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Development of a Non-IgG PD-1/PD-L1 Inhibitor by in Silico Mutagenesis and an In-Cell Protein–Protein Interaction Assay ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-15 Boyang Ning; Xueli Ren; Kyoji Hagiwara; Shinji Takeoka; Yoshihiro Ito; Hideyuki Miyatake
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ACS Chemical Biology Special Issue on Epigenetics – Call for Papers ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-15 Laura L. Kiessling
Insight into the epigenetic regulation of gene expression has deepened our understanding of development, homeostasis, and disease. Rapid progress has yielded new tools and methods to probe and monitor epigenetic modifications and transformed our understanding of the underlying molecular mechanisms. In 2016, we joined with ACS Medicinal Chemistry Letters, Biochemistry, and the Journal of Medicinal Chemistry
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Introducing Our Authors ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-15 Julie R. Jones
This article has not yet been cited by other publications.
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Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in Clostridium perfringens ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-22 David R. Jackson; Chelsi D. Cassilly; Damian R. Plichta; Hera Vlamakis; Hualan Liu; Stephen B. Melville; Ramnik J. Xavier; Jon Clardy
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Comparison of N-Acetyl-Glucosamine to Other Monosaccharides Reveals Structural Differences for the Inhibition of α-Synuclein Aggregation ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-05 Ana Galesic; Ananya Rakshit; Giuliano Cutolo; Ricardo Palos Pacheco; Aaron T. Balana; Stuart P. Moon; Matthew R. Pratt
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Use of Synthetic Glycolipids to Probe the Number and Position of Arabinan Chains on Mycobacterial Arabinogalactan ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-31 Shiva Kumar Angala; Maju Joe; Michael R. McNeil; Avraham Liav; Todd L. Lowary; Mary Jackson
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Harnessing Ionic Selectivity in Acetyltransferase Chemoproteomic Probes ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-29 Yihang Jing; Jose L. Montano; Michaella Levy; Jeffrey E. Lopez; Pei-Pei Kung; Paul Richardson; Krzysztof Krajewski; Laurence Florens; Michael P. Washburn; Jordan L. Meier
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Combining Rational Design and Continuous Evolution on Minimalist Proteins That Target the E-box DNA Site ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-28 Ichiro Inamoto; Inder Sheoran; Serban C. Popa; Montdher Hussain; Jumi A. Shin
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Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively induced DNA Base Lesions ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-17 Melis Kant; Yu-ki Tahara; Pawel Jaruga; Erdem Coskun; R. Stephen Lloyd; Eric T. Kool; Miral Dizdaroglu
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A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-22 Daniel A. Jacome; Justin D. Northrup; Andrew J. Ruff; Sean W. Reilly; Iris K. Lee; Gabrielle S. Blizard; Mark A. Sellmyer
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Identification of N-Terminally Diversified GLP-1R Agonists Using Saturation Mutagenesis and Chemical Design ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-14 Chelsea K. Longwell; Stephanie Hanna; Nina Hartrampf; R. Andres Parra Sperberg; Po-Ssu Huang; Bradley L. Pentelute; Jennifer R. Cochran
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Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF3) ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-14 Arseniy Butrin; Brett A. Beaupre; Noel Kadamandla; Peidong Zhao; Sida Shen; Richard B. Silverman; Graham R. Moran; Dali Liu
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Base Pairing and Functional Insights into N3-Methylcytidine (m3C) in RNA ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-17 Song Mao; Phensinee Haruehanroengra; Srivathsan V. Ranganathan; Fusheng Shen; Thomas J. Begley; Jia Sheng
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l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-18 Prasanth Kumar; Anthony Meza; Jonathan M. Ellis; Grace A. Carlson; Craig A. Bingman; Andrew R. Buller
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PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-14 Cheng-Jian Zheng; Edward Kalkreuter; Bo-Yi Fan; Yu-Chen Liu; Liao-Bin Dong; Ben Shen
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Spatial Distribution of Transcytosis Relevant Phospholipids in Response to Omega-3 Dietary Deprivation ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-14 Amanda R. Clark; Elizabeth C. Randall; Begoña G. C. Lopez; Michael S. Regan; Jeffrey N. Agar; Benjamin J. Andreone; Chenghua Gu; Nathalie Y. R. Agar
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Branched Chain Lipid Metabolism As a Determinant of the N-Acyl Variation of Streptomyces Natural Products ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-07 Neil P. J. Price; Michael A. Jackson; Trina M. Hartman; Gisela Brändén; Margareta Ek; Aaron A. Koch; Paul D. Kennedy
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Structural and Biosynthetic Analysis of the Fabrubactins, Unusual Siderophores from Agrobacterium fabrum Strain C58 ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-29 Vladimir Vinnik; Fan Zhang; Hyunjun Park; Taylor B. Cook; Kurt Throckmorton; Brian F. Pfleger; Tim S. Bugni; Michael G. Thomas
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Characterization of an Antibacterial Agent Targeting Ferrous Iron Transport Protein FeoB against Staphylococcus aureus and Gram-Positive Bacteria ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-30 Minhye Shin; Yerin Jin; Jinsub Park; Daye Mun; Soo Rin Kim; Shelley M. Payne; Kyoung Heon Kim; Younghoon Kim
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Sixteen Different Types of Lipid-Conjugated siRNAs Containing Saturated and Unsaturated Fatty Acids and Exhibiting Enhanced RNAi Potency ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-21 Takanori Kubo; Yoshio Nishimura; Yuichiro Sato; Kazuyoshi Yanagihara; Toshio Seyama
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Semiprocessive Hyperglycosylation of Adhesin by Bacterial Protein N-Glycosyltransferases ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-05 Liubov Yakovlieva; Carlos Ramírez-Palacios; Siewert J. Marrink; Marthe T. C. Walvoort
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Diverse Impacts on Prokaryotic and Eukaryotic Membrane Activities from Hydrophobic Subunit Variation Among Nylon-3 Copolymers ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-11 Leslie A. Rank; Anurag Agrawal; Lei Liu; Yanyu Zhu; Mainak Mustafi; James C. Weisshaar; Samuel H. Gellman
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Prenylation and Dehydrogenation of a C2-Reversely Prenylated Diketopiperazine as a Branching Point in the Biosynthesis of Echinulin Family Alkaloids in Aspergillus ruber ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-31 Jonas Nies; Shu-Ming Li
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HIV-1 Env-Dependent Cell Killing by Bifunctional Small-Molecule/Peptide Conjugates ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-07 Althea Gaffney; Aakansha Nangarlia; Charles G. Ang; Steven Gossert; Adel Ahmed Rashad Ahmed; Md Alamgir Hossain; Cameron F. Abrams; Amos B. Smith, III; Irwin Chaiken
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Exploring the Ligand Preferences of the PHD1 Domain of Histone Demethylase KDM5A Reveals Tolerance for Modifications of the Q5 Residue of Histone 3 ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-14 Sarah E. Anderson; James E. Longbotham; Patrick T. O’Kane; Fatima S. Ugur; Danica Galonić Fujimori; Milan Mrksich
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Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coli ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-11 Nancy Wiebelhaus; Jacqueline M. Zaengle-Barone; Kevin K. Hwang; Katherine J. Franz; Michael C. Fitzgerald
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High Throughput Screen Identifies Small Molecule Effectors That Modulate Thin Filament Activation in Cardiac Muscle ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-14 Priyanka Parijat; Laszlo Kondacs; Alexander Alexandrovich; Mathias Gautel; Alexander J. A. Cobb; Thomas Kampourakis
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Correction to Efficient Site-Specific Prokaryotic and Eukaryotic Incorporation of Halotyrosine Amino Acids into Proteins ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-31 Hyo Sang Jang; Xiaodong Gu; Richard B. Cooley; Joseph J. Porter; Rachel L. Henson; Taylor Willi; Joseph A. DiDonato; Stanley L. Hazen; Ryan A. Mehl
During deposition into Addgene, additional off-target mutations in the Mb haloTyr C6 aaRS were identified at sites 13, 82, and 265. Table 1 and Figure 1 report the correct sequence information for the functional aaRS’s used in bacterial and eukaryotic expression systems. Functional plasmids are now available from Addgene (numbers are listed in Table 1). Figure 1 contains the corrected sequences for
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Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-13 Marcin Warminski; Joanna Kowalska; Elzbieta Nowak; Dorota Kubacka; Ryan Tibble; Renata Kasprzyk; Pawel J. Sikorski; John D. Gross; Marcin Nowotny; Jacek Jemielity
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Homobivalent Dopamine D2 Receptor Ligands Modulate the Dynamic Equilibrium of D2 Monomers and Homo- and Heterodimers ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-12 Tamara Ullmann; Marie Gienger; Julian Budzinski; Jan Hellmann; Harald Hübner; Peter Gmeiner; Dorothee Weikert
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The Inositol Pyrophosphate Biosynthetic Pathway of Trypanosoma cruzi ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-07 Brian S. Mantilla; Leticia D. Do Amaral; Henning J. Jessen; Roberto Docampo
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Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-07 Roberto Di Blasi; Oleg Blyuss; John F. Timms; Daniel Conole; Francesca Ceroni; Harry J. Whitwell
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m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells ACS Chem. Biol. (IF 4.434) Pub Date : 2021-01-07 Sarah Huff; Shashi Kant Tiwari; Gwendolyn M. Gonzalez; Yinsheng Wang; Tariq M. Rana
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ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-23 Verna Van; Aaron T. Smith
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Inhibition of the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa Using Targeted Sugar Nucleotide Probes ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-25 Laura Beswick; Eleni Dimitriou; Sanaz Ahmadipour; Ayesha Zafar; Martin Rejzek; Jóhannes Reynisson; Robert A. Field; Gavin J. Miller
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Addicting Escherichia coli to New-to-Nature Reactions ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-23 Rudy Rubini; Clemens Mayer
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A Bump-Hole Strategy for Increased Stringency of Cell-Specific Metabolic Labeling of RNA ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-21 Kim Nguyen; Miles Kubota; Jon del Arco; Chao Feng; Monika Singha; Samantha Beasley; Jasmine Sakr; Sunil P. Gandhi; Matthew Blurton-Jones; Jesus Fernández Lucas; Robert C. Spitale
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Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-08 Dimitris Korovesis; Nicole Rufo; Rita Derua; Patrizia Agostinis; Steven H. L. Verhelst
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Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-16 Andrei Ursu; Kye Won Wang; Jessica A. Bush; Shruti Choudhary; Jonathan L. Chen; Jared T. Baisden; Yong-Jie Zhang; Tania F. Gendron; Leonard Petrucelli; Ilyas Yildirim; Matthew D. Disney
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Nucleosome Dynamics during Transcription Elongation ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-02 Mai T. Huynh; Satya P. Yadav; Joseph C. Reese; Tae-Hee Lee
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Fluorescence Anisotropy-Based Tethering for Discovery of Protein–Protein Interaction Stabilizers ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-16 Eline Sijbesma; Bente A. Somsen; Galen P. Miley; Iris A. Leijten-van de Gevel; Luc Brunsveld; Michelle R. Arkin; Christian Ottmann
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Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-18 Mary E Matyskiela; Jinyi Zhu; Joshua M Baughman; Thomas Clayton; Michelle Slade; Hon Kit Wong; Kristina Danga; Xinde Zheng; Mark Labow; Laurie LeBrun; Gang Lu; Philip P Chamberlain; Joel W Thompson
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Conformational Dynamics Contribute to Substrate Selectivity and Catalysis in Human Kynureninase ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-04 Christos S. Karamitros; Kyle Murray; Yusuke Sugiyama; Yoichi Kumada; Kenneth A. Johnson; George Georgiou; Sheena D’Arcy; Everett M. Stone
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Reactivity-Based Screening for Citrulline-Containing Natural Products Reveals a Family of Bacterial Peptidyl Arginine Deiminases ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-29 Lonnie A. Harris; Patricia M. B. Saint-Vincent; Xiaorui Guo; Graham A. Hudson; Adam J. DiCaprio; Lingyang Zhu; Douglas A. Mitchell
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Amide-Linked C4″-Saccharide Modification of KRN7000 Provides Potent Stimulation of Human Invariant NKT Cells and Anti-Tumor Immunity in a Humanized Mouse Model ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-09 Noemi Alejandra Saavedra-Avila; Santosh Keshipeddy; Matthew J. Guberman-Pfeffer; Ayax Pérez-Gallegos; Neeraj K. Saini; Carolina Schäfer; Leandro J. Carreño; José A Gascón; Steven A. Porcelli; Amy R. Howell
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Multi-Institution Research and Education Collaboration Identifies New Antimicrobial Compounds ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-26 Amelia A. Fuller; Amy B. Dounay; Douglas Schirch; Daniel G. Rivera; Karl A. Hansford; Alysha G. Elliott; Johannes Zuegg; Matthew A Cooper; Mark A. T. Blaskovich; Jacob R. Hitchens; Sarah Burris-Hiday; Kristiana Tenorio; Yanira Mendez; J. Geno Samaritoni; Martin J. O’Donnell; William L. Scott
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N-Linked Glycosylation Prevents Deamidation of Glycopeptide and Glycoprotein ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-03 Hailiang Joshua Zhu; Ding Liu; Vy P. Tran; Zhigang Wu; Kuan Jiang; He Zhu; Jiabin Zhang; Christopher Gibbons; Bingzhong Xue; Hang Shi; Peng George Wang
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Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-25 Anna D. Grabowska; Yoann Brison; Laurent Maveyraud; Sabine Gavalda; Alexandre Faille; Virginie Nahoum; Cécile Bon; Christophe Guilhot; Jean-Denis Pedelacq; Christian Chalut; Lionel Mourey
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Biosynthesis of the Nuclear Factor of Activated T Cells Inhibitor NFAT-133 in Streptomyces pactum ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-07 Wei Zhou; Priyapan Posri; Mostafa E. Abugrain; Alexandra J. Weisberg; Jeff H. Chang; Taifo Mahmud
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Tailored Cofactor Traps for the in Situ Detection of Hemithioacetal-Forming Pyridoxal Kinases ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-03 Ines Hübner; Jan-Niklas Dienemann; Julia Friederich; Sabine Schneider; Stephan A. Sieber
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Biochemical and Structural Investigation of GnnA in the Lipopolysaccharide Biosynthesis Pathway of Acidithiobacillus ferrooxidans ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-17 Juthatip Manissorn; Thassanai Sitthiyotha; Jenny Rose E. Montalban; Surasak Chunsrivirot; Peerapat Thongnuek; Kittikhun Wangkanont
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Controlling the Production of Pseudomonas Phenazines by Modulating the Genetic Repertoire ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-01 Simone Schmitz; Miriam A. Rosenbaum
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Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-24 Yuta Kudo; Takayoshi Awakawa; Yi-Ling Du; Peter A. Jordan; Kaitlin E. Creamer; Paul R. Jensen; Roger G. Linington; Katherine S. Ryan; Bradley S. Moore
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Small Molecule Phenotypic Screen Identifies Novel Regulators of LDLR Expression ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-03 Navasona Krishnan; Xiaoying Chen; Diana Donnelly-Roberts; Eric G. Mohler; David M. Holtzman; Sujatha M. Gopalakrishnan
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Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52 ACS Chem. Biol. (IF 4.434) Pub Date : 2020-12-01 Mengna Ma; Shimeng Guo; Xi Lin; Shanshan Li; Yiran Wu; Yanping Zeng; Youhong Hu; Suwen Zhao; Fei Xu; Xin Xie; Wenqing Shui
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Efficient Preparation and Bioactivity Evaluation of Glycan-Defined Glycoproteins ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-24 Ji Young Hyun; Sanggil Kim; Chang-Hee Lee; Hyun Soo Lee; Injae Shin
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Introducing Our Authors ACS Chem. Biol. (IF 4.434) Pub Date : 2020-11-20 Julie R. Jones
This article has not yet been cited by other publications.
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Single-Cell Activation of the cAMP-Signaling Pathway in 3D Tissues with FRET-Assisted Two-Photon Activation of bPAC ACS Chem. Biol. (IF 4.434) Pub Date : 2020-10-19 Tomoaki Kinjo; Tetsuya Watabe; Kenju Kobachi; Kenta Terai; Michiyuki Matsuda
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An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties ACS Chem. Biol. (IF 4.434) Pub Date : 2020-10-12 Niloufar Mollasalehi; Liberty Francois-Moutal; David D. Scott; Judith A. Tello; Haley Williams; Brendan Mahoney; Jacob M. Carlson; Yue Dong; Xingli Li; Victor G. Miranda; Vijay Gokhale; Wei Wang; Sami J. Barmada; May Khanna
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Genome- and Mass Spectrometry-Guided Discovery of Ralstoamides A and B from Ralstonia solanacearum Species Complex ACS Chem. Biol. (IF 4.434) Pub Date : 2020-10-28 Shoko Komatsu; Chiaki Tsumori; Kouhei Ohnishi; Kenji Kai
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