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Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke ( Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins J. Nat. Med. (IF 2.055) Pub Date : 2021-01-23 Tomoko Matsumoto, Souichi Nakashima, Seikou Nakamura, Yasunao Hattori, Tomoshige Ando, Hisashi Matsuda
The methanolic extract of the leaves of artichoke (Cynara scolymus L.) was found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Among the constituents of the extract, six sesquiterpene lactones (cynaropicrin, grosheimin, 11β,13-dihydrocynaropicrin, 3β-hydroxy-8α-[(S)-3-hydroxy-2-methylpropionyloxy]guaia-4(15),10(14),11(13)-trien-1α,5α,6βH-12,6-olide,
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Triterpenoids from Walsura trichostemon J. Nat. Med. (IF 2.055) Pub Date : 2021-01-22 Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Osamu Shirota, Michiyo Matsuno, Hajime Mizukami, Hiroshi Morita
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Exploration for the real causative agents of licorice-induced pseudoaldosteronism J. Nat. Med. (IF 2.055) Pub Date : 2021-01-22 Toshiaki Makino
I investigated the causative agents of licorice-induced pseudoaldosteronism, which is a frequent side effect of Japanese traditional Kampo medicines. Glycyrrhizin (GL), the main ingredient of licorice, is absorbed after being metabolized to glycyrrhetinic acid (GA) by intestinal bacteria, and then metabolized in liver to 3-monoglucuronyl-glycyrrhetinic acid (3MGA). In normal condition, 3MGA is excreted
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Bisindole alkaloids from Voacanga grandifolia leaves J. Nat. Med. (IF 2.055) Pub Date : 2021-01-19 Alfarius Eko Nugroho, Yurika Ono, Eunji Jin, Yusuke Hirasawa, Toshio Kaneda, Abdul Rahman, Idha Kusumawati, Takahiro Tougan, Toshihiro Horii, Noor Cholies Zaini, Hiroshi Morita
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Ent- kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3β/β-catenin transduction pathway J. Nat. Med. (IF 2.055) Pub Date : 2021-01-08 Yoshiaki Manse, Fenglin Luo, Kazuhiro Kato, Akane Okazaki, Eriko Okada-Nishida, Mitsuhiro Yanagida, Sho Nakamura, Toshio Morikawa
A methanol extract from Isodonis Herba demonstrated significant proliferative effect on human hair follicle dermal papilla cells (HFDPC, % of control: 150.0 ± 2.0% at 20 µg/mL, p < 0.01). From the extract, 14 ent-kaurane-type diterpenoids (1–14), two abietane-type diterpenoids (15 and 16) and four triterpenoids (17–20) were isolated. Among the isolates, enmein (1, 160.9 ± 3.0% at 20 µM, p < 0.01),
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Stilbenoids isolated from the roots of Rheum lhasaense under the guidance of the acetylcholinesterase inhibition activity J. Nat. Med. (IF 2.055) Pub Date : 2021-01-07 Qing Liu, Jie Shen, Pei Li, Yue Li, Chunnian He, Peigen Xiao
Four unknown stilbenoids, including one dimer, namely 4′-methoxy-scirpusin A (5) and three monomeric stilbene glycosides, namely piceatannol-3′-O-[2′′-(3,5-dihydroxy-4-methoxybenzoyl)]-β-d-glucopyranoside (13), piceatannol-3′-O-(2′′-galloyl)-β-d-glucopyranoside (14) and piceatannol-3′-O-(6″-p-coumaroyl)-β-d-glucopyranoside (16) together with 15 described compounds, were isolated from the ethyl acetate
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Complanadine F, a novel dimeric alkaloid from Lycopodium complanatum J. Nat. Med. (IF 2.055) Pub Date : 2021-01-06 Yusuke Hirasawa, Manami Agawa-Kakimoto, Kazumasa Zaima, Nahoko Uchiyama, Yukihiro Goda, Hiroshi Morita
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Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats J. Nat. Med. (IF 2.055) Pub Date : 2021-01-04 Mikina Takiyama, Takashi Matsumoto, Sho Sanechika, Junko Watanabe
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Development and validation of an analysis method for pesticide residues by gas chromatography–tandem mass spectrometry in Daikenchuto J. Nat. Med. (IF 2.055) Pub Date : 2021-01-03 Hirokazu Saegusa, Hiroshi Nomura, Masaki Takao, Takashi Hamaguchi, Masaru Yoshida, Yuzo Kodama
Daikenchuto (DKT) is one of the most widely used “Kampo” in Japan as a representative of herbal medicine. Because DKT is made from a natural product like food, it requires the management of pesticides; therefore, an analysis of residual pesticides in Kampo is required. The World Health Organization (WHO) indicates that pesticide residue analysis by the U.S. Pharmacopeia (USP) is required. USP defines
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Effects of clovamide and its related compounds on the aggregations of amyloid polypeptides J. Nat. Med. (IF 2.055) Pub Date : 2021-01-03 Daigo Nomoto, Tatsuhiko Tsunoda, Hideyuki Shigemori
Alzheimer's disease (AD) and type 2 diabetes (T2D) are common diseases in the elderly, and the increasing number of patients with these diseases has become a serious health problem worldwide. The aggregation and development of plaque of amyloid polypeptides (amyloid β; Aβ and human islet amyloid polypeptide; hIAPP, amylin) are found in the brains of patients with AD and the pancreas of patients with
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One-pot enantioselective synthesis of ( S )-spirobrassinin and non-natural ( S )-methylspirobrassinin from amino acids using a turnip enzyme J. Nat. Med. (IF 2.055) Pub Date : 2021-01-03 Kaori Ryu, Seikou Nakamura, Souichi Nakashima, Hisashi Matsuda
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Sedative effects of l-menthol, d-camphor, phenylethyl alcohol, and geraniol J. Nat. Med. (IF 2.055) Pub Date : 2021-01-02 Tomoko Oshima, Michiho Ito
Various essential oils from plants and fragrance components such as monoterpenes have been discovered to reduce spontaneous movements in mice; thus, it has been made clear that the odor itself has the sedative activity. In the present study, we examined the sedative activity of the odors of fragrance components added to eye drops; l-menthol, d-camphor, phenylethyl alcohol, and geraniol, which are often
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Application of the highly sensitive labeling reagent to the structural confirmation of readily isomerizable peptides J. Nat. Med. (IF 2.055) Pub Date : 2021-01-02 Chengqian Pan, Takefumi Kuranaga, Hideaki Kakeya
Thioamycolamide A (1) is a biosynthetically unique cytotoxic cyclic microbial lipopeptide that bears a d-configured thiazoline, a thioether bridge, a fatty acid side chain, and a reduced C-terminus. It has gained attention for its unique structure, and very recently we reported the total synthesis of 1 via a biomimetic route. The NMR spectra of synthetic 1 agreed with those of natural 1. However, structural
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Genomics-directed activation of cryptic natural product pathways deciphers codes for biosynthesis and molecular function J. Nat. Med. (IF 2.055) Pub Date : 2020-12-03 Yuta Tsunematsu
Natural products, which can be isolated from living organisms worldwide, have played a pivotal role in drug discovery since ancient times. However, it has become more challenging to identify a structurally novel molecule with promising biological activity for pharmaceutical development, mainly due to the limited methodologies for their acquisition. In this review, we summarize our recent studies that
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Amyloid β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus pruinosus J. Nat. Med. (IF 2.055) Pub Date : 2020-11-24 Koji Fujihara, Takuya Shimoyama, Ryo Kawazu, Hiroaki Sasaki, Kiyotaka Koyama, Kunio Takahashi, Kaoru Kinoshita
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Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1 J. Nat. Med. (IF 2.055) Pub Date : 2020-11-20 Shufang Hu, Weihong Zheng, Li Jin
Astragaloside IV (ASV), which has several pharmacological abilities, shows potential therapeutic effects on certain cancers by regulating the expression of long noncoding RNA (lncRNA). However, the anticancer role that ASV plays by regulating lncRNAs in breast cancer remains unknown. In this study, we first demonstrated that the lncRNA of TRHDE antisense RNA 1 (TRHDE-AS1) was downregulated in breast
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Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice J. Nat. Med. (IF 2.055) Pub Date : 2020-11-17 Kenta Murata, Manami Oyama, Misaki Ogata, Nina Fujita, Ryuji Takahashi
This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male HR-1 hairless mice. JHT has been traditionally prescribed for patients presenting skin disorders with redness and swelling, and, in Japan, it is approved for prescription to patients with acute and/or purulent skin disorders, hives, acute eczema, and
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4β-Hydroxywithanolide E and withanolide E from Physalis peruviana L. inhibit adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion J. Nat. Med. (IF 2.055) Pub Date : 2020-11-16 Momochika Kumagai, Izumi Yoshida, Takashi Mishima, Masahiro Ide, Kazuhiro Fujita, Matsumi Doe, Keisuke Nishikawa, Yoshiki Morimoto
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Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway J. Nat. Med. (IF 2.055) Pub Date : 2020-11-13 Meng-Fei An, Ming-Yue Wang, Chang Shen, Ze-Rui Sun, Yun-Li Zhao, Xuan-Jun Wang, Jun Sheng
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Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells J. Nat. Med. (IF 2.055) Pub Date : 2020-11-06 Shinya Okubo, Tomoe Ohta, Hideaki Fujita, Yukihiro Shoyama, Takuhiro Uto
Autophagy is a catabolic process for degradation of intracellular components and plays an important role in the development and growth of cancer. Our preliminary screening confirmed that an extract from the root of Saussurea lappa remarkably suppressed the proliferation of HepG2 hepatocellular carcinoma cells and inhibited autophagy. In this study, we explored the effects of costunolide (CL) and dehydrocostuslactone
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Environmental and soil characteristics in Ephedra habitats of Uzbekistan J. Nat. Med. (IF 2.055) Pub Date : 2020-10-22 Motoyasu Minami, Fujii Taichi, Yukako Honda, Kaoru Ueno, Junichi Shinozaki, Susumu Itoh, Akihito Takano, Jollibekov Berdiyar, Ivan Ivanovich Maltsev, Takahisa Nakane
In Uzbekistan, Ephedra distachya L., E. equisetina Bunge, E. foliata Boiss. ex C. A. Mey., E. lomatolepis Schrenk, and E. strobilacea Bunge show species specificity for habitat environments and physical and chemical characteristics of habitat soils. Furthermore, the relationship between soil characteristics and ephedrine and pseudoephedrine contents was examined. E. distachya was found growing from
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Changes in the extracted amounts and seasonally variable constituents of Diospyros kaki at different growth stages J. Nat. Med. (IF 2.055) Pub Date : 2020-10-21 Emi Katsumi, Naohiro Oshima, Natsuko Kagawa, Hitoshi Ohara, Noriyasu Hada
Persimmon Calyx is a crude drug derived from the persistent calyx of mature fruit of Diospyros kaki Thunberg (Ebenaceae) and is used for the treatment of intractable hiccups. Although there are several reports on the isolation of constituents from Persimmon Calyx, its active constituents have not been elucidated. In this study, by focusing on the medicinal part of Persimmon Calyx, calyx on mature fruit
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Four new pyrrole alkaloids from the rhizomes of Amomum koenigii J. Nat. Med. (IF 2.055) Pub Date : 2020-10-21 Hong Yin, Chao Guo, Jin-Ming Gao
Four new pyrrole alkaloids, named amokoens A–D (1–4), together with three known compounds (5–7) were isolated from the rhizomes of Amomum koenigii. Their structures and absolute configurations were established by spectroscopic data, including 1D and 2D NMR, and the optical rotation calculations. All the isolates were evaluated for their effects on nitric oxide (NO) production in lipopolysaccharide-induced
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Anthraquinone-containing compound in rhubarb prevents indole production via functional changes in gut microbiota J. Nat. Med. (IF 2.055) Pub Date : 2020-10-19 Kento Takayama, Shoji Maehara, Norihiko Tabuchi, Nobuyuki Okamura
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Acacienone, a terpenoid-like natural product having an unprecedented C20 framework isolated from Acacia mangium leaves J. Nat. Med. (IF 2.055) Pub Date : 2020-10-13 Yasumasa Hara, Yuichi Totsugi, Hiroshi Ichikawa, Shinji Harada, Kazuki Fujii, Firoj Ahmed, Samir K. Sadhu, Midori A. Arai, Masami Ishibashi
A novel C20 natural product, acacienone (1), was isolated from the leaves of Acacia mangium collected in Bangladesh. The structure of compound 1 was elucidated by spectral studies and X-ray crystallographic analysis. Acacienone (1) possesses a terpenoid-related tetracyclic framework containing 20 carbons with biogenetically unusual structural features: (i) vicinal C1-branches at the C-3 and C-4 positions
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Epoxyquinophomopsins A and B from endophytic fungus Phomopsis sp. and their activity against tyrosine kinase J. Nat. Med. (IF 2.055) Pub Date : 2020-10-08 Elvira Hermawati, Suzany D. Ellita, Lia D. Juliawaty, Euis H. Hakim, Yana M. Syah, Hayato Ishikawa
Two new quinone derivatives, epoxyquinophomopsins A (1) and B (2), were purified from the EtOAc extract of endophytic fungus Phomopsis sp isolated from Morus cathayana. The structures of both compounds were determined based on 1D and 2D NMR and mass spectral data, as well as by x-ray diffraction analysis for 1. Compounds 1 and 2 were screened against eight receptor- (RTKs) and eight non-receptor tyrosine
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Structure and anticancer activity of a new lectin from the cultivated red alga, Kappaphycus striatus J. Nat. Med. (IF 2.055) Pub Date : 2020-10-06 Le Dinh Hung, Phan Thi Hoai Trinh
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Correction to: Inhibiting reactive oxygen species-dependent autophagy enhanced baicalein-induced apoptosis in oral squamous cell carcinoma J. Nat. Med. (IF 2.055) Pub Date : 2020-10-06 Bo Li, Mei Lu, Xin-Xiang Jiang, Meng‑Xiong Pan, Jun-Wu Mao, Mei Chen
In the original publication of the article, an incorrect immunofluorescence of GFP-LC3 puncta was included in the Fig. 3a. The correct version of Fig. 3a is provided below.
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Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota J. Nat. Med. (IF 2.055) Pub Date : 2020-09-30 Qian Chen, Dongwen Ren, Jiaqi Wu, Haiyang Yu, Xiaopeng Chen, Jia Wang, Yi Zhang, Mengyang Liu, Tao Wang
Inflammation plays a predominant role in the pathogenesis of diabetic kidney disease (DKD). The Shenyan Kangfu tablet (SYKFT) is a prescription of traditional Chinese medicine for treating chronic kidney disease. However, the concrete mechanism is still unclear. According to previous clinical trial, we explored the effects and potential mechanism on DKD in db/db model supplemented with SYKFT. As a
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Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts. J. Nat. Med. (IF 2.055) Pub Date : 2020-09-26 Ximeng Yang,Kaori Nomoto,Chihiro Tohda
Several studies have suggested that some kind of Dioscorea species (yam) or yam-contained herbal medicines have cognitive enhancement effect. However, it has been unknown what is a crucial factor for cognitive enhancement in each Dioscorea species. In this study, we aimed to investigate whether one of the main and brain-penetrating components in yams, diosgenin, can be a novel criterion to assess memory
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Two new rearranged clerodane diterpenes from Thai Tinospora baenzigeri. J. Nat. Med. (IF 2.055) Pub Date : 2020-09-24 Sujitra Hanthanong,Siwattra Choodej,Thammarat Aree,Khanitha Pudhom
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Macrocarquinoids A-C, new meroterpenoids from Sargassum macrocarpum. J. Nat. Med. (IF 2.055) Pub Date : 2020-09-24 Hiromi Niwa,Shin-Ichiro Kurimoto,Takaaki Kubota,Mitsuhiro Sekiguchi
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PTP1B and α-glucosidase inhibitors from Selaginella rolandi-principis and their glucose uptake stimulation. J. Nat. Med. (IF 2.055) Pub Date : 2020-09-14 Dinh-Tuan Nguyen,Dao-Cuong To,Thi-Tuyen Tran,Manh-Hung Tran,Phi-Hung Nguyen
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Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway. J. Nat. Med. (IF 2.055) Pub Date : 2020-08-31 Huankai Yao,Xiuli Zhang,Nan Zhang,Jindong Li,Yan Li,Qunli Wei
Triple negative breast cancer (TNBC) is the most severe type of breast cancer due to the lack of specific targets and rapid metastasis, which result in the poor prognosis. Recently, phosphatidylinositol 3-kinase (PI3K)/Akt pathway has emerged as a potential target for the treatment of TNBC. In our research interest to discover phytochemicals targeting TNBC, we have investigated wikstromol from Wikstroemia
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Solubility enhancement of berberine-baicalin complex by the constituents of Gardenia Fruit. J. Nat. Med. (IF 2.055) Pub Date : 2020-08-28 Kazuki Okoshi,Yoshinori Uekusa,Yuji Narukawa,Fumiyuki Kiuchi
A Kampo prescription usually consists of several crude drugs and contains many kinds of compounds. Physicochemical interactions between the compounds may occur in the process of decoction, by which Kampo prescriptions are usually prepared for ingestion, and the interactions may change the extraction yields of the constituents. Berberine and baicalin have been reported to form precipitates. Orengedokuto
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Correction to: The search for, and chemistry and mechanism of, neurotrophic natural products. J. Nat. Med. (IF 2.055) Pub Date : 2020-08-20 Yoshiyasu Fukuyama,Miwa Kubo,Kenichi Harada
he article The search for, and chemis
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Iridoids isolated from Viticis Fructus inhibit paclitaxel-induced mechanical allodynia in mice. J. Nat. Med. (IF 2.055) Pub Date : 2020-08-20 Huanhuan Yu,Kazufumi Toume,Yoko Kurokawa,Tsugunobu Andoh,Katsuko Komatsu
Chemotherapy-induced peripheral neuropathy (CIPN) manifests as mechanical allodynia and hyperalgesia, and is one of the main adverse effects of chemotherapeutic agents. Currently available therapeutic drugs are not sufficiently effective for the management of this adverse effect in the clinic. Therefore, the development of novel therapeutic agents for treating CIPN is necessary. Our previous study
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Structural revision of sesbagrandiflorains A and B, and synthesis and biological evaluation of 6-methoxy-2-arylbenzofuran derivatives. J. Nat. Med. (IF 2.055) Pub Date : 2020-08-18 Noviany Noviany,Arash Samadi,Evan L Carpenter,Mostafa E Abugrain,Sutopo Hadi,Neny Purwitasari,Gitali Indra,Arup Indra,Taifo Mahmud
Sesbagrandiflorains A (1) and B (2), isolated from the stem bark of the Indonesian fabaceous plant Sesbania grandiflora, were reported to be 6-methoxy-2-(2´,3´-dihydroxy-5´-methoxyphenyl)-1-benzofuran-3-carbaldehyde and 6-hydroxy-2-(2´,3´-dihydroxy-5´-methoxyphenyl)-1-benzofuran-3-carbaldehyde, respectively. However, based on reevaluation of their 1D and 2D NMR data, the chemical structures of 1 and
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Kamiohnoyneosides A and B, two new polyacetylene glycosides from flowers of edible Chrysanthemum "Kamiohno". J. Nat. Med. (IF 2.055) Pub Date : 2020-08-17 Shin-Ichiro Kurimoto,Hiroki Fujita,Satomi Kawaguchi,Yu F Sasaki,Takanori Nakamura,Takaaki Kubota
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New isoflavone glucosides in yabumame (Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica (Oliv.) H.Ohashi) and their effect on leukotriene B4 production in mast cells. J. Nat. Med. (IF 2.055) Pub Date : 2020-08-16 Lifeng Yang,Jyunichi Kirikoshi,Daiki Sato,Mikako Takasugi,Atsuyuki Hishida,Shigeki Hayashi,Nobuo Kawahara,Megumi Mizukami,Maoyu Wu,Takashi Yamagishi,Hirofumi Arai
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Triterpenoids from Celastrus orbiculatus Thunb. inhibit RANKL-induced osteoclast formation and bone resorption via c-Fos signaling. J. Nat. Med. (IF 2.055) Pub Date : 2020-08-10 Thi Oanh Vu,Phuong Thao Tran,Wonyoung Seo,Jeong Hyung Lee,Byung Sun Min,Jeong Ah Kim
Fourteen triterpenes, lup-20(29)-ene-3β,6β-diol (1), betulin (2), lupeol caffeate (3), 3β-caffeoyloxylup-20(29)-en-6α-ol (4), betulin-3β-yl-caffeate (5), 3β-trans-feruloylbetulin (6), betulinaldehyde 3-caffeate (7), 3-O-trans-caffeoylbetulinic acid (8), dammarenediol II 3-caffeate (9), 12-oleanene-3β,6α-diol (10), 11α-hydroxy-3β-amyrin (11), nivadiol (12), 29-hydroxyfriedelin (13), and celastrusin
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Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study. J. Nat. Med. (IF 2.055) Pub Date : 2020-08-06 Jieru Han,Guangyu Shi,Wenhao Li,Ying Xie,Fuzhen Li,Deyou Jiang
Monosodium urate (MSU)-mediated inflammation is closely related to gouty arthritis (GA). Dioscin, an active ingredient, has been reported to possess anti-inflammatory property. Nevertheless, the role of dioscin in GA and the underlying mechanism have not been fully understood. In the present study, we investigated the anti-inflammatory effect of dioscin on MSU-induced GA through in vivo and in vitro
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Characterization of metabolites in Saposhnikovia divaricata root from Mongolia. J. Nat. Med. (IF 2.055) Pub Date : 2020-08-01 Zolboo Batsukh,Kazufumi Toume,Batkhuu Javzan,Kohei Kazuma,Shao-Qing Cai,Shigeki Hayashi,Toshiyuki Atsumi,Taichi Yoshitomi,Nahoko Uchiyama,Takuro Maruyama,Nobuo Kawahara,Katsuko Komatsu
Saposhnikoviae Radix (SR), derived from the dried root and rhizome of Saposhnikovia divaricata, is a popular crude drug used in traditional Chinese and Japanese medicine. To evaluate the metabolites of S. divaricata roots from Mongolia and to investigate their geographical variation, we developed the HPLC method, determined the contents of 9 chromones and 4 coumarins, and conducted multivariate statistical
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Quality evaluation of Angelicae acutilobae radix: individual differences and localization of (Z)-ligustilide in Angelica acutiloba root. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-31 Yoshitomi Kudo,Hirokazu Ando,Yohei Sasaki
It has been difficult to evaluate the quality of Angelicae acutilobae Radix (Toki) because of large differences in the contents of its chemical constituents. In this research, we revealed individual differences and localization of (Z)-ligustilide in Toki cultivated and processed under the same conditions. Thirteen Toki samples (dry weight: 68.2 g–132.3 g) were divided and categorized into 13 parts
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Two new sesquiterpenes from Artemisia annua L. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-24 Yukiko Takenaka,Satoko Seki,Toyoyuki Nishi,Takao Tanahashi
Investigation of the dried whole plants of Artemisia annua led to the isolation of two new sesquiterpenes, artemanins A (1) and B (2), along with twenty-nine known compounds. The structures of the new compounds were elucidated by spectroscopic and chemical means.
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Two new phenylpropanoids from the resin of Styrax tonkinensis (Pierre) Craib ex Hartw. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-21 Feng Wang,Li Zhang,Qing Zhang,Ali Chen,Shumei Wang,Zhenfeng Fang
AbstractTwo new phenylpropanoids, named stytonkinol A (1) and stytonkinol B (2), have been isolated from the resin of Styrax tonkinensis (Pierre) Craib ex Hartw. Their structures were determined by spectroscopic analysis, including 1D and 2D NMR, and HR-ESI–MS. Two isolated compounds were assayed for cytotoxic activities against five tumor cell lines (HepG-2, A549, Hela, MCF-7, and PC-3) by Cell Counting
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Sauchinone: a prospective therapeutic agent-mediated EIF4EBP1 down-regulation suppresses proliferation, invasion and migration of lung adenocarcinoma cells. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-15 Sheng-Qian Li,Jing Feng,Ming Yang,Xiao-Peng Ai,Mei He,Fu Liu
Lung adenocarcinoma (LUAD) is the top prevalent histological kind of lung cancer worldwide. Recent evidences have demonstrated that Sauchinone plays an anticancer role in tumor cell invasion and migration. Therefore, we performed this investigation to explain the potential role of Sauchinone in LUAD as well as the potential mechanism involved. Cell counting kit 8 (CCK-8) and transwell experiments were
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Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/β-catenin pathway. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-12 Cai Liu,Dongqiang He,Qiming Zhao
Traumatic brain injury (TBI) is a major cause of death and disability around the world with no effective treatments currently. The present study was aimed to investigate the neuroprotective effect of licoricidin, one of the major components of licorice extract, on TBI mice and further explore the underlying mechanism. Male C57BL/6 mice were modeled by a modified weight-drop method to mimic TBI. All
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Isolation and evaluation of cardenolides from Lansium domesticum as Notch inhibitors. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-09 Anna Tsuchiya,Yoshinori Makita,Takashi Koyano,Thaworn Kowithayakorn,Masami Ishibashi,Midori A Arai
AbstractSince Notch signaling plays important roles in cell proliferation and differentiation, aberrant activation of this signaling contributes to cancer progression. In neural stem cells, Notch signaling inhibits differentiation by activating HES1 expression. Therefore, Notch signaling inhibitors may be candidates for new anticancer drugs or have applications in neural regenerative medicine. In this
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Anti-inflammatory canthin-6-one alkaloids from the roots of Thailand Eurycoma longifolia Jack. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-08 Ying Zhang,Wei Zhao,Jingya Ruan,Nuttapong Wichai,Zheng Li,Lifeng Han,Yi Zhang,Tao Wang
AbstractTwo new canthin-6-one alkaloids, 4,9-dimethoxy-5-hydroxycanthin-6-one (1) and 9-methoxy-(R/S)-5-(1-hydroxyethyl)-canthin-6-one (2), together with fifteen known ones were isolated from the roots of Thailand Eurycoma longifolia Jack. Among the known canthin-6-one alkaloids, compounds 9 and 16 were isolated from the Eurycoma genus for the first time. Meanwhile, the nitric oxide (NO) inhibitory
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The search for, and chemistry and mechanism of, neurotrophic natural products. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-08 Yoshiyasu Fukuyama,Miwa Kubo,Kenichi Harada
AbstractNeurotrophic factors, now termed neurotrophins, which belong to a class of polypeptidyl agents, have been shown to potentially be beneficial for the treatment of neurodegenerative diseases such as Alzheimer’s disease, because endogenous neurotrophic factors (NGF, BDNF, NT3, NT4) have been recognized to play critical roles in the promotion of neurogenesis, differentiation, and neuroprotection
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Antiangiogenic effects of AG36, a triterpenoid saponin from Ardisia gigantifolia stapf. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-08 Li-Hua Mu,Li-Hua Wang,Yu-Ning Wang,Ping Liu,Can Yan
AG36 is a triterpenoid saponin from Ardisia gigantifolia stapf. Our recent studies proved that AG36 displayed prominent cytotoxicity against breast cancer cells both in vitro and in vivo. However, whether AG36 has antiangiogenic properties is unknown. Therefore, in the present study, we evaluated the antiangiogenic effect of AG36 and the underlying mechanism. The results indicated that AG36 could significantly
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Firmosides A and B: two new sucrose ferulates from the aerial parts of Silene firma and evaluation of radical scavenging activities. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-06 Nguyen Hoang Uyen,Retno Widyowati,Melanny Ika Sulistyowaty,Sachiko Sugimoto,Yoshi Yamano,Susumu Kawakami,Hideaki Otsuka,Katsuyoshi Matsunami
AbstractTwo new tri-ferulates of sucrose, firmosides A and B (1 and 2, respectively), together with 18 known compounds (3–20), were isolated from the aerial parts of Silene firma. The structures of the isolated compounds were elucidated by various spectroscopic methods, including 1D, 2D NMR, and high-resolution electro-spray ionization–mass spectrometry (HR-ESI–MS). All the isolated compounds were
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Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia. J. Nat. Med. (IF 2.055) Pub Date : 2020-07-03 Stipan Nurbek,Toshihiro Murata,Keisuke Suganuma,Yoshinobu Ishikawa,Buyanmandakh Buyankhishig,Takashi Kikuchi,Tseesuren Byambajav,Bekh-Ochir Davaapurev,Kenroh Sasaki,Javzan Batkhuu
AbstractArtemisia sieversiana is an annual herbaceous plant distributed throughout Central and East Eurasia and is regarded as an undesirable forage plant in Mongolia. It affects livestock, so information about its chemical composition is needed. We isolated three new sesquiterpenoids (1–3) and known compounds from A. sieversiana and investigated their activities. The absolute configuration of 1 was
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Magnolol inhibits myotube atrophy induced by cancer cachexia through myostatin signaling pathway in vitro. J. Nat. Med. (IF 2.055) Pub Date : 2020-06-29 Zhijuan Ge,Dong Liu,Yue Shang,Yi Li,Shu-Zhen Chen
Cancer cachexia is a complex and multifactorial syndrome that influences about 50–80% of cancer patients and may lead to 20% of cancer deaths and muscle atrophy is the key characteristic of the syndrome. Recent researches have shown that myostatin is a negative regulator in the growth and differentiation of skeletal muscle. Herein, C2C12 cancer cachexia model was established with C26 conditioned culture
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The acrid raphides in tuberous root of Pinellia ternata have lipophilic character and are specifically denatured by ginger extract. J. Nat. Med. (IF 2.055) Pub Date : 2020-06-26 Tsukasa Fueki,Koichiro Tanaka,Kunihiko Obara,Ryudo Kawahara,Takao Namiki,Toshiaki Makino
Unprocessed dried tuberous root of Pinellia ternata (Pinellia Tuber) has been used as a component of traditional Japanese Kampo medicine, while this crude drug is usually used after processing with Ginger in traditional Chinese medicine (TCM). It is known that the raphides contained in unprocessed Pinellia Tuber can induce severe acrid irritation of the oral and laryngopharynx mucosa when it is boiled
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Correction to: Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases. J. Nat. Med. (IF 2.055) Pub Date : 2020-06-22 Ikuro Abe
The article Biosynthesis of medicinally important plant metabolites by unusual.
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Appetite-enhancing effects of inhaling cinnamon, clove, and fennel essential oils containing phenylpropanoid analogues. J. Nat. Med. (IF 2.055) Pub Date : 2020-06-15 Kakuyou Ogawa,Momoko Honda,Aoi Tanigawa,Arisa Hatase,Ayaka Ito,Yuki Higa,Osamu Morinaga
Cinnamon, clove, and fennel are commonly used as spices and herbal medicines, and one of their medicinal uses is as aromatic stomachics. We investigated the effect on appetite in mice of inhaling volatile compounds contained in essential oils extracted from herbal medicines used as aromatic stomachics. The appetite-enhancing effects of cinnamon and fennel essential oils were similar to those of their
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Cytotoxic activities of sesquiterpenoids from the aerial parts of Petasites japonicus against cancer stem cells. J. Nat. Med. (IF 2.055) Pub Date : 2020-06-13 Takahiro Matsumoto,Daisuke Imahori,Youhei Saito,Wei Zhang,Tomoe Ohta,Tatsusada Yoshida,Yuji Nakayama,Eishi Ashihara,Tetsushi Watanabe
AbstractFrom the methanolic extract of the aerial parts of Petasites japonicus, six new eremophilane-type sesquiterpenoids, petasitesterpenes I–VI were isolated together with eight known compounds including S-japonin and eremophilenolide. The chemical structures of the isolated new compounds were elucidated based on chemical/physicochemical evidence. For petasitesterpenes I and II, the absolute configurations
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Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response. J. Nat. Med. (IF 2.055) Pub Date : 2020-06-12 Seong Chul Jin,Mi Hye Kim,Si Yeon Jo,La Yoon Choi,Haesu Lee,Woong Mo Yang
Soshiho-tang (SSHT) has traditionally been used to treat gastrointestinal disorders. In this experiment, we investigated the protective effect of SSHT on inflammatory liver injury in lipopolysaccharide (LPS)-sensitized mice. Male C57BL/6J mice aged 6 weeks were randomly placed in 6 groups (n = 5): normal mice (CTR), LPS-sensitized mice (LPS), LPS-sensitized mice treated with dexamethasone (DEX) and
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