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Classification of soybeans from different habitats based on metabolomic–transcriptomic integration Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-03-16 Jinghui Wang, Qiyou Zheng, Chenxu Wang, Ao Zhou
Soybeans are a significant agricultural product in China, with certain geographical locations often yielding higher quality, and thus more expensive, soybean crops. In this study, metabolomics and transcriptomics analyses were conducted on soybean samples from nine regions in Heilongjiang and Liaoning Provinces using untargeted liquid chromatography–mass spectrometry (LC–MS) and Illumina sequencing
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Bioactive compounds from Withania somnifera dun and their toxicity against some piercing sucking pests Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-03-13 Amany Ragab, Mohamed A. Taher, Helmy H. El-Rafey, Ahmed Ramadan El-Rokh
Piercing sucking pests are destructive to many strategic crops all over the world. Botanical pesticides can be used to control these pests. A new withanolide derivative 3 named sominone A ((20R,22R)-1α,3β,20,27-tetrahydroxywitha-5,24-dienolide) was isolated from the alkaloid fraction of the whole plant of Withania somnifera. In addition, there are three known compounds named withasomine 1, methyl isoferulate
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Exploring the binding interactions of NOP receptor with designed natural phytochemical-neuropeptide conjugates: an in silico and SPR study Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-03-09 Molly E. Murray, Beatriz G. Goncalves, Mary A. Biggs, Sophia A. Frantzeskos, Charlotta G. Lebedenko, Ipsita A. Banerjee
The Nociceptin/orphanin FQ peptide (NOP) receptor is considered a member of the opioid receptor subfamily of G-protein coupled receptors (GPCRs) which has been shown to be present in many parts of the central nervous system (CNS). It plays biologically diverse roles in pain modulation, immune response and in neurodegenerative diseases. In this work, phytochemical conjugates of two known neuropeptides
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Ginsenosides as dietary supplements with immunomodulatory effects: a review Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-03-06 Ping Tang, Sitong Liu, Junshun Zhang, Zhiyi Ai, Yue Hu, Linlin Cui, Hongyang Zou, Xia Li, Yu Wang, Bo Nan, Yuhua Wang
Immune disorders have become one of the public health problems and imposes a serious economic and social burden worldwide. Ginsenosides, the main active constituents of ginseng, are regarded as a novel supplementary strategy for preventing and improving immune disorders and related diseases. This review summarized the recent research progress of ginsenosides in immunomodulation and proposed future
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Optimized protocols for protoplast isolation, transfection, and regeneration in the Solanum genus for the CRISPR/Cas-mediated transgene-free genome editing Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-03-05 So Hee Yang, Suk Weon Kim, Sujin Lee, Yeonjong Koo
The Solanaceae family includes the largest flowering crops such as tomatoes, potatoes, and eggplants. Consumer demand has led to massive development of plants in the Solanum genus, and many different Solanum varieties are now available on the market. The recent advances in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-based genome editing have
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Pannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-03-01 Jong Min Oh, Qian Gao, Woong-Hee Shin, Eun-Young Lee, Dawoon Chung, Grace Choi, Sang-Jip Nam, Hoon Kim
Six compounds were isolated from Penicillium sp. SG-W3, a marine-derived fungus, and their inhibitory activities against target enzymes relating to neurological diseases were evaluated. Compound 1 (pannorin) was a potent and selective monoamine oxidase (MAO)-A inhibitor with a 50% inhibitory concentration (IC50) of 1.734 μM and a selectivity index (SI) of > 23.07 versus MAO-B, and it showed an efficient
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Potentials of 3D printing in nutritional and textural customization of personalized food for elderly with dysphagia Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-29 Chhychhy Chao, Hyong Kyong Nam, Hyun Jin Park, Hyun Woo Kim
Elderly individuals commonly experience the risk of dysphagia or difficulties in eating and swallowing food safely. Three-dimensional (3D) food printing is a promising technique widely used in customized food development. This paper reviewed the potential of 3D food printing in nutritional customization and textural modification of personalized food for the elderly with dysphagia. 3D food printing
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Curcuma longa L. extract increased immune responses in RAW 264.7 cells and cyclophosphamide-induced BALB/c mice Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-28 Se Jeong Kim, San Kim, Sehyeon Jang, Da Hye Gu, Jeong Min Park, Jung A. Ryu, Sung Ran Yoon, Sung Keun Jung
Curcuma longa L. extract (CLE) exerts various biological functions including antioxidant, anti-inflammation, anticancer, and antiallergenic effects. However, its immune-enhancing capacity remains unclear. Therefore, the immune-enhancing effect of CLE was investigated in RAW 264.7 cells and cyclophosphamide (CPP)-induced immunosuppression model. CLE upregulated nitric oxide (NO) and reactive oxygen
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Development of fermented beverage with citrus fruit extract using probiotics: impact on antioxidant activity and in vitro digestibility Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-28 Doyoung Kim, Imkyung Oh
Redhyang (Citrus hybrid ‘Kanpei’,CHK) is a subtropical citrus species introduced in Korea due to climate change. To enhance the nutritional value and usability of CHK as a processed food product, CHK extract was fermented with four types of commercial starters (YoFlex Harmony 1.0 (YFH), ABY-3 (ABY), YC-X11 (YXC), and YC-180 (YC)), and their antioxidant activities and changes in chemical properties
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Yield, functional properties and nutritional compositions of leafy vegetables with dehydrated food waste and spent coffee grounds Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-27 Young-Ji Jeon, Yun-Gu Kang, Jin-Ah Eun, Taek-Keun Oh
This study determined the fertilizer potentials of the dehydrated food waste powder (DFWP) and spent coffee grounds (SCGs) through assessing their effects on yield, antioxidant activities, mineral and proximate compositions of leaf lettuce and Japanese hogfennel their efficiencies to inorganic fertilizers (N-P2O5-K2O, NPK). In this study, both organic amendments were applied at rates that supplied
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Soybean flower-specific R2R3-MYB transcription factor gene GmMYB108 induces anthocyanin production in Arabidopsis thaliana Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-24 Ju Yeon Moon, Saet Buyl Lee, Yu Jeong Jeong, Gah-Hyun Lim, Gilok Shin, Man-Soo Choi, Jeong Ho Kim, Ki Hun Park, Jiyoung Lee, Jae Cheol Jeong, Cha Young Kim
R2R3-MYB transcription factors (TFs) are known to play a key role in regulating the expression of structural genes involved in plant flavonoid biosynthesis. However, the regulatory networks and related genes controlling isoflavonoid biosynthesis in soybean are poorly understood. We previously reported that ethephon application increases the production of isoflavonoids in soybean leaves. In this study
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Antioxidant and anti-inflammatory activities of the methanol extract from the bran of the colored wheat, 'Ariheuk' Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-23 Seung-Gyeom Kim, So-Hyeon Park, Joong-Hyuck Auh
In vitro antioxidant and anti-inflammatory activities were investigated using a 70% acidic methanol extract of the colored wheat bran, 'Ariheuk.' Active metabolites were identified via metabolomic analysis using multivariate statistical comparisons. The 'Ariheuk' bran extract (ABE) contained a higher total anthocyanin content (0.19 mg C3G/g) than the general wheat bran extract (GBE) (0.01 mg C3G/g)
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Comprehensive in vitro and in vivo investigations of the therapeutic potential of Jeju lava seawater salt in osteoarthritis Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-22 Mangeun Kim, Min Hye Kim, Jinho Kim, Kyungpil Kang, Junsu Lee, Mrinmoy Ghosh, Young-Ok Son
Salts play a crucial role in maintaining human health by regulating fluid levels and supporting various physiological processes. However, conventional seawater-derived salts are associated with microplastic pollution and pose potential health risks. Jeju lava seawater (JLS), sourced exclusively from Jeju Island, has emerged as a unique alternative, free of microplastics and enriched with essential
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Antioxidant activity of different cultivars of Chrysanthemum morifolium and quantitative analysis of phenolic compounds by HPLC/UV Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-21 Tham Thi Mong Doan, Gia Han Tran, Toan Khac Nguyen, Jin Hee Lim, Sanghyun Lee
Chrysanthemum morifolium is classified within the Asteraceae botanical family and serves as a phytomedicine in many countries. The objective of this study was to quantitatively analyze twelve phenolic compounds through HPLC/UV and to assess the antioxidant abilities using the DPPH and ABTS+ assays in the leaves and flowers of six cultivars of C. morifolium: ‘Geumsu’, ‘Ilonka’, ‘Silvia’, ‘Pompadour’
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Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-15 Minji Kim, Jangeun An, Seong-Ah Shin, Sun Young Moon, Moonsu Kim, Seyeon Choi, Huiji Kim, Kim-Hoa Phi, Jun Hyuck Lee, Ui Joung Youn, Hyun Ho Park, Chang Sup Lee
Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral
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Distribution of microplastics in soil by types of land use in metropolitan area of Seoul Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-14 Jung-Hwan Yoon, Bo-Hyun Kim, Kye-Hoon Kim
Plastic pollution is becoming a significant problem in urban areas due to excessive use and careless disposal. While studies on microplastics are increasingly being conducted across various environments, research on microplastics in soil is limited compared to other areas. Microplastics entering the soil through various routes can stay there for a long period of time, threatening soil organisms and
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Correction: Impact of biochar and compost amendment on corn yield and greenhouse gas emissions under waterlogged conditions Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-13 Han-Na Cho, Minji Shin, Ikhyeong Lee, Haeun Ryoo, Bharat Sharma Acharya, Jae-Hyuk Park, Yong Hwa Cheong, Ju-Sik Cho, Se-Won Kang
Correction: Applied Biological Chemistry (2023) 66:87 https://doi.org/10.1186/s13765-023-00845-8 Following publication of the original article [1], the authors would like to correct the errors occurred in Fig. 1, Table 1, Materials and Methods, and Results section. Fig. 1 Mean air temperature (a) and total precipitation (b) during corn’s seasonFull size image The corrected sentences and the correct
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Simultaneous determination of 31 Sulfonamide residues in various livestock matrices using liquid chromatography-tandem mass spectrometry Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-09 Yu Ra Kim, Sunyoung Park, Ji Young Kim, Jang-Duck Choi, Gui-Im Moon
The widespread use of sulfonamides can result in the residue of sulfonamides in the foods of animal origin that are the major concerns of consumers and regulatory bodies due to their adverse reaction such as the development of antibiotic resistance. A rapid and efficient multi-residue analytical method was developed to screen and confirm 31 sulfonamides in livestock samples in a single run, using
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Simultaneous determination of sulfonylurea herbicides in tomatoes using the QuEChERS method coupled with HPLC Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-05 Sang Gyu Han, Tae Gyu Nam
The simultaneous determination of trace pesticides in complex matrices containing high concentrations of natural pigments remains challenging. In this study, quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation together with high-performance liquid chromatography with ultraviolet detection (HPLC–UV) was applied for the multi-residue analysis of seven sulfonylurea herbicides
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Correction: Acute neuro-biochemical changes induced by nitrogen-tungsten co-doped titanium dioxide nanoparticles Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-02-05 Hafz Muhammad Umer Farooqi, Jooho Lee, Cheong-Ah Lee, Seung-Uk Im, Muhammad Awais Farooqi, Tasbiha Gul, Ghayas Uddin Siddiqui, Dong-Guk Paeng
Correction: Applied Biological Chemistry (2023) 66:83 https://doi.org/10.1186/s13765-023-00836-9 Following publication of the original article [1], the authors identified an error in the author’s name of Jooho LEE. The incorrect author name is: Johoo Lee. The correct author name is: Jooho Lee. The author group has been updated above and the original article [1] has been corrected. Farooqi HM, Lee J
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High-iron consumption decreases copper accumulation and colon length, and alters serum lipids Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-31 Jisu Lee, Hyun-Joo Lee, Hyunsoo Jang, Jae-Joon Lee, Jung-Heun Ha
In this study, we aimed to demonstrate that a significant increase in dietary iron intake disrupts the regulation of copper availability, ultimately leading to systemic copper deficiency. To investigate this, we conducted experiments using five-week-old male weanling Sprague–Dawley rats fed diets based on AIN-93G with some modifications. These diets featured varying iron content, offering choices of
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Potential anti-acne loaded nanogel formulations of Origanum majorana L. and Chrysanthemum morifolium Ramat. essential oils Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-25 Eman A. Kotb, Riham A. El-Shiekh, Mariam Hassan, Wessam Hamdy Abd-Elsalam, Nebal El Tanbouly, Amira Safwat El Senousy
Acne is a highly prevalent skin disease with a great psychological impact on patients as self-perception, self-confidence, and depression. This work aimed to develop an anti-acne preparation from active anti-bacterial medicinal plants to circumvent the severe side effects and drug resistance commonly reported with topical erythromycin anti-acne preparations. Essential oils: Salvia officinalis L. (sage)
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Sulforaphane (Sul) reduces renal interstitial fibrosis (RIF) by controlling the inflammation and TGF-β/Smad signaling pathway Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-24 Ziqing Yu, Wen He, Weiwu Shi
All chronic renal disorders eventually lead to renal interstitial fibrosis (RIF). Chronic inflammation and pro-fibrotic substances are familiar companions of the fibrotic process. The Sulforaphane (Sul) molecule is particularly useful in protecting the liver from oxidative damage. To investigate the Sul effects on fibrosis markers and inflammatory proteins in the kidney of NRK52E cell line and rats
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Cow milk derived-fat inhibits the proliferation of liver cancer-cells Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-23 Meran Keshawa Ediriweera, Do Manh Cuong, Somi Kim Cho
Cow milk is a widely consumed liquid diet, and its fatty acid composition impacts its nutritional and biochemical properties. However, research on the anticancer efficacy of cow milk-derived fat in liver cancer cells is limited. This study investigated the antiproliferative and apoptotic effects of cow milk-derived fat in human hepatoma HepG2 cells. Additionally, the effects of cow milk-derived fat
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Development of morpholine ring-bearing halogenated α,β-unsaturated ketones as selective monoamine oxidase-B inhibitors Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-22 Jiseong Lee, Saranya Kattil Parmbil, Nagendar Kumar Pandit, Sunil Kumar, Asad Syed, Abdallah M. Elgorban, Ling Shing Wong, Ranjana, Hoon Kim, Bijo Mathew
Nine morpholine-derived halogenated chalcone derivatives (MHC1-MHC9) were synthesized, and their inhibitory activity against monoamine oxidase (MAO) was evaluated. MHC5 showed the highest inhibitory activity against MAO-B with an IC50 value of 0.065 μM, followed by MHC7 (IC50 = 0.078 μM) and MHC6 (IC50 = 0.082 μM). The para-F substituent MHC4 was also potent (IC50 = 0.095 μM). The selectivity index
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Bioactive compounds and antioxidant activity in three types of Korean watery kimchi Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-18 Hyosun Park, Suna Kim, Jaecheol Kim, KyeongJin Lee, BoKyung Moon
Watery kimchi is a traditional fermented food served with its soup. In this study, we collected 21 samples of yeolmu mul kimchi (YMK), dongchimi (DC), and nabak kimchi (NK), respectively, which are the most popular watery kimchi in Korea. A composite sample of each watery kimchi was prepared for estimation of their bioactive compounds and antioxidant activities. Of the three kimchi types, YMK had the
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Biochemical characterization of a regiospecific flavonoid 3'-O-methyltransferase from orange Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-11 Hye Lin Park, Seong Hee Bhoo, Sang-Won Lee, Man-Ho Cho
Citrus plants have diverse methoxyflavonoids including, chrysoeriol, isosakuranetin, and nobiletin. In plants, O-methyltransferases (OMTs) participate in the methylation of a vast array of secondary metabolites, including flavonoids, phenylpropanoids, and alkaloids. To identify functional OMTs involved in the formation of methoxyflavonoids, orange (Citrus sinensis) OMT (CsOMT) genes were retrieved
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Contrasting effects of food waste and its biochar on soil properties and lettuce growth in a microplastic-contaminated soil Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-10 Kumuduni Niroshika Palansooriya, Piumi Amasha Withana, Yoonah Jeong, Mee Kyung Sang, Yoora Cho, Geonwook Hwang, Scott X. Chang, Yong Sik Ok
The incorporation of organic amendments, such as food waste (FW) and biochar, into soil is an established agronomic practice known for enhancing soil fertility and improving overall soil health. However, the individual and combined effects of FW and biochar on soil properties in microplastic (MP)-contaminated soil–plant systems remain poorly understood. To address this knowledge gap, we conducted a
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Non-thermal plasma enhances rice seed germination, seedling development, and root growth under low-temperature stress Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-03 Jing-Yang Bian, Xiao-Yu Guo, Dong Hun Lee, Xing-Rong Sun, Lin-Shuai Liu, Kai Shao, Kai Liu, Hu-Nan Sun, Taeho Kwon
Recently, non-thermal plasma (NTP) technologies have found widespread application across diverse fields, including plant growth, medical science, and biological and environmental research. Rice (Oryza sativa L.) is exceptionally sensitive to temperature changes. Notably, low-temperature stress primarily affects the germination and reproductive stages of rice, often leading to reduced crop yield. This
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Monitoring of soil EC for the prediction of soil nutrient regime under different soil water and organic matter contents Appl. Biol. Chem. (IF 3.2) Pub Date : 2024-01-03 Han Na Kim, Jin Hee Park
Smart farms and precision agriculture require automatic monitoring and supply of water and nutrients for crops, but sensors to monitor plant available nutrients in soil are not available. Soil electrical conductivity (EC) is related to nutrients in soil solution, which can be affected by soil organic matter, soil texture, temperature, and water content. Therefore, the objective of this study is to
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Heterologous expression in E. coli and functional characterization of the tomato CPR enzymes Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-12-19 Won Choi, Seo Young Park, Hyun Min Kim, Thanh Dat Mai, Ju Hui Do, Hye Min Jang, Hyeon Bae Hwang, Eun Gyeong Song, Jae Sung Shim, Young Hee Joung
NADPH-cytochrome P450 reductase (CPR) is a key enzyme transferring electrons to cytochrome P450. In tomatoes (Solanum lycopersicum), two CPR genes, SlCPR1 and SlCPR2, were identified. In all the tested tomato tissues, SlCPR2 showed higher expression levels than SlCPR1. SlCPR2 expression increased significantly with jasmonic acid treatment. No significant changes were observed with salicylic acid or
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Reduction of ammonia gas by microbial agent treatment in Chinese cabbage cultivation Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-12-16 Jong-Hwan Park, Su-Lim Lee, Jae-Hoon Lee, Jun-Suk Rho, Jeong-Min Lee, Seong-Heon Kim, Se-Won Kang, Dong-Cheol Seo
This study aimed to select the optimal microbial agents for ammonia gas reduction in Chinese cabbage cultivation and evaluate their ammonia reduction efficiency. By selecting the optimum microorganism to reduce ammonia emissions, the ammonia emission reduction efficiencies of the nitrification microorganisms, Alcaligenes faecalis subsp. faecalis and Brevibacillus sp. were 21 and 31%, respectively,
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Synergistic impact of autocrine motility factor and curcumin on colorectal cancer cell proliferation Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-12-15 Seok Joong Kim, Yangji Kim, Thanh Van Duong, Hee Sung Park
Colorectal cancer (CRC) presents a formidable challenge, characterized by a steadily increasing incidence. Current approaches to manage CRC, including chemotherapy and targeted therapies, are burdened with significant limitations such as resistance development, adverse events, and high costs. Hence, there is an urgent demand for a more promising alternative. Autocrine motility factor (AMF), known for
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Recent progress on drugs discovery study for treatment of COVID-19: repurposing existing drugs and current natural bioactive molecules Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-12-13 Ika Oktavianawati, Mardi Santoso, Mohd Fadzelly Abu Bakar, Yong-Ung Kim, Sri Fatmawati
COVID-19 has been a major global health concern for the past three years, and currently we are still experiencing coronavirus patients in the following years. The virus, known as SARS-CoV-2, shares a similar genomic identity with previous viruses such as SARS-CoV and MERS-CoV. To combat the pandemic, modern drugs discovery techniques such as in silico experiments for docking and virtual screening have
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Centella asiatica lowers body fat accumulation via regulating cholesterol homeostasis- and lipid metabolism-related genes in mice with high-fat, high-sugar diet-induced obesity Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-12-10 Yeok Boo Chang, Yejin Ahn, Daebang Seo, Soohyun Bae, Hyung Joo Suh, Yang Hee Hong, Eun Young Jung
To understand the mechanisms involved in the anti-obesity effects Centella asiatica (CA), we examined body weight, serum levels, white adipose tissue (WAT) weight, histological analysis, and the expression of cholesterol homeostasis- and lipid metabolism-related genes in mice with high-fat, high-sugar diet (HFHSD)-induced obesity that were orally treated with CA for 12 weeks. Eight-week-old, male C57BL/6J
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Impact of biochar and compost amendment on corn yield and greenhouse gas emissions under waterlogged conditions Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-12-07 Han-Na Cho, Minji Shin, Ikhyeong Lee, Haeun Ryoo, Bharat Sharma Acharya, Jae-Hyuk Park, Yong Hwa Cheong, Ju-Sik Cho, Se-Won Kang
Biochar, widely recognized for its capacity to counteract climate change impacts, has demonstrated substantial benefits in agricultural ecosystems. Nevertheless, empirical studies exploring its efficacy during climatic aberrations such as heavy rainfall are limited. This study investigated the effects of compost and biochar addition on corn growth attributes, yield, and soil CO2 and N2O fluxes under
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Metabolic Evidence on Vintage Effect in Tea (Camellia sinensis L.) Plants Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-12-06 N. H. M. Rubel Mozumder, Kyeong Hwan Hwang, Min-Seuk Lee, Eun-Hee Kim, Young-Shick Hong
Recent metabolomics studies have reported diverse metabolites of tea depending on tea (Camellia sinensis) cultivars, cultivation conditions and geographical location. However, these studies were limited the effects of these conditions on metabolome of tea leaves in a single year. We explored the year-to-year variations in leaf metabolome of two tea (C. sinensis) cultivars over a period of five successive
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The ginsenoside Rg2 downregulates MMP-1 expression in keratinocyte (HaCaT)-conditioned medium-treated human fibroblasts (Hs68) Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-12-06 Sol-ra Oh, Se-keun Park, Pyeongjae Lee, Yong-Min Kim
Keratinocytes exposed to UVB induce the production of cytokines, which activate fibroblasts and increase the expression of matrix metalloproteinases (MMPs). The increased expression of MMPs leads to connective tissue damage and wrinkle formation, resulting in skin aging. In this study, we used human dermal fibroblasts cultured in UVB-irradiated keratinocyte-conditioned medium (UV CM) to investigate
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Hypothetical protein CuvA (Rv1422) from Mycobacterium tuberculosis H37Rv interacts with uridine diphosphate N-acetylglucosamine as a key precursor of cell wall Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-25 Yoon Chae Jeong, Jihyun Park, Yu Jeong Cheon, Ki Seog Lee
Mycobacterium tuberculosis CuvA (Rv1422, MtCuvA) has previously been suggested that it may play a critical role in nutrient utilization and cell wall synthesis required for physiological adaptation in a host cell, but its biochemical details remain unclear. Our previous studies showed that MtCuvA can bind to uridine diphosphate (UDP) sugars as a cell wall precursor component. To verify its functional
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Acute neuro-biochemical changes induced by nitrogen-tungsten co-doped titanium dioxide nanoparticles Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-24 Hafiz Muhammad Umer Farooqi, Johoo Lee, Cheong-Ah Lee, Seung-Uk Im, Muhammad Awais Farooqi, Tasbiha Gul, Ghayas Uddin Siddiqui, Dong-Guk Paeng
Nitrogen-tungsten co-doped titanium dioxide nanoparticles (W-N-doped TiO2 NPs) are employed for the photocatalytic degradation of environmental pollutants. However, the potential impact of these nanoparticles on the central nervous system remains a subject of concern. This study aimed to evaluate the effects of W-N-doped TiO2 NPs on neurophysiological and biochemical parameters of healthy rat brains
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Metabolomics reveals that Curcuma longa and demethoxycurcumin inhibit HCT116 human colon cancer cell growth Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-24 Dahye Yoon, Bo-Ram Choi, Woo Cheol Shin, Kwan-Woo Kim, Young-Seob Lee, Dae Young Lee
Studies on the use of natural products to treat cancer are ongoing, and turmeric (Curcuma longa L.), a medicinal crop, is known for various effects including anticancer activity. In this study, the inhibitory effect of C. longa and demethoxycurcumin on cancer cell growth in a colorectal cancer cell line (HCT116) was investigated by using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics
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Pleiotropic properties of GOLDEN2-LIKE transcription factors for crop improvement Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-23 Sangyun Kim, Heebak Choi, Taegyu Yi, Dohoon Gwak, Sun-Hwa Ha
Crop improvement can be affected by enhancing the efficiency of photosynthesis-associated bioprocesses such as chlorophyll biosynthesis, chloroplast biogenesis, the functioning of photosystems including light-harvesting complexes, and carbon fixation. To achieve this, the GOLDEN2-LIKE (GLK) transcription factors represent promising targets since they play a positive role for greening traits in diverse
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Green ultrasound-assisted extraction of fish oil from rainbow trout intestines and purification with adsorbents Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-22 Thu Thi Hoai Mai, Youngjoo Choi, Hanbyul Park, Jae Lyoung Cheon, Jae-Seok Choi, Donghwan Park, Hekap Kim
This study explored the application of green ultrasound-assisted technology for the extraction of oil from the intestines of rainbow trout. Purification methodologies were incorporated using adsorbents in order to enhance the quality of the extracted oil, which was evaluated based on its color, peroxide value (POV), free fatty acids, organic pollutants, and fatty acid composition. The extraction condition
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Inhibitory potential of rutin and rutin nano-crystals against Helicobacter pylori, colon cancer, hemolysis and Butyrylcholinesterase in vitro and in silico Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-17 Husam Qanash, Aisha M. H. Al-Rajhi, Majed N. Almashjary, Ammar A. Basabrain, Mohannad S. Hazzazi, Tarek M. Abdelghany
Despite the vital activity of many compounds, they lack that effectiveness due to their low solubility in water. Unfortunately, for this reason, rutin often leads to low tissue permeability and insufficient bioavailability, which has greatly limited its pharmacological utility. Therefore, the present investigation is designed to overcome this problem by formulating the rotin to rotin nanocrystals (RNCs)
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DB3 from Antarctic lichen inhibits the growth of B16F10 melanoma cells in vitro and in vivo Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-15 Seyeon Choi, Huiji Kim, Seong-Ah Shin, Moonsu Kim, Sun Young Moon, Minji Kim, Seulah Lee, Jun Hyuck Lee, Hyun Ho Park, Ui Joung Youn, Chang Sup Lee
Malignant melanoma is a fatal disease with an increasing global incidence. Despite numerous studies focused on anti-cancer drugs, a variety of side effects of cancer treatment remain challenging. Thus, there is a pressing need to identify novel anti-cancer agents with minimal cytotoxicity and side effects. DB3 (1,3,7,9-tetrahydroxy-2,8-dimethyl-4,6-di[ethanoyl]dibenzofuran) is a member of the dibenzofuran
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Biosorption potential of Purpureocillium lilacinum biomass for chromium (VI) removal: isolation, characterization, and significance of growth limiting factors Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-14 Gizachew Assefa Kerga, Nurelegne Tefera Shibeshi, Sundramurthy Venkatesa Prabhu, Venkatramanan Varadharajan, Alazar Yeshitla
Chromium (VI) is known to be harmful element that commonly found industrial waste, mining activities, and wastewater discharges from various industries. When released into the environment, Cr (VI) can contaminate soil, water, and air, posing a serious threat to living organisms. Aiming to Cr decontamination, this work was framed to isolate the fungal species having high Cr tolerance capacity and to
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SARS-CoV-2 main protease inhibitors from the stem barks of Discoglypremna caloneura (Pax) Prain (Euphorbiaceae) and Pterocarpus erinaceus Poir (Fabaceae) and their molecular docking investigation Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-04 Paul Toukam Djouonzo, Md Sofequl Islam Mukim, Pamela Nangmo Kemda, Theodora Kopa Kowa, Alembert Tiabou Tchinda, Gabriel Agbor Agbor, Cheol-Ho Pan, Dae-Geun Song
The main viral protease (Mpro) of SARS-CoV-2 provides an excellent target for antivirals, due to its essential and conserved function in the viral replication cycle. We reported in this study, the SARS-CoV-2 main protease inhibitory effect of twelve compounds isolated from D. caloneura and P. erinaceus together with four derivatives. Among the effectively tested samples, two derivatized compounds displayed
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Asimina triloba (pawpaw) fruit extract suppresses adipocyte differentiation and lipogenesis-related protein expression in 3T3-L1 cells Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-11-02 Chang Jun Lee, Young-Soo Kim, Jinyoung Hur, Guijae Yoo, Sang Yoon Choi
Obesity is a health condition accompanied by life-threatening comorbidities; hence, there is an increasing need for anti-obesity agents. The anti-cancer effects of the leaves of Asimina triloba (pawpaw) has been reported. However, limited research has been conducted on the potential anti-obesity effects of A. triloba fruit. Therefore, this study aimed to explore the effects of A. triloba fruit extract
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Correction: In vitro repress of breast cancer by bio‑product of edible Pleurotus ostreatus loaded with chitosan nanoparticles Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-10-30 Aisha M. H. Al‑Rajhi, Tarek M. Abdel Ghany
Correction: Applied Biological Chemistry (2023) 66:33 https://doi.org/10.1186/s13765-023-00788-0 The Projects number in the Acknowledgment and Funding sections were incorrect in the original publication [1]. The correct information is given below: Incorrect project number: RI-44-0141 Correct project number: WE-44-002 The original article has been corrected. Al-Rajhi AM, Ghany TMA (2023) In vitro repress
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Evaluation of obesity prevention effect of black ginseng on serum, liver, and hypothalamus of mice on a high-fat diet using a metabolomics approach Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-10-28 Ye Jin Kim, Dae Young Lee, Hye Rim Yang, Kyung-Hoan Im, Sang Un Park, Jae Geun Kim, Jae Kwang Kim
Black ginseng is being studied to prevent obesity caused by a high-fat diet (HFD). The aim of this study was to evaluate the obesity-preventing effect of black ginseng extract (BGE) in the serum, liver, and hypothalamus of mice on an HFD using metabolomic techniques. Mice were divided into four groups which were respectively fed a normal diet (CTL), an HFD, an HFD with a low concentration of BGE (BGEL)
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Effect of co-presence of cadmium or procymidone with microplastic films in soil on lettuce growth Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-10-25 Eun Hea Jho, Ji Won Yang, Won Jung Ju, Sung-Jong Lee, Md Mehedee Hasan
Agricultural environment is often contaminated with various chemicals (e.g., pesticides, heavy metals) and microplastics due to the uses of plastic products. The effects of chemical contaminants or microplastics on terrestrial environment have been extensively studied, but the studies on the co-presence of chemical contaminants and microplastics are relatively limited. This study was set to investigate
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Correction: Optimisation of culture conditions for gesho (Rhamnus prinoides.L) callus differentiation using Artificial Neural Network-Genetic Algorithm (ANN-GA) Techniques Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-10-25 Minilu Dejene, Hemalatha Palanivel, Heeravathi Senthamarai, Venkatramanan Varadharajan, S. Venkatesa Prabhu, Alazar Yeshitila, Solomon Benor, Shipra Shah
Correction: Applied Biological Chemistry (2023) 66:64 https://doi.org/10.1186/s13765-023-00816-z In this article the author name Hemalatha Palanivel was incorrectly written as Hemalatha Palnivel. The original article [1] has been corrected. Dejene M, Palanivel H, Senthamarai H, Varadharajan V, Prabhu SV, Yeshitila A, Benor S, Shah S (2023) Optimisation of culture conditions for gesho (Rhamnus prinoides
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Challenging treatment of food wastes for cleaner production after the African swine fever outbreak in South Korea Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-10-14 Heesung Moon, Junhwa Kwon, Jeongwoo Choi, Dongjin Lee, Dong Cheol Seo
Food waste is a growing global concern, necessitating effective treatment solutions. South Korea stands out with over 90% of its food waste being recycled, driven by robust resource circulation policies. Across Asia, anaerobic digestion processes are favored for food waste treatment due to their economic and environmental advantages. The South Korean Government aims to expand anaerobic digestion to
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Development of multi-target dsRNAs targeting PcNLP gene family to suppress Phytophthora capsici infection in Nicotiana benthamiana Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-10-13 Minsu Park, Yujin Kweon, Jihyun Eom, Minsun Oh, Chanseok Shin
Phytophthora capsici, which causes diseases in solanaceous crops, secretes necrosis and ethylene-inducing peptide 1-like proteins (NLPs) that induce plant defense responses and leaf necrosis. In this study, we used RNA interference (RNAi) technique, a proven strategy for crop protection and gene regulation in plants, to suppress P. capsici infection through the inhibition of PcNLPs. In the RNAi mechanism
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Regulation of appetite-related neuropeptides by herbal medicines: research using microarray and network pharmacology Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-10-12 Ji Hwan Lee, Dongyeop Jang, Myong Jin Lee, Myoung-Sook Shin, Chang-Eop Kim, Jun Yeon Park, Ki Sung Kang
Anorexia means loss of appetite and is a state whereby a desire to eat is either reduced or eliminated resulting in reducing or stopping food intake. Sipjeondaebo-tang (SDT) and Hyangsayukgunja-tang (HYT) are prescriptions known to have appetite-improving effects, but studies on their mechanisms and active components are insufficient. The hypothalamus is the center of appetite control, and various
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Aryl sulfoxide scaffold useful as herbicide Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-10-05 Heeeun Kim, Inseoung Hwang, Sungbock Ryu, Keedon Han, Yonghoon Kwon
The escalating demand for effective and sustainable weed management strategies, driven by urbanization expansion, is a critical challenge. Herbicides are pivotal tools in modern agriculture, addressing this challenge. Developing novel herbicides with enhanced efficacy and minimal environmental impact is crucial for food security and ecological balance. While numerous herbicides have been developed
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Inhibitions of monoamine oxidases by ferulic acid hydrazide derivatives: synthesis, biochemistry, and computational evaluation Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-10-05 Arshida Thottile Peedikayil, Jiseong Lee, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed E. Shaker, Samy Selim, Sunil Kumar, Sanal Dev, Hoon Kim, Bijo Mathew
Monoamine oxidases (MAOs) regulate neurotransmitters, and changes in their regulation lead to neurogenerative diseases (NDs). Therefore, MAO inhibitors are used to treat NDs. Ferulic acid, a phenolic compound found in various plant species, has been demonstrated to have a variety of biological functions, including anti-inflammatory, anticancer, and neuroprotective effects. In this study, ten ferulic
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Wheat seedling extract and its constituents attenuate RANKL-induced differentiation and fusion of osteoclasts and bone resorption Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-09-26 HanGyeol Lee, Ji-Yeong Yang, Shin-Hye Kim, So-An Lim, Jae Kwang Kim, Chon-Sik Kang, Kyeong-Hoon Kim, Sik-Won Choi, Woo Duck Seo
The occurrence of osteoporosis gradually increases within the aging population. As the side effects of therapeutic agents currently used for osteoporosis are increasing, the development of preventive and therapeutic agents derived from natural products without any long-term side effects is important. Here, we investigated the effect of wheat seedling extract (WSE) on the RANKL-mediated differentiation
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Optimisation of culture conditions for gesho (Rhamnus prinoides.L) callus differentiation using Artificial Neural Network-Genetic Algorithm (ANN-GA) Techniques Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-09-24 Minilu Dejene, Hemalatha Palnivel, Heeravathi Senthamarai, Venkatramanan Varadharajan, S. Venkatesa Prabhu, Alazar Yeshitila, Solomon Benor, Shipra Shah
Gesho (Rhamnus prinoides) is a medicinal plant with antioxidant and anti-inflammatory activities commonly used in the ethnomedicinal systems of Africa. Using a three-layer neural network, four culture conditions viz., concentration of agar, duration of light exposure, temperature of culture, and relative humidity were used to calculate the callus differentiation rate of gesho. With the ability to quickly
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Effect of pH and temperature on the biodegradation of oxytetracycline, streptomycin, and validamycin A in soil Appl. Biol. Chem. (IF 3.2) Pub Date : 2023-09-23 Seon Hui Kim, So Yun Park, Ga Eun Kim, Eun Hea Jho
Residual antibiotics in agricultural soils can be of concern due to the development of antibiotic resistant microorganisms. Among various antibiotics, oxytetracycline (OTC), streptomycin (ST), and validamycin A (VA) have been used for agricultural purposes in South Korea; however, studies on the biodegradation of these antibiotics in soil are limited. Therefore, this study investigated the effects