue
The aim of this study is to assess the cytoprotection and potential molecular mechanisms of procyanidin B2 (PCB2) on hydrogen peroxide (H2O2)-induced oxidative damage in MCF-7 cells. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to determine the viability of MCF-7 cell exposure to H2O2 or PCB2. We measured the antioxidant properties of PCB2 by determining
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6-shogaol suppresses oxidative damage in L6 muscle cells Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-19 Jinyoung Hur; Yeonmi Lee; Chang Jun Lee; Ho-Young Park; Sang Yoon Choi
Ginger (Zingiber Officinale Roscoe) has been known reduce muscle pain after exercise, and 6-shogaol {(E)-1-(4-Hydroxy-3-methoxyphenyl)dec-4-en-3-one)} is the major essential oil contained in ginger. In this study, the protective effect of 6-shogaol on L6 muscle cells against oxidative damage was measured. 6-shagol inhibited the damage of L6 cell induced by H2O2, and allowed the increase in mRNA and
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Purification of high purity docosahexaenoic acid from Schizochytrium sp. SH103 using preparative-scale HPLC Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-16 Chi-Eun Oh; Gap-Jin Kim; Seung-Jin Park; Seunghoon Choi; Min-Joo Park; O-Mi Lee; Jeong-Woo Seo; Hong-Joo Son
High purity polyunsaturated fatty acids (> 95%) are essential for the synthesis of specialized pro-resolving lipid mediators (SPMs), such as protectins, resolvins, and maresins, which are used for clinical application. To date, high purity (> 95%) eicosapentaenoic acid (EPA; C20:5n3) and docosahexaenoic acid (DHA; C22:6n3) have been produced through various manufacturing steps using fish oil. In this
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Biosynthesis of fraxetin from three different substrates using engineered Escherichia coli Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-14 Seung Hoon An; Gyu-Sik Choi; Joong-Hoon Ahn
Fraxetin, which is a simple coumarin, is a phytochemical present in medicinal plants, such as Fraxinus rhynchophylla, and Cortex Fraxini. In plants, it serves as a controller of iron homeostasis. The health-enhancing activities of fraxetin, such as anticancer, neuroprotective and antibacterial activities, are known. Scopoletin 8-hydroxylase (S8H) is a key enzyme involved in the synthesis of fraxetin
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Glycolysis stimulation and storage protein accumulation are hallmarks of maize (Zea mays L.) grain filling Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-13 Jung-Tae Kim; Gibum Yi; Mi-Jung Kim; Beom-Young Son; Hwan-Hee Bae; Young Sam Go; Sun-Lim Kim; Seong-Bum Baek; Seung-Hyun Kim; Ill-Min Chung
Maize (Zea mays L.) is a major dietary source of human caloric intake. Grain filling, the developmental stage of the seed during which starch and proteins accumulate, is of great interest in plant biology and agronomy. However, proteomic datasets covering maize seed development, especially during grain filling, are much scarcer than transcriptomic datasets, largely due to the labor-intensive and costly
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Effect of sequential presoaking and chlorine dioxide treatment on the inactivation of pathogenic Escherichia coli and Salmonella spp. on sprout seeds Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-10 Nguyen Bao Hung; Woon-Ra Park; Bohyun Yun; Dong Cheol Seo; Won-Il Kim; Hyun-Ju Kim; Sanghyun Han; Se-Ri Kim
This study was conducted to evaluate the effect of sequential presoaking and chlorine dioxide (ClO2) on the reduction of pathogenic Escherichia coli and Salmonella spp. in alfalfa. When unsoaked and presoaked alfalfa were exposed to 200 ppm ClO2 for 15 min, the population of E. coli and Salmonella spp. on presoaked seeds reduced more than those on unsoaked seeds by 2.07 and 1.43 log CFU g−1 (p < 0
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Sorption of urea hydrogen peroxide by co-pyrolysed bone meal and cow dung slowed-down phosphorus and nitrogen releases but boosted agronomic efficiency Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-09 Deogratius Luyima; Jwakyung Sung; Jae-Han Lee; Seong-Ah Woo; Seong-Jin Park; Taek-Keun Oh
Co-pyrolysis of animal manure biomass with bone meal (BM) and soaking of the resultant biochar in urea containing solutions may offer a sustainable and cheap way of formulating slow-release nitrogen (N) and phosphorus (P) fertilisers. This method can lead to optimisation of the carbon sequestration capacity of the biochar, abatement of environmental pollution by P and N and alleviation of the severity
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Anti-inflammatory effect of unripe apple polyphenols-chitooligosaccharides microcapsule against LPS-induced RAW 264.7 cells Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-05 Hu-Zhe Zheng; Chun-Lan Cui; Woo-Sik Jeong; Shin-Kyo Chung
In order to improve the synergistic effect of unripe apple polyphenols (APP) and chitooligosaccharides (COS), apple polyphenols-chitooligosaccharides microcapsule (APCM) were prepared by spray-drying method. The effects of APCM on the release of polyphenols in simulated gastrointestinal digestion model, as well as the anti-inflammatory effect against LPS-induced RAW264.7 cells were also evaluated.
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Estimation of daily intake of lycopene, antioxidant contents and activities from tomatoes, watermelons, and their processed products in Korea Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-04 Hyunjeong Park; Young-Jun Kim; Youngjae Shin
Tomatoes, watermelons, and processed tomato products contain abundant antioxidant compounds, including lycopene. In spite of the interest in the role of lycopene, little is known about the contribution of tomatoes and tomato products commonly consumed in Korea to the intake of lycopene. In this study, the daily per capita intake values of lycopene and antioxidant compounds and activities of tomatoes
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Preventive effect of Lactobacillus plantarum HFY09 on HCl/ethanol-induced gastric injury in mice Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-09-03 Fang Li; Hailan Sun; Guangjun Ran; Xinhong Liu; Ruokun Yi; Fang Tan; Xin Zhao; Huazhi Liu
The aim of this study was to investigate the effect of Lactobacillus plantarum HFY09 on gastric injury induced by HCl/ethanol in Kunming mice. The results showed that HFY09-H inhibited any increases in gastric juice volume, maintained the normal pH value of gastric acid, and reduced the damage caused to the gastric mucosa and gastric wall, the inhibition rate on the injury area reaches 63.70%. Compared
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Effect of sodium silicate on early growth stages of wheat under drought stress Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-08-28 Sang Gyu Lee; Hyeri Lee; Byung Cheon Lee; Hojoung Lee; Jun Cheol Moon; Changhyun Choi; Namhyun Chung
Wheat yield is decreasing due to climate change, and a method to prevent decreasing yield during drought stress is desirable. In this study, wheat cultivars (Koso and Jokyung) were treated with 15% polyethylene glycol-6000 (PEG) and PEG + Si solution (6.5, 8.7, 13.1 and 26.1 mM). The effect of Si treatment on the alleviation of drought stress was measured using the germination test, shoot relative
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Detoxifying and antioxidant effect of ellagic acid nano particles in rats intoxicated with sodium nitrites Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-08-17 Amira Ragab EL Barky; Tarek Mostafa Mohamed; Ehab Mostafa Mohamed Ali
Sodium nitrite is used as a preservative in food products to stabilize color and reduce rancidity. Its absorption into the body causes many diseases. Ellagic acid is a natural polyphenol that contains powerful antioxidants, but it is taken as a poorly absorbed food. Therefore, chitosan-coated nanoparticles (EANP@CS) were loaded to enhance their bioactivity and bioavailability after oral administration
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Zerumbone attenuates lipopolysaccharide-induced activation of BV-2 microglial cells via NF-κB signaling Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-08-15 Min Ji Gu; Pyeongjae Lee; Sang Keun Ha; Jinyoung Hur
The brain is considered an immune-privileged organ. However, it has been found that inflammation mediated by microglia, which were once believed to support the brain structure, plays important roles in neuronal cell survival and death. Whether activated microglia has beneficial or detrimental effects on neurons remain controversial. Activated microglia could contribute to maintaining homeostasis in
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Effect of persimmon leaves (Diospyros kaki) on goblet cell density and inflammation in experimental dry eye model Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-08-13 Kyung-A Kim; Chung Hyun Lee; Tae Kyeom Kang; Sung Jae Yang; Chang Yong Lee; Wook-Bin Lee; Sang Hoon Jung
The efficacy of ethanol extract of Diospyros kaki (EEDK) on dry eye (DE) was determined using an experimental mouse model. Experimental groups included three treated with various amounts of EEDK and one treated with omega-3 for 2 weeks. Damage to the ocular surface was evaluated, and the presence of conjunctival goblet cells was determined. Moreover, the inflammatory response was analyzed via RT-PCR
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Bioleaching of Zn from sphalerite using Leptospirillum ferriphilum isolate: effect of temperature and kinetic aspects Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-08-09 Venkatesa Prabhu Sundramurthy; Baskar Rajoo; Natesan Rajendran Srinivasan; Rajan Kavitha
Biological methods for leaching of nonferrous and noble metals from its sulfide ores are widely applied at industrial enterprises of different countries. This process is based on the use of the oxidative activity of acidophilic microorganisms. Since all bio systems are quite sensitive to the temperature, bacterial leaching process also significantly effects. In the present study, the impact of temperature
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Protective effect of Lactobacillus plantarum ATCC8014 on acrylamide-induced oxidative damage in rats Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-08-06 Sijia Zhao; Xiaoduo Zhao; Qingbo Liu; Yujun Jiang; Yanhua Li; Wenxiao Feng; Honghua Xu; Meili Shao
Acrylamide (AA), which is mainly found in fried foods, causes neurotoxicity, genetic toxicity, carcinogenic effects, and DNA damage. This study confirms that a strain of lactic acid bacteria (Lactobacillus plantarum ATCC8014) could alleviate the toxicity of rats by inhibiting the AA-induced oxidative damage. Forty-eight adult male SD rats were randomly divided into eight groups: control group, AA group
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Heavy metal remediation in soil with chemical amendments and its impact on activity of antioxidant enzymes in Lettuce (Lactuca sativa) and soil enzymes Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-07-30 Young Kyu Hong; Jin Wook Kim; Sang Phil Lee; Jae E. Yang; Sung Chul Kim
Chemical amendments have been used to remediate soils contaminated with heavy metals. However, there is little understanding on the impacts of these amendments on the physiological and biochemical functions of plants and soil. This study used in situ microcosm experiment to understand the effect of chemical amendments on antioxidant and soil enzyme activity in plant and soil with respect to heavy metal
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Bromelia karatas and Bromelia pinguin: sources of plant proteases used for obtaining antioxidant hydrolysates from chicken and fish by-products Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-07-22 Martha Guillermina Romero-Garay; Emmanuel Martínez-Montaño; Adrián Hernández-Mendoza; Belinda Vallejo-Cordoba; Aarón Fernando González-Córdova; Efigenia Montalvo-González; María de Lourdes García-Magaña
In the present study, we evaluated new sources of plant proteases from fruits of Bromelia karatas (BK) and Bromelia pinguin (BP) to obtain antioxidant hydrolyzates/bioactive peptides (BPs) derived from chicken by-products (CH) and fish by-products (FH). The profile of the peptides was identified by reverse-phase high-resolution liquid chromatography (RP-HPLC) and the size weight distribution by molecular
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Characterization of a novel endolysin from bacteriophage infecting Vibrio parahaemolyticus, vB_VpaP_KF2 Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-07-21 Jeong-A Lim; Nari Lee; Hyang-Sook Chun; Hyun-Joo Chang
The antimicrobial resistance of food-borne pathogenic bacteria, including Vibrio parahaemolyticus, has been reported globally, warranting the need to identify promising alternative antibiotics such as endolysins that originate from bacteriophages. In our previous study, we characterized a bacteriophage infecting V. parahaemolyticus, vB_VpaP_KF2, at the molecular level. In this study, an open reading
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Dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis and their cytotoxicity on human cancer cell lines Appl. Biol. Chem. (IF 1.838) Pub Date : 2020-07-18 Sung-Kyu Choi; Yeong-Geun Lee; Rong Bo Wang; Hyoung-Geun Kim; Dahye Yoon; Dae-Young Lee; Yeon-Ju Kim; Nam-In Baek
Repeated chromatographic separations of the EtOAc fraction of Schisandra chinensis fruits on silica gel, octadecyl silica gel, and Sephadex LH-20 led to the isolation and identification of seven dibenzocyclooctadiene lignans (1–7). The NMR data reported in the literature for angeloyl gomisin H (5) were shown to be incorrect. We unambiguously identified the compounds based on detailed analysis of the
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