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Diminished substrate‐mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats IUBMB Life (IF 3.244) Pub Date : 2021-01-22 Sasikala Rajendran Raji; Ravikumar Jayakumari Nandini; Sivasailam Ashok; Reghuvaran Chellappan Anand; Pillai Velayudhan Vivek; Jayakumar Karunakaran; Harikrishnan Vijayakumar Sreelatha; Shankarappa Manjunatha; Srinivas Gopala
Heart diseases are common in offspring of gestational diabetic mother (ODM). Defects in mitochondrial metabolism and autophagy may be one of the basic reasons behind the abnormal structural and functional behaviour of offspring’s heart. So the main objective of the present study was to explore the cardiac mitochondrial respiration and autophagy in male and female offspring of diabetic pregnancy at
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Diminished substrate‐mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats IUBMB Life (IF 3.244) Pub Date : 2021-01-22 Raji Sasikala Rajendran; Nandini Ravikumar Jayakumari; Ashok Sivasailam; Anand Chellappan Reghuvaran; Vivek Velayudhan Pillai; Jayakumar Karunakaran; Harikrishnan Vijayakumar Sreelatha; Shankarappa Manjunatha; Srinivas Gopala
Heart diseases are common in the offspring of gestational diabetic mother (ODM). Defects in mitochondrial metabolism and autophagy may, in part, be responsible for the adverse structural and functional alterations in the heart. The principal objective of this study was to investigate cardiac mitochondrial respiration and autophagy in male and female offspring of diabetic pregnancy at two different
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Histone deacetylase 10 exerts anti‐tumor effects on cervical cancer via a novel microRNA‐223/TXNIP/Wnt/β‐catenin pathway IUBMB Life (IF 3.244) Pub Date : 2021-01-22 Jinming Zhu; Shichao Han
Dysfunction of histone deacetylase 10 (HDAC10) has been suggested in the carcinogenesis of cervical cancer (CC). However, its association with microRNAs (miRNAs) in CC remains exclusive. Hence, this study aims to probe the role of HDAC10 in regulating CC cell proliferation, migration, and invasion and its correlation with the screened‐out miRNA target. Microarray analysis and RT‐qPCR revealed that
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Histone deacetylase 10 exerts anti‐tumor effects on cervical cancer via a novel microRNA‐223/TXNIP/Wnt/β‐catenin pathway IUBMB Life (IF 3.244) Pub Date : 2021-01-22 Jinming Zhu; Shichao Han
Dysfunction of histone deacetylase 10 (HDAC10) has been suggested in the carcinogenesis of cervical cancer (CC). However, its association with microRNAs (miRNAs) in CC remains exclusive. Hence, this study aims to probe the role of HDAC10 in regulating CC cell proliferation, migration, and invasion and its correlation with the screened‐out miRNA target. Microarray analysis and RT‐qPCR revealed that
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The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: possibilities for therapeutic interventions either as single agents or in combination with conventional therapies IUBMB Life (IF 3.244) Pub Date : 2021-01-21 Nader Akbari Dilmaghani; Ava Safaroghli‐Azar; Atieh Pourbagheri‐Sigaroodi; Davood Bashash
The latest advances in the sequencing methods in head and neck squamous cell carcinoma (HNSCC) tissues have revolutionized our understanding of the disease by taking off the veil from the most frequent genetic alterations in the components of the oncogenic pathways. Among all the identified alterations, aberrancies in the genes attributed to the phosphoinositide 3‐kinases (PI3K) axis have attracted
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Chitinase 3‐like‐1, Tolloid‐like protein 1, and intergenic gene polymorphisms are predictors for hepatocellular carcinoma development after hepatitis C virus eradication by direct‐acting antivirals IUBMB Life (IF 3.244) Pub Date : 2020-12-21 Nadia O. M. Mangoud; Sahar A. Ali; Mohamed El Kassas; Sameh H. Soror
Hepatocellular carcinoma (HCC) is a major cause of cancer death in Egypt. There is still a risk for HCC development even after eradicating hepatitis C virus (HCV) by direct‐acting antivirals (DAAs). Chitinase‐3‐like‐protein‐1 (CHI3L1), a biomarker for predicting many diseases, plays an essential role in inflammation, angiogenesis, and antiapoptosis. Tolloid‐like protein 1 (TLL1) may be involved in
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LncRNA UCA1 remits LPS‐engendered inflammatory damage through deactivation of miR‐499b‐5p/TLR4 axis IUBMB Life (IF 3.244) Pub Date : 2020-12-23 Yan‐jun Zhao; Yue‐e Chen; Hong‐jun Zhang; Xing Gu
Neonatal pneumonia is a high neonatal mortality disease. The current research was designed to elucidate the modulatory function and feasible molecular mechanism of UCA1 in LPS‐induced injury in pneumonia. Herein, LPS was applied to induce WI‐38 cell inflammatory damage. We displayed that UCA1 was elevated in LPS‐injured WI‐38 cells. In the functional aspect, intervention of UCA1 evidently aggrandized
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Cellulophaga algicola alginate lyase inhibits biofilm formation of a clinical Pseudomonas aeruginosa strain MCC 2081 IUBMB Life (IF 3.244) Pub Date : 2020-12-22 Sonal Mahajan; Thirumalai Nallan Chakravarthy Ramya
Alginate lyases are potential agents for disrupting alginate‐rich Pseudomonas biofilms in the infected lungs of cystic fibrosis patients but there is as yet no clinically approved alginate lyase that can be used as a therapeutic. We report here the endolytic alginate lyase activity of a recombinant Cellulophaga algicola alginate lyase domain (CaAly) encoded by a gene that also codes for an N‐terminal
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Reference intervals for routine biochemical markers and body mass index: A study based on healthcare center database in northeastern Iran IUBMB Life (IF 3.244) Pub Date : 2020-12-31 Hamideh Ghazizadeh; Mahdiyeh Yaghooti‐Khorasani; Atieh Kamel Khodabandeh; Elahe Hasanzadeh; Toktam Sahranavard; Seyed Hamed Banihashem‐Rad; Reza Zare‐Feyzabadi; Mansoureh Sadat Ekhteraee‐Toosi; Ensieh Akbarpour; Ameneh Timar; Maryam Mohammadi‐Bajgiran; Reza Assaran‐Darban; Ehsan Mosa Farkhany; Mohammad Reza Oladi; Gordon A. Ferns; Habibollah Esmaily; Majid Ghayour‐Mobarhan
Age‐ and sex‐specific reference intervals (RIs) for some biochemical tests may be useful for their interpretation, due to the variations in lifestyle and genetic, or ethnic factors. The aim of this study was to obtain RIs for some routine biochemical markers including a serum lipid profile, fasting blood glucose (FBG), aspartate and alanine aminotransferase (AST and ALT), uric acid, and body mass index
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Gallic acid‐gold nanoparticles enhance radiation‐induced cell death of human glioma U251 cells IUBMB Life (IF 3.244) Pub Date : 2020-12-28 Zhou Jing; Minghe Li; Hongyuan Wang; Zhuo Yang; Shaolong Zhou; Jian Ma; Enping Meng; Hengwei Zhang; Wulong Liang; Weihua Hu; Xinjun Wang; Xudong Fu
Glioblastoma multiforme (GBM) is among the most common adult brain tumors with invariably fatal character. Following the limited conventional therapies, almost all patients, however, presented with symptoms at the time of recurrence. It is dire to develop novel therapeutic strategies to improve the current treatment of GBM. Gallic acid is a well‐established antioxidant, presenting a promising new selective
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N6‐methyladenosine modification of circular RNA circ‐ARL3 facilitates Hepatitis B virus‐associated hepatocellular carcinoma via sponging miR‐1305 IUBMB Life (IF 3.244) Pub Date : 2020-12-28 Xi Rao; Lingling Lai; Xiaopeng Li; Liang Wang; Ai Li; Qian Yang
Hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC), whether circular RNA (circRNA) is involved in this process remains unknown. In this study, we performed circRNA microarray profile and found an HBV‐related circRNA, circ‐ARL3 (hsa_circ_0092493). Stable knockdown of circ‐ARL3 inhibited the proliferation and invasion of HBV+ HCC cells. High circ‐ARL3 was positively
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Long noncoding RNA small nucleolar RNA host gene 15 deteriorates liver cancer via microRNA‐18b‐5p/LIM‐only 4 axis IUBMB Life (IF 3.244) Pub Date : 2020-12-28 Wei Chen; Li Huang; Junhua Liang; Yingjian Ye; Sihao Yu; Yijing Zhang
Extensive studies have explored the involvements of long noncoding RNAs (lncRNAs) in liver cancer. Limitedly, the concrete function of lncRNA small nucleolar RNA host gene 15 (SNHG15) is still elusive. Therefore, the work was initiated to unearth SNHG15‐oriented mechanism in liver cancer. Liver cancer tissues were resected. The connection between SNHG15 expression with prognosis and clinicopathological
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Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate‐dependent autoproteolysis activity IUBMB Life (IF 3.244) Pub Date : 2020-12-28 Manuel Maestre‐Reyna; Wei‐Cheng Huang; Wen‐Jin Wu; Praveen K. Singh; Raimo Hartmann; Po‐Hsun Wang; Cheng‐Chung Lee; Takaaki Hikima; Masaki Yamamoto; Yoshitaka Bessho; Knut Drescher; Ming‐Daw Tsai; Andrew H.‐J. Wang
Vibrio cholerae is the causative agent of the diarrheal disease cholera, for which biofilm communities are considered to be environmental reservoirs. In endemic regions, and after algal blooms, which may result from phosphate enrichment following agricultural runoff, the bacterium is released from biofilms resulting in seasonal disease outbreaks. However, the molecular mechanism by which V. cholerae
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Tea bioactive components prevent carcinogenesis via anti‐pathogen, anti‐inflammation and cell survival pathways IUBMB Life (IF 3.244) Pub Date : 2020-12-27 Xiangqi Fan; Xiangjun Xiao; Xiangbing Mao; Daiwen Chen; Bing Yu; Jianping Wang; Hui Yan
Cancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improvements in human health. Tea contains many active components, including tea polyphenols
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Toll‐like receptors (TLRs) in cancer; with an extensive focus on TLR agonists and antagonists IUBMB Life (IF 3.244) Pub Date : 2020-11-20 Ali Keshavarz; Atieh Pourbagheri‐Sigaroodi; Parisa Zafari; Nader Bagheri; Seyed H. Ghaffari; Davood Bashash
At the forefront of the battle against pathogens or any endogenously released molecules, toll‐like receptors (TLRs) play an important role as the most noble pattern recognition receptors. The ability of these receptors in distinguishing “self” and “non‐self” antigens is a cornerstone in the innate immunity system; however, misregulation links inflammatory responses to the development of human cancers
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Tuberculosis comorbidity with rheumatoid arthritis: Gene signatures, associated biomarkers, and screening IUBMB Life (IF 3.244) Pub Date : 2020-11-20 Parisa Zafari; Monireh Golpour; Nasim Hafezi; Davood Bashash; Seyed‐Alireza Esmaeili; Naeimeh Tavakolinia; Alireza Rafiei
Rheumatoid arthritis (RA) is known to be related to an elevated risk of infections because of its pathobiology and the use of immunosuppressive therapies. Reactivation of latent tuberculosis (TB) infection is a serious issue in patients with RA, especially after receiving anti‐TNFs therapy. TNF blocking reinforces the TB granuloma formation and maintenance and the growth of Mycobacterium tuberculosis
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Structure, catalysis, and inhibition mechanism of prenyltransferase IUBMB Life (IF 3.244) Pub Date : 2020-11-27 Hsin‐Yang Chang; Tien‐Hsing Cheng; Andrew H.‐J. Wang
Isoprenoids, also known as terpenes or terpenoids, represent a large family of natural products composed of five‐carbon isopentenyl diphosphate or its isomer dimethylallyl diphosphate as the building blocks. Isoprenoids are structurally and functionally diverse and include dolichols, steroid hormones, carotenoids, retinoids, aromatic metabolites, the isoprenoid side‐chain of ubiquinone, and isoprenoid
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An overview of the innate and adaptive immune system in atherosclerosis IUBMB Life (IF 3.244) Pub Date : 2020-12-07 Mina Mohmmad‐Rezaei; Reza Arefnezhad; Reza Ahmadi; Meghdad Abdollahpour‐Alitappeh; Yousef Mirzaei; Mohammad‐Hassan Arjmand; Gordon A. Ferns; Davood Bashash; Nader Bagheri
Cardiovascular disease is the leading cause of death globally. Coronary artery disease (CAD) is a chronic inflammatory disease usually caused by atherosclerosis, in which the coronary arteries become narrowed by atheromatous plaque. Plaques in atherosclerosis are formed through the accumulation of lipids and various immune cells. Both adaptive and innate immune systems are involved in the pathogenesis
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Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression IUBMB Life (IF 3.244) Pub Date : 2020-11-07 Yaying Yu; Yanwei Xing; Qian Zhang; Qianqian Zhang; Shuangjian Huang; Xinxin Li; Chao Gao
The foods of plants provide the rich nutrition and have protective function in human diseases, including cancers. Genistein is a major isoflavone constituent in soybeans, which has an anti‐cancer role in non‐small‐cell lung cancer (NSCLC). Nevertheless, the mechanism underlying the anti‐cancer function of genistein in NSCLC remains largely unknown. NSCLC cells (H292 and A549) were exposed to genistein
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m6A methyltransferase Wilms' tumor 1‐associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual‐specificity phosphatases 6 expression via m6A RNA methylation IUBMB Life (IF 3.244) Pub Date : 2020-11-17 HongYan Ma; LiYun Shen; Hua Yang; HongTao Gong; XingJun Du; JunBo Li
Nasal‐type natural killer/T‐cell lymphoma (NKTCL) is an aggressive malignancy with poor survival outcomes that is relatively resistant to chemotherapy. N6‐Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA, is involved in the progression of various tumors. However, it is unclear whether it has a physiological role in NKTCL development. To address this question
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Elevated microRNA‐130b‐5p or silenced ELK1 inhibits self‐renewal ability, proliferation, migration, and invasion abilities, and promotes apoptosis of cervical cancer stem cells IUBMB Life (IF 3.244) Pub Date : 2020-12-08 Yu Huang; Fangyuan Luo
Cervical cancer (CC) is the most familiar gynecological malignancy. With the poor prognosis of CC patients, this study explored the effect of microRNA (miR)‐130b‐5p targeting ELK1 expression on self‐renewal ability and stemness of CC stem cells. The tissues of patients with CC or cervical benign lesions were collected. MiR‐130b‐5p and ELK1 expression was detected by reverse transcription quantitative
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Effects of different autophagy inhibitors on sensitizing KG‐1 and HL‐60 leukemia cells to chemotherapy IUBMB Life (IF 3.244) Pub Date : 2020-11-17 Atousa Haghi; Mahdieh Salemi; Aila Fakhimahmadi; Mahnaz Mohammadi Kian; Hassan Yousefi; Marveh Rahmati; Saeed Mohammadi; Ardeshir Ghavamzadeh; Mohammad Amin Moosavi; Mohsen Nikbakht
A little number of current autophagy inhibitors may have beneficial effects on the acute myeloid leukemia (AML) patients. However, there is a strong need to figure out which settings should be activated or inhibited in autophagy pathway to prevail drug resistance and also to improve current treatment options in leukemia. Therefore, this study aimed to compare the effects of well‐known inhibitors of
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ATF4‐modified serum exosomes derived from osteoarthritic mice inhibit osteoarthritis by inducing autophagy IUBMB Life (IF 3.244) Pub Date : 2020-11-28 Yan Wang; Shi‐Hao He; Xu Liang; Xin‐Xin Zhang; Shan‐Shan Li; Tian‐Fang Li
Activating transcription factor 4 (ATF4) is critical for chondrocyte proliferation and bone formation. Exosomes are considered as promising gene‐delivery vehicles for the treatment of osteoarthritis (OA). This study utilized the serum‐derived exosomes from OA mice as the gene‐delivery vehicles for ATF4 gene therapy and explored their therapeutic effects on OA. Meniscus injury‐induced OA model was established
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Circ_0109046 promotes the malignancy of endometrial carcinoma cells through the microRNA‐105/SOX9/Wnt/β‐catenin axis IUBMB Life (IF 3.244) Pub Date : 2020-11-21 Yanyan Li; Jinyu Liu; Jinxia Piao; Jian Ou; Xiaoyan Zhu
Emerging evidence suggests the important involvements of circular RNAs (circRNAs) in cancer progression. This study focuses on the function of Circ_0109046 on the malignancy of endometrial carcinoma (EC) cells and the molecules involved. First, high expression of Circ_0109046 was found in EC tissues compared to the adjacent tissues, and it predicted unfavorable prognosis in patients. Similarly, high
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Oxidized low‐density lipoprotein accelerates the injury of endothelial cells via circ‐USP36/miR‐98‐5p/VCAM1 axis IUBMB Life (IF 3.244) Pub Date : 2020-11-28 Kuang Peng; Peiyong Jiang; Yafang Du; Dianmei Zeng; Junbi Zhao; Meiling Li; Chunchen Xia; Zhong Xie; Jie Wu
Circular RNAs (circRNAs) are a group of RNAs featured by a covalently closed continuous loop structure. This study aimed to uncover the function and mechanism of circ‐ubiquitin specific peptidase 36 (USP36) in endothelial cells treated with oxidized low‐density lipoprotein (ox‐LDL). The levels of circ‐USP36, microRNA‐98‐5p (miR‐98‐5p) and vascular cell adhesion molecule 1 (VCAM1) were examined by a
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LINC00261/microRNA‐550a‐3p/SDPR axis affects the biological characteristics of breast cancer stem cells IUBMB Life (IF 3.244) Pub Date : 2020-12-03 Yi Li; Chihua Wu
Long non‐coding RNAs (lncRNAs) have been shown to play key roles in the pathogenesis of breast cancer (BC). The study was to explore the effect of long non‐coding RNA LINC00261/microRNA (miR)‐550a‐3p/serum deprivation response (SDPR) axis on the biological characteristics of BC stem cells (BCSCs). BC and adjacent normal tissues of patients were collected. LINC00261, miR‐550a‐3p and SDPR expression
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Long non‐coding RNA HULC protects against atherosclerosis via inhibition of PI3K/AKT signaling pathway IUBMB Life (IF 3.244) Pub Date : 2020-12-07 Dan Mu; Danyan Li; Jianhui Li; Hongming Yu; Wenping Chen; Jing Liang; Dongmei Wang; Aimei Li; Zhao Qing; Bing Zhang
Studies on the roles of long non‐coding RNA in atherosclerosis (AS) have been extensively explored. However, the action of lncRNA highly upregulated in liver cancer (HULC) in AS still needs in‐depth investigations. Hence, this study is launched towards the translation of HULC‐oriented mechanism in AS. Mouse AS models were established by high cholesterol and high fat feeding. AS mice were injected with
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Parathyroid hormone ameliorates osteogenesis of human bone marrow mesenchymal stem cells against glucolipotoxicity through p38 MAPK signaling IUBMB Life (IF 3.244) Pub Date : 2020-11-28 Yuli Wang; Lintong Huang; Ziyue Qin; Hua Yuan; Bing Li; Yongchu Pan; Xiaoqian Wang; Xin Du; Shushu Hao; Yifei Du; Ruixia Wang; Yi Shen
Diabetes mellitus (DM)‐induced glucolipotoxicity is a factor strongly contributing to alveolar bone deficiency. Parathyroid hormone (PTH) has been identified as a main systemic mediator to balance physiological calcium in bone. This study aimed to uncover PTH's potential role in ameliorating the osteogenic capacity of human bone marrow mesenchymal stem cells (HBMSCs) against glucolipotoxicity. Optimal
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Expression levels of miR‐27a, miR‐329, ABCA1, and ABCG1 genes in peripheral blood mononuclear cells and their correlation with serum levels of oxidative stress and hs‐CRP in the patients with coronary artery disease IUBMB Life (IF 3.244) Pub Date : 2020-12-01 Ali Rafiei; Gordon A. Ferns; Reza Ahmadi; Arsalan Khaledifar; Tina Rahimzadeh‐Fallah; Mina Mohmmad‐Rezaei; Shohreh Emami; Nader Bagheri
Atherosclerosis is a chronic inflammatory disease with high mortality worldwide. The reverse cholesterol transport pathway in macrophage plays an important role in the pathogenesis of coronary artery disease (CAD) and is strongly controlled by regulatory factors. The microRNAs can promote or prevent the formation of atherosclerotic lesions by post‐transcriptional regulation of vital genes in this pathway
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Enhancer of zeste homolog 2 participates in the process of atherosclerosis by modulating microRNA‐139‐5p methylation and signal transducer and activator of transcription 1 expression IUBMB Life (IF 3.244) Pub Date : 2020-12-17 Xuwei Zheng; Xiaoyan Zhao; Zhanying Han; Kui Chen
Atherosclerosis (AS) is the main cause of coronary heart disease, in which enhancer of zeste homolog 2 (EZH2) has been implied to participate in this process. Thus, this work proposed to explore the effect of EZH2 on AS from microRNA‐139‐5p (miR‐139‐5p)/signal transducer and activator of transcription 1 (STAT1) axis. EZH2, miR‐139‐5p, and STAT1 expression in arterial tissues of AS patients were detected
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Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high‐fat diet fed mice IUBMB Life (IF 3.244) Pub Date : 2020-12-16 Fahimeh Zamani‐Garmsiri; Ghasem Ghasempour; Masoume Aliabadi; Seyyed Mohammad Reza Hashemnia; Solaleh Emamgholipour; Reza Meshkani
Non‐alcoholic fatty liver disease (NAFLD) has become an important health problem in the world. Natural products, with anti‐inflammatory properties, are potential candidates for alleviating NAFLD. Metformin (MET) and chlorogenic acid (CGA) have been reported to be effective in the improvement of NAFLD. Here, we aimed to evaluate the efficacy of MET and CGA combination in ameliorating NAFLD in high‐fat
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MiR‐770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway IUBMB Life (IF 3.244) Pub Date : 2020-12-16 Bin Jia; Sanke Zhang; Shuang Wu; Qiuyu Zhu; Wenlu Li
Oral squamous cell carcinoma (OSCC) is a common malignant cancer with unfavorable prognosis, and the epithelial‐to‐mesenchymal transition (EMT) is a critical contributor to OSCC metastasis. Recently, we have shown that sirtuin 7 (Sirt7) is associated with EMT and OSCC metastasis by acetylating small mother against decapentaplegic 4 (Smad4). Nonetheless, the mechanism of Sirt7 downregulation in OSCC
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Knockdown of lncRNA TTTY15 alleviates myocardial ischemia–reperfusion injury through the miR‐374a‐5p/FOXO1 axis IUBMB Life (IF 3.244) Pub Date : 2020-12-09 Yong‐Quan Chen; Xin Yang; Wei Xu; Yi Yan; Xi‐Ming Chen; Zhao‐Qi Huang
Myocardial ischemia/reperfusion (I/R) injury greatly contributes to myocardial tissue damage in patients with coronary disease, which eventually leads to heart failure. Long noncoding RNAs (lncRNAs) have an emerging role in the process of myocardial I/R injury. Our previous work revealed the protective role of miR‐374a‐5p against myocardial I/R injury. In this study, we explored the role of lncRNA
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LncRNA RAD51‐AS1/miR‐29b/c‐3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer IUBMB Life (IF 3.244) Pub Date : 2020-12-12 Caiping Li; Pengcheng Wang; Jiabin Du; Junxing Chen; Weinan Liu; Kai Ye
LncRNAs are recently increasingly emerging as molecules that take its part in human carcinogenesis. A large body of literature has identified the functional roles of lncRNAs in the pathophysiology of CRC. The current study was intended to provide new ideas and perspectives for the functional role of lncRNA RAD51‐AS1 in regulating CRC progression. Herein, a survey of RAD51‐AS1 expression profile in
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Not all mitochondrial DNAs are made equal and the nucleus knows it IUBMB Life (IF 3.244) Pub Date : 2020-12-25 Ana Victoria Lechuga‐Vieco; Raquel Justo‐Méndez; José Antonio Enríquez
The oxidative phosphorylation (OXPHOS) system is the only structure in animal cells with components encoded by two genomes, maternally transmitted mitochondrial DNA (mtDNA), and biparentally transmitted nuclear DNA (nDNA). MtDNA‐encoded genes have to physically assemble with their counterparts encoded in the nucleus to build together the functional respiratory complexes. Therefore, structural and functional
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Long non‐coding RNAs as potential biomarkers in the prognosis and diagnosis of lung cancer: A review and target analysis IUBMB Life (IF 3.244) Pub Date : 2020-12-24 Younes Aftabi; Khalil Ansarin; Dariush Shanehbandi; Majid Khalili; Ensiyeh Seyedrezazadeh; Leila Rahbarnia; Milad Asadi; Amir Amiri‐Sadeghan; Venus Zafari; Shirin Eyvazi; Nasim Bakhtiyari; Habib Zarredar
Long non‐coding RNAs (lncRNA) have been emerged as a novel class of molecular regulators in cancer. They are dysregulated in many types of cancer; however, there is not enough knowledge available on their expression and functional profiles. Lung cancer is the leading cause of the cancer deaths worldwide. Generally, lncRNAs may be associated with lung tumor pathogenesis and they may act as biomarkers
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Remimazolan inhibits glioma cell growth and induces apoptosis through down‐regulation of NF‐κB pathway IUBMB Life (IF 3.244) Pub Date : 2020-12-24 Wei Xu; Jiamei Hu; Weiwei Liu; Qiong Zhu; Xuan Gong; Pengpeng Zhu; Xiao Yang; Rui Xia; Rui Xue
Glioma alone accounts for 30% of various kinds of primary brain tumors and is the highest cause of mortality associated with intracranial malignant cancers. In the present study, Suzuki‐coupling products of remimazolan were synthesized and investigated for anti‐neoplastic property against glioma cells. RFMSP treatment for 48 hr suppressed viabilities of U‐118MG and U87MG cells in dose dependent manner
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Ursolic acid ameliorates hypobaric hypoxia‐induced skeletal muscle protein loss via upregulating Akt pathway: An experimental study using rat model IUBMB Life (IF 3.244) Pub Date : 2020-12-24 Richa Rathor; Akanksha Agrawal; Ravi Kumar; Geetha Suryakumar; Som Nath Singh
Hypobaric hypoxic stress leads to oxidative stress, inflammation, and disturbance in protein turnover rate. Aggregately, this imbalance in redox homeostasis is responsible for skeletal muscle protein loss and a decline in physical performance. Hence, an urgent medical need is required to ameliorate skeletal muscle protein loss. The present study investigated the efficacy of ursolic acid (UA), a pentacyclic
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Iron accumulation regulates osteoblast apoptosis through lncRNA XIST/miR‐758‐3p/caspase 3 axis leading to osteoporosis IUBMB Life (IF 3.244) Pub Date : 2020-12-18 Hu Liu; Yu‐Wu Wang; Wei‐Dong Chen; Hong‐Hua Dong; You‐Jia Xu
Postmenopausal osteoporosis (PMOP) is mainly caused by multiple factors. Recent studies have suggested that iron accumulation was closely related to PMOP. However, the detailed molecular mechanisms have not been well demonstrated.
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Novel therapeutic regimens for urethane‐induced early lung cancer in rats: Combined cisplatin nanoparticles with vitamin‐D3 IUBMB Life (IF 3.244) Pub Date : 2020-12-17 Eman Radwan; Maha Ali; Soad M. A. Faied; Hossam M. Omar; Wael S. Mohamed; Sary Kh. Abd‐Elghaffar; Ayat A. Sayed
Lung cancer remains incurable; therefore, novel therapeutical approaches are of great demand. This study was designed to investigate the effectiveness of cisplatin nanoparticles combined with vitamin‐D3 on urethane‐induced early lung cancer in rats and to clarify the underlying signaling mechanisms. Early lung cancer was induced in male Wistar rats by urethane. Rats were divided into six groups: I‐control
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Angiotensin‐converting enzyme 2: A protective factor in regulating disease virulence of SARS‐COV‐2 IUBMB Life (IF 3.244) Pub Date : 2020-10-08 Vignesh Mariappan; Rao S. R.; Agieshkumar Balakrishna Pillai
Novel SARS‐CoV‐2 named due to its close homology with severe acute respiratory syndrome coronavirus (SARS‐CoV) is the etiologic agent for the ongoing pandemic outbreak causing loss of life and severe economic burden globally. The virus is believed to be evolved in a recombined form of bat and animal coronavirus with the capacity to infect human host using the ACE2 receptors as an entry point. Though
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Circulating exosomal microRNAs as emerging non‐invasive clinical biomarkers in heart failure: Mega bio‐roles of a nano bio‐particle IUBMB Life (IF 3.244) Pub Date : 2020-10-14 Runfa Zhou; Leiyan Wang; Gang Zhao; Dan Chen; Xiaoning Song; Amir A. Momtazi‐Borojeni; Haitao Yuan
Exosomes are nano‐sized extracellular vesicles containing a cell‐specific biologically active cargo of proteins and genetic materials. Exosomes are constitutively released from almost all cell‐types and affect neighboring or distant cells through a complex intercellular exchange of the genetic information and/or regulation of certain gene expressions that change the function and behavior of recipient
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Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta‐analysis IUBMB Life (IF 3.244) Pub Date : 2020-10-22 Alireza Hejrati; Mahdi Taghadosi; Reza Alizadeh‐Navaei; Shahnaz Hosseinzadeh; Davood Bashash; Mozhgan Esmaili; Parisa Zafari
Rheumatoid arthritis (RA) is a chronic autoimmune disease caused by established chronic inflammation. Neopterin levels have extensively been considered as a marker of immune activation during inflammation. In this study, we performed a systematic evaluation and meta‐analysis to elucidate the overall relationship between neopterin concentration and RA disease activity. Following the Preferred Reporting
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The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine IUBMB Life (IF 3.244) Pub Date : 2020-10-27 Zahra Ghaneifar; Zahra Yousefi; Fatemeh Tajik; Banafsheh Nikfar; Fatemeh Ghalibafan; Elham Abdollahi; Amir Abbas Momtazi‐Borojeni
Pregnancy complications including preeclampsia, preterm birth, intrauterine growth restriction, and gestational diabetes are the main adverse reproductive outcomes. Excessive inflammation and oxidative stress play crucial roles in the pathogenesis of pregnancy disorders. Curcumin, the main polyphenolic compound derived from Curcuma longa, is mainly known by its anti‐inflammatory and antioxidant properties
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Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes IUBMB Life (IF 3.244) Pub Date : 2020-11-09 Alexander C. Jones; Susan S. Taylor; Alexandra C. Newton; Alexandr P. Kornev
Protein kinase C (PKC) family members are multi‐domain proteins whose function is exquisitely tuned by interdomain interactions that control the spatiotemporal dynamics of their signaling. Despite extensive mechanistic studies on this family of enzymes, no structure of a full‐length enzyme that includes all domains has been solved. Here, we take into account the biochemical mechanisms that control
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Exosomes derived from T regulatory cells relieve inflammatory bowel disease by transferring miR‐195a‐3p IUBMB Life (IF 3.244) Pub Date : 2020-10-26 Fei Liao; Xiaohong Lu; Weiguo Dong
Previous studies have demonstrated the therapeutic effects of regulatory T (Treg) cells on inflammatory bowel disease (IBD), but the mechanism is not well‐understood. Exosomes have been proposed as a novel mechanism underlying the action of Tregs. This study aimed to investigate the therapeutic effects of exosomes secreted by Treg cells (Treg‐Exo) on IBD and to explore the underlying mechanism. Treg‐Exo
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Effects of the MTOR and AKT1 genes polymorphisms on papillary thyroid cancer development IUBMB Life (IF 3.244) Pub Date : 2020-10-26 Rostam Maruei‐Milan; Mohsen Saravani; Zahra Heidari; Mina Asadi‐Tarani; Saeedeh Salimi
Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising 80% of all thyroid malignancies. The phosphoinositide‐3‐kinase–protein kinase B/Akt (PI3K‐PKB/Akt) pathway is a main pathway in control of cell growth. Activated mTOR and Akt are involved in the development and progression of the PTC. This study aimed to evaluate the effects of MTOR (rs2536 and rs2295080) and AKT1
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A long‐acting isomer of Ac‐SDKP attenuates pulmonary fibrosis through SRPK1‐mediated PI3K/AKT and Smad2 pathway inhibition IUBMB Life (IF 3.244) Pub Date : 2020-11-02 Yueyuan Qiu; Zhaowei Wang; Xutao Zhang; Ping Huang; Wangqian Zhang; Kuo Zhang; Shuning Wang; Lei He; Yanhai Guo; An Xiang; Cun Zhang; Qiang Hao; Meng Li; Weina Li; Yingqi Zhang
Idiopathic pulmonary fibrosis (IPF) is a progressive, life‐threatening lung disease with a poor prognosis. N‐acetyl‐seryl‐aspartyl‐lysyl‐proline (Ac‐SDKP) is a critical negative regulator of fibrosis development. However, it's extremely short half‐life greatly limits its applications. Previously, we reported an Ac‐SDKP analog peptide in which Asp and Lys residues were replaced with D‐amino acids (Ac‐SDDKDP)
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Silencing of long non‐coding RNA DLX6‐AS1 weakens neuroblastoma progression by the miR‐513c‐5p/PLK4 axis IUBMB Life (IF 3.244) Pub Date : 2020-10-08 Peisheng Jia; Erhu Wei; Huiqiong Liu; Tingting Wu; Huaili Wang
Emerging evidence has demonstrated the crucial roles of long noncoding RNAs in human cancers, including neuroblastoma (NB). DLX6 antisense RNA 1 (DLX6‐AS1) has been identified as an oncogenic driver in NB. However, the mechanisms of DLX6‐AS1 in NB progression are not fully understood. Our data showed that DLX6‐AS1 was significantly overexpressed in NB tissues and cells. Moreover, DLX6‐AS1 silencing
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Nanotized curcumin‐benzothiophene conjugate: A potential combination for treatment of cerebral malaria IUBMB Life (IF 3.244) Pub Date : 2020-10-09 Aparajita Ghosh; Tanushree Banerjee
The declining effectiveness of the available antimalarial drugs due to drug resistance requires a continued effort to develop new therapeutic approaches. In this context, combination therapies hold a great promise for developing effective first‐line antimalarial treatments for reducing malaria mortality. The present study explores the antimalarial efficacy of nanotized formulation of curcumin in combination
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M2 macrophage‐derived exosomal miR‐25‐3p improves high glucose‐induced podocytes injury through activation autophagy via inhibiting DUSP1 expression IUBMB Life (IF 3.244) Pub Date : 2020-10-26 Haihua Huang; Huiyun Liu; Jiazhen Tang; Wenqiong Xu; Huaxia Gan; Qiwei Fan; Wei Zhang
Diabetic nephropathy (DN) is the primary reason of chronic kidney disease. The aim of our study is to explore the role and action mechanism of M2 macrophage‐derived exosomes in high glucose (HG)‐induced podocytes injury. Here, 30 mmol/L of HG was used to induce podocytes injury. Annexin V‐FITC/PI double staining was performed to measure podocytes apoptosis, and western blot was carried out to ensure
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Silencing of lncRNA Gm14461 alleviates pain in trigeminal neuralgia through inhibiting astrocyte activation IUBMB Life (IF 3.244) Pub Date : 2020-11-03 Jun Cai; Yi Yan; Daying Zhang; Mengye Zhu; Zhijian Wang; Xuexue Zhang; Mu Xu
Our previous study showed that silencing of lncRNA Gm14461 alleviated pain in a murine model of trigeminal neuralgia (TN), but the molecular mechanism remains not fully understood. Evidence indicates that astrocyte activation and autophagy are involved in the development of TN. Herein, this study aimed to elucidate whether the pain‐relief effect of Gm14461 silencing in TN involved regulation of astrocyte
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LMNB2 is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma IUBMB Life (IF 3.244) Pub Date : 2020-11-19 Weihao Kong; Zihao Wu; Mingwei Yang; Xiaomin Zuo; Guanfu Yin; Wei Chen
Previous studies have suggested Lamin B2 (LMNB2) as an oncogene in lung cancer. However, the role of LMNB2 in hepatocellular carcinoma (HCC) remains unclear.
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Atg16l1 in dendritic cells is required for antibacterial defense and autophagy in murine colitis IUBMB Life (IF 3.244) Pub Date : 2020-11-07 Hong Zhang; Dong Wang; David Q. Shihb; Xiao‐Lan Zhang
Autophagy‐related 16‐like 1 (Atg16l1) contributes to the susceptibility to ulcerative colitis (UC). The functional consequences of Atg16l1 in UC pathogenesis are poorly understood. We aimed to confirm how Atg16l1 deficiency in dendritic cells (DCs) affects murine colitis development. Atg16l1f/f mice and mice with Atg16l1 deficiency in CD11c+DCs (Atg16l1ΔDC) were generated for colitis models induction
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Inhibited histone deacetylase 3 ameliorates myocardial ischemia–reperfusion injury in a rat model by elevating microRNA‐19a‐3p and reducing cyclin‐dependent kinase 2 IUBMB Life (IF 3.244) Pub Date : 2020-11-20 Kaiyou Song; Lianting Li; Qingqing Quan; Yanjin Wei; Shunpeng Hu
Over the years, the roles of microRNAs (miRNAs) and histone deacetylase 3 (HDAC3) in human diseases have been investigated. This study focused on the effect of miR‐19a‐3p and HDAC3 in myocardial ischemia–reperfusion (I/R) injury (MIRI) by targeting cyclin‐dependent kinase 2 (CDK2).
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Angiopoietin‐like protein 4 promotes very‐low‐density lipoprotein assembly and secretion in bovine hepatocytes in vitro IUBMB Life (IF 3.244) Pub Date : 2020-11-17 Yezi Kong; Chenxu Zhao; Yan Huang; Yaoquan Liu; Siqi Liu; Yazhou Guo; Manxia Li; Tingxuan Xu; Baoyu Zhao; Jianguo Wang
In dairy cows, fatty liver is one of the most common metabolic diseases that occurs during the periparturient period. Angiopoietin‐like protein 4 (ANGPTL4) is a well‐known downstream target of peroxisome proliferator‐activated receptors (PPARs), which regulate the glucose and fatty acid metabolisms. The inhibition of lipoprotein lipase (LPL) activity interferes with the storage of triglycerides (TG)
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Mitochondria and nucleus cross‐talk: Signaling in metabolism, apoptosis, and differentiation, and function in cancer IUBMB Life (IF 3.244) Pub Date : 2020-11-12 Anna Shteinfer‐Kuzmine; Ankit Verma; Tasleem Arif; Or Aizenberg; Avijit Paul; Varda Shoshan‐Barmaz
The cross‐talk between the mitochondrion and the nucleus regulates cellular functions, including differentiation and adaptation to stress. Mitochondria supply metabolites for epigenetic modifications and other nuclear‐associated activities and certain mitochondrial proteins were found in the nucleus. The voltage‐dependent anion channel 1 (VDAC1), localized at the outer mitochondrial membrane (OMM)
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Cytochrome c oxidase‐modulatory near‐infrared light penetration into the human brain: Implications for the noninvasive treatment of ischemia/reperfusion injury IUBMB Life (IF 3.244) Pub Date : 2020-11-09 Paul T. Morse; Dennis J. Goebel; Junmei Wan; Samuel Tuck; Lara Hakim; Charlotte L. Hüttemann; Moh H. Malek; Icksoo Lee; Thomas H. Sanderson; Maik Hüttemann
Near‐infrared light (IRL) has been evaluated as a therapeutic for a variety of pathological conditions, including ischemia/reperfusion injury of the brain, which can be caused by an ischemic stroke or cardiac arrest. Strategies have focused on modulating the activity of mitochondrial electron transport chain (ETC) enzyme cytochrome c oxidase (COX), which has copper centers that broadly absorb IRL between
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Issue Highlights IUBMB Life (IF 3.244) Pub Date : 2020-10-28
2290 Regulation of ferroptosis by ncRNA: A new direction Yujia Li, Min Shen, Chun Jin, Liyuan Gao, Baoyu Liang, Zhenyi Wang, Shanzhong Tan, Anping Chen, Feng Zhang, Zili Zhang and Shizhong Zheng Ferroptosis is a genetically encoded program of cell death that results from iron‐dependent lipid peroxidation. Non‐coding RNA (ncRNA) is a kind of small RNA molecules found in recent years, which can transcribe
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The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway. IUBMB Life (IF 3.244) Pub Date : 2020-09-11 Piet Borst
This article presents a personal and critical review of the history of the malate–aspartate shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a route for the oxidation of cytosolic NADH by the mitochondria in Ehrlich ascites cell tumor lacking other routes, and to explain the need for a mitochondrial aspartate aminotransferase (glutamate oxaloacetate transaminase
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