In this study, the novel compound (4-amino-2-(4-methoxyphenyl)aminothiazol-5yl)(thiophene-2-yl)methanone was synthesized and structure of the compound was elucidated by FTIR, 1H NMR, 13C NMR, and High resolution mass spectrometric techniques. The compound was optimized with B3LYP-6-311+G (d, p) density functional theory method. Stability and intermolecular charge transfer have been analyzed by natural

Laser irradiation therapy on cancer cells is a promising alternative in providing a non-invasive treatment of breast cancer that has a possibility to inhibit cancerous cells selectively without damaging surrounding healthy tissues. This present study aimed to evaluate the effect of the low-level green laser of 532 nm wavelength with various laser power and irradiation time on MCF-7 cancer cell lines

During progressive chronic kidney disease, toxic substances known as uremic toxins accumulate in body fluids. Uremia toxin has been documented to be involved in most inflammatory reactions, and indoxyl-sulfate (IS) a major serum metabolite of uremia is a key player in this. The mechanism by which uremia toxin establishes it inflammatory activity is scarcely known; however, researchers believes that

The 3-(2-alkylaminothiazol-5-oyl)pyridines were synthesized and characterized by different physicochemical techniques such as IR, 1H NMR, MS, electronic parameters etc. Geometrical and electronic properties of 3-(2-alkylaminothiazol-5-oyl)pyridines derivatives was computed theoretically using B3LYP /6-31G (d, p) basis sets. The energy gap between HOMO and LUMO explained the charge transfer within the

We try to identify the impact of innovation headways and its rapid affect in each field of life, be it clinical or some other field; computerized reasoning deployed the prominent approach for indicating the authenticated outcomes in the field of medical services through its dynamic nature in investigating the information. COVID-19 has influenced all the nations around the globe in a short period of

Rocky mountain spotted fever is a severe disease caused by Rickettsia rickettsii that frequently causes the death of the patients. As there are not effective vaccines for this disease, we employed reverse vaccinology to find epitope candidates useful for vaccine development. To apply this bioinformatics, we used the following online software: ProPred1, RANKPEP, and HLA binding, to evaluate 143 amino

Phenol is a notorious persistent bioaccumulative toxic substance. Being a primary pollutant, phenol has to be removed completely due to its toxicity even at low concentrations. Now-a-days the use of low cost adsorbents for the effective removal of contaminants from waste water poses a big challenge to the researchers. Modified laterite, a cheap and effective adsorbent was chosen as the adsorbent in

The vegetable production comes with a considerable amount of putrescible biowastes. Nowadays, biowaste production and its underutilizationis perceived as the primary concerns, due to the economic and environmental expenses associated with its disposal. Eggplant peel is discarded sometimes as a biowaste that leads to the substantial losses of organic substances which often have very high levels of crucial

Exopolysaccharides (EPS) produced by several bacteria including the probiotic lactic acid bacteria (LAB) not only help them to execute certain vital life functions, but offers huge potential for applications in sectors like medical/pharmaceutical, food, agriculture, and environmental health. However, low yield of EPS from probiotic LAB has always been a challenge. Previously we have reported that EPS

Psoriasis is a chronic immune-mediated inflammatory skin disease, in which pruritus is a common feature and also affects the social well-being of individuals with psoriasis significantly. The transient receptor potential cation channel, subfamily V, member 3 (TRPV3) is believed to be involved in hypersensation and generation of itching in the case of psoriasis. The purpose of the present study was

This study has been performed to isolate a potential strain able to release the prolific amylase under non-aqueous conditions to meet the current demand in industries to substitute the amylase produced in aqueous media. A bacterial strain that produces organic solvent-stable amylase in the media containing 15% benzene was isolated from the soil. The recovered strain was identified to be Bacillus amyloliquefaciens

The major thrust of our study confers to the identification of non-synonymous and intronic variants of the DENND1A gene via in silico methods and determination of its effect on the structural integrity of the protein. The outcome identifies potential disease -causing SNPs. The pathogenic variants of DENND1A were deduced via in silico analysis using various tools that include SIFT, PolyPhen-2, PROVEAN

The attack of COVID-19 has been a threat to the public health rendering it a global war by the humans against a deadly virus and the soldiers of this battle are the frontline healthcare workers. They are most vulnerable to infection and other adverse effects which have profound emotional impact on them. These factors can result in different types of psychological pressure that trigger feelings of loneliness

This study examines whether the glucose regulating enzymes mediate hypoglycaemic effect of diallyl disulphide (DADS) since the biochemical mechanisms by which the latter regulates hepatic glucose-metabolizing enzymes remain unknown. Hepatic hexokinase, glucose-6-P-D and pyruvate kinase are the important glucose metabolising enzymes that control blood glucose homeostasis and considered to be potential

Photodynamic therapy works with a photosensitizer that is stimulated when exposed to a light source of a specific wavelength and produces a form of oxygen that can be used in cancer treatments. In this study, we investigated the effect of laser on apoptosis on breast cancer cell lines (MDA-MB-231) treated with verteporfin in cell culture media. Verteporfin added MDA-MB-231 cells were incubated without

Hypertension is the major risk factor for cardiovascular diseases and stroke and it is one of leading causes of disability and mortality worldwide. The present study was aimed to investigate the antihypertensive and vasodilation properties of chrysin, a naturally occurring flavone, in hypertensive rats. Hypertension was induced using Nω-nitro-l arginine methyl ester (L-NAME; 40 mg/kg BWT/day for 4

Simmondsin is a type of flavonoid it belongs to the group of flavan-3-ols (or simply flavanols (phenols). Phenolic compounds are known as antioxidants. In this study, we explain simmondsin’s antioxidant mechanism and investigate it to determine if it can be used as an anticancer therapeutic agent or not. Our results show that simmondsin is a very strong antioxidant that prefers hydrogen atom transfer

The study explores the inhibition effects of MicroRNAs in osteosarcoma, as a means of suggesting it as treatment for bone cancer. MicroRNAs (miRNAs) are a sort of noncoding RNA molecules that regulates gene expression by targeting mRNAs and play critical roles in tumor development. This study probed the effect of miR-9-5p on osteosarcoma development. Human osteosarcoma cell lines U2-OS, 143B, MG63

Interactions of current pandemic COVID-19 and pre-existing major health burden Diabetes Mellitus have posed a serious global public health crisis. The emergence of COVID-19 as a communicable viral infection along with the presence of non-communicable diabetes, have transformed the health system into a knife with two sharp ends. Though diabetes worldwide is almost 20 times more than COVID-19 positive

The contemporary scientific community has presently recognized flavonoids to be a unique class of therapeutic molecules due to their diverse therapeutic properties. Of these, catechin, also, has been explored for a number of pharmacological effects. The present review aims to document the therapeutic potential of catechin. Tea leave, catechu, and much more possess catechin as one of the active constituents

This work aimed to investigate the effect of acute and chronic administration of gold nanoparticles (GNPs) on liver and kidney functions, blood glucose concentration, lipid profile, and haematological parameters in male albino rats. Two experiments were conducted. In acute study: Fifty-four adult mature male rats were randomly assigned into three equal groups (18 per group). Group 1 (control group):

A total of 61 bacterial strains was isolated in soils from Chittoor and Kadapa districts of Andhra Pradesh, India using sodium acetate selection method and preliminarily identified as Bacillus thuringiensis based on Gram's staining, endospore staining and crystal protein study. These strains were tested against the insect, Spodoptera litura under laboratory conditions and found 18 strains with ≥ 50%

Auramine yellow dye used in textile industry was treated with different quantities of carbon activated dried orange peel for ten days. 0.2, 0.4, 0.6 and 0.8 g quantities of orange peel were tested with 100, 200, 300 and 400 ppm of auramine yellow dye. Increase in orange peel quantity and treatment period caused an increase in the activity of decolourization. Decolourization was the maximum at pH2.

Ultra-high dilutions (UHD) of drugs used in homeopathy are preserved in sugars. How do solid sugars assimilate characteristics of UHDs? This study attempts to answer this question. The three UHDs of Acid fluoric, Acid nitric, and ethanol were mixed with lactose at 1 µL/g and analyzed by thermogravimetry (TG) and differential scanning calorimetry (DSC) to see any change in their crystal water. TG results

κ-theraphotoxin-Cg2a is a 29- residue polypeptide extracted from the venomous glands of the Chinese earth tiger tarantula Chilobrachys guangxiensis. Plethoras of cancers are being associated with irregular functions of potassium ion channels. An extensive understanding of the toxin’s interaction with the voltage-gated potassium channels is of utmost necessity for it to be screened as a potential pharmacological

This study investigated the production of methane using various substrates. Plantain peels, pig dung, poultry droppings, walnut peels/plantain peels and cow blood/wheat waste were all co-digested, charged in digesters (A-E) and allowed to ferment anaerobically for forty-five (45) days within the mesophilic temperature range of 20.0-39.0°. Digester A contained 3.9 Kg of wheat waste/cow blood and 19

Plant mediated synthesis of nanoparticles is a better substitute for chemically synthesized nanoparticles. These nanoparticles facilitate more advantages in cancer treatment. In this study, biosynthesis of gold nanoparticles has been carried out using aqueous extract of Eichhornia crassipes (Mart.) Solms by the hot air-oven method. The effect of variation of plant extract concentration was carried

The damaging effect of consuming fermented Oryza sativa var. glutinosa on Pancreatic Organ. Tuak is one of the alcoholic drinks made using recipes from the ancestors of the Dayak tribe in the West Kalimantan region. Tuak is commonly consumed especially at traditional ceremonies and holidays. Some studies report that consuming alcoholic drinks negatively impacts health. This study aimed to examine the

Worldwide, marine crustacean waste is a major problem for environmental pollution, and it is a severe risk to the coastline area. Shellfish wastes consist of some commercially valuable products, mainly the chitin. The extraction of chitin from the shellfish waste is very complicated and required a successive pretreatment process. Sonication can improve the process of extraction of chitin from the shrimp

This paper analyses COVID-19 research papers in international collaboration by Indian researchers indexed in the web of Science core collection database through co-authorship. Indian researchers have published 290 publications out of which 128 (44.14%) were in international collaboration. The papers in international collaboration have received 63.19% of total citations as compared to 36.80% received

The world at present is facing a gravest health crisis due to the Covid-19 pandemic. To control its unimaginable transmission worldwide lockdown was implemented resulting in economic deterioration but on the other hand betterment of the environment took place. Therefore this study attempted to analyze the quality of air during the lockdown period and infer its outcome to environment and health. 15

Carboxyl-functionalized graphene oxide (GO-COOH) and amino-functionalized graphene oxide (GO-NH2) were prepared for use as carriers for α-amylase immobilization with 2-3% glutaraldehyde as a coupling agent. The α-amylase immobilized onto modified GO exhibited shifts in both working optimum pH and temperature with an increase from pH 6.0 to pH 7.0, and increased optimum temperature by 5-10℃ compared

Alcoholic liver disease (ALD) is one of the leading causes of death due to cirrhosis. Dyslipidemia is a common finding in ALD and lipid parameters are shown to be associated with disease severity. However the effect of alcohol drinking pattern on lipid abnormalities is still unclear. Hence this cross sectional study was planned to estimate the serum lipid profile in ALD patients and to determine the

Prior to COVID-19 lockdown in our country, the air around us was highly polluted due to emission of greenhouse gases for over centuries. Melting of glaciers and rising of the sea levels were evidenced as the alarming signs of Global warming. Environmental degradation was observed rapidly due to depletion and exploitation of natural resources like soil, water and air. But there are few changes observed

Cisplatin is widely employed in combating renal cancers. However, a major challenge is the resistance of cisplatin by renal cancer cells. Increased miR-222 expression is known to promote this resistance and so ways of downregulating the expression of miR-222 is widely sought after as a means of combating the resistance. The study was performed to explore the effects of miR-222 on cisplatin resistance

miRNAs have been identified to play a crucial role in carcinogenesis through their binding to various regulatory proteins. One such causative molecule identified as miRNA155, which when overexpressed is responsible for carcinogenesis and also leads to telomere fragility. miRNA155 levels in the blood are used for early screening of cancer. Several anticancer drugs such as doxorubicin have been identified

The burden of the management of problematic skin wounds characterized by a compromised skin barrier is growing rapidly. There is an urgent requirement for efficient mechanism-based treatments and more efficacious drug delivery systems. The present study was aimed to examine the wound healing potential of Juglans regia L. root (JR) in rats by incision and excision wound methods via the anti-inflammatory

In the present study, the total antioxidant activity, the total phenolic content, and the antimicrobial activity of methanol extracts obtained from the female cones of Pinus brutia, Pinus nigra, Cupressus sempervirens L., Thuja orientalis L., and Cedrus libani were evaluated. The in vitro total phenolic content, the antioxidant, and the antimicrobial activities were determined using the Folin-Ciocalteu

The aim of this study was to describe the compositional changes in the archaeological specimen using FTIR. Fourier deconvolution was applied in the carbonate (500-650 cm−1), phosphate (900-1200 cm−1), and in the amide region (1700-1600 cm−1). The deconvolution of the spectra in the phosphate region 1200-900 cm−1 reveals six components 960 cm−1, 1010 cm−1, 1020 cm−1, 1030 cm−1, 1110 cm−1 and 1120 cm−1

Sucrose/H+ Symporters (SUTs) play an important role in plant growth and yield. They are involved in long distance transport of sucrose from source leaves to filling grains of cereals through a process called phloem loading. However, the molecular mechanism of sucrose transport through SUTs is not yet known. Understanding the key residues involved in sucrose transport can be helpful in developing high

Hydrocarbon contamination in the environment today is gaining more importance as they are carcinogenic and neurotoxic. Methods to degrade these hydrocarbons are rightfully demanding and researchers are on a lookout for new and indigenous species as they are sustained in that niche by utilizing the resources available. Because of the capabilities exhibited by bacteria in environmental remediation, this

The mechanism of fluorescence quenching of the product S in the presence of captopril was studied. The maximum emission wavelength of the product S was at 405 nm with the excitation wavelength at 316 nm. It was found that the fluorescence quenching of product S was of a static one and the binding constant (K) was 9.29 × 106 J mol-1. A linear relationship was found between the relative fluorescence

Alginates from brown algae are biopolymers, recently being used in various fields such as medical implants, food packaging, etc. The non toxicity, biodegradability, and biocompatibility of these alginates makes them an excellent candidate that be exploited to meet different applications. Through this paper, we are incorporating monolayer of molybdenum disulphide into the matrix of alginic acid from

In this paper we attempt to identify the coverage of publication on SARS-CoV-2 (COVID-19) in different academic databases. Analysis of Indian publications in Dimension has been carried out to identify the authors, institutions, keywords, and journals. Dimension indexes from India 742 publications with 196 citations as on 11th May 2020. All India Insitute of Medical Sciences is the most productive organization

We found that hyperactivation of cytoplasmic (anti-inflammatory) and mitochondrial (pro-inflammatory) arginase isoforms in peripheral blood leukocytes (PBL) is more pronounced in women than in male patients with type 1 diabetes mellitus (T1DM) who received insulin for one year, especially in adolescents young adults 15 years old (12.0 - 25.0) compared with children/adolescents 9.3 years old (4.5-11

The use of efficient strain of Rhizobium is of prime importance for optimum N2 harvest through legumes. The present investigation on microsymbiont associated with root nodulation of Acacia mangium L., an important forest species having wider adaptability. Certain biochemical and molecular techniques were used to characterize the microsymbiont. The 16S rRNA sequence was submitted to NCBI (National Center

The bark of Terminilia Arjuna is known for its numerous health benefits in traditional system of medicine. Nanotechnology based delivery system have added advantages of action at targeted location and improved cellular uptake. In the present paper, polymeric nanoparticles of methanolic extract of Terminilia Arjuna (Arjun ki chhal) were synthesized by using solvent evaporation method. The synthesized

The recent pandemic by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing Coronavirus disease-2019 (COVID-19) affects mainly adults and to a lesser extent children. The major route of spread is via droplets where the virus is released into the air in the form of droplets by an infected individual during coughing and sneezing. Virus primarily infects the respiratory tract epithelium

Glycated hemoglobin is the frequently used test in the diagnosis of diabetes mellitus. However, because this test is affected by various factors and may not be accurate for patients of certain health conditions, the present study aims to explore the association between potential and cost-effective markers like serum Fructosamine, Erythrocyte Na+-K+ ATPase, and Glutathione peroxidase with altering levels

Parkinson’s disease (PD) is a common neurodegenerative disease. Motor symptoms of rigidity, tremor, and bradykinesia and non-motor symptoms like the cognitive deficit, autonomic dysfunction, dementia, anxiety and depression all contribute to morbidity. Emerging shreds of evidence suggest the role of BDNF (Val66Met) polymorphism in PD risk and associated cognitive deficit. Hence, the current study is

Lead is a well-known environmental pollutant due to its widespread industrial uses and persistent nature. Studies have underlined the toxicities caused due to occupational exposure to lead and have also reported the association of blood lead levels (BLL) with Vitamin D Receptor (VDR) gene polymorphism; however, such data is scarce from India. This maiden attempt aims to investigate the association

Levodopa (LD) is the gold standard for the treatment of Parkinson’s disease (PD). Genetic polymorphisms in the SLC6A3 gene (Solute carrier family 6 member 3/DAT-Dopamine Transporter gene) are shown to have a functional impact on levodopa therapeutic response, motor complications of PD and adverse events. Hence the present study was carried out to investigate the association of SLC6A3 polymorphisms

This gender-independent detection of cell-free fetal DNA in maternal plasma using RASSF1A/β-actin has curtained off a new dimension regarding its utility to predict the adverse pregnancy outcomes. Recent efforts have been directed at developing sequences from cell-free fetal DNA (cffDNA) as markers for pregnancy outcomes. The utility of cffDNA using the methylation-dependent DSCR3 and RASSF1A markers

Curcumin is the active component of the Indian spice turmeric, known since ancient times for medicinal properties. Extensive research in the last two to three decades has confirmed its promising pharmacological properties such as anti-cancer, anti-oxidant, anti-inflammatory etc., leading to several ongoing/completed clinical trials. Curcumin has three reactive functional groups: one diketone moiety

Grape extracts of different cultivars (Flame seedless, Kishmish chorni, Red globe and Thompson seedless) were investigated for in vitro antioxidant activity by ABTS assay, and compared protective efficacy against radiation-induced DNA damage. Seed extract showed the highest scavenging activity, followed by skin extract. Among different cultivars, ‘flame seedless’ skin extract showed higher scavenging

Hypothyroidism a quite common thyroid disorder is often associated with anemia. Osmotic fragility is altered with an alteration of the thyroid profile. Hypothyroidism induced reduction of membrane cholesterol and compromised the activity of Na+K+ATPase and increased peroxidation of membrane lipids appear to be responsible for damaging the red blood corpuscle (RBC) membranes which alter the permeability

Inflammation- induced systemic stress plays an essential role in neoplastic progression. Chronic exposure to chemical carcinogens can induce persistent inflammatory changes which further augment loss in physiological hormesis of an organism thereby favouring carcinogenesis. The present study investigated the role of inflammation and associated systemic stress in the development of cervical carcinoma

Women who have had premenopausal total hysterectomy at a young age could probably experience partial or total loss of ovarian function. The purpose of this retrospective cross-sectional study is to investigate the ovarian function in women underwent hysterectomy at an early age. A total of 1165 subjects comprised of 685 hysterectomised women and 480 age matched controls were enrolled in the study.

The uses of metallic nanoparticles have gained importance as one of the therapeutic options to treat infections. Here, we synthesized stable copper nanoparticles (CuNPs) using Thiosalicylic acid and assessed their antimicrobial activities against various Gram-negative bacteria. The synthesized CuNPs had absorption maxima of 570 nM with a size range of 5-11 nM and face-centred cubic (Fcc) crystal structure

Development of acquired chemoresistance renders a challenge in breast cancer therapy. Aurora kinases, a family of serine/threonine mitotic kinases play pivotal roles in the acquirement of chemoresistance. Aurora A is intricately associated with mitotic events and is overexpressed in different cancers including breast cancer. Amplification or overexpression Aurora A confers chemoresistance and are considered