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In Silico Prediction and Molecular Simulation of Antimicrobial Peptide Variants From Lactobacillus sp. Against Porphyromonas gingivalis and Fusobacterium nucleatum in Oral Squamous Cell Carcinoma Pept. Sci. (IF 2.4) Pub Date : 2024-03-08 Zarin Taj, Indranil Chattopadhyay
Porphyromonas gingivalis and Fusobacterium nucleatum are known to contribute to a variety of tumorigenic pathways linked to the progression of oral squamous cell carcinoma (OSCC). The growing global incidence of antibiotic resistance highlights the critical need to consider the use of antimicrobial peptides (AMPs) as a viable alternative to conventional antibiotics. The current study comprehensively
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Oligopeptides analysis in spiderhawk's venom (Pepsis decorata Perty, 1833, Hymenoptera: Pompilidae) Pept. Sci. (IF 2.4) Pub Date : 2024-02-11 Matheus Nolasco, Douglas O. C. Mariano, Daniel C. Pimenta, Humberto Fonseca de Freitas, Samuel Silva da Rocha Pita, Alexsandro Branco
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Review on therapeutic potential of peptides: Advancements in synthesis methods, linear and cyclic peptides, and strategies for overcoming challenges Pept. Sci. (IF 2.4) Pub Date : 2024-02-01 Naurin Lalani, Sunil Tivari, Vicky Jain, Yashwantsinh Jadeja
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Oral delivery of the amylin receptor agonist pramlintide Pept. Sci. (IF 2.4) Pub Date : 2024-01-31 Celimar Sinézia, Tháyna Sisnande, Luis Peña Icart, Luís Maurício T. R. Lima
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Network pharmacology combined with molecular docking simulations reveal the mechanism of action of Glycyrrhiza for treating pneumonia Pept. Sci. (IF 2.4) Pub Date : 2024-01-17 Dongxin Yang, Zhehong Li, Yongrui Peng, Xiaofeng Zhu, Jun Gong, Cuilian Chen
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Investigation of commercially available resins for the automated flow synthesis of difficult or long peptide sequences Pept. Sci. (IF 2.4) Pub Date : 2024-01-11 Michael A. Lee, Joseph S. Brown, Andrei Loas, Bradley L. Pentelute
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Molecular mechanism study and potential active ingredients prediction of Danhe granules in the treatment of hypercholesterolemia via TICE Pept. Sci. (IF 2.4) Pub Date : 2024-01-11 Cong Shibo, Yu Tong, Wang Sili, Gu Shuxiao, Qiao Yanfang, Liu Susu, Gao Pan, Meng Jingke, Chai Xinlou
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A strategy for producing isotopically labeled peptides with antimicrobial activity or with short in vivo lifetime in Escherichia coli Pept. Sci. (IF 2.4) Pub Date : 2024-01-11 Qiongqiong Ren, Zejun Fan, Rong Han, Meihui Sang, Changxing Ma, Xiaoli Zhao, Shenlin Wang
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In silico prediction of preventive activities of bioactive hazelnut peptides against COVID-19 and Monkeypox 2022 Pept. Sci. (IF 2.4) Pub Date : 2024-01-10 Zeynep Saliha Güneş, Bilal Çakır, İbrahim Gülseren
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Crystal structures reveal that the sterically hindered pivaloyl-cisProlyl amide bond is energetically frustrated Pept. Sci. (IF 2.4) Pub Date : 2024-01-08 Shreya Banerjee, Sunil K. Gupta, Sunit Pal, Erode N. Prabhakaran
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Development and validation of cyclic peptide probe for gastric cancer based on phage display technique Pept. Sci. (IF 2.4) Pub Date : 2024-01-03 Seul Ki Yun, Seung Mok Yang, Moon Hwa Kwak, Jae Myung Park
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Chitin-binding peptides from Capsicum annuum with antifungal activity and low toxicity to mammalian cells and Galleria mellonella larvae Pept. Sci. (IF 2.4) Pub Date : 2024-01-03 Gabriella Rodrigues Gonçalves, Marciele Souza Silva, Layrana Azevedo dos Santos, Larissa Maximiniano Resende, Gabriel Bonan Taveira, Thomas Zacarone Afonso Guimarães, Sarah Rodrigues Ferreira, Antonia Elenir Amancio Oliveira, Celso Shiniti Nagano, Renata Pinheiro Chaves, André de Oliveira Carvalho, Rosana Rodrigues, Olney Vieira da Motta, Valdirene Moreira Gomes
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Electrostatic origin of a stabilizing synergistic interaction among b-, c-, and f-residues in a trimeric coiled coil Pept. Sci. (IF 2.4) Pub Date : 2023-12-05 Nicholas A. Dalley, Kimberlee L. Stern, Richard R. Kitchen, Keegan B. Lloyd, Joshua L. Price
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A network pharmacology approach to explore the molecular mechanism of active peptide ingredients of Carapax Trionycis on liver fibrosis Pept. Sci. (IF 2.4) Pub Date : 2023-10-19 Zhibin Yan, Guangyu Zhao, Qihao Lin, Guiping Zhuang, Jiayi Zhu, Juan Jin
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Investigating the interaction of azobenzene moiety on the aromatic amino acid tryptophan Pept. Sci. (IF 2.4) Pub Date : 2023-10-13 Charnette Frederic, Gregory R. Wiedman
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Bioactive peptides against angiotensin-converting enzyme I: An in silico study Pept. Sci. (IF 2.4) Pub Date : 2023-09-23 Antistio Alvíz-Amador, Neyder Contreras-Puentes, Johana Márquez-Lázaro
Bioactive peptides are currently emerging as nonpharmacological alternatives for treating noncommunicable diseases, including hypertension. Pharmacological treatments for hypertension typically involve angiotensin I converting enzyme inhibitors such as Captopril and enalapril. This study aimed to evaluate the activity of bioactive peptides derived from food sources against this enzyme and show its
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Cover Image Pept. Sci. (IF 2.4) Pub Date : 2023-09-20
Peptide Science publishes peer-reviewed papers covering all aspects of peptide synthesis, materials, structure and bioactivity. The journal includes both experimental and theoretical studies and serves the interdisciplinary biochemical, biomaterials, biophysical and biomedical research communities.
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Generation and study of antibodies against two triangular trimers derived from Aβ Pept. Sci. (IF 2.4) Pub Date : 2023-09-18 Adam G. Kreutzer, Ryan J. Malonis, Chelsea Marie T. Parrocha, Karen Tong, Gretchen Guaglianone, Jennifer T. Nguyen, Michelle N. Diab, Jonathan R. Lai, James S. Nowick
Monoclonal antibodies (mAbs) that target the β-amyloid peptide (Aβ) are important Alzheimer's disease research tools and are now being used as Alzheimer's disease therapies. Conformation-specific mAbs that target oligomeric and fibrillar Aβ assemblies are of particular interest, as these assemblies are associated with Alzheimer's disease pathogenesis and progression. This article reports the generation
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A compositional view comparing modern biological condensates and primitive phase-separated compartments Pept. Sci. (IF 2.4) Pub Date : 2023-08-30 Selene M. C. Cannelli, Ritvik Gupta, Tan Nguyen, Arunava Poddar, Srishti Sharma, Prachiti V. Vithole, Tony Z. Jia
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An in vitro evaluation of the biocompatibility of proline-alanine-serine peptides compared with polyethylene glycol and polyglycerol Pept. Sci. (IF 2.4) Pub Date : 2023-08-11 Qianyu Zhang, Hongjing Chen, Huali Chen
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Theoretical study of CHYMO32 peptide obtained by in silico fragmentation of the escapin protein isolated from marine hare Aplysia californica: A prediction for antimicrobial activity Pept. Sci. (IF 2.4) Pub Date : 2023-08-01 Macley Silva Cardoso, Jane Marlei Boeira
The scenario involving the alarming growth of bacterial resistance has never been more worrying. Increasingly selective and sophisticated bacterial strains resistant to traditional antibiotics are a threat to the health system worldwide. Therefore, antimicrobial peptides (AMPs) represent a promising path in the fight against multidrug-resistant pathogens. Here, using an in silico methodology, employing
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Toward a broad-spectrum peptide-based inhibitor of small multidrug resistance efflux pumps Pept. Sci. (IF 2.4) Pub Date : 2023-07-23 Chloe J. Mitchell, Kha M. Nguyen, Charles M. Deber
As an alternative approach to conventional antibiotics, here we explore a novel, rational drug design to target a resistance mechanism in antibiotic-resistant bacteria—the small multidrug resistance (SMR) efflux pump. SMRs are a membrane protein that consist of four transmembrane (TM) helices, which homodimerize via TM4 in an anti-parallel fashion through a GG7 motif. To target this interaction, we
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Conformationally constrained cyclic grafted peptidomimetics targeting protein–protein interactions Pept. Sci. (IF 2.4) Pub Date : 2023-07-20 Achyut Dahal, Vivekanandan Subramanian, Prajesh Shrestha, Dong Liu, Ted Gauthier, Seetharama Jois
Sunflower trypsin inhibitor-1 (SFTI-1) structure is used for designing-grafted peptides as a possible therapeutic agent. The grafted peptide exhibits multiple conformations in solution due to the presence of proline in the structure of the peptide. To lock the grafted peptide into a major conformation in solution, a dibenzofuran moiety (DBF) was incorporated in the peptide backbone structure, replacing
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Cover Image Pept. Sci. (IF 2.4) Pub Date : 2023-07-18
The total chemical synthesis of proteins has played a significant role in both fundamental research and therapeutic application, primarily due to its full and flexible control on the protein composition, allowing generation of biologically inaccessible protein forms. Utilizing a o-aminoaniline linker and taking full advantages of solid phase ligation to minimize tedious purification steps, Hong et
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Bicyclic peptides: Paving the road for therapeutics of the future Pept. Sci. (IF 2.4) Pub Date : 2023-07-09 Sven Ullrich, Christoph Nitsche
Bicyclic peptides have emerged as one of the driving forces within the constrained peptide family. Due to their unique pharmaceutical attributes, peptide bicycles have garnered a reputation as promising therapeutics of the future. Combining advantages of small molecule therapeutics and biologics, the target binding qualities of this highly constrained class of molecules have been likened to those of
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An in-silico-based study identified peptide inhibitors that can block the egression of the monkeypox virus by inhibiting the p37 protein target Pept. Sci. (IF 2.4) Pub Date : 2023-07-04 Swati Singh, Varshita Srivastava, Priya Godara, Hemanth Naick Banavath, Harshita Tak, Arya Nayak, Deepika Kumari, Biswajit Naik, Dhaneswar Prusty
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Controlled aggregation properties of threonine modified by protecting groups to unusual self-assembled structures Pept. Sci. (IF 2.4) Pub Date : 2023-06-22 Nidhi Gour, Vivekshinh Kshtriya, Bharti Koshti, Monisha Patel, Danil W. Boukhvalov
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Development of convergent hybrid phase ligation for efficient and convenient total synthesis of proteins Pept. Sci. (IF 2.4) Pub Date : 2023-05-25 Ziyong Z. Hong, Ruixuan R. Yu, Xiaoyu Zhang, Allison M. Webb, Nathaniel L. Burge, Michael G. Poirier, Jennifer J. Ottesen
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Nanomole-scale photochemical thiol-ene chemistry for high-throughput late-stage diversification of peptide macrocycles Pept. Sci. (IF 2.4) Pub Date : 2023-04-26 Mark D. Nolan, Mischa Schüttel, Eoin M. Scanlan, Alexander L. Nielsen
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Erratum: Current peptide vaccine and immunotherapy approaches against Alzheimer's disease Pept. Sci. (IF 2.4) Pub Date : 2023-04-19
Parrocha, C. M. T., Nowick, J. S., Pept. Sci. 2023, 115(1), e24289. https://doi.org/10.1002/pep2.24289 In the published article cited above, there was an error at the start of paragraph five, section two, β-Amyloid peptide vaccines where ACI-24 is introduced: the company behind ACI-24 was mis-attributed. The first sentence of the paragraph originally read: ACI-24 (AC Immune, Roche and Genentech) is
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Membrane permeability and antimicrobial peptides: Much more than just making a hole Pept. Sci. (IF 2.4) Pub Date : 2023-03-31 Juan C. Espeche, Romina Varas, Patricia Maturana, Andrea C. Cutro, Paulo C. Maffía, Axel Hollmann
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Host defense peptides identified in human apolipoprotein B as natural food bio-preservatives: Evaluation of their biosafety and digestibility Pept. Sci. (IF 2.4) Pub Date : 2023-03-29 Eliana Dell'Olmo, Katia Pane, Martina Schibeci, Angela Cesaro, Maria De Luca, Shurooq Ismail, Rosa Gaglione, Angela Arciello
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Fine-tuning the antimicrobial activity of β-hairpin peptides with fluorinated amino acids Pept. Sci. (IF 2.4) Pub Date : 2023-03-08 Suvrat Chowdhary, Tim Pelzer, Mareike Saathoff, Elisa Quaas, Johanna Pendl, Marcus Fulde, Beate Koksch
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Guidelines for designing peptoid structures: Insights from the Peptoid Data Bank Pept. Sci. (IF 2.4) Pub Date : 2023-03-08 James R. B. Eastwood, Ethan I. Weisberg, Dana Katz, Ronald N. Zuckermann, Kent Kirshenbaum
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Thermally-controlled spherical peptide gel architectures prepared using the pH switch method Pept. Sci. (IF 2.4) Pub Date : 2023-02-22 Sawsan Almohammed, Mohammed Benali Kanoun, Souraya Goumri-Said, Mir Waqas Alam, Agata Fularz, Abdullah Alnaim, James H. Rice, Brian J. Rodriguez
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The manifold role of octapeptide repeats in prion protein assembly Pept. Sci. (IF 2.4) Pub Date : 2023-01-30 Amy H. Guadagno, Scott H. Medina
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Temperature-induced structural change of integrin αvβ3 receptor and its interaction with the RGD peptide ligand Pept. Sci. (IF 2.4) Pub Date : 2022-12-28 Anqi Wang, Kai Yue, Yiang Wei, Weishen Zhong, Genpei Zhang
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Effective cell penetration of negatively-charged proline-rich SAP(E) peptides with cysteine mutation Pept. Sci. (IF 2.4) Pub Date : 2022-12-09 Sewon Lim, Jinhyuk Park, Seung-Eun Chong, Sungwhan Kim, Yoonhwa Choi, So Hee Nam, Yan Lee
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Chemical shifts of artificial monomers used to construct heterogeneous-backbone protein mimetics in random coil and folded states Pept. Sci. (IF 2.4) Pub Date : 2022-11-12 Shilpa R. Rao, Thomas W. Harmon, Shelby L. Heath, Jacob A. Wolfe, Jacqueline R. Santhouse, Gregory L. O'Brien, Alexis N. Distefano, Zachary E. Reinert, W. Seth Horne
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Targeting peptide-based quorum sensing systems for the treatment of gram-positive bacterial infections Pept. Sci. (IF 2.4) Pub Date : 2022-11-12 Tahmina A. Milly, Yftah Tal-Gan
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PL-101-WK, a novel tryptophan- and lysine-rich peptide with antimicrobial activity against Staphylococcus aureus Pept. Sci. (IF 2.4) Pub Date : 2022-10-05 Parvin Zadeh Shahraki, Parisa Farrokh
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Synoeca-MP: New insights into its mechanism of action by using NMR and molecular dynamics simulations approach Pept. Sci. (IF 2.4) Pub Date : 2022-07-30 Eliane Santana Fernandes Alves, Bruno de Paula Oliveira de Santos, Leticia Valvassori Rodrigues, Carlos Daniel Pereira Freitas, Lucianna Helene Silva dos Santos, Simoni Campos Dias, Octávio Luiz Franco, Luciano Morais Lião, Mariana Torquato Quezado de Magalhães
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Advances in the use of plants as potential biofactories in the production of antimicrobial peptides Pept. Sci. (IF 2.4) Pub Date : 2022-07-06 Cristiane dos Santos, Octávio Luiz Franco
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Current peptide vaccine and immunotherapy approaches against Alzheimer's disease Pept. Sci. (IF 2.4) Pub Date : 2022-06-24 Chelsea Marie T. Parrocha, James S. Nowick
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Peptide-assisted supramolecular polymerization of the anionic porphyrin meso-tetra(4-sulfonatophenyl)porphine Pept. Sci. (IF 2.4) Pub Date : 2022-06-14 Eric M. Kohn, David J. Shirley, Nicole M. Hinds, H. Christopher Fry, Gregory A. Caputo
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Facile synthetic method for peptoids bearing multiple azoles on side chains Pept. Sci. (IF 2.4) Pub Date : 2022-06-14 Yen Jea Lee, Soyeon Park, Yujeong Kim, Sun Hee Kim, Jiwon Seo
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Parallel arrangement of peptides appended to a rigid, bimetallic, constrained ring system Pept. Sci. (IF 2.4) Pub Date : 2022-06-04 Timothy P. Curran, Alessandro Marrone, Lauren M. Davidson, Niranjana Pokharel, Josephine F. Frempong, Iogann Tolbatov, Michael L. Phillip, Cosmic B. Gober, Haoyu Yang, Joanne Stewart
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Synthesis and biological evaluation of cilengitide derivatives on TGF-β1-induced epithelial-to-mesenchymal transition in human non-small cell lung cancer cells Pept. Sci. (IF 2.4) Pub Date : 2022-05-28 Kyeong-Yong Park, Jisu Jeong, Jiyeon Kim
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Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides Pept. Sci. (IF 2.4) Pub Date : 2022-05-27 Tien T. Dang, Peta J. Harvey, Lai Yue Chan, Yen-Hua Huang, Quentin Kaas, David J. Craik
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Linearized teixobactin is inactive and after sequence enhancement, kills methicillin-resistant Staphylococcus aureus via a different mechanism Pept. Sci. (IF 2.4) Pub Date : 2022-04-25 Qianhui Wu, Biswajit Mishra, Guangshun Wang
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Computational design of stapled peptide inhibitor against SARS-CoV-2 receptor binding domain Pept. Sci. (IF 2.4) Pub Date : 2022-04-19 Asha Rani Choudhury, Atanu Maity, Sayantani Chakraborty, Rajarshi Chakrabarti