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Remodeling of Cross-bridges Controls Peptidoglycan Cross-linking Levels in Bacterial Cell Walls ACS Chem. Biol. (IF 4.374) Pub Date : 2020-04-03 Alexis J. Apostolos; Sean E. Pidgeon; Marcos M. Pires
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Characterization of Tailoring Steps of Nargenicin A1 Biosynthesis Reveals a Novel Analogue with Anticancer Activities ACS Chem. Biol. (IF 4.374) Pub Date : 2020-04-03 Dipesh Dhakal; Jang Mi Han; Ravindra Mishra; Ramesh Prasad Pandey; Tae-Su Kim; Vijay Rayamajhi; Hye Jin Jung; Tokutaro Yamaguchi; Jae Kyung Sohng
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Development and Characterization of Mouse Monoclonal Antibodies Specific for Clostridiodes (Clostridium) difficile Lipoteichoic Acid ACS Chem. Biol. (IF 4.374) Pub Date : 2020-04-01 Chantelle M. Cairns; Henk van Faassen; Frank St. Michael; Annie Aubry; Kevin A. Henry; Martin A. Rossotti; Susan M. Logan; Greg Hussack; Nicolas Gisch; Wouter F. J. Hogendorf; Christian M. Pedersen; Andrew D. Cox
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Fighting the Coronavirus Outbreak ACS Chem. Biol. (IF 4.374) Pub Date : 2020-04-01 Laura Kiessling; Peng Chen; Jie Wang; Jie P. Li
This article is made available for a limited time sponsored by ACS under the ACS Free to Read License, which permits copying and redistribution of the article for non-commercial scholarly purposes. Figure 1. Remdesivir can be metabolized into its active form GS-441524 and target RdRp of coronavirus. (The picture of RdRp is regenerated from the structure of SARS-CoV nsp12 polymerase, PDB: 6NUS.) Figure
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A Fasciclin Protein Is Essential for Laccase-Mediated Selective Phenol Coupling in Sporandol Biosynthesis ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-31 Wiebke Thiele; Sebastian Obermaier; Michael Müller
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CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from Streptomyces canus ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-30 Chen Zhang; Mohammad R. Seyedsayamdost
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Circular Permutation of the Native Enzyme-Mediated Cyclization Position in Cyclotides ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-30 Bronwyn J. Smithies; Yen-Hua Huang; Mark A. Jackson; Kuok Yap; Edward K. Gilding; Karen S. Harris; Marilyn A. Anderson; David J. Craik
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Vancomycin Derivative Inactivates Carbapenem-Resistant Acinetobacter baumannii and Induces Autophagy ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-27 Paramita Sarkar; Sandip Samaddar; Veena Ammanathan; Venkateswarlu Yarlagadda; Chandradhish Ghosh; Manjulika Shukla; Grace Kaul; Ravi Manjithaya; Sidharth Chopra; Jayanta Haldar
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Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-26 Jintong Zhou; Li Zheng; Zhoufei Hei; Wei Li; Jing Wang; Biao Yu; Pengfei Fang
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Development of Ratiometric Bioluminescent Sensors for in Vivo Detection of Bacterial Signaling ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-25 Andrew B. Dippel; Wyatt A. Anderson; Jin Hwan Park; Fitnat H. Yildiz; Ming C. Hammond
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Stable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-25 Mira Flasch; Christoph Bueschl; Lydia Woelflingseder; Heidi E. Schwartz-Zimmermann; Gerhard Adam; Rainer Schuhmacher; Doris Marko; Benedikt Warth
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A New Docking Domain Type in the Peptide-Antimicrobial-Xenorhabdus Peptide Producing Nonribosomal Peptide Synthetase from Xenorhabdus bovienii ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-25 Jonas Watzel; Carolin Hacker; Elke Duchardt-Ferner; Helge B. Bode; Jens Wöhnert
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Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-23 Michael D. Olp; Daniel J. Sprague; Christopher J. Goetz; Stefan G. Kathman; Sarah L. Wynia-Smith; Shifali Shishodia; Steven B. Summers; Ziyang Xu; Alexander V. Statsyuk; Brian C. Smith
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Revised Structure of Anthelvencin A and Characterization of the Anthelvencin Biosynthetic Gene Cluster ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-23 Céline Aubry; Paolo Clerici; Claude Gerbaud; Laurent Micouin; Jean-Luc Pernodet; Sylvie Lautru
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Designer Palmitoylation Motif-Based Self-Localizing Ligand for Sustained Control of Protein Localization in Living Cells and Caenorhabditis elegans ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-20 Akinobu Nakamura; Choji Oki; Shunsuke Sawada; Tatsuyuki Yoshii; Keiko Kuwata; Andrew K. Rudd; Neal K. Devaraj; Kentaro Noma; Shinya Tsukiji
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Engineering Orthogonal, Plasma Membrane-Specific SLIPT Systems for Multiplexed Chemical Control of Signaling Pathways in Living Single Cells ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-20 Akinobu Nakamura; Choji Oki; Kenya Kato; Satoko Fujinuma; Gembu Maryu; Keiko Kuwata; Tatsuyuki Yoshii; Michiyuki Matsuda; Kazuhiro Aoki; Shinya Tsukiji
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Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-20 Leire Iralde-Lorente; Giusy Tassone; Letizia Clementi; Lorenzo Franci; Claire C Munier; Ylenia Cau; Mattia Mori; Mario Chiariello; Adriano Angelucci; Matthew W. D. Perry; Cecilia Pozzi; Stefano Mangani; Maurizio Botta
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A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5 ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-20 Thomas Hanke; Jong Fu Wong; Benedict-Tilman Berger; Ismahan Abdi; Lena Marie Berger; Roberta Tesch; Claudia Tredup; Alex N. Bullock; Susanne Müller; Stefan Knapp
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Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-20 Stefan G. Kathman; Julia Boshart; Hui Jing; Benjamin F. Cravatt
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3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-20 Luís A. R. Carvalho; Vanessa T. Almeida; José A. Brito; Kenneth M. Lum; Tânia F. Oliveira; Rita C. Guedes; Lídia M. Gonçalves; Susana D. Lucas; Benjamin F. Cravatt; Margarida Archer; Rui Moreira
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Harnessing β-Lactam Antibiotics for Illumination of the Activity of Penicillin-Binding Proteins in Bacillus subtilis ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-20 Shabnam Sharifzadeh; Felix Dempwolff; Daniel B. Kearns; Erin E. Carlson
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Biosynthetic Incorporation of Site-Specific Isotopes in β-Lactam Antibiotics Enables Biophysical Studies ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-20 Jacek Kozuch; Samuel H. Schneider; Steven G. Boxer
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Cell-Based Ligand Discovery for the ENL YEATS Domain ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-19 Joshua N. Asiaban; Natalia Milosevich; Emily Chen; Timothy R. Bishop; Justin Wang; Yuxiang Zhang; Christopher J. Ackerman; Eric N. Hampton; Travis S. Young; Mitchell V. Hull; Benjamin F. Cravatt; Michael A. Erb
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Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule–Deglycobleomycin Conjugate ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-18 Alicia J. Angelbello; Mary E. DeFeo; Christopher M. Glinkerman; Dale L. Boger; Matthew D. Disney
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Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-18 Ashley C. Campbell; Donald F. Becker; Kent S. Gates; John J. Tanner
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Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-13 Qing Li; Chingshen Chan; Norman Peterson; Richard N. Hanna; Alex Alfaro; Kevin L. Allen; Herren Wu; William F. Dall’Acqua; M. Jack Borrok; Jose Luis Santos
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The O-GlcNAc Modification on Kinases ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-10 Paul A. Schwein; Christina M. Woo
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Studies of Thioamide Effects on Serine Protease Activity Enable Two-Site Stabilization of Cancer Imaging Peptides ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-06 Taylor M. Barrett; Xing S. Chen; Chunxiao Liu; Sam Giannakoulias; Hoang Anh T. Phan; Jieliang Wang; E. Keith Keenan; Richard J. Karpowicz, Jr.; E. James Petersson
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Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-24 Tyler D Huber,Jonathan A Clinger,Yang Liu,Weijun Xu,Mitchell D Miller,George N Phillips,Jon S Thorson
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Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-02 Daniel H Ramirez,Chanat Aonbangkhen,Hung-Yi Wu,Jeffrey A Naftaly,Stephanie Tang,Timothy R O'Meara,Christina M Woo
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Off-Loading Mechanism of Products in Polyunsaturated Fatty Acid Synthases. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-27 Shohei Hayashi,Yasushi Ogasawara,Yasuharu Satoh,Chitose Maruyama,Yoshimitsu Hamano,Tohru Dairi
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Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-03-02 Rajiv Kumar Bedi,Danzhi Huang,Lars Wiedmer,Yaozong Li,Aymeric Dolbois,Justyna Aleksandra Wojdyla,May Elizabeth Sharpe,Amedeo Caflisch,Pawel Sledz
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Translation of Microbiota Short-Chain Fatty Acid Mechanisms Affords Anti-infective Acyl-Salicylic Acid Derivatives. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-24 Xinglin Yang,Emily R Forster,Narek Darabedian,Alexander T Kim,Matthew R Pratt,Aimee Shen,Howard C Hang
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A Fluorescent Teixobactin Analogue. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-26 Michael A Morris,Melody Malek,Mohammad H Hashemian,Betty T Nguyen,Sylvie Manuse,Kim Lewis,James S Nowick
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Molecular Networking and Whole-Genome Analysis Aid Discovery of an Angucycline That Inactivates mTORC1/C2 and Induces Programmed Cell Death. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-14 Vipin Mohan Dan,Vinodh J S,Sandesh C J,Rahul Sanawar,Asha Lekshmi,R Ajay Kumar,T R Santhosh Kumar,Uday Kiran Marelli,Syed G Dastager,M Radhakrishna Pillai
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Mechanistic Studies of Bioorthogonal ATP Analogues for Assessment of Histidine Kinase Autophosphorylation. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-11 Adeline Espinasse,Xuelan Wen,Jason D Goodpaster,Erin E Carlson
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Targeted Covalent Inhibition of Telomerase ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-24 Rick C. Betori; Yue Liu; Rama K. Mishra; Scott B. Cohen; Stephen J. Kron; Karl A. Scheidt
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Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-24 Xiaodan Zhang; Lulu Jiang; Ke Huang; Chuantao Fang; Jian Li; Jintong Yang; Huiti Li; Xiaoxue Ruan; Penghui Wang; Mingguang Mo; Ping Wu; Yanhui Xu; Chao Peng; Motonari Uesugi; Deyong Ye; Fa-Xing Yu; Lu Zhou
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Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-21 Matthias R Bauer,Andreas Krämer,Giovanni Settanni,Rhiannon N Jones,Xiaomin Ni,Raysa Khan Tareque,Alan R Fersht,John Spencer,Andreas C Joerger
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C-Mannosyl Lysine for Solid Phase Assembly of Mannosylated Peptide Conjugate Cancer Vaccines. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-11 Tim P Hogervorst,R J Eveline Li,Laura Marino,Sven C M Bruijns,Nico J Meeuwenoord,Dmitri V Filippov,Herman S Overkleeft,Gijsbert A van der Marel,Sandra J van Vliet,Yvette van Kooyk,Jeroen D C Codée
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Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-19 Steffen Glöckner,Khang Ngo,Christoph P Sager,Tobias Hüfner-Wulsdorf,Andreas Heine,Gerhard Klebe
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Splice Modulation Synergizes Cell Cycle Inhibition. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-01-31 Kelsey A Trieger,James J La Clair,Michael D Burkart
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Chemoenzymatic Semisynthesis of Phosphorylated α-Synuclein Enables Identification of a Bidirectional Effect on Fibril Formation. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-17 Buyan Pan,Elizabeth Rhoades,E James Petersson
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Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-14 Simon J Mountford,Bethany M Anderson,Bangyan Xu,Elean S V Tay,Monika Szabo,My-Linh Hoang,Jiayin Diao,Luigi Aurelio,Rhiannon I Campden,Erik Lindström,Erica K Sloan,Robin M Yates,Nigel W Bunnett,Philip E Thompson,Laura E Edgington-Mitchell
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Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-14 April L Lukowski,Leena Mallik,Meagan E Hinze,Brian M Carlson,Duncan C Ellinwood,Joshua B Pyser,Markos Koutmos,Alison R H Narayan
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A Canstatin-Derived Peptide Provides Insight into the Role of Capillary Morphogenesis Gene 2 in Angiogenic Regulation and Matrix Uptake. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-01-31 Jordan G Finnell,Tsz-Ming Tsang,Lorna Cryan,Samuel Garrard,Sai-Lun Lee,P Christine Ackroyd,Michael S Rogers,Kenneth A Christensen
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Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-13 Patrick Ernst,Franziska Zosel,Christian Reichen,Daniel Nettels,Benjamin Schuler,Andreas Plückthun
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Creation of (R)-Amine Transaminase Activity within an α-Amino Acid Transaminase Scaffold. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-11 Moritz Voss,Chao Xiang,Jérémy Esque,Alberto Nobili,Marian J Menke,Isabelle André,Matthias Höhne,Uwe T Bornscheuer
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Fluorescence Assessment of the AmpR-Signaling Network of Pseudomonas aeruginosa to Exposure to β-Lactam Antibiotics. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-10 David A Dik,Choon Kim,Chinedu S Madukoma,Jed F Fisher,Joshua D Shrout,Shahriar Mobashery
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Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-10 Ryan T Howard,Paul Hemsley,Philip Petteruti,Charlie N Saunders,Javier A Molina Bermejo,James S Scott,Jeffrey W Johannes,Edward W Tate
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Efficient Site-Specific Prokaryotic and Eukaryotic Incorporation of Halotyrosine Amino Acids into Proteins. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-01-29 Hyo Sang Jang,Xiaodong Gu,Richard B Cooley,Joseph J Porter,Rachel L Henson,Taylor Willi,Joseph A DiDonato,Stanley L Hazen,Ryan A Mehl
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A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-06 Paul D Walker,Matthew T Rowe,Ashley J Winter,Angus N M Weir,Nahida Akter,Luoyi Wang,Paul R Race,Christopher Williams,Zhongshu Song,Thomas J Simpson,Christine L Willis,Matthew P Crump
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The Kinetic and Molecular Basis for the Interaction of LexA and Activated RecA Revealed by a Fluorescent Amino Acid Probe. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-05 Zachary M Hostetler,Michael B Cory,Chloe M Jones,E James Petersson,Rahul M Kohli
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Characterization of Arylalkylamine N-Acyltransferase from Tribolium castaneum: An Investigation into a Potential Next-Generation Insecticide Target. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-03 Brian G O'Flynn,Eric M Lewandowski,Karin Claire Prins,Gabriela Suarez,Angelica N McCaskey,Nasha M Rios-Guzman,Ryan L Anderson,Britney A Shepherd,Ioannis Gelis,James W Leahy,Yu Chen,David J Merkler
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A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-01-21 Jennifer J Schmidt,Yogan Khatri,Scott I Brody,Catherine Zhu,Halina Pietraszkiewicz,Frederick A Valeriote,David H Sherman
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Identification of Interferon Receptor IFNAR2 As a Novel HCV Entry Factor by Using Chemical Probes. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-02-03 Jie Qing,Ming Wu,Rui Luo,Jizheng Chen,Lin Cao,Debin Zeng,Luqing Shang,Junxiu Nong,Qinkai Wu,Bi-Sen Ding,Xinwen Chen,Zihe Rao,Lei Liu,Zhiyong Lou
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A Multimodal Ca(II) Responsive Near IR-MR Contrast Agent Exhibiting High Cellular Uptake. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-01-30 Casey J Adams,Ruby Krueger,Thomas J Meade
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Design of Organo-Peptides As Bipartite PCSK9 Antagonists. ACS Chem. Biol. (IF 4.374) Pub Date : 2020-01-30 Daniel J Burdick,Nicholas J Skelton,Mark Ultsch,Maureen H Beresini,Charles Eigenbrot,Wei Li,Yingnan Zhang,Huy Nguyen,Monica Kong-Beltran,John G Quinn,Daniel Kirchhofer
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